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Kinoshita Kazuo  木下 和生

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KINOSHITA Kazuo  木下 和生

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Researcher Number 50293874
Other IDs
External Links
Affiliation (Current) 2025: 静岡社会健康医学大学院大学, 社会健康医学研究科, 教授
Affiliation (based on the past Project Information) *help 2022 – 2024: 静岡社会健康医学大学院大学, 社会健康医学研究科, 教授
2016: 滋賀県立成人病センター(研究所), 遺伝子研究部門, 専門研究員
2015: 滋賀県立成人病センター(研究所), その他部局等, 専門研究員
2005 – 2014: 滋賀県立成人病センター(研究所), 遺伝子研究部門, 専門研究員
2009: Research Institute, Shiga Medical Center, 遺伝子研究部門, 專門研究員 … More
2009: Research Institute, Shiga Medical Center, 遺伝子研究部門, 専門研究員
2008: 滋賀成人病センター研究所, 遺伝子研究部門, 研究員
2007: 滋賀県立成人病センター研究所, 遺伝子研究部門, 研究員
2005: Kyoto University, Graduate School of Medicine, Research Associate Professor, 医学研究科, 科学技術振興助教授
2005: 京都大学, 医科学研究科, 科学技術振興助教授
2003 – 2004: 京都大学, 医学研究科, 研究員(科学技術振興)
2003: 京都大学, 医学研究科・研究員(常勤形態 科学技術振興)
2003: 京都大学, 大学院・医学研究科, 助教授
2000 – 2002: Kyoto Univ., Grad.Sch.Med., Assistant Prof., 医学研究科, 助手
1999: 京都大学, 大学院・医学研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Experimental pathology / Medium-sized Section 58:Society medicine, nursing, and related fields / Pathological medical chemistry / Evolutionary biology / General medical chemistry / Immunology
Except Principal Investigator
Basic Section 58020:Hygiene and public health-related: including laboratory approach / Basic Section 55010:General surgery and pediatric surgery-related / Biological Sciences / Immunology / Thoracic surgery
Keywords
Principal Investigator
AID / 体細胞突然変異 / 突然変異 / クラススイッチ / 抗体 / DNA組換え / 免疫学 / RNA編集 / 人工基質 / Creリコンビナーゼ … More / クラススイッチ組換え / ゲノム / mutation / 癌 / 遺伝子 / エストロゲン受容体融合タンパク / 逆転写酵素阻害剤 / APOBEC / コホート / レトロウイルス / 脱核 / 赤血球 / genome / cancer / gene / Cre recombinase / class-switch recombination / somatic hypermutation / がん / 染色体テリトリー / 遺伝子間距離 / 染色体異常 / 染色体転座 / 分子腫瘍学 / 皮膚がん / 肝臓がん / 慢性炎症 / 感染 / 発がん / 精子 / 蛍光タンパク / 進化 / IgA / リンパ組織 / 環状DNA / 粘膜固有層 / 免疫グロブリン / スプライシング / 転写 / 組換え酵素 / Bリンパ球 / S領域 … More
Except Principal Investigator
Stat / 食品医学 / 地域住民コホート / シアル酸修飾 / 異種自己抗原 / 慢性炎症 / リン脂質 / 小児 / LoVo / SW620 / TTC7B / TTC7A / 腸閉鎖 / 炎症性腸疾患 / Transgenic Technology / Transcription Factor / Immune Memory Cell / Immunology / Transcription / Infectious Disease / CO Gene / Allergy / ゲノム / 癌 / メモリーB細胞 / メモリーT細胞 / 遺伝子欠損マウス / クラススイッチ / ADAR1 / 体細胞突然変異 / Follicular helper T cell / IL-21 / 胚中心B細胞 / Blimp-1 / c-Fos / STAT3 / AP-1 / BCL6 / 胚工学 / 転写因子 / 免疫記憶細胞 / 免疫学 / 発現制御 / 感染症 / 遺伝子 / アレルギー・喘息 / retrovirus / transcriptional coactivator / histone acetylation / DNA recombination / signal transduction / γδT cell / cytokine receptor / レトロウィルス / STAT / レトロウイルス / 転写共役因子 / ヒストンアセチル化 / DNA組換え / シグナル伝達 / γδT細胞 / サイトカインレセプター / AID / 上皮成長因子受容体 / 肺腺がん / 肺癌 / 呼吸器外科学 Less
  • Research Projects

    (19 results)
  • Research Products

    (51 results)
  • Co-Researchers

    (20 People)
  •  シアル化糖鎖抗原は動脈硬化・認知症の原因か? ~地域コホート研究を用いた検討~

    • Principal Investigator
      瀬藤 和也
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58020:Hygiene and public health-related: including laboratory approach
    • Research Institution
      Shizuoka Graduate University of Public Health
  •  内在性レトロウイルスが老化の指標および治療標的として役立つ可能性に関する研究Principal Investigator

    • Principal Investigator
      木下 和生
    • Project Period (FY)
      2024 – 2029
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 58:Society medicine, nursing, and related fields
    • Research Institution
      Shizuoka Graduate University of Public Health
  •  TTC7A欠損に起因する難治性腸閉鎖症のパラログ遺伝子発現促進による治療

    • Principal Investigator
      金井 理紗
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Japanese Red Cross Wakayama Medical Center
  •  Elucidation of erythroid differentiation using fsn micePrincipal Investigator

    • Principal Investigator
      Kinoshita Kazuo
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Research Institute, Shiga Medical Center
  •  Carcinogenesis by a mutagenic enzyme AIDPrincipal Investigator

    • Principal Investigator
      KAZUO Kinoshita
    • Project Period (FY)
      2011 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Research Institute, Shiga Medical Center
  •  Mechanisms of diseases by chromosomal translocationPrincipal Investigator

    • Principal Investigator
      KINOSHITA Kazuo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Research Institute, Shiga Medical Center
  •  Is activation-induced cytidine deaminase related to oncogenesis of lung cancer with induction of gene mutations observed in lung cancer?

    • Principal Investigator
      SONOBE Makoto
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Kyoto University
  •  Interaction between endogeneous mutator AID and exogenous oncogenic factors in carcinogenesisPrincipal Investigator

    • Principal Investigator
      KINOSHITA Kazuo
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Research Institute, Shiga Medical Center
  •  Carcinogenesis by a genome mutator AIDPrincipal Investigator

    • Principal Investigator
      KINOSHITA Kazuo
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Research Institute, Shiga Medical Center
  •  発がんにおける内在的突然変異誘導因子と外的因子の相互作用解析モデルの構築Principal Investigator

    • Principal Investigator
      木下 和生
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Interaction between endogenous mutator AID and exogenous oncogenic factors in carcinogenesisPrincipal Investigator

    • Principal Investigator
      KINOSHITA Kazuo
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Kyoto University
  •  精子形成における突然変異誘導機構の探索Principal Investigator

    • Principal Investigator
      木下 和生
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Evolutionary biology
    • Research Institution
      Kyoto University
  •  Study for Development and Maintenance of mune Memory

    • Principal Investigator
      TOKUHISA Takeshi
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
  •  RNA編集による抗体遺伝子のDNA情報変換機構Principal Investigator

    • Principal Investigator
      木下 和生
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  RNA編集による抗体遺伝子のDNA情報変換機構Principal Investigator

    • Principal Investigator
      木下 和生
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Kyoto University
  •  免疫グロブリン遺伝子における遺伝情報変換機構の解析Principal Investigator

    • Principal Investigator
      木下 和生
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  腸管粘膜におけるIgA抗体産生機構の解析Principal Investigator

    • Principal Investigator
      木下 和生
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  免疫グロブリンクラススイッチの分子機構解析Principal Investigator

    • Principal Investigator
      木下 和生
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Immunology
    • Research Institution
      Kyoto University
  •  Induction mechanism of V-J recombination by signaling molecules of the IL-7 receptor

    • Principal Investigator
      IKUTA Koichi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Immunology
    • Research Institution
      KYOTO UNIVERSITY

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Patent

  • [Journal Article] TGF-beta Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex2015

    • Author(s)
      Liang, G., Liu, G., Kitamura, K., Wang, Z., Chowdhury, S., Monjurul, A. M., Wakae, K., Koura, M., Shimadu, M., Kinoshita, K., and Muramatsu, M.
    • Journal Title

      PLoS Pathog.

      Volume: 11 Issue: 4 Pages: e1004780-e1004780

    • DOI

      10.1371/journal.ppat.1004780

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23390097, KAKENHI-PROJECT-26460993, KAKENHI-PROJECT-26861318
  • [Journal Article] Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer2015

    • Author(s)
      Kitamura, J., Uemura, M., Kurozumi, M., Sonobe, M., Manabe, T., Hiai, H., Date, H., and Kinoshita, K.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 2 Pages: e0117986-e0117986

    • DOI

      10.1371/journal.pone.0117986

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23390097
  • [Journal Article] Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models2014

    • Author(s)
      Nguyen, T., Xu, J., Chikuma, S., Hiai, H., Kinoshita, K., Moriya, K., Koike, K., Marcuzzi, G. P., Pfister, H., Honjo, T., Kobayashi, M.
    • Journal Title

      Int Immunol

      Volume: in press Pages: 1-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390097
  • [Journal Article] 核酸編集酵素 AID の発癌への関与2013

    • Author(s)
      喜夛村次郎、木下和生、伊達洋至
    • Journal Title

      日本臨床

      Volume: 71, Suppl 6 Pages: 118-121

    • Data Source
      KAKENHI-PROJECT-23390097
  • [Journal Article] Targeting activation-inducedcytidine deaminase prevents coloncancer development despite persistentcolonic inflammation2012

    • Author(s)
      Takai A, Marusawa H, Minaki Y, WatanabeT, Nakase H, Kinoshita K, Tsujimoto G,Chiba T.
    • Journal Title

      Oncogene

      Volume: 31 Issue: 13 Pages: 1733-1742

    • DOI

      10.1038/onc.2011.352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21229009, KAKENHI-PROJECT-23390097, KAKENHI-PROJECT-23390196, KAKENHI-PROJECT-24229005
  • [Journal Article] Chromosomal manipulation by site-specific recombinases and fluorescent protein-based vectors.2010

    • Author(s)
      Uemura, M, Niwa, Y, Kakazu, N, Adachi, N, Kinoshita, K.
    • Journal Title

      PLoS ONE vol.5.

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590326
  • [Journal Article] Chromosomal manipulation by site-specific recombinases and fluorescent protein-based vectors.2010

    • Author(s)
      Uemura, M, Niwa, Y, Kakazu, N, Adachi, N, Kinoshita, K
    • Journal Title

      PLoS ONE 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590326
  • [Journal Article] A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.2009

    • Author(s)
      Takai, A, Toyoshima, T, Uemura, M, Kitawaki, Y, Marusawa, H, Hiai, H, Yamada, S, Okazaki, IM, Honjo, T, Chiba, T, Kinoshita, K.
    • Journal Title

      Oncogene 28

      Pages: 469-478

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] Carboxy-terminal domain of AID required for its mRNA complex formation in vivo.2009

    • Author(s)
      Nonaka, T, Doi, T, Toyoshima, T, Muramatsu, M, Honjo, T, Kinoshita, K.
    • Journal Title

      Proc Natl Acad Sci U S A 106

      Pages: 2747-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers.2008

    • Author(s)
      Endo, Y, Marusawa, H, Kou, T, Nakase, H, Fujii, S, Fujimori, T, Kinoshita, K, Honjo, T, Chiba, T.
    • Journal Title

      Gastroenterology 135

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma.2008

    • Author(s)
      Komori, J, Marusawa, H, Machimoto, T, Endo, Y, Kinoshita, K, Kou, T, Haga, H, Ikai, I, Uemoto, S, Chiba, T.
    • Journal Title

      Hepatology 47

      Pages: 888-896

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] High expression of activation induced cytidine deaminase in human bile duct epithelium during cholangiocarcinogenesis.2007

    • Author(s)
      Komori, J, Marusawa, H, Machimoto, T, Endo, Y, Kinoshita, K, Kou, T, Haga, H, Ikai, I, Uemoto, S, Honjo, T, Chiba, T.
    • Journal Title

      Gastroenterology 132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] Ectopic expression of activation- induced cytidine deaminase in ulcerative colitis-associated colorectal cancers.2007

    • Author(s)
      Kou, T, Marusawa, H, Endo, Y, Nakase, H, Fujii, S, Kinoshita, K, Fujimori, T, Honjo, T, Chiba, T.
    • Journal Title

      Gastroenterology 132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signaling.2007

    • Author(s)
      Endo, Y, Marusawa, H, Kinoshita, K, Morisawa, T, Sakurai, T, Okazaki, IM, Watashi, K, Shimotohno, K, Honjo, T, Chiba, T.
    • Journal Title

      Oncogene 26

      Pages: 5587-95

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] Helicobacter pylori infection triggers aberrant expression of activation- induced cytidine deaminase in gastric epithelium.2007

    • Author(s)
      Matsumoto, Y, Marusawa, H, Kinoshita, K, Endo, Y, Kou, T, Morisawa, T, Azuma, T, Okazaki, IM, Honjo, T, Chiba, T.
    • Journal Title

      Nat Med 13

      Pages: 470-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.2007

    • Author(s)
      Kotani, A, Kakazu, N, Tsuruyama, T, Okazaki, IM, Muramatsu, M, Kinoshita, K, Nagaoka, H, Yabe, D, Honjo, T.
    • Journal Title

      Proc Natl Acad Sci U S A 104

      Pages: 1616-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis.2006

    • Author(s)
      Kou, T, Marusawa, H, Kinoshita, K, Endo, Y, Okazaki, IM, Ueda, Y, Kodama, Y, Haga, H, Ikai, I, Chiba, T.
    • Journal Title

      Int J Cancer 120

      Pages: 469-76

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] The dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond.2006

    • Author(s)
      Kinoshita, K, Nonaka, T.
    • Journal Title

      Int J Hematol 83

      Pages: 201-7

    • NAID

      10017421763

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] The Dark Side of Activation-Induced Cytidine Deaminase : Relationship with Leukemia and Beyond2006

    • Author(s)
      Kinoshita, K. et al.
    • Journal Title

      Int.J.Hematol. 83・3

      Pages: 201-207

    • NAID

      10017421763

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390115
  • [Journal Article] The dark side of activation-induced cytidine deaminase : relationship with leukemia and beyond2006

    • Author(s)
      Kinoshita, K. et al.
    • Journal Title

      Int.J.Hematol 83・3

      Pages: 201-207

    • NAID

      10017421763

    • Data Source
      KAKENHI-PROJECT-18390122
  • [Journal Article] The dark side of activation-induced cytidine deaminase : relationship with leukemia and beyond2006

    • Author(s)
      Kinoshita, K. et al.
    • Journal Title

      Int. J. Hematol. 83・3

      Pages: 201-207

    • NAID

      10017421763

    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] Negative regulation of activation- induced cytidine deaminase in B cells.2006

    • Author(s)
      Muto, T, Okazaki, IM, Yamada, S, Tanaka, Y, Kinoshita, K, Muramatsu, M, Nagaoka, H, Honjo, T.
    • Journal Title

      Proc Natl Acad Sci U S A 103

      Pages: 2752-2757

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Journal Article] A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression2005

    • Author(s)
      Kotani, A., Okazaki, I.M., M., Muramatsu, M., Kinoshita, K., Begum, N.A., Nakajima, T., Saito, H., Honjo, T.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 102

      Pages: 4506-4511

    • Data Source
      KAKENHI-PROJECT-16390115
  • [Journal Article] A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression2005

    • Author(s)
      Kotani, A., Okazaki, I.M., Muramatsu, M., Kinoshita, K., Begum, N.A., Nakajima, T., Saito, H., Honjo, T.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 102

      Pages: 4506-4511

    • Data Source
      KAKENHI-PROJECT-16021226
  • [Journal Article] A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression2005

    • Author(s)
      Kotani, A., Okazaki, I.M., Muramatsu, M., Kinoshita, K., Begum, N.A., Nakajima, T., Saito, H., Honjo, T.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 102

      Pages: 4506-4511

    • Data Source
      KAKENHI-PROJECT-15657056
  • [Journal Article] De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination2004

    • Author(s)
      Begum, N.A., Kinoshita, K., Muramatsu, M., Nagaoka, H., Shinkura, R., Honjo, T.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 101

      Pages: 13003-13007

    • Data Source
      KAKENHI-PROJECT-15657056
  • [Journal Article] Separate domains of AID are required for somatic hypermutation and class-switch recombination2004

    • Author(s)
      Shinkura, R., Ito, S., Begum, N.A., Nagaoka, H., Muramatsu, M., Kinoshita, K., Sakakibara, Y., Hijikata, H., Honjo, T.
    • Journal Title

      Nat.Immunol. 5

      Pages: 707-712

    • Data Source
      KAKENHI-PROJECT-16390115
  • [Journal Article] Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch2004

    • Author(s)
      Begum, N.A., Kinoshita, K., Kakazu, N., Muramatsu, M., Nagaoka, H., Shinkura, R., Biniszkiewicz, D, Boyer, L.A., Iaenisch, R., Honjo, T.
    • Journal Title

      Science 305

      Pages: 1160-1163

    • Data Source
      KAKENHI-PROJECT-16021226
  • [Journal Article] De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination2004

    • Author(s)
      Begum, N.A., Kinoshita, K., Muramatsu, M., Nagaoka, H., Shinkura, R., Honjo, T.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 101

      Pages: 13003-13007

    • Data Source
      KAKENHI-PROJECT-16390115
  • [Journal Article] Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch2004

    • Author(s)
      Begum, N.A., Kinoshita, K., Kakazu, N., Muramatsu, M., Nagaoka, H., Shinkura, R., Biniszkiewicz, D., Boyer, L.A., Jaenisch, R., Honjo, T.
    • Journal Title

      Science 305

      Pages: 1160-1163

    • Data Source
      KAKENHI-PROJECT-15657056
  • [Journal Article] Separate domains of AID are required for somatic hypermutation and class-switch recombination2004

    • Author(s)
      Shinkura, R., Ito, S., Begum, N.A., Nagaoka, H., Muramatsu, M., Kinoshita, K., Sakakibara, Y., Hijikata, H., Honjo, T.
    • Journal Title

      Nat.Immunol. 5

      Pages: 707-712

    • Data Source
      KAKENHI-PROJECT-16021226
  • [Journal Article] De novo protein synthesis is required for activation-induced cytidine deanmiase-dependent DNA cleavage in immunoglobulin class switch recombination2004

    • Author(s)
      Begum, N.A., Kinoshita, K., Muramatsu, M., Nagaoka, H., Shinkura, R., Honjo, T.
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 101

      Pages: 13003-13007

    • Data Source
      KAKENHI-PROJECT-16021226
  • [Journal Article] Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch2004

    • Author(s)
      Begum, N.A., Kinoshita, K., Kakazu, N., Muramatsu, M., Nagaoka, H., Shinkura, R., Biniszkiewicz, D., Boyer, L.A., Jaenisch, R., Honjo, T.
    • Journal Title

      Science 305

      Pages: 1160-1163

    • Data Source
      KAKENHI-PROJECT-16390115
  • [Journal Article] Separate domains of AID are required for somatic hypermutation and class-switch recombination2004

    • Author(s)
      Shinkura, R., Ito, S., Begum, N.A., Nagaoka, H., Muramatsu, M., Kinoshita, K., Sakakibara, Y., Hijikata, H., Honjo, T.
    • Journal Title

      Nat.Immunol. 5

      Pages: 707-712

    • Data Source
      KAKENHI-PROJECT-15657056
  • [Patent] レーザーマイクロダイセクション法およびその利用、並びに、油性封入剤2011

    • Inventor(s)
      木下 和生
    • Industrial Property Rights Holder
      木下 和生
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2012-205572
    • Filing Date
      2011-04-01
    • Acquisition Date
      2014-02-07
    • Data Source
      KAKENHI-PROJECT-23390097
  • [Presentation] EXPRESSION OF P63 IN ALVEOLAR LESION OF TRANSGENIC MICE EXPRESSING A MUTAGENIC CYTIDINE DEAMINASE, AID2013

    • Author(s)
      iro Kitamura, Munehiro Uemura, Hiroshi Hiai and Kazuo Kinoshita
    • Organizer
      6th p63/p73 International Workshop
    • Place of Presentation
      木更津
    • Data Source
      KAKENHI-PROJECT-23390097
  • [Presentation] AID は紫外線非依存的に皮膚扁平上皮癌の発生を促進する2013

    • Author(s)
      野中太一郎, 植村宗弘, 日合弘, 木下和生
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23390097
  • [Presentation] 部位特異的組換え酵素と蛍光タンパクを用いた染色体手術法の開発2010

    • Author(s)
      植村宗弘, 丹羽陽子, 木下和生
    • Organizer
      第57回日本生化学会近畿支部例会
    • Place of Presentation
      奈良先端科学技術大学院大学
    • Year and Date
      2010-05-22
    • Data Source
      KAKENHI-PROJECT-20590326
  • [Presentation] Cre組換え酵素による染色体間組換え頻度測定により明らかとなったテロメア近傍遺伝子のアクセシビリティー2010

    • Author(s)
      植村宗弘, 丹羽陽子, 嘉数直樹、足立典隆、木下和生
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-20590326
  • [Presentation] Cre組換え酵素による染色体間組換え頻度測定により明らかとなったテロメア近傍遺伝子のアクセシビリティー2010

    • Author(s)
      植村宗弘, 丹羽陽子, 嘉数直樹、足立典隆、木下和生
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-20590326
  • [Presentation] A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.2009

    • Author(s)
      Takai A, Toyoshima T, Uemura M, Niwa Y, Marusawa H, Hiai H, Honjo T, Chiba T, Kinoshita K
    • Organizer
      21st IUBMB and 12th EAOBMB International Congress of Biochemistry and Molecular Biology.
    • Place of Presentation
      上海(中国)
    • Year and Date
      2009-08-06
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Presentation] A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.2009

    • Author(s)
      Takai A, Toyoshima T, Uemura M, Niwa Y, Marusawa H, Hiai H, Honjo T, Chiba T, Kinoshita K.
    • Organizer
      21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology.
    • Place of Presentation
      上海, 中国
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Presentation] Chromosomal manipulation by site-specific recombinases and fluorescent protein-based vectors.2009

    • Author(s)
      植村宗弘, 丹羽陽子, 嘉数直樹, 足立典隆, 木下和生.
    • Organizer
      21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      上海(中国)
    • Year and Date
      2009-08-09
    • Data Source
      KAKENHI-PROJECT-20590326
  • [Presentation] 部位特異的組換え酵素と蛍光タンパクを用いた染色体手術法の開発2009

    • Author(s)
      植村宗弘、丹羽陽子、嘉数直樹、足立典隆、木下和生
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-20590326
  • [Presentation] Cre-loxP 組換え系と蛍光タンパクを用いた遺伝子間3次元的距離の測定2008

    • Author(s)
      植村宗弘, 足立典隆, 木下和生
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-20590326
  • [Presentation] 内在性変異原AIDによる抗体とがん細胞の進化2008

    • Author(s)
      木下和生
    • Organizer
      第80回日本遺伝学会大会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Presentation] A new mouse model of hepatocarcinogenesis triggered by activation-induced cytidine deaminase expressed in hepatic stem cells.2008

    • Author(s)
      Takai A, Marusawa H, Tabuchi Y, Ohtsuru S, Endo Y, Chiba T, Kinoshita K.
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-04-12
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Presentation] 発癌過程における遺伝子異常生成へのActivation-induced cytidine deaminase (AID)の関与2008

    • Author(s)
      遠藤容子、丸澤宏之、木下和生、本庶佑、千葉勉
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合 同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Presentation] Activation- induced cytidine deaminase serves as a link between inflammation to colitis- associated colorectal cancers.2008

    • Author(s)
      Endo Y, Marusawa H, Kinoshita K, Kou T, Fujii S, Fujimori T, Chiba T.
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-17013042
  • [Presentation] Cre-loxP組換え系と蛍光タンパクを用いた遺伝子間3次元的距離の測定2008

    • Author(s)
      植村宗弘、足立典隆、木下和生
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-20590326
  • [Presentation] 突然変異誘導因子AIDによる発がん2005

    • Author(s)
      木下和生, 野中太一郎
    • Organizer
      第64回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-17013042
  • 1.  村松 正道 (20359813)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  SONOBE Makoto (00432378)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  UEMURA Munehiro (30568390)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 4.  瀬藤 和也 (60771350)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  MIYAHARA Ryo (20335285)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  NAGAI Shinjiro (50447984)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  IKUTA Koichi (90193177)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  TANIGUCHI Yoshihito (00324616)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KUROOKA Hisanori (00293879)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  TOKUHISA Takeshi (20134364)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  竹森 利忠 (60114295)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  坂本 明美 (90359597)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  金井 理紗 (50935947)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  南 彰 (80438192)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  池川 雅哉 (60381943)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  シドニア ファガラサン
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  WATANABE Tomohiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  丸澤 宏之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  木下 芳一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  千葉 勉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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