Yanase Mikio 柳瀬幹雄

… Alternative Names

YANASE Mikio 柳瀬幹雄

Less

Researcher Number	50334397
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療センター, 医長
Affiliation (based on the past Project Information) *help	2002 – 2006: The University of Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 2001: The UNIV. OF TOKYO, FACULTY OF MEDICINE, INSTRUCTOR, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator LIPID PHOSPHATE PHOSPHOHYDROLASE / AUTOTAXIN / HEPATIC STELLATE CELLS / LYSOPHOSHATIDIC ACID / Auto taxin / Lysophospholipase D / 肝細胞 / 低分子量G淡白質Rho / Lipid phosphate phosphohydrolase / Autotaxin / 肝星細胞 / Lysophosphatidic acid … More Except Principal Investigator … More HGF / NADPH oxidase / Ischemic preconditioning / Leucine / 虚血再灌流障害 / Rho / Edg-5(S1P_2) / Hepatocytes / TGFα / 肝細胞 / スフィンゴシン1リン酸 / リゾフォスファチジン酸 / Bioactivity / Translational research / Nutrition / Regenerative medicine / トランスレイショナルリサー / 生理活性 / トランスレイショナルリサーチ / 栄養学 / 再生医学 / Liver damage / Liver cirrhosis / Liver fibrosis / Lysophosphatidic acid / Autotaxin / 肝障害 / 肝硬変 / 肝線維化 / オートタキシン / Transplantation and regeneration / Oxidative stress / Oxygen radicals / Kupffer cells / reperfusion injury / Ischemia / reactive oxygen species(ROS) / 移植・再生医療 / 酸化ストレス / 活性酸素 / Kupffer細胞 / ロイシン / LIVER TRANSPLANTATION / ISCHEMIC PRECONDITIONING / REPERFUSION INJURY / ISCHEMIA / 虚血再潅流障害 / 肝移植 / ischemic preconditioning / liver regeneration / sphingosine 1-phosphate / EDG5 / 肝再生 / functions / proliferation / 機能 / 増殖 / LYSOPHOSPHATIDIC ACID / SPHINGOSINE 1-PHOSPHATE / HEPATIC STELLATE CELLS / PORTAL HYPERTENSION / スフィンゴシンコリン酸 / 星細胞 / 門脈圧亢進症 Less

Modulation by amino acids of the expression of factors produced by hepatic stellate cells : its implication in injured liver
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Research for mechanisms of induction of hepatic ischemic tolerance by ischemic preconditioning.
- Principal Investigator
  
  TEJIMA Kazuaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the clinical significance of autotaxin and lysophosphatidic acid in liver diseases.
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Induction of hepatocyte growth factor by physiological agents : its effects on hepatocyte proliferation and protein production
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Functional Analysis of The Biological Activities of a Lipid Mediator, Lysophoshatidie Acid, on The Pathogenesis of Liver FibrosisPrincipal Investigator
- Principal Investigator
  
  YANASE Mikio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Elucidation of the mechanism of the inhibitory effect of sphingosine 1-phosphate on hepatocyte proliferation and the significance in liver regeneration
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
LIVER PROTECTION AGAINST ISCHEMIAJREPERFUSION INJURY BY ISCHEMIC PRECONDITIONING
- Principal Investigator
  
  ARAI Masahiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO
Significance of growth factors for Hepatocyte proliferation and functions
- Principal Investigator
  
  TOMIYA Tomoaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
PORTAL HYPERTENSION-ELUCIDATION OF THE MECHANISM IN THE LIGHT OF FUNCTIONAL ABNORMALITIES OF HEPATIC STELLATE CELLS AND DEVELOPMENT OF THERAPEUTIC STRATEGY
- Principal Investigator
  
  IKEDA Hitoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  THE UNIVERSITY OF TOKYO

All 2007 2006 2005 2004 2003

All Journal Article Presentation

[Journal Article] Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.2007
- Author(s)
  Watanabe N, Ikeda H, Nakamura K, Obkawa R, Kume Y, Aoki J, Hama K, Okudaira S, Tanaka M, Tonriya T, Yanase M, Tejima K, Nishikawa T, Arai M, Arai H, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  J Clin Gastroenterol 41
  
  Pages: 616-623
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity2007
- Author(s)
  Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Tomiya T, Tejima K, Nishikawa T, Arai M, Yanase M, Aoki J, Arai H, Omata M, Fujiwara K, Yatomi Y.
- Journal Title
  
  Life Sci 81
  
  Pages: 1009-1015
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, Inoue Y, Nishikawa T, Watanabe N, Ohtomo N, Omata M, Fujiwara K.
- Journal Title
  
  World J Gastroenterol 13
  
  Pages: 5071-5078
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Ischemic preconditioning in liver pathophysiology2007
- Author(s)
  Arai M, Tejima K, Ikeda H, Tomiya T, Yanase M, Inoue Y, Nagashima K, Nishikawa T, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  J Gastroenterol Hepatol 22 : S1
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors.2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, Nagashima K, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  Chemotherapy 53
  
  Pages: 59-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells.2007
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, moue Y, Nishikawa T, Watanabe N, Ohtomo N, Omata M, fujiwara K.
- Journal Title
  
  World J Gastroenterol 13
  
  Pages: 5071-5078
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Plasma 1ysophosphatidic acid level and serum autotaxin activity are increased in in liver injury in rats in relation to its severity2007
- Author(s)
  Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Tomiya T, Tejima K, Nishikawa T, Arai M, Yanase M, Aoki J, Arai H, Omata M Fujiwara K, Yatomi Y.
- Journal Title
  
  Life Sci 81
  
  Pages: 1009-1015
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, Nagashima K, Watanabe N, Omata M, Fujiwara K.
- Journal Title
  
  Chemotherapy 53
  
  Pages: 59-69
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors.2007
- Author(s)
  Tomiya T, Yamaoka M, Inoue Y, Nishikawa T, Yanase M, Ikeda H, Tejima K, et al.
- Journal Title
  
  Chemotherapy 53・1
  
  Pages: 59-69
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells.2006
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, Inoue Y, Tejima K, et al.
- Journal Title
  
  Life Sciences 78・19
  
  Pages: 2226-2233
- Data Source
  KAKENHI-PROJECT-18590719
[Journal Article] Hepatocyte preconditioning via activation of NADPH oxidase in Kupffer cells against warm ischemia/reperfusion injury.2005
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Hepatology 42(4)
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Hepatocyte preconditioning via activation of NADPH oxidase in Kupffer cells against warm ischemia/reperfusion injury.2005
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M et al.
- Journal Title
  
  Hepatology 42(4)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590615
[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 320
  
  Pages: 754-759
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004
- Author(s)
  Tejima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Gastroenterology 127
  
  Pages: 1488-1496
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation.2004
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, Arai M, et al.
- Journal Title
  
  Biochem Biophys Res Commun 320
  
  Pages: 754-759
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] HMG-COA reductase inhibitor modulates collagen GEL-contraction by hepatic myofibroblast-like stellate cell line : involvement of geranylgeranylated proteins.2004
- Author(s)
  Yanase M, Ikeda H, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Comp Hepatol 3
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Treatment with leucine stimulates the production of hepatocyte growth factor in vivo.2004
- Author(s)
  Tomiya T, Inoue Y, Yanase M, Arai M, Ikeda H et al.
- Journal Title
  
  Biochem Biophys Res Commun. 322
  
  Pages: 772-777
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] HMG-COA reductase inhibitor modulates collagen GEL-contraction by hepatic myofibroblast-like stellate cell line : involvement of geranylgeranylated proteins.2004
- Author(s)
  Yanase M, Ikeda H, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Comp Hepatol. 3
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.2004
- Author(s)
  Tajima K, Arai M, Ikeda H, Tomiya T, Yanase M, et al.
- Journal Title
  
  Gastroenterology 127
  
  Pages: 1488-1496
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Antiproliferative Property of Sphingosine 1-Phosphate in Rat Hepatocytes Involves Activation of Rho Via Edg-5.2003
- Author(s)
  Ikeda H, Satoh H, Yanase M, Inoue Y, Tomiya T, et al.
- Journal Title
  
  Gastroenterology 124
  
  Pages: 459-469
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Functional Diversity between Rho-Kinase and MLCK-Mediated Cytoskeletal Actions in a Myofibroblast-Like Hepatic Stellate Cell Line.2003
- Author(s)
  Yanase M, Ikeda H, Ogata I, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Biochem Biophys Res Commun. 305
  
  Pages: 223-228
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells.2003
- Author(s)
  Skeda H, Nagashima K, Yanase M, Tomiya T, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 285
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Functional Diversity between Rho-Kinase-and MLCK-Mediated Cytoskeletal Actions in a Myofibroblast-Like Hepatic Stellate Cell Line.2003
- Author(s)
  Yanase M, Ikeda H, Ogata I, Matsui A, Noiri E, Tomiya T, et al.
- Journal Title
  
  Biochem Biophys Res Commun 305
  
  Pages: 223-228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Journal Article] Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells.2003
- Author(s)
  Ikeda H, Nagashima K, Yanase M, Tomiya T, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590625
[Presentation] Induction of P53-related effector genes may regulate hepatocyte proliferation stimulated by hepatocyte growth factor2006
- Author(s)
  Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Yanase M, Ikeda H, Tejima K, Omata M, Fujiwara K.
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Colorado, USA
- Year and Date
  2006-07-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590719
[Presentation] Induction of P53-related effector genes may regulate hepatocyte proliferation stimulated by hepatocyte growth factor2006
- Author(s)
  Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Yanase M, Ikeda H, Tejima K, Omata M, Fujiwara K.
- Organizer
  FASEB Summer Research Conference
- Place of Presentation
  Snowmass, Colorado, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590719

1. TOMITA Tomoaki (90227637)

# of Collaborated Projects: 9 results

# of Collaborated Products: 25 results
2. IKEDA Hitoshi (80202422)

# of Collaborated Projects: 9 results

# of Collaborated Products: 25 results
3. ARAI Masahiro (60271566)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
4. TEJIMA Kazuaki (30396733)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
5. YATOMI Yutaka (60200523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yanase Mikio 柳瀬 幹雄

YANASE Mikio 柳瀬 幹雄

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional Analysis of The Biological Activities of a Lipid Mediator, Lysophoshatidie Acid, on The Pathogenesis of Liver FibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Ischemic preconditioning in liver pathophysiology2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Effect of rapamycin on hepatocyte function and proliferation induced by growth factors.2007

Author(s)

Journal Title

Data Source

[Journal Article] Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells.2007

Author(s)

Journal Title

Description

Data Source

Yanase Mikio 柳瀬幹雄

YANASE Mikio 柳瀬幹雄