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YASUI Kiyoshi  安井 潔

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Yasui Kiyoshi  安井 潔

安井 潔  ヤスイ キヨシ

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Researcher Number 50372777
Other IDs
External Links
Affiliation (Current) 2025: 長崎大学, 医歯薬学総合研究科(医学系), 助教
Affiliation (based on the past Project Information) *help 2025: 長崎大学, 医歯薬学総合研究科(医学系), 助教
2019 – 2023: 長崎大学, 医歯薬学総合研究科(医学系), 助教
2015 – 2017: 長崎大学, 医歯薬学総合研究科(医学系), 助教
2005 – 2006: 長崎大学, 大学院医歯薬学総合研究科, 助手
2004 – 2005: Nagasaki University, Graduate School of Biomedical Sciences, Research Associate, 大学院・医歯薬学総合研究科, 助手
Review Section/Research Field
Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 55020:Digestive surgery-related
Except Principal Investigator
General medical chemistry / Basic Section 55020:Digestive surgery-related / Virology / Molecular biology / Biological Sciences
Keywords
Principal Investigator
免疫逃避 / デザイナー細胞 / 移植療法 / MHC / 移植医療 / T細胞 / NK細胞 / IRFファミリー / CD47 / ステルスT細胞 … More / HLA-E / MHC Class I / T細胞輸注療法 / がん免疫 … More
Except Principal Investigator
リン酸化 / ヒストン / クロマチン / 遺伝子転写 / ヌクレオソーム / transcription / chromatin / nucleosome / phosphorylation / acetylation / histone / 再構築 / 翻訳後修飾 / ユビキチン化 / エピジェネティクス / アセチル化 / 細胞輸注療法 / 細胞傷害性T細胞 / 腫瘍殺傷 / T細胞 / 腫瘍免疫 / ワクチン / キラーT細胞 / 抗原欠損バリアント / 養子免疫療法 / interferon / IFI6 / FAT10 / IDO1 / インターフェロン / HIV / expression control / genome / gene / 脱リン酸化 / 発現制御 / ゲノム / 遺伝子 / 転写開始 / クロストーク / 脱ユビキチン化 / 肝再生 / DNA高次構造 / DNA高次構浩 Less
  • Research Projects

    (9 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (11 People)
  •  フェロトーシス誘導を用いて腫瘍不均一性を克服する固形癌に有効なCAR-T療法の開発Principal Investigator

    • Principal Investigator
      安井 潔
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Nagasaki University
  •  免疫逃避機構を付与したデザイナー細胞を用いた新規移植療法の開発Principal Investigator

    • Principal Investigator
      安井 潔
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Nagasaki University
  •  Development of Novel Adoptive Cell Therapy for Tumors Containing antigen loss variants cells

    • Principal Investigator
      Muraoka Daisuke
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Aichi Cancer Center Research Institute
  •  Development of effective T cell therapy by stealth technique and regulation of IRF expressionPrincipal Investigator

    • Principal Investigator
      Yasui Kiyoshi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Nagasaki University
  •  Understanding the mechanism by which an interfeon-gamma-induced, mitochondria-localized novel protein inhibits virus infection

    • Principal Investigator
      KUBO Yoshinao
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Nagasaki University
  •  Post-translational histnoe modification and chromatin strucure

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  Phosphorylation and ubiquitylation of H2A regulate chromatin structure and function

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Nagasaki University
  •  Analysis of effect for DNA structure by phosphorylation of histone protein

    • Principal Investigator
      NAKAGAWA Takeya
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      Nagasaki University
  •  Core histone modifications change the higher order of DNA structurec resulting in its biological output

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Nagasaki University

All 2023 2022 2021 2020 2019 2016 2015 2004 2003

All Journal Article Presentation

  • [Journal Article] T cell receptor gene‐modified allogeneic T cells with siRNA for endogenous T cell receptor induce efficient tumor regression without graft‐versus‐host disease2023

    • Author(s)
      Satomi Okada, Daisuke Muraoka, Kiyoshi Yasui, Isao Tawara, Ayumi Kawamura, Sachiko Okamoto, Junichi Mineno, Naohiro Seo, Hiroshi Shiku, Susumu Eguchi, Hiroaki Ikeda
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 11 Pages: 4172-4183

    • DOI

      10.1111/cas.15954

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19532, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-19K23919, KAKENHI-PROJECT-21H02990
  • [Journal Article] Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors2022

    • Author(s)
      Dotsu Yosuke、Muraoka Daisuke、Ogo Naohisa、Sonoda Yudai、Yasui Kiyoshi、Yamaguchi Hiroyuki、Yagita Hideo、Mukae Hiroshi、Asai Akira、Ikeda Hiroaki
    • Journal Title

      Journal for ImmunoTherapy of Cancer

      Volume: 10 Issue: 2 Pages: e003958-e003958

    • DOI

      10.1136/jitc-2021-003958

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09048, KAKENHI-PROJECT-21H02609, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-21H02990
  • [Journal Article] IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement2022

    • Author(s)
      Kubo Yoshinao、Yasui Kiyoshi、Izumida Mai、Hayashi Hideki、Matsuyama Toshifumi
    • Journal Title

      Cells

      Volume: 11 Issue: 14 Pages: 2240-2240

    • DOI

      10.3390/cells11142240

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07593, KAKENHI-PROJECT-22K08581, KAKENHI-PROJECT-22K08876, KAKENHI-PROJECT-18K16773
  • [Journal Article] 固形がんを標的としたCAR-T細胞療法2021

    • Author(s)
      安井潔、池田裕明
    • Journal Title

      BIO Clinica

      Volume: 11 Pages: 26-30

    • Data Source
      KAKENHI-PROJECT-19K09048
  • [Journal Article] Nucleosome assembly protein 1 is a regulator of histone H1 acetylation2021

    • Author(s)
      Yoneda Mitsuhiro、Yasui Kiyoshi、Nakagawa Takeya、Hattori Naoko、Ito Takashi
    • Journal Title

      The Journal of Biochemistry

      Volume: 170 Issue: 6 Pages: 763-773

    • DOI

      10.1093/jb/mvab098

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K09048, KAKENHI-PROJECT-20K06489
  • [Journal Article] がん免疫における新規治療アプローチ 2)TCR-T細胞によるがん治療2020

    • Author(s)
      安井潔、池田裕明
    • Journal Title

      腫瘍内科

      Volume: 26 Pages: 71-78

    • Data Source
      KAKENHI-PROJECT-19K09048
  • [Journal Article] Fragments of target cells are internalized into retroviral envelope protein-expressing cells during cell-cell fusion by endocytosis.2016

    • Author(s)
      M. Izumida, H. Kamiyama, T. Suematsu, E. Honda, Y. Koizumi, K. Yasui, H. Hayashi, K. Ariyoshi, Y. Kubo
    • Journal Title

      Frontiers in Microbiology

      Volume: 6 Pages: 1552-1552

    • DOI

      10.3389/fmicb.2015.01552

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08499
  • [Journal Article] Gamma-interferon-inducible, lysosome/endosome-localized thiolreductase, GILT, has anti-retroviral activity and its expression is counteracted by HIV-12016

    • Author(s)
      Y. Kubo, M. Izumida, Y. Yashima, H. Yoshii-Kamiyama, Y. Tanaka, K. Yasui, H. Hayashi, T. Matsuyama
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 44 Pages: 71255-71273

    • DOI

      10.18632/oncotarget.12104

    • NAID

      120006847273

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08499
  • [Journal Article] Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.2004

    • Author(s)
      Aihara, H., Nakagawa, T., Yasui, K., Ohta, T., Hirose, S., Dhomae, N., Takio, K., Kaneko, M., Takeshima, Y., Muramatsu, M., Ito, T.
    • Journal Title

      Genes Dev 18

      Pages: 877-888

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390098
  • [Journal Article] Isfolavones stimulate estrogen receptor-mediated core histone acetylation2004

    • Author(s)
      Hong, T., Nakagawa, T., Pan, W., Kim, M.Y., Kraus, W.L., Ikehara, T., Yasui, K., Aihara, H., Takebe, M., Muramatsu, M., Ito, T.
    • Journal Title

      Biochem Biophys Res Commun 317

      Pages: 259-264

    • Data Source
      KAKENHI-PROJECT-15390098
  • [Journal Article] Isoflavones stimulate estrogen receptor-mediated core histone acetylation.2004

    • Author(s)
      Hong, T., Nakagawa, T., Pan, W., Kim, M.Y., Kraus, W.L, Ikehara, T., Yasui, K., Aihara, H., Takebe, M., Muramatsu, M., Ito, T.
    • Journal Title

      Biochem Biophys Res Commun 317

      Pages: 259-264

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390098
  • [Journal Article] Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo.2004

    • Author(s)
      Aihara, H., Nakagawa, T., Yasui, K., Ohta, T., Hirose, S., Dhomae, N., Takio, K., Kaneko, M., Takeshima, Y., Muramatsu, M., Ito, T
    • Journal Title

      Genes Dev 18

      Pages: 877-888

    • Data Source
      KAKENHI-PROJECT-15390098
  • [Journal Article] クロマチンの形成と再構築2003

    • Author(s)
      安井 潔, 伊藤 敬
    • Journal Title

      実験医学 21

      Pages: 1402-1407

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390098
  • [Journal Article] Chromatin assembly and remodeling2003

    • Author(s)
      Yasui, K., Ito, T.
    • Journal Title

      Jikkenigaku 21

      Pages: 1402-1407

    • NAID

      110000013990

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390098
  • [Presentation] 治療標的抗原発現が不均一な腫瘍に対する効果的な細胞輸注療法を担うT細胞の特徴解析と機構解明2023

    • Author(s)
      とう 思拓、村岡 大輔、中司 交明、安井 潔、原田 直純、澤田 晋一、秋吉 一成、池田 裕明
    • Organizer
      第82回日本癌学会学術総会 (横浜)
    • Data Source
      KAKENHI-PROJECT-21H03005
  • [Presentation] 腫瘍不均一性の克服へ向けた新規化合物のスクリーニング2023

    • Author(s)
      安井潔
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-22K08876
  • [Presentation] 腫瘍関連マクロファージ指向性CHPナノゲルの標的分子の探索2023

    • Author(s)
      中司 交明、村岡 大輔、安井 潔、原田 直純、澤田 晋一、秋吉 一成、永安 武、池田 裕明
    • Organizer
      第82回日本癌学会学術総会 (横浜)
    • Data Source
      KAKENHI-PROJECT-21H03005
  • [Presentation] 腫瘍不均一性の克服へ向けた新規化合物のスクリーニング2023

    • Author(s)
      安井潔
    • Organizer
      第27回日本がん免疫学会
    • Data Source
      KAKENHI-PROJECT-22K08876
  • [Presentation] Exploring the molecules involving in the drug delivery targeted to tumor-associated macrophages by CHP nanogels2022

    • Author(s)
      中司交明、村岡大輔、安井潔、原田直純、澤田晋一、秋吉一成、永安武、池田裕明
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21H03005
  • [Presentation] 腫瘍不均一性の克服に向けた"ステルス T 細胞"を用いたがん免疫療法の開発2022

    • Author(s)
      安井潔
    • Organizer
      第81回日本癌学会
    • Data Source
      KAKENHI-PROJECT-22K08876
  • [Presentation] フェロトーシス誘導剤を用いた腫瘍不均一性を克服するがん免疫療法の開発2021

    • Author(s)
      江原大輔、山口小百合、安井潔、村岡大輔、室田浩之、池田裕明
    • Organizer
      第25回日本がん免疫学会
    • Data Source
      KAKENHI-PROJECT-19K09048
  • [Presentation] 独自siRNAベクターによるMHC classⅠ発現抑制「ステルスT細胞」を用いたがん免疫療法の開発2021

    • Author(s)
      安井 潔、Xiangyue Meng、岡田怜美、岡本幸子、峰野純一、村岡大輔、 珠玖 洋、江口 晋、池田裕明
    • Organizer
      がん免疫学会
    • Data Source
      KAKENHI-PROJECT-19K09048
  • [Presentation] 独自siRNAベクターによるMHC class I発現抑制「ステルスT細胞」を用いたがん免疫療法の開発2021

    • Author(s)
      安井潔、MENG X、岡田怜美、岡本幸子、峰野純一、村岡大輔、珠玖洋、江口晋、池田裕明
    • Organizer
      第25回日本がん免疫学会
    • Data Source
      KAKENHI-PROJECT-19K09048
  • [Presentation] フェロトーシス現象を利用した腫瘍不均一性を克服するがん免疫療法2021

    • Author(s)
      江原大輔、山口小百合、安井潔、村岡大輔、室田浩之、池田裕明
    • Organizer
      第80回日本癌学会
    • Data Source
      KAKENHI-PROJECT-19K09048
  • [Presentation] T細胞やNK細胞による拒絶反応、およびGVHDを回避しうる「ステルスT細胞」を用いたがん免疫療法の開発2020

    • Author(s)
      安井 潔、岡田怜美、岡本幸子、峰野純一、村岡大輔、珠玖 洋、江口 晋、池田裕明
    • Organizer
      がん免疫学会
    • Data Source
      KAKENHI-PROJECT-19K09048
  • [Presentation] T細胞やNK細胞による拒絶反応、およびGVHDを回避しうる「ステルスT細胞」を用いたがん免疫療法の開発2020

    • Author(s)
      安井 潔、岡田怜美、岡本幸子、峰野純一、村岡大輔、珠玖 洋、江口 晋、池田裕明
    • Organizer
      がん免疫学会
    • Data Source
      KAKENHI-PROJECT-19K09048
  • [Presentation] 非自己T細胞の利用を可能にするステルスT細胞を用いたがん免疫療法の開発2019

    • Author(s)
      安井潔、岡田怜美、松村尚美、古賀洋一、岡本幸子、峰野純一、村岡大輔、珠玖 洋、江口 晋、池田裕明
    • Organizer
      がん免疫学会
    • Data Source
      KAKENHI-PROJECT-19K09048
  • [Presentation] Role of a samll GTP-binding protein, Rab3a, in the formation of HIV-1 virion2016

    • Author(s)
      Y.Kubo, M. Izumida, H. Masumoto, K. Yasui, H. Hayashi, T. Matsuyama
    • Organizer
      日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-15K08499
  • [Presentation] Placenta formation by human endogenous retrovirus is inhibited by interferons.2015

    • Author(s)
      M. Izumida, Y. Kubo, H. Hayashi, K. Yasui, T. Matsuyama
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県、福岡市)
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-15K08499
  • [Presentation] Identification of a CD63 binding protein and its role in HIV replication2015

    • Author(s)
      Y. Kubo, M. Izumida, H. Masumoto, K. Yasui, H. Hayashi, T. Matsuyama
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県、福岡市)
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-15K08499
  • 1.  NAKAGAWA Takeya (50363502)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 2.  ITO Takashi (90306275)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 3.  池田 裕明 (40374673)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 14 results
  • 4.  沖 昌也 (60420626)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  NANABA Yasuaki (90444869)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  MIZUSAKI Hirofumi (40467957)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  IKEHARA Tsuyoshi (90359951)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  KUBO Yoshinao (30273527)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 9.  Muraoka Daisuke (20608955)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 10.  浅井 章良 (60381737)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  金高 賢悟 (10549570)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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