YAMADA Shinichi 山田慎一

… Alternative Names

Researcher Number	50380853
Other IDs
External Links
Affiliation (Current)	2019: 信州大学, 学術研究院医学系(医学部附属病院), 准教授
Affiliation (based on the past Project Information) *help	2016 – 2018: 信州大学, 学術研究院医学系(医学部附属病院), 准教授 2016: 信州大学, 大学院医学系研究科, 准教授 2014: 長崎大学, 病院(歯学系), 講師 2011 – 2013: 長崎大学, 大学病院, 講師 2009 – 2011: Nagasaki University, 病院, 講師 2007 – 2008: Nagasaki University, Graduate School of Biomedical Sciences, Assistant Professor 2006: 長崎大学, 大学院医歯薬学総合研究科, 助手
Review Section/Research Field	Principal Investigator Surgical dentistry / Basic Section 57020:Oral pathobiological science-related Except Principal Investigator Morphological basic dentistry / Social dentistry / Functional basic dentistry
Keywords	Principal Investigator 口腔癌 / 浸潤 / 転移 / 分子シャペロン / actinin4 / EMS1 / siRNA / 浸潤能 / 増殖能 / RNAi … More Except Principal Investigator 癌幹細胞 / Hsp90 / SNP / 唾液腺腫瘍 / 組織構築 / 細胞外基質 / ニッチ / 免疫組織化学 / CD44, CD133 / 睡液腺腫瘍 / 多形腺腫 / 腺様嚢胞癌 / CD133 / CD44 / 腫瘍幹細胞 / 唾液腺 / 分子シャペロン / ダイマー / アイソフォーム / 2-ハイブリッドシステム / HSP90 / 熱ショックタンパク質 / ミスセンス変異 / Molecular chaperone / Dimer / Isoform / Two-hybrid system / 放射線性顎骨壊死 / 頭頸部がん / リスク因子 / 抜歯 / 根尖病巣 / 顎骨壊死 / 放射線治療 / 歯学 / 微小環境 / 扁平上皮癌 / リンパ節転移 / 癌関連マクロファージ / 癌関連好中球 / 癌関連線維芽細胞 / CCL2 / CCR2 / marginal histiocytosis / CAF / 口腔扁平上皮癌 / 転移 / 腫瘍関連好中球 / 腫瘍関連マクロファージ / CCL2-CCR2 pathway / CD204 / 放射線多発う蝕 / 多施設共同研究 / 他施設共同研究 Less

口腔癌頸部リンパ節転移被膜外浸潤進展度分類と進展メカニズムの分子細胞生物学的研究Principal InvestigatorOngoing
- Principal Investigator
  
  山田慎一
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Shinshu University
放射線性多発う蝕の発生機序の解明と予防法に関する多施設共同ランダム化比較試験Ongoing
- Principal Investigator
  
  五月女さき子
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Nagasaki University
A multicenter study of elucidation of status and risk factors of osteoradionecrosis of the jaw
- Principal Investigator
  
  兒島由佳
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Kansai Medical University
Involvement of microenvironment with cancer/epithelial stem cell in oral lesions
- Principal Investigator
  
  FUJITA Shuichi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Nagasaki University
The basic research of molecular taget therapy HSP90a and HIF-1a for oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  YAMADA Shin-ichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Nagasaki University
Cancer stem cells of salivary gland tumors : identification and contribution to histological morphogenesis
- Principal Investigator
  
  FUJITA Shuichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Nagasaki University
The basic research molecular target and immune therapy for oral squamous cell carcinoma with geldanamysin.Principal Investigator
- Principal Investigator
  
  YAMADA Shinichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Nagasaki University
Basic research of molecular therapy for oral squamous cell carcinomawith geldanamysinPrincipal Investigator
- Principal Investigator
  
  SHINICHI Yamada
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Nagasaki University
The study on molecular chaperones as a cancer therapy target
- Principal Investigator
  
  TAKAYUKI Nemoto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nagasaki University

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] FOXC2 expression is associated with tumor proliferation and invasion potential in oral tongue squamous cell carcinoma2015
- Author(s)
  Imayama N, Yamada S, et al.
- Journal Title
  
  Pathology and Oncology Research
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24792236
[Journal Article] Co-overexpression of cortactin and CRKII increases migration and invasive2014
- Author(s)
  Shin-ichi Yamada, et al.
- Journal Title
  
  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
  
  Volume: 26 Pages: 14-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792236
[Journal Article] 口腔扁平上皮癌の頸部リンパ節転移における被膜外浸潤の進展度分類の検討．2014
- Author(s)
  山田慎一, 他
- Journal Title
  
  頭頸部癌
  
  Volume: 40 Pages: 437-442
- NAID
  130004940793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24792236
[Journal Article] Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma2012
- Author(s)
  Yamada S
- Journal Title
  
  Cancer Letters
  
  Volume: 303 Pages: 84-91
- DOI
  10.1016/j.canlet.2011.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21792015
[Journal Article] Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma2011
- Author(s)
  Yamada S, Yanamoto S, Kawasaki G, Rokutanda S, Yonezawa H, Kawakita A, Nemoto TK
- Journal Title
  
  Cancer Lett
  
  Volume: 303(2) Pages: 84-91
- Data Source
  KAKENHI-PROJECT-21792015
[Journal Article] Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma2011
- Author(s)
  Shin-ichi Yamada, et al.
- Journal Title
  
  Cancer Letters
  
  Volume: (in press 掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21792015
[Journal Article] Overexpression of cortactin increases invasion potential in oral squamous cell carcinoma2010
- Author(s)
  Yamada S, Yanamoto S, Kawasaki G, Mizuno A, Nemoto TK
- Journal Title
  
  Pathol Oncol Res
  
  Volume: 16(4) Pages: 523-31
- Data Source
  KAKENHI-PROJECT-21792015
[Journal Article] RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma.2010
- Author(s)
  Yamada S.
- Journal Title
  
  Int J Oral Maxillofac Surg. 39
  
  Pages: 61-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21792015
[Journal Article] RNAi-mediated down-regulation of alpha-actinin-4 decreases invasion potential in oral squamous cell carcinoma2010
- Author(s)
  Yamada S, Yanamoto S, Yoshida H, Yoshitomi I, Kawasaki G, Mizuno A, Nemoto TK
- Journal Title
  
  Int J Oral Maxillofac Surg
  
  Volume: 39(1) Pages: 61-7
- Data Source
  KAKENHI-PROJECT-21792015
[Journal Article] Overexpression of Cortactin Increases Invasion Potential in Oral Squamous Cell Carcinoma.2010
- Author(s)
  Yamada S.
- Journal Title
  
  Pathol Oncol Res.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21792015
[Journal Article] Osteoblastoma in the maxilla : Report of a case.2009
- Author(s)
  Yamada S.
- Journal Title
  
  Oral Med Pathol 14
  
  Pages: 37-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21792015
[Journal Article] Synchronous double basal cell adenoma of the parotid gland : report of-a case2008
- Author(s)
  Yamada, S.
- Journal Title
  
  Oral Medicine & Pathology 13
  
  Pages: 21-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791508
[Journal Article] Substitution of only two residues of human Hsp90α causes impeded dimerization of Hsp90β2008
- Author(s)
  Kobayakawa T., Yamada S., Mizuno A.and Nemoto T.K.
- Journal Title
  
  Cell Stress and Chaperones (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592039
[Journal Article] Substitution of only two residues of human Hsp90α causes impeded dimerization of Hsp90β2008
- Author(s)
  Kobayakawa T, Yamada S, Mizuno A, Nemoto T.K.
- Journal Title
  
  Cell Stress and Chaperones 13(1)
  
  Pages: 97-104
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592039
[Journal Article] Substitution of only two residues of human Hsp90α causes impeded dimerization of Hsp90β2008
- Author(s)
  Kobayakawa, T, Yamada, S, Mizuno, A, Nemoto, TK
- Journal Title
  
  Cell Stress Chaper 13, (1)
  
  Pages: 97-104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592039
[Journal Article] Articular Eminectomy for Chronic Bilateral Dislocation of the Temporomandibular Joint in Patients with Cerebral Infarction.2007
- Author(s)
  Shin-ichi Yamada
- Journal Title
  
  Asian Journal of Oral and Maxillofacial Sur gery 19(1)
  
  Pages: 48-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791508
[Journal Article] Giant Cell Fibroma of the Buccal Mucosa:A Case Report.2007
- Author(s)
  Shin-ichi Yamada
- Journal Title
  
  日本口腔診断学会雑誌 20(2)
  
  Pages: 444-447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791508
[Journal Article] Intraductal Papilloma of the Buccal Mucosa: A case report.2007
- Author(s)
  Shin-ichi Yamada
- Journal Title
  
  Asian Journal of Oral and Maxillofacial Sur gery 19(2)
  
  Pages: 113-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791508
[Journal Article] High-grade Papillary Cystadenocarcinoma of the sublingual gland : A case report.2006
- Author(s)
  Shin-ichi Yamada
- Journal Title
  
  Journal of Oral and Maxillofacial Surgery. (in press)
- Data Source
  KAKENHI-PROJECT-18791508
[Journal Article] Intraductal Papilloma of the Buccal Mucosa : A case report.2006
- Author(s)
  Shin-ichi Yamada
- Journal Title
  
  Asian Journai of Oral and Maxilloiacial Surgery. (in press)
- Data Source
  KAKENHI-PROJECT-18791508
[Journal Article] 下顎歯肉腺様扁平上皮癌と食道扁平上皮癌の同時性重複癌の一例2006
- Author(s)
  山田慎一
- Journal Title
  
  日本口腔外科学会雑誌 (in press)
- NAID
  10018858419
- Data Source
  KAKENHI-PROJECT-18791508
[Journal Article] 顎矯正手術症例の臨床統計的検討2006
- Author(s)
  山田慎一
- Journal Title
  
  日本口腔診断学会雑誌 19(2)
  
  Pages: 213-219
- NAID
  10025564343
- Data Source
  KAKENHI-PROJECT-18791508
[Presentation] 口腔扁平上皮癌浸潤能におけるSkp2によるSp1を介してのMMP-2, MMP-9の発現制御2014
- Author(s)
  山田　慎一、他
- Organizer
  第32回日本口腔腫瘍学会総会・学術集会
- Place of Presentation
  札幌市札幌コンベンションセンター
- Data Source
  KAKENHI-PROJECT-24792236
[Presentation] Skp2 はSp1を介してMMP-2, MMP-9の発現を制御し口腔扁平上皮癌浸潤に関与する2013
- Author(s)
  山田慎一、他
- Organizer
  第31回日本口腔腫瘍学会総会・学術集会
- Place of Presentation
  秋葉原
- Data Source
  KAKENHI-PROJECT-24792236
[Presentation] 口腔扁平上皮癌浸潤能におけるcortactin/CRK IIの発現の意義2011
- Author(s)
  山田慎一
- Organizer
  第65回日本口腔科学会総会学術集会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2011-04-21
- Data Source
  KAKENHI-PROJECT-21792015
[Presentation] 口腔扁平上皮癌浸潤能におけるシグナル伝達アダプター因子CRKの発現の意義(ポスター)2010
- Author(s)
  山田慎一, 他
- Organizer
  第55回(社)日本口腔外科学会総会学術集会
- Data Source
  KAKENHI-PROJECT-21792015
[Presentation] 口腔扁平上皮癌浸潤能におけるシグナル伝達アダプター因子CRKの発現の意義について2010
- Author(s)
  山田慎一, 他
- Organizer
  第55回日本口腔外科学会総会・学術集会
- Place of Presentation
  千葉県、幕張メッセ
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-21792015
[Presentation] 口腔扁平上皮癌におけるEMS1/ cortactinの発現の意義(ポスター)2009
- Author(s)
  山田慎一, 他
- Organizer
  第54回(社)日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21792015
[Presentation] 口腔扁平上皮癌におけるEMS1/cortactinの発現の意義2009
- Author(s)
  山田慎一
- Organizer
  第54回(社)日本口腔外科学会総会・学術大会
- Place of Presentation
  札幌
- Year and Date
  2009-10-09
- Data Source
  KAKENHI-PROJECT-21792015
[Presentation] 口腔扁平上皮癌におけるEMS1の発現の意義2009
- Author(s)
  山田慎一, 他
- Organizer
  第63回日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-21792015
[Presentation] 口腔扁平上皮癌におけるactinin4の発現の意義2008
- Author(s)
  山田慎一,柳本惣市,川崎五郎,吉冨泉,水野明夫
- Organizer
  第62回日本口腔科学会学術集会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-18791508
[Presentation] Amino acid substitutions observed in human Hsp90 isoforms that impede the dimeric interaction2008
- Author(s)
  Nemota TK, Kobayakawa T, Ono T, Yamada S, Mizuno A, Baba TT, Ohara-Nemoto Y
- Organizer
  2nd World Conference of Stress/ 3rd Cell Stress Society International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  ハンガリー、ブダペスト
- Year and Date
  2008-08-23
- Data Source
  KAKENHI-PROJECT-18592039
[Presentation] Impeded dimer formation caused by the SNP Gln488His of human Hsp90α2007
- Author(s)
  Kobayakawa, T, Yamada, S, Ohara-Nemoto, Y, Mizuno, A, Nemoto, TK
- Organizer
  30th Japanese Society of Molecular Biology/ 81st Congress of Japanese Biochemical Society
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2007-12-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592039
[Presentation] エナメル上皮種の臨床統計的ならびに病理組織学的検討2007
- Author(s)
  山田慎一
- Organizer
  第61回NPO法人日本口腔科学会学術集会
- Place of Presentation
  神戸市
- Year and Date
  2007-03-19
- Data Source
  KAKENHI-PROJECT-18791508
[Presentation] ヒトhsp90αSNPGln488>His変異によるHsp90ダイマー形成能の低下2007
- Author(s)
  小早川健, 山田慎一, 根本優子, 水野明夫, 根本孝幸
- Organizer
  第30回日本分子生物学会年会, 第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18592039
[Presentation] ヒト hsp90α SNP GIn488>His変異によるHsp90ダイマー形成能の低下2007
- Author(s)
  小早川健, 山田慎一, 根本優子, 水野明夫, 根本孝幸
- Organizer
  第30回日本分子生物学会年会、第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-18592039
[Presentation] Aminoacid substitutions observed in human Hsp90 isoforms that impede the dimeric interaction2007
- Author(s)
  Nemoto, T. K., Kobayakawa, T., Ono, T., Yamada, S., Mizuno, A., Baba, T., Ohara-Nemoto, Y.
- Organizer
  2nd World Conference of Stress, including 3rd Cell Stress Society International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Budapest, Hungry
- Data Source
  KAKENHI-PROJECT-18791508
[Presentation] Amino acid substitutions observed in human Hsp90 isoforms that impede the dimeric interaction2007
- Author(s)
  Nemoto, TK, Kobayakawa, T, Ono, T, Yamada, S, Mizuno, A, Baba, TT, Ohara-Nemoto, Y
- Organizer
  2nd World Conference of Stress and 3rd Cell Stress Society International Congress on Cell Stress Responses in Biology and Medicine
- Place of Presentation
  Budapest, Hungary
- Year and Date
  2007-08-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592039
[Presentation] Amino acid substitutions observed in human Hsp90 isoforms that impede the dimeric interaction2007
- Author(s)
  Nemoto TK, Kobayakawa T, Ono T, Yamada S, Mizuno A, Baba TT, Ohara-Nemoto Y
- Organizer
  2nd World Conference of Stress/3rd Cell Stress Society International Congress on Stress Res onses in Biolo and Medicine
- Place of Presentation
  ハンガリー、ブダペスト
- Year and Date
  2007-08-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18592039
[Presentation] ヒトhsp90αSNP Glu488>His変異によるHsp90ダイマー形成能の低下2007
- Author(s)
  小早川健,山田慎一,根本優子,水野野明夫,根本孝幸
- Organizer
  第30回日本分子生物学会総会,第80回日本生化学会大会合同大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18791508
[Presentation] 口腔扁平上皮癌の頸部リンパ節転移における被膜外浸潤の進展度分類の検討．
- Author(s)
  山田慎一、他
- Organizer
  第38回日本頭頸部癌学会
- Place of Presentation
  東京ファッションタウンビル（東京都江東区）
- Year and Date
  2014-06-12 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24792236

1. IKEDA Tohru (00211029)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 梅田正博 (60301280)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 長谷川巧実 (50546497)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. FUJITA Shuichi (00181355)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SHIBATA Yasuaki (80253673)

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6. 兒島由佳 (70720655)

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7. 五月女さき子 (20325799)

# of Collaborated Projects: 2 results

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8. 上田順宏 (40571005)

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9. 桐田忠昭 (70201465)

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10. 渋谷恭之 (90335430)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. TAKAYUKI Nemoto (90164665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
12. BABA Tomomi (60189727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. KANATANI Naoko (10380982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KOBAYAKAWA Takeshi (10153587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
15. NEMOTO Yuko (10164667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
16. 中村聡明 (60420452)

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17. 藤澤琢郎 (20330201)

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18. 山口泰平 (80230358)

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19. 栗田浩 (10273103)

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20. 大倉正也 (10281130)

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21. 柳本惣市 (10315260)

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22. 太田嘉英 (60233152)

# of Collaborated Projects: 1 results

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YAMADA Shinichi 山田 慎一

YAMADA Shin-ichi 山田 慎一

SHINICHI Yamada 山田 慎一

Research Projects

Research Products

Co-Researchers

口腔癌頸部リンパ節転移被膜外浸潤進展度分類と進展メカニズムの分子細胞生物学的研究Principal InvestigatorOngoing

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放射線性多発う蝕の発生機序の解明と予防法に関する多施設共同ランダム化比較試験Ongoing

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A multicenter study of elucidation of status and risk factors of osteoradionecrosis of the jaw

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Involvement of microenvironment with cancer/epithelial stem cell in oral lesions

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The basic research of molecular taget therapy HSP90a and HIF-1a for oral squamous cell carcinomaPrincipal Investigator

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Cancer stem cells of salivary gland tumors : identification and contribution to histological morphogenesis

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The basic research molecular target and immune therapy for oral squamous cell carcinoma with geldanamysin.Principal Investigator

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Basic research of molecular therapy for oral squamous cell carcinomawith geldanamysinPrincipal Investigator

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The study on molecular chaperones as a cancer therapy target

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[Journal Article] FOXC2 expression is associated with tumor proliferation and invasion potential in oral tongue squamous cell carcinoma2015

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[Journal Article] Co-overexpression of cortactin and CRKII increases migration and invasive2014

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[Journal Article] 口腔扁平上皮癌の頸部リンパ節転移における被膜外浸潤の進展度分類の検討．2014

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NAID

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[Journal Article] Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma2012

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DOI

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[Journal Article] Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma2011

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YAMADA Shinichi 山田慎一

YAMADA Shin-ichi 山田慎一

SHINICHI Yamada 山田慎一