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HASEGAWA TAKUMI  長谷川 巧実

ORCIDConnect your ORCID iD *help
Researcher Number 50546497
Other IDs
Affiliation (Current) 2022: 神戸大学, 医学研究科, 講師
Affiliation (based on the past Project Information) *help 2022: 神戸大学, 医学(系)研究科(研究院), 講師
2019 – 2021: 神戸大学, 医学研究科, 講師
2018 – 2020: 神戸大学, 医学部附属病院, 助教
2016 – 2017: 神戸大学, 医学研究科, 助教
2014 – 2015: 神戸大学, 医学(系)研究科(研究院), 助教
2013: 神戸大学, 医学部附属病院, 助教
2012: 神戸大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Surgical dentistry / Basic Section 57060:Surgical dentistry-related
Except Principal Investigator
Basic Section 57060:Surgical dentistry-related / Social dentistry / Basic Section 57020:Oral pathobiological science-related / Basic Section 57080:Social dentistry-related
Keywords
Principal Investigator
炭酸ガス / 口腔癌 / 扁平上皮癌 / 転移 / 低酸素 / 低酸素環境 / 放射線抵抗性 / 副作用 / 治療抵抗性
Except Principal Investigator
抜歯 … More / 多施設共同研究 / 頸部リンパ節転移 / 被膜外浸潤 / 口腔癌 / 放射線性顎骨壊死 / 頭頸部がん / リスク因子 / 根尖病巣 / 顎骨壊死 / 放射線治療 / 歯学 / 放射線う蝕 / 放射線多発う蝕 / 他施設共同研究 / 口腔扁平上皮癌 / PD-LI / 頸部リンパ節 / PD-L1 / リンパ節転移 / 進展度分類 / 進展メカニズム / 唾液腺癌 / 融合遺伝子 / 発癌メカニズム / 新規分子標的治療 / 培養細胞 / オルガノイド / 分子標的薬 / 細胞培養 / 骨髄炎 / 血管新生 / 口腔感染症 / 骨抑制吸収薬 / 薬剤関連顎骨壊死 / 局所感染 / 休薬 / 口腔衛生状態 / 休薬期間 / 骨代謝 / 多施設共同前向き研究 / 扁平上皮癌 / 分子生物学的検討 / TRPイオンチャネル Less
  • Research Projects

    (12 results)
  • Research Products

    (9 results)
  • Co-Researchers

    (36 People)
  •  ミトコンドリアの正常化と癌関連線維芽細胞の再教育を目指した新規口腔癌治療法の開発Principal Investigator

    • Principal Investigator
      長谷川 巧実
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kobe University
  •  Molecular biological analysis of extracapsular spread of cervical lymph node metastasis in oral squamous cell carcinoma/

    • Principal Investigator
      山田 慎一
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Shinshu University
  •  環境因子による細胞内シグナル増強と腫瘍悪性化についての相関の解明

    • Principal Investigator
      榊原 晶子
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kobe University
  •  Analysis of fusion gene of salivary gland carcinogenesis and explore the molecular target agents

    • Principal Investigator
      野口 一馬
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Hyogo College of Medicine
  •  血管・リンパ管新生に着眼した歯性感染症-顎骨骨髄炎移行メカニズム解明と治療法探索

    • Principal Investigator
      明石 昌也
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kobe University
  •  A multicenter prospective study for elucidating the risk factors and establishing prevention methods of medical-related osteonecrosis of the jaws (MRONJ) .

    • Principal Investigator
      兒島 由佳
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57080:Social dentistry-related
    • Research Institution
      Kansai Medical University
  •  Molecular biological analysis of extracapsular spread of cervical lymph node metastasis in oral squamous cell carcinoma/

    • Principal Investigator
      Yamada Shin-ichi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57020:Oral pathobiological science-related
    • Research Institution
      Shinshu University
  •  治療抵抗性の改善と副作用の軽減を目指した革新的ながん治療法の開発応用Principal Investigator

    • Principal Investigator
      長谷川 巧実
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kobe University
  •  Prevention and mechanism of radiation-ralated dental caries: Muiticenter randomized contoroled trial

    • Principal Investigator
      SOUTOME Sakiko
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Social dentistry
    • Research Institution
      Nagasaki University
  •  A multicenter study of elucidation of status and risk factors of osteoradionecrosis of the jaw

    • Principal Investigator
      KOJIMA Yuka
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Social dentistry
    • Research Institution
      Kansai Medical University
  •  Transcutaneous carbon dioxide induces suppresses metastasis of oral squamous cell carcinomaPrincipal Investigator

    • Principal Investigator
      HASEGAWA TAKUMI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kobe University
  •  Development of the new treatment in oral cancer related to mitochondrial apoptosisPrincipal Investigator

    • Principal Investigator
      HASEGAWA TAKUMI
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kobe University

All 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] Relationship between dental status and development of osteoradionecrosis of the jaw: a multicenter retrospective study.2017

    • Author(s)
      Kojima Y, Yanamoto S, Umeda M, Kawashita Y, Saito I, Hasegawa T, Komori T, Ueda N, Kirita T, Yamada SI, Kurita H, Senga Y, Shibuya Y, Iwai H.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol

      Volume: 124 Pages: 139-145

    • DOI

      10.1016/j.oooo.2017.04.012

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11202, KAKENHI-PROJECT-16K11878
  • [Journal Article] Transcutaneous carbon dioxide suppresses epithelial-mesenchymal transition in oral squamous cell carcinoma.2016

    • Author(s)
      Iwata E, Hasegawa T, Takeda D, Ueha T, Kawamoto T, Akisue T, Sakai Y, Komori T.
    • Journal Title

      Int J Oncol.

      Volume: 48 Pages: 1493-1498

    • DOI

      10.3892/ijo.2016.3380

    • NAID

      120005866874

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26293337, KAKENHI-PROJECT-26462265, KAKENHI-PROJECT-15K20521
  • [Journal Article] Transcutaneous carbon dioxide induces mitochondrial apoptosis and suppresses metastasis of oral squamous cell carcinoma in vivo.2014

    • Author(s)
      Takeda D, Hasegawa T, Ueha T, Imai Y, Sakakibara A, Minoda M, Kawamoto T, Minamikawa T, Shibuya Y, Akisue T, Sakai Y, Kurosaka M, Komori T.
    • Journal Title

      PLoS One.

      Volume: 9

    • DOI

      10.1371/journal.pone.0100530

    • NAID

      120005611288

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24593028, KAKENHI-PROJECT-24792209
  • [Presentation] 炭酸ガスを使用した効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果2019

    • Author(s)
      長谷川巧実、武田大介、斉藤 泉、岩田英治、筧康正、榊原晶子、明石昌也、南川勉、古森孝英
    • Organizer
      第37回日本口腔腫瘍学会総会
    • Data Source
      KAKENHI-PROJECT-18K09788
  • [Presentation] 効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果2018

    • Author(s)
      長谷川巧実、武田大介、斉藤泉、岩田英治、筧 康正、榊原晶子、明石昌也、南川勉、古森孝英
    • Organizer
      第63回日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-18K09788
  • [Presentation] 口腔癌放射線治療における新規併用療法の開発.2017

    • Author(s)
      岩田英治,長谷川巧実,武田大介,斎藤 泉、有本智美、明石昌也、南川 勉、古森孝英.
    • Organizer
      第35回日本口腔腫瘍学会総会・学術大会,福岡.
    • Data Source
      KAKENHI-PROJECT-15K20521
  • [Presentation] 経皮的炭酸ガス投与による口腔癌上皮間葉移行の抑制効果2015

    • Author(s)
      岩田英治,長谷川巧実,武田大介,明石昌也,南川 勉,古森孝英
    • Organizer
      第60回日本口腔外科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-15K20521
  • [Presentation] ミトコンドリア経路に関連した口腔癌新規治療法の開発2013

    • Author(s)
      武田大介、長谷川巧実、今井佑輔、榊原晶子、重田崇至、南川 勉、渋谷恭之、古森孝英.
    • Organizer
      題58回日本口腔外科学会総会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24792209
  • [Presentation] ミトコンドリア経路に関連した口腔癌新規治療法の開発

    • Author(s)
      武田大介、長谷川巧実、今井佑輔、榊原晶子、明石昌也、南川 勉、渋谷恭之、古森孝英
    • Organizer
      第59回日本口腔外科学会総会・学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-17 – 2014-10-19
    • Data Source
      KAKENHI-PROJECT-24792209
  • 1.  梅田 正博 (60301280)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 2.  Yamada Shin-ichi (50380853)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  KOJIMA Yuka (70720655)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 4.  SOUTOME Sakiko (20325799)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  桐田 忠昭 (70201465)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  柳本 惣市 (10315260)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  武田 大介 (80755637)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 8.  上田 順宏 (40571005)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  渋谷 恭之 (90335430)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  栗田 浩 (10273103)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  明石 昌也 (40597168)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 12.  UEHA Takeshi
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 13.  KOMORI Takahide
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 14.  池田 通 (00211029)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  中村 聡明 (60420452)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  藤澤 琢郎 (20330201)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  山口 泰平 (80230358)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  大倉 正也 (10281130)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  太田 嘉英 (60233152)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  野口 一馬 (50309473)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  寺田 友紀 (00340977)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  山根木 康嗣 (00434944)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  岸本 裕充 (30291818)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  鵜澤 成一 (30345285)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  中野 芳朗 (30360267)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  木本 明 (30597167)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  筧 康正 (70772896)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  岩井 大 (10232638)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 29.  船原 まどか (60796811)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  榊原 晶子 (00569866)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  榊原 俊介 (50444592)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  楠元 順哉 (00870205)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  KAWAMOTO Teruya
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 34.  IWATA Eiji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 35.  SAKAI Yoshitada
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 36.  秋末 敏宏
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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