HASEGAWA TAKUMI 長谷川巧実

Researcher Number	50546497
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 神戸大学, 医学研究科, 准教授 2018 – 2022: 神戸大学, 医学部附属病院, 助教 2019 – 2021: 神戸大学, 医学研究科, 講師 2016 – 2017: 神戸大学, 医学研究科, 助教 2014 – 2015: 神戸大学, 医学(系)研究科(研究院), 助教 2013: 神戸大学, 医学部附属病院, 助教 2012: 神戸大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Social dentistry / Basic Section 57080:Social dentistry-related / Basic Section 57020:Oral pathobiological science-related
Keywords	Principal Investigator 口腔癌 / 炭酸ガス / 転移 / 扁平上皮癌 / 癌関連線維芽細胞 / 副作用 / 放射線抵抗性 / 低酸素環境 / 放射線治療 / 治療抵抗性 / 放射線 / 低酸素 … More Except Principal Investigator … More 口腔癌 / 被膜外浸潤 / 頸部リンパ節転移 / PD-L1 / 多施設共同研究 / 顎骨壊死 / 抜歯 / リキッドバイオプシー / 遠隔転移 / 循環腫瘍DNA / 循環腫瘍細胞 / インスリン抵抗性 / ミトコンドリア機能不全 / 筋肉量減少 / 口腔がん / がん悪液質 / 免疫学的解析 / TRPイオンチャネル / TRPVイオンチャネル / 分子生物学的検討 / 扁平上皮癌 / 個別化治療 / G8 / 高齢者 / 多施設共同前向き研究 / 骨代謝 / 休薬期間 / 骨抑制吸収薬 / 口腔衛生状態 / 局所感染 / 破骨細胞 / 休薬 / 骨吸収抑制薬 / 口腔衛生管理 / 発症予防 / 薬剤関連顎骨壊死 / 口腔感染症 / リンパ管新生 / 血管新生 / 歯性感染症 / 骨髄炎 / 細胞培養 / 分子標的薬 / オルガノイド / 培養細胞 / 新規分子標的薬 / 新規分子標的治療 / 発癌メカニズム / バイオマーカー / 融合遺伝子 / 粘表皮癌 / 唾液腺癌 / 進展メカニズム / 進展度分類 / リンパ節転移 / 頸部リンパ節 / PD-LI / 口腔扁平上皮癌 / 他施設共同研究 / 放射線多発う蝕 / 放射線う蝕 / 歯学 / 放射線治療 / 根尖病巣 / リスク因子 / 頭頸部がん / 放射線性顎骨壊死 Less

Immunological investigation of extracapsular spread mechanism of oral squamous cell carcinoma cervical lymph node metastasis
- Principal Investigator
  
  山田慎一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  University of Toyama
がん悪液質を想定した筋肉量減少に対するミトコンドリア機能改善を介した新規治療法
- Principal Investigator
  
  武田大介
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kobe University
顎骨壊死に対する腐骨分離促進療法の探索
- Principal Investigator
  
  明石昌也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kobe University
ミトコンドリアの正常化と癌関連線維芽細胞の再教育を目指した新規口腔癌治療法の開発Principal Investigator
- Principal Investigator
  
  長谷川巧実
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kobe University
Multicenter study of circulating tumor cells and circulating tumor DNA involved in distant metastasis of oral cancer
- Principal Investigator
  
  柳本惣市
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hiroshima University
Molecular biological analysis of extracapsular spread of cervical lymph node metastasis in oral squamous cell carcinoma/
- Principal Investigator
  
  Yamada Shin-ichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  University of Toyama
環境因子による細胞内シグナル増強と腫瘍悪性化についての相関の解明
- Principal Investigator
  
  榊原晶子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kobe University
Analysis of fusion gene of salivary gland carcinogenesis and explore the molecular target agents
- Principal Investigator
  
  Noguchi Kazuma
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Hyogo Medical University
Elucidation of the mechanisms of transition from odontogenic infection to osteomyelitis of the jaw focusing on angiogenesis and lymphangiogenesis
- Principal Investigator
  
  Akashi Masaya
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kobe University
A multicenter prospective study for elucidating the risk factors and establishing prevention methods of medical-related osteonecrosis of the jaws (MRONJ) .
- Principal Investigator
  
  KOJIMA Yuka
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Kansai Medical University
Molecular biological analysis of extracapsular spread of cervical lymph node metastasis in oral squamous cell carcinoma/
- Principal Investigator
  
  Yamada Shin-ichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Shinshu University
Development of cancer therapies to improve resistance and reduce side effectsPrincipal Investigator
- Principal Investigator
  
  Hasegawa Takumi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kobe University
Prevention and mechanism of radiation-ralated dental caries: Muiticenter randomized contoroled trial
- Principal Investigator
  
  SOUTOME Sakiko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Nagasaki University
A multicenter study of elucidation of status and risk factors of osteoradionecrosis of the jaw
- Principal Investigator
  
  KOJIMA Yuka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Kansai Medical University
Transcutaneous carbon dioxide induces suppresses metastasis of oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  HASEGAWA TAKUMI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kobe University
Development of the new treatment in oral cancer related to mitochondrial apoptosisPrincipal Investigator
- Principal Investigator
  
  HASEGAWA TAKUMI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kobe University

All 2023 2022 2021 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Transcutaneous carbon dioxide application suppresses the expression of cancer-associated fibroblasts markers in oral squamous cell carcinoma xenograft mouse model2023
- Author(s)
  Tadokoro Yoshiaki、Takeda Daisuke、Murakami Aki、Yatagai Nanae、Saito Izumi、Arimoto Satomi、Kakei Yasumasa、Akashi Masaya、Hasegawa Takumi
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 8 Pages: e0290357-e0290357
- DOI
  10.1371/journal.pone.0290357
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10193
[Journal Article] Relationship of Mitochondrial-Related Protein Expression with the Differentiation, Metastasis, and Poor Prognosis of Oral Squamous Cell Carcinoma2023
- Author(s)
  Murakami Aki、Takeda Daisuke、Hirota Junya、Saito Izumi、Amano-Iga Rika、Yatagai Nanae、Arimoto Satomi、Kakei Yasumasa、Akashi Masaya、Hasegawa Takumi
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 16 Pages: 4071-4071
- DOI
  10.3390/cancers15164071
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10193
[Journal Article] The Efficacy of Carbon Dioxide Paste in Alleviating Pain in Patients After Neck Dissection: Protocol for a Double-Blinded, Randomized Controlled Trial2023
- Author(s)
  Tadokoro Yoshiaki、Takeda Daisuke、Saito Izumi、Yatagai Nanae、Kakei Yasumasa、Akashi Masaya、Hasegawa Takumi
- Journal Title
  
  JMIR Research Protocols
  
  Volume: 12 Pages: e50500-e50500
- DOI
  10.2196/50500
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K21014, KAKENHI-PROJECT-22K10193
[Journal Article] Exploratory clinical trial to evaluate the efficacy and safety of carbon dioxide paste in healthy people2022
- Author(s)
  Yatagai Nanae、Hasegawa Takumi、Kyotani Katsusuke、Noda Tomohiro、Amano Rika、Saito Izumi、Arimoto Satomi、Takeda Daisuke、Kakei Yasumasa、Akashi Masaya
- Journal Title
  
  Medicine
  
  Volume: 101 Issue: 29 Pages: e29511-e29511
- DOI
  10.1097/md.0000000000029511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K10193, KAKENHI-PROJECT-22K21014, KAKENHI-PROJECT-19K19156
[Journal Article] Local application of a transcutaneous carbon dioxide paste prevents excessive scarring and promotes muscle regeneration in a bupivacaine‐induced rat model of muscle injury2022
- Author(s)
  Hirota Junya、Hasegawa Takumi、Inui Atsuyuki、Takeda Daisuke、Amano‐Iga Rika、Yatagai Nanae、Saito Izumi、Arimoto Satomi、Akashi Masaya
- Journal Title
  
  International Wound Journal
  
  Volume: 20 Issue: 4 Pages: 1151-1159
- DOI
  10.1111/iwj.13974
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10193, KAKENHI-PROJECT-22K21014, KAKENHI-PROJECT-19K19156
[Journal Article] Bacterial Colonization of the Condyle in Patients with Advanced Mandibular Osteoradionecrosis: Analysis of Hemimandibulectomy Specimens2021
- Author(s)
  Takeda Daisuke、Hashikawa Kazunobu、Shigeoka Manabu、Kanzawa Maki、Yatagai Nanae、Arimoto Satomi、Kusumoto Junya、Hasegawa Takumi、Terashi Hiroto、Akashi Masaya
- Journal Title
  
  International Journal of Dentistry
  
  Volume: 2021 Pages: 1-8
- DOI
  10.1155/2021/9998397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10331
[Journal Article] Local Application of Transcutaneous Carbon Dioxide Paste Decreases Inflammation and Accelerates Wound Healing2021
- Author(s)
  Amano-Iga Rika、Hasegawa Takumi、Takeda Daisuke、Murakami Aki、Yatagai Nanae、Saito Izumi、Arimoto Satomi、Kakei Yasumasa、Sakakibara Akiko、Akashi Masaya
- Journal Title
  
  Cureus
  
  Volume: 13
- DOI
  10.7759/cureus.19518
- NAID
  120007179182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09788, KAKENHI-PROJECT-19K19156
[Journal Article] Transcutaneous Carbon Dioxide Decreases Immunosuppressive Factors in Squamous Cell Carcinoma In Vivo2021
- Author(s)
  Yatagai Nanae、Hasegawa Takumi、Amano Rika、Saito Izumi、Arimoto Satomi、Takeda Daisuke、Kakei Yasumasa、Akashi Masaya
- Journal Title
  
  BioMed Research International
  
  Volume: 5568428 Issue: 1 Pages: 1-9
- DOI
  10.1155/2021/5568428
- NAID
  120007125723
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09788, KAKENHI-PROJECT-19K19156
[Journal Article] Relationship between dental status and development of osteoradionecrosis of the jaw: a multicenter retrospective study.2017
- Author(s)
  Kojima Y, Yanamoto S, Umeda M, Kawashita Y, Saito I, Hasegawa T, Komori T, Ueda N, Kirita T, Yamada SI, Kurita H, Senga Y, Shibuya Y, Iwai H.
- Journal Title
  
  Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
  
  Volume: 124 Issue: 2 Pages: 139-145
- DOI
  10.1016/j.oooo.2017.04.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11202, KAKENHI-PROJECT-16K11878
[Journal Article] Transcutaneous carbon dioxide suppresses epithelial-mesenchymal transition in oral squamous cell carcinoma.2016
- Author(s)
  Iwata E, Hasegawa T, Takeda D, Ueha T, Kawamoto T, Akisue T, Sakai Y, Komori T.
- Journal Title
  
  Int J Oncol
  
  Volume: 48 Issue: 4 Pages: 1493-8
- DOI
  10.3892/ijo.2016.3380
- NAID
  120005866874
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293337, KAKENHI-PROJECT-26462265, KAKENHI-PROJECT-15K20521
[Journal Article] Transcutaneous Carbon Dioxide Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma In Vivo．2014
- Author(s)
  Takeda D, Hasegawa T, Ueha T, Imai Y, Sakakibara A, Minoda M, Kawamoto T, Minamikawa T, Shibuya Y, Akisue T, Sakai Y, Kurosaka M, Komori T．
- Journal Title
  
  PLOS ONE
  
  Volume: 9 Issue: 7 Pages: e100530-e100530
- DOI
  10.1371/journal.pone.0100530
- NAID
  120005611288
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24593028, KAKENHI-PROJECT-24792209
[Presentation] 口腔扁平上皮癌におけるミトコンドリア関連タンパク質発現と分化、転移、予後との関係．2023
- Author(s)
  村上明希，長谷川巧実，武田大介，廣田純也，黒澤泉，伊賀利香，八谷奈苗，有本智美，筧康正，明石昌也
- Organizer
  第68回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K10193
[Presentation] がん関連線維芽細胞マーカーの発現抑制に着目した炭酸ガス吸収療法による抗腫瘍効果の検討.2023
- Author(s)
  田所慶誠, 長谷川巧実, 廣田純也, 村上明希, 佐々木亜紀, 武田大介, 筧康正, 明石昌也.
- Organizer
  第68回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K10193
[Presentation] 局所的炭酸ガス投与による口腔扁平上皮癌の腫瘍免疫抑制に対する改善効果2022
- Author(s)
  八谷奈苗，長谷川巧実，武田大介，筧　康正，榊原晶子，明石昌也．
- Organizer
  第76回日本口腔科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K10193
[Presentation] 炭酸ガスを使用した効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果2019
- Author(s)
  長谷川巧実、武田大介、斉藤　泉、岩田英治、筧康正、榊原晶子、明石昌也、南川勉、古森孝英
- Organizer
  第37回日本口腔腫瘍学会総会
- Data Source
  KAKENHI-PROJECT-18K09788
[Presentation] 効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果2018
- Author(s)
  長谷川巧実、武田大介、斉藤泉、岩田英治、筧　康正、榊原晶子、明石昌也、南川勉、古森孝英
- Organizer
  第63回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-18K09788
[Presentation] 口腔癌放射線治療における新規併用療法の開発．2017
- Author(s)
  岩田英治，長谷川巧実，武田大介，斎藤　泉、有本智美、明石昌也、南川　勉、古森孝英．
- Organizer
  第35回日本口腔腫瘍学会総会・学術大会，福岡．
- Data Source
  KAKENHI-PROJECT-15K20521
[Presentation] 経皮的炭酸ガス投与による口腔癌上皮間葉移行の抑制効果2015
- Author(s)
  岩田英治，長谷川巧実，武田大介，明石昌也，南川　勉，古森孝英
- Organizer
  第60回日本口腔外科学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K20521
[Presentation] ミトコンドリア経路に関連した口腔癌新規治療法の開発2013
- Author(s)
  武田大介、長谷川巧実、今井佑輔、榊原晶子、重田崇至、南川　勉、渋谷恭之、古森孝英．
- Organizer
  題58回日本口腔外科学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24792209
[Presentation] ミトコンドリア経路に関連した口腔癌新規治療法の開発
- Author(s)
  武田大介、長谷川巧実、今井佑輔、榊原晶子、明石昌也、南川　勉、渋谷恭之、古森孝英
- Organizer
  第59回日本口腔外科学会総会・学術大会
- Place of Presentation
  千葉
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-24792209

1. Yamada Shin-ichi (50380853)

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2. 梅田正博 (60301280)

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35. 有本智美 (20841042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 鳴瀬智史 (70549609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 本田一文 (10260936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 上田倫弘 (80839910)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. KAWAMOTO Teruya

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
40. IWATA Eiji

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
41. SAKAI Yoshitada

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. LEE Sangyang

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 秋末敏宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HASEGAWA TAKUMI 長谷川 巧実

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ミトコンドリアの正常化と癌関連線維芽細胞の再教育を目指した新規口腔癌治療法の開発Principal Investigator

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Development of cancer therapies to improve resistance and reduce side effectsPrincipal Investigator

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Transcutaneous carbon dioxide induces suppresses metastasis of oral squamous cell carcinomaPrincipal Investigator

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HASEGAWA TAKUMI 長谷川巧実