shimakami tetsuro 島上哲朗

… Alternative Names

SHIMAKAMI Tetsuro 島上哲朗

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Researcher Number	50436820
Other IDs
External Links
Affiliation (Current)	2025: 金沢大学, 医学系, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 金沢大学, 保健管理センター, 助教 2020 – 2023: 金沢大学, 附属病院, 特任教授 2017: 金沢大学, 大学病院, その他 2016 – 2017: 金沢大学, 附属病院, 特任教授 2015: 金沢大学, 附属病院, 助教 2012 – 2015: 金沢大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Virology / Gastroenterology Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator B型肝炎ウイルス / C型慢性肝炎 / C型肝炎ウイルス / 肝がん / 肝硬変 / D型肝炎ウイルス / ノンコーディングRNA / 長鎖ノンコーディングRNA / マイクロRNA122 / 抗ウイルス療法 / microRNA-122 … More Except Principal Investigator … More 癌 / 循環腫瘍細胞 / 免疫チェックポイント阻害薬 / ドライバー遺伝子 / 転移 / 肝細胞がん / メチル化 / shear stress / 血管内皮 / マイクロアレイ / ゲノム / ウイルス / 感染症 / 自然免疫 / 幹細胞マーカー / ウイルス培養細胞 Less

新規モニタリング法の確立によるB型肝炎ウイルスを完全駆除する薬物の探索と同定Principal Investigator
- Principal Investigator
  
  島上哲朗
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kanazawa University
Identification of driver genes controlling metastatic potential in the evolution of hepatocellular carcinoma
- Principal Investigator
  
  中本安成
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  University of Fukui
Investigation on Molecular Mechanisms of Liver Diseases Caused by Hepatitis B and D Viruses CoinfectionPrincipal Investigator
- Principal Investigator
  
  島上哲朗
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Kanazawa University
Control of Chronic Liver Diseases due to Hepatitis C Virus by Long Non-coding RNAsPrincipal Investigator
- Principal Investigator
  
  Shimakami Tetsuro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kanazawa University
Identification of biomarkers to predict HCC development after successful treatment of viral hepatitis
- Principal Investigator
  
  HONDA Masao
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Establishment new HCC derived cell lines that support efficient hepatitis virus replication.
- Principal Investigator
  
  HONDA Masao
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University
Clarification of Mechanism of Anti-microRNA-122 Therapy for Hepatitis C Virus InfectionPrincipal Investigator
- Principal Investigator
  
  SHIMAKAMI Tetsuro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kanazawa University

All 2023 2022 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Book

[Book] 消化器の臨床2016
- Author(s)
  島上哲朗、金子周一
- Total Pages
  7
- Publisher
  ヴァンメディカル
- Data Source
  KAKENHI-PROJECT-15K08492
[Journal Article] A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes2022
- Author(s)
  Sumiyadorj Ariunaa、Murai Kazuhisa、Shimakami Tetsuro、Kuroki Kazuyuki、Nishikawa Tomoki、Kakuya Masaki、Yamada Atsumu、Wang Ying、Ishida Atsuya、Shirasaki Takayoshi、Kawase Shotaro、Li Ying‐Yi、Okada Hikari、Nio Kouki、Kawaguchi Kazunori、Honda Masao、Kaneko Shuichi
- Journal Title
  
  Hepatology Communications
  
  Volume: 6 Issue: 9 Pages: 2441-2454
- DOI
  10.1002/hep4.2018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07940, KAKENHI-PROJECT-20KK0178
[Journal Article] Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro.2018
- Author(s)
  1.Murai K, Shirasaki T, Honda M, Shimizu R, Shimakami T, Nakasho S, Shirasaki N, Okada H, Sakai Y, Yamashita T, Kaneko S.
- Journal Title
  
  International Journal of Molecular Sciences.
  
  Volume: 19(2) Issue: 2 Pages: 108-108
- DOI
  10.3390/ijms19020108
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-16H04695
[Journal Article] Unexpected Replication Boost by Simeprevir for Simeprevir-resistant Variants in Genotype 1a Hepatitis C Virus2018
- Author(s)
  Murai K, Shimakami T, Welsch C, Shirasaki T, Liu F, Kitabayashi J, Tanaka S, Funaki M, Omura H, Nishikawa T, Suminyadorj A, Honda M, Kaneko S.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 印刷中 Issue: 7
- DOI
  10.1128/aac.02601-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-18H02793, KAKENHI-PROJECT-16K21058
[Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.2017
- Author(s)
  Funaki M, Kitabayashi J, Shimakami T, Nagata N, Sakai Y, Takegoshi K, Okada H, Murai K, Shirasaki T, Oyama T, Yamashita T, Ota T, Takuwa Y, Honda M, Kaneko S.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 16978-16978
- DOI
  10.1038/s41598-017-17285-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PROJECT-15H04673, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H03035, KAKENHI-PROJECT-15K08492
[Journal Article] Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B.2017
- Author(s)
  Kawaguchi K, Honda M, Ohta H, Terashima T, Shimakami T, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Komura T, Unoura M, Kaneko S
- Journal Title
  
  J Gastroenterol
  
  Volume: ePub ahead Issue: 6 Pages: 740-751
- DOI
  10.1007/s00535-017-1386-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-17K09414, KAKENHI-PROJECT-17K15934, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-18H02793
[Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet2017
- Author(s)
  Okada H, Takabatake R, Honda M, Takegoshi K, Yamashita T, Nakamura M, Shirasaki T, Sakai Y, Shimakami T, Nagata N, Takamura T, Tanaka T, Kaneko S.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 25 Pages: 39978-39993
- DOI
  10.18632/oncotarget.18116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09413, KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-17K15933, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-15H04809
[Journal Article] Reactivation of hepatitis B virus from an isolated anti-HBc positive patient after eradication of hepatitis C virus with direct-acting antiviral agents2017
- Author(s)
  Suda Tsuyoshi、Shimakami Tetsuro、Shirasaki Takayoshi、Yamashita Tatsuya、Mizukoshi Eishiro、Honda Masao、Kaneko Shuichi
- Journal Title
  
  J Hepatol
  
  Volume: 67 Issue: 5 Pages: 1108-1111
- DOI
  10.1016/j.jhep.2017.07.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21058, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492
[Journal Article] Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3' variants.2017
- Author(s)
  Yamane D, Selitsky SR, Shimakami T, Li Y, Zhou M, Honda M, Sethupathy P, Lemon SM.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: - Pages: 4743-4755
- DOI
  10.1093/nar/gkw1332
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H07462, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-15K08492
[Journal Article] Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B.2017
- Author(s)
  Wang X, Oishi N, Shimakami T, Yamashita T, Honda M, Murakami S, Kaneko S.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 23 Issue: 18 Pages: 3252-3261
- DOI
  10.3748/wjg.v23.i18.3252
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-15K08992
[Journal Article] Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model.2017
- Author(s)
  K Takegoshi, M Honda, H Okada, R Takabatake, N Matsuzawa-Nagata, JS Campbell, M Nishikawa, T Shimakami, T Shirasaki, Y Sakai, T Yamashita, T Takamura, T Tanaka, S Kaneko.
- Journal Title
  
  Oncotarget
  
  Volume: 印刷中 Issue: 11 Pages: 18191-18205
- DOI
  10.18632/oncotarget.15304
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K21058
[Journal Article] Efficient Suppression of Hepatitis C Virus Replication by Combination Treatment with miR-122 Antagonism and Direct-acting Antivirals in Cell Culture Systems.2016
- Author(s)
  Liu F, Shimakami T, Murai K, Shirasaki T, Funaki M, Honda M, Murakami S, Yi M, Tang H, Kaneko S.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 30939-30939
- DOI
  10.1038/srep30939
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-15K08492, KAKENHI-PROJECT-16K21058
[Journal Article] Hepatitis B Virus (HBV) Core-Related Antigen During Nucleos(t)ide Analog Therapy Is Related to Intra-hepatic HBV Replication and Development of Hepatocellular Carcinoma.2016
- Author(s)
  Honda M, Shirasaki T, Terashima T, Kawaguchi K, Nakamura M, Oishi N, Wang X, Shimakami T, Okada H, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S.
- Journal Title
  
  J Infect Dis
  
  Volume: 213 Issue: 7 Pages: 1096-1106
- DOI
  10.1093/infdis/jiv572
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460995, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H06827, KAKENHI-PROJECT-16K15426, KAKENHI-PROJECT-16K21058
[Journal Article] Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C.2015
- Author(s)
  Selitsky SR, Baran-Gale J, Honda M, Yamane D, Masaki T, Fannin EE, Guerra B, Shirasaki T, Shimakami T, Kaneko S, Lanford RE, Lemon SM, Sethupathy P.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Issue: 1 Pages: 7675-7675
- DOI
  10.1038/srep07675
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24790687, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-26670378
[Journal Article] Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin 28B genotypes2014
- Author(s)
  M Honda, T Shirasaki, T Shimakami, A Sakai, R Horii, K Arai, T Yamashita, Y Sakai, T Yamashita, H Okada, K Murai, M Nakamura, E Mizukoshi, S Kaneko
- Journal Title
  
  Hepatology
  
  Volume: 59(3) Issue: 3 Pages: 828-38
- DOI
  10.1002/hep.26788
- NAID
  120005447749
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249042, KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-26670378
[Journal Article] Regulation of the hepatitis C virus RNA replicase by2014
- Author(s)
  Yamane D, McGivern DR, Wauthier E, Yi M, Madden VJ, Welsch C, Antes I, Wen Y, Chugh PE, McGee CE, Widman DG, Misumi I, Bandyopadhyay S, Kim S, Shimakami T, Oikawa T, Whitmire JK, Heise MT, Dittmer DP, Kao CC, Pitson SM, Merrill AH Jr, Reid LM, Lemon SM.
- Journal Title
  
  Nature Medicine
  
  Volume: 20 Issue: 8 Pages: 927-35
- DOI
  10.1038/nm.3610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790687
[Journal Article] hnRNP L and NF90 interact with hepatitis C virus 5'-terminal untranslated RNA and promote efficient replication.2014
- Author(s)
  Li Y, Masaki T, Shimakami T, Lemon SM.
- Journal Title
  
  Journal of Virology
  
  Volume: 88 Issue: 13 Pages: 7199-209
- DOI
  10.1128/jvi.00225-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790687
[Journal Article] Impaired interferon signaling in chronic hepatitis C patients with advanced fibrosis via the transforming growth factor beta signaling pathway.2014
- Author(s)
  Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Okada H, Takabatake R, Tokumaru A, Sakai Y, Yamashita T, Lemon SM, Murakami S, Kaneko S.
- Journal Title
  
  Hepatology.
  
  Volume: 60(5) Issue: 5 Pages: 1519-30
- DOI
  10.1002/hep.27277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24790687, KAKENHI-PROJECT-26670378
[Journal Article] The acyclic retinoid peretinoin inhibits hepatitis C virus replication and infectious virus release in vitro.2014
- Author(s)
  Shimakami T, Honda M, Shirasaki T, Takabatake R, Liu F, Murai K, Shiomoto T, Funaki M, Yamane D, Murakami S, Lemon SM, Kaneko S.
- Journal Title
  
  Sci Rep.
  
  Volume: 4 Issue: 1 Pages: 4688-4688
- DOI
  10.1038/srep04688
- NAID
  120005774911
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24790687, KAKENHI-PROJECT-26670378
[Journal Article] microRNA-122 Abundance in Hepatocellular Carcinoma and Non-Tumor Liver Tissue from Japanese Patients with Persistent HCV versus HBV Infection.2013
- Author(s)
  Spaniel C, Honda M, Selitsky SR, Yamane D, Shimakami T, Kaneko S, Lanford RE, Lemon SM.
- Journal Title
  
  PLoS One
  
  Volume: 8(10) Issue: 10 Pages: e76867-e76867
- DOI
  10.1371/journal.pone.0076867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390187, KAKENHI-PROJECT-24790687
[Journal Article] Base pairing between hepatitis C virus RNA and microRNA 122 3' of its seed sequence is essential for genome stabilization and production of infectious virus2012
- Author(s)
  Shimakami T, Yamane D, Welsch C, Hensley L, Jangra RK, Lemon SM
- Journal Title
  
  Journal of Virology
  
  Volume: 86 Pages: 7372-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790687
[Presentation] Development of HDV Replication and Infection Monitoring System by Inserting a Reporter Gene into the HDV Genome2023
- Author(s)
  Sumiyadorj Ariunaa, Tetsuro Shimakami, Taro Yamashita
- Organizer
  第31回日本抗ウイルス療法学会
- Data Source
  KAKENHI-PROJECT-20KK0178
[Presentation] Unexpected Enhancement of Replication Capacity by Simeprevir for Simeprevir-resistant Variants in Genotype 1a Hepatitis C Virus2017
- Author(s)
  Tetsuro Shimakami, Kazuhisa Murai, Christoph Welsch, Takayosi Shirasaki, Masao Honda, and Shuichi Kaneko
- Organizer
  The Liver Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08492
[Presentation] Nucleos(t)ide analogues and interferon affect intranuclear HBV genome in vitro via Notch signaling modification, independent of the ubiquitin-proteasome system2017
- Author(s)
  Kazunori Kawaguchi, Zijing Wang, Masao Honda, Takayoshi Shirasaki, Hikari Okada, Tetsuro Shimakami, Kouki Nio, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Genome-wide methylation analysis identified a new intrahepatic angiogenesis marker associated with induction of tumorigenesis after successful eradication of HCV2017
- Author(s)
  Masashi Nishikawa, Masao Honda, Hikari Okada, Kazunori Kawaguchi, Rika Horii, Tetsuro Shimakami, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, and Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] MicroRNA-10a is associated with the impaired liver functions in patients with advanced stage of chronic hepatitis C2017
- Author(s)
  Rika Horii, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Ryogo Shimizu, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] アスナプレビル・ダクラタスビル療法の治療効果と非著効例に対するレジパスビル・ソフォスブビルの治療効果に関する検討2017
- Author(s)
  島上哲朗，本多政夫，金子周一
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-15K08492
[Presentation] Notch signaling inhibition is associated with degradation of intrahepatic HBV by ITCH in an ubiquitin-dependent manner2017
- Author(s)
  Zijing Wang, Kazunori Kawaguchi, Masao Honda, Hikari Okada, Takayoshi Shirasaki, Tetsuro Shimakami, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] IFN-λ3 induces dendritic cell maturation independent of type I IFN2017
- Author(s)
  Shiho Tanaka, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Takayoshi Shirasaki, Seishi Murakami, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] 7. mRNA for selenoprotein P, a hepatokine, binds RIG-I protein and inhibits the RIG-I-mediated type I interferon response2017
- Author(s)
  Kazuhisa Murai, Masao Honda, Tetsuro Shimakami, Takayoshi Shirasaki, Hirofumi Misu, Toshinari Takamura, Stanley M. Lemon, Seishi Murakami, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] 当院における肝移植後C型肝炎ウイルス感染に対するオムビタスビル水和物・パリタプレビル水和物・リトナビル配合錠の使用経験2017
- Author(s)
  島上哲朗，砂子阪肇，金子周一
- Organizer
  第103回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-15K08492
[Presentation] Regulation of Hepatitis C Virus Infection by Long Non-Coding RNA2017
- Author(s)
  Jyuria Kitabayashi, Tetsuro Shimakami, Takayosi Shirasaki, Kazuhisa Murai, Masao Honda, and Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Inhibitory effect of acyclic retinoid on hepatitis B virus replication2017
- Author(s)
  Ryogo Shimizu, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Kazuhisa Murai, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] A liver-derived secretory protein, LECT2, activates plasmacytoid dendritic cells and protects hepatocytes from HBV infection2017
- Author(s)
  Takayoshi Shirasaki, Masao Honda, Kazuhisa Murai, Tetsuro Shimakami, Miwako Narita, Hirofumi Misu, Toshinari Takamura, Seishi Murakami, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Osteopontin regulates IFN signaling and HCV replication in cancer stem cells2017
- Author(s)
  Ryougo Shimizu, Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Taro Yamashita, Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Unexpected Enhancement of Replication Capacity by Simeprevir for Simeprevir-Resistant Variants in Genotype 1a Hepatitis C Virus2017
- Author(s)
  Tetsuro Shimakami, Kazuhisa Murai, Christoph Welsh, Takayosi Shirasaki, Masao Honda, and Shuichi Kaneko
- Organizer
  AASLD 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Unexpected Enhancement of Replication Capacity by Simeprevir for Simeprevir-resistant Variants in Genotype 1a Hepatitis C Virus2017
- Author(s)
  Tetsuro Shimakami, Kazuhisa Murai, Christoph Welsch, Takayosi Shirasaki, Masao Honda, and Shuichi Kaneko
- Organizer
  24th International Symposium on Hepatitis C Virus and Related Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08492
[Presentation] Effective Prevention of Direct-acting Antiviral-resistant Hepatitis C Virus by Combination with Anti-miR-122 Therapy in Cell Culture2016
- Author(s)
  Tetsuro Shimakami, Fanwei Liu, Kazuhisa Murai, Takayoshi Shirasaki, Masao Honda, Shuichi Kaneko
- Organizer
  AASLD 2016
- Place of Presentation
  ボストン
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08492
[Presentation] Regulation of Hepatitis C Virus Infection by Long Non-Coding RNA2015
- Author(s)
  Shimakami T, Honda M, Shirasaki T, Liu F, Funaki M, Murai K, Kaneko S
- Organizer
  The 66th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  サンフランシスコ（アメリカ）
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08492
[Presentation] Effective prevention of direct-acting antiviral-resistant hepatitis C virus by combination with LNA-anti-miR-122 therapy in cell culture2015
- Author(s)
  Fanwei Liu, Tetsuro Shimakami, Kazuhisa Murai, Takayuki Shirasaki, Masaya Funaki, Masao Honda, Hong Tang, Seishi Murakami, Shuichi Kaneko
- Organizer
  22nd International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  ストラスブール（フランス）
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04809
[Presentation] Regulation of Hepatitis C Virus Infection by Long Non-Coding RNA2015
- Author(s)
  Shimakami T, Honda M, Shirasaki T, Liu F, Funaki M, Murai K, Ooishi N, Kaneko S
- Organizer
  22nd International Symposium on Hepatitis C Viruses and Related Viruses
- Place of Presentation
  ストラスブール（フランス）
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08492
[Presentation] Effective prevention of direct-acting antiviral-resistant hepatitis C virus by combination with LNA-anti-miR-122 therapy in cell culture2015
- Author(s)
  Fanwei Liu, Tetsuro Shimakami, Kazuhisa Murai, Takayuki Shirasaki, Masaya Funaki, Masao Honda, Hong Tang, Seishi Murakami, Shuichi Kaneko
- Organizer
  22nd International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  ストラスブール（フランス）
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670378
[Presentation] LECT2 Specifically Induced by IL28B Regulates Interferon Response and HCV Replication.2014
- Author(s)
  Shirasaki T, Honda M, Shimakami T, Murai K, Shiomoto T, Misu H, Takamura T, Lemon SM, Murakami S, Kaneko S.
- Organizer
  21st International Symposium on Hepatitis C Viruses (HCV2014)
- Place of Presentation
  バンフ（カナダ）
- Year and Date
  2014-09-09
- Data Source
  KAKENHI-PROJECT-26670378
[Presentation] miR-122 stabilizes Hepatitis C Virus RNA by an Ago2-dependent mechanism2012
- Author(s)
  Tetsuro Shimakami, Daisuke Yamane, Masao Honda, Shuichi Kaneke, and Stanley M Lemon
- Organizer
  The 10th single topic conference (日本肝臓学会）
- Place of Presentation
  京王プラザホテル（東京都）
- Data Source
  KAKENHI-PROJECT-24790687
[Presentation] IL28B Genotype，ISGs発現量，前治療反応を用いたテラプレビル併用抗HCV 療法における治療効果予測と至適治療期間に関する検討
- Author(s)
  島上哲朗、本多政夫、金子周一
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-24790687
[Presentation] ACYCLIC RETINOID, PERETINOIN, INHIBITS HEPATITIS C VIRUS REPLICATION AND INFECTIOUS VIRUS RELEASE IN CELL
- Author(s)
  Shimakami T, Honda M, Shirasaki T, Murakami S, and Kaneko S.
- Organizer
  The 49th Meeting of the European Association for the Study of the Liver
- Place of Presentation
  ロンドン（イギリス）
- Year and Date
  2014-04-09 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-24790687
[Presentation] Regulation of Hepatitis C Virus Infection by Long Non-Coding RNAs.
- Author(s)
  Shimakami T, Honda M, Shirasaki T, Liu F, Funaki M, Murai K, Shiomoto T, Murakami S, and Kaneko S.
- Organizer
  21st International Symposium on Hepatitis C Viruses
- Place of Presentation
  バンフ（カナダ）
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-24790687
[Presentation] Regulation of Hepatitis C Virus Infection by Long Non-Coding RNAs.
- Author(s)
  Shimakami T, Honda M, Shirasaki T, Liu F, Funaki M, Murai K, Shiomoto T, Murakami S, and Kaneko S.
- Organizer
  The Liver Meeting 2014(65th Annual Meeting of the American Association for the Study of Liver Disease)
- Place of Presentation
  ボストン（アメリカ）
- Year and Date
  2014-11-13 – 2014-11-17
- Data Source
  KAKENHI-PROJECT-24790687
[Presentation] 前治療無効例に対するテラプレビル併用3剤併用療法48週間延長投与に関する検討
- Author(s)
  島上哲朗、本多政夫、金子周一
- Organizer
  第100回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2014-04-23 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24790687

1. YAMASHITA Taro (90377432)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. HONDA Masao (00272980)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
3. 村居和寿 (10828099)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SHIRASAKI Takayoshi (50547180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 堀本勝久 (40238803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 善岡克次 (60200937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中本安成 (40293352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 平松活志 (30646849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 野阪拓人 (70748441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAWAGUCHI Kazunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. TAKAMURA Toshinari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 酒井佳夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
13. 金子周一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 岡田光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

shimakami tetsuro 島上 哲朗

SHIMAKAMI Tetsuro 島上 哲朗

Research Projects

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新規モニタリング法の確立によるB型肝炎ウイルスを完全駆除する薬物の探索と同定Principal Investigator

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Identification of driver genes controlling metastatic potential in the evolution of hepatocellular carcinoma

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Investigation on Molecular Mechanisms of Liver Diseases Caused by Hepatitis B and D Viruses CoinfectionPrincipal Investigator

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Control of Chronic Liver Diseases due to Hepatitis C Virus by Long Non-coding RNAsPrincipal Investigator

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Identification of biomarkers to predict HCC development after successful treatment of viral hepatitis

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Establishment new HCC derived cell lines that support efficient hepatitis virus replication.

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Clarification of Mechanism of Anti-microRNA-122 Therapy for Hepatitis C Virus InfectionPrincipal Investigator

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[Book] 消化器の臨床2016

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[Journal Article] A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes2022

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[Journal Article] Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro.2018

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[Journal Article] Unexpected Replication Boost by Simeprevir for Simeprevir-resistant Variants in Genotype 1a Hepatitis C Virus2018

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[Journal Article] Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo.2017

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[Journal Article] Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts hepatocellular carcinoma incidence and recurrence in nucleos(t)ide analogue therapy for chronic hepatitis B.2017

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[Journal Article] Peretinoin, an acyclic retinoid, suppresses steatohepatitis and tumorigenesis by activating autophagy in mice fed an atherogenic high-fat diet2017

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shimakami tetsuro 島上哲朗

SHIMAKAMI Tetsuro 島上哲朗