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Ishida Hidekazu  石田 秀和

ORCIDConnect your ORCID iD *help
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ISHIDA HIDEKAZU  石田 秀和

ISHIDA Hidekazu  石田 秀和

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Researcher Number 50467552
Other IDs
Affiliation (Current) 2025: 大阪大学, 大学院医学系研究科, 講師
Affiliation (based on the past Project Information) *help 2022 – 2024: 大阪大学, 大学院医学系研究科, 講師
2017 – 2021: 大阪大学, 医学系研究科, 助教
2016: 大阪大学, 医学系研究科, 特任助教(常勤)
2015: 大阪大学, 医学(系)研究科(研究院), 特任助教(常勤)
2013: 大阪大学, 医学部附属病院, その他
2013: 大阪大学, 医学部附属病院, 医員
2011 – 2012: 大阪大学, 医学(系)研究科(研究院), 特任助教(常勤)
Review Section/Research Field
Principal Investigator
Cardiovascular medicine / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 53020:Cardiology-related
Except Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 53020:Cardiology-related / Pediatrics
Keywords
Principal Investigator
マウス / 肺動脈性肺高血圧 / 肺高血圧 / モデルマウス / ダウン症候群 / エクソーム解析 / RNA-seq / iPS細胞 / 心筋細胞 / 心筋線維芽細胞 … More / 拘束型心筋症 / 循環器・高血圧 / マーカー / 血管平滑筋細胞 / 血管内皮細胞 / 肺動脈 / レーザーマイクロダイセクション / 次世代シークエンサー / 肺動脈平滑筋細胞 / 肺動脈内皮細胞 / シングルセル解析 / 細胞表面マーカー / 表面マーカー / 次世代シーケンサー / 心筋前駆細胞 … More
Except Principal Investigator
拘束型心筋症 / 心筋線維芽細胞 / iPS細胞 / RNA-seq / 拡張型心筋症 / 心臓移植 / 心筋細胞 / 肺高血圧症 / 3Dイメージング / 空間的トランスクリプトーム解析 / 空間的質量分析 / マルチオミクス解析 / 免疫抑制薬 / 拒絶反応 / 遺伝子治療 / モデルマウス / 粘弾性 / 肺血管拡張薬 / 原子間力顕微鏡 / 肺動脈平滑筋細胞 / 肺動脈性肺高血圧症 / 遺伝子発現解析 / 心筋症 / PAH / cGMP / ナトリウム利尿ペプチド受容体 / CNP Less
  • Research Projects

    (11 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (10 People)
  •  TNNI3変異ノックインモデルマウスを用いた拘束型心筋症の病態解明

    • Principal Investigator
      石井 良
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Osaka University
  •  ダウン症候群に関連する肺動脈性肺高血圧症の病態解明と新規治療薬開発Principal Investigator

    • Principal Investigator
      石田 秀和
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Osaka University
  •  空間マルチオミクス解析と3Dイメージングによる移植心管理の高精度化を目指した研究

    • Principal Investigator
      成田 淳
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Osaka University
  •  心筋細胞と心筋線維芽細胞の相互作用に着目した拘束型心筋症・心室拡張障害の病態解明

    • Principal Investigator
      小垣 滋豊
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Osaka University
  •  Elucidation for the pathogenesis of pediatric dilated cardiomyopathy by focusing on the interaction between cardiomyocytes and cardiac fibroblasts

    • Principal Investigator
      ISHII RYO
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Osaka University
  •  In vitro pharmacological assessment of pulmonary arterial hypertension by atomic force microscopy

    • Principal Investigator
      Kogaki Shigetoyo
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Osaka University
  •  Analysis of pathological mechanisms of restrictive cardiomyopathy by using cardiac fibroblastsPrincipal Investigator

    • Principal Investigator
      Ishida Hidekazu
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Osaka University
  •  Pathological functions of cardiac fibroblasts in pediatric cardiomyopathy

    • Principal Investigator
      ISHII RYO
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Osaka University
  •  Identification of specific marker of human pulmonary arterial endothelial cell and smooth muscle cellPrincipal Investigator

    • Principal Investigator
      ISHIDA HIDEKAZU
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University
  •  Identification of novel surface marker of cardiac progenitor cells for heart regeneration therapyPrincipal Investigator

    • Principal Investigator
      ISHIDA HIDEKAZU
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Osaka University
  •  Type B Human Natriuretic Peptide Receptor with a novel gain-of-function mutation provides therapeutic potential in the treatment of pulmonary arterial hypertension.

    • Principal Investigator
      KOGAKI Shigetoyo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Osaka University

All 2024 2023 2021 2020 2017 2016 2013 2012 2011 Other

All Journal Article Presentation Book

  • [Book] Pulmonary hypertension update2023

    • Author(s)
      石田秀和
    • Total Pages
      90
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-23K07331
  • [Journal Article] Impaired Relaxation in Induced Pluripotent Stem Cell‐Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy2024

    • Author(s)
      Wang Renjie、Hasegawa Moyu、Suginobe Hidehiro、Yoshihara Chika、Ishii Yoichiro、Ueyama Atsuko、Ueda Kazutoshi、Hashimoto Kazuhisa、Hirose Masaki、Ishii Ryo、Narita Jun、Watanabe Takuji、Kawamura Takuji、Taira Masaki、Ueno Takayoshi、Miyagawa Shigeru、Ishida Hidekazu
    • Journal Title

      Journal of the American Heart Association

      Volume: 13 Issue: 6

    • DOI

      10.1161/jaha.123.032375

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08101
  • [Journal Article] Pathogenic Roles of Cardiac Fibroblasts in Pediatric Dilated Cardiomyopathy2023

    • Author(s)
      Tsuru Hirofumi、Yoshihara Chika、Suginobe Hidehiro、Matsumoto Mizuki、Ishii Yoichiro、Narita Jun、Ishii Ryo、Wang Renjie、Ueyama Atsuko、Ueda Kazutoshi、Hirose Masaki、Hashimoto Kazuhisa、Nagano Hiroki、Tanaka Ryosuke、Okajima Takaharu、Ozono Keiichi、Ishida Hidekazu
    • Journal Title

      Journal of the American Heart Association

      Volume: 12 Issue: 13

    • DOI

      10.1161/jaha.123.029676

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K17872, KAKENHI-PROJECT-21K07749, KAKENHI-PROJECT-21H01787
  • [Journal Article] Isogenic pairs of induced-pluripotent stem-derived endothelial cells identify DYRK1A/PPARG/EGR1 pathway is responsible for Down syndrome-associated pulmonary hypertension2023

    • Author(s)
      Suginobe Hidehiro、Ishida Hidekazu、Ishii Yoichiro、Ueda Kazutoshi、Yoshihara Chika、Ueyama Atsuko、Wang Renjie、Tsuru Hirofumi、Hashimoto Kazuhisa、Hirose Masaki、Ishii Ryo、Narita Jun、Kitabatake Yasuji、Ozono Keiichi
    • Journal Title

      Human Molecular Genetics

      Volume: 33 Issue: 1 Pages: 78-90

    • DOI

      10.1093/hmg/ddad162

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K07331
  • [Journal Article] Cardiac Fibroblasts Play Pathogenic Roles in Idiopathic Restrictive Cardiomyopathy2021

    • Author(s)
      Tsuru Hirofumi、Ishida Hidekazu、Narita Jun、Ishii Ryo、Suginobe Hidehiro、Ishii Yoichiro、Wang Renjie、Kogaki Shigetoyo、Taira Masaki、Ueno Takayoshi、Miyashita Yohei、Kioka Hidetaka、Asano Yoshihiro、Sawa Yoshiki、Ozono Keiichi
    • Journal Title

      Circ J

      Volume: 85 Issue: 5 Pages: 677-686

    • DOI

      10.1253/circj.CJ-20-1008

    • NAID

      130008028981

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2021-04-23
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07789, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K17561, KAKENHI-PROJECT-19H03652
  • [Journal Article] Idiopathic Restrictive Cardiomyopathy in Children2021

    • Author(s)
      石田 秀和
    • Journal Title

      Pediatric Cardiology and Cardiac Surgery

      Volume: 37 Issue: 3 Pages: 184-192

    • DOI

      10.9794/jspccs.37.184

    • NAID

      130008140097

    • ISSN
      0911-1794, 2187-2988
    • Year and Date
      2021-11-01
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K17561
  • [Journal Article] Atomic force microscopy identifies cellular elasticity of pulmonary arterial smooth muscle cells in a patient with idiopathic pulmonary arterial hypertension2021

    • Author(s)
      Shinichi Katsuragi, Nao Tatsumi, Mizuki Matsumoto, Jun Narita, Ryo Ishii, Hidehiro Suginobe, Hirofumi Tsuru, Wang Renjie, Shigetoyo Kogaki, Keiichi Ozono, Ryosuke Tanaka, Takaharu Okajima, and Hidekazu Ishida
    • Journal Title

      Cardiology Research

      Volume: 12 Issue: 4 Pages: 231-237

    • DOI

      10.14740/cr1282

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08276, KAKENHI-PROJECT-21H01787
  • [Journal Article] Prognostic factors of premature closure of the ductus arteriosus in utero: a systematic literature review.2017

    • Author(s)
      Ishida H, Kawazu Y, Kayatani F, Inamura N.
    • Journal Title

      Cardiol Young

      Volume: 27 Issue: 4 Pages: 634-638

    • DOI

      10.1017/s1047951116000871

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19403
  • [Journal Article] Converting everolimus to mycophenolate mofetil ameliorated prolonged respiratory syncytial virus infection in a child after heart transplantation2017

    • Author(s)
      Suginobe Hidehiro、Nawa Nobutoshi、Ishida Hidekazu、Kogaki Shigetoyo
    • Journal Title

      BMJ Case Rep.

      Volume: X Pages: 220342-220342

    • DOI

      10.1136/bcr-2017-220342

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19403
  • [Presentation] ダウン症候群に合併する肺高血圧2024

    • Author(s)
      石田秀和
    • Organizer
      第15回日本小児循環器学会教育セミナーアドバンスドコース
    • Invited
    • Data Source
      KAKENHI-PROJECT-23K07331
  • [Presentation] DYRK1A/PPARG/EGR1 pathway elicits endothelial dysfunctions and predispose to developing pulmonary hypertension in Down syndrome.2023

    • Author(s)
      杉辺英世、石田秀和
    • Organizer
      AHA Scientific Session 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K07331
  • [Presentation] 小児拡張型心筋症の病態形成における 心筋線維芽細胞の役割2023

    • Author(s)
      石田 秀和、石井 良
    • Organizer
      日本小児心筋疾患学会
    • Data Source
      KAKENHI-PROJECT-21K07749
  • [Presentation] 心移植後患者における免疫抑制薬の心筋組織中濃度と血中濃度および拒絶との関連性2023

    • Author(s)
      橋本和久、石田秀和、成田淳
    • Organizer
      第59回日本小児循環器学会
    • Data Source
      KAKENHI-PROJECT-23K07530
  • [Presentation] 小児心筋症における心筋線維芽細胞の生理機能ならびに病態関与の解析2020

    • Author(s)
      水流宏文, 石田秀和, 杉辺英世, 桂木慎一, 石井 良, 成田 淳, 上野高義, 小垣滋豊, 澤 芳樹, 大薗恵一
    • Organizer
      第56回 日本小児循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K17561
  • [Presentation] 小児心筋症における心筋線維芽細胞の生理機能ならびに病態関与の解析2020

    • Author(s)
      水流宏文, 石田秀和, 杉辺英世, 桂木慎一, 石井 良, 成田 淳, 上野高義, 小垣滋豊, 澤 芳樹, 大薗恵一
    • Organizer
      第56回 日本小児循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07789
  • [Presentation] A NEUROTROPHIC FACTOR RECEPTOR GFRA2 IDENTIFIES CARDIAC PROGENITORS AND MEDIATES CARDIOMYPCYTE DIFFERENTIATION2017

    • Author(s)
      Ishida H, Saba R, Yashiro K et al.
    • Organizer
      WESTEIN CARDIOVASCULAR DEVWLOPMENT AND REGENERATION MEETING
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19403
  • [Presentation] iPS細胞を用いた肺動脈性肺高血圧症の研究 ~現状と課題そして将来への展望~2016

    • Author(s)
      石田秀和,小垣滋豊,高橋邦彦,成田淳,那波伸敏,馬殿洋樹,桂木慎一,北畠康司,大薗恵一
    • Organizer
      第52回日本小児循環器学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-06
    • Data Source
      KAKENHI-PROJECT-16K19403
  • [Presentation] Therapeutic Application of Type B Natriuretic Peptide Receptor With a Novel Gain-of-function Mutation in the Treatment of Pulmonaly Arterial Hypertension2013

    • Author(s)
      Nawa N, Ishida H, Baden H, Takahashi K, Kogaki S, Yabushita-Okada Y, Ichimori H, Ishii R, Mihara S, Higeno R, Miura K, Ozono K.
    • Organizer
      American Heart Association, Scientiic Sessions 2013
    • Place of Presentation
      米国Dallas
    • Data Source
      KAKENHI-PROJECT-23591567
  • [Presentation] C-type natriuretic peptide (CNP)受容体(NPR-B)の機能獲得型変異体を用いた、肺動脈性高血圧症(PAH)に対する新たな治療アプローチ2013

    • Author(s)
      那波伸敏,石田秀和,馬殿洋樹,高橋邦彦,小垣滋豊,市森裕章,内川俊毅,石井良,髭野亮太,岡田陽子,三浦弘司,大薗恵一
    • Organizer
      第19回日本小児肺循環研究会
    • Place of Presentation
      東京
    • Year and Date
      2013-02-02
    • Data Source
      KAKENHI-PROJECT-23591567
  • [Presentation] Therapeutic application of type B natriuretic peptide receptor with a novel gain-of-function mutation in the treatment of pulmonary arterial hypertension2013

    • Author(s)
      Nawa N, Ishida H, Baden H, Takahashi K, Kogaki S, Yabushita-Okada Y, Ichimori H, Ishii R, Mihara S, Higeno R, Miura K, Ozono K
    • Organizer
      American Heart Association, Scientiic Sessions 2013
    • Place of Presentation
      Dallas, Texas(アメリカ合衆国)
    • Data Source
      KAKENHI-PROJECT-23591567
  • [Presentation] C-type natriuretic peptide(CNP)受容体(NPR-B)の機能獲得型変異体を用いた、肺高血圧症に対する新たな治療アプローチ(第3報)2013

    • Author(s)
      那波伸敏,石田秀和,馬殿洋樹,高橋邦彦,小垣滋豊,市森裕章,石井良,髭野亮太,藪下陽子,三浦弘司,大薗恵一
    • Organizer
      第49回日本小児循環器学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591567
  • [Presentation] C-type natriuretic peptid (CNP) 受容体 (NPR-B)の昨日獲得型変異体を用いた,肺動脈性肺高血圧症(PAH)に対する新たな治療アプローチ2012

    • Author(s)
      那波伸敏,石田秀和,高橋邦彦,小垣滋豊,市森裕章,内川俊毅,成田淳,前川周,岡田陽子,三浦弘司,大薗恵一
    • Organizer
      第18回日本小児肺循環研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591567
  • [Presentation] C-type natriuretic peptide(CNP)受容体(NPR-B)の機能獲得型変異体を用いた、肺動脈性肺高血圧症に対する新たな治療アプローチ(第2報)2012

    • Author(s)
      那波伸敏,石田秀和,高橋邦彦,小垣滋豊,市森裕章,内川俊毅,藪下陽子,三原聖子,馬殿洋樹,三浦弘司,大薗恵一
    • Organizer
      第48回日本小児循環器学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23591567
  • [Presentation] C-type natriuretic peptide (CNP)受容体(NPR-B)の機能獲得型変異体を用いた,肺動脈高血圧症(PAH)に対する新たな治療アプローチ2012

    • Author(s)
      那波伸敏,石田秀和,高橋邦彦,小垣滋豊,市森裕章,内川俊毅,成田淳,岡田陽子,三浦弘司,大薗恵一
    • Organizer
      第18回日本小児肺循環研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-04
    • Data Source
      KAKENHI-PROJECT-23591567
  • [Presentation] C-type natriuretic peptide (CNP) 受容体(NPR-B)の機能獲得型変異体を用いた、 肺動脈性肺高血圧症に対する新たな治療アプローチ 第2報2012

    • Author(s)
      那波 伸敏、石田 秀和、高橋 邦彦、小垣 滋豊、市森 裕章、内川 俊毅、藪下 陽子、三原聖子、馬殿 洋樹、三浦 弘司、大薗 恵一
    • Organizer
      第48回日本小児循環器学会総会・学術集会
    • Place of Presentation
      国立京都国際会館
    • Data Source
      KAKENHI-PROJECT-23591567
  • [Presentation] Type B Human Natriuretic Peptide Receptor with a novel gain-of-function mutation provides therapeutic potential in the treatment of pulmonary arterial hypertension2011

    • Author(s)
      Nobutoshi Nawa; hidekazu Ishida; Sigetoyo Kogaki; Toshiki Uchikawa; Yoko Okada; Jun Narita; Shu Maekawa; Hiroaki Ichimori; Koji Miura; Keiichi Ozono
    • Organizer
      American Heart Association Scientific Sessions 2011
    • Place of Presentation
      米国 オーランド
    • Data Source
      KAKENHI-PROJECT-23591567
  • [Presentation] Type B Human Natriuretic Peptide Receptor with a novel gain-of-function mutation provides therapeutic potential in the treatment of pulmonary arterial hypertension2011

    • Author(s)
      Nawa N, Ishida H, Kogaki S, Uchikawa T, Okada Y, Narita J, Maekawa S, Ichimori H, Miura K, Ozono K.
    • Organizer
      American Heart Association Scientific Sessions 2011
    • Place of Presentation
      米国オーランド
    • Year and Date
      2011-11-14
    • Data Source
      KAKENHI-PROJECT-23591567
  • [Presentation] C-type natriuretic peptide (CNP) 受容体(NPR-B)の機能獲得型変異体を用いた、 肺動脈性肺高血圧症(PAH)に対する新たな治療アプローチ

    • Author(s)
      那波 伸敏、石田 秀和、馬殿 洋樹、高橋 邦彦、小垣 滋豊、市森 裕章、内川 俊毅、石井 良、髭野 亮太、岡田 陽子、三浦 弘司、大薗 恵一
    • Organizer
      第19回日本小児肺循環研究会
    • Place of Presentation
      笹川記念館
    • Data Source
      KAKENHI-PROJECT-23591567
  • 1.  KOGAKI Shigetoyo (00311754)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 13 results
  • 2.  ISHII RYO (90794008)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 3.  TAKAHASHI Kunihiko (10610230)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 4.  ICHIMORI Hiroaki (60467553)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 5.  NAWA Nobutoshi (30617543)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  岡嶋 孝治 (70280998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  成田 淳 (70467562)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  八代 健太 (60432506)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  相澤 健一 (70436484)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  那波 伸俊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 11 results

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