FUJITA(TASAKA) Megumi 藤田めぐみ(田坂めぐみ)

… Alternative Names

FUJITA Megumi 藤田めぐみ

TASAKA Megumi 田坂めぐみ

藤田めぐみ(田坂めぐみ) フジタメグミ

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Researcher Number	50510369
Affiliation (based on the past Project Information) *help	2014: 東京医科歯科大学, 医歯学融合教育支援センター, 特任助教 2012 – 2013: 東京医科歯科大学, 医歯(薬)学総合研究科, 特任助教 2011 – 2012: 東京医科歯科大学, 大学院・医歯学総合研究科, 特任助教 2010: Tokyo Medical and Dental University, 医歯(薬)学総合研究科, その他 2009: Tokyo Medical and Dental University, 医歯学総合研究科, メディカルフェロー 2008: 東京医科歯科大学, 医学部・附属病院, 医員 2008: 東京医科歯科大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator シグナル伝達 / MHC Class 1 / インターフェロン誘導性遺伝子 / 免疫学 / ウイルス / MHC Class I / C型肝炎ウイルス / 生体発光共鳴エネルギー転移(Bioliminescence Resonance Energy ransfer) / Cardif / HCVレプリコン … More / STING / HCV-NS4B / RIG-I / インターフェロン / HCV レプリコン … More Except Principal Investigator HCV-JFH1培養系 / 小分子ライブラリー / HCV-Feoレプリコン / レプリコンシステム / C型肝炎 / HVC-JFH1培養系 / HCVレプリコン Less

Analyzing mechanism of Hepatitis C Virus eradication by Interferon-lambdaPrincipal Investigator
- Principal Investigator
  
  FUJITA(TASAKA) Megumi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
High-throughput screening of virus-and host-targeted suppressors of HCV infection
- Principal Investigator
  
  SAKAMOTO Naoya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
FRET/ BRET analysis of interaction between HCV protein and interferon signalingPrincipal Investigator
- Principal Investigator
  
  FUJITA Megumi (TASAKA Megumi)
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University
Search for new classes of HCV therapeutics by large scale screening of antiviral compounds and host cellular factors
- Principal Investigator
  
  SAKAMOTO Naoya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical and Dental University

All 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity2013
- Author(s)
  Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-kitazume A, Kiyohashi K, Murakawa M, Nishimura-Sakurai Y, Azuma S, Tasaka-Fujita M, asahina Y, Yoneyama M, Fujita T, Watanabe M
- Journal Title
  
  Hepatology
  
  Volume: 57 Issue: 1 Pages: 46-58
- DOI
  10.1002/hep.26017
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20112009, KAKENHI-PROJECT-21590831, KAKENHI-PROJECT-23390108, KAKENHI-PROJECT-23790778, KAKENHI-PROJECT-24390185, KAKENHI-PROJECT-24590957, KAKENHI-PROJECT-24590958, KAKENHI-PROJECT-24590959, KAKENHI-PROJECT-24590960, KAKENHI-PROJECT-24659359, KAKENHI-PROJECT-24890058, KAKENHI-PROJECT-25293169, KAKENHI-PROJECT-25670366, KAKENHI-PROJECT-25860522
[Journal Article] Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase2010
- Author(s)
  Karakama Y, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Nishimura-Sakurai Y, Kakinuma S, Oooka M, Azuma S, Tsuchiya K, Onogi H, Hagiwara M, Watanabe M
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 54 Pages: 3179-3186
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2010
- Author(s)
  Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
- Journal Title
  
  Virology
  
  Volume: 407 Pages: 80-90
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication.2009
- Author(s)
  Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
- Journal Title
  
  Hepatoloj Res 39
  
  Pages: 60-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein2009
- Author(s)
  Itsui Y, Sakamoto N, Megumi Tasaka- Fujita
- Journal Title
  
  Hepatology 50
  
  Pages: 1727-1737
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590831
[Journal Article] Synergistic inhibition of intracellular hepatitis C virus replication by nelfinavir and interferon-a.2009
- Author(s)
  Satoshi Toma, Tsuyoshi Yamashiro, Shingo Arakaki, Joji Shiroma, Tatsuji Maeshiro, Kenji Hibiya, Naoya Sakamoto, Fukunori Kinjo, Masao Tateyama, Jiro Fujita
- Journal Title
  
  Journal of Viral Hepatitis In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] HCV-associated gene expression and cell signaling pathway in cells with or without HCV replicon and in replicon-cured cells.2009
- Author(s)
  Nishimura-Sakurai Y, Sakamoto N, Megumi Tasaka-Fujita
- Journal Title
  
  J.Gastroentelorogy
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590831
[Journal Article] Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5Bprotein2009
- Author(s)
  Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M
- Journal Title
  
  Hepatology
  
  Volume: 50(6) Issue: 6 Pages: 1727-37
- DOI
  10.1002/hep.23195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590831
[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication2009
- Author(s)
  Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
- Journal Title
  
  Hepatology Res 39(1)
  
  Pages: 60-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication2009
- Author(s)
  Sekine-Osajima Y, Sakamoto N, Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Suda G, Mishima K, Onuki Y, Yamamoto M, Maekawa S, Enomoto N, Kanai T, Tsuchiya K, Watanabe M
- Journal Title
  
  Hepatol Res
  
  Volume: 39 Pages: 60-69
- NAID
  10025324061
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein2009
- Author(s)
  Itsui Y, Sakamoto N, Kakinuma S, Nakagawa M, Sekine-Osajima Y, Tasaka-Fujita M, Nishimura-Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S, Watanabe M
- Journal Title
  
  Hepatology
  
  Volume: 50 Pages: 1727-1737
- Data Source
  KAKENHI-PROJECT-21390226
[Journal Article] Development of plaque assays for hepatitis C virus and isolation of mutants with enhanced cytopathogenicity and replication capacity.2008
- Author(s)
  Sekine-Osajima Y, Sakamoto N (equal contribution), Nakagawa M, Itsui Y, Tasaka M, Nishimura-Sakurai Y, Chen CH, Kanai T, Tsuchiya K, Wakita T, Enomoto N, Watanabe M
- Journal Title
  
  Virology 368
  
  Pages: 71-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Potential relevance of cytoplasmic viralsensors and related regulators involving innate immunity in antiviral response2008
- Author(s)
  Asahina Y, Izumi N, Hirayama I, Tanaka T,Sato M, Yasui Y, Komatsu N, Umeda N,Hosokawa T, Ueda K, Tsuchiya K,Nakanishi H, Itakura J, Kurosaki M,Enomoto N, Tasaka M, Sakamoto N, Miyake S
- Journal Title
  
  Gastroenterology 134(5)
  
  Pages: 1396-1405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA.2008
- Author(s)
  Sakamoto N, Tanabe Y, Yokota T, Saito K, Sekine-Osajima Y, Nakagawa M, Itsui Y, Tasaka M, Sakurai Y, Chen CH, Yano M, Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
- Journal Title
  
  J Gastro Hepatol 23
  
  Pages: 1437-1447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Development of plaque assaysfor hepatitis C virus and isolation of mutantswith enhanced cytopathogenicity and replication capacity2008
- Author(s)
  Sekine-Osajima Y, Sakamoto N(equal contribution), Nakagawa M, Itsui Y, TasakaM, Nishimura-Sakurai Y, Chen CH, Kanai T,Tsuchiya K, Wakita T, Enomoto N and Watanabe M
- Journal Title
  
  Virology 371
  
  Pages: 71-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA2008
- Author(s)
  Sakamoto N, Tanabe Y, Yokota T, Saito K,Sekine-Osajima Y, Nakagawa M, Itsui Y,Tasaka M, Sakurai Y, Chen CH, Yano M,Ohkoshi S, Aoyagi Y, Maekawa S, Enomoto N, Kohara M, Watanabe M
- Journal Title
  
  J Gastro Hepatol 23(9)
  
  Pages: 1437-1447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Potential relevance of cytoplasmic viral sensors and related regulators involving innate immunity in antiviral response.2008
- Author(s)
  Asahina Y, Izumi N, Hirayama I, Tanaka T, Sato M, Yasui Y, Komatsu N, Umeda N, Hosokawa T, Ueda K, Tsuchiya K, Nakanishi H, Itakura J, Kurosaki M, Enomoto N, Tasaka M, Sakamoto N, Miyake S
- Journal Title
  
  Gastroenterology 134
  
  Pages: 1396-1405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] HCV nonstructural proteins responsible for suppression of RIG-I/Cardif-induced interferon response2007
- Author(s)
  Tasaka M, Sakamoto N(equal contribution), Itakura Y, Nakagawa M, Itusi Y,Sekine-Osajima Y, Nishimura-Sakurai Y,Chen CH, Yoneyama M, Fujita T, Wakita T,Maekawa S, Enomoto N, Watanabe M
- Journal Title
  
  J Gen Virol 88
  
  Pages: 3323-3333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Synergistic inhibition of intracellular hepatitis C virus replication by nelfinavir and interferon-α
- Author(s)
  Satoshi Toma, Tsuyoshi Yamashiro, ShingoArakaki, Joji Shiroma, Tatsuji Maeshiro, Kenji Hibiya, Naoya Sakamoto, FukunoriKinjo, Masao Tateyama, Jiro Fujita
- Journal Title
  
  Journal of Viral Hepatitis (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390196
[Journal Article] Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia
- Author(s)
  Yamashita A, Abdus K, Furuta A, Matsuda Y, Fujita O, Tani H, Fujita Y, Fujimoto Y, Ikeda M, Kato N, Sakamoto N, Maekawa S, Enomoto N, Nakakoshi M, Tsubuki M, Sekiguchi Y, Thuneda S, Akimitsu N, Noda N, Tanaka J, Moriishi K
- Journal Title
  
  Marine Drugs
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21390226
[Presentation] HCV Core領域アミノ酸70/91変異株を用いた反応機序の解析2013
- Author(s)
  藤田めぐみ，加藤孝宣，村山麻子，山田典栄，朝比奈靖浩，坂本直哉.
- Organizer
  第49回日本肝臓学会総会，
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Data Source
  KAKENHI-PROJECT-25860523
[Presentation] Substitution of amino acid 70/91 in the hepatitis C core region affects infectious virus production and cell surface expression of MHC Class I2013
- Author(s)
  Megumi Tasaka-Fujita, Nao-Sugiyama, Wonseok Kang, Asako Murayama, Naoya Sakamoto, Takaji Wakita, Eui-cheoul Shin, Takanobu Kato
- Organizer
  64th Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Walter E. Washington Convention Center(Washington D.C.)
- Data Source
  KAKENHI-PROJECT-25860523
[Presentation] HCV-NS4B blocks the RIG-I mediated IFN pathway through targeting of STING2012
- Author(s)
  Sayuri Nitta, Naoya Sakamoto, Mina Nakagawa, Sei Kakinuma, Kako Mishima, Akiko Kusano-Kitazume, Kei Kiyohashi, Miyako Murakawa, Kohei Yoshino, Megumi Tasaka-Fujita, Yasuhiro Asahina, Mamoru Watanabe
- Organizer
  19^<th> International Symposium of Hepatitis C Virus and Related Viruses
- Place of Presentation
  Venice, Italy
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCVgenotype 1b株キメラウイルスを用いた HCV core領域アミノ酸70/91変異株の解析2012
- Author(s)
  藤田めぐみ、脇田隆字、加藤孝宣
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCV-NS4B protein binds STINGand blocks the RIG-I mediated IFN pathway2012
- Author(s)
  Sayuri Nitta, Naoya Sakamoto, Mina Nakagawa, Sei Kakinuma, Akiko Kusano Kitazume, Miyako Murakawa, Megumi Tasaka-Fujita, Yasuhiro Asahina, Mamoru Watanabe
- Organizer
  10th single topic conference
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2011
- Author(s)
  Suda G, Sakamoto N, Itsui Y, Nakagawa M, Tasaka-Fujita M, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Azuma S, Kakinuma S, Tsuchiya K, Imamura M, Hiraga N, Chayama K, Watanabe M
- Organizer
  62th. Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCV-NS4B targets STING anda brogates RIG-I-mediated type-Iinterferon-dependent innate immune response2011
- Author(s)
  Sayuri Nitta, Naoya Sakamoto, Megumi Tasaka-Fujita, Kei Kiyohashi, Akiko Kusano-Kitazume, Miyako Murakawa, Kouhei Yoshino, Kako Mishima, SeiKakinuma, Mina Nakagawa, Mamoru Watanabe
- Organizer
  18th. International Meeting on Hepatitis C Virus & Related Viruses
- Place of Presentation
  Seattle, WA
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21390226
[Presentation] HCV-NS4B蛋白とRIG-I惹起性IFN産生シグナル関連蛋白との分子間相互作用の解析2011
- Author(s)
  新田沙由梨、坂本直哉、藤田めぐみ、柿沼晴、村川美也子、北詰晶子、幾世橋佳、船岡祐介、渡辺貴子、植山真由美、小野塚泉、櫻井幸、中川美奈、東正新、渡辺守
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCV-NS4B targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immune response2011
- Author(s)
  Nitta S, Sakamoto N, Tasaka-Fujita M, et al
- Organizer
  18th. International Meeting on Hepatitis C Virus & Related Viruses
- Place of Presentation
  Seattle
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCV-NS4B蛋白とIFN発現シグナル分子との分子間相互作用の解析2011
- Author(s)
  新田沙由梨、坂本直哉、藤田めぐみ、北詰晶子、幾世橋佳、船岡祐介、渡辺貴子、植山真由美、小野塚泉、東正新、中川美奈、柿沼晴、渡辺守
- Organizer
  第48回日本消化器免疫学会
- Place of Presentation
  金沢
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCV-NS4B targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immune response2011
- Author(s)
  Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-KitazumeA, KiyohashiK, Murakawa M, Yoshino K, Tasaka-Fujita M, Watanabe M
- Place of Presentation
  Seattle
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] The inhibitory effect of triterpenoid compound with or without interferonαon Hepatitis C virus infection2010
- Author(s)
  Takako Watanabe, Naoya Sakamoto, Mina Nakagawa, Yasuhiro Itsui, Yuki Nishimura-Sakurai, Megumi Tasaka-Fujita, Yuko Sekine-Osajima, and Mamoru Watanabe
- Organizer
  17th. International Meeting on Hepatitis C Virus & Related Viruses
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-21390226
[Presentation] Genotype 2型C型慢性肝炎のインターフェロン治療再燃例に対する再治療の試み2009
- Author(s)
  渡辺貴子、中川美奈、船岡祐介、植山真由美、三島果子、山本満千、小貫優子、須田剛生、櫻井幸、田坂めぐみ、筬島裕子、井津井康浩、陳正新、坂本直哉、渡辺守
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] 細胞障害性HCV-JFH1 subcloneの単離と機能解析2009
- Author(s)
  三島果子、坂本直哉、中川美奈、井津井康浩、筬島裕子、田坂めぐみ、櫻井幸、須田剛生、山本満千、植山真由美、渡辺貴子、船岡祐介、渡辺守
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] Establishment and genetic analyses of cytopathogenic HCV-JFH1 mutants by plaque-forming assay2009
- Author(s)
  Mishima K, Sakamoto N, Sekine-Osajima Y, Nakagawa M, Tasaka M, Nishimura-Sakurai Y, Itsui Y, Wakita T, Watanabe M
- Place of Presentation
  Nice
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCVコア変異株培養系を用いたインターフェロン感受性、細胞内増殖、粒子分泌能の解析2009
- Author(s)
  船岡祐介、坂本直哉、井津井康浩、須田剛生、中川美奈、田坂めぐみ、櫻井幸、小貫優子、山本満千、渡辺貴子、植山真由美、陳正新、渡辺守
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCV増殖を制御するInterferon誘導蛋白とHCV非構造蛋白の相互作用の解析2009
- Author(s)
  井津井康浩、坂本直哉、中川美奈、筬島裕子、田坂めぐみ、櫻井幸、須田剛生、三島果子、山本満千、植山真由美、渡辺貴子、船岡祐介、渡辺守
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] インターフェロン発現・作動機構とHCV蛋白2009
- Author(s)
  田坂めぐみ
- Organizer
  第13回日本肝臓学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] Genotype 2b急性肝炎由来HCVクローンの構築と増殖・粒子形成能の解析2009
- Author(s)
  須田剛生、坂本直哉、中川美奈、田坂めぐみ、櫻井幸、小貫優子、山本満千、渡辺貴子、植山真由美、船岡祐介、井津井康浩、陳正新、今村道雄、茶山一彰、渡辺守
- Organizer
  第45回日本肝臓学会総会
- Place of Presentation
  神戸
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] Establishment and genetic analyses of cytopathogenic HCV-JFH1 mutants by plaque-forming assay2009
- Author(s)
  Kako Mishima, Naoya Sakamoto, Yuko Sekine-Osajima, Mina Nakagawa, Megumi Tasaka, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Takaji Wakita, and Mamoru Watanabe
- Organizer
  16th. International Meeting on Hepatitis C Virus & Related Viruses
- Place of Presentation
  Nice, France
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21390226
[Presentation] HCV複製増殖に関連する糖脂質代謝ネットワークの網羅的解析2009
- Author(s)
  櫻井幸、坂本直哉、中川美奈、井津井康浩、田坂めぐみ、小貫優子、須田剛生、三島果子、山本満千、植山真由美、船岡祐介、渡辺貴子、陳正新、渡辺守
- Organizer
  第45回日本肝臓学会総会
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] Antiviral effects of interferon-induced proteins GBP-1 and its interactions with hepatitis C virusNS5B protein2009
- Author(s)
  Itsui Y, Sakamoto N, Nakagawa M, Osajima Y, Tasaka M, Sakurai Y, Suda G, Karakama Y, Mishima K, Yamamoto M, Watanabe T, Ueyama M, Funaoka Y, Azuma S (Chen CH), Kakinuma S, Yauchi T, Watanabe M
- Organizer
  60th. Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  Boston
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] インターフェロン発現・作動機構とHCV蛋白2009
- Author(s)
  藤田めぐみ
- Organizer
  第13回日本肝臓学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] Establishment and genetic analyses of cytopathogenic HCV-JFH1 mutants by plaque-forming assay2008
- Author(s)
  Naoya Sakamoto, Kako Mishima, YukoSekine-Osajima, Mina Nakagawa, MegumiTasaka, Yuki Nishimura-Sakurai, YasuhiroItsui, Takaji Wakita,and Mamoru Watanabe
- Organizer
  15th. International Meeting on Hepatitis C Virus & RelatedViruses
- Place of Presentation
  San Antonio, TX
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Suppression of interferon induction and response pathway by Hepatitis C virus NS4B.2008
- Author(s)
  M. Tasakal, N. Sakamoto, M. Nakagawa, Y. Itsui, Y. Nishimura-Sakurai, C. Chen, Goki Suda, Kako Mishima, Machi Yamamoto, Yuko Onuki, M. Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Establishment and genetic analyzes of cytopathogenic HCV-JFHI mutants by plaque-forming assay.2008
- Author(s)
  Naoya Sakamoto, Kako Mishima, Yuko Sekine-Osajima, Mina Nakagawa, Megumi Tasaka, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Takaji Wakita, Mamoru Watanabe
- Organizer
  15th. International Meeting on Hepatitis C Virus & Related Viruses.
- Place of Presentation
  San Antonio, TX, USA
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Establishment and genetic analyzes of cytopathogenic HCV-JFH1 mutants by plaque-forming assay.2008
- Author(s)
  Kako Mishima, Naoya Sakamoto. Yuko Sekine-Osajima, Mina Nakagawa, Megumi Tasaka, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Takaji Wakita, Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Pretreatment assessment of PEG-interferon plus ribavirin anti-HCV therapy using viral genetic profiles, NS5A-ISDR and Core mutations2008
- Author(s)
  Naoya Sakamoto, Mina Nakagawa,Cheng-Hsin Chen, Yasuhiro Itsui, Megumi Tasaka, Nobuyuki Enomoto,and Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco,CA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Establishment and genetic analyses of cytopatho genic HCV-JFH1 mutants by plaque-forming assay2008
- Author(s)
  Kako Mishima, Naoya Sakamoto, YukoSekine-Osajima, Mina Nakagawa, MegumiTasaka, Yuki Nishimura-Sakurai, YasuhiroItsui, Takaji Wakita,and Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco,CA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Suppression of interferon induction and response pathway by Hepatitis C virus NS4B2008
- Author(s)
  M. Tasaka, N. Sakamoto, M. Nakagawa, Y.Itsui, Y. Nishimura-Sakurai, C. Chen, Goki Suda, Kako Mishima, Machi Yamamoto,Yuko Onuki, M. Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco,CA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Pretreatment assessment of PEG-interferon plus ribavirin anti-HCV therapy using viral genetic profiles, NS5A-ISDR and Core mutations.2008
- Author(s)
  Naoya Sakamoto, Mina Nakagawa, Cheng-Hsin Chen, Yasuhiro Itsui, Megumi Tasaka, Nobuyuki Enomoto, Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Antiviral effects of interferon-induced proteins, GBP-1, IFI6-16 and IFI27 and their interactions with hepatitis C virus nonstructural proteins2007
- Author(s)
  Yasuhiro Itsui, Naoya Sakamoto, Mina Nakagawa, Yuko Sekine-Osajima, Megumi Tasaka,and Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, MA
- Year and Date
  2007-10-31
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Plaque-forming assays for hepatitis C virus and isolation of HCV-JFH1 mutants with enhanced cytopathogenicity and replication capacity2007
- Author(s)
  Naoya Sakamoto, Yuko Sekine-Osajima, Kako Mishima, Mina Nakagawa, Megumi Tasaka, Yuki Nishimura-Sakurai, YasuhiroItsui, Takaji Wakita,and Mamoru Watanabe
- Organizer
  Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, MA
- Year and Date
  2007-10-31
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] Development of plaque-forming assays for hepatitis C virus and isolation of mutants with enhanced cytopathogenicity and replication capacity2007
- Author(s)
  Naoya Sakamoto, Yuko Sekine-Osajima, Kako Mishima, Mina Nakagawa, Megumi Tasaka, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Takaji Wakita,and Mamoru Watanabe
- Organizer
  14th. International Meeting on Hepatitis C Virus & Related Viruses
- Place of Presentation
  Glasgow, UK
- Year and Date
  2007-09-09
- Data Source
  KAKENHI-PROJECT-19390196
[Presentation] HCV-NS4B blocks the RIG-I mediated IFN pathway through targeting of STING.
- Author(s)
  Nitta S, Sakamoto N, Tasaka-Fujita M, Asahina Y, Watanabe M et al
- Organizer
  19th International Symposium on Hepatitis C Virus and Related Viruses
- Place of Presentation
  Venice
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCV-NS4B Protein Binds STING and Blocks the RIG-I Mediated IFN Pathway.
- Author(s)
  Nitta S, Sakamoto N, Tasaka-Fujita M, Asahina Y, Watanabe M et al
- Organizer
  The 10th JSH Single Topic Conference
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] HCV genotype 1b 株キメラウイルスを用いたHCV core 領域アミノ酸 70/91 変異株の解析
- Author(s)
  藤田めぐみ、脇田隆宇、加藤孝宣
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  ホテル日航金沢（石川）
- Data Source
  KAKENHI-PROJECT-21590831
[Presentation] Gene alterations in β-catenin and p53/ cell cycle control pathway are closely associated with development and prognosis of hepatocellular carcinoma: Comprehensive analyses by next generation sequencing technology.
- Author(s)
  Fukiko Kawai-Kitahata, Yasuhiro Asahina, Syun Kaneko, Hiroko Nagata, Fumio Goto, Satoshi Otani, Miki Taniguchi, Miyako Murakawa, Sayuri Nitta, Takako Watanabe, Megumi Tasaka-Fujita, Yasuhiro Itsui, Mina Nakagawa, Sei Kakinuma, Nobuyuki Enomoto, Mamoru Watanabe
- Organizer
  Annual Meeting of American Association for the Study of Liver Diseases
- Place of Presentation
  Boston, USA
- Year and Date
  2014-11-09 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-25860523

1. CHEN Cheng-hsin (10376783)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
2. SAKAMOTO Naoya (10334418)

# of Collaborated Projects: 3 results

# of Collaborated Products: 50 results
3. WATANABE Mamoru (10175127)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
4. NAKAGAWA Mina (30401342)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
5. ITSUI Yasuhiro (20401341)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
6. KAKINUMA Sei (30372444)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. OSAJIMA Yuko (40451934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
8. ASAHINA Yasuhiro (00422692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 米山光俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUJITA(TASAKA) Megumi 藤田 めぐみ(田坂めぐみ)

FUJITA Megumi 藤田 めぐみ

TASAKA Megumi 田坂 めぐみ

藤田 めぐみ(田坂めぐみ) フジタ メグミ

Research Projects

Research Products

Co-Researchers

Analyzing mechanism of Hepatitis C Virus eradication by Interferon-lambdaPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

High-throughput screening of virus-and host-targeted suppressors of HCV infection

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

FRET/ BRET analysis of interaction between HCV protein and interferon signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search for new classes of HCV therapeutics by large scale screening of antiviral compounds and host cellular factors

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase2010

Author(s)

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[Journal Article] IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones2010

Author(s)

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Data Source

[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication.2009

Author(s)

Journal Title

Data Source

[Journal Article] Antiviral effects of the interferon-induced protein GBP-1 and its interaction with the hepatitis C virus NS5B protein2009

Author(s)

Journal Title

Data Source

[Journal Article] Synergistic inhibition of intracellular hepatitis C virus replication by nelfinavir and interferon-a.2009

Author(s)

Journal Title

Data Source

[Journal Article] HCV-associated gene expression and cell signaling pathway in cells with or without HCV replicon and in replicon-cured cells.2009

Author(s)

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Data Source

[Journal Article] Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5Bprotein2009

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two flavonoids extracts from a herb, Glycyrrhizae radix, inhibit in-vitro hepatitis C virus replication2009

Author(s)

Journal Title

Data Source

[Journal Article] Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein2009

Author(s)

Journal Title

Data Source

[Journal Article] Development of plaque assays for hepatitis C virus and isolation of mutants with enhanced cytopathogenicity and replication capacity.2008

Author(s)

FUJITA(TASAKA) Megumi 藤田めぐみ(田坂めぐみ)

FUJITA Megumi 藤田めぐみ

TASAKA Megumi 田坂めぐみ

藤田めぐみ(田坂めぐみ) フジタメグミ