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Hattori Yoshihide  服部 能英

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HATTORI Yoshihide  服部 能英

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Researcher Number 50514460
Other IDs
Affiliation (Current) 2025: 大阪公立大学, 研究推進機構 , 特任講師
Affiliation (based on the past Project Information) *help 2024: 大阪公立大学, 研究推進機構, 特任講師
2023 – 2024: 大阪公立大学, 研究推進機構, 客員研究員
2022 – 2023: 大阪公立大学, 研究推進機構, 特認講師
2022: 大阪公立大学, 研究推進機構, 特任講師
2019 – 2021: 大阪府立大学, 研究推進機構, 特認講師 … More
2017: 大阪府立大学, 研究推進機構, 講師
2015 – 2016: 大阪府立大学, 地域連携研究機構, 講師
2014: 大阪府立大学, 21世紀科学研究機構, 講師
2013: 大阪府立大学, 21世紀科学研究機構, 客員研究員 Less
Review Section/Research Field
Principal Investigator
Basic Section 37030:Chemical biology-related / Bio-related chemistry / Drug development chemistry
Except Principal Investigator
Basic Section 56010:Neurosurgery-related / Medium-sized Section 39:Agricultural and environmental biology and related fields / Basic Section 52040:Radiological sciences-related
Keywords
Principal Investigator
ホウ素クラスター / ホウ素薬剤 / BNCT / ドデカボレート / ホウ素アミノ酸 / 腫瘍集積性分子 / 蛍光標識 / セラノスティック / アルキルスルフィニウムドデカボレート / ドデカボレート含有ペプチド / ドデカボレート含有アミノ酸 / ホウ素-中性子捕捉療法 / 癌 … More
Except Principal Investigator
… More 中性子捕捉療法 / ドラッグデリバリーシステム / 悪性グリオーマ / ホウ素修飾 / アデノウイルスベクター / 品種開発 / 放射線育種 / 新規形質創生 / ホウ素中性子捕捉反応 / 育種 / ホウ素中性子捕捉療法 / RI創薬 / 術中蛍光造影 / インドシアニングリーン / 脳脊髄腫瘍 / BSH / SPECT / PET / ほう素中性子捕捉療法 / BNCT / 放射線治療計画 / 画像診断 / 生物学的効果 / 放射線治療 / 悪性神経膠腫 / がん治療 / ホウ素 / 中性子捕獲反応 / 脳腫瘍 Less
  • Research Projects

    (9 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (33 People)
  •  Development of a Novel Treatment Method Using Boron Radioisotope Compounds Targeting Brain and Spinal Cord Tumors

    • Principal Investigator
      武藤 淳
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Fujita Health University
  •  Development of efficient method for breeding plant using boron neutron capture reaction

    • Principal Investigator
      木野内 忠稔
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 39:Agricultural and environmental biology and related fields
    • Research Institution
      Kyoto University
  •  Development of neutron capture therapy using adenovirus genome-terminal protein complex for drug delivery

    • Principal Investigator
      濱 聖司
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Hiroshima University
  •  Developing of radiolabeling method and Investigation of in vivo pharmacokinetics of BSH using in BNCT

    • Principal Investigator
      金井 泰和
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Osaka Medical and Pharmaceutical University
  •  Development of Hydrophilic Boron Cluster Containing Molecular-Targeted DrugsPrincipal Investigator

    • Principal Investigator
      Hattori Yoshihide
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      Osaka Metropolitan University
      Osaka Prefecture University
  •  Establishment of multi-target neutron capture therapy with multiple boron drugs for brain tumor

    • Principal Investigator
      Kawabata Shinji
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Osaka Medical and Pharmaceutical University
  •  Clinical application of boron-conjugated adenovirus vector for neutron capture therapy

    • Principal Investigator
      Hama Seiji
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Hiroshima University
  •  Development of novel boron-pharmaceuticals for BNCT using reduced dodecaboratePrincipal Investigator

    • Principal Investigator
      Hattori Yoshihide
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bio-related chemistry
    • Research Institution
      Osaka Prefecture University
  •  Synthesis and Biological Evaluation of Ammonioundecahydro-closo-dodecaborate Containing Pharmaceuticals for BNCTPrincipal Investigator

    • Principal Investigator
      HATTORI Yoshihide
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Osaka Prefecture University

All 2023 2022 2021 2020 2018 2017 2016 2015 2014 2013

All Journal Article Presentation Patent

  • [Journal Article] Multi-Targeted Neutron Capture Therapy Combined with an 18 kDa Translocator Protein-Targeted Boron Compound Is an Effective Strategy in a Rat Brain Tumor Model2023

    • Author(s)
      Kashiwagi Hideki、Hattori Yoshihide、Kawabata Shinji、Kayama Ryo、Yoshimura Kohei、Fukuo Yusuke、Kanemitsu Takuya、Shiba Hiroyuki、Hiramatsu Ryo、Takami Toshihiro、Takata Takushi、Tanaka Hiroki、Watanabe Tsubasa、Suzuki Minoru、Hu Naonori、Miyatake Shin-Ichi、Kirihata Mitsunori、Wanibuchi Masahiko
    • Journal Title

      Cancers

      Volume: 15 Issue: 4 Pages: 1034-1034

    • DOI

      10.3390/cancers15041034

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K16698, KAKENHI-PROJECT-20H03797, KAKENHI-PROJECT-20K05753, KAKENHI-PROJECT-21K15805, KAKENHI-PROJECT-22K09270
  • [Journal Article] Dodecaborate-Encapsulated Extracellular Vesicles with Modification of Cell-Penetrating Peptides for Enhancing Macropinocytotic Cellular Uptake and Biological Activity in Boron Neutron Capture Therapy2022

    • Author(s)
      Hirase Shiori、Aoki Ayako、Hattori Yoshihide、Morimoto Kenta、Noguchi Kosuke、Fujii Ikuo、Takatani-Nakase Tomoka、Futaki Shiroh、Kirihata Mitsunori、Nakase Ikuhiko
    • Journal Title

      Molecular Pharmaceutics

      Volume: 19 Issue: 4 Pages: 1135-1145

    • DOI

      10.1021/acs.molpharmaceut.1c00882

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06676, KAKENHI-PROJECT-20K20463, KAKENHI-PROJECT-21K06567, KAKENHI-PROJECT-20K05753
  • [Journal Article] Dodecaborate Conjugates Targeting Tumor Cell Overexpressing Translocator Protein for Boron Neutron Capture Therapy2021

    • Author(s)
      Hattori Yoshihide、Ishimura Miki、Ohta Youichirou、Takenaka Hiroshi、Kawabata Shinji、Kirihata Mitsunori
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 13 Issue: 1 Pages: 50-54

    • DOI

      10.1021/acsmedchemlett.1c00377

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03797, KAKENHI-PROJECT-20K05753
  • [Journal Article] Synthesis and evaluation of dodecaboranethiol containing kojic acid (KA-BSH) as a novel agent for boron neutron capture therapy.2020

    • Author(s)
      Takeuchi F, Hattori Y, Kawabata S, Futamura G, Hiramatsu R, Wanibuchi M, Tanaka H, Masunaga S, Ono K, Miyatake S, Kirihata M.
    • Journal Title

      Cells

      Volume: 9 Issue: 6 Pages: 1551-1551

    • DOI

      10.3390/cells9061551

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08171, KAKENHI-PROJECT-20K05753, KAKENHI-PROJECT-20H03797
  • [Journal Article] Antibody-based receptor targeting using an Fc-binding peptide-dodecaborate conjugate and macropinocytosis induction for boron neutron capture therapy (BNCT)2020

    • Author(s)
      Ikuhiko Nakase, Ayako Aoki, Yuriko Sakai, Shiori Hirase, Miki Ishimura, Tomoka Takatani-Nakase, Yoshihide Hattori and Mitsunori Kirihata
    • Journal Title

      ACS Omega

      Volume: 5 Issue: 36 Pages: 22731-22738

    • DOI

      10.1021/acsomega.0c01377

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06676, KAKENHI-PROJECT-20K05753, KAKENHI-PROJECT-20K20463
  • [Journal Article] The Therapeutic Effects of Dodecaborate Containing Boronophenylalanine for Boron Neutron Capture Therapy in a Rat Brain Tumor Model2020

    • Author(s)
      Fukuo Yusuke、Hattori Yoshihide、Kawabata Shinji、Kashiwagi Hideki、Kanemitsu Takuya、Takeuchi Koji、Futamura Gen、Hiramatsu Ryo、Watanabe Tsubasa、Hu Naonori、Takata Takushi、Tanaka Hiroki、Suzuki Minoru、Miyatake Shin-Ichi、Kirihata Mitsunori、Wanibuchi Masahiko
    • Journal Title

      Biology

      Volume: 9 Issue: 12 Pages: 437-437

    • DOI

      10.3390/biology9120437

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K05753, KAKENHI-PROJECT-20H03797, KAKENHI-PROJECT-19K24055
  • [Journal Article] Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma2017

    • Author(s)
      Futamura G, Kawabata S, Nonoguchi N, Hiramatsu R, Toho T, Tanaka H, Masunaga SI, Hattori Y, Kirihata M, Ono K, Kuroiwa T, Miyatake SI
    • Journal Title

      Radiat Oncol.

      Volume: 12 Issue: 1 Pages: 26-26

    • DOI

      10.1186/s13014-017-0765-4

    • NAID

      120005997769

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462192, KAKENHI-PROJECT-26670556, KAKENHI-PROJECT-15K19982, KAKENHI-PROJECT-17K10877, KAKENHI-PROJECT-16H02612, KAKENHI-PROJECT-15K21291
  • [Journal Article] Development and Elucidation of a Novel Fluorescent Boron-Sensor for the Analysis of BoronicAcid-Containing Compounds2017

    • Author(s)
      Yoshihide Hattori, Takuya Ogaki, Miki Ishimura, Yoichiro Ohta and Mitsunori Kirihata
    • Journal Title

      Sensors

      Volume: 17 Issue: 10 Pages: 2036-2036

    • DOI

      10.3390/s17102436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02612, KAKENHI-PROJECT-15K21291
  • [Journal Article] Visualization of Boronic Acid Containing Pharmaceuticals in Live Tumor Cells Using a Fluorescent Boronic Acid Sensor2016

    • Author(s)
      Y. Hattori, M. Ishimura, Y. Ohta, H. Takenaka, M. Kirihata
    • Journal Title

      ACS Sensors

      Volume: 1 Issue: 12 Pages: 1394-1397

    • DOI

      10.1021/acssensors.6b00522

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02612, KAKENHI-PROJECT-15K21291
  • [Patent] ホウ素含有化合物2016

    • Inventor(s)
      服部能英、上原幸樹、切畑光統
    • Industrial Property Rights Holder
      服部能英、上原幸樹、切畑光統
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-148978
    • Filing Date
      2016-07-28
    • Data Source
      KAKENHI-PROJECT-15K21291
  • [Presentation] セラノスティック型BNCT用薬剤開発のためのバイファクショナルなドデカボレート誘導体の合成2023

    • Author(s)
      服部 能英
    • Organizer
      第143回日本薬学会年会
    • Data Source
      KAKENHI-PROJECT-20K05753
  • [Presentation] Synthesis and Biological Evaluation of S-Octylsulfoniododecaborate containing L-Amino Acids for Boron Neutron Capture Therapy2022

    • Author(s)
      Yoshihide Hattori
    • Organizer
      第59回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-20K05753
  • [Presentation] 蛍光型ホウ素センサーの開発とホウ素薬剤の動態解析2022

    • Author(s)
      服部 能英
    • Organizer
      第13回日本中性子捕捉療法学術大会
    • Data Source
      KAKENHI-PROJECT-20K05753
  • [Presentation] トランスロケータープロテイン(TSPO)を標的とした ドデカボレート含有化合物の BNCT用薬剤としての評価2022

    • Author(s)
      服部 能英,石村 美紀,大田 洋一郎,竹中 宏誌,上原 幸樹, 浅野 智之,切畑 光統
    • Organizer
      日本薬学会第142年会
    • Data Source
      KAKENHI-PROJECT-20K05753
  • [Presentation] 18kDa translocator protein(TSPO)標的新規ホウ素化合物を用いたF98ラット悪性神経膠腫モデルへのホウ素中性子捕捉療法の治療効果2021

    • Author(s)
      柏木秀基、服部能英、川端信司、福尾祐介、金光拓也、竹内孝治、平松 亮、高田卓志、田中浩基、渡邉 翼、鈴木 実、小野公二、宮武伸一、切畑 光統、鰐渕昌彦
    • Organizer
      第17回日本中性子捕捉療法学会学術大会
    • Data Source
      KAKENHI-PROJECT-20H03797
  • [Presentation] ラット脳腫瘍モデルへの18kDa translocator protein(TSPO)標的ホウ素中性子捕捉療法2021

    • Author(s)
      柏木 秀基, 服部 能英, 川端 信司, 福尾 祐介, 金光 拓也, 竹内 孝治, 平松 亮, 高田 卓志, 田中 浩基, 渡邉 翼, 鈴木 実, 小野 公二, 宮武 伸一, 切畑 光統, 鰐渕 昌彦
    • Organizer
      第59回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-20H03797
  • [Presentation] 悪性神経膠腫治療における18kDa translocator protein(TSPO)標的ホウ素中性子捕捉療法の有用性2021

    • Author(s)
      柏木秀基, 服部能英, 川端信司, 福尾祐介, 金光拓也, 竹内孝治, 二村元, 平松亮, 高田卓志, 田中浩基, 渡邉翼, 鈴木実, 小野公二, 宮武伸一, 切畑光統, 鰐渕昌彦
    • Organizer
      第21回日本分子脳神経外科学会
    • Data Source
      KAKENHI-PROJECT-20H03797
  • [Presentation] Effectiveness of 18kDa translocator protein (TSPO) targeting novel boron compound for boron neutron capture therapy in rat experimental brain tumor model2021

    • Author(s)
      H. Kashiwagi, Y. Hattori, S. Kawabata, Y. Fukuo, T. Kanemitsu, R. Hiramatsu, T. Takata, H. Tanaka, T. Watanabe, M. Suzuki, S. Miyatake, M. Kirihata, M. Wanibuchi
    • Organizer
      19th International congress on neutron capture therapy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03797
  • [Presentation] BNCT for F98 glioma bearing rats using a TSPO-targeted novel boron compound2021

    • Author(s)
      H. Kashiwagi, S. Kawabata, Y. Hattori, Y. Fukuo, T. Kanemitsu, K. Takeuchi, R. Hiramatsu, T. Watanabe, T. Tanaka, H. Tanaka, m. Suzuki, K. Ono, S.I. Miyatake, M. Kirihata, M. Wanibuchi
    • Organizer
      59th Annual Conference of the Particle Therapy Co-Operative Group Online Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03797
  • [Presentation] Boron neutron capture therapy targeting 18kDa translocator protein (TSPO) is a promising therapeutic method in a F98 rat glioma model2021

    • Author(s)
      Hideki Kashiwagi, Yoshihide Hattori, Shinji Kaawabata, Yusuke Fukuo, Takuya Kanemitsu, Koji Takeuchi, Ryo Hiramatsu, Takushi Takata, Hiroki Tanaka, Tsubasa Wanatabe, Minoru Suzuki, Koji Ono, Shinichi Miyatake, Mitsunori Kirihata, Masahiko Wanibuchi
    • Organizer
      2021 JCA-AACR Precision Cancer Medicine International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03797
  • [Presentation] 18kDa mitochondrial translocator proteinを標的とした悪性神経膠腫へのBNCTの可能性2020

    • Author(s)
      柏木秀基、川端信司、福尾祐介、金光拓也、竹内孝治、二村元、平松亮、服部能英、切畑光統、鰐渕昌彦
    • Organizer
      第2回生体量子捕獲反応研究会
    • Data Source
      KAKENHI-PROJECT-20H03797
  • [Presentation] Development of Dodecaborate Containing Amino Acid Derivatives for BNCT2020

    • Author(s)
      Yoshihide Hattori
    • Organizer
      2020 Taiwan-Japan BNCT International Conference
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05753
  • [Presentation] Translocator proteinを標的とする新規ホウ素化合物を用いたラット脳腫瘍モデルへのホウ素中性子捕捉療法2020

    • Author(s)
      柏木秀基、川端信司、福尾祐介、金光拓也、竹内孝治、平松亮、宮武伸一、服部能英、切畑光統、高田卓志、田中浩基、鈴木実、小野公二、鰐渕昌彦
    • Organizer
      日本脳神経外科学会第79回学術総会
    • Data Source
      KAKENHI-PROJECT-20H03797
  • [Presentation] アルキルスルホニオドデカボレート含有アミノ酸のBNCT用ホウ素キャリアーとしての評価2018

    • Author(s)
      服部能英
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-15K21291
  • [Presentation] Detection of Boron Pharmaceuticals in Biological Environment2017

    • Author(s)
      服部能英
    • Organizer
      2017ホウ素栄養研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K21291
  • [Presentation] ドデカボレート含有型BPAのホウ素キャリアーとしての評価2017

    • Author(s)
      服部能英
    • Organizer
      第14回日本中性子捕捉療法学会学術大会
    • Data Source
      KAKENHI-PROJECT-15K21291
  • [Presentation] Synthesis and Biological Evaluation of Medium-Chain Alkyl Sulfoniododecaborate Containing p-Boronophenylalanine2017

    • Author(s)
      服部能英
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-15K21291
  • [Presentation] ホウ素‐中性子捕捉療法に用いる次世代型ホウ素薬剤の開発2016

    • Author(s)
      服部 能英
    • Organizer
      第18回癌治療増感シンポジウム
    • Place of Presentation
      奈良県文化会館(奈良県奈良市)
    • Year and Date
      2016-02-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-25870625
  • [Presentation] DEVELOPMENT OF REDUCED THIODODECABORATE CONTAINING AMINO ACIDS AND PEPTIDES FOR BORON NEUTRON CAPTURE THERAPY2016

    • Author(s)
      服部能英、石村美紀、大田洋一郎、竹中宏志、上原幸樹、浅野智之、切畑光統
    • Organizer
      第53回ペプチド討論会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-15K21291
  • [Presentation] 分子プローブを用いたホウ素薬剤の分布解析2016

    • Author(s)
      服部能英
    • Organizer
      第10回光生体超分子化学セミナー
    • Place of Presentation
      近畿大学
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K21291
  • [Presentation] ドデカボレート含有アミノ酸類のホウ素キャリアーとしての評価2016

    • Author(s)
      服部 能英
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2016-09-04
    • Data Source
      KAKENHI-PROJECT-15K21291
  • [Presentation] ドデカボレートをホウ素源とする有機低分子型ホウ素キャリアーの開発2016

    • Author(s)
      服部能英、石村美紀、大田洋一郎、竹中宏志、上原幸樹、浅野智之、切畑光統
    • Organizer
      第13回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      東京大学
    • Year and Date
      2016-08-06
    • Data Source
      KAKENHI-PROJECT-15K21291
  • [Presentation] ドデカボレート含有アミノ酸類のホウ素キャリアーとしての評価2015

    • Author(s)
      服部 能英
    • Organizer
      第12回日本中性子捕捉療法学会学術大会
    • Place of Presentation
      神戸学院大学(兵庫県神戸市)
    • Year and Date
      2015-09-04
    • Data Source
      KAKENHI-PROJECT-25870625
  • [Presentation] アンモニオドデカボレートのアシル化反応を利用したドデカボレート含有アミノ酸誘導体の合成と評価2014

    • Author(s)
      服部 能英
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本県熊本市
    • Data Source
      KAKENHI-PROJECT-25870625
  • [Presentation] Synthesis and Biological Evaluation of Ammonioundecahydro-closo-dodecaborate(1–) Containing Amino Acids Derivatives for BNCT2013

    • Author(s)
      服部 能英
    • Organizer
      第30回ペプチドセミナー
    • Place of Presentation
      兵庫県神戸市
    • Data Source
      KAKENHI-PROJECT-25870625
  • [Presentation] ドデカボレート含有アミノ酸のin vitroにおける生理活性評価2013

    • Author(s)
      服部 能英
    • Organizer
      第10回日本中性子捕捉療法学術大会
    • Place of Presentation
      岡山県岡山市
    • Data Source
      KAKENHI-PROJECT-25870625
  • [Presentation] Synthesis and Biological Evaluation of Ammonioundecahydro-closo-dodecaborate(1–) Containing Amino Acids Derivatives for BNCT2013

    • Author(s)
      服部 能英
    • Organizer
      4th Asia-Pacific International Peptide symposium
    • Place of Presentation
      大阪府吹田市
    • Data Source
      KAKENHI-PROJECT-25870625
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