Nishihara Tasuku 西原佑

Researcher Number	50568912
Other IDs
Affiliation (Current)	2025: 愛媛大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2025: 愛媛大学, 医学系研究科, 教授 2021 – 2024: 愛媛大学, 医学系研究科, 准教授 2023: 愛媛大学, 医学部附属病院, 講師 2017 – 2021: 愛媛大学, 医学部附属病院, 講師 2015 – 2017: 愛媛大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Anesthesiology / Basic Section 55050:Anesthesiology-related / Basic Section 55060:Emergency medicine-related Except Principal Investigator Basic Section 55050:Anesthesiology-related / Basic Section 52030:Psychiatry-related / Emergency medicine / Anesthesiology
Keywords	Principal Investigator マイクログリア / ミクログリア / ミエリン / 神経保護 / ドパミン / 起炎症性サイトカイン / ドパミン受容体 / 神経炎症 / 敗血症関連脳症 / せん妄 … More / 敗血症 / 神経前駆細胞 / 神経保護因子 / 神経細胞 / IGF-2 / 神経栄養因子 / 遅発性脳症 / 一酸化炭素中毒 / 神経保護性 / 脊髄前角 / 活性化マイクログリア / 末梢神経傷害 / シナプティックストリッピング / マイクログリア活性化 … More Except Principal Investigator ミクログリア / 間歇型一酸化炭素中毒 / アセチルコリン / 神経幹細胞 / 脳・神経 / マイクログリア / ミトコンドリア / 交感神経 / 術後感染 / 免疫麻痺 / B細胞 / 敗血症 / 鎮痛薬 / Macrophage / Microglia / Delirium / Dopamine receptor / 全RNA解析 / 神経栄養因子 / 成体海馬神経細胞新生 / 免疫学 / 細胞・組織 / 遺伝子 / 認知機能低下 / 海馬神経細胞新生 / アストロサイト / ミエリン / 神経細胞 / 一酸化炭素中毒 / アポトーシス / 遅発性脳症 / 神経保護因子 / 一酸化炭素 / delayed encephalopathy / carbon monoxide / neurotrophic factor / microglia / 呼気終末陽圧 / Pulse Pressure Variation / Stroke Volume Variation / 過剰輸液 / 過剰輸血 / 一回心拍出量変動 / 輸液反応性 Less

間歇型一酸化炭素中毒の病態解明および治療方法の究明
- Principal Investigator
  
  越智紳一郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Ehime University
ドーパミン受容体に関連させた敗血症関連脳症の病態生理解明と新規治療法の開発
- Principal Investigator
  
  チョードリエマムッサレヒン
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Ehime University
交感神経活性化が引き起こすB細胞減少による術後感染メカニズムの解明
- Principal Investigator
  
  阿部尚紀
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Ehime University
マイクログリアに発現するドパミンD1受容体を介した新規せん妄治療戦略の開発Principal Investigator
- Principal Investigator
  
  西原佑
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Ehime University
間歇型一酸化炭素中毒の病態解明及び治療の究明
- Principal Investigator
  
  越智紳一郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Ehime University
The effects of neurotrophic factor for carbon monoxide poisoning–induced delayed encephalopathyPrincipal Investigator
- Principal Investigator
  
  Nishihara Tasuku
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Ehime University
呼気終末陽圧負荷による輸液過剰の検出アルゴリズムの開発
- Principal Investigator
  
  池宗啓蔵
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Ehime University
Distinctive pathophysiological features of Carbon monoxide poisoning-induced delayed encephalopathy compared with hypoxemia-induced brain damage
- Principal Investigator
  
  Yorozuya Toshihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Ehime University
Activation of microglia after sciatic nerve injuryPrincipal Investigator
- Principal Investigator
  
  Nishihara Tasuku
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Ehime University
The pathogenesis study in rats with delayed carbon monoxide encephalopathy
- Principal Investigator
  
  Ochi Shinichiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Ehime University
Therapeutic effects to neuropathic pain by inhibition of STAT1 phosphorizationPrincipal Investigator
- Principal Investigator
  
  Nishihara Tasuku
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Ehime University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Anti-inflammatory effects of dopamine on microglia and a D1 receptor agonist ameliorates neuroinflammation of the brain in a rat delirium model2023
- Author(s)
  Nishikawa Yuki、Choudhury Mohammed E.、Mikami Kanta、Matsuura Taisei、Kubo Madoka、Nagai Masahiro、Yamagishi Satoru、Doi Tomomi、Hisai Manami、Yamamoto Haruto、Yajima Chisato、Nishihara Tasuku、Abe Naoki、Yano Hajime、Yorozuya Toshihiro、Tanaka Junya
- Journal Title
  
  Neurochemistry International
  
  Volume: 163 Pages: 105479-105479
- DOI
  10.1016/j.neuint.2023.105479
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06856, KAKENHI-PROJECT-20K21499, KAKENHI-PROJECT-23K21369, KAKENHI-PROJECT-23K08383
[Journal Article] Neural precursor cells are decreased in the hippocampus of the delayed carbon monoxide encephalopathy rat model2021
- Author(s)
  Ochi S, Sekiya K, Abe N, Funahashi Y, Kumon H, Yoshino Y, Nishihara T, Boku S, Iga J, Ueno S
- Journal Title
  
  Scientific Reports
  
  Volume: 18 Issue: 1 Pages: 6244-6244
- DOI
  10.1038/s41598-021-85860-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09436, KAKENHI-PROJECT-18K07564
[Journal Article] Chronic constriction injury of the sciatic nerve in rats causes different activation modes of microglia between the anterior and posterior horns of the spinal cord2020
- Author(s)
  Nishihara T, Tanaka J, Sekiya K, Nishikawa Y, Abe N, Hamada T, Kitamura S, Ikemune K, Ochi S, Choudhury ME, Yano H, Yorozuya T
- Journal Title
  
  Neurochemistry International
  
  Volume: 134 Pages: 104672-104672
- DOI
  10.1016/j.neuint.2020.104672
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09436, KAKENHI-PROJECT-17K11576, KAKENHI-PROJECT-20K06856
[Journal Article] Microglia and Macrophages in the Pathological Central and Peripheral Nervous Systems2020
- Author(s)
  Abe N, Nishihara T, Yorozuya T, Tanaka J
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 9 Pages: 2132-2132
- DOI
  10.3390/cells9092132
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09436, KAKENHI-PROJECT-20K21465
[Journal Article] A Case Report of Thrombotic Complete Obstruction of the Ascending Aorta as a Complication of Venoarterial Extracorporeal Membrane Oxygenation Support: Steps to Prevent Thrombosis2020
- Author(s)
  Nishihara T*, Kudamatsu N, Hamada T, Nakata Y, Yamamoto W, Nandate H, Namiguchi K, Nishimura T, Izutani H, Yorozuya T
- Journal Title
  
  Journal of Cardiothoracic Surgery
  
  Volume: 23 Issue: 1 Pages: 185-185
- DOI
  10.1186/s13019-020-01239-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09436
[Journal Article] Hemolytic reaction in the washed salvaged blood of a patient with paroxysmal nocturnal hemoglobinuria2019
- Author(s)
  Kawamoto Y, Nishihara T, Watanabe A, Nakanishi K, Hamada T, Konishi A, Abe N, Kitamura S, Ikemune K, Toda Y, Yorozuya T
- Journal Title
  
  BMC Anesthesiology
  
  Volume: 19(1) Issue: 1 Pages: 83-83
- DOI
  10.1186/s12871-019-0752-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09436, KAKENHI-PROJECT-17K11576
[Journal Article] Carbon monoxide poisoning-induced delayed encephalopathy accompanies decreased microglial cell numbers: Distinctive pathophysiological features from hypoxemia-induced brain damage2019
- Author(s)
  Sekiya K, Nishihara T, Abe N, Konishi A, Nandate H, Hamada T, Ikemune K, Takasaki Y, Tanaka J, Asano M, Yorozuya T
- Journal Title
  
  Brain Research
  
  Volume: 1710 Pages: 22-32
- DOI
  10.1016/j.brainres.2018.12.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16736, KAKENHI-PROJECT-19K09436, KAKENHI-PROJECT-17K11576
[Journal Article] Comparison of the detrimental features of microglia and infiltrated macrophages in traumatic brain injury: a study using a hypnotic bromovalerylurea2018
- Author(s)
  Abe N, Choudhury ME, Watanabe M, Kawasaki S, Nishihara T, Yano H, Matsumoto S, Kunieda T, Kumon Y, Yorozuya T, Tanaka J
- Journal Title
  
  Glia
  
  Volume: 66(10) Issue: 10 Pages: 2158-2173
- DOI
  10.1002/glia.23469
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11576, KAKENHI-PROJECT-18K16587, KAKENHI-PROJECT-17K16650, KAKENHI-PROJECT-17K16736
[Journal Article] Development of a postoperative occlusive thrombus at the site of an implanted inferior vena cava filter: A case report.2018
- Author(s)
  Ayako Kukida, Yasushi Takasaki, Mio Nakata, Tasuku Nishihara, Sakiko Kitamura, Sonoko Fujii, Yuji Watanabe, Toshihiro Yorozuya
- Journal Title
  
  Medicine (Baltimore)
  
  Volume: 97(3) Issue: 3 Pages: e9675-e9675
- DOI
  10.1097/md.0000000000009675
- Data Source
  KAKENHI-PROJECT-17K16736
[Journal Article] Effect of dexmedetomidine on intraocular pressure in patients undergoing robot-assisted laparoscopic radical prostatectomy under total intravenous anesthesia: A randomized, double blinded placebo controlled clinical trial2018
- Author(s)
  Kitamura S, Takechi K, Nishihara T, Konishi A, Takasaki Y, Yorozuya T
- Journal Title
  
  Journal of Clinical Anesthesia
  
  Volume: 49 Pages: 30-35
- DOI
  10.1016/j.jclinane.2018.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16736
[Journal Article] Effect of dexmedetomidine on intraocular pressure in patients undergoing robot-assisted laparoscopic radical prostatectomy under total intravenous anesthesia: A randomized, double blinded placebo controlled clinical trial2018
- Author(s)
  Kitamura S, Takechi K, Nishihara T, Konishi A, Takasaki Y, Yorozuya T
- Journal Title
  
  Journal of Clinical Anesthesia
  
  Volume: 49 Pages: 30-35
- DOI
  10.1016/j.jclinane.2018.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11576
[Journal Article] Effects of hypnotic bromovalerylurea on microglial BV2 cells2017
- Author(s)
  Shun Kawasaki, Naoki Abe, Fumito Ohtake, Afsana Islam, Mohammed Emamussalehin Choudhury, et al.
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 134 Issue: 2 Pages: 116-123
- DOI
  10.1016/j.jphs.2017.05.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16650, KAKENHI-PROJECT-17K16736, KAKENHI-PROJECT-15K10809
[Journal Article] Perioperative management of a patient with Coffin-Lowry syndrome complicated by severe obesity: A case report and literature review.2017
- Author(s)
  Mikako Hirakawa, Tasuku Nishihara, Kazuo Nakanishi, Sakiko Kitamura, Sonoko Fujii, Keizo Ikemune, Kentaro Dote, Yasushi Takasaki, Toshihiro Yorozuya
- Journal Title
  
  Medicine (Baltimore)
  
  Volume: 96(49) Issue: 49 Pages: e9026-e9026
- DOI
  10.1097/md.0000000000009026
- Data Source
  KAKENHI-PROJECT-17K16736
[Journal Article] Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain.2017
- Author(s)
  Hong S, Remacle AG, Shiryaev SA, Choi W, Hullugundi SK, Dolkas J, Angert M, Nishihara T, Yaksh TL, Strongin AY, Shubayev VI.
- Journal Title
  
  Brain, Behavior, and Immunity.
  
  Volume: 60 Pages: 282-292
- DOI
  10.1016/j.bbi.2016.11.003
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20047
[Presentation] 一酸化炭素中毒後遅発性脳症に対する神経栄養因子による予防効果の検討2022
- Author(s)
  西原佑、関谷慶介、阿部尚紀、濱田泰輔、萬家俊博
- Organizer
  日本麻酔科学会第69回学術集会
- Data Source
  KAKENHI-PROJECT-19K09436
[Presentation] 末梢神経傷害時の脊髄前角と後角における活性化マイクログリアの貪食ターゲットの違い2019
- Author(s)
  西原　佑、萬家　俊博
- Organizer
  日本神経麻酔集中治療学会
- Data Source
  KAKENHI-PROJECT-17K16736
[Presentation] The comparison of microglial phagocytosis between carbon monoxide poisoning and hypoxemic hypoxia2018
- Author(s)
  Keisuke Sekiya, Tasuku Nishihara, Naoki Abe, Toshihiro Yorozuya
- Organizer
  Society for Neuroscience Annual Meeting 2018
- Data Source
  KAKENHI-PROJECT-17K11576
[Presentation] Microglial activation in spinal anterior horn after peripheral nerve injury: is the activation detrimental or neuroprotective?2018
- Author(s)
  Tasuku Nishihara, Junya Tanaka, Toshihiro Yorozuya
- Organizer
  Society for Neuroscience Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16736

1. Ochi Shinichiro (40568911)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 阿部尚紀 (10512155)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. Yorozuya Toshihiro (10230848)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. チョードリエマムッサレヒン (90726803)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 田中潤也 (70217040)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Ueno Shuichi (80232768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Iga Jun-ichi (70363140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 池宗啓蔵 (50549219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 南立秀幸 (70568831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 朴秀賢 (60455665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. チョードリエマムッセレヒン

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Nishihara Tasuku 西原 佑

Research Projects

Research Products

Co-Researchers

間歇型一酸化炭素中毒の病態解明および治療方法の究明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ドーパミン受容体に関連させた敗血症関連脳症の病態生理解明と新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

交感神経活性化が引き起こすB細胞減少による術後感染メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マイクログリアに発現するドパミンD1受容体を介した新規せん妄治療戦略の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

間歇型一酸化炭素中毒の病態解明及び治療の究明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effects of neurotrophic factor for carbon monoxide poisoning&#8211;induced delayed encephalopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

呼気終末陽圧負荷による輸液過剰の検出アルゴリズムの開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Distinctive pathophysiological features of Carbon monoxide poisoning-induced delayed encephalopathy compared with hypoxemia-induced brain damage

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Activation of microglia after sciatic nerve injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The pathogenesis study in rats with delayed carbon monoxide encephalopathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic effects to neuropathic pain by inhibition of STAT1 phosphorizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Anti-inflammatory effects of dopamine on microglia and a D1 receptor agonist ameliorates neuroinflammation of the brain in a rat delirium model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neural precursor cells are decreased in the hippocampus of the delayed carbon monoxide encephalopathy rat model2021

Author(s)

Journal Title

DOI

Data Source

Nishihara Tasuku 西原佑

The effects of neurotrophic factor for carbon monoxide poisoning–induced delayed encephalopathyPrincipal Investigator