Ishihara Naoe 石原直恵 (琴村直恵)

… Alternative Names

琴村直恵

石原直恵(琴村直恵) イシハラナオエ

ISHIHARA Naoe 石原直恵

琴村直恵

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Researcher Number	50571791
Affiliation (Current)	2025: 藤田医科大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help	2018 – 2022: 藤田医科大学, 医学部, 研究員 2014 – 2017: 藤田保健衛生大学, 医学部, 研究員 2010 – 2012: 藤田保健衛生大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology / Genetics/Genome dynamics Except Principal Investigator Genome biology
Keywords	Principal Investigator クロマチン / アロマターゼ / 遺伝子発現 / 分化 / 栄養膜細胞 / 胎盤 / 転写調節因子 / ヒストン修飾 / 細胞分化 / 生殖医学 / 転写調節 / プロモーター / ヒストン … More Except Principal Investigator … More ヒストン修飾 / セントロメア / 次世代シーケンサー / CYP19 / プロモーター / 転写 / SEVENS法 / ヌクレオソーム / クロマチン Less

The study of human trophoblast differentiation: epigenetic transcription regulation of aromatase genePrincipal Investigator
- Principal Investigator
  
  Ishihara Naoe
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Fujita Health University
The study of human trophoblast differentiationPrincipal Investigator
- Principal Investigator
  
  Ishihara Naoe
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Fujita Health University
Chromatin structure as a determinant of transcriptional activity
- Principal Investigator
  
  Ishihara Satoru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genome biology
- Research Institution
  Fujita Health University
Spatiotemporal alteration of chromatin structure at promoter regionsPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Naoe
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Fujita Health University

All 2021 2019 2018 2017 2016 2015 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Transcriptional regulation of CYP19 by cohesin-mediated chromosome tethering in human granulosa cells2021
- Author(s)
  Kotomura Naoe、Harada Nobuhiro、Shimono Yohei、Ishihara Satoru
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 27 Pages: 101086-101086
- DOI
  10.1016/j.bbrep.2021.101086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09632
[Journal Article] Local states of chromatin compaction at transcription start sites control transcription levels2021
- Author(s)
  Ishihara Satoru、Sasagawa Yohei、Kameda Takeru、Yamashita Hayato、Umeda Mana、Kotomura Naoe、Abe Masayuki、Shimono Yohei、Nikaido Itoshi
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 49 Issue: 14 Pages: 8007-8023
- DOI
  10.1093/nar/gkab587
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-19H05789, KAKENHI-PROJECT-20H03223, KAKENHI-PROJECT-20K09632, KAKENHI-PROJECT-21K18876
[Journal Article] Ligation-mediated PCR with a back-to-back adapter reduces amplification bias resulting from variations in GC content2017
- Author(s)
  Satoru Ishihara, Naoe Kotomura, Naoki Yamamoto, Hiroshi Ochiai
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 531 Pages: 37-44
- DOI
  10.1016/j.ab.2017.05.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11118
[Journal Article] The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene2015
- Author(s)
  Kotomura, N.,Harada, N., & Ishihara, S.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 5 Pages: e0128282-e0128282
- DOI
  10.1371/journal.pone.0128282
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461398, KAKENHI-PROJECT-26430188
[Journal Article] The roleof IL-15 in activating STAT5 and fine- tuning IL-17A production in CD4 T lymphocytes2012
- Author(s)
  Pandiyan,P., Yang,XP., Saravanamuthu, SS., Zheng,L., Ishihara,S., O'Shea, JJ., and Lenardo, MJ
- Journal Title
  
  J. Immunol
  
  Volume: 189 Issue: 9 Pages: 4237-4246
- DOI
  10.4049/jimmunol.1201476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510219, KAKENHI-PROJECT-22570006
[Journal Article] Two-step binding of transcription factors causes sequential chromatin structural changes at the activated IL-2 promoter2011
- Author(s)
  Satoru Ishihara
- Journal Title
  
  The Journal of Immunology
  
  Volume: 187 Pages: 3292-3299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570006
[Journal Article] Two-step binding of transcription factors causes sequential chromatin structural changes at the activated IL-2 promoter2011
- Author(s)
  Ishihara, S. and Schwartz, RH
- Journal Title
  
  J. Immunol
  
  Volume: 187 Issue: 6 Pages: 3292-3299
- DOI
  10.4049/jimmunol.1003173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510219, KAKENHI-PROJECT-22570006
[Journal Article] A new fractionation assay,based on the size of formaldehyde crosslinked, mildly sheared chroma-tin, delineates the chromatin struc-ture at promoter regions2010
- Author(s)
  Ishihara, S., Varma, R., and Schwartz,RH
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38 Issue: 11 Pages: e124-e124
- DOI
  10.1093/nar/gkq203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22510219, KAKENHI-PROJECT-22570006
[Presentation] 転写開始点でのクロマチンの部分凝集は遺伝子の転写量と負の相関を示す2019
- Author(s)
  石原悟、笹川洋平、亀田健、山下隼人、琴村直恵、阿部真之、下野洋平、二階堂愛
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K11118
[Presentation] ヌクレオソームの凝集度の違いでクロマチンを分画する2018
- Author(s)
  石原悟、笹川洋平、琴村直恵、山下隼人、二階堂愛
- Organizer
  2018年度日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K11118
[Presentation] 卵巣顆粒膜細胞でのCYP19遺伝子は２カ所のオープンクロマチン領域によって転写調節される2017
- Author(s)
  琴村直恵、原田信広、石原悟
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K11118
[Presentation] An LM-PCR method capable of evenly amplifying DNA fragments with various GC content2016
- Author(s)
  Ishihara, S., Kotomura, N., Yamamoto, N., Ochiai, H.
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26430188
[Presentation] SEVENS assay: a chromatin fractionation based on the local density of nucleosomes2015
- Author(s)
  石原悟
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  金沢大学角間キャンパス
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-26430188
[Presentation] CYP19遺伝子のプロモーター選択機構:密なクロマチン構造でプロモーターを選択的に抑制する2012
- Author(s)
  石原悟,琴村直恵,原田信広
- Organizer
  第6回日本エピジェネティクス研究会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] CYP19遺伝子のプロモーター選択機構：密なクロマチン構造でプロモーターを選択的に抑制する2012
- Author(s)
  石原悟、琴村直恵、原田信広
- Organizer
  第6回日本エピジェネティクス研究会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] The chromatin structure responsible for the degree of the promoter activity2012
- Author(s)
  琴村直恵,原田信広,石原悟
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] The chromatin structure responsible for the degree of the promoter activity.2012
- Author(s)
  Kotomura, N., Harada, N., Ishihara, S.
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] ヒストンH3K27のトリメチル化によるアロマターゼ遺伝子プロモーターの選択的不活性化2011
- Author(s)
  石原悟
- Organizer
  第19回日本ステロイドホルモン学会学術集会
- Place of Presentation
  福岡大学病院メディカルホール(福岡県福岡市)
- Year and Date
  2011-11-26
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] ヒストンH3K27のトリメチル化によるアロマターゼ遺伝子プロモーターの選択的不活性化2011
- Author(s)
  石原悟,琴村直恵,西芳寛,野村政壽,柳瀬敏彦,原田信広
- Organizer
  第19回日本ステロイドホルモン学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2011-11-26
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] Thecontribution of histone modifica-tions to alternative promoter usageof the human CYP19 gene.2011
- Author(s)
  琴村直恵,原田信広,石原悟
- Organizer
  第34回日本分子生物学会年会.
- Place of Presentation
  横浜.
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] Condensed Chromatin Marked by K27-Trimethylated Histone H3 Determines Alternative Promoter Usage of the CYP19 Gene2011
- Author(s)
  石原悟
- Organizer
  第5回日本エピジェネティクス研究会年会
- Place of Presentation
  KKRホテル熊本(熊本県熊本市)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] The contribution of histone modifications to alternative promoter usage of the human CYP19 gene2011
- Author(s)
  石原悟
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] Condensed chromatin marked by K27-trimethylated histone H3 determinesalternative promoter usage of the CYP19 gene2011
- Author(s)
  Kotomura,N.,Harada,N.,Ishihara,S
- Organizer
  CDB Symposium"Epigene- tic landscape in development and dis-ease
- Place of Presentation
  Kobe,JAPAN
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] Condensed Chromatin Marked by K27-Trimethy-lated Histone H3 Determines Alterna-tive Promoter Usage of the CYP19 Gene2011
- Author(s)
  石原悟,琴村直恵,原田信広
- Organizer
  第5回日本エピジェネティクス研究会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] Sequentialrearrangement and eviction of nucleo-somes allow interleukin-2 transcrip-tion following T cell activation.2010
- Author(s)
  Ishihara,S.,Schwartz,RH
- Organizer
  TheNIBB Conference " DYNAMICGENOME "
- Place of Presentation
  Okazaki, JAPAN
- Year and Date
  2010-10-16
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] アロマターゼ遺伝子CYP19のプロモーター選択に関するエピジェネティクス解析2010
- Author(s)
  石原悟
- Organizer
  第18回日本ステロイドホルモン学会
- Place of Presentation
  WINC AICHI(愛知県名古屋市)
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-22570006
[Presentation] SEVENS 法：closed クロマチンとopen クロマチンを生化学的に分離分画する新たな方法
- Author(s)
  石原悟
- Organizer
  定量生物学の会　第７回年会
- Place of Presentation
  九州大学筑紫キャンパス
- Year and Date
  2015-01-11 – 2015-01-12
- Data Source
  KAKENHI-PROJECT-26430188

1. ISHIHARA Satoru (00300723)

# of Collaborated Projects: 4 results

# of Collaborated Products: 25 results
2. 原田信広 (00189705)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. NIKAIDO ITOSHI (00383290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SASAGAWA YOHEI (10404344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 下野洋平 (90594630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. ABE Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 山下隼人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishihara Naoe 石原 直恵 (琴村 直恵)

琴村直恵

石原 直恵(琴村直恵) イシハラ ナオエ

ISHIHARA Naoe 石原 直恵

琴村 直恵

Research Projects

Research Products

Co-Researchers

The study of human trophoblast differentiation: epigenetic transcription regulation of aromatase genePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study of human trophoblast differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chromatin structure as a determinant of transcriptional activity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Spatiotemporal alteration of chromatin structure at promoter regionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transcriptional regulation of CYP19 by cohesin-mediated chromosome tethering in human granulosa cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Local states of chromatin compaction at transcription start sites control transcription levels2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ligation-mediated PCR with a back-to-back adapter reduces amplification bias resulting from variations in GC content2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The roleof IL-15 in activating STAT5 and fine- tuning IL-17A production in CD4 T lymphocytes2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two-step binding of transcription factors causes sequential chromatin structural changes at the activated IL-2 promoter2011

Author(s)

Journal Title

Data Source

[Journal Article] Two-step binding of transcription factors causes sequential chromatin structural changes at the activated IL-2 promoter2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A new fractionation assay,based on the size of formaldehyde crosslinked, mildly sheared chroma-tin, delineates the chromatin struc-ture at promoter regions2010

Author(s)

Journal Title

DOI

Data Source

[Presentation] 転写開始点でのクロマチンの部分凝集は遺伝子の転写量と負の相関を示す2019

Author(s)

Organizer

Data Source

[Presentation] ヌクレオソームの凝集度の違いでクロマチンを分画する2018

Author(s)

Organizer

Data Source

[Presentation] 卵巣顆粒膜細胞でのCYP19遺伝子は２カ所のオープンクロマチン領域によって転写調節される2017

Ishihara Naoe 石原直恵 (琴村直恵)

石原直恵(琴村直恵) イシハラナオエ

ISHIHARA Naoe 石原直恵

琴村直恵