Negishi Yasuyuki 根岸靖幸

… Alternative Names

NEGISHI Yasuyuki 根岸靖幸

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Researcher Number	50644580
Other IDs
Affiliation (Current)	2025: 日本医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 日本医科大学, 医学部, 准教授 2017 – 2019: 日本医科大学, 医学部, 講師 2014 – 2017: 日本医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 56020:Orthopedics-related / Basic Section 59040:Nutrition science and health science-related / Embryonic/Neonatal medicine / Obstetrics and gynecology
Keywords	Principal Investigator 自然免疫 / 早産 / プロゲステロン / 樹状細胞 / 無菌性炎症 / 流産 / 炎症 / 生殖免疫 / アラーミン / HMGB1 … More / NKT細胞 / マクロファージ / 免疫学 / 産婦人科学 / 生殖免疫学 / α-galactosylceramide / iNKT細胞 … More Except Principal Investigator 自然免疫 / 樹状細胞 / 無菌性炎症 / NKT細胞 / アラーミン / HMGB1 / 早産 / 胎盤 / サイトカイン / 骨粗鬆症 / 産科学 / 子宮内膜症 / マクロファージ / sterile inflammation / 妊娠 / 生殖免疫 / 骨代謝 / Class Ⅲアルコール脱水素酵素 / 慢性アルコール摂取 / 続発性骨粗鬆症 / 骨吸収 / 骨形成 / ADH3 / アルコール / 内在性ウイルス / マルチオミックス解析 / エクソソーム / 胎盤形成不全 / 妊娠高血圧症候群 / 細胞外ナノ粒子 / HMGb1 / パターン認識受容体 / 卵巣子宮内膜症性嚢胞 / 骨免疫 / OCH / 破骨細胞 / 閉経後骨粗鬆症 / fetal growth restriction / 亜鉛 / 胎児発育不全 / アルコール脂肪肝 / 突然死 / 脂肪肝 / アルコール脱水素酵素 / DROSHA / ウイルス感染 / 発症機序 / 内膜症性卵巣囊腫 / 卵巣内膜症性嚢胞 / 子宮内膜症性嚢胞 / 炎症 / 獲得免疫 / preterm birth / 子宮筋層 / 樹状細胞遊走因子 / 子宮形成術 / 着床不全 / RANTES / CD141+ 樹状細胞（DC） / 子宮鏡下中隔切除術 / ケモカインレセプター / ケモカイン / 流産 / 不育症 / 中隔子宮 / 後期早産 / 絨毛膜羊膜炎 / 周産期 / 国際情報交換 / 細胞傷害性T細胞 / PD-L1 / 胎児抗原特異的CTL / B7-H1(PD-L1) Less

胎盤由来細胞間輸送体の新パラダイムによる妊娠高血圧腎症・早産の病態解明と発症予知
- Principal Investigator
  
  瀧澤俊広
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
Multiomics analysis of exosome-delivering, virus-derived factors in the feto-matarnal interface for hypertensive dosorder of pregnancy
- Principal Investigator
  
  磯村真理子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
Establishment of a new therapeutic strategy for preterm labor focused on anti-inflammationPrincipal Investigator
- Principal Investigator
  
  根岸靖幸
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
ClassⅢアルコール脱水素酵素による飲酒後骨粗鬆症の新規治療開発
- Principal Investigator
  
  枝重光洋
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo Women's Medical University
sterile inflammation as a possible cause of fetal growth restriction: exploring the connection between later lifestyle-related diseases
- Principal Investigator
  
  島義雄
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nippon Medical School
自然免疫を標的とした新たな閉経後骨粗鬆症メカニズム解析と発症予防・治療薬の開発
- Principal Investigator
  
  大内望
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
新規治療法開発を指向した子宮内膜症におけるアラーミンとその受容体の免疫学的解析
- Principal Investigator
  
  池田真利子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
Elucidation of the novel function of trophoblast DROSHA as a novel therapeutic strategy for preventing congenital viral infection
- Principal Investigator
  
  Takizawa Toshihiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
New therapeutic strategies for miscarriage and preterm birth by regulation of innate immunityPrincipal Investigator
- Principal Investigator
  
  Negishi Yasuyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
Sterile Inflammation - A novel approach to preterm birth -
- Principal Investigator
  
  SHIMA YOSHIO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Nippon Medical School
Novel mechanism of endometrial ovarian cyst related to sterile inflammation
- Principal Investigator
  
  Ikeda Mariko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
Alcohol dehydrogenase in alcohol-related organ disorder
- Principal Investigator
  
  OKUDA Takahisa
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nihon University
Analysis of possible mechanism of miscarriage in women with septate uterus
- Principal Investigator
  
  Takeshita Toshiyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Nippon Medical School
Therapeutic approach for unexplained abortion and preterm birth by glycolipid antigens: an immunological perspectivePrincipal Investigator
- Principal Investigator
  
  Negishi Yasuyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nippon Medical School
Investigation of preterm birth from the view point of innate immunity
- Principal Investigator
  
  Shima Yoshio
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Nippon Medical School
Kinetics of fetal-antigen specific cytotoxic T cell (CTL) and protection role of placenta for feto-maternal tolerance
- Principal Investigator
  
  ICHIKAWA MASAO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Nippon Medical School

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] 臨床免疫・アレルギー科2020
- Author(s)
  根岸靖幸
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20K09679
[Journal Article] Cytoplasmic and nuclear DROSHA in human villous trophoblasts2024
- Author(s)
  Noguchi Syunya、Ohkura Sadayuki、Negishi Yasuyuki、Tozawa Shohei、Takizawa Takami、Morita Rimpei、Takahashi Hironori、Ohkuchi Akihide、Takizawa Toshihiro
- Journal Title
  
  Journal of Reproductive Immunology
  
  Volume: 162 Pages: 104189-104189
- DOI
  10.1016/j.jri.2023.104189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16843, KAKENHI-PROJECT-22K07140, KAKENHI-PROJECT-20K09611
[Journal Article] Downregulation of pattern recognition receptors on macrophages involved in aggravation of endometriosis2024
- Author(s)
  Shiraishi Tatsunori、Ikeda Mariko、Watanabe Takami、Negishi Yasuyuki、Ichikawa Go、Kaseki Hanako、Akira Shigeo、Morita Rimpei、Suzuki Shunji
- Journal Title
  
  American Journal of Reproductive Immunology
  
  Volume: 91 Issue: 1
- DOI
  10.1111/aji.13812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09652
[Journal Article] Oxidative Stress and Antioxidant Capacity in Patients with Endometrioma2024
- Author(s)
  Ichikawa Go、Negishi Yasuyuki、Tsuchiya Ryo、Higuchi Lilika、Shiraishi Tatsunori、Ikeda Mariko、Kaseki Hanako、Morita Rimpei、Suzuki Shunji
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 91 Issue: 2 Pages: 146-154
- DOI
  10.1272/jnms.JNMS.2024_91-204
- ISSN
  1345-4676, 1347-3409
- Year and Date
  2024-04-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09652
[Journal Article] Inflammation in preterm birth: Novel mechanism of preterm birth associated with innate and acquired immunity2022
- Author(s)
  Negishi Y, Shima Y, Kato M, Ichikawa T, Ino H, Horii Y, Suzuki S, Morita R.
- Journal Title
  
  J Reprod Immunol .
  
  Volume: 154 Pages: 103748-103748
- DOI
  10.1016/j.jri.2022.103748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07140, KAKENHI-PROJECT-22K07853, KAKENHI-PROJECT-22K16887, KAKENHI-PROJECT-20K09679
[Journal Article] Inflammation in Preterm Birth2022
- Author(s)
  Negishi Yasuyuki
- Journal Title
  
  Nihon Ika Daigaku Igakkai Zasshi
  
  Volume: 18 Issue: 2 Pages: 194-201
- DOI
  10.1272/manms.18.194
- ISSN
  1349-8975, 1880-2877
- Year and Date
  2022-04-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09679
[Journal Article] Upregulated serum granulysin levels in women with antiphospholipid antibody‐associated recurrent miscarriage are downregulated by heparin treatment2022
- Author(s)
  Ichikawa Tomoko、Negishi Yasuyuki、Kasano Sayuri、Yokote Ryoko、Yonezawa Mirei、Ouchi Nozomi、Kuwabara Yoshimitsu、Suzuki Shunji、Takeshita Toshiyuki
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 21 Issue: 1 Pages: 1-9
- DOI
  10.1002/rmb2.12460
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16867, KAKENHI-PROJECT-20K09679
[Journal Article] Placenta-specific lncRNA 1600012P17Rik is expressed in spongiotrophoblast and glycogen trophoblast cells of mouse placenta2022
- Author(s)
  Junxiao Wang, Syunya Noguchi, Takami Takizawa, Yasuyuki Negishi, Rimpei Morita, Shan-Shun Luo, Toshihiro Takizawa
- Journal Title
  
  Histochem Cell Biol
  
  Volume: 158 Issue: 1 Pages: 65-78
- DOI
  10.1007/s00418-022-02109-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09611, KAKENHI-PROJECT-22K07140, KAKENHI-PROJECT-22K16843
[Journal Article] Inflammation related to high-mobility group box-1 in endometrial ovarian cyst2021
- Author(s)
  Ikeda Mariko、Negishi Yasuyuki、Akira Shigeo、Morita Rimpei、Takeshita Toshiyuki
- Journal Title
  
  Journal of Reproductive Immunology
  
  Volume: 145 Pages: 103292-103292
- DOI
  10.1016/j.jri.2021.103292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09813, KAKENHI-PROJECT-20K09679
[Journal Article] Sustained sterile inflammation is related to pulmonary morbidities in premature infants2021
- Author(s)
  Shima Yoshio、Kumasaka Sakae、Negishi Yasuyuki
- Journal Title
  
  The Journal of Maternal-Fetal & Neonatal Medicine
  
  Volume: 1 Issue: 25 Pages: 1-5
- DOI
  10.1080/14767058.2021.1931102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08331, KAKENHI-PROJECT-20K09679
[Journal Article] Alcohol consumption induces murine osteoporosis by downregulation of natural killer T‐like cell activity2021
- Author(s)
  Naruo Munehiro、Negishi Yasuyuki、Okuda Takahisa、Katsuyama Midori、Okazaki Ken、Morita Rimpei
- Journal Title
  
  Immunity, Inflammation and Disease
  
  Volume: 9 Issue: 4 Pages: 1370-1382
- DOI
  10.1002/iid3.485
- NAID
  120007183291
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H04038, KAKENHI-PROJECT-20K09512, KAKENHI-PROJECT-20K09679
[Journal Article] Inappropriate activation of invariant natural killer T cells and antigen‐presenting cells with the elevation of HMGB1 in preterm births without acute chorioamnionitis2020
- Author(s)
  Kato Masahiko、Negishi Yasuyuki、Shima Yoshio、Kuwabara Yoshimitsu、Morita Rimpei、Takeshita Toshiyuki
- Journal Title
  
  American Journal of Reproductive Immunology
  
  Volume: 85 Issue: 1
- DOI
  10.1111/aji.13330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08331, KAKENHI-PROJECT-20K09679
[Journal Article] Distribution of dendritic cells in the septate uterus: An immunological perspective.2020
- Author(s)
  Negishi Y1,2, Kato M2, Ono S2, Kuwabara Y2, Morita R1, Takahashi H1, Takeshita T2.
- Journal Title
  
  Am J Reprod Immunol.
  
  Volume: e13241 Issue: 6
- DOI
  10.1111/aji.13241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09304, KAKENHI-PROJECT-16H05178
[Journal Article] Harmful and beneficial effects of inflammatory response on reproduction: sterile and pathogen-associated inflammation2020
- Author(s)
  Negishi Yasuyuki、Shima Yoshio、Takeshita Toshiyuki、Morita Rimpei
- Journal Title
  
  Immunological Medicine
  
  Volume: - Issue: 2 Pages: 1-18
- DOI
  10.1080/25785826.2020.1809951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08331, KAKENHI-PROJECT-20K09679, KAKENHI-PROJECT-18K09304
[Journal Article] A combination of check-point blockade and α-galactosylceramide elicits longlasting suppressive effects on murine hepatoma cell growth in vivo2020
- Author(s)
  Ishii, K, Shimizu, M, Kogo, H, Tamura, H, Negishi, Y, Morita, R, Takahashi, H
- Journal Title
  
  Immunobiology
  
  Volume: 225 Issue: 1 Pages: 151860-151860
- DOI
  10.1016/j.imbio.2019.10.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11255
[Journal Article] Induction of tumor-specific CD8+ cytotoxic T lymphocytes from naive human T cells by using Mycobacterium-derived mycolic acid and lipoarabinomannan-stimulated dendritic cells2019
- Author(s)
  Tomita Y, Watanabe E, Shimizu M, Negishi Y, Kondo Y, Takahashi H
- Journal Title
  
  Cancer immunology, immunotherapy
  
  Volume: 68 Issue: 10 Pages: 1605-1619
- DOI
  10.1007/s00262-019-02396-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11255
[Journal Article] Innate immune cells in reproduction2018
- Author(s)
  Negishi Yasuyuki、Takahashi Hidemi、Kuwabara Yoshimitsu、Takeshita Toshiyuki
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 44 Issue: 11 Pages: 2025-2036
- DOI
  10.1111/jog.13759
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11255, KAKENHI-PROJECT-16K09262
[Journal Article] Miscarriage induced by adoptive transfer of dendritic cells and invariant natural killer T cells into mice2018
- Author(s)
  Negishi Yasuyuki、Ichikawa Tomoko、Takeshita Toshiyuki、Takahashi Hidemi
- Journal Title
  
  European Journal of Immunology
  
  Volume: 48 Issue: 6 Pages: 937-949
- DOI
  10.1002/eji.201747162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11255, KAKENHI-PROJECT-16K09262
[Journal Article] Distribution of invariant natural killer T cells and dendritic cells in late pre-term birth without acute chorioamnionitis2017
- Author(s)
  Negishi, Y. Shima, Y. Takeshita, T. Takahashi, H.
- Journal Title
  
  American Journal of Reproductive Immunology
  
  Volume: - Issue: 6
- DOI
  10.1111/aji.12658
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11255, KAKENHI-PROJECT-15K09731, KAKENHI-PROJECT-16K09262
[Journal Article] 樹状細胞による妊娠、分娩の制御2014
- Author(s)
  根岸　靖幸
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 62(6) Pages: 604-608
- Data Source
  KAKENHI-PROJECT-24592487
[Presentation] Downregulation of innate immune cells in postmenopausal osteoporosis: A novel osteoimmunological perspective2024
- Author(s)
  22.Yasuyuki Negishi
- Organizer
  第55回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09558
[Presentation] ClassⅢアルコール脱水素酵素はマウス皮質骨のコラーゲン配向性を制御する2023
- Author(s)
  成尾宗浩、根岸靖幸、奥田貴久、森田林平
- Organizer
  日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19H04038
[Presentation] 閉経後骨粗鬆症モデルマウスにおける免疫系のダウンレギュレーション―新たな発症メカニズムの考察―2023
- Author(s)
  樋口百合花、根岸靖幸、成尾宗浩、大内　望、鈴木俊治、奥田貴久、森田林平
- Organizer
  日本骨免疫学会
- Data Source
  KAKENHI-PROJECT-19H04038
[Presentation] Role of immune cells in preterm birth induced by sterile inflammation2023
- Author(s)
  Yasuyuki Negishi
- Organizer
  The 1st Asian Congress for Reproductive Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07853
[Presentation] 自然免疫をターゲットとした早産の新規治療作用点の模索2023
- Author(s)
  根岸靖幸
- Organizer
  第51回日本臨床免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07853
[Presentation] 栄養膜細胞株BeWoを用いたウイルス感染における栄養膜細胞DROSHAの動態解析2023
- Author(s)
  野口隼矢、大倉定之、根岸靖幸、森田林平、大口昭英、高橋宏典、瀧澤俊広
- Organizer
  第31回日本胎盤学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] 胎盤絨毛栄養膜細胞のmiRNA生合成酵素DROSHAに結合するRNA：fCLIP解析2023
- Author(s)
  瀧澤俊広、野口隼矢、大倉定之、根岸靖幸、森田林平、大口昭英、高橋宏典
- Organizer
  第31回日本胎盤学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09611
[Presentation] プロゲステロンの流早産予防効果―その作用点と抗炎症効果の免疫学的機序―2022
- Author(s)
  飯田彩実、根岸靖幸、井野　創、堀井裕美、島　義雄、鈴木俊治、森田林平
- Organizer
  第50回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] プロゲステロンは自然免疫系に作用して流早産予防効果を発揮する2022
- Author(s)
  石橋あずさ、根岸靖幸、島義雄、鈴木俊治、森田林平
- Organizer
  第58回日本周産期・新生児医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] Sterile inflammation in preterm birth2022
- Author(s)
  Yasuyuki Negishi
- Organizer
  Preterm Birth International Collaborative (PREBIC) Australasia Workshop
- Invited
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 生殖免疫における炎症-その役割と功罪-2022
- Author(s)
  根岸靖幸
- Organizer
  第37回日本生殖免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 子宮筋層からのIL-18産生は正常な胎盤形成および胎児発育に寄与する2022
- Author(s)
  井野　創、堀井裕美、根岸靖幸、小池恵理、鈴木俊治、森田林平
- Organizer
  第30回日本胎盤学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] Progesterone prevents murine miscarriage by suppressing the immunostimulatory activity of macrophage2022
- Author(s)
  Yasuyuki Negishi, Hajime Ino, Yumi Horii, Eri Koike, Yoshio Shima, Shunji Suzuki, Rimpei Morita
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 炎症性サイトカインIL-18は正常な胎盤形成および胎児発育に寄与する2022
- Author(s)
  井野　創、堀井裕美、根岸靖幸、小池恵理、鈴木俊治、森田林平
- Organizer
  第37回日本生殖免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] プロゲステロンの流早産予防効果―その作用点と抗炎症効果の免疫学的機序―2022
- Author(s)
  飯田彩実、根岸靖幸、井野　創、堀井裕美、島　義雄、鈴木俊治、森田林平
- Organizer
  第50回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-22K07853
[Presentation] プロゲステロンは自然免疫系に作用して流早産予防効果を発揮する2022
- Author(s)
  石橋あずさ、根岸靖幸、島義雄、鈴木俊治、森田林平
- Organizer
  第58回日本周産期・新生児医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07853
[Presentation] 早産発症の免疫学的アプローチ－絨毛膜羊膜炎の有無による免疫細胞動態の相違－”2022
- Author(s)
  根岸靖幸、島　義雄、加藤雅彦、井野　創、堀井裕美、鈴木俊治、森田林平
- Organizer
  第38回日本産婦人科感染症学会
- Data Source
  KAKENHI-PROJECT-22K07853
[Presentation] 免疫と臨床栄養―不育症と早産を中心に2022
- Author(s)
  根岸靖幸、加藤雅彦、井野　創、清田裕美、島　義雄、鈴木俊治、森田林平
- Organizer
  第8回母子栄養懇談会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 早産発症の免疫学的アプローチ－絨毛膜羊膜炎の有無による免疫細胞動態の相違－2022
- Author(s)
  根岸靖幸、島　義雄、加藤雅彦、井野　創、堀井裕美、鈴木俊治、森田林平
- Organizer
  第38回日本産婦人科感染症学会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] Progesterone prevents murine miscarriage by suppressing the immunostimulatory activity of macrophage2022
- Author(s)
  Yasuyuki Negishi, Hajime Ino, Yumi Horii, Eri Koike, Yoshio Shima, Shunji Suzuki, Rimpei Morita
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07853
[Presentation] Inappropriate activation of innate immune cells in sterile inflammation in human preterm birth2021
- Author(s)
  Yasuyuki Negishi, Masahiko Kato, Yoshio Shima, Toshiyuki Takeshita, Shunji Suzuki, Rimpei Morita
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 脱落膜化細胞におけるインフラマソームを介した子宮内炎症機構の検討2021
- Author(s)
  市川　剛、根岸靖幸、市川智子、鈴木俊治
- Organizer
  第36回日本生殖免疫学会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 無菌性炎症が惹起する早産発症メカニズムの解明ー新規治療法の開発に向けて2021
- Author(s)
  根岸靖幸
- Organizer
  第73回日本産科婦人科学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 無菌性炎症に起因する早産ーヘパリン、プロゲステロンの作用点を再考するー2021
- Author(s)
  根岸靖幸、加藤雅彦、島　義雄、鈴木俊治、森田林平
- Organizer
  第29回日本胎盤学会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] Impact of innate immune cells and high mobility group box 1 (HMGB1) in preterm labor and rupture of membrane without acute chorioamnionitis2021
- Author(s)
  Masahiko Kato, Yasuyuki Negishi, Yoshio Shima, Rimpei Morita, Toshiyuki Takeshita
- Organizer
  第40回米国生殖免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] Impact of innate immune cells and high mobility group box 1 (HMGB1) in preterm labor and rupture of membrane without acute chorioamnionitis2021
- Author(s)
  Masahiko Kato, Yasuyuki Negishi, Yoshio Shima, Rimpei Morita, Toshiyuki Takeshita
- Organizer
  第40回米国生殖免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08331
[Presentation] 無菌性炎症に起因する早産ーヘパリン、プロゲステロンの作用点を再考するー2021
- Author(s)
  根岸靖幸、加藤雅彦、島　義雄、鈴木俊治、森田林平
- Organizer
  第29回日本胎盤学会
- Data Source
  KAKENHI-PROJECT-19K08331
[Presentation] 自然免疫を中心とした流産・早産に対するアプローチ2021
- Author(s)
  根岸靖幸
- Organizer
  第36回日本生殖免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] Role of innate immune cells in postmenopausal osteoporosis: An osteoimmunological perspective2021
- Author(s)
  Yasuyuki Negishi, Munehiro Naruo, Nozomi Ouchi, Takahisa Okuda, Toshiyuki Takeshita, Rimpei Morita
- Organizer
  第40回米国生殖免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 自然免疫の制御は早産の新しい治療作用点になり得るか？2021
- Author(s)
  根岸靖幸、加藤雅彦、井野　創、清田裕美、島　義雄、鈴木俊治、森田林平
- Organizer
  第49回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-19K08331
[Presentation] 自然免疫系からみた閉経後骨粗鬆症ー新たなメカニズム解明と新規治療法の展開にむけてー2021
- Author(s)
  中山英雅、根岸靖幸、大内　望、成尾宗浩、森田林平
- Organizer
  第49回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 免疫学的知見からみた中隔子宮における流産発症メカニズムの解析ー妊娠初期における炎症の功罪2021
- Author(s)
  根岸靖幸
- Organizer
  第39回日本受精着床学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 卵巣内膜症性嚢胞における免疫細胞およびHMGB1の動態2021
- Author(s)
  池田真利子、根岸靖幸、明樂重夫、森田林平、竹下俊行
- Organizer
  第42回日本エンドメトリオーシス学会
- Data Source
  KAKENHI-PROJECT-19K09813
[Presentation] 自然免疫の制御は早産の新しい治療作用点になり得るか？2021
- Author(s)
  根岸靖幸、加藤雅彦、井野　創、清田裕美、島　義雄、鈴木俊治、森田林平
- Organizer
  第49回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] nappropriate activation of innate immune cells in sterile inflammation in human preterm birth2021
- Author(s)
  Yasuyuki Negishi, Masahiko Kato, Yoshio Shima, Toshiyuki Takeshita, Shunji Suzuki, Rimpei Morita
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K08331
[Presentation] 無菌性炎症が関与する卵巣内膜症性嚢胞の病態- high mobility group box 1 (HMGB1)との関連-2021
- Author(s)
  池田真利子、根岸靖幸、森田林平、明樂重夫、鈴木俊治、竹下俊行
- Organizer
  第36回日本生殖免疫学会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 無菌性炎症が関与する卵巣内膜症性嚢胞の病態- high mobility group box 1 (HMGB1)との関連-2021
- Author(s)
  池田真利子、根岸靖幸、森田林平、明樂重夫、鈴木俊治、竹下俊行
- Organizer
  第36回日本生殖免疫学会
- Data Source
  KAKENHI-PROJECT-19K09813
[Presentation] プロゲステロンによるα-GC誘導性マウス流産の予防効果-新たな治療作用点を探る2020
- Author(s)
  根岸靖幸、桑原慶充、竹下俊行、森田林平
- Organizer
  第28回日本胎盤学会
- Data Source
  KAKENHI-PROJECT-20K09679
[Presentation] 中隔子宮と流産－免疫学的メカニズムから考察する2020
- Author(s)
  根岸靖幸1, 2、加藤雅彦2、森田林平1、竹下俊行2
- Organizer
  第72回日本産科婦人科学会：2020/4/23-4/287
- Data Source
  KAKENHI-PROJECT-18K09304
[Presentation] Septate uterus and recurrent pregnancy loss: An immunological perspective2020
- Author(s)
  Masahiko Kato1, Yasuyuki Negishi1,2, Tomoko Ichikawa1, Hidemi Takahashi2, Toshiyuki Takeshita1
- Organizer
  第33回日本生殖免疫学会
- Data Source
  KAKENHI-PROJECT-18K09304
[Presentation] 免疫学的知見による新しい流早産発症メカニズムの解明2020
- Author(s)
  根岸靖幸1、加藤雅彦2、島義雄3、市川智子2、竹下俊行2、森田林平1、高橋秀実1
- Organizer
  第47回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K09304
[Presentation] アルコール過量摂取に伴う続発性骨粗鬆症における自然免疫細胞の役割.2020
- Author(s)
  成尾宗浩, 根岸靖幸, 奥田貴久, 岡崎賢, 森田林平
- Organizer
  第93回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-19H04038
[Presentation] 免疫学的考察による中隔子宮の流産発症機構2020
- Author(s)
  根岸　靖幸1,2、加藤　雅彦2、森田　林平1、竹下　俊行2
- Organizer
  第65回日本生殖医学会
- Data Source
  KAKENHI-PROJECT-18K09304
[Presentation] 中隔子宮における流産発症メカニズムの免疫学的考察2020
- Author(s)
  根岸　靖幸1,2、加藤　雅彦2、竹下　俊行2、森田　林平
- Organizer
  第48回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-18K09304
[Presentation] 絨毛膜羊膜炎を伴わない原因不明早産メカニズムの解析：自然免疫制御による新しい治療作用点を探る2020
- Author(s)
  加藤雅彦、根岸靖幸、島義雄、森田林平、竹下俊行
- Organizer
  第48回日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-19K08331
[Presentation] 中隔子宮における自然免疫の役割〜免疫学的見地から中隔子宮と不育症の関係を考える2020
- Author(s)
  根岸靖幸1, 2、小野修一2、森田林平1、竹下俊行2
- Organizer
  第2回日本不育症学会
- Data Source
  KAKENHI-PROJECT-18K09304
[Presentation] 絨毛膜羊膜炎を伴わない早産における自然免疫およびHMGB1の役割-ヘパリンの新たな作用点を探る2020
- Author(s)
  加藤雅彦、根岸靖幸、島義雄、森田林平、竹下俊行
- Organizer
  第35回日本生殖免疫学会
- Data Source
  KAKENHI-PROJECT-19K08331
[Presentation] 無菌性炎症に起因する流早産発症メカニズムと自然免疫の役割2019
- Author(s)
  根岸　靖幸
- Organizer
  第71回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-19K08331
[Presentation] 免疫学的知見による新しい流早産発症メカニズムの解明2019
- Author(s)
  根岸　靖幸
- Organizer
  第47回日本臨床免疫学
- Invited
- Data Source
  KAKENHI-PROJECT-19K08331
[Presentation] 絨毛膜羊膜炎を伴わない原因不明早産の免疫学的解析－無菌性炎症からのアプローチ2019
- Author(s)
  根岸　靖幸
- Organizer
  第27回日本胎盤学会（学会賞（相馬賞）受賞）
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] 多臓器を対象としたアルコール基礎研究の問題点2019
- Author(s)
  奥田貴久, 勝山碧, 長谷場健, 成尾宗浩, 根岸靖幸
- Organizer
  2019年度アルコール薬物依存関連学会合同学術総会
- Data Source
  KAKENHI-PROJECT-19H04038
[Presentation] 免疫学的知見による新しい流早産発症メカニズムの解明2019
- Author(s)
  根岸　靖幸
- Organizer
  第47回日本臨床免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] Role of innate immune cells in murine and human reproduction2019
- Author(s)
  Yasuyuki Negishi
- Organizer
  第14回国際生殖免疫学会（第34回日本生殖免疫学会合同開催）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] 絨毛膜羊膜炎を伴わない原因不明早産の免疫学的解析－無菌性炎症からのアプローチ2019
- Author(s)
  根岸　靖幸
- Organizer
  第27回日本胎盤学会
- Data Source
  KAKENHI-PROJECT-19K08331
[Presentation] アルコール性骨粗鬆症についての免疫学的考察2019
- Author(s)
  奥田貴久, 成尾宗浩, 根岸靖幸，勝山碧，長谷場健，大野曜吉
- Organizer
  第103回日本法医学会学術全国集会
- Data Source
  KAKENHI-PROJECT-19H04038
[Presentation] Immunological aspect of uterine septum in women with recurrent pregnancy loss2019
- Author(s)
  Toshiyuki Takeshita1, Ph.D. Yasuyuki Negishi 1,2, Masahiko Kato1, Shuichi Ono1, Hidemi Takahashi
- Organizer
  ISIR 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09304
[Presentation] 無菌性炎症に起因する流早産発症メカニズムと自然免疫の役割2019
- Author(s)
  根岸　靖幸
- Organizer
  第71回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] Role of innate immune cells in murine and human reproduction2019
- Author(s)
  Yasuyuki Negishi
- Organizer
  The 14th World Congress of International Society for Immunology of Reproduction (ISIR 2019)/The 34th Annual Meeting of the Japanese Society for Immunology of Reproduction (34th JSIR)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08331
[Presentation] Role of dendritic cells and invariant natural killer T cells in glycolipid antigen-induced murine miscarriage2018
- Author(s)
  根岸　靖幸
- Organizer
  第47回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] Miscarriage induced by activated innate immune cells in mice2018
- Author(s)
  根岸　靖幸
- Organizer
  American-Sino Joint Meeting of Reproductive Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] Distribution and kinetics of immune cells in decidua for extreme to moderate preterm births without acute chorioamnionitis2018
- Author(s)
  根岸　靖幸
- Organizer
  第24回国際胎盤学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] 糖脂質抗原α-galactosylceramideによって活性化された樹状細胞、invariant natural killer T細胞はマウス流産を引き起こす2018
- Author(s)
  根岸　靖幸
- Organizer
  第33回日本生殖免疫学会
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] Accumulation of dendritic cells and invariant natural killer T cells in the decidua of late preterm birth without acute chorioamnionitis2017
- Author(s)
  Yasuyuki Negishi, Yoshio Shima, Toshiyuki Takeshita, Hidemi Takahashi
- Organizer
  The 37th Annual Meeting of the American Society for Reproductive Immunology
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] Adoptive transfer of innate immune cells induce murine fetal loss2017
- Author(s)
  Yasuyuki Negishi, Tomoko Ichikawa, Eri Watanabe, Hikaru Takeshita, Toshiyuki Takeshita, Hidemi Takahashi
- Organizer
  第46回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] Functional difference between decidual dendritic cells in late preterm birth with and without acute chorioamnionitis2017
- Author(s)
  Yasuyuki Negishi, Yoshio Shima, Hidemi Takahashi, Toshiyuki Takeshita
- Organizer
  第25回日本胎盤学会
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] Role of innate immune cells in preterm birth and miscarriages induced by sterile inflammation in mice and humans2017
- Author(s)
  Yasuyuki Negishi, Tomoko Ichikawa, Yoshio Shima, Toshiyuki Takeshita, Hidemi Takahashi
- Organizer
  第32回日本生殖免疫学会
- Data Source
  KAKENHI-PROJECT-15K09731
[Presentation] Role of innate immune cells in preterm birth and miscarriages induced by sterile inflammation in mice and humans2017
- Author(s)
  Yasuyuki Negishi, Tomoko Ichikawa, Yoshio Shima, Toshiyuki Takeshita, Hidemi Takahashi
- Organizer
  第32回日本生殖免疫学会
- Data Source
  KAKENHI-PROJECT-17K11255
[Presentation] Functional difference between decidual dendritic cells in late preterm birth with and without acute chorioamnionitis2017
- Author(s)
  Yasuyuki Negishi, Yoshio Shima, Hidemi Takahashi, Toshiyuki Takeshita
- Organizer
  第25回日本胎盤学会
- Data Source
  KAKENHI-PROJECT-15K09731
[Presentation] Accumlation of dendritic cells and invariant natural killer T cells in the decidua of late preterm birth without acute chorioamnionitis2017
- Author(s)
  Yasuyuki Negishi, Yoshio Shima, Hidemi Takahashi, Toshiyuki Takeshita
- Organizer
  37th Annual Meeting of the American Society for Reproductive Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09731
[Presentation] 自然免疫から考える後期早産2017
- Author(s)
  島　義雄、根岸靖幸、竹下俊行、高橋秀実
- Organizer
  第53回日本周産期・新生児医学会
- Data Source
  KAKENHI-PROJECT-15K09731
[Presentation] 自然炎症としての後期早産2017
- Author(s)
  島　義雄、根岸靖幸、竹下俊行、高橋秀実
- Organizer
  第62回新生児成育医学会
- Data Source
  KAKENHI-PROJECT-15K09731
[Presentation] Kinetics of dendritic cells, NK cells and natural killer T cells in the late preterm delivery without Chorioamnionitis2016
- Author(s)
  Negishi, Y., Shima, Y., Takeshita, T., Takahashi, H.
- Organizer
  第31回日本生殖免疫学会
- Place of Presentation
  神戸
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-15K09731
[Presentation] Role of DEC-205 positive dendritic cells in moderately and late preterm delivery2015
- Author(s)
  Y. Negishi, Y. Shima, H. Takahashi, T. Takeshita
- Organizer
  第23日本胎盤学会
- Place of Presentation
  東京
- Year and Date
  2015-11-05
- Data Source
  KAKENHI-PROJECT-15K09731
[Presentation] 後期早産の胎盤におけるDEC-205陽性樹状細胞の役割2015
- Author(s)
  根岸靖幸、島義雄、西田直子、朝倉啓文、竹下俊行、高橋秀実
- Organizer
  第67回日本産科婦人科学会
- Place of Presentation
  東京
- Year and Date
  2015-04-09
- Data Source
  KAKENHI-PROJECT-15K09731
[Presentation] Effects of glycolipid antigens on the differentiation of dendritic cells in pregnancy
- Author(s)
  根岸　靖幸
- Organizer
  第30回日本生殖免疫学会
- Place of Presentation
  京都
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-24592487
[Presentation] Different roles of IL-13 for the fetal loss induced by IL-12 treatment or 33D1+DC depletion in mice
- Author(s)
  根岸　靖幸
- Organizer
  第34回米国生殖免疫学会
- Place of Presentation
  アメリカ
- Year and Date
  2014-06-02 – 2014-06-05
- Data Source
  KAKENHI-PROJECT-24592487
[Presentation] Effects of glycolipid antigens on the differentiation of dendritic cells
- Author(s)
  根岸　靖幸
- Organizer
  第43回日本免疫学会
- Place of Presentation
  東京
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24592487

1. 桑原慶充 (40373013)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. Shima Yoshio (70714765)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
3. 成尾宗浩 (00772310)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. TAKESHITA Toshiyuki (60188175)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. Ikeda Mariko (10740988)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. Takizawa Toshihiro (90271220)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. 大口昭英 (10306136)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. 高橋宏典 (80544303)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. 大倉定之 (10731036)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
10. ICHIKAWA MASAO (20366660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OKUDA Takahisa (20620305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. 里見操緒 (80318500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小野修一 (80465301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 明樂重夫 (40231849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 五十嵐勉 (10421190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 草野麻衣子 (60733574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 高成広起 (70723253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 勝山碧 (90803700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. 大内望 (10445752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 野口隼矢 (30879698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. 磯村真理子 (90893222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 堀江真行 (20725981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 石野孔祐 (60584878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 加藤雅彦 (90614751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 枝重光洋 (50940467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 森田林平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 市川智子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Negishi Yasuyuki 根岸 靖幸

NEGISHI Yasuyuki 根岸 靖幸

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Establishment of a new therapeutic strategy for preterm labor focused on anti-inflammationPrincipal Investigator

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New therapeutic strategies for miscarriage and preterm birth by regulation of innate immunityPrincipal Investigator

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Therapeutic approach for unexplained abortion and preterm birth by glycolipid antigens: an immunological perspectivePrincipal Investigator

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Negishi Yasuyuki 根岸靖幸

NEGISHI Yasuyuki 根岸靖幸