TOYAMA TAKASHI 外山喬士

Researcher Number	50720918
Other IDs
Affiliation (Current)	2025: 東北大学, 薬学研究科, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 東北大学, 薬学研究科, 講師 2015 – 2022: 東北大学, 薬学研究科, 助教 2015: 東北大学, 薬学研究科(研究院), 助教 2015: 東北大学, 大学院薬学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Medium-sized Section 63:Environmental analyses and evaluation and related fields / Complex systems / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Environmental and hygienic pharmacy Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Risk sciences of radiation and chemicals / Basic Section 63030:Chemical substance influence on environment-related
Keywords	Principal Investigator メチル水銀 / セレノプロテインP / リソソーム / 共有結合 / 超硫黄 / 活性酸素種 / 重金属 / 解毒隔離 / 還元 / ApoER2 … More / セレノシステイン / GPx / セレン / グルタチオンペルオキシダーゼ / Se-水銀化 / 神経障害 / TNF-α / ミクログリア / 炎症性サイトカイン / ストレス / 衛生 / 細胞外因子 / メタボローム / 酸化ストレス / 細胞外放出因子 … More Except Principal Investigator メチル水銀 / セレノプロテイン / メタロミクス / 毒性 / レドックス制御 / セレノプロテインＰ / コホート研究 / ICP-MS / 亜鉛 / がん / 生活習慣病 / セレン / 転写因子 / シグナル伝達 / 酸性化 / ライソゾーム / 分泌タンパク質 / LTBR / 疾患予防 / 慢性疾患 / 鉄 / 糖尿病 / 水銀 / lncRNA / スルフォラフェン / NRF2 / 発現制御 / 2型糖尿病 / 重金属 / 地域住民コホート / インスリン抵抗性 / インスリン分泌 / アポトーシス / SRXN1 / TCF3 / 神経細胞死 / 毒性軽減 / プトレシン / トキシコロジー / 蛋白質 / 環境 / 脳神経疾患 / 有害化学物質 / オートクライン / 転写調節 / オートファジー Less

Elucidation of the molecular pathology of chronic diseases and establishment of new treatment methods based on trace element research
- Principal Investigator
  
  斎藤芳郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Elucidation of the direct metabolic control mechanisms of producing cells by secreted proteins
- Principal Investigator
  
  斎藤芳郎
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
A New Aspect of Selenoprotein P as Sequestration Factor against heavy metalsPrincipal Investigator
- Principal Investigator
  
  外山喬士
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tohoku University
リンホトキシンβ受容体を介したメチル水銀による脳神経障害機構の解明
- Principal Investigator
  
  黄基旭
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Lysosomal redox control via hepatic-brain crosstalk and its disruption by methylmercuryPrincipal Investigator
- Principal Investigator
  
  Toyama Takashi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Tohoku University
Creation of "disease metallomics" to understand the relationship between fluctuations of heavy metals/trace elements and diseases
- Principal Investigator
  
  Saito Yoshiro
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Disruption of redox status via an essential-metal and harmful-metal interactionPrincipal Investigator
- Principal Investigator
  
  外山喬士
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tohoku University
Regulatory mechanism of selenoprotein P expression and its deterioration mechanism of glucose metabolism
- Principal Investigator
  
  Saito Yoshiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tohoku University
Methylmercury induced neuronal damage via M1-microglial activationPrincipal Investigator
- Principal Investigator
  
  Toyama Takashi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tohoku University
Investigation of the defense mechanisms by the transcription factor TCF3 against methylmercury toxicity
- Principal Investigator
  
  Hwang Gi-Wook
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
  Tohoku University
Cytostatic factor that released from methylmercury exposed cellsPrincipal Investigator
- Principal Investigator
  
  Takashi Toyama
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Tohoku University
Mechanism underlying the reduction of methylmercury toxicity by putrescine
- Principal Investigator
  
  Hwang Gi-Wook
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Tohoku University
Molecular mechanism for toxic effect of methylmercury
- Principal Investigator
  
  NAGANUMA AKIRA
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Tohoku University
Mechanism underlying the reduction of methylmercury toxicity by Ragulator complex which is an autophagy regulator
- Principal Investigator
  
  HWANG Gi-Wook
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book Patent

[Book] セレンによる超硫黄分子ターンオーバー2021
- Author(s)
  外山喬士、斎藤芳郎
- Total Pages
  6
- Publisher
  生化学
- Data Source
  KAKENHI-PROJECT-21K19321
[Book] 生命金属ダイナミクス：生体内における金属の挙動と制御2021
- Author(s)
  外山　喬士
- Total Pages
  564
- Publisher
  エヌ・ティー・エス出版
- Data Source
  KAKENHI-PUBLICLY-20H05493
[Book] セレンによる超硫黄分子ターンオーバー2021
- Author(s)
  外山喬士、斎藤芳郎
- Total Pages
  6
- Publisher
  生化学
- Data Source
  KAKENHI-PROJECT-20H00488
[Book] 特集微量元素欠乏 (亜鉛セレン等) と疾患2021
- Author(s)
  外山　喬士、工藤　琉那、斎藤　芳郎
- Total Pages
  54
- Publisher
  Medical Science Digest
- Data Source
  KAKENHI-PUBLICLY-20H05493
[Journal Article] Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage2024
- Author(s)
  Zheng Xi、Toyama Takashi、Siu Stephanie、Kaneko Takayuki、Sugiura Hikari、Yamashita Shota、Shimoda Yoshiteru、Kanamori Masayuki、Arisawa Kotoko、Endo Hidenori、Saito Yoshiro
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 682-682
- DOI
  10.1038/s41598-024-51259-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H04796, KAKENHI-ORGANIZER-21H05258, KAKENHI-PROJECT-23K28236
[Journal Article] Methylmercury directly modifies the 105th cysteine residue in oncostatin M to promote binding to tumor necrosis factor receptor 3 and inhibit cell growth2023
- Author(s)
  Toyama Takashi、Xu Sidi、Kanemitsu Yoshitomi、Hasegawa Takashi、Noguchi Takuya、Lee Jin-Yong、Matsuzawa Atsushi、Naganuma Akira、Hwang Gi-Wook
- Journal Title
  
  Archives of Toxicology
  
  Volume: 97 Issue: 7 Pages: 1887-1897
- DOI
  10.1007/s00204-023-03520-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07713, KAKENHI-PROJECT-23K25006
[Journal Article] Methylmercury directly modifies the 105th cysteine residue in oncostatin M to promote binding to tumor necrosis factor receptor 3 and inhibit cell growth2023
- Author(s)
  Toyama Takashi、Xu Sidi、Hasegawa Takashi、Kanemitsu Yoshitomi、Noguchi Takuya、Lee Jin-Yong、Matsuzawa Atsushi、Naganuma Akira, Hwang Gi-Wook
- Journal Title
  
  Archives of Toxicology
  
  Volume: 97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K25006
[Journal Article] Sulforaphane decreases serum selenoprotein P levels through enhancement of lysosomal degradation independent of Nrf22023
- Author(s)
  Ye Xinying、Toyama Takashi、Taguchi Keiko、Arisawa Kotoko、Kaneko Takayuki、Tsutsumi Ryouhei、Yamamoto Masayuki、Saito Yoshiro
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1060-1060
- DOI
  10.1038/s42003-023-05449-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H04796, KAKENHI-ORGANIZER-21H05258, KAKENHI-PROJECT-23K28236
[Journal Article] Role of selenoprotein P expression in the function of pancreatic β cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation2022
- Author(s)
  Kitabayashi Nanako、Nakao Shohei、Mita Yuichiro、Arisawa Kotoko、Hoshi Takayuki、Toyama Takashi、Ishii Kiyo-aki、Takamura Toshinari、Noguchi Noriko、Saito Yoshiro
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 183 Pages: 89-103
- DOI
  10.1016/j.freeradbiomed.2022.03.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11770, KAKENHI-PROJECT-17H04199, KAKENHI-PROJECT-18K08507, KAKENHI-PROJECT-21K08573, KAKENHI-PROJECT-22K06606, KAKENHI-PUBLICLY-22H05579, KAKENHI-PUBLICLY-22H04796, KAKENHI-PROJECT-21K19321, KAKENHI-PLANNED-21H05270, KAKENHI-PROJECT-20H00488
[Journal Article] Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia2021
- Author(s)
  Toyama T, Hoshi T, Noguchi T, Saito Y, Matsuzawa A, Naganuma A, Hwang G. W.
- Journal Title
  
  Scientific Reports
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16345
[Journal Article] Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia2021
- Author(s)
  Toyama Takashi、Hoshi Takayuki、Noguchi Takuya、Saito Yoshiro、Matsuzawa Atsushi、Naganuma Akira、Hwang Gi-Wook
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 9831-9831
- DOI
  10.1038/s41598-021-89210-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05491, KAKENHI-PUBLICLY-21H00268, KAKENHI-PROJECT-19H04276, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-21K19325, KAKENHI-PROJECT-21K19321, KAKENHI-PROJECT-20H00488
[Journal Article] Increased expression of TCF3, transcription factor 3, is a defense response against methylmercury toxicity in mouse neuronal C17.2 cells2021
- Author(s)
  Toyama Takashi、Wang Yanjiao、Kim Min-Seok、Takahashi Tsutomu、Naganuma Akira、Hwang Gi-Wook
- Journal Title
  
  Toxicological Research
  
  Volume: 22 Issue: 4 Pages: 1-8
- DOI
  10.1007/s43188-021-00087-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05493, KAKENHI-PROJECT-19K16345, KAKENHI-PROJECT-19H04276
[Journal Article] Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia2021
- Author(s)
  Takashi Toyama, Takayuki Hoshi, Takuya Noguchi, Yoshiro Saito, Atsushi Matsuzawa, Akira Naganuma & Gi-Wook Hwang
- Journal Title
  
  Scientific Reports
  
  Volume: 11
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H05493
[Journal Article] Gefitinib initiates sterile inflammation by pomoting IL-1β and HMGB1 release via two distinct mechanisms2021
- Author(s)
  Takuya Noguchi, Yuto Sekiguchi, Yuki Kudoh, Rio Naganuma, Tomohiro Kagi, Akiko Nishidate, Kazuhiro Maeda, Chizuru Ishii, Takashi Toyama, Yusuke Hirata, Gi-Wook Hwang, Atsushi Matsuzawa
- Journal Title
  
  Cell Death. Dis.
  
  Volume: 12 Issue: 1 Pages: 49-49
- DOI
  10.1038/s41419-020-03335-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07011, KAKENHI-PUBLICLY-19H05282, KAKENHI-PUBLICLY-20H05493, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-18K06622, KAKENHI-PROJECT-19K22481, KAKENHI-PROJECT-19K16345
[Journal Article] Identification of a novel endogenous long non-coding RNA that inhibits selenoprotein P translation2021
- Author(s)
  Mita Yuichiro、Uchida Risa、Yasuhara Sayuri、Kishi Kohei、Hoshi Takayuki、Matsuo Yoshitaka、Yokooji Tadashi、Shirakawa Yoshino、Toyama Takashi、Urano Yasuomi、Inada Toshifumi、Noguchi Noriko、Saito Yoshiro
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 49 Issue: 12 Pages: 6893-6907
- DOI
  10.1093/nar/gkab498
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07093, KAKENHI-PROJECT-19K11770, KAKENHI-PUBLICLY-20H05491, KAKENHI-PROJECT-21K19321, KAKENHI-PLANNED-21H05270, KAKENHI-PROJECT-20H00488
[Journal Article] Hydrogen Peroxide Causes Cell Death via Increased Transcription of HOXB13 in Human Lung Epithelial A549 Cells2020
- Author(s)
  Endo Naoki、Toyama Takashi、Naganuma Akira、Saito Yoshiro、Hwang Gi-Wook
- Journal Title
  
  Toxics
  
  Volume: 8 Issue: 4 Pages: 78-78
- DOI
  10.3390/toxics8040078
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H05493, KAKENHI-PROJECT-19K16345
[Journal Article] Increased putrescine levels due to ODC1 overexpression prevents mitochondrial dysfunction-related apoptosis induced by methylmercury2020
- Author(s)
  Sato Masayuki、Toyama Takashi、Kim Min-Seok、Lee Jin-Yong、Hoshi Takayuki、Miura Nobuhiko、Naganuma Akira、Hwang Gi-Wook
- Journal Title
  
  Life Sciences
  
  Volume: 256 Pages: 118031-118031
- DOI
  10.1016/j.lfs.2020.118031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05493, KAKENHI-PROJECT-19H04276, KAKENHI-PROJECT-19K16345
[Journal Article] The Nuclear Protein HOXB13 Enhances Methylmercury Toxicity by Inducing Oncostatin M and Promoting Its Binding to TNFR3 in Cultured Cells2019
- Author(s)
  Toyama Takashi、Xu Sidi、Nakano Ryo、Hasegawa Takashi、Endo Naoki、Takahashi Tsutomu、Lee Jin-Yong、Naganuma Akira、Hwang Gi-Wook
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 1 Pages: 45-45
- DOI
  10.3390/cells9010045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Induction of chemokine CCL3 by NF-κB reduces methylmercury toxicity in C17.2 mouse neural stem cells2019
- Author(s)
  Takahashi Tsutomu、Kim Min-Seok、Iwai-Shimada Miyuki、Hoshi Takayuki、Fujimura Masatake、Toyama Takashi、Fujiwara Yasuyuki、Naganuma Akira、Hwang Gi-Wook
- Journal Title
  
  Environmental Toxicology and Pharmacology
  
  Volume: 71 Pages: 103216-103216
- DOI
  10.1016/j.etap.2019.103216
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-19H04276
[Journal Article] Methylmercury causes neuronal cell death via M1-microglial activation in organotypic slices prepared from mouse cerebral cortex2019
- Author(s)
  Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 6 Issue: 5 Pages: 167-170
- DOI
  10.2131/fts.6.167
- NAID
  130007674519
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16345, KAKENHI-PROJECT-15H05714
[Journal Article] Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures2019
- Author(s)
  Hoshi T, Toyama T, Shinozaki Y, Koizumi S, Lee JY, Naganuma A, Hwang GW.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 44 Issue: 7 Pages: 471-479
- DOI
  10.2131/jts.44.471
- NAID
  130007674444
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06481, KAKENHI-PROJECT-19K16345, KAKENHI-PUBLICLY-18H05121, KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H04669, KAKENHI-PUBLICLY-19H04746
[Journal Article] Methylmercury induces the expression of chemokine CCL4 via SRF activation in C17.2 mouse neural stem cells2019
- Author(s)
  Min-Seok Kim, Tsutomu Takahashi, Jin-Yong Lee, Takashi Toyama, Takayuki Hoshi, Shusuke Kuge, Yasuyuki Fujiwara, Akira Naganuma, Gi-Wook Hwang
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 4631-4631
- DOI
  10.1038/s41598-019-41127-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961, KAKENHI-PROJECT-18K06630
[Journal Article] Chemokine CCL4 induced in mouse brain has a protective role against methylmercury toxicity2018
- Author(s)
  Tsutomu Takahashi, Min-Seok Kim, Miyuki Iwai-Shimada, Masatake Fujimura, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Journal Title
  
  Toxics
  
  Volume: 36 Issue: 3 Pages: 6-6
- DOI
  10.3390/toxics6030036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961
[Journal Article] Methylmercury induces cytotoxicity through inhibition of PTEN activity by a decrease in its solubility2018
- Author(s)
  Takumi Kobayashi, Takashi Toyama, Jin-Yong Lee, Nobuhiko Miura, Shunsuke Kuge, Akira Naganuma, Gi-Wook Hwang
- Journal Title
  
  BPB Reports
  
  Volume: 1 Pages: 1-15
- NAID
  130007938428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Activation of ornithine decarboxylase protects against methylmercury toxicity by increasing putrescine2018
- Author(s)
  Masayuki Sato, Takashi Toyama, Jin-Yong Lee, Nobuhiko Miura, Akira Naganuma, Gi-Wook Hwang
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 356 Pages: 120-126
- DOI
  10.1016/j.taap.2018.08.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714, KAKENHI-PROJECT-16H02961
[Journal Article] Methylmercury induces cytotoxicity through inhibition of PTEN activity by a decrease in its solubility2018
- Author(s)
  Kobayashi T., Toyama T., Lee J.Y., Miura N., Kuge S., Naganuma A., Hwang G.W.
- Journal Title
  
  BPB Rep.
  
  Volume: 1 Pages: 1-5
- NAID
  130007938428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02961
[Journal Article] Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells2017
- Author(s)
  Ihara Hideshi、Kasamatsu Shingo、Kitamura Atsushi、Nishimura Akira、Tsutsuki Hiroyasu、Ida Tomoaki、Ishizaki Kento、Toyama Takashi、Yoshida Eiko、Abdul Hamid Hisyam、Jung Minkyung、Matsunaga Tetsuro、Fujii Shigemoto、Sawa Tomohiro、Nishida Motohiro、Kumagai Yoshito、Akaike Takaaki
- Journal Title
  
  Chem. Res. Toxicol
  
  Volume: 30 Issue: 9 Pages: 1673-1684
- DOI
  10.1021/acs.chemrestox.7b00120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-17K19205, KAKENHI-PROJECT-17K15408, KAKENHI-PROJECT-17K15488, KAKENHI-PROJECT-17K17583, KAKENHI-PLANNED-26111008, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-15K08456, KAKENHI-PROJECT-16K13089, KAKENHI-PROJECT-16K15208, KAKENHI-PROJECT-15K20855, KAKENHI-PROJECT-15K20857, KAKENHI-PROJECT-15K20876, KAKENHI-PROJECT-16H05092
[Journal Article] TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice2017
- Author(s)
  Oda Sayaka、Numaga-Tomita Takuro、Kitajima Naoyuki、Toyama Takashi、Harada Eri、Shimauchi Tsukasa、Nishimura Akiyuki、Ishikawa Tatsuya、Kumagai Yoshito、Birnbaumer Lutz、Nishida Motohiro
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 7511-7511
- DOI
  10.1038/s41598-017-07903-4
- NAID
  120007128849
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0013, KAKENHI-PROJECT-17K15464, KAKENHI-PROJECT-17K15488, KAKENHI-PROJECT-17K15585, KAKENHI-PUBLICLY-16H01656, KAKENHI-PLANNED-26111011, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-16H05092
[Journal Article] Small interfering RNA-mediated knockdown of the transcription factor TCF3 enhances sensitivity to methylmercury in mouse neural stem cells2017
- Author(s)
  Takahashi , Wang Y, Toyama T, Kim M. S., Kuge S., Hwang G. W., Naganuma A
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 4 Issue: 2 Pages: 41-43
- DOI
  10.2131/fts.4.41
- NAID
  130005439338
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15488, KAKENHI-PROJECT-15H05714
[Journal Article] Methylmercury induces the expression of TNF-α selectively in the brain of mice2016
- Author(s)
  Iwai-Shimada M., Takahashi T., Kim M.S., Fujimura M. Ito H., Toyama T., Naganuma A. and Hwang G.W.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 38249-38249
- DOI
  10.1038/srep38294
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Metabolomic analysis of low molecular weight substances released into medium from HEK293 cells treated with methylmercury2015
- Author(s)
  Toyama T., Hwang G.W. and Naganuma A.
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 2 Issue: 5 Pages: 227-228
- DOI
  10.2131/fts.2.227
- NAID
  130005131079
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Methylmercury induces release of a cytotoxic factor from HEK293 cells into medium2015
- Author(s)
  Toyama T., Murakami S., Kuge S., Hwang G.W. and Naganuma A.
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 2 Issue: 5 Pages: 223-226
- DOI
  10.2131/fts.2.223
- NAID
  130005113420
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Journal Article] Citrulline enhances methylmercury toxicity in HEK293 and C17.2 cells2015
- Author(s)
  Toyama T., Hwang G.W. and Naganuma A.
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 2 Issue: 6 Pages: 229-231
- DOI
  10.2131/fts.2.229
- NAID
  130005131080
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05714
[Patent] COVID-19の治療剤2021
- Inventor(s)
  斎藤芳郎、外山喬士ら
- Industrial Property Rights Holder
  斎藤芳郎、外山喬士ら
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20H00488
[Patent] グリオブラストーマの治療薬のスクリーニング方法、治療薬、予後判定方法2021
- Inventor(s)
  斎藤芳郎、外山喬士、杉浦ひかり
- Industrial Property Rights Holder
  斎藤芳郎、外山喬士、杉浦ひかり
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-21K19321
[Patent] COVID-19治療剤2021
- Inventor(s)
  斎藤芳郎、外山喬士ら
- Industrial Property Rights Holder
  斎藤芳郎、外山喬士ら
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-21K19321
[Patent] セレノプロテインPを標的としたグリオブラストーマ治療薬2021
- Inventor(s)
  斎藤芳郎、外山喬士、杉浦ひかり
- Industrial Property Rights Holder
  斎藤芳郎、外山喬士、杉浦ひかり
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20H00488
[Patent] セレノプロテインPを標的としたグリオブラストーマ治療薬2020
- Inventor(s)
  斎藤芳郎、外山喬士、杉浦ひかり
- Industrial Property Rights Holder
  斎藤芳郎、外山喬士、杉浦ひかり
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-171561
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20H00488
[Presentation] Methylmercury suppresses cell proliferation through promoting the binding of oncostatin M and tumor necrosis factor receptor 32024
- Author(s)
  Toyama Takashi、Xu Sidi、Hasegawa Takashi、Naganuma Akira、Hwang Gi-Wook
- Organizer
  The Society of Toxicology 63rd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K25006
[Presentation] Elucidation of the molecular mechanisms involved in methylmercury toxicity caused by induction of OSM expression2023
- Author(s)
  Toyama Takashi、Xu Sidi、Hasegawa Takashi、Naganuma Akira、Hwang Gi-Wook
- Organizer
  The 10th International Congress of Asian Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K25006
[Presentation] A new aspect of selenoprotein P /ApoER2 pathway as a therapeutic target against glioblastoma2023
- Author(s)
  Takashi Toyama, Yoshiro Saito
- Organizer
  Japan/Korea Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K28236
[Presentation] セレノプロテインPを介したメチル水銀のリソソーム隔離に起因する解毒と障害2023
- Author(s)
  外山喬士、斎藤芳朗
- Organizer
  令和5年度メチル水銀研究ミーティング
- Data Source
  KAKENHI-PROJECT-23K28236
[Presentation] スルフォラファンによるNrf2非依存的なセレノプロテインP発現抑制機構2023
- Author(s)
  叶心瑩、外山喬士、斎藤芳郎
- Organizer
  日本毒性学会
- Data Source
  KAKENHI-PROJECT-23K28236
[Presentation] セレノプロテインPに対する付加体形成を介したセレン代謝の撹乱と制御2023
- Author(s)
  外山喬士、斎藤芳朗
- Organizer
  第1回付加体科学部会研究会
- Data Source
  KAKENHI-PROJECT-23K28236
[Presentation] Interaction between TNFR3 and oncostatin M in enhancing methylmercury toxicity2023
- Author(s)
  Toyama Takashi、Xu Sidi、Hasegawa Takashi、Naganuma Akira、Hwang Gi-Wook
- Organizer
  2023 Fall International Convention of The Pharmaceutical Society of Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K25006
[Presentation] 有害金属の解毒隔離代謝におけるSeP-リソソーム経路の新たな役割2023
- Author(s)
  外山喬士、斎藤芳朗
- Organizer
  若手が切り拓くオルガネラバイオロジー & トキシコロジーの新視点
- Invited
- Data Source
  KAKENHI-PROJECT-23K28236
[Presentation] メチル水銀の解毒代謝におけるグルタチオンと超硫黄の異なる役割2023
- Author(s)
  外山　喬士、工藤　琉那、斎藤　芳郎
- Organizer
  日本薬学会学術年会
- Data Source
  KAKENHI-PROJECT-21K19837
[Presentation] セレノプロテインP/ApoER2 経路による悪性膠芽腫増殖機構2023
- Author(s)
  外山喬士、鄭希、斎藤芳郎
- Organizer
  生命金属科学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K28236
[Presentation] Mechanism of methylmercury toxicity reduction by the transcription factor TCF32022
- Author(s)
  Ota Himeka、Matsushima Akari、Toyama Takashi、Naganuma Akira、Hwang Gi-Wook
- Organizer
  The 8th International Symposium on METALLOMICS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K25006
[Presentation] 細胞内セレン貯蔵における SeP/ApoER2 システム2022
- Author(s)
  市川　敦也、水野　彩子、外山　喬士、斎藤　芳郎
- Organizer
  メタルバイオサイエンス研究会2022
- Data Source
  KAKENHI-PROJECT-21K19837
[Presentation] メチル水銀がもたらすセレン利用撹乱機構と活性硫黄を利用した生体内防御機構2022
- Author(s)
  工藤　琉那、水野　彩子、外山　喬士、斉藤　芳郎
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19837
[Presentation] メチル水銀によるセレン代謝撹乱を防御する超硫黄の意義2022
- Author(s)
  外山　喬士
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K19837
[Presentation] 新規TNFR3結合蛋白質であるRPSAを介したメチル水銀毒性発現機構2021
- Author(s)
  角田洋平、外山喬士、進藤佐和子、菅原賢人、永沼章、黄基旭
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] TNF受容体3新規結合蛋白質の同定とメチル水銀による細胞死への関与2021
- Author(s)
  角田洋平、外山喬士、永沼章、斎藤芳郎、黄基旭
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] メチル水銀によるセレノプロテインP のSe-水銀化を介したセレン輸送機能撹乱2021
- Author(s)
  工藤　琉那、外山　喬士、斎藤　芳郎
- Organizer
  生命金属科学領域会議夏合宿
- Data Source
  KAKENHI-PUBLICLY-20H05493
[Presentation] メチル水銀によるセレノプロテインPのSe-水銀化に起因する生体影響2021
- Author(s)
  外山　喬士、工藤　琉那、斎藤　芳郎
- Organizer
  令和2年度メチル水銀研究ミーティング
- Data Source
  KAKENHI-PUBLICLY-20H05493
[Presentation] TCF3が示すメチル水銀毒性軽減作用へのスルフィレドキシンの関与2021
- Author(s)
  太田妃香、松島あかり、進藤佐和子、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2021
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] メチル水銀毒性軽減に関わる転写因子TCF3の下流因子の検索2021
- Author(s)
  太田妃香、松島あかり、進藤佐和子、外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] メチル水銀によるセレノプロテインP のSe-水銀化を介したセレン輸送機能撹乱2021
- Author(s)
  工藤　琉那、外山　喬士、斎藤　芳郎
- Organizer
  フォーラム2021　衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PUBLICLY-20H05493
[Presentation] 超硫黄分子によるSe-水銀化されたセレノプロテインPのターンオーバー2021
- Author(s)
  外山　喬士、工藤　琉那、斎藤　芳郎
- Organizer
  生理研研究会「生命を支える硫黄生物学の最前線」
- Data Source
  KAKENHI-PUBLICLY-20H05493
[Presentation] メチル水銀による炎症応答シグナルを介したオンコスタチンM発現誘導機構2021
- Author(s)
  星尚志、千葉冠太郎、外山喬士、永沼章、斎藤芳郎、黄基旭
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] セレノプロテインPのSe-水銀化を介したセレンホメオスタシスの撹乱2021
- Author(s)
  外山　喬士、工藤　琉那、斎藤　芳郎
- Organizer
  新学術領域領域会議　第1回地方巡業
- Data Source
  KAKENHI-PUBLICLY-20H05493
[Presentation] セレノプロテインＰによるリソソーム機能の調節機構2021
- Author(s)
  池田　峻也、外山　喬士、斎藤　芳郎
- Organizer
  メタルバイオサイエンス研究会2021
- Data Source
  KAKENHI-PROJECT-21K19837
[Presentation] ミクログリア細胞株におけるASK1/JNK/cJun経路を介したメチル水銀によるOSM発現誘導機構の解明2021
- Author(s)
  小松龍、千葉冠太郎、進藤佐和子、外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] ミクログリアにおけるメチル水銀によるMAPキナーゼを介したTNF-α発現誘導機構2020
- Author(s)
  外山喬士、星尚志、永沼章、斎藤芳郎、黄基旭
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] メチル水銀の炎症性サイトカイン類の発現誘導を介した脳神経傷害機構2020
- Author(s)
  外山　喬士
- Organizer
  フォーラム2020 環境・衛生トキシコロジー
- Invited
- Data Source
  KAKENHI-PROJECT-19K16345
[Presentation] S-水銀化から紐解くメチル水銀に対する生体応答2020
- Author(s)
  外山　喬士
- Organizer
  第2回医薬品開発研究センターシンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05493
[Presentation] Elucidation of the mechanism involved in the induction of chemokine CCL4 expression by methylmercury2020
- Author(s)
  Kim M.S., Takahashi T., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  59th Annual Meeting of the Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるセレノプロテインPのSe-水銀化：新たなSe-水銀化解析法で紐解くその生体影響2020
- Author(s)
  外山　喬士
- Organizer
  生命金属に関する合同年会 ConMetal2020
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05493
[Presentation] メチル水銀の炎症性サイトカイン類の発現誘導を介した脳神経傷害機構2020
- Author(s)
  外山　喬士
- Organizer
  フォーラム2020 環境・衛生トキシコロジー
- Invited
- Data Source
  KAKENHI-PUBLICLY-20H05493
[Presentation] A mechanism underlying methylmercury-induced TNF-α expression in mouse brain2020
- Author(s)
  Hoshi T., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  59th Annual Meeting of the Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] マウス脳内ミクログリアでのTNF-αの発現誘導はメチル水銀による神経細胞死に関与する2020
- Author(s)
  星尚志、外山喬士、永沼章、斎藤芳郎、黄基旭
- Organizer
  第59回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] メチル水銀はASK1/p38経路を回してミクログリアでのTNF-α発現を誘導する2020
- Author(s)
  星尚志、外山喬士、永沼章、斎藤芳郎、黄基旭
- Organizer
  メタルバイオサイエンス研究会2020
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] Redox regulation of microglial activation by methylmercury2020
- Author(s)
  Toyama T.
- Organizer
  Gordon Research Conference Oxygen Radicals
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるタンパク質のS-水銀化に起因する生体影響2020
- Author(s)
  外山　喬士
- Organizer
  日本薬学会第140年会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] ミクログリアでのメチル水銀によるp38を介したTNF-α発現誘導機構とそれによる神経細胞死2020
- Author(s)
  星尚志、外山喬士、永沼章、斎藤芳郎、黄基旭
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] メチル水銀によるマウス脳神経障害へのTNF受容体3の関与2020
- Author(s)
  角田洋平、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるASK1/p38経路を介したTNF-α発現誘導機構2020
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF受容体3を介したマウス脳神経細胞死へのオンコスタチンMの関与2020
- Author(s)
  角田洋平、星尚志、外山喬士、永沼章、斎藤芳郎、黄基旭
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] メチル水銀によるマウス脳神経障害へのTNF受容体3の関与2020
- Author(s)
  角田洋平、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] A mechanism underlying the enhancement of methylmercury toxicity through activation of transcription factor HOXB132020
- Author(s)
  Toyama T., Xu S., Nakano R., Hasegawa T., Naganuma A. and Hwang G.W.
- Organizer
  59th Annual Meeting of the Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] ミクログリアにおけるメチル水銀によるオンコスタチンM発現誘導機構2020
- Author(s)
  星尚志、外山喬士、永沼章、斎藤芳郎、黄基旭
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] RelB介したメチル水銀によるTNF-α発現誘導におけるtmRT1の役割2019
- Author(s)
  金子千華、外山喬士、永沼章、黄基旭
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Induction mechanism of TNF-α expression by methylmercury in microglial BV-2 cells2019
- Author(s)
  Hoshi T., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  The 39th Annual International Conference of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるマウス脳内でのオンコスタチンM産生細胞の同定とその発現誘導機構の解析2019
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるtmRT1/RelB経路を介したTNF-αの発現誘導2019
- Author(s)
  金子千華、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Involvement of TNF receptor 3 in the neuronal damage caused by methylmercury in mouse brain and its expected mechanisms2019
- Author(s)
  Yohei Tsunoda, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  2019 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] メチル水銀によるTNF受容体3を介した細胞死誘導機構の解明2019
- Author(s)
  角田洋平、外山喬士、星尚志、永沼章、黄基旭
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるミクログリアにおけるオンコスタチンMの発現誘導機構2019
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF受容体3を介したミトコンドリア機能障害2019
- Author(s)
  角田洋平、外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] Mechanisms involved in the induction of TNF-α expression by methylmercury in mouse brain2019
- Author(s)
  Takashi Toyama, Takayuki Hoshi, Akira Naganuma and Gi-Wook Hwang
- Organizer
  Society of Toxicology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Elucidation of the mechanisms involved in methylmercury toxicity enhancement showed by the novel transcription factor tmRT12019
- Author(s)
  Toyama T., Osaki K., Hwang G.W. and Naganuma A.
- Organizer
  The 39th Annual International Conference of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Improvement of organotypic slice culture of mouse cerebral cortex to evaluate M1-microglial activation2019
- Author(s)
  Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  Society of Toxicology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF受容体３を介した細胞死に関わる下流シグナル2019
- Author(s)
  角田洋平、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウス脳内でのTNF-α発現誘導に関わる細胞種の特定とその機構2019
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] 改良型マウス大脳皮質スライス培養を用いたミクログリアを介したメチル水銀毒性発現機構の検討2019
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Methylmercury causes neuronal cell death by impairing mitochondrial function via TNF receptor X2019
- Author(s)
  Toyama T., Tsunoda Y., Hoshi T., Naganuma A. and Hwang G.W.
- Organizer
  SfRBM 26th Annual Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるオンコスタチンM発現誘導機構2019
- Author(s)
  黄唯屹、外山喬士、永沼章、黄基旭
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀が示す神経細胞死誘導におけるTNF受容体3の関与2019
- Author(s)
  角田洋平、外山喬士、星尚志、永沼章、黄基旭
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] 転写因子RelBの活性化を介したメチル水銀によるTNF-α発現誘導機構2019
- Author(s)
  金子千華、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Establishment of organotypic brain slice culture that can evaluate M1-microglial activation2019
- Author(s)
  Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16345
[Presentation] メチル水銀毒性増強作用を示すオンコスタチンMの増加に関わる分子機構2019
- Author(s)
  市川貴之、外山喬士、長谷川貴、永沼章、黄基旭
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF受容体３を介した細胞死に関わる下流シグナル2019
- Author(s)
  角田洋平、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-19H04276
[Presentation] メチル水銀によるOSM蛋白質レベルの増加メカニズム2019
- Author(s)
  外山喬士、長谷川貴、永沼章、黄基旭
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀により神経幹細胞から放出される細胞増殖阻害因子の探索とその産生機構2019
- Author(s)
  外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Involvement of TNF receptor 3 in the neuronal damage caused by methylmercury in mouse brain and its expected mechanisms2019
- Author(s)
  Tsunoda Y., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  2019 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] マウス神経幹細胞におけるメチル水銀によるTNF受容体3を介した細胞死誘導機構2019
- Author(s)
  角田洋平、外山喬士、永沼章、黄基旭
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀毒性増強因子tmRT1を介したオンコスタチンMの発現誘導2019
- Author(s)
  外山喬士、黄唯迄、許思迪、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Establishment of organotypic brain slice culture that can evaluate M1-microglial activation2019
- Author(s)
  Hoshi T., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  2019 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF受容体3を介したミトコンドリア機能障害2019
- Author(s)
  角田洋平、外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるS-水銀化の毒性学2019
- Author(s)
  外山　喬士
- Organizer
  第46回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Redox Regulation of Microglial Activation by Methylmercury2019
- Author(s)
  Takashi Toyama
- Organizer
  Gordon Research Conference Oxygen Radicals
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16345
[Presentation] メチル水銀によるマウス脳神経障害へのTNF受容体3の関与2018
- Author(s)
  外山喬士、戸田英汰、永沼章、黄基旭
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-16H02961
[Presentation] Functional analysis of XRCC6, a tmRT1-binding protein in the tmRT1 activation by methylmercury2018
- Author(s)
  Yi-An Chen, Katsuhiro Osaki, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  ASIATOX 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるオンコスタチンM蛋白質の増加機構の解析2018
- Author(s)
  市川貴之、長谷川貴、外山喬士、永沼章、黄基旭
- Organizer
  第57会日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-16H02961
[Presentation] メチル水銀による傷害性ミクログリアへの活性化を介した神経細胞損傷2018
- Author(s)
  星　尚志、外山　喬士、永沼　章、黄　基旭
- Organizer
  フォーラム2018衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] A molecular mechanism for the induction of TNF-α expression by methylmercury in HEK293 cells2018
- Author(s)
  Chika Kaneko, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  ASIATOX 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるRelBを介したTNF-α発現誘導機構2018
- Author(s)
  金子千華、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] A novel mechanism involved in the induction of TNF-α expression by methylmercury2018
- Author(s)
  Chika Kaneko, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  2018 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of the cytotoxicity-inducing factors that are released from cells by methylmercury2018
- Author(s)
  Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  57th Annual Meeting of the Society of Toxicology, San Antonio, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀が示すマウス脳内での神経細胞死誘導作用へのTNF受容体3の関与2018
- Author(s)
  角田洋平、外山喬士、星尚志、永沼章、黄基旭
- Organizer
  第57会日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるオンコスタチンMとTNF受容体3との結合促進機構の解析2018
- Author(s)
  長谷川貴、許思迪、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるミクログリアでのTNF-α発現誘導機構2018
- Author(s)
  外山喬士、星尚志、永沼章、黄基旭
- Organizer
  第4回次世代を担う若手のためのレキュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of the Cytotoxicity-inducing Factors that are Released from Cells by Methylmercury2018
- Author(s)
  Takashi TOYAMA, Gi-Wook HWANG, Akira NAGANUMA
- Organizer
  Society of Toxicology 57th Annual Meeting and ToxExpo
- Data Source
  KAKENHI-PROJECT-17K15488
[Presentation] メチル水銀が示すマウス脳神経障害とTNF受容体3との関わり2018
- Author(s)
  角田洋平、外山喬士、星尚志、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Elucidation of mechanisms underlying induction of tumor necrosis factor-α by methylmercury in mouse brain2018
- Author(s)
  Murakami S., Toyama T., Hoshi N., Naganuma A. and Hwang G.W
- Organizer
  57th Annual Meeting of the Society of Toxicology, San Antonio, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるオンコスタチンM蛋白質の増加機構の解析2018
- Author(s)
  市川貴之、長谷川貴、外山喬士、永沼章、黄基旭
- Organizer
  第57会日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀が示す神経毒性への傷害性ミクログリアの関与2018
- Author(s)
  星尚志、外山喬士、篠崎陽一、小泉修一、永沼章、黄基旭
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀毒性増強に関わるtmRT1と結合する核内蛋白質の同定2018
- Author(s)
  陳奕安、秋山直行、大崎勝弘、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] A mechanism involved in the induction of oncostatin M expression by methylmercury2018
- Author(s)
  Wei Yi Huang, Takashi Toyama, Takayuki Hoshi, Akira Naganuma, Gi-Wook Hwang
- Organizer
  2018 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02961
[Presentation] RIP1キナーゼを介したtmRT1のメチル水銀毒性増強作用2018
- Author(s)
  外山喬士、松田健人、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウス脳内でのオンコスタチンM発現誘導機構の解明2018
- Author(s)
  黄　唯屹、外山　喬士、永沼　章、黄　基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF-α発現誘導に関わる新規メカニズム2018
- Author(s)
  金子千華、外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2018衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Methylmercury induced neuronal cell death via M1-microglia activation2018
- Author(s)
  Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  2018 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] A mechanism involved in the induction of oncostatin M expression by methylmercury2018
- Author(s)
  Wei Yi Huang, Takashi Toyama, Takayuki Hoshi, Akira Naganuma, Gi-Wook Hwang
- Organizer
  2018 Japan/Korea Joint Symposium on Pharmaceutical Health Science and Environmental Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるオンコスタチンM蛋白質の増加機構の解析2018
- Author(s)
  市川貴之、長谷川貴、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるミクログリアでのTNF-α発現誘導機構2018
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  第4回次世代を担う若手のためのレキュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Roles of the binding proteins of tmRT1, a novel transcription factor that involved in enhancement of methylmercury toxicity, in tmRT1 activation by methylmercury2018
- Author(s)
  Chen Y.A., Osaki K., Togashi Y., Toyama T., Hwang G.W. and Naganuma A.
- Organizer
  57th Annual Meeting of the Society of Toxicology, San Antonio, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] TNF受容体3を介したメチル水銀によるマウス脳神経傷害作用2018
- Author(s)
  角田洋平、外山喬士、星尚志、永沼章、黄基旭
- Organizer
  フォーラム2018衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるシステイン残基の修飾を介したtmRT1の活性化機構2018
- Author(s)
  二見叔亮、外山喬士、永沼章、黄基旭
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] マウスの脳内でのメチル水銀によるTNF-α発現誘導機構の解析2018
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  第57会日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF-αの発現誘導に関わる転写因子の同定2018
- Author(s)
  金子千華、外山喬士、野口拓也、松沢厚、永沼章、黄基旭
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるマウス脳神経障害へのTNF受容体3の関与2018
- Author(s)
  外山喬士、戸田英汰、永沼章、黄基旭
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] 大脳スライス培養系を用いたメチル水銀による神経傷害へのミクログリアの関与2018
- Author(s)
  星尚志、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会 2018
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of cells involved in the induction of tumor necrosis factor-α expression by methylmercury in the mouse brain and its molecular mechanisms2018
- Author(s)
  Takayuki Hoshi, Takashi Toyama, Akira Naganuma, Gi-Wook Hwang
- Organizer
  2018 ISES-ISEE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] tmRT1が示すメチル水銀毒性増強作用におけるRIP1の関与2018
- Author(s)
  外山喬士、松田健人、永沼章、黄基旭
- Organizer
  フォーラム2018衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] 新規転写因子tmRT1の活性化によるメチル水銀毒性増強作用におけるXRCC6の役割2017
- Author(s)
  黄基旭、陳奕安、大崎勝弘、外山喬士、永沼章
- Organizer
  メタルバイオサイエンス研究会2017
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀毒性増強に関わる転写因子tmRT1と結合する蛋白質の同定2017
- Author(s)
  冨樫佑太、大崎勝弘、陳奕安、外山喬士、永沼章、黄基旭
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] オンコスタチンMによるメチル水銀の細胞毒性増強に関わる分子機構2017
- Author(s)
  永沼章、許思迪、外山喬士、黄基旭
- Organizer
  メタルバイオサイエンス研究会2017
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of a cytotoxic factor released from cells treated with methylmercury2017
- Author(s)
  Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] The role of XRCC6 in activation of tmRT1 induced by methylmercury in HEK293 cells2017
- Author(s)
  Chen Y.A., Osaki K., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウスの脳内でのTNF-α発現誘導に関わる責任細胞の同定とその機構解析2017
- Author(s)
  星尚志、外山喬士、村上聡一、永沼章、黄基旭
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF-α発現誘導に関わるTNF-αプロモーター領域の解析2017
- Author(s)
  金子千華、外山喬士、黄基旭、永沼章
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Analysis of tumor necrosis factor-α expression induced by methylmercury in mouse brain2017
- Author(s)
  Hoshi T., Toyama T., Murakami S., Naganuma A. and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるアポトーシス誘導における転写因子TCF3の役割2017
- Author(s)
  外山喬士、王妍コウ、永沼章、黄基旭
- Organizer
  第56回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀毒性の増強に関わる転写因子 tmRT1と結合する蛋白質の探索とその役割の解明2017
- Author(s)
  陳奕安、大崎勝弘、外山喬士、黄基旭、永沼章
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of the binding proteins of tmRT1, a novel transcription factor, involved in enhancement of methylmercury toxicity2017
- Author(s)
  Togashi Y., Osaki K., Chen Y. A., Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウス脳内で活性化される転写因子の同定とその活性化機構2017
- Author(s)
  外山喬士、王妍コウ、金ミンソク、永沼章、黄基旭
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-16H02961
[Presentation] メチル水銀によるミクログリア細胞でのTNF-α発現誘導機構2017
- Author(s)
  黄基旭、村上聡一、外山喬士、永沼章
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of a cytotoxic factor released from cells treated with methylmercury2017
- Author(s)
  Toyama T., Naganuma A. and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02961
[Presentation] メチル水銀により活性化される転写因子の同定およびその役割2017
- Author(s)
  王妍コウ、外山喬士、金ミンソク、黄基旭、永沼章
- Organizer
  日本薬学会第137回年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Role of oncostatin M in methylmercury toxicity2017
- Author(s)
  Toda E., Xu S., Toyama T., Naganuma A., and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によって活性化される新規転写因子tmRT1の結合蛋白質の解析2017
- Author(s)
  外山喬士、陳奕安、冨樫佑汰、大崎勝弘、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2017
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] オンコスタチンMによるメチル水銀の細胞毒性増強に関わる分子機構2017
- Author(s)
  永沼章、許思迪、外山喬士、黄基旭
- Organizer
  メタロバイオサイエンス研究会2017
- Data Source
  KAKENHI-PROJECT-16H02961
[Presentation] メチル水銀投与マウス脳内でのTNF-α発現誘導機構2017
- Author(s)
  星尚志、外山喬士、村上聡一、永沼章、黄基旭
- Organizer
  第56回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] A mechanism for methylmercury induction of TNF-α in human TLR4-expressing HEK293 cells2017
- Author(s)
  Kaneko C., Toyama T., Fukagawa S., Noguchi T., Matsuzawa A., Naganuma A. and Hwang G.W.
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens, Incheon, Korea
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウス脳内で活性化される転写因子の同定とその活性化機構2017
- Author(s)
  外山喬士、王妍コウ、金ミンソク、永沼章、黄基旭
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of the cytotoxic factor released from cells treated with methylmercury2017
- Author(s)
  Takashi Toyama, Akira Naganuma and Gi-Wook Hwang
- Organizer
  The 12th International Conference and 5th Asian Congress on Environmental Mutagens
- Data Source
  KAKENHI-PROJECT-17K15488
[Presentation] メチル水銀によるTNF-α発現誘導に関わる新規転写因子tmRT1の機能解析2017
- Author(s)
  遠藤直紀、小杉健太、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2017
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] tmRT1が示すメチル水銀毒性増強作用におけるアポトーシスの関与2017
- Author(s)
  松田健人、外山喬士、永沼章、黄基旭
- Organizer
  メタルバイオサイエンス研究会2017
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀によるTNF-αの発現誘導機構2017
- Author(s)
  金子千華、外山喬士、深川隼、野口拓也、松沢厚、永沼章、黄基旭
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀投与マウス脳内でのTNF-α発現誘導およびその機構2017
- Author(s)
  外山喬士、村上聡一、黄基旭、永沼章
- Organizer
  日本薬学会第137回年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] Identification of the cytotoxic factor which is released from HEK293 cells treated with methylmercury2016
- Author(s)
  Takashi Toyama, Soichi Murakami, Gi-Wook Hwang, Akira Naganuma
- Organizer
  Japan/Korea Joint Symposium on Pharmaceutical Health Sciences and Environmental Toxicology
- Place of Presentation
  Tokyo
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] オートファジー誘導へのメチル水銀の関与とその機構解析2016
- Author(s)
  外山喬士、長谷川貴、松田健人、黄基旭、永沼章
- Organizer
  平成28年度メチル水銀研究ミーティング
- Place of Presentation
  Tokyo
- Year and Date
  2016-12-26
- Invited
- Data Source
  KAKENHI-PROJECT-15H05714
[Presentation] メチル水銀により細胞外へ放出されてメチル水銀毒性を増強する因子の探索2016
- Author(s)
  外山喬士 , 村上聡一 , 小杉健太 , 黄基旭 , 永沼章
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  名古屋
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-15H05714

1. HWANG Gi-Wook (00344680)

# of Collaborated Projects: 5 results

# of Collaborated Products: 119 results
2. Saito Yoshiro (70357060)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. 有澤琴子 (00813122)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. TAKAHASHI TSUTOMU (00400474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAGANUMA AKIRA (80155952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 91 results
6. 進藤佐和子 (50795987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 金子尚志 (20907993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 三田雄一郎 (70609122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 堤良平 (50435872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 種村健太郎 (20332322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山縣涼太 (20963424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Nishimura Akiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. URANO Yasuomi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 西田基宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 藤井重元

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 金光祥臣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 平田祐介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TOYAMA TAKASHI 外山 喬士

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A New Aspect of Selenoprotein P as Sequestration Factor against heavy metalsPrincipal Investigator

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Lysosomal redox control via hepatic-brain crosstalk and its disruption by methylmercuryPrincipal Investigator

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Disruption of redox status via an essential-metal and harmful-metal interactionPrincipal Investigator

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Methylmercury induced neuronal damage via M1-microglial activationPrincipal Investigator

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Cytostatic factor that released from methylmercury exposed cellsPrincipal Investigator

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[Book] セレンによる超硫黄分子ターンオーバー2021

TOYAMA TAKASHI 外山喬士

[Book] 特集微量元素欠乏 (亜鉛セレン等) と疾患2021