OHASHI Yoshimi 大橋愛美

… Alternative Names

Ohashi Yoshimi 大橋愛美

Less

Researcher Number	50727427
Other IDs
Affiliation (Current)	2025: 公益財団法人がん研究会, がん化学療法センター分子薬理部, 研究助手
Affiliation (based on the past Project Information) *help	2023: 公益財団法人がん研究会, がん化学療法センター分子薬理部, 研究助手 2016 – 2022: 公益財団法人がん研究会, がん化学療法センター分子薬理部, 主任研究助手
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor therapeutics Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator 低分子阻害薬 / サイクリン依存性キナーゼ / 分子標的薬 / 細胞死 / 転写調節 / RNAポリメラーゼII / 細胞周期停止 / サイクリン依存性キナーぜ / 分子標的治療 / 発現制御 … More / 蛋白質 / 癌 / Arf1 / ゴルジ体 … More Except Principal Investigator 遺伝子異常 / インフォマティクス / 薬剤反応性 / 合成致死 / 脆弱性 / がん依存性マップ / 分子標的 / ケミカルバイオロジー / 新規標的分子 / アンメットニーズ / データベース / 分子標的治療薬 / がん脆弱性遺伝子 / 機能ゲノミクス / ケミカルジェネティクス Less

転写調節型CDK阻害剤が著効を示すがんの層別化を可能とする抗がん分子機序の解明Principal Investigator
- Principal Investigator
  
  大橋愛美
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Development of innovative cancer therapy using novel CDK inhibitors that exhibit highly cell-specific anticancer effectsPrincipal Investigator
- Principal Investigator
  
  OHASHI Yoshimi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Identification of cell surface/secreted proteins that affect antitumor activity upon treatment with a Golgi-disruptor, M-COPAPrincipal Investigator
- Principal Investigator
  
  Ohashi Yoshimi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Japanese Foundation for Cancer Research
Screening of molecular target for cancer therapy by using chemical genetics and functional genomics
- Principal Investigator
  
  DAN shingo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Japanese Foundation for Cancer Research

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors2017
- Author(s)
  Yoshimi Ohashi, Mutsumi Okamura, Ryohei Katayama, Siyang Fang, Saki Tsutsui, Akinobu Akatsuka, Mingde Shan, Hyeong-Wook Choi, Naoya Fujita, Kentaro Yoshimatsu, Isamu Shiina, Takao Yamori, and Shingo Dan
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 2 Pages: 1641-1655
- DOI
  10.18632/oncotarget.22895
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06324, KAKENHI-PROJECT-16H05105, KAKENHI-PROJECT-17K07230, KAKENHI-PROJECT-17H03024
[Journal Article] Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles.2017
- Author(s)
  Benabdi S, Peurois F, Nawrotek A, Chikireddy J, Caneque T, Yamori T, Shiina I, Ohashi Y, Dan S, Rodriguez R, Cherfils J, Zeghouf M.
- Journal Title
  
  Biochemistry (Mosc)
  
  Volume: 56(38) Issue: 38 Pages: 5125-5133
- DOI
  10.1021/acs.biochem.7b00706
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07230, KAKENHI-PROJECT-16H05105
[Journal Article] M-COPA, a Golgi disruptor, inhibits cell surface expression of MET protein and exhibits antitumor activity against MET-addicted cancers.2016
- Author(s)
  Ohashi Y, Okamura M, Hirosawa A, Akatsuka A, Shiina I, Yoshimatsu K, Yamori T, Dan S.
- Journal Title
  
  Cancer Res
  
  Volume: in press Issue: 13 Pages: 3895-3903
- DOI
  10.1158/0008-5472.can-15-2220
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830120, KAKENHI-PROJECT-16H05105
[Journal Article] M-COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin.2016
- Author(s)
  Hattori T, Watanabe-Takahashi M, Shiina I, Ohashi Y, Dan S, Nishikawa K, Yamori T, Naito M.
- Journal Title
  
  Genes Cells.
  
  Volume: 21(8) Issue: 8 Pages: 901-906
- DOI
  10.1111/gtc.12386
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05105, KAKENHI-PROJECT-15K08040
[Presentation] 細胞選択的な抗がん活性を示す新規CDK阻害剤Azalamellarin 4の作用機序に関する解析.2023
- Author(s)
  大橋愛美, 福田勉, 岡村睦美, 西谷直之, 旦慎吾
- Organizer
  第27回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06622
[Presentation] Analysis of antitumor mechanism by a pan-CDK inhibitor Azalam 4, a novel synthetic derivative of lamellarin：pan-CDK2022
- Author(s)
  大橋愛美, 福田勉, 岡村睦美, 西谷直之, 岩尾正倫, 旦慎吾
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07626
[Presentation] 高い抗がん選択性を持つ新規合成ラメラリン類縁体Azalam 4の抗がん作用様式の解析.2021
- Author(s)
  大橋愛美, 福田勉, 岡村睦美, 岩尾正倫, 旦慎吾
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07626
[Presentation] Selective induction of apoptosis by a pan-CDK inhibitor Azalam 4, a novel synthetic derivative of lamellarin2021
- Author(s)
  大橋愛美, 福田勉, 岡村睦美, 西谷直之, 岩尾正倫, 旦慎吾
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07626
[Presentation] Antitumor mechanisms of Azalam 4, a novel synthetic lamellarin derivative, with potent antitumor selectivity2020
- Author(s)
  大橋愛美, 福田勉, 岡村睦美, 西谷直之, 岩尾正倫, 旦慎吾
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07626
[Presentation] 強い抗がん特異性を示し CDK を阻害する新規ラメラリン類縁体 Azalam4 の同定2020
- Author(s)
  大橋愛美, 福田勉, 岡村睦美, 西谷直之, 岩尾正倫, 旦慎吾
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07626
[Presentation] スフェロイド培養下におけるゴルジ体阻害剤M-COPAによる抗がん効果2019
- Author(s)
  大橋愛美、岡村睦美、赤塚明宣、椎名勇、旦慎吾
- Organizer
  第23回　日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] Potential antitumor effects of a Golgi disrupting agent, M-COPA, via targeting cell-extracellular matrix interaction under the spheroid culture conditions2019
- Author(s)
  大橋愛美、武内一真、岡村睦美、赤塚明宣、椎名勇、吉松賢太郎、旦慎吾
- Organizer
  2019AACR Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] Identification of a lung adenocarcinoma cell line addicted to ERBB4, an actionable target for cancer therapy2019
- Author(s)
  田中伯享、山崎佳波、宇野佑子、大橋愛美、西村由美子、澤匡明、旦慎吾
- Organizer
  2019AACR Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] ゲフィチニブ感受性を起点としたErbB4依存性肺がん細胞株及びその増殖阻害薬の同定2019
- Author(s)
  田中伯享、山崎佳波、宇野佑子、大橋愛美、西村由美子、澤匡明、旦慎吾
- Organizer
  2018年度新学術領域研究学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] Identification of ERBB4 as an actionable target by using selective anticancer effect of EGFR family tyrosine kinase inhibitors2019
- Author(s)
  田中伯享、山崎佳波、宇野佑子、大橋愛美、西村由美子、澤匡明、旦慎吾
- Organizer
  第11回（2019年）日米がん合同会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] ゲフィチニブ感受性を起点としたErbB4依存性肺がん細胞株及びその増殖阻害薬の同定2019
- Author(s)
  田中伯享、山崎佳波、宇野佑子、大橋愛美、西村由美子、澤匡明、旦慎吾
- Organizer
  2018年度新学術領域研究学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] スフェロイド培養下におけるゴルジ体阻害剤M-COPAによる抗がん効果2019
- Author(s)
  大橋愛美、岡村睦美、赤塚明宣、椎名勇、旦慎吾
- Organizer
  第23回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] Identification of ERBB4 as an actionable target by using selective anticancer effect of EGFR family tyrosine kinase inhibitors2019
- Author(s)
  田中伯享、山崎佳波、宇野佑子、大橋愛美、西村由美子、澤匡明、旦慎吾
- Organizer
  第11回（2019年）日米がん合同会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] Potential antitumor effects of a Golgi disrupting agent, M-COPA, via targeting cell-extracellular matrix interaction under the spheroid culture conditions2019
- Author(s)
  大橋愛美、武内一真、岡村睦美、赤塚明宣、椎名勇、吉松賢太郎、旦慎吾
- Organizer
  2019 AACR Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] 新規ゴルジ体阻害剤M-COPAに対する獲得耐性機構の解析2018
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、旦慎吾
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ体阻害剤M-COPAに対する獲得耐性機構の解析2018
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、旦慎吾
- Organizer
  第22回　日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] HER4依存性細胞株におけるHERファミリーチロシンキナーゼ阻害剤の抗がん効果2018
- Author(s)
  田中伯享、山崎佳波、大橋愛美、西村由美子、旦慎吾
- Organizer
  第77回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] スフェロイド培養下におけるゴルジ体阻害阻害剤M-COPAによる抗がん効果2018
- Author(s)
  大橋愛美、武内一真、岡村睦美、赤塚明宣、椎名勇、吉松賢太郎、旦慎吾
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] スフェロイド培養下におけるゴルジ体阻害阻害剤M-COPAによる抗がん効果2018
- Author(s)
  大橋愛美、武内一真、岡村睦美、赤塚明宣、椎名勇、吉松賢太郎、旦慎吾
- Organizer
  第77回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] ErbB4に依存した増殖を示す肺がん細胞株とその治療薬の同定2018
- Author(s)
  田中伯享、大橋愛美、旦慎吾
- Organizer
  第22回　日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] HER4依存性細胞株におけるHERファミリーチロシンキナーゼ阻害剤の抗がん効果2018
- Author(s)
  田中伯享、山崎佳波、大橋愛美、西村由美子、旦慎吾
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] ErbB4に依存した増殖を示す肺がん細胞株とその治療薬の同定2018
- Author(s)
  田中伯享、大橋愛美、旦慎吾
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ体阻害剤M-COPAが抗腫瘍効果を示すがん細胞の探索2017
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第21回　日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ阻害剤M-COPAのEGFR阻害剤耐性肺がんに対する抗がん効果2017
- Author(s)
  大橋愛美、岡村睦美、片山量平、赤塚明宣、藤田直也、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ阻害剤M-COPAのEGFR阻害剤耐性肺がんに対する抗がん効果2017
- Author(s)
  大橋愛美、岡村睦美、片山量平、赤塚明宣、藤田直也、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] 新規ゴルジ阻害剤M-COPAのEGFR-TKI耐性がんに対する抗がん効果2017
- Author(s)
  大橋愛美、岡村睦美、片山量平、赤塚明宣、藤田直也、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第21回　日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ体阻害剤M-COPAが抗腫瘍効果を示すがん細胞の探索2017
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第21回　日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] 新規ゴルジ阻害剤M-COPAのEGFR-TKI耐性がんに対する抗がん効果2017
- Author(s)
  大橋愛美、岡村睦美、片山量平、赤塚明宣、藤田直也、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第21回　日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K07230
[Presentation] 新規抗がん物質M-COPAの三次元培養下における抗がん効果2017
- Author(s)
  筒井咲妃、大橋愛美、岡村睦美、赤塚明宣、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] ゴルジ阻害剤M-COPAのin vivo抗がん作用におけるERストレスシグナルの関与2016
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第75回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ阻害剤M-COPAの抗がん作用メカニズムに対するERストレスの関与2016
- Author(s)
  赤塚明宣、岡村睦美、大橋愛美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第20回　日本がん分子標的治療学会
- Place of Presentation
  別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ体阻害剤M-COPAの細胞表面タンパク質発現に与える影響2016
- Author(s)
  方偲央、大橋愛美、赤塚明宣、吉松賢太郎、椎名勇、矢守隆夫
- Organizer
  第75回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ体阻害剤M-COPAの受容体チロシンキナーゼにアディクトしたがんへの抗がん効果2016
- Author(s)
  大橋愛美、岡村睦美、方偲央、玉城尚美、赤塚明宣、吉松賢太郎、椎名勇、矢守隆夫、旦慎吾
- Organizer
  第75回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] 新規ゴルジ阻害剤M-COPAのRTK依存がんに対する抗がん効果2016
- Author(s)
  大橋愛美、赤塚明宣、岡村睦美、椎名勇、吉松賢太郎、矢守隆夫、旦慎吾
- Organizer
  第20回　日本がん分子標的治療学会
- Place of Presentation
  別府
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H05105
[Presentation] M-COPA, a new Golgi disruptor, inhibited growth of RTK-addicted human cancer cells2016
- Author(s)
  大橋愛美、岡村睦美、方偲央、筒井咲妃、玉城尚美、赤塚明宣、吉松賢太郎、椎名勇、矢守隆夫、旦慎吾
- Organizer
  28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  ドイツ・ミュンヘン
- Year and Date
  2016-11-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05105

1. DAN shingo (70332202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
2. 田中伯享 (30815882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 赤塚明宣 (30649364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
4. MATSUURA masaaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. USHIJIMA masaru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 藤田直也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHASHI Yoshimi 大橋 愛美

Ohashi Yoshimi 大橋 愛美

Research Projects

Research Products

Co-Researchers

転写調節型CDK阻害剤が著効を示すがんの層別化を可能とする抗がん分子機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative cancer therapy using novel CDK inhibitors that exhibit highly cell-specific anticancer effectsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of cell surface/secreted proteins that affect antitumor activity upon treatment with a Golgi-disruptor, M-COPAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Screening of molecular target for cancer therapy by using chemical genetics and functional genomics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] M-COPA, a Golgi disruptor, inhibits cell surface expression of MET protein and exhibits antitumor activity against MET-addicted cancers.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] M-COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 細胞選択的な抗がん活性を示す新規CDK阻害剤Azalamellarin 4の作用機序に関する解析.2023

Author(s)

Organizer

Data Source

[Presentation] Analysis of antitumor mechanism by a pan-CDK inhibitor Azalam 4, a novel synthetic derivative of lamellarin：pan-CDK2022

Author(s)

Organizer

Data Source

[Presentation] 高い抗がん選択性を持つ新規合成ラメラリン類縁体Azalam 4の抗がん作用様式の解析.2021

Author(s)

Organizer

Data Source

[Presentation] Selective induction of apoptosis by a pan-CDK inhibitor Azalam 4, a novel synthetic derivative of lamellarin2021

Author(s)

Organizer

Data Source

[Presentation] Antitumor mechanisms of Azalam 4, a novel synthetic lamellarin derivative, with potent antitumor selectivity2020

Author(s)

Organizer

Data Source

[Presentation] 強い抗がん特異性を示し CDK を阻害する新規ラメラリン類縁体 Azalam4 の同定2020

Author(s)

Organizer

Data Source

[Presentation] スフェロイド培養下におけるゴルジ体阻害剤M-COPAによる抗がん効果2019

Author(s)

Organizer

Data Source

[Presentation] Potential antitumor effects of a Golgi disrupting agent, M-COPA, via targeting cell-extracellular matrix interaction under the spheroid culture conditions2019

Author(s)

Organizer

OHASHI Yoshimi 大橋愛美

Ohashi Yoshimi 大橋愛美