Koyama Daisuke 小山大輔

Researcher Number	50741071
Other IDs
Affiliation (Current)	2025: 福島県立医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 福島県立医科大学, 医学部, 講師 2019 – 2021: 自治医科大学, 医学部, 講師 2015 – 2018: 自治医科大学, 医学部, 客員研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator オートファジー / 慢性骨髄性白血病 / AMPK / 細胞内代謝 / 白血病 / クライオ電子顕微鏡 / FIP200 / ULK2 / BCR-ABL / mTOR … More / p53 / ｍTOR / トランスレーショナルリサーチ / 血液内科 / Sp1 / hsa-miR-155 / プロテアソーム阻害剤 / マイクロRNA / 薬剤耐性 / T-ALL / bortezomib / miR-155 … More Except Principal Investigator CD82 Less

アスタチンー211標識ヒト・キメラCD82抗体による難治白血病に対する治療法の開発
- Principal Investigator
  
  池添隆之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Fukushima Medical University
Structural basis of intracellular metabolic regulation in leukemiaPrincipal Investigator
- Principal Investigator
  
  小山大輔
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Fukushima Medical University
Development of CML eradicative therapy by regulating BCR-ABL subcellular localizationPrincipal Investigator
- Principal Investigator
  
  Koyama Daisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Jichi Medical University
The strategy for targeting Sp1 to eludicate CML cellsPrincipal Investigator
- Principal Investigator
  
  Koyama Daisuke
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
The mechanism of drug resistance regulated by miR-155 in T-ALLPrincipal Investigator
- Principal Investigator
  
  Koyama Daisuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University

All 2024 2023 2022 2021 2020 2019 2018 2015

All Journal Article Presentation

[Journal Article] High Efficacy and Safety of Asciminib in a Chronic Myeloid Leukemia Patient with Chronic Kidney Disease Following Renal Transplantation2024
- Author(s)
  Uchida Yasuhiro、Koyama Daisuke、Manabe Kazuya、Suzuki Kengo、Asano Naomi、Endo Mamiko、Fukatsu Masahiko、Sano Takahiro、Hayashi Kiyohito、Takano Motoki、Takahashi Hiroshi、Kimura Satoshi、Ikezoe Takayuki
- Journal Title
  
  Intern. Med.
  
  Volume: 63 Issue: 5 Pages: 717-720
- DOI
  10.2169/internalmedicine.2179-23
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2024-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08514
[Journal Article] Lymphoplasmacytic lymphoma presenting cold agglutinin syndrome: Clonal expansion of <i>KMT2D</i> and <i>IGHV4‐34</i> mutations after <scp>COVID</scp>‐192023
- Author(s)
  Hayashi Kiyohito、Koyama Daisuke、Sato Yuki、Fukatsu Masahiko、Ikezoe Takayuki
- Journal Title
  
  British Journal of Haematology
  
  Volume: 203 Issue: 5
- DOI
  10.1111/bjh.19106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08514
[Journal Article] Prognostic Value of Hematogones in Patients With Hematopoietic Disorders After Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis2023
- Author(s)
  Mori Hirotaka、Koyama Daisuke、Sato Yuki、Kataoka Yuki、Taito Shunsuke、Ishio Takashi、Teshima Takanori、Yokota Isao
- Journal Title
  
  Cureus
  
  Volume: 15
- DOI
  10.7759/cureus.47184
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K17712, KAKENHI-PROJECT-22K08514
[Journal Article] A case of cold agglutinin syndrome associated with chronic lymphocytic leukaemia harbouring mutations in CARD11 and KMT2D2023
- Author(s)
  Fukatsu Masahiko、Hamazaki Yoichi、Sato Yuki、Koyama Daisuke、Ikezoe Takayuki
- Journal Title
  
  International Journal of Hematology
  
  Volume: 118 Issue: 4 Pages: 472-476
- DOI
  10.1007/s12185-023-03608-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08514
[Journal Article] Successful allogeneic hematopoietic stem cell transplantation for myelodysplastic neoplasms complicated with secondary pulmonary alveolar proteinosis and Beh?et's disease harboring GATA2 mutation2023
- Author(s)
  Sato Yuki、Fukatsu Masahiko、Suzuki Tomohiro、Sasajima Tomomi、Gunji Naohiko、Yoshida Shuhei、Asano Naomi、Fukuchi Koichiro、Mori Hirotaka、Takano Motoki、Hayashi Kiyohito、Takahashi Hiroshi、Shirado-Harada Kayo、Kimura Satoshi、Koyama Daisuke、Migita Kiyoshi、Ikezoe Takayuki
- Journal Title
  
  International Journal of Hematology
  
  Volume: 118 Issue: 5 Pages: 642-646
- DOI
  10.1007/s12185-023-03603-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08514
[Journal Article] Mutated ZRSR2 and CUL3 accelerate clonal evolution and confer venetoclax resistance via RAS signaling pathway in blastic plasmacytoid dendritic cell neoplasm2023
- Author(s)
  Fukuchi Koichiro、Koyama Daisuke、Takada Maki、Mori Hirotaka、Hayashi Kiyohito、Asano Naomi、Sato Yuki、Fukatsu Masahiko、Takano Motoki、Takahashi Hiroshi、Shirado-Harada Kayo、Kimura Satoshi、Yamamoto Toshiyuki、Ikezoe Takayuki
- Journal Title
  
  International Journal of Hematology
  
  Volume: 118 Issue: 4 Pages: 489-493
- DOI
  10.1007/s12185-023-03597-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08514
[Journal Article] Development of Acute Adult T-cell Leukemia Following PD-1 Blockade Therapy for Lung Cancer2022
- Author(s)
  Misawa Kyohei、Yasuda Hajime、Matsuda Hironari、Hara Munechika、Ochiai Tomonori、Koyama Daisuke、Takano Hina、Iwao Noriaki、Koike Michiaki
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 22 Pages: 3421-3424
- DOI
  10.2169/internalmedicine.9405-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-11-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08514
[Journal Article] Serum IgG and lymphocyte counts are useful for the early detection of infection in patients receiving bendamustine-rituximab therapy2022
- Author(s)
  Suzuki Manabu、Koyama Daisuke、Ikeda Shohei、Sukegawa Masumi、Teshirogi Mayumi、Misawa Kyohei、Tsunoda Saburo
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: 62 Issue: 2 Pages: 91-98
- DOI
  10.3960/jslrt.21031
- NAID
  130008159458
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08514
[Journal Article] Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination2022
- Author(s)
  Misawa Kyohei、Yasuda Hajime、Koyama Daisuke、Inano Tadaaki、Inoguchi Akemi、Shirasu Chinami、Takano Hina、Iwao Noriaki、Ando Miki、Koike Michiaki
- Journal Title
  
  eJHaem
  
  Volume: 3 Issue: 3 Pages: 992-995
- DOI
  10.1002/jha2.508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08514
[Journal Article] mTOR inhibitors sensitize multiple myeloma cells to venetoclax via IKZF3-and Blimp-1-mediated BCL-2 up-regulation2021
- Author(s)
  Naoki Osada, Jiro Kikuchi, Daisuke Koyama, Yoshiaki Kuroda, Hiroshi Yasui, Joel D Leverson, Yusuke Furukawa
- Journal Title
  
  Haematologica
  
  Volume: 106 Issue: 11 Pages: 3008-3013
- DOI
  10.3324/haematol.2021.278506
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08847, KAKENHI-PROJECT-20K08761
[Journal Article] Autophagic degradation of NOXA underlies stromal cell-mediated resistance to proteasome inhibitors in mantle cell lymphoma2021
- Author(s)
  Kuroda Y, Koyama D, Kikuchi J, Mori S, Ichinohe T, Furukawa Y.
- Journal Title
  
  Leukemia research
  
  Volume: 111 Pages: 106672-106672
- DOI
  10.1016/j.leukres.2021.106672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08847, KAKENHI-PROJECT-20K08761
[Journal Article] Femoral marrow MRI is a non-invasive, non-irradiated and useful tool for detecting bone marrow involvement in non-Hodgkin lymphoma2021
- Author(s)
  Ikeda Shohei、Tsunoda Saburo、Koyama Daisuke、Suzuki Manabu、Sukegawa Masumi、Misawa Kyohei、Hojo Hiroshi、Zhu Xin、Utano Kenichi、Ohta Masatsugu
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: 61 Issue: 2 Pages: 78-84
- DOI
  10.3960/jslrt.20054
- NAID
  130008049320
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08847
[Journal Article] MTX-HOPE is a low-dose salvage chemotherapy for aged patients with relapsed or refractory non-Hodgkin lymphoma2021
- Author(s)
  Suzuki Manabu、Tsunoda Saburo、Koyama Daisuke、Ikeda Shohei、Sukegawa Masumi、Hojo Hiroshi、Ohta Masatsugu
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: 61 Issue: 1 Pages: 22-28
- DOI
  10.3960/jslrt.20051
- NAID
  130008000087
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08847
[Journal Article] Bone marrow stromal cell-mediated degradation of CD20 leads to primary rituximab resistance in mantle cell lymphoma2020
- Author(s)
  Kuroda Yoshiaki、Yashima-Abo Akiko、Koyama Daisuke、Kikuchi Jiro、Mori Shigehisa、Ito Shigeki、Furukawa Yusuke
- Journal Title
  
  Leukemia
  
  Volume: in press Issue: 5 Pages: 1506-1510
- DOI
  10.1038/s41375-020-01035-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08847, KAKENHI-PROJECT-20K08761
[Journal Article] Soluble SLAMF7 Promotes the Growth of Myeloma Cells via Homophilic Interaction with Surface SLAMF7.2020
- Author(s)
  Kikuchi J, Hori M, Iha H, Toyama-Sorimachi N, Hagiwara S, Kuroda Y, Koyama D, Izumi T, Yasui H, Suzuki A, Furukawa Y.
- Journal Title
  
  Leukemia.
  
  Volume: 34 Issue: 1 Pages: 180-195
- DOI
  10.1038/s41375-019-0525-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08847, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-17K09938, KAKENHI-PROJECT-20K08761, KAKENHI-PLANNED-15H05903
[Journal Article] Serum Endocrine Fibroblast Growth Factors as Potential Biomarkers for Chronic Kidney Disease and Various Metabolic Dysfunctions in Aged Patients2020
- Author(s)
  Yamamoto S, Koyama D, Igarashi R, Maki T, Mizuno H, Furukawa Y, Kuro-o M.
- Journal Title
  
  Intern. Med.
  
  Volume: 59 Issue: 3 Pages: 345-355
- DOI
  10.2169/internalmedicine.3597-19
- NAID
  130007793843
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2020-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08847
[Journal Article] AMP‐activated protein kinase activation primes cytoplasmic translocation and autophagic degradation of the BCR‐ABL protein in CML cells2020
- Author(s)
  Koyama Daisuke、Kikuchi Jiro、Kuroda Yoshiaki、Ohta Masatsugu、Furukawa Yusuke
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 1 Pages: 194-204
- DOI
  10.1111/cas.14698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08847, KAKENHI-PROJECT-20K08761
[Journal Article] Eradication of central nervous system leukemia of T-cell origin with a brain-permeable LSD1 inhibitor.2019
- Author(s)
  Saito S, Kikuchi J, Koyama D, Sato S, Koyama H, Osada N, Kuroda Y, Akahane K, Inukai T, Umehara T, Furukawa Y.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 25 Issue: 5 Pages: 1601-1611
- DOI
  10.1158/1078-0432.ccr-18-0919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-17K16193, KAKENHI-PROJECT-17K09938
[Journal Article] Lysine-specific Demethylase 1 Accelerates Oncogenesis in p53 Heterozygous Mice via Transcriptional Repression of the Residual Trp53 Allele.2019
- Author(s)
  Wada, T, Kikuchi, J, Koyama, D, Honda, H, Furukawa, Y.
- Journal Title
  
  Leukemia Res. 2019; 82: 29-32.
  
  Volume: 82 Pages: 29-32
- DOI
  10.1016/j.leukres.2019.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08847, KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-17K09938
[Journal Article] Cell adhesion-induced phosphorylation and inactivation of EZH2 confer drug resistance to acute myeloid leukemia cells.2018
- Author(s)
  Kikuchi J, Kuroda Y, Koyama D, and Furukawa Y.
- Journal Title
  
  Int J Hematol
  
  Volume: 107 Issue: 3 Pages: 383-385
- DOI
  10.1007/s12185-017-2376-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-17K16193, KAKENHI-PROJECT-17K09938
[Journal Article] Myeloma Cells Are Activated in Bone Marrow Microenvironment by the　CD180/MD-1 Complex, Which Senses Lipopolysaccharide.2018
- Author(s)
  Kikuchi J, Kuroda Y, Koyama D, Osada N, Izumi T, Yasui H, Kawase T, Ichinohe T, Furukawa Y.
- Journal Title
  
  Cancer Research
  
  Volume: 78 Issue: 7 Pages: 1766-1778
- DOI
  10.1158/0008-5472.can-17-2446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16193, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-17K09938
[Journal Article] Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma.2015
- Author(s)
  Kikuchi J, Koyama D, Wada T, Izumi T, Hofgaad PO, Bogen B, Furukawa Y.
- Journal Title
  
  J Clin Invest
  
  Volume: 125 Issue: 12 Pages: 4375-4390
- DOI
  10.1172/jci80325
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461430, KAKENHI-PROJECT-15K19557
[Journal Article] Soluble aKlotho as a Candidate for the Biomarker of Aging.2015
- Author(s)
  Koyama, D., Sato, Y., Aizawa, M., Maki, T., Kurosawa, M., Kuro-o, M. and Furukawa, Y
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 467 Issue: 4 Pages: 1019-1025
- DOI
  10.1016/j.bbrc.2015.10.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19557
[Journal Article] Overexpression of the shortest isoform of histone demethylase LSD1 primes hematopoietic stem cells for malignant transformation.2015
- Author(s)
  Wada T, Koyama D, Kikuchi J, Honda H, Furukawa Y.
- Journal Title
  
  Blood
  
  Volume: 125 Issue: 24 Pages: 3731-3746
- DOI
  10.1182/blood-2014-11-610907
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461430, KAKENHI-PROJECT-15K19557, KAKENHI-PROJECT-26293227
[Presentation] Subcellular localization of BCR-ABL is regulated by AMPKα in response to ATP demand in CML cells2020
- Author(s)
  小山大輔
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-19K08847
[Presentation] Subcellular localization of BCR-ABL responds to ATP demand regulated by AMPKα in CML cells2019
- Author(s)
  小山大輔
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-19K08847

1. 池添隆之 (80294833)

# of Collaborated Projects: 1 results

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2. 川村文彦 (10757074)

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3. 高橋和弘 (20370257)

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4. 織内昇 (40292586)

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5. 西嶋剣一 (60364254)

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6. 南陽介 (60513752)

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7. 立花太郎 (80311752)

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8. 鷲山幸信 (80313675)

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9. 趙松吉 (80374239)

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10. 鬼頭勇輔 (80444305)

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11. 菊池次郎

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12. 横田勲

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Koyama Daisuke 小山 大輔

Research Projects

Research Products

Co-Researchers

アスタチンー211標識ヒト・キメラCD82抗体による難治白血病に対する治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural basis of intracellular metabolic regulation in leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of CML eradicative therapy by regulating BCR-ABL subcellular localizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The strategy for targeting Sp1 to eludicate CML cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of drug resistance regulated by miR-155 in T-ALLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] High Efficacy and Safety of Asciminib in a Chronic Myeloid Leukemia Patient with Chronic Kidney Disease Following Renal Transplantation2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Lymphoplasmacytic lymphoma presenting cold agglutinin syndrome: Clonal expansion of <i>KMT2D</i> and <i>IGHV4‐34</i> mutations after <scp>COVID</scp>‐192023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic Value of Hematogones in Patients With Hematopoietic Disorders After Allogeneic Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A case of cold agglutinin syndrome associated with chronic lymphocytic leukaemia harbouring mutations in CARD11 and KMT2D2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful allogeneic hematopoietic stem cell transplantation for myelodysplastic neoplasms complicated with secondary pulmonary alveolar proteinosis and Beh?et's disease harboring GATA2 mutation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutated ZRSR2 and CUL3 accelerate clonal evolution and confer venetoclax resistance via RAS signaling pathway in blastic plasmacytoid dendritic cell neoplasm2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of Acute Adult T-cell Leukemia Following PD-1 Blockade Therapy for Lung Cancer2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Serum IgG and lymphocyte counts are useful for the early detection of infection in patients receiving bendamustine-rituximab therapy2022

Author(s)

Journal Title

DOI

NAID

Koyama Daisuke 小山大輔