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Takahashi Kazuhiro  高橋 和弘

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… Alternative Names

TAKAHASHI Kazuhiro  高橋 和弘

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Researcher Number 20370257
Affiliation (Current) 2025: 福島県立医科大学, 公私立大学の部局等, 教授
2025: 秋田県立循環器・脳脊髄センター(研究所), その他部局等, 研究員
Affiliation (based on the past Project Information) *help 2020 – 2024: 福島県立医科大学, 公私立大学の部局等, 教授
2018 – 2023: 福島県立医科大学, 医学部, 教授
2018: 秋田県立循環器・脳脊髄センター(研究所), その他部局等, 研究員
2016 – 2018: 慶應義塾大学, 医学部(信濃町), 特任准教授
2016: 秋田県立脳血管研究センター(研究部門), その他部局等, 研究員 … More
2015: 慶應義塾大学, 医学部, 特任准教授
2015: 慶応義塾大学, 医学部, 特任准教授
2014: 独立行政法人理化学研究所, その他部局等, 上級研究員
2013: 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー
2012: 理化学研究所, 分子イメージング科学研究センター, ユニットリーダー
2010 – 2012: 独立行政法人理化学研究所, 分子イメージング科学研究センター, ユニットリーダー
2008 – 2011: The Institute of Physical and Chemical Research, イメージング基盤ユニット, ユニットリーダー
2007: The Institute of Physical and Chemical Research, 分子プローブ機能評価研究チーム, 副チームリーダー
2006: National Institute of Radiological Sciences, Molecular Imaging Center, Senior Researcher, 分子イメージング研究センター, 主任研究員
2005: 秋田県立脳血管研究センター(研究局), 放射線医学研究部, 主任研究員 Less
Review Section/Research Field
Principal Investigator
Radiation science / Basic Section 52040:Radiological sciences-related
Except Principal Investigator
Basic Section 52040:Radiological sciences-related / Radiation science / Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields
Keywords
Principal Investigator
PET / 生体分子 / 分子イメージング / 標識合成 / 放射線 / アポトーシス / 腫瘍 / 脳・神経 / Ga-68 colloid / 68Ga標識スズコロイド … More / 貪食能 / クッパー細胞 / Ga-68標識スズコロイド / [Ga-68]標識スズコロイド / [Ga-68]Ga標識スズコロイド / molecular imaging / apoptosis / radio-labeling / molecular Probe / radiology / cancer / bio-molecule / 分子認識 / radiophamaceuticals / radiopharmaceuticals / PKC / 脳神経 / シグナル伝達 / Bcl-xL … More
Except Principal Investigator
PET / アスタチン / 自動合成 / PSMA / 核医学治療薬剤 / プレターゲティング / ヒト化白血病モデルマウス / 白血病幹細胞 / アスタチン-211 / At-211 / RI内用療法 / α線 / 核医学治療 / フッ素-18 / 標識プローブ / 標識合成 / マイクロリアクター / 分子イメージング / マイクロドジメトリ / 固相合成 / 組織化学 / アルファ線 / マイクロジメトリ / ラジオセラノスティクス / セラノスティクス / 前立腺がん / プレターゲティング法 / アルファ線標的治療(TAT) / 白血病韓細胞 / アスタチン標識抗体 / CD82 / ドジメトリー / アビジン / ビオチン / アイソトープ治療 / 金ナノ粒子 / アルファ線ガン治療薬 / 腎臓 / radiotheranostics / 核医学イメージング / 核医学診断薬剤 / 核医学診断 / 濃縮法 / 標識反応 / PETプローブ / マイクロスケール合成 / OEF / CBF / brain / MRI / 脳血管障害 / 脳酸素摂取率 / 脳血流量 / O-15標識ガス / PET/MRI / 抗CD82抗体 / 急性骨髄性白血病 / α線放出核種 / アスタチン-211標識抗体 / 抗hCD82ヒト化キメラmAb / 急性白血病 / アルファ線標的治療 / CD82抗原 / Lu-177 / 標的RI治療 / がん幹細胞 / 標的アイソトープ治療 / CXCX4 / CXCR4 / アスタチン211 / 癌幹細胞 / 放射免疫療法 / 膵癌 / 211At / 放射線 / 標識赤血球 / 前臨床試験 / 脾臓 / 熱変性 / FDG / 赤血球 / 要電子放出断層撮像 / 熱変性FDG標識赤血球 / 脾組織 / blood pool imaging / 陽電子放出断層撮像 / FDG標識赤血球 / ペプチド・タンパク質標識 / 電極反応 / 放射性金属核種 / 標識技術 / ペプチド・抗体標識 / 電気化学的濃縮 / 放射性金属 / 様式プローブ / 放射性薬剤 / F-18 Less
  • Research Projects

    (19 results)
  • Research Products

    (48 results)
  • Co-Researchers

    (49 People)
  •  アスタチンー211標識ヒト・キメラCD82抗体による難治白血病に対する治療法の開発

    • Principal Investigator
      池添 隆之
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Fukushima Medical University
  •  薬物送達システムとα線放出核種を組み合わせた革新的な白血病治療法の開発

    • Principal Investigator
      趙 松吉
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Fukushima Medical University
  •  ラジオハロゲン元素を用いた前立腺がんに対するラジオセラノスティクス薬剤の開発

    • Principal Investigator
      上原 知也
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Chiba University
  •  Development of alpha-ray microdosimetry at the cellular level

    • Principal Investigator
      長谷川 功紀
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Fukushima Medical University
  •  アスタチン化学のフロンティア解明と医学とのシナジー

    • Principal Investigator
      高貝 慶隆
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields
    • Research Institution
      Fukushima University
  •  Development of an innovative leukemia therapy using alpha-particle-emitting nuclides targeting cancer stem cells

    • Principal Investigator
      ZHAO Songji
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Fukushima Medical University
  •  Evaluation of pathophysiology of occlusive cerebrovascular disease using PET/MRI

    • Principal Investigator
      伊藤 浩
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Fukushima Medical University
  •  Development of efficient microscale automated module for radiosynthesis of 18F-labeled probes

    • Principal Investigator
      Iwata Ren
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Tohoku University
  •  New design of radiotheranostic agents that reduce renal radioactivity

    • Principal Investigator
      Uehara Tomoya
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Chiba University
  •  Optimization of pretargeted alpha therapy for multiple types of cancer

    • Principal Investigator
      Washiyama Kohshin
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Fukushima Medical University
  •  Development of Ga-68-tin colloid for visualizing reticuloendothelial system and sentinel lymph node using positron emission tomographyPrincipal Investigator

    • Principal Investigator
      Takahashi Kazuhiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Fukushima Medical University
  •  18F-FDG-labeled red blood cell PET for blood pool imaging

    • Principal Investigator
      Nakahara Tadaki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      Keio University
  •  Development of alpha-particle therapy for pancreas cancer with stem cell-targeting 211At-labeled antibody

    • Principal Investigator
      Oriuchi Noboru
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Fukushima Medical University
  •  Electrochemical concentration of radiometals in the microspace and its application to labeling of peptid

    • Principal Investigator
      Iwata Ren
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Radiation science
    • Research Institution
      Tohoku University
  •  Development of a multipurpose microreactor system for preparation of 18F-labeled probes

    • Principal Investigator
      Iwata Ren
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Tohoku University
  •  Development of a total microreactor system for radiosynthesis of^<18>F-labeled PET probes

    • Principal Investigator
      IWATA Ren
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Tohoku University
  •  Basic study of PET imaging of PKC, a intracellular transduction enzymePrincipal Investigator

    • Principal Investigator
      TAKAHASHI Kazuhiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Study for Molecular imaging of Bcl-Xl ; an apoptosis inhibitorPrincipal Investigator

    • Principal Investigator
      TAKAHASHI Kazuhiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Preliminary study for molecular imaging of Bcl-xL as an anti-apoptotic protein.Principal Investigator

    • Principal Investigator
      TAKAHASHI Kazuhiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Radiation science
    • Research Institution
      National Institute of Radiological Sciences
      Research institute for Brain and Blood Vesseis Akita

All 2024 2023 2022 2021 2020 2019 2018 2017 2014 2011

All Journal Article Presentation

  • [Journal Article] Deep Learning-Driven Estimation of Centiloid Scales from Amyloid PET Images with 11C-PiB and 18F-Labeled Tracers in Alzheimer’s Disease2024

    • Author(s)
      Tensho Yamao, Kenta Miwa , Yuta Kaneko, Noriyuki Takahashi, Noriaki Miyaji, Koki Hasegawa , Kei Wagatsuma, Yuto Kamitaka, Hiroshi Ito and Hiroshi Matsuda
    • Journal Title

      brain sciences

      Volume: 14 Issue: 4 Pages: 406-406

    • DOI

      10.3390/brainsci14040406

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07649, KAKENHI-PROJECT-23K27554
  • [Journal Article] Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study2023

    • Author(s)
      Ito Hiroshi、Ibaraki Masanobu、Yamakuni Ryo、Hakozaki Motoharu、Ukon Naoyuki、Ishii Shiro、Fukushima Kenji、Kubo Hitoshi、Takahashi Kazuhiro
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 73 Issue: 1 Pages: 25-25

    • DOI

      10.1186/s12576-023-00880-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K15831, KAKENHI-PROJECT-20K08031
  • [Journal Article] Construction of a Phantom for Image Quality Evaluation in PET/MRI System2022

    • Author(s)
      Takahashi Yasuyuki、Nemoto Ayaka、Hosokawa Shota、Ito Hiroshi、Oriuchi Noboru
    • Journal Title

      Annals of Nuclear Cardiology

      Volume: 8 Issue: 1 Pages: 103-108

    • DOI

      10.17996/anc.22-00152

    • ISSN
      2189-3926, 2424-1741
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08031, KAKENHI-PROJECT-23K25240
  • [Journal Article] Evaluation of Effect of Ninjin'yoeito on Regional Brain Glucose Metabolism by 18F-FDG Autoradiography With Insulin Loading in Aged Mice2021

    • Author(s)
      Zhao Jingmin、Imai Ryota、Ukon Naoyuki、Shimoyama Saki、Tan Chengbo、Maejima Yuko、Omiya Yuji、Takahashi Kazuhiro、Nan Guangxian、Zhao Songji、Ito Hiroshi、Shimomura Kenju
    • Journal Title

      Frontiers in Nutrition

      Volume: 8 Pages: 657663-657663

    • DOI

      10.3389/fnut.2021.657663

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08031, KAKENHI-PROJECT-21K15831
  • [Journal Article] Evaluation of organ glucose metabolism by 18F-FDG accumulation with insulin loading in aged mice compared with young normal mice2021

    • Author(s)
      Zhao Jingmin、Tan Chengbo、Imai Ryota、Ukon Naoyuki、Shimoyama Saki、Maejima Yuko、Omiya Yuji、Takahashi Kazuhiro、Ito Hiroshi、Nan Guangxian、Zhao Songji、Shimomura Kenju
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 7421-7421

    • DOI

      10.1038/s41598-021-86825-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08031, KAKENHI-PROJECT-20K08865, KAKENHI-PROJECT-21K15831, KAKENHI-PROJECT-18K08483
  • [Journal Article] 68Ga- and 211At-Labeled RGD Peptides for Radiotheranostics with Multiradionuclides2021

    • Author(s)
      Ogawa K, Echigo H, Mishiro K, Hirata S, Washiyama K, Kitamura Y, Takahashi K, Shiba K, Kinuya S.
    • Journal Title

      Molecular Pharmaceutics

      Volume: 18(9) Issue: 9 Pages: 3553-3562

    • DOI

      10.1021/acs.molpharmaceut.1c00460

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03627, KAKENHI-PROJECT-19H03598, KAKENHI-PROJECT-20K08102, KAKENHI-PROJECT-23K21425
  • [Journal Article] Simulation of the distribution of astatine-211 solution dispersion in a lab room2021

    • Author(s)
      Kubo Hitoshi、Takahashi Kazuhiro、Shimoyama Saki、Zhao Songji、Ukon Naoyuki、Ito Hiroshi
    • Journal Title

      Nuclear Medicine Communications

      Volume: 42 Issue: 9 Pages: 1052-1059

    • DOI

      10.1097/mnm.0000000000001430

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08031, KAKENHI-PROJECT-21K15831
  • [Journal Article] Integrated PET/MRI scanner with oxygen-15 labeled gases for quantification of cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen2021

    • Author(s)
      Ito Hiroshi、Kubo Hitoshi、Takahashi Kazuhiro、Nishijima Ken-Ichi、Ukon Naoyuki、Nemoto Ayaka、Sugawara Shigeyasu、Yamakuni Ryo、Ibaraki Masanobu、Ishii Shiro
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 35 Issue: 4 Pages: 421-428

    • DOI

      10.1007/s12149-021-01578-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K08031, KAKENHI-PROJECT-21K15831
  • [Journal Article] Human dosimetry of free 211At and meta-[211At]astatobenzylguanidine (211At-MABG) estimated using preclinical biodistribution from normal mice2020

    • Author(s)
      Ukon Naoyuki、Zhao Songji、Washiyama Kohshin、Oriuchi Noboru、Tan Chengbo、Shimoyama Saki、Aoki Miho、Kubo Hitoshi、Takahashi Kazuhiro、Ito Hiroshi
    • Journal Title

      EJNMMI Physics

      Volume: 7 Issue: 1 Pages: 58-58

    • DOI

      10.1186/s40658-020-00326-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08031, KAKENHI-PROJECT-19H03605, KAKENHI-PROJECT-18K15556, KAKENHI-PROJECT-20H03627
  • [Journal Article] Development of 68Ga-labeled tin colloids for evaluating phagocytic function of Kupffer cells using preclinical PET imaging2020

    • Author(s)
      Matsusaka Yohji、Nakahara Tadaki、Takahashi Kazuhiro、Iwabuchi Yu、Nakamura Shoki、Jinzaki Masahiro
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 34 Issue: 11 Pages: 807-814

    • DOI

      10.1007/s12149-020-01505-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07689
  • [Journal Article] Possibility of cancer-stem-cell-targeted radioimmunotherapy for acute myelogenous leukemia using 211At-CXCR4 monoclonal antibody.2020

    • Author(s)
      Oriuchi N
    • Journal Title

      Sci. Rep.

      Volume: 10 Issue: 1 Pages: 6810-6810

    • DOI

      10.1038/s41598-020-63557-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H03548, KAKENHI-PROJECT-19K08180, KAKENHI-PROJECT-20K08031, KAKENHI-PROJECT-20K21582, KAKENHI-PROJECT-19H03605
  • [Journal Article] A randomised phase II trial of capecitabine plus cisplatin versus S-1 plus cisplatin as a first-line treatment for advanced gastric cancer: Capecitabine plus cisplatin ascertainment versus S-1 plus cisplatin randomised PII trial (XParTS II).2018

    • Author(s)
      Nishikawa K, Tsuburaya A, Yoshikawa T, Kobayashi M, Kawada J, Fukushima R, Matsui T, Tanabe K, Yamaguchi K, Yoshino S, et al
    • Journal Title

      Eur J Cancer

      Volume: 101 Pages: 220-228

    • DOI

      10.1016/j.ejca.2018.06.026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K10608, KAKENHI-PROJECT-16H05393
  • [Journal Article] Preclinical evaluation of heat-denatured [18F]FDG-labeled red blood cells for detecting splenic tissues with PET in rats2018

    • Author(s)
      2.Yohji Matsusaka, Kazuhiro Takahashi, Yu Iwabuchi, Yuji Ogata, Chiyoko Nishime, Mayumi Kajimura, Masahiro Jinzaki
    • Journal Title

      Nuclear Medicine and Biology

      Volume: 56 Pages: 26-30

    • DOI

      10.1016/j.nucmedbio.2017.09.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07066, KAKENHI-PROJECT-16K10362
  • [Journal Article] Prognostic impact of LAT1 and CD98 expression in cutaneous angiosarcoma.2017

    • Author(s)
      Shimizu A, Kaira K, Okubo Y, Utsumi D, Yasuda M, Tominaga H, Oriuchi N, Kanai Y, Takahashi K, Ishikawa O.
    • Journal Title

      Neoplasma

      Volume: 64 Issue: 02 Pages: 283-288

    • DOI

      10.4149/neo_2017_216

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461154, KAKENHI-PROJECT-26461895, KAKENHI-PROJECT-16H05393
  • [Journal Article] 18F-FDG-labelled red blood cell PET for blood-pool imaging: Preclinical evaluation in rats2017

    • Author(s)
      3.Matsusaka Y, Nakahara T, Takahashi K, Iwabuchi Y, Nishime C, Kajimura M, Jinzaki M
    • Journal Title

      EJNMMI Research (European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 19 Issue: 1

    • DOI

      10.1186/s13550-017-0266-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07066, KAKENHI-PROJECT-16K10362
  • [Journal Article] Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis.2014

    • Author(s)
      Kaneta T., Okamura N., Arai A., Takanami K., Furukawa K., Tashiro M., Furumoto S., Iwata R., Takahashi S., Arai H., Yanai K., Kudo Y.
    • Journal Title

      Jpn. J. Radiol.

      Volume: 32 Pages: 138-144

    • NAID

      50009030775

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293257
  • [Journal Article] A modified method of 3D-SSP analysis for amyloid PET imaging using [^<11>C]BF-2272011

    • Author(s)
      Kaneta T, Okamuia N, Minoshima S, Furukawa K, Tashiro M, Furumoto S, Iwata R, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H
    • Journal Title

      Ann Nucl Med.

      Volume: 25 Issue: 10 Pages: 643-649

    • DOI

      10.1007/s12149-011-0518-7

    • NAID

      10030233510

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590754, KAKENHI-PROJECT-22390228, KAKENHI-PROJECT-23390297
  • [Presentation] ネオペンチル標識基を用いたPSMA標的薬剤の211Atへの展開2023

    • Author(s)
      上原知也、山下知輝、安田雄大、平山瑞希、貝塚祐太、甘中健登、鈴木博元、高橋和弘
    • Organizer
      第63回日本核医学会総会
    • Data Source
      KAKENHI-PROJECT-23K27543
  • [Presentation] O-15標識ガスPET検査における脳循環代謝諸量の無採血定量法の開発2023

    • Author(s)
      伊藤 浩、茨木正信、山國 遼、右近直之、石井士朗、福島賢慈、久保 均、高橋和弘
    • Organizer
      第66回日本脳循環代謝学会学術集会
    • Data Source
      KAKENHI-PROJECT-20K08031
  • [Presentation] Development of Radio-halogen-labeled PSMA-targeting ligand with high in vivo stability2023

    • Author(s)
      Tomoki Yamashita, Mizuki Hirayama, Takahiro Yasuda, Uta Kaizuka, Kazuhiro Takahashi, Kento Kannaka, Hiroyuki Suzuki, Tomoya Uehara
    • Organizer
      The 25th International Symposium on Radiopharmaceutical Sciences
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27543
  • [Presentation] ネオペンチル型標識基を用いたPSMA標的α線治療薬剤の研究2023

    • Author(s)
      山下知輝、甘中健登、鈴木博元、貝塚祐太、安田雄大、平山瑞希、高橋和弘、上原知也
    • Organizer
      第6回日本核医学会分科会放射性薬品科学研究会/第22回放射性医薬品・画像診断薬研究会
    • Data Source
      KAKENHI-PROJECT-23K27543
  • [Presentation] Pretargeted alpha radioimmunotherapy for the treatment of gastric cancer using low-immunogenic mutated streptavidin and 211At labeled modified bis-iminobiotin2023

    • Author(s)
      Kohshin Washiyama, Toshifumi Tatsumi, Akira Sugiyama, Songji Zhao, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Taiki Joho, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      12th International Symposium on Targeted Alpha Therapy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] O-15標識ガス定常吸入法を用いた脳循環代謝諸量の無採血定量法の開発 -実測データによる検討-2023

    • Author(s)
      伊藤 浩、茨木正信、山國 遼、右近直之、石井士朗、福島賢慈、久保 均、高橋和弘
    • Organizer
      第63回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K08031
  • [Presentation] Regional differences in oxygen extraction fraction in human brain measured by integrated PET/MRI scanner with oxygen-15 labeled gases2022

    • Author(s)
      Ito H, Ibaraki M, Yamakuni R, Ishii S, Fukushima K, Ukon N, Takahashi K
    • Organizer
      SNMMI 2022 Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08031
  • [Presentation] Synthesis of an 211At labelled bis-iminobiotin derivativewith enhanced plasma stability2022

    • Author(s)
      Kohshin Washiyama, Toshifumi Tatsumi, Akira Sugiyama, Songji Zhao, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Taiki Joho, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      2022 JSNM Annual Meeting
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] O-15標識ガス定常吸入法を用いた脳循環代謝諸量の無採血定量法の開発 -理論とシミュレーション-2022

    • Author(s)
      伊藤 浩、茨木正信、山國 遼、末永博紀、菅原茂耕、石井士朗、福島賢慈、久保 均、右近直之、西嶋剣一、高橋和弘
    • Organizer
      第62回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K08031
  • [Presentation] Synthesis and evaluation of 211At-labeled bis-iminobiotin for pretargeted alpha radioimmunotherapy2022

    • Author(s)
      Kohshin Washiyama, Toshifumi Tatsumi, Akira Sugiyama, Songji Zhao, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Taiki Joho, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      2022 SNMMI Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] 新規イメージング技術を用いたα線放出核種の組織内局所線量評価の基礎検討2021

    • Author(s)
      右近 直之, 鷲山 幸信, 趙 松吉, 織内 昇, 西嶋 剣一, 城寳 大輝, 下山 彩希, 高橋 和弘, 伊藤 浩
    • Organizer
      第58回アイソトープ・放射線研究発表会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] 健常者における脳酸素摂取率(OEF)の脳内局所差について.2021

    • Author(s)
      伊藤 浩、茨木正信、山國 遼、箱﨑元晴、菅原茂耕、関野啓史、石井士朗、久保 均、右近直之、高橋和弘
    • Organizer
      第61回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K08031
  • [Presentation] Targeted delivery of 211At with low immunogenic mutant streptavidin-bisiminobiotin pre-targeting system2021

    • Author(s)
      Toshifumi Tatsumi, Kenzo Yamatsugu, Akira Sugiyama, Songji Zhao, Miho Aoki, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Chengbo Tan, Fengying Gao, Taiki Joho, Noboru Oriuchi, Kazuhiro Takahashi, Motomu Kanai, Tatsuhiko Kodama, Kohshin Washiyama
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] イミノビオチン誘導体の合成とアスタチン標識の検討2020

    • Author(s)
      粟生木美穂, 巽俊文, 西嶋剣一, 山次健三, 城寶大輝, 趙松吉, 杉山暁, 児玉龍彦, 高橋和弘, 金井求, 鷲山幸信
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] O-15標識ガスおよびPET/MRI装置を用いた脳循環代謝測定における減弱補正および体動補正の影響2020

    • Author(s)
      伊藤 浩、久保 均、高橋和弘、西嶋剣一、粟生木美穂、右近直之、根本彩香、茨木正信、山國 遼、菅原茂耕、石井士朗
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K08031
  • [Presentation] プレターゲティングへの応用を目指した211At標識改変イミノビオチンの体内分布測定2020

    • Author(s)
      鷲山幸信, 巽俊文, 杉山暁, 粟生木美穂, 譚成博, 下山彩希, 山次健三, 金井求, 児玉龍彦, 趙松吉, 高橋和弘
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] Development and preclinical PET imaging of 68Ga-tin colloid for visualization and quantification of the phagocytic function of Kupffer cells2020

    • Author(s)
      Yohji Matsusaka, Tadaki Nakahara, Kazuhiro Takahashi, Yu Iwabuchi, Masahiro Jinzaki
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging (SNMMI)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07689
  • [Presentation] Measurement of cerebral circulation and oxygen metabolism using integrated PET/MRI scanner with oxygen-15 labeled gases: Effects of attenuation correction and real-time motion correction2020

    • Author(s)
      Ito H, Kubo H, Takahashi K, Ishii S
    • Organizer
      SNMMI 2020 Annual Meeting
    • Data Source
      KAKENHI-PROJECT-20K08031
  • [Presentation] 進行癌におけるCupidと211At標識Psyche-Bを用いたプレターゲティング法の治療効果評価2020

    • Author(s)
      趙松吉, 右近直之, 織内昇, 高峰英, 下山彩希, 高橋和弘, 巽俊文, 山次健三, 金井求, 杉山暁, 児玉龍彦
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] Development of a pre-targeting strategy of low-immunogenic mutated streptavidin with 211At labeled modified biotin for advanced cancer treatment2020

    • Author(s)
      Kohshin Washiyama, Akira Sugiyama, Songji Zhao, Toshifumi Tatsumi, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Naoyuki Ukon, Saki Shimoyama, Chengbo Tan, Taiki Joho, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      SNMMI 2020 Annual Meeting - Virtual Edition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] Search for the optimal bis-iminobiotin for the pretargeting strategy using a mutated low immunogenic streptavidin2020

    • Author(s)
      K. Washiyama, T. Tatsumi, S. Zhao, A. Sugiyama, M. Aoki, K. Yamatsugu, N. Ukon, K. Nishijima, S. Shimoyama, C. Tan, T. Joho, N. Oriuchi, M. Kanai, K. Takahashi, T. Kodama
    • Organizer
      33th Annual Congress of the European Association of Nuclear Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] 211At標識イミノビオチンを用いたプリターゲティング法の最適化 投与間隔による薬物動態評価2020

    • Author(s)
      右近直之, 鷲山幸信, 杉山暁, 巽俊文, 山次健三, 下山彩希, 織内昇, 金井求, 児玉龍彦, 高橋和弘, 趙松吉
    • Organizer
      第60回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] Biodistribution and dosimetry studies for the optimization of pre-targeted radionuclide therapy using 211At-labeled modified biotin2020

    • Author(s)
      Kohshin Washiyama, Akira Sugiyama, Songji Zhao, Toshifumi Tatsumi, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Saki Shimoyama, Taiki Joho, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      33th Annual Congress of the European Association of Nuclear Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] α放射体211At標識イミノビオチンの作成と安定性評価2020

    • Author(s)
      鷲山幸信、粟生木美穂、巽俊文、山次健三、杉山暁、西嶋剣一、城寶大輝、高峰英、趙松吉、金井求、児玉龍彦、高橋和弘
    • Organizer
      日本放射化学会第64回討論会(2020)
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] 進行がん治療を指向した低免疫原性ストレプトアビジン変異体と 211At標識イミノビオチンを用いるプレターゲティングシステムの開発2020

    • Author(s)
      巽俊文, 山次健三, 清水洋平, 杉山暁, 趙松吉, 粟生木美穂, 西嶋剣一, 右近直之, 高橋和弘, 児玉龍彦, 鷲山幸信, 金井求
    • Organizer
      反応と合成の進歩2020特別企画シンポジウム|
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] α放射体211Atを用いたプレターゲティング法による進行がんの治療2020

    • Author(s)
      Kohshin Washiyama, Akira Sugiyama, Kenzo Yamatsugu, Songji Zhao, Toshifumi Tatsumi, Miho Aoki, Naoyuki Ukon, Saki Shimoyama, Ken-ichi Nishijima, Chengbo Tan, Taiki Joho, Fengying Gao, Noboru Oriuchi, Motomu Kanai, Kazuhiro Takahashi, Tatsuhiko Kodama
    • Organizer
      日本放射線影響学会第63回大会
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] Evaluation of therapeutic effect of the targeted alpha therapy using Cupid-211At-labeled Psyche-B pretargeting system in a human gastric cancer cell xenograft2020

    • Author(s)
      Songji Zhao, Akira Sugiyama, Naoyuki Ukon, Saki Shimoyama, Toshifumi Tatsumi, Miho Aoki, Fengying Gao, Kenzo Yamatsugu, Ken-ichi Nishijima, Taiki Joho, Noboru Oriuchi, Kazuhiro Takahashi, Motomu Kanai, Tatsuhiko Kodama, Kohshin Washiyama
    • Organizer
      33th Annual Congress of the European Association of Nuclear Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03627
  • [Presentation] Development and preclinical PET imaging of 68Ga-tin colloid for visualization and quantification of the phagocytic function of Kupffer cells2019

    • Author(s)
      Yohji Matsusaka, Kazuhiro Takahashi, Tadaki Nakahara, Masahiro Jinzaki.
    • Organizer
      SNMMI2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07689
  • [Presentation] Biodistribution of free 211At and meta-[211At]astatobenzylguanidine (MABG) in normal mice2018

    • Author(s)
      Songji Zhao, Miho Aoki, Kohshin Washiyama, Naoyuki Ukon, Chengbao Tan, Saki Shimoyama, Hitoshi Kubo, Noboru Oriuchi, Kazuhiro Takahashi, Hiroshi Ito, Seiichi Takenoshita
    • Organizer
      第58回日本核医学会総会
    • Data Source
      KAKENHI-PROJECT-16H05393
  • [Presentation] Targeted Alpha Therapy in Japan - Where we are in 2018-2018

    • Author(s)
      Oriuchi N, Washiyama K, Nishijima K, Aoki M, Zhao S, Ukon N, Takahashi K
    • Organizer
      EANM’19
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05393
  • [Presentation] 18F-FDG標識赤血球を用いたPETによるBlood Pool Imagingの前臨床研究2017

    • Author(s)
      松坂 陽至, 中原 理紀, 高橋 和弘
    • Organizer
      日本核医学会
    • Data Source
      KAKENHI-PROJECT-16K10362
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    # of Collaborated Projects: 6 results
    # of Collaborated Products: 16 results
  • 2.  ZHAO Songji (80374239)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 18 results
  • 3.  IWATA Ren (60143038)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 4.  Oriuchi Noboru (40292586)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 5.  右近 直之 (70792985)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 13 results
  • 6.  池添 隆之 (80294833)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  西嶋 剣一 (60364254)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  杉山 暁 (40562715)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 15 results
  • 9.  FURUMOTO Shozo (00375198)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 10.  SAIKI Hidekazu (70466382)
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
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    # of Collaborated Products: 10 results
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    # of Collaborated Products: 13 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  陣崎 雅弘 (80216259)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  大島 康宏 (00588676)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  伊藤 浩 (20360357)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 24.  小島 隆生 (50807469)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  石井 士朗 (90508813)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 26.  原田 龍一 (60735455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  高貝 慶隆 (70399773)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  山下 雄史 (50615622)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Products: 15 results
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    # of Collaborated Projects: 1 results
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  • 35.  鬼頭 勇輔 (80444305)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  山下 篤 (90372797)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 39.  長谷川 功紀 (50525798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  山本 誠一 (00290768)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  佐藤 達彦 (30354707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  城寳 大輝 (40848876)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
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    # of Collaborated Products: 2 results
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    # of Collaborated Products: 1 results
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    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 48.  福島 亮治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
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    # of Collaborated Products: 1 results

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