Uehara Tomoya 上原知也

… Alternative Names

Researcher Number	10323403
Other IDs
External Links
Affiliation (Current)	2020: 千葉大学, 大学院薬学研究院, 教授
Affiliation (based on the past Project Information) *help	2019 – 2020: 千葉大学, 大学院薬学研究院, 教授 2016 – 2018: 千葉大学, 大学院薬学研究院, 准教授 2012 – 2015: 千葉大学, 薬学研究科(研究院), 准教授 2012: 千葉大学, 大学院・薬学研究院, 准教授 2012: 千葉大学, 薬学研究院, 准教授 … More
Review Section/Research Field	Principal Investigator Radiation science / 医薬分子機能学 / Basic Section 52040:Radiological sciences-related Except Principal Investigator Radiation science / Radiation science / Digestive surgery / Medium-sized Section 15:Particle-, nuclear-, astro-physics, and related fields
Keywords	Principal Investigator SPECT / 内用放射線治療 / 放射性医薬品 / 治療効果判定 / PET / 腎臓 / 核医学治療 / 核移行性ペプチド / 蛋白質標識薬剤 / リソソーム代謝 … More Except Principal Investigator テクネチウム-99m / アイソトープ治療 / 腎障害 / 抗体 / 放射性ヨウ素 / 分子イメージング / 放射性レニウム / 内用放射線治療 / 抗腫瘍抗体 / 抗腫瘍ペプチド / ペプチド / 低分子化抗体 / 代謝性スペーサ / 刷子縁膜酵素 / 多価効果 / SPECT / センチネルリンパ節 / 癌 / 体内動態 / 放射性医薬品 / ビスフォスフォン酸 / 骨代謝機能 / 転移性骨腫瘍 / 疼痛緩和 / テクネチウム / 腎集積 / 腎臓刷子縁膜酵素 / カルボキシペプチダーゼM / 代謝開列性スペーサ / インジウム-111 / イットリウム-90 / インジウムーll1 / レニウム-186,188 / 代謝開烈性スペーサ / イットリム-90 / 混合配位子錯体 / 標識プローブ / 結合力 / 胃十二指腸外科学 / 外科 / 色素 / 分光解析 / 標識抗体 / 超高比放射能 / 極微量 / 抗体フラグメント / 腫瘍 / 造影剤 / 中性アミノ酸トランスポーター / ポリクリロナル抗体 / モノクロナル抗体 / 血液脳関門 / 腫瘍細胞 / 放射性標識抗体 / 人工アミノ酸 / トランスポーターイメージング / 比放射能 / キャリアタンパク質 / アポトーシス / 放射性医薬品・造影剤 / 腫瘍特異的代謝亢進 / 癌の内部照射治療 / ヨウ素標識薬剤 / 悪性黒色腫 / メラニン生合成 / チロシナーゼ / 含流アミン誘導体 / 含硫アミン誘導体 / 放射性ヨウ素標識薬剤 / メラニン形成 / ヨウ素標識アミノ酸 / Radioiodine / Radioipharmaceuticals / Internal radiation therapy / Metabolic activity / Melanoma / Melanin biosynthesis / Kinetics regulation / Serum protein binding / 腎臓 / 癌治療 / カルボキシペプチダーゼ / 腫瘍親和性ペプチド / 腫瘍内滞留性 / Radiotherapy / antibody fragment / radioiodine / kidney / brush border membrane / metabolizable linkage / peptides / 画像診断学 / 組織再構築 / 細胞外マトリクス / 遺伝子工学 / DIAGNOSTIC IMAGING / REMODELING / EXTRACELLUAR MATRIX / GENETIC ENGINEERING / ANTIBODY / 半導体型ガンマカメラ / マンノース結合分子 / 網内系細胞 / 網内系細胞親和性トレーサ / cancer / sentinel lymph node / semiconductor gamma camera / Mannose binding lectins / reticuloendothelial cells / 液体金属 / 合金 / 二重標識 / RI製造 / 放射性ハロゲン Less

腎放射活性を低減するradiotheranostic薬剤の新規設計Principal InvestigatorOngoing
- Principal Investigator
  
  上原知也
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Chiba University
液体合金標的で拓く有用RIの2核種同時製造・標識法の開発Ongoing
- Principal Investigator
  
  石岡典子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 15:Particle-, nuclear-, astro-physics, and related fields
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of radiotheranostics agent using Fab fragment of anti-regulatory T cellsPrincipal Investigator
- Principal Investigator
  
  Uehara Tomoya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
Development of highly-sensitive apoptosis imaging agent based on new drug design
- Principal Investigator
  
  Hanaoka Hirofumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Gunma University
Development of dual-modality SPECT/fluorescent probePrincipal Investigator
- Principal Investigator
  
  Uehara Tomoya
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
Engineering radiolabeled antibody fragments for enhanced tumor to kidney ratioPrincipal Investigator
- Principal Investigator
  
  Uehara Tomoya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
99mTc-labeled probes imitating antibodies
- Principal Investigator
  
  ARANO Yasushi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
Development of radiolabeled antibody for channel transporter imaging
- Principal Investigator
  
  SHIMAMOTO Naoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Ibaraki Prefectural University of Health Science
Design of ^<99m>Tc-labled compound for diagnosis of metastatic tumor in bonePrincipal Investigator
- Principal Investigator
  
  上原知也
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
がん集積の向上を目指す標識抗体の新規設計法
- Principal Investigator
  
  荒野泰
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
Near infrared imaging of indocyanine green for sentinel lymph node navigation using nano-sized particle
- Principal Investigator
  
  HAYASHI Hideki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
In vivo imaging of DNA repair for estimating the sensitivity of tumor to radiotherapyPrincipal Investigator
- Principal Investigator
  
  UEHARA Tomoya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
Chemical design of chelating agents suitable to radiotherapy using antibody fragments as vehicles
- Principal Investigator
  
  YASUSHI Arano
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
標的分子との高い結合力を有する多価テクネチウム標識薬剤の設計
- Principal Investigator
  
  荒野泰
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
エネルギー依存性アミノ酸輸送システム評価薬剤は癌治療効果の早期判定に有効かPrincipal Investigator
- Principal Investigator
  
  上原知也
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
DEMELOPMENT OF RAKIOLABELED SMALLER ANTI-TENASCIN-CANTIBODY FOR CLINICAL USE
- Principal Investigator
  
  IRIE Toshiaki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences
Sentinel lymph node mapping using 99m Tc-labeled mannosyl-neoglycoalbumin and small semiconductor gamma camera for gastrointestinal cancers.
- Principal Investigator
  
  HAYASHI Hideki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
アイソトープ治療の副作用低減と治療効果増強を目的とした金属RI標識ペプチドの設計
- Principal Investigator
  
  荒野泰
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
癌治療効果の早期判定を目的とする放射性薬剤の開発Principal Investigator
- Principal Investigator
  
  上原知也
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
Molecular design of radioiodinated peptides for targeted radiotherapy
- Principal Investigator
  
  ARANO Yasushi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
放射能の核移行を目的としたタンパク質標識試薬の開発Principal Investigator
- Principal Investigator
  
  上原知也
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Chiba University
骨代謝機能診断および転移性骨腫瘍の疼痛緩和を目的とする放射性薬剤の設計
- Principal Investigator
  
  YASUSHI Arano
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Chiba University
DEVELOPEMENT OF RADIOIODINATED RADIOPHARMACEUTICALS FOR INTERNAL RADIATION THERAPY OF TUMOR BASED ON ITS SPECIFIC METABOLIC ACTIVITY
- Principal Investigator
  
  KAWAI Keiichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Kanazawa University
  宮崎医科大学

[Book] Technetium-99m radiopharmaceuticals for monitoring drug resistance. In : Technetium-99m Radiopharmaceuticals : Status and Trends.2009
- Author(s)
  Akizawa H, Uehara T, Arano Y.
- Total Pages
  360
- Publisher
  Sales and promotion Section, International Atomic Energy Agency
- Data Source
  KAKENHI-PROJECT-20659186
[Book] Technetium-99m Radiopharmaceuticals for lymphoscintigraphy. In : Technetium-99m Radiopharmaceuticals : Status and Trends.2009
- Author(s)
  Uehara T, Akizawa H, Arano Y.
- Total Pages
  360
- Publisher
  Sales and promotion Section, International Atomic Energy Agency
- Data Source
  KAKENHI-PROJECT-20659186
[Journal Article] 67/68Ga-labeling Agent that Liberates 67/68Ga-NOTA-methionine by Lysosomal Proteolysiso of Parental Low Molecular Weight Polypeptides to Reduce Renal Radioactivity Levels2014
- Author(s)
  Tomoya Uehara, Takemi Rokugawa, Mai Kinoshita, Aouki Nemoto, Guerra Gomez Fransisco Lazaro, Hirofumi Hanaoka, and Yasushi Arano
- Journal Title
  
  Bioconjugate Chem.
  
  Volume: 25 Pages: 2038-2045
- DOI
  10.1021/bc5004058
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25713045
[Journal Article] γ-Glutamyl PAMAM dendrimer as versatile precursor for dendrimer-based targeting devices.2010
- Author(s)
  Uehara T, Ishii D, Uemura T, Suzuki H, Kanei T, et al.
- Journal Title
  
  Bioconjugate Chemistry 20
  
  Pages: 169-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659186
[Journal Article] Intracellular reactions affecting 2-amino-4-([^<11>C] methylthio) butyric acid ([^<11>C] methionine) response to carbon ion radiotherapy in C10 glioma cells.2009
- Author(s)
  Uehara T, Nakagawa M, Takai N, Koike S., et al.
- Journal Title
  
  Nuclear Medicine and Biology 36
  
  Pages: 985-991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659186
[Journal Article] Renal uptake and metabolism of radiopharma- ceuticals derived from peptides and proteins.2008
- Author(s)
  Akizawa H, Uehara T, Arano Y.
- Journal Title
  
  Adv. Drug Deliv. Review 60
  
  Pages: 1319-1328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Assessment of macrocyclic triamine ligands as syntons for organometallic 99mTc radiopharmaceuticals.2008
- Author(s)
  Suzuki K, Shimmura N, Thipyapong K, Uehara T, Akizawa H, Arano Y.
- Journal Title
  
  Inorg Chem 47
  
  Pages: 2593-2600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Assessment of macrocyclic triamine ligands as syntons for organo-metallic <99m>^Tc radiopharmaceuticals2008
- Author(s)
  K. Suzuki, N. SHimmura, T. Uehara, H. Akizawa, Y. Arano
- Journal Title
  
  Inorg Chem 47
  
  Pages: 2593-2600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Renal uptake and metabolism of radiopharmaceuticals Derived from peptides and proteins2008
- Author(s)
  Akizawa H, Uehara T, Arano Y.
- Journal Title
  
  Advanced Drug Delivery Reveiws 60
  
  Pages: 1319-1328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659186
[Journal Article] Assessment of macrocyclic triamine ligands as syntons for organometallic ^<99m>Tc radiopharmaceuticals2008
- Author(s)
  Suzuki K, Shimmura T, Thipyapong K, Uehara T, Akizawa H, Arano Y.
- Journal Title
  
  Inorg. Chem. 47
  
  Pages: 2593-2600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Assessment of macrocyclic triamine ligands as synthons for organometallic 99m Tcradiopharmaceuticals.2008
- Author(s)
  Suzuki K, Shimmura N, Thipyapong K, Uehara T, Akizawa H, Arano Y.
- Journal Title
  
  Inorg Chem 47
  
  Pages: 2593-2600
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390342
[Journal Article] Noninvasive detection of cardiac repair after acute myocardial infarction in rats by 111In-Fab fragment of monoclonal antibody specific for tenascin-C.2008
- Author(s)
  Odaka K, Uehara T, Arano Y, Adachi S, Tadokoro H, Yoshida K, Hasegawa H, I manaka-Yoshida K, Yoshida T, Hiroe M, Irie T, Komuro I.
- Journal Title
  
  Int. Heart Journal 49
  
  Pages: 481-492
- NAID
  130000069081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Assessment of macrocyclic triamine ligands as synthons for organometallic (99m)Tc radiopharmaceuticals.2008
- Author(s)
  Suzuki K, Shimmura N, Thipyapong K, Uehara T, Akizawa H, Arano Y.
- Journal Title
  
  Inorg Chem. 47
  
  Pages: 2593-600
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390342
[Journal Article] Assessment of macrocyclic triamine ligands as syntons for organo-metallic ^<99m>Tc radiopharmaceuticals2008
- Author(s)
  K. Suzuki, N. SHimmura, T. Uehara, H. Akizawa, Y. Arano
- Journal Title
  
  Inorg Chem 47
  
  Pages: 2593-2600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659342
[Journal Article] Noninvasive detection of cardiac repair after acute myo cardial infarction in rats by 111In?Fab fragment of mon oclonal antibody specific for tenascin-C.2008
- Author(s)
  Odaka K, Uehara T, Arano Y Adachi S, Yadokoro H, Yoshida K, Hasegawa H, I manaka-Yoshida K, Yoshida T, Hiroe M, Irie T, Tanada S, Komuro I.
- Journal Title
  
  International Heart Journal 49
  
  Pages: 481-492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659186
[Journal Article] Komuro I. Noninvasive detection of cardiac repair after acute myocardial infarction in rats by ^<111>In Fab fragment of monoclonal antibody specific for tenascin-C.2008
- Author(s)
  Odaka K, Uehara T, Arano Y, Adachi S, Tadokoro H, Yoshida K, Hasegawa H, Imanaka-Yoshida K, Yoshida T, Hiroe M, Irie T, Tanada S.
- Journal Title
  
  Int. Heart J. 49
  
  Pages: 481-492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Renal metabolism of radiopharmaceuticals derived from peptides and proteins2008
- Author(s)
  Akizawa H, Uehara T, Arano Y
- Journal Title
  
  Adv. Drug Deliv. Reviews 60
  
  Pages: 1319-1328
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Assessment of macrocyclic triamine ligands as synthons for organometalic(99m)Tc radiopharmaceuticals.2008
- Author(s)
  Suzuki K, Shimmura N, Thipyapong K, Uehara T, Aldzawa H, Arano Y.
- Journal Title
  
  Inorg Chem. 47
  
  Pages: 2593-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390342
[Journal Article] 臨床応用に向けたラジオアイソトープ標識坑テネイシンC低分子化抗体の開発 : 抗体2種類の同時静注による検討2007
- Author(s)
  小高謙一,上原知也,小林典裕,今中恭子,荒野泰,棚田修二,入江俊章
- Journal Title
  
  インナービジョン 22
  
  Pages: 21-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390342
[Journal Article] 臨床応用に向けたラジオアイソトープ標識坑テネイシンC低分子化抗体の開発:抗体2種類の同時静注による検討2007
- Author(s)
  小高謙一, 上原知也, 小林典裕, 今中恭子, 荒野泰, 棚田修二, 入江俊章
- Journal Title
  
  インナービジョン 22
  
  Pages: 21-21
- Data Source
  KAKENHI-PROJECT-17390342
[Journal Article] Technetium-99m-labeled long chain fatty acid analogues metabolized by beta-oxidation in the heart.2007
- Author(s)
  Uehara T, Uemura T, Hirabayashi S, Adachi S, Odaka K, Akizawa H, Magata Y, Irie T, Arano Y.
- Journal Title
  
  J Med Chem 50
  
  Pages: 543-549
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390342
[Journal Article] Technetium-99m-labeled long chain fatty acid analogs metabolized by β-oxidation in the heart.2007
- Author(s)
  T.Uehara, T.Uemura, S.Hirabayashi, S.Adachi, K.Odaka, H.Akizawa, Y.Magata, T.Irie, Y.Arano
- Journal Title
  
  Journal of Medicinal Chemistry 50(3)
  
  Pages: 543-249
- Data Source
  KAKENHI-PROJECT-18659342
[Journal Article] Development of radiolabeled smaller anti-tenascin-C antibody for clinical use : comparison between two antibodies by dual injection.2007
- Author(s)
  odaka K, Uehara T, Kobayashi N, Imanaka-Yoshida K, Arano Y, Tanada S, Irie T.
- Journal Title
  
  Innervision. 22
  
  Pages: 21-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390342
[Journal Article] Design, synthesis and evaluation of [^<186>Re]organorhenium-labeled antibody fragments with renal enzyme-cleavable linkage for low renal radioactivity levels.2007
- Author(s)
  T.Uehara, M.Koike, H.Nakata, H.Hanaoka, Y.Iida, K.Hashimoto, H.Akizawa, K.Endo, Y.Arano
- Journal Title
  
  Bioconjugate Chemistry 18(1)
  
  Pages: 190-198
- Data Source
  KAKENHI-PROJECT-18659342
[Journal Article] Assessment of ^186Re-chelate-conjegated bisphosphonate for the development of new rradiopharmaceuticals for bone.2007
- Author(s)
  T.Uehara, Z-L.Jin, K.Ogawa, H.Akizawa, K.Hashimoto, M.Nakayama, Y.Arano.
- Journal Title
  
  Nuclear Mesicine and Biology 34(1)
  
  Pages: 79-87
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Technetium-99m-labeled long fatty acid analogues metabolized by beta-oxidation in the heart.2007
- Author(s)
  Uehara T, Uemura T, Hirabayashi S, Adachi S, Odaka K, Akizawa H, Magata Y, Irie T, Arano Y.
- Journal Title
  
  J Med Chem. 50
  
  Pages: 543-9
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390342
[Journal Article] Techonetium-99m-labeled long chain fatty acid analogs metabolized by β-oxidation in the heart.2007
- Author(s)
  T.Uehara, T.Uemura, S.Hirabayashi, S.Adachi, K.Odaka, H.Akizawa, Y.Magata, T, Irie, Y.Arano.
- Journal Title
  
  Journal of Medicinal Chemistry 50(3)
  
  Pages: 543-249
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Design, synthesis and evaluation of [186Re]organorhenium-labeled antibody frag- ments with renal enzyme-cleavable linkage for low renal radioactivity levels2007
- Author(s)
  Uehara T, Koike M, Nakata H, Hanaoka H, K, Iida Y, Hashimoto K, Akizawa H, Endo K, Arano Y.
- Journal Title
  
  Bioconjugate Chem. 18
  
  Pages: 190-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Assessment of ^<186>Re-chelate-conjugated bisphosphonate for the development of new radiopharmaceuticals for bone.2007
- Author(s)
  T.Uehara, Z-L.Jin, K.Ogawa, H.Akizawa, K.Hashimoto, M.Nakayama, Y.Arano
- Journal Title
  
  Nuclear Medicine and Biology 34(1)
  
  Pages: 79-87
- Data Source
  KAKENHI-PROJECT-18659342
[Journal Article] Design, synthesis and evaluation of [^186Re]organorhenium-labeled antibody fragments with renal enzyme-cleavble linkage for low renal redioactivity levels.2007
- Author(s)
  T.Uehara, M.Koike, H.Nakata, H.Hanaoka, Y.Iida, K.Hashimoto, H.Akizawa, K.Endo, Y.Arano.
- Journal Title
  
  Bioconjugate Chemistry 18(1)
  
  Pages: 190-198
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Technetium-99m-labeled long chain fatty acid analogs metabolized by β-oxidation in the heart2007
- Author(s)
  Uehara T, Uemura T, Hirabayashi S, Adachi S, Odaka K, Akizawa H, Magata Y, Irie T, Arano Y.
- Journal Title
  
  J. Med. Chem. 50
  
  Pages: 543-549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Rhenium-186-monoamimnemonoamidedithiol-conjugated bisphosphonate derivatives for bone pain palliation.2006
- Author(s)
  K.Ogawa, T.Mukai, Y.Arano, A.Otaka, M.Ueda, T.Uehara, Y.Magata, K.Hashimoto, H.Saji
- Journal Title
  
  Nuclear Medicine and Biology 33(4)
  
  Pages: 513-520
- Data Source
  KAKENHI-PROJECT-18659342
[Journal Article] Rhejum-186-monoamimnemonoamidedithiol-conjugated bisphosphonate dervatives for bone pain palliation.2006
- Author(s)
  K.Ogawa, T.Mukai, Y.Arano, A.Otaka, M.Ueda, T.Uehara, Y.Magata., K.Hashimoto, H.Saji.
- Journal Title
  
  Nuclear Medicine and Biology 33(4)
  
  Pages: 513-520
- Data Source
  KAKENHI-PROJECT-18390328
[Journal Article] Application of radiopharmaceuticals for drug development : Estimation of pharmacokinetics by AMS and PET after microdose administration2005
- Author(s)
  Tomoya Uehara, Yasushi Arano
- Journal Title
  
  Folia Pharmacol.Jpn 126
  
  Pages: 129-134
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370270
[Journal Article] 医薬品開発における放射性薬剤の利用 : 極微量(microdose)投与後の薬物動態のAMSおよびPETによる評価2005
- Author(s)
  上原知也, 荒野泰
- Journal Title
  
  日本薬理学会誌 126
  
  Pages: 129-134
- NAID
  10019596398
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370270
[Patent] 放射性標識薬剤2016
- Inventor(s)
  荒野泰　上原知也
- Industrial Property Rights Holder
  荒野泰　上原知也
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-038836
- Filing Date
  2016-03-01
- Data Source
  KAKENHI-PROJECT-25713045
[Patent] 核医学診断装置の制御方法、核医学診断装置、診断剤キット、および標識抗テネイシンCscFvフラグメント2012
- Inventor(s)
  小高謙一、入江俊章、福村利光、田所裕之、小室一成、荒野泰、上原知也、秋澤宏行、小林典裕、吉田利通、吉田恭子、廣江道昭
- Industrial Property Rights Holder
  独立行政法人放射線医学総合研究所、国立大学法人千葉大学、小林典弘、国立大学法人三重大学、独立行政法人国立国際医療研究センター
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-102732
- Filing Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-17390342
[Patent] 放射性標識化合物2009
- Inventor(s)
  荒野泰, 上原知也
- Filing Date
  2009-04-28
- Overseas
- Data Source
  KAKENHI-PROJECT-18390328
[Patent] 放射性標識薬剤2008
- Inventor(s)
  荒野泰、上原知也
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Number
  2008-278563
- Filing Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20659186
[Patent] 放射性標識薬剤2008
- Inventor(s)
  荒野泰、上原知也
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Number
  2008-278563
- Filing Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-18390328
[Patent] 放射性標識化合物2008
- Inventor(s)
  荒野泰, 上原知也
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Number
  2008-278563
- Filing Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-18390328
[Patent] 放射性標識薬剤2007
- Inventor(s)
  荒野泰, 上原知也
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Filing Date
  2007-10-29
- Data Source
  KAKENHI-PROJECT-18390328
[Patent] Radioactive metal-cyclopentadieny carbonyl derivatives for disease diagnosis and treatment.2003
- Inventor(s)
  Arano Y., Uehara T., et al.
- Industrial Property Rights Holder
  日本メジフィジックス(株)
- Filing Date
  2003-07-30
- Acquisition Date
  2005-02-24
- Data Source
  KAKENHI-PROJECT-14370270
[Patent] Radioactive metal-cyclopentadieny carbonyl derivatives for disease diagnosis and treatment.2003
- Inventor(s)
  Arano Y., Uehara T., et al.
- Industrial Property Rights Holder
  日本メジフィジックス(株)
- Filing Date
  2003-07-30
- Acquisition Date
  2005-02-24
- Data Source
  KAKENHI-PROJECT-15659277
[Presentation] 腎放射活性の低減に刷子縁膜酵素を利用した抗体フラグメント標識薬剤のCu-64への応用2019
- Author(s)
  喜瀬翔太、上原知也、小林まどか、鈴木博元、荒野泰
- Organizer
  第3回日本核医学会分科会放射性医薬品科学研究会
- Data Source
  KAKENHI-PROJECT-17H04258
[Presentation] 放射性ガリウム標識抗体フラグメントの非特異的腎集積を低減させる標識薬剤の開発2016
- Author(s)
  上原知也、横山幹、鈴木博元、荒野泰
- Organizer
  日本薬学会第135年会
- Place of Presentation
  東京
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25713045
[Presentation] 標的への集積向上を目的とした放射性ガリウム化合物の新規設計2015
- Author(s)
  上原知也
- Organizer
  第15回放射性医薬品・画像診断薬研究会
- Place of Presentation
  京都
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-25713045
[Presentation] SPECT装置を用いたｲﾒｰｼﾞﾝｸﾞとそのプローブ開発2014
- Author(s)
  上原知也
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-25713045
[Presentation] A-Ga-68-labeling reagent liberating Ga--58-NOTA-conjugated methionine from low molecular weight polypeptides in lysosomes for low renal radioactivity levels2013
- Author(s)
  Tomoya Uehara,Mai Kinoshita, Takemi Rokugawa, Guerra Gomez Fransicsco L, Hirofumi Hanaoka, Yasushi Arano
- Organizer
  The 20 th International Symposium on Radiopharmaceutical Sciences
- Place of Presentation
  Jeju (Korea)
- Data Source
  KAKENHI-PROJECT-25713045
[Presentation] 腎放射活性の低減を目的とした放射性ガリウム標識RGDペプチドの開発2013
- Author(s)
  趙　天会，上原知也，根本創紀，花岡宏史，荒野　泰
- Organizer
  第１３回放射性医薬品・画像診断研究会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25713045
[Presentation] 骨疾患部に選択的に集積する^<99m>Tc標識薬剤の開発2010
- Author(s)
  上原知也
- Organizer
  日本核医学会
- Place of Presentation
  大宮
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-21791172
[Presentation] 骨疾患部に選択的に集積する^<99m>Tc標識薬剤の開発2010
- Author(s)
  上原知也
- Organizer
  日本核医学会
- Place of Presentation
  大宮ソニックシティー(大宮)
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-21791172
[Presentation] 肝動脈塞栓療法併用アイソトープ治療を目的とする放射性ヨウ素標識環状ポリアミン誘導体の合成と基礎的検討2009
- Author(s)
  小川愛那, 富岡直子, 黒川将弘, 初芝清徳, 松島理, 秋澤宏行, 上原知也, 荒野泰
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] 抗体のオクタアルギニン修飾が細胞への結合性に及ぼす影響2009
- Author(s)
  宮本怜、秋澤宏行、上原知也、東佑翼、二木史郎、花岡宏史、飯田靖彦、遠藤啓吾、荒野泰
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都国際会館
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-20659186
[Presentation] ^<99m>Tc(CO)_3錯体の生成収率および安定性に及ぼす配位子分子内ピリジン性窒素数の影響2009
- Author(s)
  平林正次, 上原知也, 鈴木優章, 根矢三郎, 荒野泰
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] 99mTc(CO)3錯体の生成収率に及び安定性に及ぼす配位子分子内ピリジン性窒素数の影響2009
- Author(s)
  平林正次、上原知也、鈴木優章、根矢三郎、荒野泰
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都国際会館
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] 抗体のオクタアルギニン修飾が細胞への結合性に及ぼす影響2009
- Author(s)
  宮本怜, 秋澤宏行, 上原知也, 東祐翼, 二木史郎, 花岡宏史, 飯田靖彦, 遠藤啓吾, 荒野泰
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] A simple and convenient method to estimate therapeutic radiopharmaceuticals for transchatheter arterial embolization2008
- Author(s)
  Tomioka N, Akizawa H, Uehara T, Sun W-J, Kurokawa M, Matsushima S, Hatsushiba K, Hashimoto K, Arano Y.
- Organizer
  Society of Nuclear Medicine 2008 Annual Meeting
- Place of Presentation
  New Orleans
- Year and Date
  2008-06-16
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] 標的組織での集積向上を目的とするラジオアイソトープ標識抗体のアルギニンリッチペプチド修飾2008
- Author(s)
  宮本怜、秋澤宏行、上原知也、花岡宏史、飯田靖彦、遠藤啓吾、荒野泰
- Organizer
  第47回日本核医学会総会
- Place of Presentation
  千葉幕張メッセ
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] デンドリマーの体内動態制御に関する基礎的研究2008
- Author(s)
  上原知也, 鈴木博元, 石井大輔, 秋澤宏行, 高間雅志, 村上正裕, 荒野泰
- Organizer
  第48回日本核医学会
- Place of Presentation
  千葉
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] アミノ酸輸送システムAの基質による癌の治療効果判定2008
- Author(s)
  上原知也
- Organizer
  第3回トランスホーター研究会年会
- Place of Presentation
  京都大学薬学部
- Data Source
  KAKENHI-PROJECT-19790856
[Presentation] 多価効果による標的分子への集積向上を目指した新たな99mTc標識薬剤の設計2008
- Author(s)
  宮本怜、秋澤宏行、上原知也、東佑翼、二木史郎、花岡宏史、飯田靖彦、遠藤啓吾、荒野泰
- Organizer
  第48回日本核医学会総会
- Place of Presentation
  千葉幕張メッセ
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20659186
[Presentation]2008
- Author(s)
  秋澤宏行, 宮本怜, 上原知也, 東祐翼, 中瀬生彦, 二木史郎, 花岡宏史, 飯田靖彦, 遠藤啓吾, 荒野泰
- Organizer
  第48回日本核医学会
- Place of Presentation
  千葉
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] 多価効果による標的分子への集積向上を目指した新たな99mTc標識薬剤の設計2008
- Author(s)
  平良優一郎、土屋将夫、内田雪絵、上原知也、秋澤宏行、荒野泰
- Organizer
  第47回日本核医学会総会
- Place of Presentation
  千葉幕張メッセ
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] アミノ酸輸送システムAを標的とした[N-methyl-^<11>C]MeAIB合成の基礎的検討2008
- Author(s)
  加川信也, 西井龍一, 東達也, 上原知也, 岸辺喜彦, 岩崎甚衛, 川井恵一, 荒野泰
- Organizer
  第48回日本核医学会
- Place of Presentation
  千葉
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] 安定なテクネチウムトリカルボニル錯体を形成する新規標識薬剤の開発2008
- Author(s)
  平林正次, 上原知也, 荒野泰
- Organizer
  第48回日本核医学会
- Place of Presentation
  千葉
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] 多価効果による標的分子への集積向上を目指した新たな^<99m>Tc標識薬剤の設計2008
- Author(s)
  上原知也, 平良優一郎, 土屋将夫, 秋澤宏行, 荒野泰
- Organizer
  第48回日本核医学会
- Place of Presentation
  千葉
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] In-111標識抗テネイシンC抗体による急性心筋梗塞後組織修復の非侵襲的評価法の開発2008
- Author(s)
  小高謙一, 上原知也, 荒野泰, 長谷川洋, 田所裕之, 吉田勝哉, 今中恭子, 廣江道昭, 棚田修二, 小室一成, 入江俊章
- Organizer
  第48回日本核医学会
- Place of Presentation
  千葉
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] Prolonged retention of antibody on target by modification with arginine-rich peptide2008
- Author(s)
  Miyamoto R, Akizawa H, Uehara T, Takayama K, Futaki S, Hanaoka H, Iida Y, Endo K, Arano Y.
- Organizer
  Society of Nuclear Medicine 2008 Annual Meeting
- Place of Presentation
  New Orleans
- Year and Date
  2008-06-16
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] デンドリマーの体内動態制御に関する基礎的研究2008
- Author(s)
  鈴木博元、石井大輔、上原知也、秋澤宏行、高間雅志、村上正裕、荒野泰
- Organizer
  第48回日本核医学会総会
- Place of Presentation
  千葉幕張メッセ
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20659186
[Presentation] アミノ酸輸送システムAの基質による癌の治療効果判定2008
- Author(s)
  上原知也
- Organizer
  3回トランスポーター研究会年会
- Place of Presentation
  京都大学薬学部
- Data Source
  KAKENHI-PROJECT-19790856
[Presentation] 安定なテクネチウムトリカルボニル錯体を形成する新規標識薬剤の開発2008
- Author(s)
  平林正次、上原知也、荒野泰
- Organizer
  第47回日本核医学会総会
- Place of Presentation
  千葉幕張メッセ
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] 肝動脈塞栓療法併用アイソトープ治療を目的とする環状ポリアミン誘導体の比較2008
- Author(s)
  秋澤宏行, 富岡直子, 黒川将弘, 上原知也, 荒野泰
- Organizer
  第48回日本核医学会
- Place of Presentation
  千葉
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] 非特異的腎集積を低減する金属RI標識抗体フラグメントの開発2007
- Author(s)
  上原知也, 平林正次, 秋澤宏行, 荒野泰
- Organizer
  第47回日本核医学会
- Place of Presentation
  仙台
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] アミノ酸輸送システムAの基質による癌の治療効果判定2007
- Author(s)
  上原知也
- Organizer
  第47回日本核医学会学術総会
- Place of Presentation
  仙台
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-19790856
[Presentation] デンドリマーの化学修飾による動態制御2007
- Author(s)
  土屋将夫, 石井大輔, 上村友恵, 内田雪絵, 上原知也, 秋澤宏行, 荒野泰
- Organizer
  日本薬学会第128年会
- Place of Presentation
  富山
- Year and Date
  2007-03-28
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] 非特異的腎集積を低減する金属RI標識抗体フラグメントの開発2007
- Author(s)
  上原知也, 平林正次, 秋澤宏行, 荒野泰
- Organizer
  第47回日本核医学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] 標的分子への集積向上を目的とする新たな^<99m>Tc標識薬剤の設計2007
- Author(s)
  上原知也, 土屋将夫, 内田雪絵, 秋澤宏行, 荒野泰
- Organizer
  第47回日本核医学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-18659342
[Presentation] 標的分子への集積向上を目的とする新たな^<99m>Tc標識薬剤の設計2007
- Author(s)
  上原知也, 土屋将夫, 内田雪絵, 平良優一郎, 秋澤宏行, 荒野泰
- Organizer
  第47回日本核医学会
- Place of Presentation
  仙台
- Year and Date
  2007-11-05
- Data Source
  KAKENHI-PROJECT-18390328
[Presentation] A novel chemical design of Ga-67/68 labeled probes based on chelation-madiated multivalency to enhance target accumulation
- Author(s)
  Tomoya Uehara, Yasushi Arano
- Organizer
  International seminar on pharmaceutical science and technology2014
- Place of Presentation
  Bandung, Indonesia
- Year and Date
  2014-09-16 – 2014-09-19
- Invited
- Data Source
  KAKENHI-PROJECT-25713045
[Presentation] 腎放射活性の低減を目的とする低分子ﾎﾟﾘペプチドGa標識薬剤に関する基礎的研究
- Author(s)
  上原知也,横山幹,趙天会,花岡宏史,荒野泰
- Organizer
  第５４回日本核医学会総会
- Place of Presentation
  大阪
- Year and Date
  2014-11-06 – 2014-11-08
- Data Source
  KAKENHI-PROJECT-25713045

1. YASUSHI Arano (90151167)

# of Collaborated Projects: 11 results

# of Collaborated Products: 56 results
2. ENDO Keigo (10115800)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. AKIZAWA Hiromichi (90311795)

# of Collaborated Projects: 3 results

# of Collaborated Products: 35 results
4. HANAOKA Hirofumi (50361390)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. HAYASHI Hideki (20312960)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SHIMADA Hideaki (20292691)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. UEKAWA Naofumi (60282448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAGUCHI Toshiya (20361412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OOSUGA Toshiaki (80223816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TOYOTA Tarou (80422377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SHIMAMOTO Naoto (80295435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SUZUKI Noriyuki (10376379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KAWAI Keiichi (30204663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAGAMACHI Shigeki (40180517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. IRIE Toshiaki (40160072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
16. KOBAYASHI Norihiro (90205477)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. YOSHIDA Kyoko (00242967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. ODADA Kenichi (20443062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. OCHIAI Takenori (80114255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 棚田修二 (40116950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. 石岡典子 (30354963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 渡辺茂樹 (10450305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 近藤浩夫 (40403159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 藤井博史 (80218982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 中野直子 (90222166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 高橋和弘 (20370257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 田中浩士 (40334544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. FUJITO Hiromichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. ODAKA Kenichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

Uehara Tomoya 上原 知也

UEHARA Tomoya 上原 知也

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腎放射活性を低減するradiotheranostic薬剤の新規設計Principal InvestigatorOngoing

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液体合金標的で拓く有用RIの2核種同時製造・標識法の開発Ongoing

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Development of radiotheranostics agent using Fab fragment of anti-regulatory T cellsPrincipal Investigator

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Development of dual-modality SPECT/fluorescent probePrincipal Investigator

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Engineering radiolabeled antibody fragments for enhanced tumor to kidney ratioPrincipal Investigator

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Design of ^<99m>Tc-labled compound for diagnosis of metastatic tumor in bonePrincipal Investigator

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In vivo imaging of DNA repair for estimating the sensitivity of tumor to radiotherapyPrincipal Investigator

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Uehara Tomoya 上原知也

UEHARA Tomoya 上原知也