HANANO Manabu 花野学

Researcher Number	60012598
Affiliation (based on the past Project Information) *help	1993 – 1996: 日本大学, 薬学部, 教授 1990: Fac. Pharm. Sci., Univ. of Tokyo, Professor, 薬学部・附属病院, 教授 1987 – 1990: 東京大学, 薬学部, 教授 1986: Faculty of Pharmaceutical Sciences, University of Tokyo, 薬学部, 教授 1985: 東京大学, 薬, 教授
Review Section/Research Field	Principal Investigator Physical pharmacy / 応用薬理学・医療系薬学 / Biological pharmacy / 医薬分子機能学 Except Principal Investigator 応用薬理学・医療系薬学 / Biological pharmacy / Physical pharmacy
Keywords	Principal Investigator Pharmacokinetics / Glucose metabolism / Brain / Isolated perfused heart / Na^+,K^+ ATPase / Positive inotropic action / Ouabain / Cardiac glycosides / Na^+,Ka^+ATPase / ベンゾジアゼピン … More / K^+ATPase / Na^+ / ベンゾジアゼピンレセプター / グルコース代謝 / 脳 / 心臓灌流実験 / Na^+,K^+ATPase / 心筋収縮力 / ウアバイン / 強心配糖体 / uneven distribution of hepatic metabolic enzymes / species difference / drug disposition / animal scale-up / physiologically based pharmacokinetics / 薬物間相互作用 / 肝機能の局在性 / 動物種差 / 薬物の体内動態 / アニマルスケールアップ / 生理学的薬物速度論 / protein binding / fluorescence probe / pharmacokinetics / orosomucoid / <alpha_1> -acid glycoproterin / ファーマコキネティクス / オロソムコイド / 薬物モニタリング / 蛋白結合 / プロプラノロール / けい光色素 / 【α_1】-酸性糖蛋白 / Peptide drug / Drug targeting / Drug absorption / Cell membrane permeation / Physiological model / 鎮痛薬 / ペプチド薬物 / 薬物ターゲッティング / 薬物吸収 / 細胞膜透過 / 生理学的モデル / 薬物体内動態 / beta-lactam antibiotic / Blood-Cerebrospinal Fluid Barrier / Blood-Brain Barrier / ドラッグデリバリ-システム / 脳毛細血管内皮細胞 / 血液脳関門 / β-ラクタム抗生物質 / 血液-脳脊髄液関門 / 血液-脳関門 / 薬物速度論 / βーラクタム抗生物質 / 血液・脳脊髄液関門 / 血液・脳関門 / internalization / down-regulation / epidermal growth factor (EGF) / receptor-mediated endocytosis / 内在化 / ダウンレギュレ-ション / 上皮成長因子(EGF) / 受容体介在性エンドサイト-シス … More Except Principal Investigator 薬物速度論 / efflux pump / cloning / blood-brain barrier / pharmacokinetics / tissue targeting / receptor / transporter / drug delivery / hepatic failure / renal failure / choroid plexus / cerebrospinal fluid / Blood-brain barrier / DL-プロプラノロール / デシプラミン / イミブラミン / 腎障害ラット / 薬物脳移行 / 脈絡叢 / 血液-脳脊髄液関門 / 血液-脳関門 / 血液脳脊髄液関門 / 腎障害 / 肝障害 / 血液脳脊髄関門 / 血液脳関門 / spinal cord / noradrenaline / muscle relaxants / antispastic drugs / αアンタゴニスト / αアゴニスト / スリクロン / バクロフェン / 2ーデオキシグルコース法 / 脊髄 / ノルアドレナリン / 筋弛緩薬 / 抗痙縮薬 / 組織標的化 / レセプター / トランスポーター / ドラッグデリバリー / effux pump Less

Research Projects
(9 results)
Co-Researchers
(22 People)

Clarification of organ specific transport mechanism of druge and its application to regulation of pharmacokinetics and pharmacodynamics
- Principal Investigator
  
  TSUJI Akira
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kanazawa University
Prediction and control effectiveness and safety of a drug by means of pharmacokinetics based on physiological and biochemical mechanism of its disposition in body.Principal Investigator
- Principal Investigator
  
  HANANO Manabu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Nihon University
Kinetic analysis of receptor-mediated endocytosis of polypeptide hormonesPrincipal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi, 花野学
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokyo
Development of a drug delivery system using the receptors located on the cerebral microvessels : An approach based on the physiological pharmacokinetio model.Principal Investigator
- Principal Investigator
  
  SUGIYAMA Yuichi, 花野学
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokyo
Kinetic Analysis of the CNS Disposition of Drugs in the Renal and Hepatic Failure
- Principal Investigator
  
  IGA Tatsuji
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo
Kinetical analysis of pharmacodynamics based on drug-receptor interactionsPrincipal Investigator
- Principal Investigator
  
  HANANO Manabu
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Tokyo
Pharmacological and Pharmacokinetic Studies on Anti-spastic Drugs
- Principal Investigator
  
  FUKUDA Hideomi
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Comprehensive study on the predition of drug disposition based on the physiological and anatomical mechanism.Principal Investigator
- Principal Investigator
  
  HANANO Manabu
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  University of Tokyo
Development of a simple and rapid determination method of <alpha_1> -acid glycoprotein in plasma.Principal Investigator
- Principal Investigator
  
  HANANO Manabu
- Project Period (FY)
  1984 – 1985
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo

1. SUGIYAMA Yuichi (80090471)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
2. SAWADA Yasufumi (80114502)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. AWAZU Souji (60012621)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. FUKUDA Hideomi (50080172)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. IGA Tatsuji (60012663)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. TUJI Akira (10019664)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUZUKI Hiroshi (80206523)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YATA Noboru (70028835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HAYASHI Masahiro (20012669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MAYUMI Tadanori (00098485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HASHIDA Mitsuru (20135594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HORI Ryohei (40001036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HOSHI Takeshi (60004537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MATSUMOTO Kinzo (10114654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ONO Hideki (00080200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SUGIMOTO Tsuneaki (60019883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山本郁男 (50069746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 渡辺淳 (80080175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 原島秀吉 (00183567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SASAHARA Kunihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KOBAYASHI Yutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KURITA Masahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HANANO Manabu 花野 学

Research Projects

Co-Researchers

Clarification of organ specific transport mechanism of druge and its application to regulation of pharmacokinetics and pharmacodynamics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prediction and control effectiveness and safety of a drug by means of pharmacokinetics based on physiological and biochemical mechanism of its disposition in body.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Kinetic analysis of receptor-mediated endocytosis of polypeptide hormonesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a drug delivery system using the receptors located on the cerebral microvessels : An approach based on the physiological pharmacokinetio model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Kinetic Analysis of the CNS Disposition of Drugs in the Renal and Hepatic Failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Kinetical analysis of pharmacodynamics based on drug-receptor interactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pharmacological and Pharmacokinetic Studies on Anti-spastic Drugs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive study on the predition of drug disposition based on the physiological and anatomical mechanism.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a simple and rapid determination method of <alpha_1> -acid glycoprotein in plasma.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HANANO Manabu 花野学