KOSAKA Hiroaki 小坂博昭

… Alternative Names

小阪博昭コサカヒロアキ

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Researcher Number	60158897
Other IDs
Affiliation (based on the past Project Information) *help	2009 – 2015: 香川大学, 医学部, 教授 2003 – 2006: 香川大学, 医学部, 教授 2004: Kagawa University, Faculty of Medicine, Professor, 医学部, 教授 2001: Kagawa University, FACULTY OF MEDICINE, Professor, 医学部, 教授 1997 – 2001: Medical University Dept.of Physiology 2, Professor, 医学部, 教授 … More 1999: Kagawa Medical University, Second Department of Physiology, PROFESSOR, 医学部, 教授 1996: 大阪大学, 医学部, 講師 1993 – 1994: 大阪大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator General physiology / General physiology / 環境影響評価(含放射線生物学) Except Principal Investigator Dermatology / Biomedical engineering/Biological material science / Plastic surgery / General physiology / Cardiovascular medicine / Circulatory organs internal medicine
Keywords	Principal Investigator NO / S1P1 / Nitric oxide / EDCF / NO合成酵素 / ヘモグロビン / 電子スピン共鳴 / 一酸化窒素(NO) / Sphingosine-1 Phosphate / Arginine … More / Nitric oxide synthase / ROS / NADPH oxidase / 成長因子 / G蛋白質結合型受容体 / 内皮型NO合成酵素 / 血管新生 / スフィンゴ脂質 / 血管内皮細胞 / スフィンゴシン1リン酸 / アルギニン / 活性酸素 / NADPHオキシダーゼ / apoptosis / hypertension / migration / angitensin / mast cell / superoxide / アポトーシス / 高血圧 / 白血球接着・遊走 / アンギオテンシンII / 肥満細胞 / スーパーオキサイド / angina / isosobide dinitrate / nitroglycerin / EPR / ESR / oxygen relrease / hemoglohin / nitric oxide / 一酸化窒素 / 硝酸イソソルビド / ニトログリセリン / 狭心症 / 顕微分光 / 酸素放出 / allograft rejection / ischemic-gamma perfusion / nitric oxide synthase / hemoglobin / oxygen saturation / electron spin resonance / nitric oxide (NO) / nitrosamine / 腫瘍壊死因子 / サイトカイン / 酸素飽和度 / 移植拒絶反応 / 虚血再潅流 / 酵素飽和度 / ニトロソアミン / AIF / ＡＩＦ / 分子機序 / 膜結合様式 / カスパーゼ非依存性細胞死 / ミトコンドリア / 細胞死 … More Except Principal Investigator 血管新生 / 血管内皮 / VEGF / 血管内皮細胞 / サイトカイン / vascular endothelial cell / lipid / platelet / apoptosis / PDGF / 血管成熟 / カスパーゼ / 過酸化水素 / S1P / 脂質 / 血小板 / アポトーシス / Vasodilation / Atheroscrerosis / Propagation velocity / Cross correlation / Pulse wave velocity / Doppler ultrasound / 局所脈波速度 / 脈波速度 / 局所脈派速度 / 心エコー・ドプラ検査 / 超音波ドプラ法 / 脈派速度 / 動脈硬化 / HYPERTENSION / NITRIC OXIDE / ANGIOTENSIN II / REACTIVE OXIGEN / SUPEROXIDE / FREE RADICAL / SKIN FLAP / MICROCIRCULATION / 高血圧 / NO / アンギオテンシンII / 活性酸素 / スーパーオキサイド / フリーラジカル / 皮弁 / 微小循環 / Species adaptation / Artificial mutants / Site-directed mutagenesis / Protein engneering / Ligand affinity / Oxygen affinity / Hemoglobin / 人工変異蛋白質 / 種の適応 / 人工変異体 / 部位特異的変異導入 / 蛋白質工学 / リガンド親和性 / 酸素親和性 / ヘモグロビン / 成長因子 / 受容体 / 内皮細胞 / 角化細胞 / 表皮角化細胞 / 皮膚線維芽細胞 / カベオラ / カベオリン１ / シグナル伝達 / ステロイド / 皮膚 / カベオリン / caveolin-1 / 受容体シグナリング / 細胞内情報伝達機構 / スフィンゴ脂質 / 脂質メディエーター / 心筋虚血 Less

Vessel maturation by a cytokine TGFbeta1 and crosstalk with VEGFR2 signaling
- Principal Investigator
  
  Igarashi Junsuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kagawa University
The effects of glucocorticoid on the expression of caveolin-1 in skin-related cells.
- Principal Investigator
  
  KUBOTA YASUO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kagawa University
Induction mechanism of AIF-related cell deathPrincipal Investigator
- Principal Investigator
  
  KOSAKA Hiroaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kagawa University
Exploring the roles of sphingosine 1-phosphate(S1P), a lipid mediator, in ischemic heart
- Principal Investigator
  
  IGARASHI Junsuke
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kagawa University
Cross-talk between S1P and VEGF in cutaneous vascular maturation, and its relationship to pathogenesis of psoriasis
- Principal Investigator
  
  KUBOTA Yasuo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kagawa University
Molecular mechanism on the maturation of tissue oxygen supply systemPrincipal Investigator
- Principal Investigator
  
  KOSAKA Hiroaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kagawa University, Faculty of Medicine
  香川大学(医学部)
A Newly-Developed Method of Measuring Local Pulse Wave Velocity for Assessing of Severiy of Arteriosclerosis and Characteristics of Endotherial-Dependent Vasodilation
- Principal Investigator
  
  SENDA Shoichi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kagawa University
Endothelial function regulating migration of leukocytes to tissuesPrincipal Investigator
- Principal Investigator
  
  KOSAKA Hiroaki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  General physiology
- Research Institution
  Kagawa Medical University
A study of on the microcirculation and free radicals during attachment of skin flap
- Principal Investigator
  
  HATA Yuiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Plastic surgery
- Research Institution
  Tokyo Medical and Dental University
  香川医科大学
A new role of NO on the accelerating effect of oxygen supply to tissuePrincipal Investigator
- Principal Investigator
  
  KOSAKA Hiroaki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Kagawa Medical University
  Osaka University
Endogenous induction of nitrosaminesPrincipal Investigator
- Principal Investigator
  
  KOSAKA Hiroaki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Osaka University
Study of the regulation mechanism of ligand affinity of hemoglobin by protein engineering
- Principal Investigator
  
  IMAI Kiyohiro
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Osaka University

All 2014 2013 2012 2011 2010 2009 2004 2003

All Journal Article Presentation

[Journal Article] Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells2014
- Author(s)
  Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, TakuwaY, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I.
- Journal Title
  
  Pharmacology Research & Perspectives
  
  Volume: 2 Issue: 5 Pages: 68-68
- DOI
  10.1002/prp2.68
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390051, KAKENHI-PROJECT-24591654, KAKENHI-PROJECT-24790123, KAKENHI-PUBLICLY-25116711, KAKENHI-PROJECT-25461132, KAKENHI-PROJECT-25670162, KAKENHI-PROJECT-26220203
[Journal Article] Lipid peroxidation-induced VEGF expression in the skin of KKAy obese mice2011
- Author(s)
  Nakai K, Yoneda, K, Ishihara Y, Ohmori K, Moriue T, Igarashi J, Kohno M, Kosaka H and Kubota Y
- Journal Title
  
  Experimental Dermatology
  
  Volume: 20(5) Pages: 388-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Reaction mechanism of single subunit NADH-ubiquinone oxidoreductase(Ndi1) from Saccharomyces cerevisiae : evidence for a ternary complex mechanism2011
- Author(s)
  Yang Y, Yamashita T, Nakamaru-Ogiso E, Hashimoto T, Murai M, Igarashi J, Miyoshi H, Mori N, Matsuno-Yagi A, Yagi T and Kosaka H
- Journal Title
  
  J Biol Chem
  
  Volume: 286(11) Pages: 9287-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Activation of vascular endothelial growth factor receptor 2 in a cellular model of loricrin keratoderma2010
- Author(s)
  Yoneda K, Demitsu T, Nakai K, Moriue T, Ogawa W, Igarashi J, Kosaka H, and Kubota Y
- Journal Title
  
  J Biol Chem
  
  Volume: 285(21) Pages: 16184-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Expression of wild-type, but not mutant, loricrin causes programmed cell death in HaCaT keratinocytes2010
- Author(s)
  Yoneda K, Demitsu T, Manabe M, Igarashi J, Kosaka H, Inagaki N, Takahashi H, Kon A, Kakuai M and Kubota Y
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 37(11) Pages: 956-64
- NAID
  10027572660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] A novel nucleic acid analogue shows strong angiogenic activity2010
- Author(s)
  Tsukamoto I, Sakakibara N, Maruyama T, Igarashi J, Kosaka H, Kubota Y, Tokuda M, Ashino H, Hattori K, Tanaka S, Kawata M and Konishi R
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 399(4) Pages: 699-704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Transforming Growth Factor-{ beta} 1 Down-Regulates Caveolin-1 Expression And Enhances Sphingosine 1-Phosphate Signaling In Cultured Vascular Endothelial Cells2009
- Author(s)
  Igarashi J, Shoji K, Hashimoto T, Moriue T, Yoneda K, Takamura T, Yamashita T, Kubota Y, and Kosaka H
- Journal Title
  
  Am. J. Physiol.(Cell Physiology)
  
  Volume: 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590933
[Journal Article] Blood flow-dependent changes in intrarenal nitric oxide levels during anesthesia with halothane or sevoflurane.2004
- Author(s)
  K.Kusudo, K.Ishii, M.Rahman, Y.Aki, A.Miyatake, H.Kosaka, S.Kimura, T.Komatsu, M.Yokoyama, K.Morita, Y.Abe, A.Nishiyama.
- Journal Title
  
  Eur.J.Pharmacol. 498
  
  Pages: 267-273
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] Effects of thiol antioxidant on NADPH Oxidase in hypertensive Dahl Salt-Sensitive Rats.2004
- Author(s)
  L Zhang, S Fujii, J Igarashi, H Kosaka
- Journal Title
  
  Free Radical Biology & Medicine 37
  
  Pages: 1813-1820
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] Inhibition of NF-κB activation and iNOS transcription by prolonged exposure to high glucose in human keratinocyte cell line, HaCaT.2004
- Author(s)
  K.Nakai, Y.Kubota, H.Kosaka
- Journal Title
  
  Br J Dermatol 150
  
  Pages: 640-646
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] Nitric Oxide Synthase Inhibition by N(G)-Nitro-L-Arginine Methyl Ester Retards Vascular Sprouting in Angiogenesis.2003
- Author(s)
  K.Kon, S.Fujii, H.Kosaka, T.Fujiwara.
- Journal Title
  
  Microvasc Res 65
  
  Pages: 2-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] Ascorbate enhances iNOS activity by increasing tetrahydrobiopterin in RAW 264.7 cells.2003
- Author(s)
  K Nakai, M Urushihara, Y Kubota, H Kosaka
- Journal Title
  
  Free Radical Biology & Medicine 35
  
  Pages: 929-937
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and opposing effect of L-arginine.2003
- Author(s)
  H Kosaka, H Yoneyama, L Zhang, S Fujii, A Yamamoto, J Igarashi
- Journal Title
  
  FASEB J. 17
  
  Pages: 636-643
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] L-Arginine reverses p47phox and gp91phox expression induced by high salt in Dahl rats2003
- Author(s)
  S Fujii, L Zhang, J Igarashi, H Kosaka
- Journal Title
  
  Hypertension 42
  
  Pages: 1014-1020
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] Effects of high glucose on NOsynthesis in human keratinocyte cell line (HaCaT).2003
- Author(s)
  K.Nakai, S.Fujii, A.Yamamoto, J.Igarashi, Y.Kubota, H.Kosaka
- Journal Title
  
  J.Dermatological Science. 31
  
  Pages: 211-218
- NAID
  50000851268
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Journal Article] Induction of LOX-1 and iNOS expressions by ischemia-reperfusion of rat kidney and opposing effect of L-arginine2003
- Author(s)
  H Kosaka
- Journal Title
  
  FASEB J 17
  
  Pages: 636-643
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590186
[Presentation] 新規核酸類似物質COA-Clによる血管新生反応におけるS1P1受容体の役割2014
- Author(s)
  五十嵐淳介、窪田泰夫、小路和代、榊原紀和、丸山徳見、高田真紀、小坂博昭、多久和陽、橋本剛、山下哲生、小西良二、塚本郁子
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] Apoptosis-inducing factor依存的細胞死の制御機構の解析2014
- Author(s)
  山下哲生、橋本剛、五十嵐淳介、小坂博昭
- Organizer
  第５５回日本生化学会中国四国支部例会
- Place of Presentation
  愛媛大学城北キャンパス
- Data Source
  KAKENHI-PROJECT-23590260
[Presentation] Apoptosis-inducing factor (AIF)の膜への結合様式の解析2014
- Author(s)
  山下哲生、橋本剛、五十嵐淳介、小坂博昭
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学
- Data Source
  KAKENHI-PROJECT-23590260
[Presentation] S1P1 Receptors Mediate Angiogenic Responses Of A Novel Adenosine Analogue COA-Cl In Human Umbilical Vein Endothelial Cells (HUVEC)2013
- Author(s)
  Junsuke Igarashi, Yasuo Kubota, Kazuyo Shoji, Norikazu Sakakibara, Tokumi Maruyama, Maki Takata, Hiroaki Kosaka, Ryoji Konishi, Ikuko Tsukamoto
- Organizer
  Scientific Sessions, American Heart Association
- Place of Presentation
  アメリカ合衆国テキサス州ダラス市
- Data Source
  KAKENHI-PROJECT-25461132
[Presentation] TGFβ1 down-regulates VEGFR-2 and attenuates VEGF-induced activation of protein kinase Akt in cultured endothelial cells2012
- Author(s)
  Igarashi J, Shoji K, Hashimoto T, Tsukamoto I, Yoneda K, Kubota Y, and Kosaka H
- Organizer
  日本生理学会
- Place of Presentation
  長野県松本市
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] Glucocorticoid(GC) up-regulates expression of caveolin-1(cav-1) and attenuates VEGF responses in endothelial cells(EC)2011
- Author(s)
  Igarashi J, Shoji K, Hashimoto T, Yoneda K, Moriue T, Tsukamoto I, Kubota Y, and Kosaka H
- Organizer
  日本生理学会
- Place of Presentation
  誌上開催
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] ステロイド受容体アゴニストはcaveolin-1(cav-1)発現を増加させることで血管内皮のVEGF反応を抑制する2011
- Author(s)
  五十嵐淳介、小路和代、橋本剛、米田耕造、森上徹也、塚本郁子、窪田泰夫、小坂博昭
- Organizer
  日本心脈管作動物質学会
- Place of Presentation
  香川県高松市
- Year and Date
  2011-02-04
- Data Source
  KAKENHI-PROJECT-21590933
[Presentation] Steroid Hormones Induce Caveolin-1(cav-1) And Attenuate vascular endothelial growth factor(VEGF) Responses In Cultured Vascular Endothelial Cells(EC)2010
- Author(s)
  Igarashi J, Hashimoto T, Shoji K, Yoneda K, Kubota Y, and Kosaka H
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  アメリカ合衆国イリノイ州シカゴ市
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-21590933

1. IGARASHI Junsuke (20346638)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
2. HASHIMOTO Takeshi (80380153)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. KUBOTA YASUO (10126047)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. YONEYAMA Hirohito (80294750)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. FUJII Shigemoto (00325333)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. OHIRA Tetsuya (50448031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KITAMURA Akihiko (80450922)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KUMURA Eiji (50260633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIGA Takeshi (10028350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. IMAI Kiyohiro (50028528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MIYAZAKI Gentaro (50166146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SEIYAMA Akitoshi (70206605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMAMOTO Akira (70314911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HATA Yuiro (90164839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SENDA Shoichi (30145049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MIZEUSHIGE Katsufumi (90166009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MAETA Hajime (00075508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OMORI Koji (00263913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 山下哲生 (80444727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. 渡邉学 (30182950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 阪本整司 (60253267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 松尾裕英 (90028514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 多久和典子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 岡本安雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 多久和陽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOSAKA Hiroaki 小坂 博昭

小阪 博昭 コサカ ヒロアキ

Research Projects

Research Products

Co-Researchers

Vessel maturation by a cytokine TGFbeta1 and crosstalk with VEGFR2 signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effects of glucocorticoid on the expression of caveolin-1 in skin-related cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction mechanism of AIF-related cell deathPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploring the roles of sphingosine 1-phosphate(S1P), a lipid mediator, in ischemic heart

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cross-talk between S1P and VEGF in cutaneous vascular maturation, and its relationship to pathogenesis of psoriasis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism on the maturation of tissue oxygen supply systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Newly-Developed Method of Measuring Local Pulse Wave Velocity for Assessing of Severiy of Arteriosclerosis and Characteristics of Endotherial-Dependent Vasodilation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Endothelial function regulating migration of leukocytes to tissuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study of on the microcirculation and free radicals during attachment of skin flap

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new role of NO on the accelerating effect of oxygen supply to tissuePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Endogenous induction of nitrosaminesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the regulation mechanism of ligand affinity of hemoglobin by protein engineering

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells2014

Author(s)

Journal Title

KOSAKA Hiroaki 小坂博昭

小阪博昭コサカヒロアキ