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Ohashi Toya  大橋 十也

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… Alternative Names

OHASHI TOYA  大橋 十也

OHASHI T.  大橋 十也

OHASHI Toya  大橋 十也

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Researcher Number 60160595
Other IDs
External Links
Affiliation (Current) 2025: 東京慈恵会医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2012 – 2022: 東京慈恵会医科大学, 医学部, 教授
2001 – 2004: Jikei Univ. Sch. Med., Gene Therapy, Assoc. Professor, DNA医学研究所, 助教授
2001 – 2004: Jikei Univ.,Dept. of Pedatrics, asso prof., 医学部, 助教授
2003: Jikei University School of Medicine, Associate Professor, 医学部, 助教授
2000: 東京慈恵会医科大学, DNA医学研究所, 講師 … More
1999 – 2000: 東京慈恵会医科大学, 医学部, 講師
1997 – 1999: Jikei University School of Medicine assi prof., 医学部・小児科, 講師
1998: 東京慈恵会医科大学, 小児科学講座, 講師
1997: 東京慈恵会医科大学, 医学部・小児科学講座, 講師
1996: 東京慈恵会医科大学, 医学部小児科, 講師
1996: The Jikei University School of Medicine assi.prof., 小児科, 講師
1995: 東京慈恵会医科大学, 医学部・小児科学, 助手
1995: 東京慈恵会医科大学, 医学部・微生物学第一, 助手
1995: 東京慈恵会医科大学, 小児科学, 助手
1992 – 1995: 東京慈恵会医科大学, 医学部, 助手
1993: 東京慈恵会医科大学, 医学部・小児科, 助手
1993: assistant, 小児科, 助手
1988: THE JIKEI UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF PEDIATRICS
1988: 東京慈恵会医科大学, 小児科, 助手
1986 – 1987: 東京慈恵会医科大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Pediatrics / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Except Principal Investigator
Pediatrics / Neurology / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Digestive surgery
Keywords
Principal Investigator
遺伝子治療 / beta-glucuronidase / Sly disease / Sly病 / ムコ多糖症 / MPS VII / retrovirus / β-glucuronidase / ライソゾーム病 / 免疫寛容 … More / 抗体 / 酵素補充療法 / ファブリー病 / GM1ガングリオシドーシス / GM1ガングリオシドーシス / アデノ随伴ウイルスベクター / レンチウイルスベクター / 造血幹細胞 / GM1ガングリオシド―シス / 先天代謝異常学 / 遺伝・先天異常学 / 先天代謝異常 / 先天代謝異常症 / 遺伝・先天異常 / AAV / Gene Therapy / MPSVII / アデノ随伴ウイルス / gene therapy / Macrophage / Sly病(Sly disease) / 遺伝子導入 / Slyマウス / レトロウイルスベクター / マクロファージ / transduction / CD34+ cells / adenovirus / モデルマウス / 骨髄前駆細胞 / サザンブロット法 / CD34+細胞 / β-glucuronidase遺伝子 / ヒト骨髄細胞 / ムコ多糖症VII型 / LTCIC(Long Term Culture Iniciating Cell) / NOD-SCIDマウス / 骨髄幹細胞(CD34+細胞) / 骨髄細胞 / アデノウイルス / レトロウイルス / 免疫寛容療法 / ポンペ病 / 経口投与 / 抗CD3抗体 / ポンぺ病 / ライソゾーム病蓄積症 / 脳血管関門 / HIV-Tat … More
Except Principal Investigator
遺伝子治療 / Gaucher disease / アデノウイルスベクター / MLD / gene therapy / ゴーシェ病 / Twitcherマウス / 動物モデル / ゴ-シェ病 / レトロウイルスベクター / 遺伝子変異 / Gaucher病 / 異染性脳白質変性症 / Krabbe病 / Adenovirus / 酵素補充療法 / 臨床表現型 / アデノウイルス / SOD1 / Motoneuron / Facial nerve / Avulsion / 運動ニューロン / 神経栄養因子 / Gene Tharapy / 中枢神経症状 / 中枢神経 / リソゾーム病 / Neurolipidosis / 骨髄移植 / genotype / 遺伝子解析 / リピドーシス / レトロウイルス / ライソゾーム病 / ムコ多糖症II型 / Monoclonal antibody / Arylsulfatese A / 細胞内プロセシング / DNA診断 / アリルサルファターゼA.B,C-DNAのクローニング / C-DNAのクローニング / アミノ酸配列 / 精製 / アリルサルファターゼA・B / 抗体作成 / 酵素精製 / CDNAクローニング / モノクローナル抗体 / アリルサルファターゼA / mitosis / centromere / checkpoint / Wilms'tumor / chromosome instability / aneuploidy / 紡錘糸チェックポイント / 有糸分裂 / セントロメア / チェックポイント / ウィルムス腫瘍 / 染色体不安定性 / 異数染色体 / Schwann cell / ALS / Neurotrophic factor / Adenovirus vector / 運動神経損傷 / 顔面神経 / シュワン細胞 / 筋萎縮性側索硬化症 / Retrovirus vector / Krabbe disease / Pre-natal Gene therapy / Leucodystrophy / Gene Therapy / ムコ多糖症 / 遺伝性白質変性症 / クラッベ病 / 出生前治療 / 遺伝性脳白質変性症 / CNS involvement / mouse model / lipidosis / 胎児治療 / 神経細胞 / TGFβ2 / BDNF / GDNF / Gene therapy / カルジオトロフィン-1 / アデノウイルスベクター(3) / グリア細胞株由来神経栄養因子(GDNF) / TGFβ / 毛様体神経栄養因子(CNTF) / 脳由来神経栄養因子(BDNF) / neurophic factor / krabbe病 / MPS VII / lysosomal disorder / mutation / Twitcher マウス / ミクログリア / Cytkine / Adenovirus Vector / Niemann-Pick Disease TypeC / Neural progenitor / Nieman-Pick病typeC / Niemann-Pick病type C / サイトカイン / β-galactosidase / Nieman-Pick病type C / phenotype / enzyme replacement therapy / 遺伝子異変 / Fabry disease / genetic disorder / chromosomal disorders / lectin method / prenatal diagnosis / fetal blood / maternal blood / CD71 / 胎児血 / 母体 / ファブリー病 / 遺伝病 / 染色体異常症 / レクチン法 / 出生前診断 / 胎児血球 / 母体血 / Sly mice / Twitcher mice / neural stem cell therapy / Sjogren-Larsson / 遺伝子異常 / Slyマウス / 神経幹細胞 / metachromatic leukodystrophy / MPS VII mice / beta-glucuronidase / ムコ多糖症VII型 / リソゾーム蓄積症 / モデルマウス / 臨床症状 / Animal model / Gene mutation / Retrovirus / Inborn errors of metabolism / 遺伝子導入効率 / 先天代謝異常症 / Conduritol-B-epoxedo (CBE) / glucocerebroside / 細胞内カルシウム濃度 / Conduritol-B-epoxide(CBE) / Human Oligodendroglioma(HOG)細胞 / glucosylsphingosine / プロティンキナーゼC活性 / スフィンゴリピド / glicosylsphingosine / 遺伝性ロイコヂストロフィー症 / サイコシン / Metachromatic leukodystrophy(MLD) / グルコセレブロシダーゼ / L444P / common mutation / transplantation / Genotype / Phenotype / 胎児造血幹細胞 / ニーマンピック病 / 遺伝子変異分布 / SSCP法 / 神経型ゴ-シェ病 / 脳血液関門破壊 / 脳変性疾患 / PCR-SSCP / Arylsulfatase A / RT-PCR / Gaucher Disease / 遺伝型と臨床型 / アリルスルファターゼA遺伝子 / SSCP / ASO / PCR / PMD / PCR-SSCP法 / ArylsulfataseA / 遺伝子変異解析 / RT-PCR法 / matachromatic leukodystrophy(MLD) / 先天性ミエリン形成異常症 / retroviral vector / deficient cholesterol esterification / fetus gene therapy / Niemann-Pick disease type C / コレステロールエステル / Ca代謝 / 脳血液関門 / アデノウィルスベクター / 胎児肝臓 / Lacz遺伝子 / レトロウィルスベクター / コレステロールのエステル化障害 / 胎児遺伝子治療 / ヒトニーマンピック病タイプC / demyelination / Krabbe's disease / Metachromatic / スプライスアクセプターサイト / PCR法 / 制限酵素 / ミエリン形成異常症 / 呼吸鎖リン酸化反応 / 脱髄 / クラベ病 / 異染性白質変性症 / Nerve Growth Factor / レンチウイルス / イズロン酸サルファターゼ / 骨質系 / 骨芽細胞 / Hunter syndrome / 骨代謝 / レンチウイルスベクター / 病理 / 骨病変 / ムコ多糖症Ⅱ型 / 神経症状 / ケミカルシャペロン / 外科 / ADENO VIRUS / 投与条件 / 肝臓 / RSV / CMVpromotor / SV-40 / ヘルペスウイルスベクター / ニーマンピック病マウス / クラッベ病マウス / サルファターゼ / オリゴデンドロサイト Less
  • Research Projects

    (33 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (38 People)
  •  Hematopoietic stem cell gene therapy using engineered enzyme with high penetrating ability for mucopolysaccharidosis type II

    • Principal Investigator
      SHIMADA Yohta
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Development of Hematopoietic Stem Targeted Gene Therapy for GM1-gangliosidosisPrincipal Investigator

    • Principal Investigator
      Ohashi Toya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Development of efficient enzyme replacement therapy for lysosomal storage disease with immune modulationPrincipal Investigator

    • Principal Investigator
      Ohashi Toya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Analysis of the Pathophysiological Mechanism of Bone Lesion in Mucopolysaccharidosis Mouse Model ; Its Natural History and Therapeutic Effect

    • Principal Investigator
      Ida Hiroyuki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Development of effective treatment by immune tolerance induction in enzyme replacement therapy for lysosomal storage diseasesPrincipal Investigator

    • Principal Investigator
      OHASHI TOYA
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  ゴーシェ病の中枢神経症状発現機序及び治療に関する研究

    • Principal Investigator
      井田 博幸
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  脳血管関門を通過する酵素製剤の開発に関する研究Principal Investigator

    • Principal Investigator
      大橋 十也
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Development of novel therapy and elucidation of pathophysiology for genetic leukodystrophy

    • Principal Investigator
      ETO Yoshikatsu
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Neuropathological and therapeutic studies on adult motoneuron degeneration using rat peripheral nerve avulsion models

    • Principal Investigator
      WATABE Kazuhiko
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Cloning of a novel tumor suppressor gene in Wilms' tumor associated with chromosome instability

    • Principal Investigator
      SUZUKI Hideaki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      JIKEI UNIVERSITY SCHOOL OF MEDICINE
  •  Gene therapy for neurogical abnormality using mouse model of lipidosis

    • Principal Investigator
      IDA H, 洲鎌 盛一
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Adenoviral gene transfer of neurotrophic factors to injured adult motoneurons

    • Principal Investigator
      WATABE Kazuhiko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      TOKYO METROPOLITAN ORGANIZATION OF MEDICAL RESEARCH
  •  Molecular Pathogenesis of Brain Damage and Gene Therapy in Genetic Leukodystrophy

    • Principal Investigator
      ETO Yoshikatsu
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University Shool of Medicine
  •  Prenatal Diagnosis of Ingenited Metabolic Disorders Using Maternal Blood

    • Principal Investigator
      ETO Yoshikatsu
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University Shool of Medicine
  •  Gene therapy for central nervous involvement of Gaucher disease

    • Principal Investigator
      IDA Hiroyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene Therapy for Sly disease using AAV vector.Principal Investigator

    • Principal Investigator
      OHASHI Touya
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Treatment for congenital metabolic disorder with brain dysfunction.

    • Principal Investigator
      TOKORO Toshiharu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for Krabbe disease with microglial cells derived from brain

    • Principal Investigator
      GOMIBUCHI Ichizou
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for brain damage using animal models with lipidoses

    • Principal Investigator
      SUGAMA Seiichi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for CNS involvement of Lysosomal storage disease using various viral vector

    • Principal Investigator
      ITO Fumiyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  ADENOVIRAL VECTORを 使用した肝臓に対する遺伝子治療における投与条件の基礎的検討

    • Principal Investigator
      岡本 友好
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Jikei University School of Medicine
  •  Studies of inherited neurodegenerative disease ; mutation analysis and gene therapy

    • Principal Investigator
      MAEKAWA K.
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for Sly diseasePrincipal Investigator

    • Principal Investigator
      OHASHI T.
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for neuronopathic Gaucher disease

    • Principal Investigator
      IDA H.
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  The cause of neuropathochemistry of inherited Neurodegeneration

    • Principal Investigator
      ETO Yoshikatsu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  リピドーシス動物モデルを用いての中枢神経障害の遺伝子治療

    • Principal Investigator
      衛藤 義勝
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Gene Therapy toward to nuerodegenerative disorders using fetal hematopoietic stem cells transplantation

    • Principal Investigator
      IDA Hiroyuki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene Therapy for Lysosomal Strage DiseasePrincipal Investigator

    • Principal Investigator
      OHASHI Touya
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  リピドーシス動物モデルを用いての中枢神経障害の遺伝子治療

    • Principal Investigator
      ETO Y.
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Molecular Analysis and Gene Therapy in Inherited dysmyelinating disorder

    • Principal Investigator
      MAEKAWA Kihei
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for inherited neurodegenerative disease using fetal bone marrows stem cell transplantation.

    • Principal Investigator
      TOKORO Toshiharu
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei Univ.School of Medicine
  •  Studies of genetic analysis and gene therapy for myelin-associated disorders.

    • Principal Investigator
      MAEKAWA Kihei
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  c DNA cloning for human Arylsulfatase A

    • Principal Investigator
      ITO Fumiyuki
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine

All 2023 2022 2021 2017 2005 2004 2003 2002 Other

All Journal Article Presentation Book

  • [Book] ファブリー病の治療、酵素補充療法,ファブリー病-基礎から臨床までの最近の知見-2004

    • Author(s)
      大橋十也
    • Total Pages
      10
    • Publisher
      ブレーン出版(株)
    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] A novel preclinical model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy2023

    • Author(s)
      Shimada Y, Ishii N, Higuchi T, Goto M, Ohashi T, Kobayashi H
    • Journal Title

      Gene Therapy

      Volume: 30 Issue: 3-4 Pages: 288-296

    • DOI

      10.1038/s41434-022-00357-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08262
  • [Journal Article] Anti-BlyS antibody reduces the immune reaction against enzyme and enhances the efficacy of enzyme replacement therapy in Fabry disease model mice.2017

    • Author(s)
      Sato Y, Ida H, Ohashi T
    • Journal Title

      Clin Immunol.

      Volume: 178 Pages: 56-63

    • DOI

      10.1016/j.clim.2017.01.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09600
  • [Journal Article] GALC transduction leads to morphological improvement of the twitcher oligodendrocytes in vivo.2005

    • Author(s)
      Meng XL, Shen JS, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      Mol Genet Metab. (in press)

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Widespread and highly persistent gene transfer to the CNS by retrovirus vector in utero : Implication for gene therapy to Krabbe disease.2005

    • Author(s)
      Shen JS, Meng XL, Yokoo T, Sakurai K, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] GALC transduction leads to morphological improvement of the twitcher oligodendrocytes in vivo.2005

    • Author(s)
      Meng XL, Shen JS, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      Mol Genet Metab. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Widespread and highly persistent gene transfer to the CNS by retrovirus vector in utero : Implication for gene therapy to Krabbe disease.2005

    • Author(s)
      Shen JS, Meng XL, Yokoo T, Sakurai K, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] GALC transduction leads to morphological improvement of the twitcher oligodendrocytes in vivo.2005

    • Author(s)
      Meng X-L, Shen J-S, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      Mol Gene Metab 84

      Pages: 332-343

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570627
  • [Journal Article] 最新の遺伝子治療診断と治療 Gaucher病の遺伝子変異2005

    • Author(s)
      大橋十也
    • Journal Title

      日本臨床 63(3)

      Pages: 498-500

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Widespread and highly persistent gene transfer to the CNS by retrovirus vector in utero : Implication for gene therapy to Krabbe disease.2005

    • Author(s)
      Shen JS, Meng XL, Yokoo T, Sakurai K, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med (in press)

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Widespread gene transduction to the central nervous system by adenovirus in utero : Implication for prenatal gene therapy to brain involvement of lysosomal storage disease.2004

    • Author(s)
      Shen JS, Meng XL, Maeda H, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med. 6(11)

      Pages: 1206-1215

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Brain transplantation of genetically modified bone marrow stromal cells corrects CNS pathology and cognitive function in MPS VII mice.2004

    • Author(s)
      Sakurai K, Iizuka S, Shen JS, Meng XL, Mori T, Umezawa A, Ohashi T, Eto Y
    • Journal Title

      Gene Ther 11(19)

      Pages: 1475-1481

    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Brain transplantation of genetically modified bone marrow stromal cells corrects CNS pathology and cognitive function in MPS VII mice.2004

    • Author(s)
      Sakurai K, Iizuka S, Shen JS, Meng XL, Mori T, Umezawa A, Ohashi T, Eto Y
    • Journal Title

      Gene Ther 11(19)

      Pages: 1475-1481

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Treatment of lysosomal storage disorders : Cell therapy and gene therapy.2004

    • Author(s)
      Eto Y, Shen JS, Meng XL, Ohashi T.
    • Journal Title

      J Inherit Metab Dis. 27(3)

      Pages: 411-415

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Widespread gene transduction to the central nervous system by adenovirus in utero : Implication for prenatal gene therapy to brain involvement of lysosomal storage disease.2004

    • Author(s)
      Shen JS, Meng XL, Maeda H, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med 6(11)

      Pages: 1206-1215

    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Widespread gene transduction to the central nervous system by adenovirus in utero : Implication for prenatal gene therapy to brain involvement of lysosomal storage disease.2004

    • Author(s)
      Shen JS, Meng XL, Maeda H, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med 6(11)

      Pages: 1206-1215

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Treatment of lysosomal storage disorders : Cell therapy and gene therapy.2004

    • Author(s)
      Eto Y, Shen JS, Meng XL, Ohashi T.
    • Journal Title

      J Inherit Metab Dis. 27(3)

      Pages: 411-415

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Brain transplantation of genetically modified bone marrow stromal cells corrcts CNS pathology and cognitive function in MPS VII mice.2004

    • Author(s)
      Sakurai K, Iizuka S, Shen JS, Meng XL, ori_T, _Umezawa A, Ohashi T, Eto Y
    • Journal Title

      Gene Ther 11(19)

      Pages: 1475-1481

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Widespread gene transduction to the central nervous system by adenovirus in utero : Implication for prenatal gene therapy to brain involvement of lysosomal storage disease2004

    • Author(s)
      Shen JS, Meng XL, Maeda H, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med 6(11)

      Pages: 1206-1215

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Brain transplantation of genetically modified bone marrow stromal cells corrects CNS pathology and cognitive function in MPS VII mice.2004

    • Author(s)
      Sakurai K, Iizuka S, Shen JS, Meng XL, Mori T, Umezawa A, Ohashi T, Eto Y.
    • Journal Title

      Gene Ther. 11(19)

      Pages: 1475-1481

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Adenoviral gene transfer of GDNF, BDNF and TGFβ2, but not CNTF, cardiotrophin-1 or IGF1, protects injured adult motoneurons after facial nerve avulsion.2003

    • Author(s)
      Sakamoto T, Kawazoe Y, Shen J-S, Takeda Y, Arakawa Y, Ogawa J, Oyanagi K, Ohashi T, Watanabe K, Inoue K, Eto Y, Watabe K.
    • Journal Title

      J Neurosci Res 72

      Pages: 54-64

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570627
  • [Journal Article] Braintransplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis type VII mouse.2003

    • Author(s)
      Meng XL, Shen JS, Ohashi T, Maeda H, Kim SU, Eto Y.
    • Journal Title

      J Neurosci Res. 74(2)

      Pages: 266-277

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils.2003

    • Author(s)
      Hakuba N, Watabe K, Hyodo J, Ohashi T, Eto Y, Taniguchi M, Yang L, Tanaka J, Hata R, Gyo K.
    • Journal Title

      Gene Ther 10

      Pages: 426-433

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570627
  • [Journal Article] Establishment and characterization of spontaneously immortalized Schwann cells from murine model of globoid cell leukodystrophy (Twitcher).2002

    • Author(s)
      Shen J-S, Watabe K, Meng XL, Ida H, Ohashi T, Eto Y.
    • Journal Title

      J Neurosci Res 68

      Pages: 588-594

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570627
  • [Journal Article] Widespread and highly persistent gene transfer to the CNS by retrovirus vector in utero : Implication for gene therapy to Krabbe disease.

    • Author(s)
      Shen J-S, Meng X-L, Yokoo T, Sakurai K, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570627
  • [Presentation] Application of a novel murine model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy2022

    • Author(s)
      Shimada Y, Ishii N, Higuchi T, Goto M, Ohashi T, Kobayashi H
    • Organizer
      25th Annual Meeting of The American Society of Gene and Cell Therapy
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08262
  • [Presentation] Analysis of human hematopoietic stem cell gene therapy using mucopolysaccharidosis type II mice2021

    • Author(s)
      Shimada Y, Ishii N, Higuchi T, Ohashi T, Kobayashi H
    • Organizer
      第62回日本先天代謝異常学会
    • Data Source
      KAKENHI-PROJECT-19K08262
  • [Presentation] MPS II型もdルマウス脳病変における、免疫寛容導入療法併用大量酵素補充療法の効果2017

    • Author(s)
      横井健太郎、横井貴之、嶋田洋太、樋口孝、小林博司、大橋十也、井田博幸
    • Organizer
      日本先天代謝異常学会
    • Data Source
      KAKENHI-PROJECT-15K09600
  • [Presentation] 免疫寛容導入による効果的ポンペ病酵素補充療法の開発

    • Author(s)
      大橋十也 嶋田洋太 樋口孝 飯塚佐代子 井田博幸 衞藤義勝 小林博司
    • Organizer
      第56回日本先天代謝異常学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-13 – 2014-11-15
    • Data Source
      KAKENHI-PROJECT-24591526
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  • 2.  ETO Y. (50056909)
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  • 3.  HASEGAWA Yoriyasu (60256435)
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    # of Collaborated Projects: 3 results
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  • 15.  KAWAME H. (60246395)
    # of Collaborated Projects: 2 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 19.  小林 正久 (20312019)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 20.  MAEDA Kazuhiro (50548849)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  KUROSAWA Kenji (20277031)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  TANAKA T (50110929)
    # of Collaborated Projects: 1 results
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  • 23.  OKAMOTO Aikou (20204026)
    # of Collaborated Projects: 1 results
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  • 24.  GOMIBUCHI Ichizou (50205621)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  KAWANO Hitoshi (20161341)
    # of Collaborated Projects: 1 results
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  • 26.  SANGO Kazunori (50291943)
    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 29.  TADA Yuki (10179707)
    # of Collaborated Projects: 1 results
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  • 30.  TAHARA Takahiro (80159029)
    # of Collaborated Projects: 1 results
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