Matsubayashi Hiroaki 松林弘明

… Alternative Names

MATSUBAYASHI Hiroaki 松林弘明

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Researcher Number	60165850
External Links
Affiliation (Current)	2025: 広島工業大学, 工学部, 教授
Affiliation (based on the past Project Information) *help	2006 – 2007: 広島工業大学, 情報学部, 教授 2003 – 2005: Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 2002: 広島大学, 大学院・医歯薬学総合研究科, 講師 1998 – 2001: 広島大学, 医学部, 講師 1999: 広島大学, 医学部, 教授 … More 1996 – 1997: 広島大学, 医学部, 助手 1993 – 1994: Research Associate, Hiroshima University School of Medicine, 医学部, 助手 1986: Hiroshima University School of Medicine, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology Except Principal Investigator 内科学一般 / 応用薬理学・医療系薬学 / General pharmacology / Biological Sciences / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator RT-PCR / ion channel / PLC activity / microglia / nicotinic receptor / PKC / 細胞内カルシウム / イオンチャネル / PLC活性化 / ミクログリア … More / ニコチン受容体 / nicotinic acetylcholine receptor / patch clamp / nicotine / striato-nigral dopamine pathway / ニコチン性アセチルコリン受容体 / パッチクランプ法 / ニコチン / 黒質線条体ドパミン系 … More Except Principal Investigator トランスジェニックマウス / プロテインキナーゼC / カルシウムチャネル / Ca^<2+> channel / トレモアラット / リン酸化 / 神経可塑性 / GABA / 個体発生 / Autoradiography / 神経伝達物質受容体 / transgenic mice / 神経興奮伝播 / PDK-1 / SER / 自然発症てんかんラット(SER) / CNK-602A / Absence-like seizure / 自然発症てんかんラット / 欠神様発作 / ライブイメージング / 小脳プルキンエ細胞 / 蛋白質リン酸化 / Neurogenerative disorder / Standard / Quantitative analysis / invitro Autoradiography / Neutotransmitter receptor / 画像解析 / Unnerstallの式 / 標準曲線 / オートラジオグラフィー / 神経伝達物質受容体の絶対数 / 各種変性性神経疾患剖検脳 / 受容体の絶対数 / In vitro autoradiography / 変性性神経疾患 / standard / 定量的解析 / in vitro オートラジオグラフィー / 脳内神経伝達物質受容体 / acetylcholine / dopamine / rat / monkey / substantia nigra / basal ganglia / 免疫電顕法 / グルタミン酸脱炭酸酵素 / サブスタンスP / エンケファリン / チロシン水酸化酵素 / アセチルコリン / 神経ペプチド / ドパミン / ラット / 猿 / 黒質 / 大脳基底核 / Radioreceptor assay / Ontogeny / Autopsied human brains of neurodegenerative disorders / Neurotransmitter receptors / 個体発生学的変化 / autoradiography / 受容体結合実験 / 変性性神経疾患剖検脳 / Propagation on neuronal excitation / Purkinje cell / protein kinase C / protein phosphorylation / プルキンエ細胞 / propagation of neural excitability / protein kinase C (PKC) / phosphorylation / GABA_A receptor / metabotropic glutamate receptor / N-acetyl aspartate / aspartoacetylase gene / epileptic seizure / tremor rat / ASP遺伝子 / パッチクランプ / 海馬CA3ニューロン / アスパルトアセチレース / パッチクランプ法 / N-アセチルアスパルテート / GABA_A受容体 / Ca^<2+>チャネル / 代謝型グルタミン酸受容体 / N-アセチルアスパルテート(NAA) / アスパルトアセチレース遺伝子 / てんかん発作 / tm gene / spontaneously epileptic rat (SER) / nifedipine / aspartpacetylase / calcium influx / hippocampal CA3 / fura / CaィイD12+ィエD1 channel / Syb2 / 海馬CA3細胞 / グルタミン酸 / パッチクランプホールセル記録 / トピラメート / Fura2-AM / ホールセルパッチクランプ / カルシウム電流 / ニカルジピン / tm因子 / ニフェジピン / アスパルトアセチラーゼ / カルシウム流入 / 海馬CA3 / fura2 / Ca^<2+> channel abnormality / depolarization shift / high-amplitude spike / autosomal recessive gene / audiogenic seizure / acoustic priming / epileptic model animal / Noda epileptic rat (NER) / 高電位棘波群発 / 強直-間代性けいれん / 音誘発発作 / 高振幅スパイク / ノダてんかんラット(NER) / Ca^<2+>チャネル異常 / 脱分極シフト / 音振幅スパイク / 常染色体劣性遺伝 / 聴原性発作 / 音刺激プライミング / てんかんモデル動物 / ノダてんかんラット / Ca^<2+> antagonist / TRH analogue / Tonic convulsion / Spontaneously epileptic rats / チッターラット / 遺伝子解析 / 発作自動記録 / カルシウム拮抗薬 / TRH類緑体 / 強直性けいれん / Hippocampal pyramidal cell / Antiepileptics / Spontaneously epileptic rat(SER) / Tremor rat / TRH / カルシウムイオンチャンネル / 海馬錐体細胞 / 抗てんかん薬 / Receptor-receptor interaction / イノシトールリン脂質代謝 / ラット海馬 / Somatostatin / Muscarinic acetylcholine receptor / 神経変性疾患 / 凝集体 / Tet制御システム / プイロテインキナーゼC Less

The study for new regulating mechanism of neuronal nicotinic acetylcholine receptor and the development of new therapeutics for psycho-neurological disordersPrincipal Investigator
- Principal Investigator
  
  MATSUBAYASHI Hiroaki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima Institute of Technology
変異PKCによる神経変性疾患の病因解明 -ターゲティングを指標にした解析-
- Principal Investigator
  
  酒井規雄
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
Functional analysis of protein kinase C(PKC), a molecule involved in plasticity, development and cell death in central nervous system, using gene-manipulated mice.
- Principal Investigator
  
  SAKAI Norio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  HIROSHIMA UNIVERSITY
Roles of protein kinase C (PKC) in the formation of neural plasticity. -Investigation using GFP-tagged PKC
- Principal Investigator
  
  SAKAI Norio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  HIROSHIMA UNIVERSITY
神経可塑性制御に対するPKCの役割-トランスジェニックマウスを用いた研究-
- Principal Investigator
  
  SAKAI Norio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hiroshima University
  Kobe University
Pharmacological research on Ca^<2+> channel abnormality which induces epileptic seizures
- Principal Investigator
  
  SASA Masashi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  HIROSHIMA UNIVERSITY
Functional role of nicotinic receptor in striato-nigral dopaminergic pathway using patch clamp method.Principal Investigator
- Principal Investigator
  
  MATSUBAYASHI Hiroaki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima University
Pharmacological research on CaィイD12+ィエD1 channel abnormality which induces epileptic seizures.
- Principal Investigator
  
  SASA Masashi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima University
Development and pharmacological application of a newly genetic epilepsy rat (NER)
- Principal Investigator
  
  SASA Masahi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HIROSHIMA UNIVERSITY
Production under control of microorganism and pharmacological use of spontaneously epileptic rats.
- Principal Investigator
  
  SASA Masashi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HIROSHIMA UNIVERSITY
Establishment of newly found tremor rat as absence seizure model and pharmacological usefulness
- Principal Investigator
  
  SASA Masashi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HIROSHIMA UNIVERSITY
アセチルコリン-ソマトスタチン相互関連に関する受容体学的研究
- Principal Investigator
  
  KITO Shozo
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Hiroshima University
Interrelationships of neurotransmitters in the basal ganglia of the rat and monkey - in reference to the extrapyramidal disease.
- Principal Investigator
  
  INAGAKI Shinobu
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  HIROSHIMA UNIVERSITY
Establishment of a method how to calculate the absolute number of neurotransmitter receptors acuroadiogaphically imaged
- Principal Investigator
  
  KITO Shozo
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  内科学一般
- Research Institution
  HIROSHIMA UNIVERSITY
Neuronal plasticity as investigated from a viewpoint of receptor research
- Principal Investigator
  
  KITO Shozo
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  HIROSHIMA UNIVERSITY

All 2008 2004

All Journal Article Presentation

[Journal Article] Involvement of α7 and α4β2 type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra : A patch clamp and single-cell PCR study using acutely dissociated nigral neurons.2004
- Author(s)
  Matsubayashi, H.
- Journal Title
  
  Mol. Brain Res. 129
  
  Pages: 1-7
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16500243
[Journal Article] Involvement of α7 and α4β2 type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra : A patch clamp and single-cell PCR study using acutely dissociated nigral neurons.2004
- Author(s)
  Matsubayashi, H.
- Journal Title
  
  Mol.Brain Res. 129
  
  Pages: 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500243
[Journal Article] Involvement of α7 and α4β2 postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in substantia nigra : A patch clamp and single-cell PCR study using acutely dissociated nigral neurons.2004
- Author(s)
  Matsubayashi, H.
- Journal Title
  
  Mol.Brain Research 129
  
  Pages: 1-7
- Data Source
  KAKENHI-PROJECT-16500243
[Journal Article] Postsynaptic α4β2 and α7 type nicotinic acetylcholine receptors (nAChRs) contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons.2004
- Author(s)
  Matsubayashi, H.
- Journal Title
  
  Brain Res. 1005
  
  Pages: 1-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16500243
[Journal Article] Involvement of α7 and α4β2 postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in substantia nigra : A patch clamp and single-cell PCR study using acutely dissociated nigral neurons.2004
- Author(s)
  Matsubayashi, H.
- Journal Title
  
  Mol.Brain Research 129
  
  Pages: 1-7
- Data Source
  KAKENHI-PROJECT-16015285
[Journal Article] Postsynaptic α4β2 and α7 typenicotinic acetylcholine receptors (nAChRs) contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons.2004
- Author(s)
  Matsubayashi, H.
- Journal Title
  
  Brain Res. 1005
  
  Pages: 1-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16500243
[Presentation] Alpha 7 nicotinic acetylcholine receptor signaling and modulation of cytokine production in microglia.2008
- Author(s)
  Hide I., Harada K., Matsubayashi H., Sakai N., Nakata Y.
- Organizer
  USA-JAPAN joint meeting for Glial Research
- Place of Presentation
  Philadelphia, U. S. A
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590234
[Presentation] Alpha7 nicotinic acetylcholine receptor signaling and modulation of cytokine production in microglia2008
- Author(s)
  Hide I., Harada K., Matsubayashi H., Sakai N., Nakata Y.
- Organizer
  USA-JAPAN joint meeting for Glial Research
- Place of Presentation
  アメリカ合衆国フィラデルフィア市
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590234

1. SASA Masashi (20025654)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. SERIKAWA Tadao (30025655)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. AMANO Taku (10294547)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. SAKAI Norio (70263407)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. KITO Shozo (00010140)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. INAGAKI Shinobu (90151571)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. ISHIHARA Kumatoshi (20212912)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. SEKI Takahiro (50335650)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. SHIMOYAMA Masanori (60136067)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. YAMAMURA Yasuhiro (10106388)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. UJIHARA Hisamitsu (00213421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KOHNO Shizuko (30034028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 白井康仁 (60263399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 斎藤尚亮 (60178499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山田淳三 (90025651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YAMAMOTO Toshiyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NODA Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Matsubayashi Hiroaki 松林 弘明

MATSUBAYASHI Hiroaki 松林 弘明

Research Projects

Research Products

Co-Researchers

The study for new regulating mechanism of neuronal nicotinic acetylcholine receptor and the development of new therapeutics for psycho-neurological disordersPrincipal Investigator

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Functional role of nicotinic receptor in striato-nigral dopaminergic pathway using patch clamp method.Principal Investigator

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Matsubayashi Hiroaki 松林弘明

MATSUBAYASHI Hiroaki 松林弘明