Ishizuka Tadao 石塚忠男

… Alternative Names

ISHIZUKA Tadao 石塚忠男

ISHIZUKA Todao 石塚忠夫

石塚忠男

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Researcher Number	60176203
Other IDs
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Affiliation (based on the past Project Information) *help	2019 – 2021: 熊本大学, 大学院生命科学研究部(薬), 教授 2009 – 2011: Kumamoto University, 大学院・生命科学研究部, 教授 2002 – 2005: Kumamoto University, Graduate School of Medical and Pharmaceutical Sciences, Associate Professor, 大学院・医学薬学研究部, 助教授 1995 – 2002: 熊本大学, 薬学部, 助教授 1996: 熊本大学, 薬学部・, 助教授 … More 1995: 熊本大学. 薬学部, 助教授 1989 – 1994: 熊本大学, 薬学部, 助手 1986 – 1988: 熊本大学, 薬学部, 教務員 Less
Review Section/Research Field	Principal Investigator Chemical pharmacy / Chemical pharmacy / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Chemical pharmacy / 医薬分子機能学 / Biological pharmacy / Biological pharmacy
Keywords	Principal Investigator 不斉合成 / 不斉補助剤 / ジアミン / 1,2-ジアミン / 2-イミダゾリジノン / 2-イミダゾロン / ビシクロ / チアゾリウム塩 / NHC / ビシクロ環 … More / チアゾリウム / カルベン / Amino alcohol / Diamine / Polymer / Asymmetric synthesis / Moleculary Imprinting / 不斉触媒 / アミノアルコール / ポリマー / 不斉認識 / モレキュラーインプリンティング / Chiral synthesis / Chiral auxiliary / Optical resolution / 1,2-Diamine / 2-Imidazolidinone / 2-Imidazolone / 光学分割 / 1、2-ジアミン / 合成子 / imidazolidinone / imidazolone / diamine / 有機化学 / イミダゾリジン / 2-オキサゾロン / 2-オキサゾリジノン / 2-アミノアルコール / 不斎補助剤 / 不斎合成 … More Except Principal Investigator 不斉補助剤 / 2-オキサゾロン / 2-オキサゾリジノン / 2-Oxazolidinone / 2-Oxazolone / アミノアルコール / 2-アミノアルコール / CD36 / 2-Imidazolidinone / 2-イミダゾリジノン / キラル合成子 / 2-Imidazolone / 2-イミダゾロン / Chiral auxiliary / Asymmetric synthesis / スタチン / 不斉配位子 / スカベンジャー受容体 / 2-Amino alcohol / 光学分割 / 不斉還元 / 不斉合成 / 不斉Diels-Alder反応 / 2-チアゾリン / 水素移動型不斉還元 / 不斉アルキル化 / scavenger receptors / Kinetic Resolution / Chiral Ligands / Chiral Auxiliaries / 人工不斉源 / 速度論的光学分割 / cholesterol metabolism / macrophage / glibenclamide / コレステロール代謝 / ACAT / マクロファージ / グリベンクラミド / スルホニルウレア / Chiral synthesis / 1、2-ジアミン / drug design / new compounds / drug binding site / photoaffinity labeling / 精密合成化学 / ドラッグデザイン / 新規化合物 / 薬物結合部位 / 光アフィニティラベリング / Ca拮抗薬 / Chiral Synthesis / Statine / 水酸化グルタミン酸 / リン酸化試薬 / ラジカル環化反応 / メソ型環状ジカルボン酸無水物 / 1,4-付加反応 / イミダゾリジノン / オキサゾリジノン / ウラシル光二量化 / Diels-Alder反応 / 液晶反応場 / Mixed phosphotriester / Beta-Latam / Hydroxy-glutamic acid / Amino alcohol / Chiral synthon / テロメリ化反応 / 生理活性アミノアルコール / 合成試薬 / 混合リン酸トリエステル / β-ラクタム / clearance / β-amyloid peptide / Alzheimer's disease / microglia / adipocytes / CD3b / 脳虚血 / ACAT阻害剤 / Aβクリアランス / 肥満 / クリアランス / β-アミロイドペプチド / アルツハイマー病 / ミクログリア / 脂肪細胞 / Asymmetric Diels-Alder reaction / 2-Thiazoline / Asymmetric transfer hydrogenation / Asymmetric alkylation / Kinetic resolution / 2-Thiazolidinone / アミノチオール / ジアミン / 2-チアゾロン / 屋根付不斉源 / 水素移動型不還元 / 2-チアゾリジノン / 触媒的光学分割 / Orientation regulation / Mitsunobu reaction / Intermolecular cycloaddition / Intramolecular cycloaddition / cholesteric phase / Smectic phase / Liquid crystal / 不斉触媒反応 / 不均斉化 / 不斉脱アセチル化 / スメクチック相 / ラジカル付加 / セレノメトキシ化 / ブロモメトキシ化 / 複素五員環化合物 / 不斉機能化 / 熱環化反応 / コレステリック液晶 / スメクチック液晶 / 光延反応 / 分子間環化反応 / 分子内環化反応 / コレスレリック液晶 / スメクチック結晶 / 分子配向制御 / 液晶 / ACAT inhibitors / sulfonylurea / ACAT阻害作用 / Bis(oxazoline) ligand / 不斉モノ脱アシル化 / メソ体 / オキサザボロリジン / ビスオキサゾリン / 不斉反応試薬 / 不斉制御能 / atherosclerosis / sulfonylureas / 光アフィニティラベル / 動脈硬化 / structural biology / Calcium antagonist / 薬理活性 / 抗ペプチド抗体 / 心筋Caチャンネル / 構造生物学 / 光アフィニティラベリング / aldol反応 / Michael反応 / Aldol反応 / synthesic chemistry / cardiac calcium channel / calcium antagonist / ベンゾチアゼピン化合物 / ジヒドロピリジン化合物 / 抗リガンド抗体 / 心筋L型Caチャンネル / Asymmetric reduction / Hydroxy amino acid / アルドール反応 / 水酸化アミノ酸 / オキサゾロン / Condensing reagent / 2-Amino alchol / チオリン酸 / 2ーオキサゾリドン / 2ーオキサゾロン / 2ーアミノアルコ-ル / 縮合剤 / 機能性液晶 / 高選択的高効率反応 / 親ジエンコレステック液晶 / ステアリン酸ブチルエステル / 液晶媒体 / β-ラクタム合成試薬 / キラル補助剤 / ヒスチジン / アミノ酸のDNP誘導体 / 高分解能FABーMS / 逆相中圧カラムクロマトグラフィ- / 多孔性合成吸着剤 / 抗カビ抗生物質 / ペプチド抗生物質 / ヒスチジノマイシン / マクロライド / 3連続不斉中心 / 立体選択的制御 / 位置選択的制御 / DielsーAlder反応 / 液晶親ジエン剤 / 液晶ジエノフィル / 光2量化反応 / 反応制御 / 合成子 / ベスタチン / ケトピン酸 / 2-アミノアルコ-ル Less

Study on the control of reactivity of thiazolinylidene NHCs by effective shielding by bicyclo-skeletonPrincipal Investigator
- Principal Investigator
  
  Ishizuka Tadao
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kumamoto University
Development of versatile 1, 2-Diamine synthetic methodology and its application for preparation of drug candidates.Principal Investigator
- Principal Investigator
  
  ISHIZUKA Tadao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Investigation of molecular mechanisms for common diseases caused by aging and oxidative stress and development of drug candidates aiming the molecular targets
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
Asymmetric reactions controled with moleculary imprinted polymers.Principal Investigator
- Principal Investigator
  
  ISHIZUKA Tadao
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Liquid Crystal Control of uni-to multi-molecular Thermal Reactions
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Highly efficient asymmetric synthesis process directed for optically pure medicines
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Development of novel anti-atheroscleroic agents
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
複素環系不斉補助剤を基盤とした精密な不斉制御空間の構築と不斉触媒反応への展開
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Investigation of Novel Function and Its Relation to Diseases for New Taget Proteins to Which Sulfonylureas Bind
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Chiral Processes towards Effective Synthesis of Optically Active Drugs
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
ラジカル環化反応を鍵とする多連続不斉中心構造の効率構築法の開発
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Development of the 4th generation calcium antagonists based on molecular revealing the binding sites in calcium channels
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Development of versatile synthetic route for 1,2-diamines as excellent chiral auxiliary.Principal Investigator
- Principal Investigator
  
  ISHIZUKA Tadao
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
2-イミダゾロンを構築材とした高性能1、2-ジアミン系不斉補助剤の開発Principal Investigator
- Principal Investigator
  
  石塚忠男
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Chemical identification of the binding sites for calcium antagonists in cardiac calcium channels and its application to developing new drugs
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
Highly Effective Chirality Controlling Systems.
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Development of Efficient Chiral Synthetic Process of Bioactive Compounds.
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
高性能不斉補助剤の開発と応用
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
高性能不斉補助剤の開発と応用
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
高性能不斉補助剤の開発と応用
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
高効率不斎反応場の構築Principal Investigator
- Principal Investigator
  
  石塚忠男
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
Asymmetric Synthesis and Molecular Design of Peptidic Renin Inhibitors
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Development of Novel Chiral Synthons for 2-Amino Alcohols of Biological Interest.
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University.
液晶構造に基づく高選択的高効率化学変換反応の設計
- Principal Investigator
  
  国枝武久
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
複素環骨格の反応特性を利用する生理活性物質合成
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University
液晶を反応の場とする高選択的・高効率化学変換反応
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
高い抗カビ活性をもつ新ペプチド抗生物質ヒスチジノマイシンの精製法の改良と構造解析
- Principal Investigator
  
  金田幸, 國枝武久
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Hiroshima University
  Kumamoto University
液晶を反応の場とする高選択的高効率化学変換反応
- Principal Investigator
  
  國枝武久
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
多官能性汎用合成素子の開発と生理活性物質合成への応用
- Principal Investigator
  
  国枝武久
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kumamoto University
Facile Synthesis of Bioactive Amino Alcohols Utilizing 2-Oxazolone Heterocycle
- Principal Investigator
  
  KUNIEDA Takehisa
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kumamoto University

All 2020 2012 2011 2010 2004

All Journal Article Presentation

[Journal Article] Analyses of the Structural and Electronic Properties of NHCs with Bicyclic Architectures2020
- Author(s)
  Ando Shin、Otsuka Mio、Ishizuka Tadao
- Journal Title
  
  Organometallics
  
  Volume: 39 Issue: 21 Pages: 3839-3848
- DOI
  10.1021/acs.organomet.0c00564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06998, KAKENHI-PROJECT-18K06583
[Journal Article] A Simple, Iron-catalyzed, Pyridine-assisted Hydrogen Peroxide Epoxidation System2011
- Author(s)
  Mingyu Jiao, Hirofumi Matsunaga, Tadao Ishizuka
- Journal Title
  
  Chemical & Pharmaceutical Bulletin
  
  Volume: 59(in press)
- NAID
  130000748013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590013
[Journal Article] A Simple, Iron-catalyzed, Pyridineassisted Hydrogen Peroxide Epoxidation System2011
- Author(s)
  Mingyu, J., Matsunaga, H., Ishizuka, T.
- Journal Title
  
  Chemical & Pharmaceutical Bulletin
  
  Volume: vol.59 Pages: 799-801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590013
[Journal Article] Sterically congested,"roofed"υ-iminodisulfides as new chiral ligands for palladium-catalyzed, asymmetric allylic alkylation2010
- Author(s)
  Matsunaga, H., Tokuda, R., Nakajima, M., Ishizuka, T.
- Journal Title
  
  Chemical & Pharmaceutical Bulletin
  
  Volume: vol.58 Pages: 1419-1421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590013
[Journal Article] Sterically congested, "roofed". beta.-iminodisulfides as new chiral ligands for palladium-catalyzed,asymmetric allylic alkylation.2010
- Author(s)
  Matsunaga, Hirofumi; Tokuda, Ryoh; Nakajima, Makoto; Ishizuka, Tadao.
- Journal Title
  
  Chemical & Pharmaceutical Bulletin
  
  Volume: 58 Pages: 1419-1421
- NAID
  130000405652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590013
[Journal Article] Catalytic dissymmetrization of meso-2-imidazolidinones : alternative route to chiral synthons for 1,2-diamines2004
- Author(s)
  Tadao Ishizuka
- Journal Title
  
  Tetrahedron Letters 45
  
  Pages: 9327-9330
- Data Source
  KAKENHI-PROJECT-15590013
[Journal Article] Catalytic dissymmetrization of meso-2-imidazolidinones : alternative route to chiral cynthons for 1,2-diamines2004
- Author(s)
  Ishizuka, T.
- Journal Title
  
  Tetrahedron Letters 45
  
  Pages: 9327-9330
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590013
[Journal Article] Catalytic dissymmetrization of meso-2-imidazolidinones : alternative route to chiral cynthons for 1,2-diamines2004
- Author(s)
  Ishizuka, T. et al.
- Journal Title
  
  Tetrahedron Letters 45
  
  Pages: 9327-9330
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590013
[Presentation] 鉄触媒酸化反応を利用した1, 2-ジアミンキラルシントン合成法の開発2012
- Author(s)
  江下伊織、松永浩文、石塚忠男
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21590013
[Presentation] 不斉酸化反応を用いた1, 2-ジアミン類キラルシントン効率合成法の開発と応用2011
- Author(s)
  江下伊織、松永浩文、石塚忠男
- Organizer
  第41回複素環化学討論会
- Place of Presentation
  崇城大学市民ホール
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-21590013

1. KUNIEDA Takehisa (80012649)

# of Collaborated Projects: 19 results

# of Collaborated Products: 0 results
2. MATSUNAGA Hirohumi (10274713)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. NAKAYAMA Hitoshi (70088863)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. KUNIYASU Akihiko (90241348)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. NAGAMATSU Tomohisa (40155966)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. MIYAZAKI Akira (70253721)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. HARADA Kumiko (70150547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAYAMA Morio (60164373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAWANO Seiko (00177718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KAI Hirofumi (30194658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAWAHARA Kohichi (10347015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SAKUMA Yoshiharu (70040318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 金田幸 (40019675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中村昭四郎 (40013304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 豊島近 (70172210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAKAMURA Norio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NABATA Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OHZEKI Masakatsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. SANNO-HE Kunio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. NISHI Takao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ARITA Masafumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Ishizuka Tadao 石塚 忠男

ISHIZUKA Tadao 石塚 忠男

ISHIZUKA Todao 石塚 忠夫

石塚 忠男

Research Projects

Research Products

Co-Researchers

Study on the control of reactivity of thiazolinylidene NHCs by effective shielding by bicyclo-skeletonPrincipal Investigator

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Development of versatile 1, 2-Diamine synthetic methodology and its application for preparation of drug candidates.Principal Investigator

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Asymmetric reactions controled with moleculary imprinted polymers.Principal Investigator

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Development of versatile synthetic route for 1,2-diamines as excellent chiral auxiliary.Principal Investigator

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2-イミダゾロンを構築材とした高性能1、2-ジアミン系不斉補助剤の開発Principal Investigator

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Ishizuka Tadao 石塚忠男

ISHIZUKA Tadao 石塚忠男

ISHIZUKA Todao 石塚忠夫

石塚忠男