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NISHIMURA Hiroyuki  西村 裕之

ORCIDConnect your ORCID iD *help
… Alternative Names

西村 裕之  ニシムラ ヒロユキ

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Researcher Number 60189313
Other IDs
External Links
Affiliation (Current) 2025: 桐蔭横浜大学, 医用工学部, 教授
Affiliation (based on the past Project Information) *help 2017: 桐蔭横浜大学, 医用工学部, 教授
2011 – 2013: 桐蔭横浜大学, 医用工学部, 教授
2005 – 2008: Toin University of Yokohama, Professor, 医用工学部, 教授
2006: 桐蔭学園横浜大学, 工学部, 教授
2006: Toin Human Science and Technology Center, Toin University of Yokohama, 人間科学セ, 教授 … More
1998 – 2005: 桐蔭横浜大学, 工学部, 教授
2001: Department of Biomedical Enginee, Toin Human Science and Technolog Center, Toin University of Yokoh, Professor, 工学部, 教授
1999: 桐薩横浜大学, 工学部, 教授
1997: Human Science and Tecnology Center, Toin University of Yokohama, Professor, 工学部, 教授
1996: 桐蔭横浜大学, 人間科学・工学センター, 教授
1996: TOIN KHUMAN SCINCE AND TECHNOLOGY CENTER TOIN UNIVERSITY OF YOKOHAMA PROFESSOR, 工学部・材料工学科, 教授
1995: 桐蔭学院, 横浜大学・工学部, 教授
1994 – 1995: Toin Human Science and Technology Center, Toin University of Yokohama, 工学部・材料工学科, 教授
1994: 桐蔭学園横浜大学, 工学部, 教授
1993: 順天堂大学, 医学部, 助教授
1987 – 1989: 順天堂大学, 医学部, 助手
1988: 医学部, 第2病理, 助手 Less
Review Section/Research Field
Principal Investigator
Immunology / Pathological medical chemistry / 内科学一般 / 膠原病・アレルギー・感染症内科学
Except Principal Investigator
Experimental pathology / 膠原病・アレルギー・感染症内科学 / Experimental pathology / Immunology / Biomedical engineering/Biological material science / Biomedical engineering/Biological material science
Keywords
Principal Investigator
SLE / CD69 / NZB mice / 自己免疫疾患 / 全身性エリテマトーデス / Th2 / Th1 / CD4陽性T細胞 / 全身性自己免疫疾患 / New Zealand系マウス … More / 連鎖解析 / NZW系マウス / NZB系マウス / alternative splicing / CD45R / CD45 / NZW mice / 免疫寛容 / 遺伝連鎖解析 / 疾患感受性遺伝子 / Fc receptor / genetic linkage study / disease susceptibility gene / systemic lupus erythematosus / autoimmune disease / immune tolerance / ゲノムマッピング / 疾患感受性 / ポリエチレングリコール / 免疫グロブリン / 6系マウス / C57BL / 遺伝支配 / Fc受容体 / CD4+Th cells / (NZB x NZW) F1 / New Zealand mice / systemic autoimmune diseases / 多因子病 / モデルマウス / Th細胞 / (NZB x NZW)F1マウス / (NZBxNZW) F1 / Systemic Lupus Erythematosus / Quantitative Trait Loci / リンパ球の活性化 / 主要組織適合遺伝子複合体 / Quantitative Trait Loci(QTL) / マイクロサテライトDNA / CD4陽性T細胞サブセット / 自発的活性化 / CD4+ T細胞 / (NZB x NZW)F1 / (NZB*NZW) F1 mice / activated T cells / CD4^+ T cells / (NZB×NZW)F1 / New Zealand マウス / 活性化 / (NZB×NZW)F1マウス / NZBマウス / 活性化T細胞 / lymphocyte subsets / differentiation of lymphocytes / B cells / CD8+ T cells / CD4+ T cells / CD4T細胞 / (NZB×N2W)F_1 / サイトカイン / CD45RC / サブセット / 分化 / B細胞 / CD8陽性T細胞 / 自己免役疾患 / MHC class II / FcgRIIB / Fcgr2b / 多因子疾患 / QTL解析 … More
Except Principal Investigator
SLE / 全身性エリテマトーデス / 自己免疫 / 自己免疫疾患 / QTL / Kj / SCG / MPO-ANCA / Autoimmunity / ポリエチレングリコール / 化学修飾 / autoimmune disease / トランスジェニックマウス / ループス腎炎 / 抗リン脂質抗体症候群 / 自己抗体 / 疾患感受性遺伝子 / New Zealandマウス / FcγRIIB / 胚中心 / 抑制性igG Fc受容体 / Yaa変異遺伝子 / リンパ濾胞胚中心 / 抑制性IgG Fc受容体 / 自己抗体産生B細胞 / RNA sequencing / 単球 / 細胞特異的遺伝子欠損 / Yaa / cDNA cloning / lymphokine receptor / monoclonal antibody / activated B cell / モノクロナール抗体 / アミノ酸配列分析 / ウエタンブロット / 免疫グロブリンス-パ-ジ-ンファミリ- / アフィニティフグロマトグラフィ / 増殖分化因子リセプタ- / B細胞亜集団 / 活性化B細胞抗原 / cDNAクロ-ニング / 増殖分化因子レセプタ- / モノクロ-ナル抗体 / 活性化B細胞 / New Zealand mouse / transgenic mouse / congenic mouse / TCR / MHC / 自己免疫遺伝子 / コンジェニックマウス / クラスII抗原 / Transgenicマウス / 全身性エリテマト-デス / New Aealandマウス / transgenicマウス / congenicマウス / 遺伝子組み換え / T細胞抗原受容体 / 主要組織適合遺伝子複合体 / 全身正エリテマト-デス / crescent / glomerulonephritis / vasculitis / 半月体 / 糸球体腎炎 / 血管炎 / Clearance time / Metabolism / Chemical modification / Protein / Biomaterial / Enzyme / コラーゲン関節炎 / スーパーオキシドジスムターゼ / タンパク質の化学修飾 / クリアランスタイム / 代謝 / タンパク質 / 生体材料 / 酵素 / Susceptibility genes / Multigeneic disease / Microsatellite / Genome screening / Genome / Genetics / 組織プラスミノーゲンアクチベーター遺伝子 / 遺伝子統御領域多型 / IgFc受容体IIB遺伝子 / 高IgG血症 / 高IgG抗体応答 / IgG遺伝子制御領域多型 / Fe受容体IIB遺伝子 / B細胞活性化 / 素因 / 疾患感受性 / 多因子病 / 多遺伝子病 / ゲノム解析 / pH-dipendency / heat stability / fructo-origosaccharide / β-fructofranosidase / stabilization / chemical modification / comb-shaped PEG / エンドグリコシダーゼH / インベルターゼ / 糖タンパク / 糖鎖除去酵素 / 糖鎖 / ポリエチレングリコール誘導体(PM) / pH依存症 / 耐熱性 / フルクトオリゴ糖 / β-フルクトフラノシダーゼ / 安定化 / 櫛状ポリエチレングリコール / New Zealand mice / mutigenic disease / modifier gene / microsatellite markers / gene interaction / disease susceptibility gene / 自己免疫性血小板減少症 / SLE素因遺伝子 / SLE(全身性エリテマトーデス) / Mott cell / マイクロサテライトDNA解析 / 血小板減少症 / 抗血小板抗体 / 抗カルヂオリピン抗体 / 遺伝子統御 / MHCハプロタイプ / B1細胞 / B-CLL / 多遺伝子疾患 / 修飾遺伝子 / マイクロサテライト解析 / 遺伝子間相互作用 / Akt / 樹状細胞 / Flt3 / Fc・RIIB / 樹上細胞 Less
  • Research Projects

    (14 results)
  • Research Products

    (55 results)
  • Co-Researchers

    (19 People)
  •  Role of FcgRIIB for autoantibody production inside and outside of germinal centers

    • Principal Investigator
      Hirose Sachiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Toin University of Yokohama
  •  Pathogenesis of SLE: Linkage Analysis of Critical Signaling PathwaysPrincipal Investigator

    • Principal Investigator
      NISHIMURA Hiroyuki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Toin University of Yokohama
  •  A novel regulatory role of IgG Fc receptor IIB in Flt3L-mediated dendritic cell development

    • Principal Investigator
      HIROSE Sachiko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Juntendo University
  •  Chemical modification of Profein Drugs with Polyethylene Glycol

    • Principal Investigator
      YOH Kodera
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Toin University of Yokohama
  •  Genetic dissection of MPO-ANCA related systemic vasculitis-prone SCG/Kj mice.

    • Principal Investigator
      HAMANO Yoshitomo
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      JUNTENDO UNIVERSITY
  •  Genetic control of the defective immune tolerance in systemic lupus erythematosus-prone New Zealand Black mice.Principal Investigator

    • Principal Investigator
      NISHIMURA Hiroyuki
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      TOIN HUMAN SCIENCE AND TECHNOLOGY CENTER, TOIN UNIVERSITY OF YOKOHAMA
  •  Genetic control of the spontaneous activation of CD4+ Th cells in systemic lupus erythematosus (SLE)-prone (NZB x NZW) F1 micePrincipal Investigator

    • Principal Investigator
      NISHIMURA Hiroyuki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Toin University of Yokohama
  •  Genetic factors Involved in the Pathogenesis of Autoimmune Disea

    • Principal Investigator
      SHIRAI Toshikazu
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      JUNTENDO UNIVERSITY
  •  Stabilization of carbohydrate-depleted invertase by modification with comb-shpaed poly(ethylene glycol) derivative.

    • Principal Investigator
      HIROTO Misao
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      UNIVERSITY OF YOKOHAMA
  •  Abnormal polarization of CD4^+ T cell subsets in autoimmune-Prone New Zealand mice.Principal Investigator

    • Principal Investigator
      NISHIMURA Hiroyuki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      TOIN UNIVERSITY OF YOKOHAMA TOIN HUMAN SCIENCE AND TECHNOLOGY CENTER
  •  Genetic polymorphism of SLE

    • Principal Investigator
      SHIRAI Toshikazu
    • Project Period (FY)
      1994 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Juntendo Univeristy
  •  Regulation of the Expression of CD45 alternative Structures in Lymphocyte SubsetsPrincipal Investigator

    • Principal Investigator
      NISHIMURA Hiroyuki
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Toin University of Yokohama
      Juntendo University
  •  Structure and function of Lp-3, an early activation antigen on murine B cells

    • Principal Investigator
      SATO Hidetoshi
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Juntendo University School of Medicine
  •  Studies of autoimmune disease using mice with genetic recombination

    • Principal Investigator
      SHIRAI Toshikazu
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Juntendo University

All 2018 2017 2016 2015 2014 2013 2012 2011 2008 2007 2006 2005

All Journal Article Presentation Book

  • [Book] Boihybrid Maaateeerial"特集 バイオハイブリッド研究と医学"2005

    • Author(s)
      稲田祐二, 西村裕之
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-15590282
  • [Journal Article] Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice.2018

    • Author(s)
      Ohtsuji M, Lin Q, Okazaki H, Takahashi K, Amano H, Yagita H, Nishimura H, and Hirose S.
    • Journal Title

      Arthritis Res. Ther.

      Volume: 20:25 Issue: 1 Pages: 1-11

    • DOI

      10.1186/s13075-018-1523-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08432, KAKENHI-PROJECT-16K09907
  • [Journal Article] A novel pathway of peripheral B cell tolerance breakdown induced by inhibitory IgG Fc receptor IIb-deficient monocytes.2018

    • Author(s)
      Lin Q, Ohtsuji M, Amano H, Tsurui H, Tada N, Sato R, Fukuyama H, Nishimura H, Verbeek JS, and Hirose S.
    • Journal Title

      J. Immunol.

      Volume: 印刷中

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Journal Article] IL-6 signal blockade ameliorates the enhanced osteoclastogenesis and the associated joint destruction in a novel FcγRIIB-deficient rheumatoid arthritis mouse model.2015

    • Author(s)
      Ohtsuji M, Lin Q, Nishikawa K, Ohtsuji N, Okazaki H, Tsurui H, Amano H, Shirai T, Nishimoto N, Nishimura H, and Hirose S.
    • Journal Title

      Mod. Rheumatol.

      Volume: 25 Issue: 2 Pages: 270-277

    • DOI

      10.3109/14397595.2014.950035

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-25330349, KAKENHI-PROJECT-15K08432
  • [Journal Article] Genome-wide genetic study in autoimmune disease-prone mice.2014

    • Author(s)
      Obata M, Ohtsuji M, Iida Y, Shirai T, Hirose S, Nishimura H
    • Journal Title

      Methods Mol Biol

      Volume: 1142 Pages: 111-41

    • DOI

      10.1007/978-1-4939-0404-4_13

    • ISBN
      9781493904037, 9781493904044
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Journal Article] TNFalpha but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcgammaRIIB-deficient mouse model.2014

    • Author(s)
      Okazaki H, Lin Q, Nishikawa K, Ohtsuji N, Tsurui H, Ohtsuji M, Amano H, Tada N, Sudo K, Nishimura H, Shirai T, Hirose S
    • Journal Title

      Mol Rheumatol

      Volume: Mar 4 Pages: 1-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Journal Article] Peripheral tolerance of antigen-specific Th cells induced with polyethylene glycol-conjugate of protein antigen.2013

    • Author(s)
      Obata M, Fujii T, Ohtsuji M, Kodera Y. Nishimura H.
    • Journal Title

      Open Journal of Immunology

      Volume: 3 Pages: 1-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Journal Article] Peripheral tolerance of antigen-specific Th cells induced with polyethylene glycol-conjugate of protein antigen2013

    • Author(s)
      Obata M, Fujii T, Ohtsuji M, Kodera Y, Nishimura H
    • Journal Title

      Open J Immunol

      Volume: 3 Pages: 62-70

    • Data Source
      KAKENHI-PROJECT-23591450
  • [Journal Article] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcgRIIB-deficient C57BL/62013

    • Author(s)
      Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H,Takai T, Shirai T, Takasaki Y and Hirose S
    • Journal Title

      mice.

      Volume: 43 Issue: 3 Pages: 770-778

    • DOI

      10.1002/eji.201243057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590194, KAKENHI-PROJECT-23591450, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-24659215, KAKENHI-PROJECT-25330349, KAKENHI-PROJECT-25461486
  • [Journal Article] Development of a model of early-onset IgA nephropathy.2012

    • Author(s)
      Okazaki K, Suzuki Y, Otsuji M, Suzuki H, Kihara M, Kajiyama T, Hashimoto A, Nishimura H, Brown R, Hall S, Novak J, Izui S, Hirose S, Tomino Y.
    • Journal Title

      J Am Soc Nephrol

      Volume: 23 Issue: 8 Pages: 2930-2938

    • DOI

      10.1681/asn.2011121160

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591450, KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-24591213
  • [Journal Article] Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcy receptor type Iib-deficient C57BL/6 genetic background.2011

    • Author(s)
      Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S
    • Journal Title

      Arthritis & Rheumatism

      Volume: 63 Issue: 10 Pages: 2930-2938

    • DOI

      10.1002/art.30485

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590194, KAKENHI-PROJECT-22659057, KAKENHI-PROJECT-23591450
  • [Journal Article] Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice: Implication of epistatic effects of Fcgr2b and Slam family genes.2011

    • Author(s)
      Fujii T, Hou R, Sato-Hayashibara A, Obata M, Ohtsuji M, Ikeda K, Mitsui K, Kodera Y, Shirai T, Hirose S, Nishimura H
    • Journal Title

      Eur. J. Immunol.

      Volume: 41 Pages: 2333-2340

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Journal Article] Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice : implication of epistatic effects of Fcgr2b and Slam family genes2011

    • Author(s)
      Fujii T, Hou R, Sato-Hayashizaki A, Obata M, Ohtsuji M, Ikeda K, Mitsui K, Kodera Y, Shirai T, Hirose S, Nishimura H
    • Journal Title

      Eur J Immunol

      Volume: 41 Issue: 8 Pages: 2333-40

    • DOI

      10.1002/eji.201141552

    • Data Source
      KAKENHI-PROJECT-23591450
  • [Journal Article] ポリエチレングリコール修飾抗原による免疫寛容の誘導2011

    • Author(s)
      尾畑賢臣 藤原 龍 西村裕之 小寺 洋
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56 Pages: 429-433

    • NAID

      40019053111

    • Data Source
      KAKENHI-PROJECT-23591450
  • [Journal Article] Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb-deficient C57BL/6 genetic background.2011

    • Author(s)
      Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S
    • Journal Title

      Arthritis Rheum

      Volume: 63 Pages: 2930-2938

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Journal Article] Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains : possible involvement in SLE pathogenesis2008

    • Author(s)
      Tsukamoto H, Ohtsuji M, Shiroiwa W, Lin Q, Nakamura K, Tsurui H, Jiang Y, Sudo K, Nishimura H, Shirai T, and Hirose S
    • Journal Title

      J. Immunol 180

      Pages: 4530-4539

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591181
  • [Journal Article] Poly(ethlene glycol)-modified Mn-SOD for prolonging its half-life in blood circulation2008

    • Author(s)
      Y Hada, M Takahashi, H Nishimura, Y Kodera, N Kawashima
    • Journal Title

      Material Technology 26

      Pages: 18-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17500319
  • [Journal Article] IL-4R・polymorphism in regulation of IL-4 synthesis by T cells : implication in susceptibility to a subset of murine lupus2007

    • Author(s)
      Shiroiwa W, Tsukamoto K, Ohtsuji M, Lin Q, Ida A, Kodera S, Ohtsuji N, Nakamura K, Tsurui H, Kinoshita K, Nishimura H, Shirai T, and Hirose S
    • Journal Title

      Int. Immunol 19

      Pages: 175-183

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591181
  • [Journal Article] CD3 and IgG Fc receptor regulate cerebellar functions2007

    • Author(s)
      Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xiu Y, Ohtsuji M, Qing Shun Lin Q, Tsukamoto K, Nishimura H, Ono M, Watanabe M and Hirose S
    • Journal Title

      Mol. Cell. Biol 27

      Pages: 5128-5134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591181
  • [Journal Article] Genetic control of the spontaneous activation of CD4^+ Th cells in systemic lupus erythematosus-prone(NZB x NZW) F_1 mice.2006

    • Author(s)
      T Fujii, K Ikeda, N Nishimura, J Tokei, K Mitsui, Y Kodera, Y Inada, Y Xiu, K Nakamura, T Shirai, S Hlrose, H Nishimura
    • Journal Title

      Genes and Immunity 7

      Pages: 647-654

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17500319
  • [Journal Article] SLE遺伝子2005

    • Author(s)
      西村裕之, 広瀬幸子
    • Journal Title

      「免疫2005」Molecular Medicine 臨時増刊号 41

      Pages: 334-334

    • Data Source
      KAKENHI-PROJECT-15590282
  • [Journal Article] A role for TARC/CCL1, a CC chemokine in New Zealand mice.2005

    • Author(s)
      Okamoto H, Nishimura H, Kamatani N.
    • Journal Title

      Rheumatology 44

      Pages: 819-828

    • Data Source
      KAKENHI-PROJECT-15590282
  • [Journal Article] Phenylalanine ammonia-lyase modified with polyethylene glycol : potential therapeutic agent for phenylketonuria.2005

    • Author(s)
      K Ikeda, E Schiltz, T Fujii, M Takahashi, K Mitsui, Y Kodera, A Matsushima, Y Inada, GE Schulz, H Nishimura
    • Journal Title

      Amino Acids 29

      Pages: 283-287

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17500319
  • [Journal Article] Correlation of aggression with serum IgM level in autoimmune-prone NZB mice.2005

    • Author(s)
      Nakamura K, Nishimura H, Hirose S et al.
    • Journal Title

      Dev. Brain Res. 159

      Pages: 145-148

    • Data Source
      KAKENHI-PROJECT-15590282
  • [Journal Article] SLE感受性遺伝子2005

    • Author(s)
      西村裕之 他
    • Journal Title

      免疫2005(Molecular medicine) 41 臨時増刊号

      Pages: 334-342

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590282
  • [Presentation] Epistatic interaction between Fcgr2b and Slam family genes in susceptibility to defective foreign protein-induced tolerance.2017

    • Author(s)
      Hiroyuki Nishimura, et al.
    • Organizer
      第46回 日本免疫学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Presentation] Mechanism for cell type-specific contribution of inhibitory IgG Fc receptor IIB in Yaa-induced murine lupus.2016

    • Author(s)
      Hirose S, Lin, Q, Amano H, Nishimura H, Verbeek JS
    • Organizer
      10th International Congress on Autoimmunity
    • Place of Presentation
      Leipzig, Germany
    • Year and Date
      2016-04-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Presentation] Inhibitory IgG Fc receptor IIB on B cells and monocytes independenly controls Yaa-induced murine lupus.2016

    • Author(s)
      Lin Q, Tsurui H, Nishikawa K, Amano H, Ohtsuji M, Nishimura H, Verbeek JS, Hirose S.
    • Organizer
      第45回 日本免疫学会総会・学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Presentation] Epistatic interaction between Fcgr2b and Slam family genes in susceptibility to defective foreign protein-induced tolerance.2016

    • Author(s)
      Nishimura H, Fujii T, Obata M, Ohtsuji M, Kodera Y, Takai T, Sudo K, Hirose S.
    • Organizer
      第45回 日本免疫学会総会・学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Presentation] Blocking of CD11b+ cell-migration ameliorates rheumatoid arthritis-like disease spontaneously occurring in a unique FcγRIIB-deficient mouse model.2016

    • Author(s)
      Ohtsuji M, Lin Q, Okazaki H, Ikeda S, Sasaki H, Amano H, Yagita H, Nishimura H, Hirose S.
    • Organizer
      第45回 日本免疫学会総会・学術集会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Presentation] Role of inhibitory FcγRIIb and autoimmune-prone SLAM haplotype in autoimmune disease.2015

    • Author(s)
      NISHIKAWA Keiko, LIN Qingshun, TSURUI Hiromichi, AMANO Hirofumi, OKAZAKI Hideki, OHTSUJI Mareki, NISHIMURA Hiroyuki, SHIRAI Toshikazu, HIROSE Sachiko.
    • Organizer
      第44回 日本免疫学会総会・学術集会
    • Place of Presentation
      札幌市、北海道
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Presentation] Cell type-specific inhibitory IgG Fc receptor IIB in Yaa-induced murine lupus.2015

    • Author(s)
      LIN Qingshun, TSURUI Hiromichi, NISHIKAWA Keiko, AMANO Hirofumi, OHTSUJI Mareki, NISHIMURA Hiroyuki, SHIRAI Toshikazu, VERBEEK J. Sjef, HIROSE Sachiko.
    • Organizer
      第44回 日本免疫学会総会・学術集会
    • Place of Presentation
      札幌市、北海道
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Presentation] 細胞特異的FcγRIIB発現欠損マウス系の樹立によるYaa誘導ループス腎炎発症機序の解明2015

    • Author(s)
      林 青順、西川桂子、大辻希樹、天野浩文、西村裕之、白井俊一、広瀬幸子
    • Organizer
      第59回 日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋市、愛知県
    • Year and Date
      2015-04-23
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Presentation] Mechanism for cell type-specific contribution of inhibitory IgG Fc receptor IIB in Yaa-induced murine lupus.2015

    • Author(s)
      Sachiko HIROSE, Qingshun LIN, Hiroyuki NISHIMURA, Toshikazu SHIRAI, J.Sjef.VERBEEK.
    • Organizer
      The 10th international Toin Medical Engineering Symposium.
    • Place of Presentation
      桐蔭横浜大学、横浜市、神奈川
    • Year and Date
      2015-11-14
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Presentation] 関節炎自然発症FcγRIIB欠損マウスにおける抗IL-6R抗体の予防および治療効果の解析2015

    • Author(s)
      大辻希樹、林 青順、西川桂子、岡崎英規、天野浩文、西村裕之、西本憲弘、白井俊一、広瀬幸子
    • Organizer
      第59回 日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋市、愛知県
    • Year and Date
      2015-04-23
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Presentation] SLE発症に対するFcγRIIB欠損、Slam多型およびYaa遺伝子の影響2015

    • Author(s)
      西川桂子、林 青順、天野浩文、西村裕之、白井俊一、広瀬幸子
    • Organizer
      第59回 日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋市、愛知県
    • Year and Date
      2015-04-23
    • Data Source
      KAKENHI-PROJECT-15K08432
  • [Presentation] Peripheral tolerance of antigen-specific Th cell induced with polyethylene glycol-conjugate of protein antigen.2013

    • Author(s)
      Obata M, Ohtsuji M, Shirai T, Hirose S, Nishimura H.
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Presentation] Mechanism of Th-cell tolerance induced with the tolerogenic protein antigen conjugated with polyethylene glycol2012

    • Author(s)
      Obata M, Kodera Y, Ohtsuji M, Shirai T, Hirose S, Nishimura H.
    • Organizer
      Toin International Symposium on Biomedical Engineering 2012,
    • Place of Presentation
      Toin University of Yokohama, Aoba-ku Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Presentation] A novel locus of B6 mice on chromosome 12 plays a role in common process shared by SLE, RA and Sjogren syndrome.2012

    • Author(s)
      Kaneko T, Amano H, Ohtsuji M, Nishikawa K, Shinya K, Ohtsuji M, Lin Q, Okazaki H, Tsurui H, Nishimura H, Shirai T, Takasaki Y, Hirose S.
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      神戸国際会議場、神戸
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Presentation] Mechanism of Th cell tolerance induced with tolerogenic polyethylene glycol(PEG)-conjugate of protein antigen2012

    • Author(s)
      Obata M, Ohtsuji M, Shirai T, Hirose S, Nishimura H.
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      神戸国際会議場、神戸
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Presentation] Phenotype conversion from RA to SLE in FcgRIIB-deficient B6 mice by Yaa mutation.2012

    • Author(s)
      Kawano S, Amano H, Lin Q, Kaneko T, Nishikawa K, Okazaki H, Tsurui H, Nishimura H, Shirai T, Takasaki Y, Hirose S
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      神戸国際会議場、神戸
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Presentation] The role of SLAM-signal in SLE.2012

    • Author(s)
      Lin Q, Tsurui H, Nishikawa K, Okazaki H, Ohtsuji M, Nishimura H, Ono M, Shirai T, Hirose S.
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      神戸国際会議場、神戸
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Presentation] Presumptive role of 129 strain-derived Sle16 locus for rheumatoid arthritis in a new mouse model with FcgRIIB-deficient C57BL/6 genetic background.2011

    • Author(s)
      Sato A, Ohtsuji M, Lin Q, Ohtsuji N, Nishikawa K, Tsurui H, Ono M, Shirai T, Takai T, Nishimura H, Hirose S.
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Presentation] ポリエチレングリコール修飾抗原によって誘導されるTh細胞免疫寛容の機序・Mechanism of Th-cell tolerance induced with tolerogenic protein antigen conjugated with polyethylene glycol.2011

    • Author(s)
      藤原龍、尾畑賢臣、藤井琢磨、大辻希樹、小寺洋、広瀬幸子、西村裕之
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Presentation] SLEにおけるSLAMシグナルの役割・The role of SLAM signal in SLE2011

    • Author(s)
      林青順、大辻希樹、佐藤綾、大辻奈穂美、西川桂子、鶴井博理、須藤カツ子、西村裕之、小野栄夫、白井俊一、広瀬幸子
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ、千葉市
    • Data Source
      KAKENHI-PROJECT-23591450
  • [Presentation] (NZW x BXSB) F1マウスにおけるFcgr2bプロモーター領域の多型性の影響2008

    • Author(s)
      Lin Q、Tsurui H, Ohtsuji M, Amano H、Nishimura H, Shirai T, Hirose S
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-19591181
  • [Presentation] FcgR-dependent expansion of Gr-1- monocyte subset in lupus prone mice2008

    • Author(s)
      Amano H, Amano E, Lin Q. Ando S, Nishimura H, Moromoto S, Hirose S, Takasaki Y
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-19591181
  • [Presentation] BXSBマウスの末梢血単球増加におけるFcγレセプターの役割2008

    • Author(s)
      天野浩文、天野恵理、安藤誠一郎、仲野総一郎、森本真司、戸叶嘉明、林青順、西村裕之、広瀬幸子、高崎芳成
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-19591181
  • [Presentation] Therapeutic effects of phenylalanine ammonia-lyase modified with polyethylene glycol on the mouse model of phenylketonuria.2007

    • Author(s)
      M Kodajima, K Ikeda, N Okada, A Kusano, K Mitsui, Y Kodera, A Matsushima, Y Inada, H Nishimura
    • Organizer
      Toin International Symposium on Biomedical Engineering
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17500319
  • [Presentation] 末梢性の免疫寛容誘導における抑制性Fc受容体FcgRIIBの役割2007

    • Author(s)
      軸丸由梨、藤井琢磨、池田賢一、大木麻紀子、吉澤侑也、小寺洋、広瀬幸子、白井俊一、西村裕之
    • Organizer
      第37回日本免疫学会・学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19591181
  • [Presentation] Protection from autoimmune disease by restoration of impaired FcgRIIB expression2007

    • Author(s)
      Lin Q, Ohtsuji M, Amano H, Amano E, Tsurui H, Nishimura H, Shirai T, Hirose S
    • Organizer
      第37回日本免疫学会・学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19591181
  • [Presentation] BXSBマウスの末梢血単核球増加におけるIgGFcレセプターの役割2007

    • Author(s)
      天野浩文、天野恵理、安藤誠一郎、仲野総一郎、森本真司、戸叶嘉明、林青順、西村裕之、広瀬幸子、高崎芳成
    • Organizer
      第37回日本免疫学会・学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19591181
  • [Presentation] Association of NKT cell function with systemic lupus erythematosus2007

    • Author(s)
      Hirose S, Tsukamoto K, Ohtsuj M, Lin Q, Tsurui H, Nishimura H, Shirai T
    • Organizer
      第37回日本免疫学会・学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19591181
  • [Presentation] Polyethylene glycol modified enzymes alter the original characteristics.2006

    • Author(s)
      Y Kodera, Y Hada, K Wakabayashi, H Nishimura, A Matsushima, A Inada, S Takahashi
    • Organizer
      Toin International Symposium on Biomedical Engineering
    • Place of Presentation
      Yokohama
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17500319
  • [Presentation] Anti-inflammatory activity of chemically modified superoxide dismutase in collagen-induced arthritis model mice.2005

    • Author(s)
      K Wakabayashi, Y Hada, A Ochiai, H Matsuno, M Takahashi, H Nishimura, Y Kodera
    • Organizer
      78th Nihon Seika Gakkai
    • Place of Presentation
      Kobe
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17500319
  • 1.  HIROSE Sachiko (00127127)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 40 results
  • 2.  KODERA Yoh (80205426)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 6 results
  • 3.  SHIRAI Toshikazu (30115860)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 4.  TSURUI Hiromichi (40217386)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 5.  HAMANO Yoshitomo (10281354)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  SHIRAI Toshikazu (06404024)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  HIROTO Misao (00110172)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  FUTAMI Ayako (30209142)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  INADA Yuuji (40016035)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  JIANG Yi (50276466)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  OZAKI Shoichi (00231233)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ISHIKAWA Sho (00276479)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SUZUKI Kazuo (20192130)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  OKADA Takashi (20185440)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  TANNO Masataka (50171913)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SATO Hidetoshi (30091573)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  AMANO Hirofumi (50318474)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 18.  大辻 希樹 (30398664)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 19.  関川 巌 (80179332)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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