HIROSE Sachiko 広瀬幸子

… Alternative Names

広瀬幸子ヒロセサチコ

廣瀬幸子ヒロセサチコ

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Researcher Number	00127127
Other IDs
Affiliation (Current)	2025: 桐蔭横浜大学, 医用工学部, 客員研究員
Affiliation (based on the past Project Information) *help	2016 – 2017: 桐蔭横浜大学, 医用工学部, 客員研究員 2016: 桐蔭横浜大学, 工学部, 客員研究員 2015: 桐蔭横浜大学, 医用工学部, その他 2012 – 2015: 順天堂大学, 医学部, 准教授 2007 – 2008: Juntendo University, 医学部, 准教授 … More 1991 – 2006: 順天堂大学, 医学部, 助教授 1989: Juntendo University, Pathology, Associate Professor, 医学部, 助教授 1988: 順天堂大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Immunology / Experimental pathology / Laboratory animal science / Laboratory animal science / 膠原病・アレルギー・感染症内科学 / Biological Sciences Except Principal Investigator Biological Sciences / Collagenous pathology/Allergology / Experimental pathology / 内科学一般 / Pathological medical chemistry / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 全身性エリテマトーデス / 連鎖解析 / New Zealandマウス / FcγRIIB / 感受性遺伝子 / 遺伝子多型 / MHC class II / New Zealand mice / somatic mutation / 抗DNA抗体 … More / ループス腎炎 / PI3 kinase / 自己抗体 / B1細胞 / Th1 / G-CSF / Systemic lupus erythematosus / SNP / Ltk / H-2 recombination / コンジェニックマウス / 体細胞突然変異 / 抗体可変領域遺伝子 / systemic lupus erythematosus / 全身性エリテマト-デス / CD5B細胞 / 抗体遺伝子可変領域 / SLE / gain-of-function型多型 / 主要組織適合遺伝子複合体 / New Zealand マウス / QTL解析 / FcγRIIB1 / マイクロサテライト / 素因遺伝子 / 高IgG血症 / クローン性増殖 / マイクロサテライト法 / 自己免疫疾患 / 胚中心 / 抑制性igG Fc受容体 / Yaa変異遺伝子 / リンパ濾胞胚中心 / 抑制性IgG Fc受容体 / 自己抗体産生B細胞 / RNA sequencing / 単球 / 細胞特異的遺伝子欠損 / Yaa / Class II molecule / Congenic New Zealand mice / Anti-DNA antibody / T cell receptor / Major histocompatibility complex / ニュージーランドマウス / クラスII分子 / コンジェニックニュ-ジ-ランドマウス / T細胞抗原受容体 / 主要組織遺伝子複合体 / ニュ-ジ-ランドマウス / Th2 balance / (NZB x NZW) F1 mouse / susceptibility gene / linkage analysis / lupus nephritis / gene polymorphism / G-CSF receptor / 自己抗体産生 / IL-4 / 連鎖解 / Th2バランス / (NZB x NZW)F1マウス / G-CSFレセプター / Susceptible gene / Linkage study / B1 cell / Gain-of-function polymorphism / suppressor T cells / H-2-congenic mouse / I-E molecule / I-A molecule / ヘテロ接合性 / H-2-congeuicマウス / 抑制性T細胞 / H-2-congenicマウス / H-2recombination / I-E分子 / I-A分子 / MHC classII / CAT gene / affinity selection / Ig variable region gene / autoantibody / IgG anti-DNA antibody / Natural antibody / CAT遺伝子 / 親和性成熟 / 抵抗可変領域遺伝子 / 自然抗体 / IgG抗DNA抗体 / Congenic mouse / Autoimmune disease / Microsatellite / TNF gene polymorphism / MHCクラスII分子 / MHC class II分子 / TNF遺伝子多型 / レトロウイルス / 抗ヒストン抗体 / 抗gp70抗体 / clonal proliferation / class-switch / immunoglobulin variable region / anti-DNA antibodies / ハイブリド-マ / 免疫グロブリン遺伝子 / クラス転換 / サイトカイン / 疾患感受性遺伝子 / 疾患感受性 / 関節リウマチ / 疾患モデル / Akt / 樹状細胞 / Flt3 / Fc・RIIB / 樹上細胞 / 転写制御 / プロモーター領域多型 / 制御領域多型 / 自己感応性B細胞 / FCγRIIB / LTK / recombinant congenic マウス / IL-4Rα / MAPMAKER / 遺伝的要因 / 自然免疫 / アポトーシス / Fas / TNF receptor family / B細胞性慢性リンパ性白血病 … More Except Principal Investigator SLE / 自己免疫疾患 / 全身性エリテマトーデス / 疾患感受性遺伝子 / B1細胞 / New Zealandマウス / 自己免疫 / 多段階発癌 / B細胞性慢性リンパ性白血病(BCLL) / Yaa遺伝子 / モデルマウス / 関節リウマチ / Fcレセプター / 遺伝子 / 疾患モデルマウス / Fc receptor / Foxp3 / 疾患感受性 / disease susceptibility gene / autoimmune disease / 抗リン脂質抗体症候群 / NZB mice / 免疫寛容 / 遺伝連鎖解析 / 全身性自己免疫疾患 / マイクロアレイ / loss of heterozygosity(LOH) / prolactin / 位置的候補遺伝子 / B細胞性慢性リンパ性白血病 / Slam遺伝子 / Yaa / Slam / FcγRIIB / genetic linkage study / systemic lupus erythematosus / immune tolerance / NZW系マウス / New Zealand系マウス / ゲノムマッピング / 連鎖解析 / ポリエチレングリコール / 免疫グロブリン / 6系マウス / C57BL / 遺伝支配 / Fc受容体 / NZB系マウス / Immunological self-tolerance / Genetic susceptibilit / Co-stimulatory molecule / Semaphoring / Dendritic cells / Regulatory T cell / Autoimmune disease / CTLA-4 / GITR / 免疫学 / 病理学 / 単クローン抗体 / CD25 / helios / Gpr83 / GITR-L / 移植免疫 / 腫瘍免疫 / 樹状細胞 / 遺伝的疾患感受性 / セマフォリン / 教刺激分子 / 免疫自己寛容 / 制御性T細胞 / 自己免疫病 / Susceptibility genes / Multigeneic disease / Microsatellite / Genome screening / Genome / Genetics / Autoimmunity / 組織プラスミノーゲンアクチベーター遺伝子 / 遺伝子統御領域多型 / IgFc受容体IIB遺伝子 / 高IgG血症 / 高IgG抗体応答 / IgG遺伝子制御領域多型 / Fe受容体IIB遺伝子 / B細胞活性化 / 素因 / 多因子病 / 多遺伝子病 / ゲノム解析 / New Zealand mice / mutigenic disease / modifier gene / microsatellite markers / gene interaction / 自己免疫性血小板減少症 / トランスジェニックマウス / SLE素因遺伝子 / SLE(全身性エリテマトーデス) / ループス腎炎 / Mott cell / マイクロサテライトDNA解析 / 血小板減少症 / 抗血小板抗体 / 抗カルヂオリピン抗体 / 自己抗体 / 遺伝子統御 / MHCハプロタイプ / B-CLL / 多遺伝子疾患 / 修飾遺伝子 / マイクロサテライト解析 / 遺伝子間相互作用 / 自己免役疾患 / NZW mice / MHC class II / FcgRIIB / Fcgr2b / 多因子疾患 / QTL解析 / マイクロアレト / New Zealand White マウス / 量的形質遺伝子座(QTL) / H-2 / マイクロサテライトDNA / B-1細胞 / New Zealand Whiteマウス Less

Role of FcgRIIB for autoantibody production inside and outside of germinal centersPrincipal Investigator
- Principal Investigator
  
  Hirose Sachiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Toin University of Yokohama
Effect of SLAM mutation and activating and inhibitory FcR on autoimmune prone mice
- Principal Investigator
  
  TAKASAKI Yoshinari
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Juntendo University
Genotype identification of RA and SLE using Fc gamma RIIB-deficient B6 mice.
- Principal Investigator
  
  Amano Hirofumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Juntendo University
Epistatic interaction of FcgammaRIIB and Sle16 polymorphism in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  HIROSE Sachiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University
Pathogenesis of SLE: Linkage Analysis of Critical Signaling Pathways
- Principal Investigator
  
  NISHIMURA Hiroyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Toin University of Yokohama
A novel regulatory role of IgG Fc receptor IIB in Flt3L-mediated dendritic cell developmentPrincipal Investigator
- Principal Investigator
  
  HIROSE Sachiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Juntendo University
Role of G-CSF and C-CSF receptor gene polymorphisms for the development of lupus nephritisPrincipal Investigator
- Principal Investigator
  
  HIROSE Sachiko, 姜奕
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  JUNTENDO UNIVERSITY
Genetic control of the defective immune tolerance in systemic lupus erythematosus-prone New Zealand Black mice.
- Principal Investigator
  
  NISHIMURA Hiroyuki
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  TOIN HUMAN SCIENCE AND TECHNOLOGY CENTER, TOIN UNIVERSITY OF YOKOHAMA
Ltk gene polymorphism and aberrant activation of autoreactive B cellsPrincipal Investigator
- Principal Investigator
  
  HIROSE Sachiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  JUNTENDO UNIVERSITY
自己反応性B細胞の寛容破綻に関わる遺伝的機構とその制御Principal Investigator
- Principal Investigator
  
  広瀬幸子
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
遺伝性がんB細胞性慢性リンパ性白血病の多段階発がん・転移進展機構の解析
- Principal Investigator
  
  濱野慶朋
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
Immune tolerance and regulation towards understanding and cure of autoimmune disease
- Principal Investigator
  
  SAKAGUCHI Shimon
- Project Period (FY)
  2001 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
遺伝性がんB細胞性慢性リンパ性白血病の感受性遺伝子と多段階発がん機構の解析
- Principal Investigator
  
  濱野慶朋
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
B細胞性慢性リンパ性白血病におけるB1細胞腫瘍化の分子機構の解析
- Principal Investigator
  
  濱野慶朋
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内科学一般
- Research Institution
  Juntendo University
Mechanism for MHC class II E region-linked autoimmune suppression.Principal Investigator
- Principal Investigator
  
  HIROSE Sachiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  JUNTENDO UNIVERSITY
自然発症モデルマウス系によるB細胞性慢性リンパ性白血病の疾患感受性遺伝子群の解析
- Principal Investigator
  
  濱野慶朋
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Juntendo University
自己反応性B1細胞の異常増殖分化に基ずく疾患とその修復Principal Investigator
- Principal Investigator
  
  広瀬幸子
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Juntendo University
Genetic factors Involved in the Pathogenesis of Autoimmune Disea
- Principal Investigator
  
  SHIRAI Toshikazu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Experimental pathology
- Research Institution
  JUNTENDO UNIVERSITY
自己反応性B1細胞の異常増殖分化に基ずく疾患とその修復Principal Investigator
- Principal Investigator
  
  広瀬幸子
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Juntendo University
新しいB細胞性慢性リンパ性白血病の責任遺伝子の同定
- Principal Investigator
  
  HAMANO Yoshitomo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  内科学一般
- Research Institution
  Juntendo University
Studies on mechanism of pathogenic autoantibody production using CAT-transgenic autoimmune-prone micePrincipal Investigator
- Principal Investigator
  
  HIROSE Sachiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Juntendo University
自己抗体産生B1細胞の増殖、分化、親和性成熟の分子機構Principal Investigator
- Principal Investigator
  
  広瀬幸子
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Juntendo University
遺伝性腫瘍としてのB細胞性慢性リンパ性白血病の疾患素因遺伝子の解析Principal Investigator
- Principal Investigator
  
  広瀬幸子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Juntendo University
Effect of TNF gene polymorphism on autoimmune diseasePrincipal Investigator
- Principal Investigator
  
  HIROSE Sachiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University School of Medicine
Genetic polymorphism of SLE
- Principal Investigator
  
  SHIRAI Toshikazu
- Project Period (FY)
  1994 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo Univeristy
レトロウイルス感染と自己免疫疾患の相関に関する分子免疫学的研究Principal Investigator
- Principal Investigator
  
  広瀬幸子
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University
Origin of class-specific anti-DNA antibodiesPrincipal Investigator
- Principal Investigator
  
  HIROSE Sachiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University School of Medicine
Role of class II molecule and T cell receptor in autoantibody production.Principal Investigator
- Principal Investigator
  
  HIROSE Sachiko
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University

[Book] 全身性エリテマトーデスにおける動物モデルの作製と解析手法 in 動物/疾患モデルの作製技術・病態解析・評価手法2017
- Author(s)
  広瀬幸子
- Total Pages
  428
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-15K08432
[Book] Arthritis Research, Methods and Protocols, Second Edition.2014
- Author(s)
  Masaomi Obata, Mareki Ohtsuji, Yukiyasu Iida, Toshikazu Shirai, Sachiko Hirose, and Hiroyuki Nishimura
- Total Pages
  204
- Publisher
  Human Press
- Data Source
  KAKENHI-PROJECT-24590491
[Journal Article] A restricted role for FcγR in the regulation of adaptive immunity.2018
- Author(s)
  ②Fransen MF, Benonisson H, van Maren WW, Sow HS, Breukel C, Linssen MM, Claassens JWC, Brouwers C, van der Kaa J, Camps M, Kleinovink JW, Vonk KK, van Heiningen S, Klar N, van Beek L, Van Harmelen V, Daxinger L, Nandakumar KS, Holmdar R, Coward C, Lin Q, Hirose S, et al.
- Journal Title
  
  J. Immunol.
  
  Volume: 200 Issue: 8 Pages: 2615-2626
- DOI
  10.4049/jimmunol.1700429
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08432
[Journal Article] A novel pathway of peripheral B cell tolerance breakdown induced by inhibitory IgG Fc receptor IIb-deficient monocytes.2018
- Author(s)
  Lin Q, Ohtsuji M, Amano H, Tsurui H, Tada N, Sato R, Fukuyama H, Nishimura H, Verbeek JS, and Hirose S.
- Journal Title
  
  J. Immunol.
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08432
[Journal Article] Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice.2018
- Author(s)
  Ohtsuji M, Lin Q, Okazaki H, Takahashi K, Amano H, Yagita H, Nishimura H, and Hirose S.
- Journal Title
  
  Arthritis Res. Ther.
  
  Volume: 20:25 Issue: 1 Pages: 1-11
- DOI
  10.1186/s13075-018-1523-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08432, KAKENHI-PROJECT-16K09907
[Journal Article] SLEの発症機序2016
- Author(s)
  広瀬幸子
- Journal Title
  
  最新医学　診断と治療のABC 118
  
  Volume: ー Pages: 44-52
- Data Source
  KAKENHI-PROJECT-15K08432
[Journal Article] IL-6 signal blockade ameliorates the enhanced osteoclastogenesis and the associated joint destruction in a novel FcγRIIB-deficient rheumatoid arthritis mouse model.2015
- Author(s)
  Ohtsuji M, Lin Q, Nishikawa K, Ohtsuji N, Okazaki H, Tsurui H, Amano H, Shirai T, Nishimoto N, Nishimura H, and Hirose S.
- Journal Title
  
  Mod. Rheumatol.
  
  Volume: 25 Issue: 2 Pages: 270-277
- DOI
  10.3109/14397595.2014.950035
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-25330349, KAKENHI-PROJECT-15K08432
[Journal Article] Genome-wide genetic study in autoimmune disease-prone mice.2014
- Author(s)
  Obata M, Ohtsuji M, Iida Y, Shirai T, Hirose S, Nishimura H
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1142 Pages: 111-41
- DOI
  10.1007/978-1-4939-0404-4_13
- ISBN
  9781493904037, 9781493904044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591450
[Journal Article] Dichotomy in the FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and glomerulonephritis.2014
- Author(s)
  Kanari Y, Sugahara–Tobinai A, Takahashi H, Inui M, Nakamura A, Hirose S, Takai T.
- Journal Title
  
  BMC Immunol
  
  Volume: 15 Issue: 1 Pages: 47-47
- DOI
  10.1186/s12865-014-0047-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-24590572, KAKENHI-PROJECT-25460601
[Journal Article] TNFα but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcγRIIB-deficient mouse model.2014
- Author(s)
  Okazaki H, Lin Q, Nishikawa K, Ohtsuji N, Tsurui H, Ohtsuji M, Amano H, Tada N, Sudo K, Nishimura H, Shirai T, and Hirose S.
- Journal Title
  
  Mod. Rheumatol.
  
  Volume: 24 Issue: 6 Pages: 931-938
- DOI
  10.3109/14397595.2014.886351
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-25330349
[Journal Article] TNFalpha but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcgammaRIIB-deficient mouse model.2014
- Author(s)
  Okazaki H, Lin Q, Nishikawa K, Ohtsuji N, Tsurui H, Ohtsuji M, Amano H, Tada N, Sudo K, Nishimura H, Shirai T, Hirose S
- Journal Title
  
  Mol Rheumatol
  
  Volume: Mar 4 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591450
[Journal Article] CD72c is a modifier gene that regulates Faslpr-induced autoimmune disease.2013
- Author(s)
  Xu, M., Hou, R., Sato-Hayashizaki, A., Man, R., Zhu, C., Wakabayashi, C, Hirose, S., Adachi, T. and Tsubata, T.
- Journal Title
  
  J. Immunol.
  
  Volume: 190 Issue: 11 Pages: 5436-5445
- DOI
  10.4049/jimmunol.1203576
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390063, KAKENHI-PROJECT-24590491
[Journal Article] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcgRIIB-deficient C57BL/62013
- Author(s)
  Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H,Takai T, Shirai T, Takasaki Y and Hirose S
- Journal Title
  
  mice.
  
  Volume: 43 Issue: 3 Pages: 770-778
- DOI
  10.1002/eji.201243057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590194, KAKENHI-PROJECT-23591450, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-24659215, KAKENHI-PROJECT-25330349, KAKENHI-PROJECT-25461486
[Journal Article] Nephrotoxic effect of subchronic exposure to <i>S</i>-(1,2-dichlorovinyl)-<i>L</i>-cysteine in mice2012
- Author(s)
  Shirai N, Ohtsuji M, Hagiwara K, Tomisawa H, Ohtsuji N, Hirose S, Hagiwara H.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 37 Issue: 5 Pages: 871-878
- DOI
  10.2131/jts.37.871
- NAID
  130004447001
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590491
[Journal Article] Development of a model of early-onset IgA nephropathy.2012
- Author(s)
  Okazaki K, Suzuki Y, Otsuji M, Suzuki H, Kihara M, Kajiyama T, Hashimoto A, Nishimura H, Brown R, Hall S, Novak J, Izui S, Hirose S, Tomino Y.
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 23 Issue: 8 Pages: 2930-2938
- DOI
  10.1681/asn.2011121160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591450, KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-24591213
[Journal Article] Transgenic overexpression of G5PR that is normally augmented in centrocytes impairsthe enrichment of high-affinity antigen-specific B cells, increases peritoneal B-1a cells, and induces autoimmunity in aged female mice2012
- Author(s)
  hi H, Ohtsuji M, Tsurui H, Hirose S, and Sakaguchi N
- Journal Title
  
  J. Immunol
  
  Volume: 189 Issue: 3 Pages: 1193-1201
- DOI
  10.4049/jimmunol.1102774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590194, KAKENHI-PROJECT-23390122, KAKENHI-PROJECT-23791116, KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-24659224
[Journal Article] Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb-deficient C57BL/6 genetic background.2011
- Author(s)
  Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S
- Journal Title
  
  Arthritis Rheum
  
  Volume: 63 Pages: 2930-2938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591450
[Journal Article] Presumptive role of 129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcy receptor type Iib-deficient C57BL/6 genetic background.2011
- Author(s)
  Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S
- Journal Title
  
  Arthritis & Rheumatism
  
  Volume: 63 Issue: 10 Pages: 2930-2938
- DOI
  10.1002/art.30485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590194, KAKENHI-PROJECT-22659057, KAKENHI-PROJECT-23591450
[Journal Article] Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice : implication of epistatic effects of Fcgr2b and Slam family genes2011
- Author(s)
  Fujii T, Hou R, Sato-Hayashizaki A, Obata M, Ohtsuji M, Ikeda K, Mitsui K, Kodera Y, Shirai T, Hirose S, Nishimura H
- Journal Title
  
  Eur J Immunol
  
  Volume: 41 Issue: 8 Pages: 2333-40
- DOI
  10.1002/eji.201141552
- Data Source
  KAKENHI-PROJECT-23591450
[Journal Article] Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice: Implication of epistatic effects of Fcgr2b and Slam family genes.2011
- Author(s)
  Fujii T, Hou R, Sato-Hayashibara A, Obata M, Ohtsuji M, Ikeda K, Mitsui K, Kodera Y, Shirai T, Hirose S, Nishimura H
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 41 Pages: 2333-2340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591450
[Journal Article] Fc・R-dependent expansion of a hyperactive monocyte subset in lupus-prone mice2009
- Author(s)
  Santiago-Raber M-L, Amano H, Amano E, Baudino L, Otani M, Lin Q, Nimmerjahn F, Sjef Verbeek J, Ravetch JV, Takasaki Y, Hirose S, and Izui S
- Journal Title
  
  Arthritis Rheum (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] 自己免疫の発症とFcgレセプター臨床免疫・アレルギー科2009
- Author(s)
  広瀬幸子、林青順
- Journal Title
  
  科学評論社 (印刷中)
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD. CD72^b congenic mice2009
- Author(s)
  Hou R, Ohtsuji M, Ohtsuji N , Zhang L, Adachi T, Hirose S, Tsubata. T
- Journal Title
  
  Biochem. Biophys. Res. Commun 380
  
  Pages: 193-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] Ankylosing enthesitis associated with up-regulated IFN- and IL-17 production in (BXSB x NZB) F1 male mice ; a new mouse model2009
- Author(s)
  Abe Y, Ohtsuji M, Ohtsuji N, Lin Q, Tsurui H, Nakae S, Shirai T, Sudo K, and Hirose S
- Journal Title
  
  Mod. Rheum (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] Splenic phagocytes promotes to nucleosomes in (NZB x NZW) F1 mice2008
- Author(s)
  Okamoto A, Fujio K, van Rooijen N, Tsuno NH, Takahashi T, Tsurui H, Hirose S, Elkon KB, and Yamamoto K
- Journal Title
  
  J. Immunol 181
  
  Pages: 5264-5271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] Jorgensen, TN, Tucker RM, Roark CL, Kotzin BL, Evans LH, and Izui S. Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis2008
- Author(s)
  Baudino L, Yoshinobu K, Morito N, Kikuchi S, Fossati-Jimack L, Morley BJ, Vyse TJ, Hirose S
- Journal Title
  
  J. Immunol 181
  
  Pages: 2846-2854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains : possible involvement in SLE pathogenesis2008
- Author(s)
  Tsukamoto H, Ohtsuji M, Shiroiwa W, Lin Q, Nakamura K, Tsurui H, Jiang Y, Sudo K, Nishimura H, Shirai T, and Hirose S
- Journal Title
  
  J. Immunol 180
  
  Pages: 4530-4539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice2008
- Author(s)
  Moriyama Y, Sekine C, Koyanagi A, Koyama N, Ogata H, Chiba S, Hirose S, Okumura K, and Yagita H
- Journal Title
  
  Int. Immunol 20
  
  Pages: 763-773
- NAID
  10021241547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] IL-4R・polymorphism in regulation of IL-4 synthesis by T cells : implication in susceptibility to a subset of murine lupus2007
- Author(s)
  Shiroiwa W, Tsukamoto K, Ohtsuji M, Lin Q, Ida A, Kodera S, Ohtsuji N, Nakamura K, Tsurui H, Kinoshita K, Nishimura H, Shirai T, and Hirose S
- Journal Title
  
  Int. Immunol 19
  
  Pages: 175-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] 全身性自己免疫疾患とFc・レセプターによる免疫反応の正と負の調節2007
- Author(s)
  林青順、広瀬幸子
- Journal Title
  
  臨床免疫・アレルギー科科学評論社 47
  
  Pages: 545-550
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] CD3 and IgG Fc receptor regulate cerebellar functions2007
- Author(s)
  Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xiu Y, Ohtsuji M, Qing Shun Lin Q, Tsukamoto K, Nishimura H, Ono M, Watanabe M and Hirose S
- Journal Title
  
  Mol. Cell. Biol 27
  
  Pages: 5128-5134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] 全身性自己免疫疾患とFcγレセプターによる免疫反応の正と負の調節2007
- Author(s)
  林青順、広瀬幸子
- Journal Title
  
  臨床免疫・アレルギー科 47
  
  Pages: 545-550
- Data Source
  KAKENHI-PROJECT-19591181
[Journal Article] CD3 and IgG Fc receptor regulate cerebellar functions.2007
- Author(s)
  Nakamura K, Hirai H, Torashima T, Miyazaki T, Tsurui H, Xiu Y, Ohtsuji M, Qing Shun Lin Q, Tsukamoto K, Nishimura H, Ono M, Watanabe M, Hirose S.
- Journal Title
  
  Mol. Cell. Biol.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Significance of MHC class II haplotypesand IgG Fc receptors in SLE.2006
- Author(s)
  Hirose S, Jiang Y, Nishimura H, Shirai T.
- Journal Title
  
  Springer Seminars in Immnopathol. 28
  
  Pages: 163-174
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Molecular pathogenesis of SLE.2006
- Author(s)
  Shirai T, Hirose S.
- Journal Title
  
  Springer Seminars in Immunopathology 28
  
  Pages: 79-82
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] IL-4Rα polymorphism in regulation of IL-4 synthesis by T cells : implication in susceptibility to a subset of murine lupus.2006
- Author(s)
  Shiroiwa W, Tsukamoto K, Ohtsuji M, Lin Q, Ida A, Kodera S, Ohtsuji M, Nishimura H, Tsurui H, Kinoshita K, Nishimura H, Shirai T, Hirose S.
- Journal Title
  
  Int.. Immunol. 19
  
  Pages: 175-183
- NAID
  10020111784
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Genetic control of the spontaneous activation of CD4+ Th cells in systemic lupus erythematosus-prone (NZB x NZW) Fl mice..2006
- Author(s)
  Fujii T, Iida Y, Yomogida M, Ikeda K, Haga T, Jikumaru Y, Ninami M, Nishimura N, Kodera Y, Inada Y, Shirai T, Hirose S, Nishimura H.
- Journal Title
  
  Genes Immun. 7
  
  Pages: 647-654
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus..2006
- Author(s)
  Lin Q, Xiu Y, Jiang Y, Tsurui H, Nakamura K, Kodera S, Ohtsuji M, Ohtsuji N, Shiroiwa W, Tsukamoto K, Amano H, Amano E, Kinoshita K, Sudo K, Nishimura H, Izui S, Shirai T, Hirose S.
- Journal Title
  
  J. Immunol. 177
  
  Pages: 1646-1654
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Genetic dissection of vasculitis, myeloperoxidase- specific antineutrophil cytoplasmic autoantibody production, and renl traits in spontaneous crescentic glomerulonephritis-forming/Kinjo mice.2006
- Author(s)
  Hamano Y, Tsukamoto K, Abe M, Sun G, D, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Ogawara A, Tachikawa H, Nishimura H, Tokunaga K, Hirose S, Suzuki K
- Journal Title
  
  J. Immunol. 176
  
  Pages: 3662-3673
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Significance of MHC class II haplotypesand IgG Fe receptors in SLE.2006
- Author(s)
  Hirose S., et al.
- Journal Title
  
  Springer Seminars in Immnopathol. 28
  
  Pages: 163-174
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Correlation of aggression with serum IgM level in autoimmune-prone NZB mice..2005
- Author(s)
  Nakamura K, Nishimura H, Hirose S
- Journal Title
  
  Dev. Brain Res. 159
  
  Pages: 145-148
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] SLE遺伝子2005
- Author(s)
  西村裕之, 広瀬幸子
- Journal Title
  
  「免疫2005」Molecular Medicine 臨時増刊号 41
  
  Pages: 334-334
- Data Source
  KAKENHI-PROJECT-15590282
[Journal Article] Correlation of aggression with serum IgM level in autoimmune-prone NZB mice.2005
- Author(s)
  Nakamura K, Nishimura H, Hirose S et al.
- Journal Title
  
  Dev. Brain Res. 159
  
  Pages: 145-148
- Data Source
  KAKENHI-PROJECT-15590282
[Journal Article] Fas ligand and TNF-related apoptosis-inducing ligand induction on infiltrating lymphocytes in bladder carcinoma by bacillus Calmette-Guerin treatment.2005
- Author(s)
  Mehmut M, Takeda K, Abe M., Ogara H, Hirose S, Okumura K, Fujime M
- Journal Title
  
  Urol. Int. 75
  
  Pages: 80-87
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Chromosomal mapping of a quantitative trait locus for the development of albunuria in diabetic KK/Ta mice.2005
- Author(s)
  Shike T, Gohda T, Tanimoto M, Kobayashi M, Makita Y, Funabiki K, Horikoshi, Hirose S, Shirai T, Tomino Y
- Journal Title
  
  Nephrol Dial. Transplant. 20
  
  Pages: 879-885
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Polymorphism of the mouse gene for the interleukin 10 receptor alpha chain (Il10ra) and its association with the autoimmune phenotype..2005
- Author(s)
  QI Z, Wang J, Sun Z, Ma F, Zhang Q, Hirose S, Jiang Y
- Journal Title
  
  Immunogenetics 57
  
  Pages: 697-702
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease, but increases the risk of B-cell chronic lymphocytic leukemia in a model of murine lupus.2004
- Author(s)
  Wen X, Zhang D, Kikuchi Y, Jiang Y, Nakamura K, Xiu Y, Tsurui H, Takahashi K, Abe M, Ohtsuji M, Nishimura H, Takatsu K, Shirai T, Hirose S.
- Journal Title
  
  Eur.J.Immunol. 34
  
  Pages: 2740-2749
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300145
[Journal Article] Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease.2004
- Author(s)
  Fujio K, Okamoto A, Tahara H, Abe M, Jiang Y, Kitamura T, Hirose S, Yamamoto K
- Journal Title
  
  J. Immunol. 173
  
  Pages: 2118-2125
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Dissection of the role of MHG class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination.2004
- Author(s)
  Zhang D, Fujio K, Jiang Y, Zhao J, Tada N, Sudo K, Tsurui H, Nakamura K, Yamamoto K, Nishimura H, Shirai T, Hirose S
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 101
  
  Pages: 13838-13843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Gain-of-function polymorphism in mouse and human Ltk : implications for the pathogenesis of systemic lupus erythematosus.2004
- Author(s)
  Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S.
- Journal Title
  
  Hum.Mol.Genet. 13
  
  Pages: 171-179
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300145
[Journal Article] Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination.2004
- Author(s)
  Zhang D, Fujio K, Jiang Y, Zhao J, Tada N, Sudo K, Tsurui H, Nakamura K, Yamamoto K, Nishimura H, Shirai T, Hirose S.
- Journal Title
  
  Proc.Nati.Acad.Sci.USA 101
  
  Pages: 13838-13843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300145
[Journal Article] Measurement of mouse urinary typelV collagen using time-resolved fluoroimmunoassay.2003
- Author(s)
  Kobayashi M, Kimura H, Liao J, Abe M, Hirose S, Tomino Y.
- Journal Title
  
  Anal. Science 19
  
  Pages: 205-210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Spontaneous increase of plasma-like cells with high GAMP expression in the extrafollicular region of lymphoid organs of autoimmune-prone mice.2003
- Author(s)
  Fujimura S, Kuwahara K, Ezaki T, Tomita K, Hirose S, Sakaguchi N.
- Journal Title
  
  J.Autoimmunity 20
  
  Pages: 291-301
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300145
[Journal Article] Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.2003
- Author(s)
  Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Miyasaka N, Azuma M.
- Journal Title
  
  J.Immunol. 171
  
  Pages: 2848-2854
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300145
[Journal Article] Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses.2003
- Author(s)
  Tsushima F, Iwai H, Otsuki N, Abe M, Hirose S, Yamazaki T, Akiba H, Yagita H, Takahashi Y, Omura K, Okumura K, Azuma M.
- Journal Title
  
  Eur. J. Immunol 33
  
  Pages: 2773-2782
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] A monoclonal antibody to the a2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model.2003
- Author(s)
  Matsuoka S, Tsurui H, Abe M, Terashima K, Nakamura K, Hamano Y, Ohtsuji M, Honma N, Serizawa I, Ishii Y, Takiguchi M, Hirose S, Shirai T.
- Journal Title
  
  J.Exp.Med. 198
  
  Pages: 497-503
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15300145
[Journal Article] A monoclonal antibody to the a2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model.2003
- Author(s)
  Matsuoka S, Tsurui H, Abe M, Terashima K, Nakamura K, Hamano Y, Ohtsuji M, Honma N, Serizawa I, Ishii Y, Takiguchi M. Hirose S, Shirai T.
- Journal Title
  
  J. Exp. Med. 198
  
  Pages: 497-503
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.2003
- Author(s)
  Iwai H, Abe S., Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M.
- Journal Title
  
  J. Immunol 171
  
  Pages: 2848-2854
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Spontaneous increase of plasma-like cells with high GAMP expression in the extrafollicular region of lymphoid organs of autoimmune-prone mice.2003
- Author(s)
  Fujimura S, Kuwahara K, Ezaki T, Tomita K, Hirose S, Sakaguchi N.
- Journal Title
  
  J. Autoimmunity 20
  
  Pages: 291-301
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.2003
- Author(s)
  Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Miyasaka N, Azuma M.
- Journal Title
  
  J. Immunol. 171
  
  Pages: 2848-2854
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ.2002
- Author(s)
  Miyamoto A, Nakayama K, Hirose S, Jiang Y, Abe M, Tsukiyama T, Nagahama H. Ohno S. Hatakeyama S, Nakayama K
- Journal Title
  
  Nature 416
  
  Pages: 865-869
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Clq regulatory region polymorphism down-regulating murine Clq protein levels with linkage to lupus nephritis.2002
- Author(s)
  Miura-Shimura Y, Nakamura K, Ohtsuji M, Tomita H, Jiang Y, Abe M, Zhang D, Hamano Y, Tsuda H, Hashimoto H, Nishimura H, Taki S, Shirai T, Hirose S
- Journal Title
  
  J. Immunol. 169
  
  Pages: 1334-1339
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Genetic basis of systemic lupus erythematosus.2002
- Author(s)
  Hirose S, Jiang Y, Hamano Y, Nishimura H
- Journal Title
  
  Drugs of Today 38
  
  Pages: 167-184
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Suppression of antibody production by TNF-related apoptosis-inducing ligand (TRAIL).2002
- Author(s)
  Kayagaki N, Yamaguchi N, Abe M, Hirose S, Shirai T, Okumura K, Yagita H.
- Journal Title
  
  Cellular Immunol. 219
  
  Pages: 82-91
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune response2002
- Author(s)
  Xiu Y, Nakamura K, Abe M, Li N, Wen X-S, Jiang Y, Zhang D, Tsurui.H, Matsuoka S, Hamano Y, Fujii H, Ono M, Takai T, Shimokawa T, Ra C, Shirai T, Hirose S
- Journal Title
  
  J. Immuno.l. 169
  
  Pages: 4340-4346
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Genetic basis of systemin lupus erythematosus.2002
- Author(s)
  Hirose S., et al.
- Journal Title
  
  Drugs of Today 38
  
  Pages: 167-184
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Amelioration of collagen-induced arthritis by brokade of inducible costimulator-b7 homologous protein costimulation.2002
- Author(s)
  Iwai H, Kozono Y, Hirose S, Akiba H, Yagita H, Okumuea K, Kohsaka H, Miyasaka N, Azuma M.
- Journal Title
  
  J. Immunol. 169
  
  Pages: 4332-4339
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Amelioration of collagen-induced arthritis by blockade of ICOS-B7h costimulation.2002
- Author(s)
  Iwai H., Kozono Y, Hirose S, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M.
- Journal Title
  
  J Immunol. 169
  
  Pages: 4332-4339
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Genetic study of SLE: lessons from mouse models.2001
- Author(s)
  Hirose S
- Journal Title
  
  Mod. Rheumatol. 11
  
  Pages: 262-262
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Structure of mouse spleen investigated by 7 color fluorescence imaging.2001
- Author(s)
  Tsurui H, Niwa S, Hirose S, Okumura K,.
- Journal Title
  
  Proc. SPIE 4259
  
  Pages: 60-67
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Reactivity of anti-PCNA murine monoclonal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation.2001
- Author(s)
  Takasaki Y, Kogure T, Takeuchi K, Kaneda K, Yano T, Hirokawa K, Hirose S, Shirai T, Hashimoto H
- Journal Title
  
  J. Immuno.l. 166
  
  Pages: 4780-4787
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Abnormal IgG galactosylation in MRL-1pr/lpr mice: pathogenic role in the development of arthritis.2001
- Author(s)
  Kuroda Y, Nakata M, Hirose S, Shirai T, Iwamoto M, Izui S, Kojima N, Mizuochi.
- Journal Title
  
  Pathol Int 51
  
  Pages: 909-915
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Susceptibility and negative epistatic loci contributing to type 2 diabetes mellitus and related phenotypes in a KK/Ta mouse model.2001
- Author(s)
  Shike T, Hirose S, Kobayashi M, Funabiki K, Shirai T, Tomino Y
- Journal Title
  
  Diatetes 50
  
  Pages: 1943-1948
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Genetic study of SLE : lessons from mouse models.2001
- Author(s)
  Hirose S., et al.
- Journal Title
  
  Mod. Rheumatol. 11
  
  Pages: 262-262
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Gain-of-function polymorphism in mouse and human Ltk : implications for the pathogenesis of systemic lupus erythematosus.
- Author(s)
  Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S
- Journal Title
  
  Hum. Mol. Genet. 13
  
  Pages: 171-179
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease, but increases the risk of B-cell chronic lymphocytic leukemia in a model of murine lupus.
- Author(s)
  Takahashi K, Abe M, Ohtsuji M, Nishimura H, Takatsu K, Shirai T, Hirose S
- Journal Title
  
  Eur. J. Immunol. 34
  
  Pages: 2740-2749
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Preferential contribution of B7-H1 to programmed death・mediated regulation of hapten-specific allergic inflammatory responses. '
- Author(s)
  Tsushima F, Iwai H, Otsuki N, Abe M, Hirose S, Yamazaki T, Akiba H, Yagita 2003 Takahashi Y, Omura K, Okumura K, Azuma M
- Journal Title
  
  Eur. J. Immunl. 33
  
  Pages: 2773-2782
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Genetic dissection of anxiety in autoimmune disease.
- Author(s)
  Nakamura K, Xiu Y, Ohtsuji M, Sugita Abe M, Ohtsuji N, Hamano Y, 2003 Jiang Y, Takahashi N, Shirai T, Nishimura H, Hirose S.
- Journal Title
  
  Hum. Mol. Genet. 12
  
  Pages: 1079-1086
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Journal Article] Toxoplasma gondii infection inhibits the development of lupus-like syndrome in autoimmune (New Zealand Black x New Zealand White) Fl mice. 200 4
- Author(s)
  Chen M, Aosai F, Norose K, Mun HS, Ishikura H, Hirose S, Piao LX, Fang H, Yano A
- Journal Title
  
  Int. Immuno1 16
  
  Pages: 937-946
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13140203
[Presentation] Role of inhibitory IgG Fc receptor IIB on B cells and monocytes in Yaa-related murine lupus.2017
- Author(s)
  Sachiko Hirose, et al.
- Organizer
  2017 UELAR ヨーロッパリウマチ学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] ループス腎炎の発症におけるIgG Fc receptor IIB欠損の役割に関する細胞レベルの解析2017
- Author(s)
  広瀬幸子、他
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Independent effect of inhibitory IgG Fc receptor IIB on B cells and monocytes on Yaa-induced murine lupus.2017
- Author(s)
  Sachiko Hirose, et al.
- Organizer
  第46回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Inhibitory IgG Fc receptor IIB on B cells and monocytes independenly controls Yaa-induced murine lupus.2016
- Author(s)
  Lin Q, Tsurui H, Nishikawa K, Amano H, Ohtsuji M, Nishimura H, Verbeek JS, Hirose S.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Blocking of CD11b+cell-migration ameliorates rheumatoid arthritis-like disease spontaneously occurring in a unique FcRIIB-deficient mouse model.2016
- Author(s)
  Mareki Otsuji,Qingshun Lin,Hideki Okazaki,Shuri Ikeda, Hinako Sasa-ki,Hirofumi Amano,Hideo Yagita,Hiroyuki Nishimura,Sachiko Hirose.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] Mechanism for cell type-specific contribution of inhibitory IgG Fc receptor IIB in Yaa-induced murine lupus.2016
- Author(s)
  Hirose S, Lin, Q, Amano H, Nishimura H, Verbeek JS
- Organizer
  10th International Congress on Autoimmunity
- Place of Presentation
  Leipzig, Germany
- Year and Date
  2016-04-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Epistatic interaction between Fcgr2b and Slam family genes in susceptibility to defective foreign protein-induced tolerance.2016
- Author(s)
  Nishimura H, Fujii T, Obata M, Ohtsuji M, Kodera Y, Takai T, Sudo K, Hirose S.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Blocking of CD11b+ cell-migration ameliorates rheumatoid arthritis-like disease spontaneously occurring in a unique FcγRIIB-deficient mouse model.2016
- Author(s)
  Ohtsuji M, Lin Q, Okazaki H, Ikeda S, Sasaki H, Amano H, Yagita H, Nishimura H, Hirose S.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Inhibitory IgG Fc Receptor IIB on B cells and monocytes independently controls Yaa-induced murine lupus.2016
- Author(s)
  Qingshun Lin,Hiromichi Tsurui,Hirofumi Amano,Keiko Nishikawa,Mareki Otsuji,Hiroyuki Nishimura, J.Sjef Verbeek, Sachiko Hirose.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] Mechanism of Phenotype Conversion from Rheumatoid Arthritis to Lupus in FcγRIIB-Deficient C57BL/6 .Yaa mice.2015
- Author(s)
  Shinya Kawano, Hirofumi Amano, Qingshun Lin, Keiko Nishikawa, Hiromichi Tsurui, Toshikazu Shirai, Sachiko Hirose, Yoshinari Takasaki.
- Organizer
  EULAR (Annual European Congress of Rheumatology)
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] SLE発症に対するFcγRIIB欠損、Slam多型およびYaa遺伝子の影響2015
- Author(s)
  西川桂子、林　青順、天野浩文、西村裕之、白井俊一、広瀬幸子
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋市、愛知県
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Dichotomy in FcγRIIb deficiency and autoimmune- prone SLAM haplotype reveals the role of SLAM haplotype in monocytosis and the significant effect of FcγRIIb deficiency in Yaa-related lupus nephritis.2015
- Author(s)
  K. Nishikawa, Q. Lin, H. Tsurui, S. Kawano, K. Kojo, H. Amano, T. Shirai, S. Hirose.
- Organizer
  Annual European Congress of Rheumatology
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] SLE発症に対するFcγRⅡB欠損、Slam多型およびYaa遺伝子の影響2015
- Author(s)
  西川桂子, 林青順, 天野浩文, 西村裕之, 白井俊一, 廣瀬幸子
- Organizer
  日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] Role of inhibitory FcγRIIb and autoimmune-prone SLAM haplotype in autoimmune disease.2015
- Author(s)
  NISHIKAWA Keiko, LIN Qingshun, TSURUI Hiromichi, AMANO Hirofumi, OKAZAKI Hideki, OHTSUJI Mareki, NISHIMURA Hiroyuki, SHIRAI Toshikazu, HIROSE Sachiko.
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌市、北海道
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] 細胞特異的FcγRIIB発現欠損マウス系の樹立によるYaa誘導ループス腎炎発症機序の解明2015
- Author(s)
  林　青順、西川桂子、大辻希樹、天野浩文、西村裕之、白井俊一、広瀬幸子
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋市、愛知県
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] 細胞特異的FcγRIIB発現欠損マウス系の樹立によるYaa誘導ループス腎炎発症機序の解明2015
- Author(s)
  林青順, 西川桂子, 大辻希樹, 天野浩文, 西村裕之, 白井俊一, 広瀬幸子
- Organizer
  日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] 関節炎自然発症FcγRIIB欠損マウスにおける抗IL-6R抗体の予防および治療効果の解析2015
- Author(s)
  大辻希樹、林　青順、西川桂子、岡崎英規、天野浩文、西村裕之、西本憲弘、白井俊一、広瀬幸子
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋市、愛知県
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Mechanism of phenotype conversion from rheumatoid arthritis to lupus in FcγRIIB-deficient C57BL/6 Yaa mice2015
- Author(s)
  Kawano S, Amano H, Q.Lin, Nishikawa K, H.T.Tsurui, Shirai T, Hirose S, Takasaki Y
- Organizer
  Annual European Congress of Rheumatology
- Place of Presentation
  ローマ、イタリア
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] Cell type-specific inhibitory IgG Fc receptor IIB in Yaa-induced murine lupus.2015
- Author(s)
  LIN Qingshun, TSURUI Hiromichi, NISHIKAWA Keiko, AMANO Hirofumi, OHTSUJI Mareki, NISHIMURA Hiroyuki, SHIRAI Toshikazu, VERBEEK J. Sjef, HIROSE Sachiko.
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌市、北海道
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Mechanism for cell type-specific contribution of inhibitory IgG Fc receptor IIB in Yaa-induced murine lupus.2015
- Author(s)
  Sachiko HIROSE, Qingshun LIN, Hiroyuki NISHIMURA, Toshikazu SHIRAI, J.Sjef.VERBEEK.
- Organizer
  The 10th international Toin Medical Engineering Symposium.
- Place of Presentation
  桐蔭横浜大学、横浜市、神奈川
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Mechanism of phenotype conversion from rheumatoid arthritis to lupus in FcγRIIB-deficient C57BL/6 Yaa mice.2015
- Author(s)
  S. Kawano, H. Amano, Q. Lin, K. Nishikawa, H.T. Tsurui, T. Shirai, S. Hirose, Y. Takasaki.
- Organizer
  Annual European Congress of Rheumatology
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice2014
- Author(s)
  Shinya Kawano, Qingshun Lin, Hirofumi Amano, Toshiyuki Kaneko, Keiko Nishikawa, Hiromichi Tsurui, Norihiro Tada, Hiroyuki Nishimura, Toshiyuki Takai, Shirai Toshikazu, Sachiko Hirose, Yoshinari Takasaki
- Organizer
  日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcgRIIB-deficient C57BL/6 mice.2013
- Author(s)
  (Oral) Sachiko Hirose, Shinya Kawano, Qingshun Lin, Hirofumi Amano, Toshiyuki Kaneko, Keiko Nishikawa, Hiromichi Tsurui, Hiroyuki Nishimura, Toshikazu Shirai.
- Organizer
  15th International Congress of Immunology,
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Peripheral tolerance of antigen-specific Th cells induced with polyethylene glycol-conjugate of protein antigen.2013
- Author(s)
  (口頭) OBATA Masaomi, OHTSUJI Mareki, SHIRAI Toshikazu, HIROSE Sachiko, NISHIMURA Hiroyuki.
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Thorough characterization of TCR-pMHC binding free energy estimated by string model and Miyazawa-Jernigan matrix (III).2013
- Author(s)
  TSURUI Hiromichi, HIROSE Sachiko.
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] B cell specific deficiency of FcgRIIB results in high levels of autoantibodies without severe lupus nephritis in C57BL/6.Yaa mice.2013
- Author(s)
  (口頭) LIN Qingshun, NISHIKAWA Keiko, TSURUI Hiromichi, OKAZAKI Hideki, OHTSUJI Mareki, NISHIMURA Hiroyuki, AMANO Hirofumi, SHIRAI Toshikazu, HIROSE Sachiko.
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Cd72c is a modifier gene that regulates FASlpr-induced autoimmune disease.2013
- Author(s)
  (口頭) XU Miduo, HIROSE Sachiko, ADACHI Takahiro, TSUBATA Takeshi.
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Characterization of TCR-pMHC interaction based on string model and Miyazawa-Jernigan matrIX2013
- Author(s)
  Hiromichi Tsurui, Sachiko Hirose
- Organizer
  15th International Congress of Immunology,
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice.2013
- Author(s)
  Shinya Kawano, Toshiyuki Kaneko, Aya Sato- Hayashizaki, Lin Qingshun, Hirofumi Amano. Sachiko Hirose, Yoshinari Takasaki.
- Organizer
  5th East Asian Group of Rheumatology.
- Place of Presentation
  ソウル、韓国
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] FcγレセプターIIB欠損マウスを用いたRAとSLEの特異性を決める遺伝的要因の解析2013
- Author(s)
  天野浩文, 金子俊之, 河野晋也, 林青順, 西川桂子, 鶴井博理, 大辻希樹, 西村裕之, 広瀬幸子, 髙崎芳成
- Organizer
  第41回日本臨床免疫学会総会
- Place of Presentation
  下関
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] Clarification of　the　role　of　FcgRIIB　for　autoimmune　disease using　the　cell-specific　FcgRIIB　conditional knockout　mice.2013
- Author(s)
  Qingshun Lin, Hirofumi Amano, Hiroyuki Nishimura, Keiko Nishikawa, Sachiko Hirose.
- Organizer
  第57回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Clarification of the role of FcgRIIB for autoimmune disease using the cellspecific FcgRIIB conditionalkanockout mice2013
- Author(s)
  Qingshun Lin, Hirofumi Amano, Hiroyuki Nishimura, Keiko Nishikawa, Sachiko Hirose
- Organizer
  第57回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] A novel locus of B6 mice on chromosome 12 plays a role in common process shared by SLE, RA, and Sjögren syndrome.2013
- Author(s)
  Toshiyuki Kaneko, Hirofumi Amano, Mareki Ohtsuji, Keiko Nishikawa, Shinya Kawano, Naomi Ohtsuji, Qingshun Lin, Hideki Okazaki, Hiromichi Tsurui, Hiroyuki Nishimura, Toshikazu Shirai, Yoshinori Takasaki, and Sachiko Hirose.
- Organizer
  5th East Asian Group of Rheumatology
- Place of Presentation
  ソウル,韓国
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Peripheral tolerance of antigen-specific Th cell induced with polyethylene glycol-conjugate of protein antigen.2013
- Author(s)
  Obata M, Ohtsuji M, Shirai T, Hirose S, Nishimura H.
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ、千葉市
- Data Source
  KAKENHI-PROJECT-23591450
[Presentation] Blockade of TNFa, but not IL-17, ameliorates spontaneously occurring autoimmune arthritis in FcgRIIB-deficient mice.2013
- Author(s)
  OKAZAKI Hideki, LIN Qingshun, NISHIKAWA Keiko, TSURUI Hiromichi, OHTSUJI Mareki, NISHIMURA Hiroyuki, SHIRAI Toshikazu, HIROSE Sachiko.
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Mechanism of Th cell tolerance induced with tolerogenic polyethylene glycol(PEG)-conjugate of protein antigen.2012
- Author(s)
  OBATA Masaomi, OHTSUJI Mareki, SHIRAI Toshikazu, HIROSE Sachiko, NISHIMURA Hiroyuki.
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Mechanism of Th-cell tolerance induced with the tolerogenic protein antigen conjugated with polyethylene glycol2012
- Author(s)
  Obata M, Kodera Y, Ohtsuji M, Shirai T, Hirose S, Nishimura H.
- Organizer
  Toin International Symposium on Biomedical Engineering 2012,
- Place of Presentation
  Toin University of Yokohama, Aoba-ku Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23591450
[Presentation] A novel locus of B6 mice on chromosome 12 plays a role in common process shared by SLE, RA and Sjogren syndrome.2012
- Author(s)
  Kaneko T, Amano H, Ohtsuji M, Nishikawa K, Shinya K, Ohtsuji M, Lin Q, Okazaki H, Tsurui H, Nishimura H, Shirai T, Takasaki Y, Hirose S.
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  神戸国際会議場、神戸
- Data Source
  KAKENHI-PROJECT-23591450
[Presentation] The role of SAP-signal in SLE.2012
- Author(s)
  LIN Qingshun, TSURUI Hiromichi, NISHIKAWA Keiko, OKAZAKI Hideki, OHTSUJI Mareki, NISHIMURA Hiroyuki, ONO Masao, SHIRAI Toshikazu, HIROSE Sachiko.
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] FcγレセプターIIB欠損マウスにおけるYaa遺伝子の与える影響2012
- Author(s)
  河野晋也、天野浩文、金子俊之、佐藤綾、林青順、広瀬幸子、高崎芳成
- Organizer
  第56回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Thorough characterization of TCR-pMHC binding free energy estimated by string model and Miyazawa-Jernigan matrix.2012
- Author(s)
  TSURUI Hiromichi, HIROSE Sachiko.
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Effect of SAP-deficiency on B cell-mediated autoimmune disease2012
- Author(s)
  Qingshun Lin, Mareki Ohtsuji, Aya Hayashizaki, Hiroyuki Nishimura, Masao Ono, Sachiko Hirose
- Organizer
  第56回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] A novel locus of B6 mice on chromosome 12 plays a role in common process shared by SLE, RA, and Sjogren syndrome.2012
- Author(s)
  KANEKO Toshiyuki, AMANO Hirofumi, KAWANO Shinya, Lin Qingshun, OKAZAKI Hideki, TSURUI Hiromichi, NISHIMURA Hiroyuki, SHIRAI Toshikazu, TAKASAKI Yoshinari, HIROSE Sachiko.
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] The role of SLAM-signal in SLE.2012
- Author(s)
  Lin Q, Tsurui H, Nishikawa K, Okazaki H, Ohtsuji M, Nishimura H, Ono M, Shirai T, Hirose S.
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  神戸国際会議場、神戸
- Data Source
  KAKENHI-PROJECT-23591450
[Presentation] 重篤な関節リウマチを自然発症するFcγレセプターIIB欠損マウスの樹立2012
- Author(s)
  広瀬幸子、佐藤綾、林青順、天野浩文、大辻希樹、西村裕之
- Organizer
  第56回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Mechanism of Th cell tolerance induced with tolerogenic polyethylene glycol(PEG)-conjugate of protein antigen2012
- Author(s)
  Obata M, Ohtsuji M, Shirai T, Hirose S, Nishimura H.
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  神戸国際会議場、神戸
- Data Source
  KAKENHI-PROJECT-23591450
[Presentation] Phenotype conversion from RA to SLE in FcgRIIB-deficient B6 mice by Yaa mutation.2012
- Author(s)
  Kawano S, Amano H, Lin Q, Kaneko T, Nishikawa K, Okazaki H, Tsurui H, Nishimura H, Shirai T, Takasaki Y, Hirose S
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  神戸国際会議場、神戸
- Data Source
  KAKENHI-PROJECT-23591450
[Presentation] Phenotype conversion from RA to SLE in FcγRIIB-deficient B6 mice by Yaa mutation.2012
- Author(s)
  KAWANO Shinya, AMANO Hirofumi, LIN Qingshun, KANEKO Toshiyuki, NISHIKAWA Keiko, OKAZAKI Hideki, TSURUI Hiromichi, NISHIMURA Hiroyuki, SHIRAI Toshikazu, TAKASAKI Yoshinari, HIROSE Sachiko
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Servival of antigen-derived germinal center B-cell is controlled by centrocyte-associated expression of apoptosis-regulator G5PR.2012
- Author(s)
  KITABATAKE Masahiro, TODA Teppei, KUWAHARA Kazuhiro, IGARASHI Hideya, OHTSUJI Mareki, HIROSE Sachiko, SAKAGUCHI Nobuo
- Organizer
  第41回日本免疫学会総会・学術集会.
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] ポリエチレングリコール修飾抗原によって誘導されるTh細胞免疫寛容の機序・Mechanism of Th-cell tolerance induced with tolerogenic protein antigen conjugated with polyethylene glycol.2011
- Author(s)
  藤原龍、尾畑賢臣、藤井琢磨、大辻希樹、小寺洋、広瀬幸子、西村裕之
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ、千葉市
- Data Source
  KAKENHI-PROJECT-23591450
[Presentation] SLEにおけるSLAMシグナルの役割・The role of SLAM signal in SLE2011
- Author(s)
  林青順、大辻希樹、佐藤綾、大辻奈穂美、西川桂子、鶴井博理、須藤カツ子、西村裕之、小野栄夫、白井俊一、広瀬幸子
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ、千葉市
- Data Source
  KAKENHI-PROJECT-23591450
[Presentation] Presumptive role of 129 strain-derived Sle16 locus for rheumatoid arthritis in a new mouse model with FcgRIIB-deficient C57BL/6 genetic background.2011
- Author(s)
  Sato A, Ohtsuji M, Lin Q, Ohtsuji N, Nishikawa K, Tsurui H, Ono M, Shirai T, Takai T, Nishimura H, Hirose S.
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  幕張メッセ、千葉市
- Data Source
  KAKENHI-PROJECT-23591450
[Presentation] BXSBマウスの末梢血単球増加におけるFcγレセプターの役割2008
- Author(s)
  天野浩文、天野恵理、安藤誠一郎、仲野総一郎、森本真司、戸叶嘉明、林青順、西村裕之、広瀬幸子、高崎芳成
- Organizer
  第52回日本リウマチ学会総会・学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19591181
[Presentation] FcgR-dependent expansion of Gr-1- monocyte subset in lupus prone mice2008
- Author(s)
  Amano H, Amano E, Lin Q. Ando S, Nishimura H, Moromoto S, Hirose S, Takasaki Y
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591181
[Presentation] SLE動物モデルにおけるT細胞の活性化2008
- Author(s)
  藤尾圭志、岡本明子、鶴井博理、広瀬幸子、山本一彦
- Organizer
  第52回日本リウマチ学会総会・学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19591181
[Presentation] 抑制型IgG FcレセプターによるB細胞分化の制御2008
- Author(s)
  林青順、天野浩文、天野恵理、白井俊一、広瀬幸子
- Organizer
  第52回日本リウマチ学会総会・学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19591181
[Presentation] (NZW x BXSB) F1マウスにおけるFcgr2bプロモーター領域の多型性の影響2008
- Author(s)
  Lin Q、Tsurui H, Ohtsuji M, Amano H、Nishimura H, Shirai T, Hirose S
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591181
[Presentation] Association of NKT cell function with systemic lupus erythematosus2007
- Author(s)
  Hirose S, Tsukamoto K, Ohtsuj M, Lin Q, Tsurui H, Nishimura H, Shirai T
- Organizer
  第37回日本免疫学会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591181
[Presentation] 末梢性の免疫寛容誘導における抑制性Fc受容体FcgRIIBの役割2007
- Author(s)
  軸丸由梨、藤井琢磨、池田賢一、大木麻紀子、吉澤侑也、小寺洋、広瀬幸子、白井俊一、西村裕之
- Organizer
  第37回日本免疫学会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591181
[Presentation] BXSBマウスの末梢血単核球増加におけるIgGFcレセプターの役割2007
- Author(s)
  天野浩文、天野恵理、安藤誠一郎、仲野総一郎、森本真司、戸叶嘉明、林青順、西村裕之、広瀬幸子、高崎芳成
- Organizer
  第37回日本免疫学会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591181
[Presentation] Protection from autoimmune disease by restoration of impaired FcgRIIB expression2007
- Author(s)
  Lin Q, Ohtsuji M, Amano H, Amano E, Tsurui H, Nishimura H, Shirai T, Hirose S
- Organizer
  第37回日本免疫学会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591181
[Presentation] Mechanism of phenotype conversion from rheumatoid arthritis to lupus in FcγRIIB-deficient C57BL/6 Yaa mice
- Author(s)
  S. Kawano, H. Amano, Q. Lin, K. Nishikawa , H. Tsurui, T. Shirai, S. Hirose, Y. Takasaki
- Organizer
  The European League Against Rheumatism
- Place of Presentation
  ローマ、イタリア
- Year and Date
  2015-06-10 – 2015-06-13
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] Phenotype conversion from rheumatoid arthritis to systetmic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice.
- Author(s)
  Shinya Kawano, Qingshun Lin, Hirofumi Amano, Toshiyuki Kaneko, Keiko Nishikawa, Hiromichi Tsurui, Norihiro Tada, Hiroyuki Nishimura, Toshiyuki Takai, Toshikazu Shirai, Sachiko Hirose, Yoshinari Takasaki.
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京、グランドプリンスホテル新高輪
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] TNFα and IL-6 but not IL-17 are critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcγRIIB-deficient mouse model.
- Author(s)
  OHTSUJI Mareki, OKAZAKI Hideki, LIN Qingshun, NISHIKAWA Keiko, NISHIMURA Hiroyuki, AMANO Hirofumi, NISHIMOTO Norihiro, SHIRAI Toshikazu, HIROSE Sachiko.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都、京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] IL-6 signal blockade ameriolates spontaneous occurring rheumatoid arthritis in an FcγRIIB-deficient mouse model through loss of the receptor activator of NF-κB ligand/osteoprotegerin balance.
- Author(s)
  Mareki Ohtsuji, Qingshun Lin, Keiko Nishikawa, Hideki Okazaki, Hiroyuki Nishimura, Norihiro Nishimoto, Sachiko Hirose.
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京、グランドプリンスホテル新高輪
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] B cell specific deficiency of FcγRIIB is required for autoantibody production, but not enough for early onset of lupus nephritis in B6.Yaa mice.
- Author(s)
  Qingshun Lin, Keiko Nishikawa, Mareki Ohtsuji, Hiroyuki Nishimura, Hirofumi Amano, Sachiko Hirose.
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京、グランドプリンスホテル新高輪
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] B cell specific FcγRIIb deficiency is enough for autoantibody production, but not for the progression of Yaa-related lupus nephritis.
- Author(s)
  LIN Qingshun, TSURUI Hiromichi, NISHIKAWA Keiko, AMANO Hirofumi, OHTSUJI Mareki, NISHIMURA Hiroyuki, SHIRAI Toshikazu, VERBEEK Sjef, HIROSE Sachiko.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都、京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Genetic dissection of FcγRIIb deficiency and autoimmune-type SLAM haplotype reveals the important role of FcγRIIb in Yaa-related lupus nephritis.
- Author(s)
  NISHIKAWA Keiko, LIN Qingshun, TSURUI Hiromichi, AMANO Hirofumi, NISHIMURA Hiroyuki, SHIRAI Toshikazu, TAKAI Tosjiyuki, HIROSE Sachiko.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都、京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Gene expression profile in spleen cells of (NZB x NZW) F1 mice with overt SLE activity.
- Author(s)
  HIRONO Fusako, OBATA Masaomi, KODERA Yo, OHTSUJI Mareki, SHIRAI Toshikazu, HIROSE Sachiko, NISHIMURA Hiroyuki.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都、京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590491

1. HAMANO Yoshitomo (10281354)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. NISHIMURA Hiroyuki (60189313)

# of Collaborated Projects: 6 results

# of Collaborated Products: 39 results
3. ZHANG Danqing (40296877)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. JIANG Yi (50276466)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
5. AMANO Hirofumi (50318474)

# of Collaborated Projects: 4 results

# of Collaborated Products: 38 results
6. SHIRAI Toshikazu (30115860)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. WAKIYA Midori (00220848)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. UEDA Genjiroh (90203439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TSURUI Hiromichi (40217386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. SAKAGUCHI Shimon (30280770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. INABA Kayo (00115792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KIKUTANI Hitoshi (80161412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. AZUYMA Miyuki (90255654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
14. MATSUOKA Shuji (20286743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. KODERA Yo (80205426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. OKADA Takashi (20185440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKASAKI Yoshinari (80154772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 三井健一 (80266030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 中村和裕 (10327835)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 大辻希樹 (30398664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. 徳重克年 (60188729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 野口一雄 (10208316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 中野直子 (90222166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 高橋武司 (80335215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
25. 多田昇弘 (50338315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 上野博夫 (60332368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. INUI Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 鍔田武志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 高井俊行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIROSE Sachiko 広瀬 幸子

広瀬 幸子 ヒロセ サチコ

廣瀬 幸子 ヒロセ サチコ

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Role of FcgRIIB for autoantibody production inside and outside of germinal centersPrincipal Investigator

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Epistatic interaction of FcgammaRIIB and Sle16 polymorphism in rheumatoid arthritisPrincipal Investigator

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A novel regulatory role of IgG Fc receptor IIB in Flt3L-mediated dendritic cell developmentPrincipal Investigator

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Role of G-CSF and C-CSF receptor gene polymorphisms for the development of lupus nephritisPrincipal Investigator

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Ltk gene polymorphism and aberrant activation of autoreactive B cellsPrincipal Investigator

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自己反応性B細胞の寛容破綻に関わる遺伝的機構とその制御Principal Investigator

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HIROSE Sachiko 広瀬幸子

広瀬幸子ヒロセサチコ

廣瀬幸子ヒロセサチコ