TANIGUCHI Takanobu 谷口隆信

Researcher Number	60217130
Affiliation (based on the past Project Information) *help	2013 – 2022: 旭川医科大学, 医学部, 教授 2002 – 2006: 旭川医科大学, 医学部, 教授 1997 – 2001: 福井医科大学, 医学部, 助教授 1989 – 1994: 福井医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related / General pharmacology / Pathological medical chemistry Except Principal Investigator General pharmacology / Pathological medical chemistry / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 47040:Pharmacology-related / Obstetrics and gynecology / Biophysics / Structural biochemistry / General medical chemistry
Keywords	Principal Investigator Her2 / syk / IGF2 / KIP2 / ムスカリン受容体 / MAP kinase / 炎症性腸疾患 / TACE / 腸上皮バリア / TNF-α … More / ADAM17 / SOCE / STIM1 / ADM17 / p38 / TNF / protein-tyrosine kinase / breast cancer / cancer / タンパク質チロシンキナーゼ / 乳癌 / 癌 / indomethacin / endothelin / Ductuc Artenosus / インドメサシン / エンドセリン / 動脈管 / imprinting / urogenital tumour / Wilms tumour / kip2 / 細胞周期 / 精巣腫瘍 / 前立腺癌 / 膀胱癌 / インプリンティング / 泌尿生殖器腫瘍 / Wilms腫瘍 / acetylcholine / acetylchoine / focal　adhesion　kinase / 上皮バリア / muscarinic cholinoceptor / intestinal barrier / focal adhesion kinase … More Except Principal Investigator Lyn / Syk / チロシンキナーゼ / p72syk / 血小板 / 脾臓 / 幹細胞 / 顆粒膜細胞 / ムスカリン受容体 / トロンビン / PLCγ / PI3キナーゼ / Shc / Thrombin / Protein-tyrosine kinase / Ca^<2+> / SH2 / スロンビン / neutral antagonist / inverse agonist / α_1アドレナリン受容体 / 逆作用薬 / Cキナ-ゼ / 核内受容体 / 顆粒膜細胞ｙ / 転写 / ステロイドホルモン / エンハンサー / LRH-1 / シグナル情報伝達系 / MAP kinase / acetylcholine / GPCR / 細胞内受容体 / トランスポーター / アセチルコリン / DNAマイクロアレイ / SF-1 / CYP19A1 / 一酸化窒素 / SF-1/Ad4BP / porcine aorta smooth muscle / chimeric essential light chain / 4 domains of essential light chain / essential light chain / phosphorylation-dependent regulatio / filament assembly / conformational transition / smooth muscle myosin / ブタ大動脈平滑筋 / キメラ必須軽鎖 / 必須軽鎖の四つのドメイン / 必須軽鎖 / リン酸化依存調節 / フィラメント形成 / コンホメーション変換 / 平滑筋ミオシン / dephosphorylation / protein phosphatase / CaM kinase / 抗体 / ファーウエスタンブロッティング / 相互作用解析 / 結合タンパク質 / GAPDH / アポトーシス / 胚発生 / ノックダウン / アンチセンスRNA / ゼブラフィッシュ / CaMキナーゼIV / 脱リン酸化 / プロテインホスファターゼ / CaMキナーゼ / constitutive activity / supersensitivity / tolerance_ / α_1adrenoceptor / 相互作用 / 構成的活性化 / 過敏反応 / トレランス / ニュートラルアンタゴニスト / インバースアゴニスト / Development / Rat neonate brain / Choline transporter / Muscarinic receptor / Nicotine / コリントランスポータ- / 発達 / ラット新生仔脳 / コリントランスポーター / ニコチン / cytosensor / splice variants / molecular cloning / alpha_1 adrenoceptor / 組織分布 / 塩基配列 / スプライスバリアント / クローニング / α_1アドレナリン受容体サブタイプ / PI 3 kinase / Interleukin2 / PLCgamma / Tyrosine kinase / 活性化機構 / コンカナバリンA / トロンボキサンA_2 / インターロイキン2 / mast cell / FcgammaRIIIA / IgE receptor / B cell receptor / DT-40 cell / B細胞受容体 / IgE受容体 / GAP / RBL-2H3細胞 / DT40細胞 / Wheat germ agglutinin / Myosin light chain kinase / Calmodulin / Platelets / P72syk / ミエリン塩基性蛋白質 / 自己燐酸化 / 40Kチロシンキナ-ゼ / 蛋白質分解酵素 / 細胞質チロシンキナ-ゼ / 蛋白質チロシン残基燐酸化酵素 / カルモジュリン / H2Bヒストン / down-regulation / thronbin / spleen / serine kinase / vanadate / platelets / C-kinase / tyrosine kinase / セロトニン放出反応 / ダウンレギュレ-ション / セリンキナ-ゼ / バナジン酸 / チロシンキナ-ゼ / upregulation / 中性拮抗薬 / 組換え受容体 / サイトセンサー / α_<1a>アドレナリン受容体 / ヒストキナ-ゼ / pH / イオン強度 / トリプシン様プロテア-ゼ / 限定分解 / Cキナーゼ / ブタ / ポリ塩基性アミノ酸 / ポリアミン Less

Functional roles of intracellular muscarinic acetylcholine receptors in vivo
- Principal Investigator
  
  UWADA Junsuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kanazawa Medical University
  Asahikawa Medical College
Induction of steroidogenic cells from stem cells based on the regulation of LRH-1 expression
- Principal Investigator
  
  Yazawa Takashi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Asahikawa Medical College
Reinforcement of colonic epithelial barrier via mAChRPrincipal Investigator
- Principal Investigator
  
  Taniguchi Takanobu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Asahikawa Medical College
Induction of ovarian granulosa cells from mesenchymal stem cells for investigating the molecular mechanisms of their development.
- Principal Investigator
  
  Yazawa Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Asahikawa Medical College
Maintenance of intestinal barrier function by focal adhesion kinasePrincipal Investigator
- Principal Investigator
  
  TANIGUCHI Takanobu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Asahikawa Medical College
Analysis of Signal Transduction Pathway of Syk in Breast Cancer Cells-as a comparison with that of Her2Principal Investigator
- Principal Investigator
  
  TANIGUCHI Takanobu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Asahikawa Medical College
A functional site of the essential light chain involved in the regulation of filament assembly of smooth muscle myosin.
- Principal Investigator
  
  KATOH Tsuyoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Asahikawa Medical College
Enzymatic study of CaM kinase phosphatase for elucidation of its biological function
- Principal Investigator
  
  TAKEUCHI Masayuki, ISHIDA Atsuhiko
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Asahikawa Medical College
Role of endothelin in the physiological closure of Ductus ArtenosusPrincipal Investigator
- Principal Investigator
  
  TANIGUCHI Takanobu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Asahikawa Medical College
Pharmacological evaluation of inverse agonists and neutral antagonists
- Principal Investigator
  
  URAMATSU Ikunobu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Fukui Medical University
Effect of nicotine administration on development of muscarinic receptor in central nervous system of rat neonatePrincipal Investigator
- Principal Investigator
  
  TANIGUCHI Takanobu, 朱軍
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Fukui Medical University
組換え受容体を用いた逆作用薬inverse agonistの検索
- Principal Investigator
  
  村松郁延
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  福井医科大学
Relaxation of IGF2 and KIP2 imprinting in Wilms tumours and other urogenital tumoursPrincipal Investigator
- Principal Investigator
  
  TANIGUCHI Takanobu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Fukui Medical University
組換え受容体を用いた逆作用薬inverse agonistの検索
- Principal Investigator
  
  MURAMATSU Ikunobu
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  福井医科大学
Molecular cloning and functional studies of alpha_1 adrenoceptors
- Principal Investigator
  
  MURAMATSU Ikunobu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Fukui Medical University
Physiological role of protein-tyrosine kinase p72^<syk>
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kobe University
  福井医科大学
Physiological function of non-receptor type protein-tyrosine kinase p72^<syk>
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KOBE UNIBERSITY
  福井医科大学
Activation of cytosolic protein-tyrosine kinase and analysis of its substrate proteins
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Fukui Medical School
細胞の癌化における蛋白質燐酸化酵素の役割
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  福井医科大学
Ca^<2+>・燐脂質依存性蛋白質燐酸化酵素(Cキナ-ゼ)の基質認識について
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  福井医科大学
Role of Protein-Tyrosine Kinases and Protein-Serine Kinases in Intracellular Signal Transduction
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukui Medical School

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2006 2005

All Journal Article Presentation Patent

[Journal Article] Pleiotropic effects of probenecid on three-dimensional cultures of prostate cancer cells2021
- Author(s)
  Uwada Junsuke、Mukai Shoichiro、Terada Naoki、Nakazawa Hitomi、Islam Mohammad Sayful、Nagai Takahiro、Fujii Masato、Yamasaki Koji、Taniguchi Takanobu、Kamoto Toshiyuki、Yazawa Takashi
- Journal Title
  
  Life Sciences
  
  Volume: 278 Pages: 119554-119554
- DOI
  10.1016/j.lfs.2021.119554
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794
[Journal Article] Evaluation of radiolabeled acetylcholine synthesis and release in rat striatum2021
- Author(s)
  Muramatsu Ikunobu、Uwada Junsuke、Chihara Kazuyasu、Sada Kiyonao、Wang Mao‐Hsien、Yazawa Takashi、Taniguchi Takanobu、Ishibashi Takaharu、Masuoka Takayoshi
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 160 Issue: 3 Pages: 342-355
- DOI
  10.1111/jnc.15556
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794, KAKENHI-PROJECT-20K07354, KAKENHI-PROJECT-20K09814
[Journal Article] Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways2020
- Author(s)
  Mikami Daisuke、Kobayashi Mamiko、Uwada Junsuke、Yazawa Takashi、Kamiyama Kazuko、Nishimori Kazuhisa、Nishikawa Yudai、Nishikawa Sho、Yokoi Seiji、Kimura Hideki、Kimura Ikuo、Taniguchi Takanobu、Iwano Masayuki
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 1865 Issue: 6 Pages: 158666-158666
- DOI
  10.1016/j.bbalip.2020.158666
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794, KAKENHI-PROJECT-20K07844, KAKENHI-PROJECT-20H03696, KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-18K15971
[Journal Article] AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis via HDAC inhibition2020
- Author(s)
  Mikami Daisuke、Kobayashi Mamiko、Uwada Junsuke、Yazawa Takashi、Kamiyama Kazuko、Nishimori Kazuhisa、Nishikawa Yudai、Nishikawa Sho、Yokoi Seiji、Taniguchi Takanobu、Iwano Masayuki
- Journal Title
  
  Therapeutic Advances in Medical Oncology
  
  Volume: 12 Pages: 1-13
- DOI
  10.1177/1758835920913432
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794, KAKENHI-PROJECT-18K06946
[Journal Article] Evaluation of 17β-hydroxysteroid dehydrogenase activity using androgen receptor-mediated transactivation2020
- Author(s)
  Yazawa Takashi、Imamichi Yoshitaka、Uwada Junsuke、Sekiguchi Toshio、Mikami Daisuke、Kitano Takeshi、Ida Takanori、Sato Takahiro、Nemoto Takahiro、Nagata Sayaka、Islam Khan Md. Rafiqul、Takahashi Satoru、Ushikubi Fumitaka、Suzuki Nobuo、Umezawa Akihiro、Taniguchi Takanobu
- Journal Title
  
  The Journal of Steroid Biochemistry and Molecular Biology
  
  Volume: 196 Pages: 105493-105493
- DOI
  10.1016/j.jsbmb.2019.105493
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06312, KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K08543, KAKENHI-PROJECT-19K09794, KAKENHI-PROJECT-17K08124, KAKENHI-PROJECT-17K11214, KAKENHI-PROJECT-18K06946
[Journal Article] β-Hydroxybutyrate enhances the cytotoxic effect of cisplatin via the inhibition of HDAC/survivin axis in human hepatocellular carcinoma cell2020
- Author(s)
  Daisuke Mikami, Mamiko Kobayashi, Junsuke Uwada, Takashi Yazawa, Kazuko Kamiyama, Kazuhisa Nishimori, Yudai Nishikawa, Sho Nishikawa, Seiji Yokoi, Takanobu Taniguchi, and Masayuki Iwano
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 142 Issue: 1 Pages: 1-8
- DOI
  10.1016/j.jphs.2019.10.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-19K07117
[Journal Article] PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK2020
- Author(s)
  Uwada Junsuke、Nakazawa Hitomi、Mikami Daisuke、Islam Mohammad Sayful、Muramatsu Ikunobu、Taniguchi Takanobu、Yazawa Takashi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 182 Pages: 114297-114297
- DOI
  10.1016/j.bcp.2020.114297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794, KAKENHI-PROJECT-18K06946
[Journal Article] Augmentation of endogenous acetylcholine uptake and cholinergic facilitation of hippocampal long-term potentiation by acetylcholinesterase inhibition2019
- Author(s)
  Masuoka T, Uwada J, Kudo M, Yoshiki H, Yamashita Y, Taniguchi T, Nishio M, Ishibashi T, Muramatsu I
- Journal Title
  
  Neuroscience
  
  Volume: 404 Pages: 39-47
- DOI
  10.1016/j.neuroscience.2019.01.042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-17K16992, KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-16K19023
[Journal Article] Transcriptional Regulation of Ovarian Steroidogenic Genes; Recent Findings Obtained from Stem Cell-derived Steroidogenic Cells.2019
- Author(s)
  Yazawa, T., Imamichi, Y., Sekiguchi, T., Miyamoto, K., Uwada, J., Khan, R., Suzuki, N., Umezawa A. and Taniguchi, T.
- Journal Title
  
  BioMed Research International
  
  Volume: 8973076 Pages: 1-13
- DOI
  10.1155/2019/8973076
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06312, KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-19K09794, KAKENHI-PROJECT-17K11214
[Journal Article] β-Hydroxybutyrate, a ketone body, reduces the cytotoxic effect of cisplatin via activation of HDAC5 in human renal cortical epithelial cells.2019
- Author(s)
  Mikami D, Kobayashi M, Uwada J, Yazawa T, Kamiyama K, Nishimori K, Nishikawa Y, Morikawa Y, Yokoi S, Takahashi N, Kasuno K, Taniguchi T, Iwano M.
- Journal Title
  
  Life Sci
  
  Volume: 222 Pages: 125-132
- DOI
  10.1016/j.lfs.2019.03.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09692, KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-19K09794
[Journal Article] Nicotinic Acetylcholine Receptor-Mediated Signaling Pathways in Pluripotent Stem Cells2019
- Author(s)
  Takashi Yazawa, Junsuke Uwada, Yoshitaka Imamichi, Daisuke Mikami, Takahiro Sato, Rafiqul Islam Khan, Mohammad Sayful Islam and Takanobu Taniguchi
- Journal Title
  
  American Journal of Biomedical Science & Research
  
  Volume: 6 Issue: 5 Pages: 361-363
- DOI
  10.34297/ajbsr.2019.06.001061
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-19K09794
[Journal Article] Cyclooxygenase‐2 is acutely induced by CCAAT/enhancer‐binding protein β to produce prostaglandin E 2 and F 2α following gonadotropin stimulation in Leydig cells2019
- Author(s)
  Yazawa Takashi、Imamichi Yoshitaka、Yuhki Koh‐ichi、Uwada Junsuke、Mikami Daisuke、Shimada Masayuki、Miyamoto Kaoru、Kitano Takeshi、Takahashi Satoru、Sekiguchi Toshio、Suzuki Nobuo、Rafiqul Islam Khan Md.、Ushikubi Fumitaka、Umezawa Akihiro、Taniguchi Takanobu
- Journal Title
  
  Molecular Reproduction and Development
  
  Volume: 86 Issue: 7 Pages: 786-797
- DOI
  10.1002/mrd.23163
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06312, KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794, KAKENHI-PROJECT-17K11214
[Journal Article] Novel regulatory systems for acetylcholine release in rat striatum and anti‐Alzheimer's disease drugs2019
- Author(s)
  Muramatsu Ikunobu、Uwada Junsuke、Yoshiki Hatsumi、Sada Kiyonao、Lee Kung‐Shing、Yazawa Takashi、Taniguchi Takanobu、Nishio Matomo、Ishibashi Takaharu、Masuoka Takayoshi
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 印刷中 Issue: 5 Pages: 605-623
- DOI
  10.1111/jnc.14701
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-16K19023, KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-19K09794
[Journal Article] Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells.2019
- Author(s)
  Uwada J, Yazawa T, Mikami D, Krug SM, Fromm M, Yoshiki H, Sada K, Muramatsu I, Taniguchi T.
- Journal Title
  
  Cell signal.
  
  Volume: 63 Pages: 109358-109358
- DOI
  10.1016/j.cellsig.2019.109358
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-19K07117, KAKENHI-PROJECT-19K09794
[Journal Article] A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signaling pathways in HepG2 cells2018
- Author(s)
  Kobayashi M, Mikami D, Uwada J, Yazawa T, Kamiyama K, Kimura H, Taniguchi T, Iwano M
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 59 Pages: 31342-31354
- DOI
  10.18632/oncotarget.25809
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06946, KAKENHI-PROJECT-16K08931, KAKENHI-PROJECT-16K19012
[Journal Article] Diethylstilbestrol administration inhibits theca cell androgen and granulosa cell estrogen production in immature rat ovary2017
- Author(s)
  Imamichi, Y., Sekiguchi, T., Kitano, T., Kajitani, T., Okada, R., Inaoka, Y., Miyamoto, K., Uwada, J., Takahashi, S., Nemoto, T., Mano, A., Khan, M.R.I., Islam, M.T., Yuhki, K., Kashiwagi, H., Ushikubi, F., Suzuki, N., Taniguchi, T., Yazawa, T.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 8374-8374
- DOI
  10.1038/s41598-017-08780-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07420, KAKENHI-PROJECT-17K11214, KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-15K10654, KAKENHI-PROJECT-16K14766
[Journal Article] Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK2017
- Author(s)
  Uwada Junsuke、Yazawa Takashi、Islam Md Tariqul、Khan Md Rafiqul Islam、Krug Susanne M.、Fromm Michael、Karaki Shin-ichiro、Suzuki Yuichi、Kuwahara Atsukazu、Yoshiki Hatsumi、Sada Kiyonao、Muramatsu Ikunobu、Taniguchi Takanobu
- Journal Title
  
  Cellular Signalling
  
  Volume: 35 Pages: 188-196
- DOI
  10.1016/j.cellsig.2017.04.007
- NAID
  120006491645
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08656, KAKENHI-PROJECT-16K19012, KAKENHI-PROJECT-15K08182, KAKENHI-PROJECT-15K08250, KAKENHI-PROJECT-15K10654
[Journal Article] 11-ketotestosterone is a major androgen produced in human gonads2016
- Author(s)
  Imamichi, Y., Yuhki, K.-I., Orisaka, M., Kitano, T., Mukai, K., Ushikubi, F., Taniguchi, T., Umezawa, A., Miyamoto, K., Yazawa, T.
- Journal Title
  
  J. Clin. Endocrinol. Metab.
  
  Volume: 101 Issue: 10 Pages: 3582-3591
- DOI
  10.1210/jc.2016-2311
- NAID
  120006348221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461387, KAKENHI-PROJECT-15K10654
[Journal Article] Induction of steroidogenic cells from adult stem cells and pluripotent stem cells [Review]2016
- Author(s)
  1.Yazawa, T., Imamichi, Y., Miyamoto, M., Khan, MR., Uwada, J., Umezawa, A., Taniguchi, T.:
- Journal Title
  
  Endocr J
  
  Volume: 63 Issue: 11 Pages: 943-951
- DOI
  10.1507/endocrj.EJ16-0373
- NAID
  130005170487
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10654, KAKENHI-PROJECT-16K19012
[Journal Article] Differentiation of mesenchymal stem cells into gonad and adrenal steroidogenic cells.2015
- Author(s)
  Yazawa T, Imamichi Y, Miyamoto K, Umezawa A, Taniguchi T.
- Journal Title
  
  World J Stem Cells
  
  Volume: 6 Pages: 203-212
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460378
[Journal Article] Activation of focal adhesion kinase via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial injury.2015
- Author(s)
  Khan RI, Yazawa T, Anisuzzaman AS, Semba S, Ma Y, Uwada J, Hayashi H, Suzuki Y, Ikeuchi H, Uchino M, Maemoto A, Muramatsu I, Taniguchi T.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1842 Pages: 635-645
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460378
[Journal Article] Activation of focal adhesion kinase via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial injury2014
- Author(s)
  Md Rafiqul Islam Khan, Takashi Yazawa, Abu Syed Md Anisuzzaman, Shingo Semba, Yanju Ma, Junsuke Uwada, Hisayoshi Hayashi, Yuichi Suzuki, Hiroki Ikeuchi, Motoi Uchino, Atsuo Maemoto, Ikunobu Muramatsu, Takanobu Taniguchi
- Journal Title
  
  BBA Molecular Basis of Disease
  
  Volume: 1842 Issue: 4 Pages: 635-645
- DOI
  10.1016/j.bbadis.2013.12.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460378
[Journal Article] M1 ia a major subtype of muscarinic acetylcholine receptors on mouse colonic epitjelial cells2013
- Author(s)
  Khan MR, Anisuzzaman AS, Semba S, Ma Y, Uwada J, Hayashi H, Suzuki Y, Takano T, Ikeuti H, Uchino M, Ushikubi F, Muramatsu I, Taniguchi T
- Journal Title
  
  J Gastroenterol
  
  Volume: in press Issue: 8 Pages: 885-896
- DOI
  10.1007/s00535-012-0718-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24600006, KAKENHI-PROJECT-25460378
[Journal Article] Recent advances in technologies to analyze protein kinases.2006
- Author(s)
  Ishida, A, Kameshita, I., Sueyoshi, N., Taniguchi, T., Shigeri Y.
- Journal Title
  
  J Pharmacol Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590261
[Journal Article] Recent advances in technologies to analyze protein kinases.2006
- Author(s)
  Ishida, A, Kameshita, I., Sueyoshi, N., Taniguchi, T., Shigeri Y.
- Journal Title
  
  J Pharmacol Sci. (inpress)
- Data Source
  KAKENHI-PROJECT-17590261
[Journal Article] Characteristics of acid extrusion from Chinese hamster ovary cells expressed different prostaglandin EP receptors.2006
- Author(s)
  Okada, Y., Taniguchi T, Morishima, S., Suzuki, F., Akagi, Y., Muramatsu, I.
- Journal Title
  
  Life Sci 78
  
  Pages: 2454-2462
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590261
[Journal Article] Recent advances in technologies to analyze protein kinases.2006
- Author(s)
  Ishida, A, Kameshita, I., Sueyoshi, N., Taniguchi, T., Shigeri Y.
- Journal Title
  
  J Pharmacol Sci. (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590261
[Journal Article] Characteristics of acid extrusion from Chinese hamster ovary cells expressed different prostaglandin EP receptors.2006
- Author(s)
  Okada, Y., Taniguchi T, Morishima, S., Suzuki, F., Akagi, Y.Muramatsu, I.
- Journal Title
  
  Life Sci 78
  
  Pages: 2454-2462
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590261
[Journal Article] Identification of major Ca(2+)/calmodulin-dependent protein kinase phosphatase-binding proteins in brain : biochemical analysis of the interaction.2005
- Author(s)
  Ishida, A., Tada, Y., Nimura, T., Sueyoshi, N., Katoh, T., Takeuchi, M., Fujisawa, H., Taniguchi T, Kameshita, I.
- Journal Title
  
  Arch Biochem Biophys 435
  
  Pages: 134-146
- NAID
  120003132260
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590261
[Journal Article] Generation and application of a monoclonal antibody that detects a wide variety of protein tyrosine kinases.2005
- Author(s)
  Sugiyama Y, Sueyoshi N, Shigeri Y, Tatsu Y, Yumoto N, Ishida A, Taniguchi T, Kameshita I.
- Journal Title
  
  Anal Biochem 347
  
  Pages: 112-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590261
[Journal Article] Generation and application of a monoclonal antibody that detects a wide variety of protein tyrosine kinases.2005
- Author(s)
  Sugiyama Y, Sueyoshi N, Shigeri Y, Tatsu Y, Yumoto N, Ishida A, Taniguchi T, Kameshita I
- Journal Title
  
  Anal Biochem. 347
  
  Pages: 112-120
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590261
[Journal Article] Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.2005
- Author(s)
  Takayama, K., Yuhki, K., Ono, K., Fujino, T., Hara, A., Yamada, T., Kuriyama, S., Karibe, H., Okada, Y., Takahata, O., Taniguchi T, Iijima, T., Iwasaki, H., Narumiya, S., Ushikubi, F.
- Journal Title
  
  Nat Med 11
  
  Pages: 562-6
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590261
[Journal Article] Characteristics of acid extrusion from Chinese hamster ovary cells expressed different prostaglandin EP receptors.2005
- Author(s)
  Okada, Y., Taniguchi T, Morishima, S., Suzuki, F., Akagi, Y., Muramatsu, I.
- Journal Title
  
  Life Sci (in press)
- Data Source
  KAKENHI-PROJECT-17590261
[Journal Article] Generation and application of a monoclonal antibody that detects a wide variety of protein tyrosine kinases.2005
- Author(s)
  Sugiyama Y, Sueyoshi N, Shigeri Y, Tatsu Y, Yumoto N, Ishida A, Taniguchi T, Kameshita I.
- Journal Title
  
  Anal Biochem. 347
  
  Pages: 112-120
- Data Source
  KAKENHI-PROJECT-17590261
[Journal Article] Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia.2005
- Author(s)
  Takayama, K., Yuhki, K., Ono, K., Fujino, T., Hara, A., Yamada, T., Kuriyama, S., Karibe, H., Okada, Y., Takahata, O., Taniguchi T., Iijima, T., Iwasaki, H., Narumiya, S., Ushikubi, F.
- Journal Title
  
  Nat Med 11
  
  Pages: 562-566
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590261
[Patent] 抗チロシンキナーゼ抗体およびその利用2005
- Inventor(s)
  石田敦彦, 谷口隆信他
- Industrial Property Rights Holder
  香川大学産総研, 旭川医大
- Industrial Property Number
  2005-190494
- Filing Date
  2005-06-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590261
[Patent] 抗チロシンキナーゼ抗体およびその利用2005
- Inventor(s)
  石田敦彦, 谷口隆信, 他
- Industrial Property Rights Holder
  香川大学, 産総研, 旭川医大
- Industrial Property Number
  2005-190494
- Filing Date
  2005-06-29
- Data Source
  KAKENHI-PROJECT-17590261
[Presentation] Effect of probenecid on 3D-cultured prostate cancer spheroids2020
- Author(s)
  宇和田淳介, 矢澤隆志, 向井尚一郎, 寺田直樹, 谷口隆信
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06946
[Presentation] Analysis of testicular prostaglandin production and transcriptional regulation of COX-22019
- Author(s)
  矢澤隆志,今道力敬,宇和田淳介,谷口隆信
- Organizer
  日本生化学大会
- Data Source
  KAKENHI-PROJECT-18K06946
[Presentation] Muscarinic acetylcholine receptor regulates p38 MAPK through store-operated calcium entry in intestinal epithelial cells.2018
- Author(s)
  宇和田淳介,矢澤隆志,谷口隆信
- Organizer
  日本生化学大会
- Data Source
  KAKENHI-PROJECT-18K06946
[Presentation] Analysis of steroidogenic pathway using stem cell-derived steroidogenic cells.2018
- Author(s)
  宇和田淳介,矢澤隆志,谷口隆信
- Organizer
  日本生化学大会
- Data Source
  KAKENHI-PROJECT-18K06946
[Presentation] 幹細胞からのステロイドホルモン産生細胞の分化誘導2017
- Author(s)
  矢澤隆志、今道力敬、宮本薫、宇和田淳介、谷口隆信
- Organizer
  第90回　日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15K10654
[Presentation] ライディッヒ細胞におけるEP受容体を介したステロイドホルモン産生調節機構2017
- Author(s)
  矢澤隆志、今道力敬、宮本薫、宇和田淳介、谷口隆信
- Organizer
  第90回　日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K10654
[Presentation] 哺乳類における11-ケトテストステロン産生2017
- Author(s)
  矢澤隆志、今道力敬、宮本薫、宇和田淳介、谷口隆信
- Organizer
  第88回　日本動物学会富山大会
- Data Source
  KAKENHI-PROJECT-15K10654
[Presentation] （原文）：精巣・ライディッヒ細胞におけるCox-2の発現とステロイドホルモン産生制御2016
- Author(s)
  矢澤隆志、今道力敬、宇和田淳介、谷口隆信
- Organizer
  第８９回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K10654
[Presentation] Novel androgen metabolic pathway in human gonads2016
- Author(s)
  Yazawa T, Imamichi Y, Uwada J, Taniguchi T
- Organizer
  第２２回国際動物学会
- Place of Presentation
  Okinawa
- Year and Date
  2016-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10654
[Presentation] ライディッヒ細胞におけるプロスタグランジン産生とその機能2015
- Author(s)
  矢澤隆志、今道力敬、宮本薫、谷口隆信
- Organizer
  日本動物学会第86回新潟大会
- Place of Presentation
  新潟
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-15K10654
[Presentation] Activation of FAK via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial injury.2015
- Author(s)
  Islam T, Khan MRI, Yazawa T, Taniguchi T.
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25460378
[Presentation] ライディッヒ細胞におけるCox-2発現制御とプロスタグランジン産生2015
- Author(s)
  矢澤隆志、今道力敬、宮本薫、谷口隆信
- Organizer
  第８８回日本内分泌学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K10654
[Presentation] TJ構成因子FAKは、ムスカリンM1受容体シグナルを介した腸上皮バリア機能維持や修復の標的となる2015
- Author(s)
  矢澤隆志、宇和田淳介、イスラムタリクル、谷口隆信
- Organizer
  第112回北海道癌談話会例会
- Place of Presentation
  札幌
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K10654
[Presentation] Activation of FAK via M1 muscarinic acetylcholine receptor is required in restitution of intestinal barrier function after epithelial injury2014
- Author(s)
  イスラムタリクル, カーンロフィクルイスラム, 矢澤隆志, 谷口隆信
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-25460378

1. KATOH Tsuyoshi (60194833)

# of Collaborated Projects: 8 results

# of Collaborated Products: 1 results
2. MURAMATSU Ikunobu (10111965)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
3. YAMAMURA Hirohei (90030882)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. YAZAWA Takashi (00334813)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
5. TAKEUCHI Masayuki (40226999)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
6. UWADA Junsuke (70580314)

# of Collaborated Projects: 5 results

# of Collaborated Products: 23 results
7. TANAKA Yukie (10197486)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. NAKAMURA Shunーichi (40155833)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. HASHIMOTO Eikichi (20116239)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. SUZUKI Fumiko (80291376)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. ISHIDA Atsuhiko (90212886)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
12. MARUYAMA Shingo (90262633)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. YANAGI Shigeru (60252003)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. INAZU Tetsuya (00242587)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. ZHU Jun (90303370)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. YAMAMOTO Tadashi (40134621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SADA Kiyonao (10273765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. MINAMI Yasuhiro (70229772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. OKADA Kenichiro (60026838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TANAKA Takashi (40313746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SHIGERI Yasushi (90357187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KAMESHITA Isamu (60127941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 竹内郁登 (70262623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 益岡尚由 (80509307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. KUROSAKI Tomohiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KINET Jean-pierre

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. TOMOHIRO Kur

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. TAKAHASHI Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. IWANO Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. KASUNO Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 鈴木信雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
32. 関口俊男

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
33. 岡田令子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 向井邦晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TANIGUCHI Takanobu 谷口 隆信

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Reinforcement of colonic epithelial barrier via mAChRPrincipal Investigator

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Maintenance of intestinal barrier function by focal adhesion kinasePrincipal Investigator

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Analysis of Signal Transduction Pathway of Syk in Breast Cancer Cells-as a comparison with that of Her2Principal Investigator

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Role of endothelin in the physiological closure of Ductus ArtenosusPrincipal Investigator

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Effect of nicotine administration on development of muscarinic receptor in central nervous system of rat neonatePrincipal Investigator

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Relaxation of IGF2 and KIP2 imprinting in Wilms tumours and other urogenital tumoursPrincipal Investigator

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TANIGUCHI Takanobu 谷口隆信