Fujita Ken-ichi 藤田健一

… Alternative Names

FUJITA Keniti 藤田健一

FUJITA Ken-ichi 藤田健一

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Researcher Number	60281820
Other IDs
Affiliation (Current)	2025: 昭和医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 昭和大学, 薬学部, 教授 2017: 昭和大学, 大学共同利用機関等の部局等, 教授 2015 – 2016: 昭和大学, 腫瘍分子生物学研究所, 教授 2013 – 2014: 昭和大学, 腫瘍分子生物学研究所, 准教授 2010 – 2013: 埼玉医科大学, 医学部, 講師 … More 2007 – 2008: Saitama Medical University, 医学部, 助教 1998 – 2001: Fac.of Pharm.Sci., Hokkaido Univ., Instructor, 大学院・薬学研究科, 助手 1998: 北海道大学, 大学院薬学研究科, 助手 1996 – 1997: 北海道大学, 薬学部, 教務職員 Less
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy / Environmental pharmacy / Applied pharmacology Except Principal Investigator Biological pharmacy / Applied pharmacology / 応用薬理学・医療系薬学 / Environmental pharmacy / Pathological medical chemistry
Keywords	Principal Investigator 体内動態 / 遺伝子多型 / 副作用 / 遊離形血漿中濃度 / COX / P450 / イリノテカン / 蛋白結合 / 肝消失型抗がん薬 / 尿毒素 … More / SN-38 / 薬物動態 / 血漿中蛋白結合 / メタボロミクス / メタボロミクス解析 / エクソーム解析 / 効果 / 肝細胞がん / レンバチニブ / 活性代謝物 / 治療中止 / 相対治療強度 / 活性代謝物M-5 / 活性代謝物M-2 / 脂質メタボロミックス / HLA遺伝子 / グレード3 / VEGFR-2 / ハプロタイプ / マウス / ケラチノサイト / VFGF-A / 手足症候群 / HLA / 多形紅斑 / ABCG2 / AUC / 治療強度 / 無増悪生存期間 / レゴラフェニブ / teratogenicity / animal model / humanized mice / transgenic mice / thalidomide / fetal toxicity / チトクロームP450 / フェニトイン / アフラトキシンB_1 / H合成酵素 / プロスタグランジンG / 催奇形性 / 実験動物 / ヒト化マウス / トランスジェニックマウス / サリドマイド / 胎児毒性 / 遊離形 / イリノテカン塩酸塩 / long-lasting inhibition / indole / 肝代謝型 / 投与設計 / PBPKモデル / 腎機能障害 / UGT1A1 / トランスポーター / 腎不全 / 尿毒症物質 / 腎機能 / 排出遅延 / 肝消失型 / 発現低下 / OATP1B1 / 腎機能低下 / 排泄遅延 / 薬力 / 緩和医療 / がん疼痛 / UGT2B7 / OPRM1 / ABCB1 / 薬物有害反応 / 薬理遺伝学 / モルヒネ … More Except Principal Investigator P450 / チトクロームP450 / 遺伝子多型 / CYP3A7 / poor metabolizer / 代謝的活性化 / CYP2D6 / CYP3A4 / 薬物代謝 / CYP2A6 / トランスジェニックマウス / 発現系 / CGH / COX-2 / EBPα / C / p53 / 薬物間相互作用 / 薬物相互作用 / gene analysis / genetic polymorphism / 遺伝子解析 / 遺伝的多型 / FMO / population study / polymorphism / SM-12502 / Metabolic activation / CYP1A2 / サルモネラ菌 / 遺伝子治療 / 代謝欠損 / クローニング / トリメチルアミン / ノックアウトマウス / 遺伝病 / 薬物動態学 / 代謝物 / 薬剤応答性 / 体内動態 / ファーマコメタボロミクス / 内在性バイオマーカー / ファーマコメタボローム / 一塩基多型 / 個体間変動 / 薬物トランスポーター / 内在性基質 / バイオマーカー / microsatellite instability / genomic instability / intrahepatic cholangiocarcinoma / xanthogranulomatous cholecystitis / gall bladder cancer / biliary tract cancer / 黄色肉芽腫瘍胆襄炎 / がん遺伝子 / 症例・対照研究 / 薬剤代謝酵素 / ミクロサテライト不安定性 / マイクロサテライト不安定性 / ゲノム不安定性 / 肝内胆管がん / 黄色肉芽腫様胆嚢炎 / 胆嚢がん / 胆道がん / transgenic mouse / gene regulation / development / fetal toxicity / 時期特異的発現調節 / 個人差 / 発現調節 / ヒト肝 / CYP3A5 / 胎児 / 転写制御 / 発生 / 胎児毒性 / Xenobiotic-responsive element / receptor / Aryl hydrocarbon / DNAのメチル化 / 異物応答配列 / 芳香族炭化水素受容体 / DRUG DEVELOPMENT / RECOMBINANT / DRUG INTERACTION / DRUG METANBOISM / INHIBITION / PLATE READER / HIGH THROUGH PUT / 水溶性ポリマー / チトクロームb_5 / 大腸菌発現系 / ハイスループットシステム / 医薬品開発 / 遺伝子組換え / 阻害 / プレートリーダー / ハイスループット / CYP2D6^36 / Adverse reaction / cytochrome P450 / drug metabolism / フレームシフト型変異 / CYP2D6^10C / 遺伝的解析 / 薬の効き過ぎ / CYP2D636 / 薬の効きすぎ / human genome / heterologous expression / gene therapy / genetic disease / trimethylamine / ヒトゲノム / 異種細胞発現系 / DNA damage / Aflatoxin B1 / Fetus-specific / Cytochrome P450 / HITEC mouse / Mutagenicity testing / アフラトキシンB_1 / 突然変異検出系 / アフラトキシンB1 / 胎児特異的 / HITECマウス / coumarin / genotyping / 発がん / drugmetabolism / チトクロームP450 2A6 / チトクロームP450 2D6 / poor mtabolizer / クマリン / 遺伝子診断 / Lung cancer / Genetic polymorphism / Mutation assay / Salmonella typhimurium / P450アロマターゼ / がん原物質活性化 / 遺伝子導入マウス / Ahレセプター / アロマターゼ / CYP1A1 / 発現制御 / DNAアダクト / がん原物質 / 肺がん / 変異原性試験 / 人種差 / VKORC12 / CYP2C98 / CYP2C93 / INR / VKORC1 / CYP2C9 / 応答性 / 個体差 / ワルファリン / ファーマコゲノミクス / ABCC2 / UGTIA1 / 用量調節試験 / 塩酸イリノテカン / 副作用 / 大腸癌 / 個別化医療 / 薬物動態 / UGT1A1 / イリノテカン / ゲノム薬理学 / 臨床薬理学 / ヒト組織利用研究 / 寿命制御遺伝子 / 遺伝子欠損型多型 / ニコチン / 肺がんリスク / 煙草 / ニトロソアミン / ヒト型マウス / タバコ / がん Less

肝がん患者でのアルブミン低下と治療薬レンバチニブの遊離形体内動態・薬物応答の関連Principal Investigator
- Principal Investigator
  
  藤田健一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa University
Clinical impact of unbound-base pharmacokinetics of active metabolites of a tyrosine kinase inhibitor regorafenibPrincipal Investigator
- Principal Investigator
  
  Fujita Ken-ichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa University
Exploration study to identify pharmacokinetic biomarkers by pharmacometabolomic approaches
- Principal Investigator
  
  Kusuhara Hiroyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  The University of Tokyo
Mechanisms of delayed elimination and decreased plasma protein binding of anticancer drugs which are mainly eliminated via the liver in cancer patients with severe renal failurePrincipal Investigator
- Principal Investigator
  
  Fujita Ken-ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa University
Mechanism for the delayed elimination of SN-38 in cancer patients with severe renal failure and optimal treatment strategyPrincipal Investigator
- Principal Investigator
  
  FUJITA Ken-ichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa University
  Saitama Medical University
Association of pharmacokinetics or pharmacogenomics with toxicity of erlotinib in patients with advanced non-small cell lung cancer
- Principal Investigator
  
  HIROSE Takashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tokyo National Hospital (Clinical research)
  Showa University
Establishment of pharmacogenetic-based dosing algorithm of warfarin for Asian, Caucasian and African American patients
- Principal Investigator
  
  TAKAHASHI Harumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Meiji Pharmaceutical University
Phase I/II study of irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI) in Japanese patients with advanced colorectal cancer and genetic testing for UDP-glucuronosyltransferase (UGT) 1A1*28 and *6.
- Principal Investigator
  
  NAGASHIMA Fumio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Saitama Medical University
Factors causing interindividual variability in response to morphinePrincipal Investigator
- Principal Investigator
  
  FUJITA Ken-ichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Saitama Medical University
In vivo model to predict human fetal toxicity of xenobiotics : Establishment and evaluation of humanized mice carrying multiple forms of human fetal drug metabolizing enzymes.Principal Investigator
- Principal Investigator
  
  KAMATAKI Tetsuya, 藤田健一
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
CYP2A6のpharmacogenomics的研究
- Principal Investigator
  
  鎌滝哲也
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokkaido University
Transcriptional regulation of the CYP3A7 gene specifically expressed in the human fetal liver.
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Genetic oncological and molecular epidemiological research on development and progression of the biliary tract cancer in Asia
- Principal Investigator
  
  MIWA Masanao
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  University of Tsukuba
Metabolic activation of procarcinogens and cancer risk
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
ANALYSIS OF GENE MUTATION IN THAI CAUSING FISH ODOR SYNDROME
- Principal Investigator
  
  KAMATAKL Tetsuya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Developmental study for effective high-through-put screening system for new drug registration
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY
Molecular mechanism (s) responsible for species difference in dioxin toxicity
- Principal Investigator
  
  TAKAHASHI Yoshiki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokkaido University
GENETIC POLYMORPHISM OF DRUG METABOLIZING-ENZYME ; ANALYSIS OF NOVEL POLYMORPHISM AND DEVELOPMENT OF GENOTYPING METHOD
- Principal Investigator
  
  ARIYOSHI Noritaka
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HOKKAIDO UNIVERSITY
魚臭症候群の原因となるフラビン含有モノオキシゲナーゼ遺伝子の解析
- Principal Investigator
  
  KAMATAKI Tetsuya
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
APPLICATION OF TRANSGENIC MICE TO THE TOXICOLOGICAL TESTING
- Principal Investigator
  
  NAKAYAMA Kazuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HOKKAIDO UNIVERSITY
Pharmacogenetics of drug metabolizing enzymes
- Principal Investigator
  
  YOKOI Tsuyoshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  HOKKAIDO UNIVERSITY

[Journal Article] Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice.2023
- Author(s)
  Al-Shammari AH, Masuo Y, Yoshino S, Yamashita R, Ishimoto T, Fujita K, Kato Y.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 49 Pages: 100483-100483
- DOI
  10.1016/j.dmpk.2022.100483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06688, KAKENHI-PROJECT-19K07204, KAKENHI-PROJECT-23K24044, KAKENHI-PROJECT-20K15991
[Journal Article] Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition2022
- Author(s)
  Hasan Alshammari A, Masuo Y, Fujita KI, Shimada K, Iida N, Wakayama T, Kato Y
- Journal Title
  
  Biochamical Pharmacology
  
  Volume: 印刷中 Pages: 114914-114914
- DOI
  10.1016/j.bcp.2022.114914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07204, KAKENHI-PROJECT-21K06688
[Journal Article] Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients With Non-Small Cell Lung Cancer Treated With Paclitaxel2020
- Author(s)
  Mori D, Ishida H, Mizuno T, Kusumoto S, Kondo Y, Izumi S, Nakata G, Nozaki Y, Maeda K, Sasaki Y, Fujita KI, Kusuhara H.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 48 Issue: 5 Pages: 387-394
- DOI
  10.1124/dmd.119.089474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04100
[Journal Article] Higher Systemic Exposure to Unbound Active Metabolites of Regorafenib Is Associated With Short Progression-Free Survival in Colorectal Cancer Patients.2020
- Author(s)
  Kubota Y, Fujita KI, Takahashi T, Sunakawa Y, Ishida H, Hamada K, Ichikawa W, Tsunoda T, Shimada K, Masuo Y, Kato Y, Sasaki Y.
- Journal Title
  
  Clin Pharmacol Ther
  
  Volume: - Issue: 3 Pages: 586-595
- DOI
  10.1002/cpt.1810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06745, KAKENHI-PROJECT-19K07204, KAKENHI-PROJECT-18H02584
[Journal Article] Increased plasma concentrations of unbound SN-38, the active metabolite of irinotecan, in cancer patients with severe renal failure2016
- Author(s)
  Ken-ichi Fujita, Yusuke Masuo, Hidenori Okumura, Yusuke Watanabe, Hiromichi Suzuki, Yu Sunakawa, Ken Shimada, Kaori Kawara, Yuko Akiyama, Masanori Kitamura, Munetaka Kunishima, Yasutsuna Sasaki, Yukio Kato
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 33 Issue: 2 Pages: 269-282
- DOI
  10.1007/s11095-015-1785-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460205, KAKENHI-PROJECT-15H04664, KAKENHI-PROJECT-26860099
[Journal Article] 透析を要するほど腎機能の低下したがん患者における肝消失型抗がん薬イリノテカン塩酸塩の特異な体内動態と毒性2015
- Author(s)
  藤田健一
- Journal Title
  
  日本透析医会雑誌
  
  Volume: 30 Pages: 538-542
- Data Source
  KAKENHI-PROJECT-26460205
[Journal Article] 腎機能障害患者における肝消失型抗がん薬の特異な体内動態について2014
- Author(s)
  藤田健一
- Journal Title
  
  ファルマシア
  
  Volume: 50 Pages: 300-304
- NAID
  130005154888
- Data Source
  KAKENHI-PROJECT-23590198
[Journal Article] Optimization of cancer chemotherapy on the basis of pharmacokinetics and pharmacodynamics : from patients enrolled in clinical trials to those in the 'real world'2014
- Author(s)
  Fujita K, Sasaki Y
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 29 Pages: 20-8
- NAID
  130004463350
- URL
  https://www.jstage.jst.go.jp/browse/dmpk/29/0/_contents
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590198
[Journal Article] Optimization of cancer chemotherapy on the basis of pharmacokinetics and pharmacodynamics: from patients enrolled in ‘clinical trials’ to those in the ‘real world’2014
- Author(s)
  Ken-ichi Fujita, Yasutsuna Sasaki
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 29 Pages: 20-28
- NAID
  130004463350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590198
[Journal Article] 腎機能障害患者における肝消失型抗がん薬の特異な体内動態について2014
- Author(s)
  藤田健一
- Journal Title
  
  ファルマシア「最前線」
  
  Volume: 50 Pages: 300-304
- NAID
  130005154888
- URL
  http://farumashia.pharm.or.jp/mokuji/mokuji.html
- Data Source
  KAKENHI-PROJECT-23590198
[Journal Article] Direct inhibition and down-regulation by uremic plasma components of hepatic uptake transporter for SN-38, an active metabolite of irinotecan, in humans2014
- Author(s)
  Fujita K, Sasaki Y, Kato Y(他9名)
- Journal Title
  
  Pharm Res
  
  Volume: 31 Issue: 1 Pages: 204-15
- DOI
  10.1007/s11095-013-1153-x
- NAID
  120005385991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590198, KAKENHI-PROJECT-24390040, KAKENHI-PROJECT-25460092
[Journal Article] 腎機能障害がん患者における塩酸イリノテカンの特異な体内動態，シスプラチンによる腎機能障害のメカニズム2013
- Author(s)
  藤田健一
- Journal Title
  
  月刊薬事(The Pharmaceuticals Monthly)
  
  Volume: 55 Pages: 49-54
- Data Source
  KAKENHI-PROJECT-23590198
[Journal Article] 腎機能障害がん患者におけるイリノテカン塩酸塩の特異な体内動態2013
- Author(s)
  藤田健一
- Journal Title
  
  シスプラチンによる腎機能障害のメカニズム月刊薬事
  
  Volume: 55 Pages: 49-54
- URL
  http://www.jiho.co.jp/tabid/162/Default.aspx
- Data Source
  KAKENHI-PROJECT-23590198
[Journal Article] Delayed elimination of SN-38 in cancer patients with severe renal failure.2011
- Author(s)
  Fujita Ken-ichi
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 31 Pages: 161-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590546
[Journal Article] Phase I/II study of FOLFIRI in Japanese patients with advanced colorectal cancer.2011
- Author(s)
  Yamashita K, Nagashima F, Fujita K, Yamamoto W, Endo H, Miya T, Narabayashi M, Kawara K, Akiyama Y, Ando Y, Ando M, Sasaki Y.
- Journal Title
  
  Jpn J Clin Oncol 41
  
  Pages: 204-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590546
[Journal Article] UGT1A1*1/*28 and *1/*6 genotypes have no effects on the efficacy and toxicity of FOLFIRI in Japanese patients with advanced colorectal cancer.2010
- Author(s)
  Sunakawa Y, Ichikawa W, Fujita KI, Nagashima F, Ishida H, Yamashita K, Mizuno K, Miwa K, Kawara K, Akiyama Y, Araki K, Yamamoto W, Miya T, Narabayashi M, Ando Y, Hirose T, Saji S, Sasaki Y.
- Journal Title
  
  Cancer Chemother Pharmacol in press
- Data Source
  KAKENHI-PROJECT-20590546
[Journal Article] Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer2009
- Author(s)
  FujitaKen-ichi、Ando Yuichi、Yamamoto Wataru、Miya Toshimichi、Endo Hisashi、Sunakawa Yu、Araki Kazuhiro、Kodama Keiji、Nagashima Fumio、Ichikawa Wataru、 Narabayashi Masaru 、Akiyama Yuko 、Kawara Kaori 、Shiomi Mari 、Ogata Hiroyasu 、Iwasa Hiroyasu 、Okazaki Yasushi 、Hirose Takashi 、Sasaki Yasutsuna
- Journal Title
  
  Cancer Chemotherapy and Pharmacology in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590542
[Journal Article] モルヒネの薬効・有害反応を規定する因子を解明するための臨床研究2008
- Author(s)
  藤田健一
- Journal Title
  
  臨床薬理の進歩 29
  
  Pages: 168-173
- Data Source
  KAKENHI-PROJECT-19590542
[Journal Article] モルヒネの薬効と有害反応を規定する因子を解明するための臨床研究2008
- Author(s)
  藤田健一
- Journal Title
  
  臨床薬理の進歩 (In press)
- Data Source
  KAKENHI-PROJECT-19590542
[Journal Article] Association of ATP-binding cassette, sub-family C, number 2 (ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI).2008
- Author(s)
  Fujita K, Nagashima F, Yamamoto W, Endo H, Sunakawa Y, Yamashita K, Ishida H, Mizuno K, Matsunaga M, Araki K, Tanaka R, Ichikawa W, Miya T, Narabayashi M, Akiyama Y, Kawara K, Ando Y, Sasaki Y.
- Journal Title
  
  Biol Pharm Bull 31
  
  Pages: 2137-2142
- NAID
  110006968101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590546
[Journal Article] Association of ATP-binding cassette, sub-family C, number 2(ABCC2) genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with irinotecan plus infusional 5-fluorouracil/leucovorin (FOLFIRI).2008
- Author(s)
  藤田健一
- Journal Title
  
  Biol Pharm Bull. 31
  
  Pages: 2137-2142
- NAID
  110006968101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590546
[Journal Article] Genetic testing for UGT1A1*28 and *6 in Japanese patients who receive irinotecan chemotherapy.2008
- Author(s)
  Akiyama Y, Fujita K, Nagashima F, Yamamoto W, Endo H, Sunakawa Y, Yamashita K, Ishida H, Mizuno K, Araki K, Ichikawa W, Miya T, Narabayashi M, Kawara K, Sugiyama M, Hirose T, Ando Y, Sasaki Y.
- Journal Title
  
  Ann Oncol 19
  
  Pages: 2089-2090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590546
[Presentation] Associations of polymorphisms in CCL4L1 with regorafenib-induced hand-foot skin reaction in colorectal cancer patients.2023
- Author(s)
  Koutaro Ono, Remi Murase, Natsumi Matsumoto, Yutaro Kubota, Hiroo Ishida, Takuya Tsunoda, Yasutsuna Sasaki, Ken-ichi Fujita
- Organizer
  The 20th Japanese Society of Medical Oncology annual meeting
- Data Source
  KAKENHI-PROJECT-19K07204
[Presentation] レンバチニブ投与患者血漿検体のメタボロミクス解析による薬効バイオマーカー探索2022
- Author(s)
  水戸守智香、増尾友佑、荒井潤、松本奈都美、鈴木康介、吉田仁、藤田健一、加藤将夫
- Organizer
  日本臨床薬理学会
- Data Source
  KAKENHI-PROJECT-22K06732
[Presentation] Investigation of the role of hepatic Bcrp by using adeno-associated virus mediated gene knockdown.2022
- Author(s)
  Shotaro Yoshino, Yusuke Masuo, Reiya Yamashita, Ken-ichi Fujita, Yukio Kato
- Organizer
  37th Japanese Society for the Study of Xenobiotics annual meeting
- Data Source
  KAKENHI-PROJECT-19K07204
[Presentation] Associations of HLA-C*01:02 and HLA-B*46:01 with regorafenib-induced erythema multiforme in Japanese patients with colorectal cancer2022
- Author(s)
  Kosuke Takeshima, Natsumi Matsumoto, Yutaro Kubota, Hiroo Ishida, Takuya Tsunoda, Yasutsuna Sasaki, Ken-ichi Fujita
- Organizer
  123rd American Society for Clinical Pharmacology and Therapeutics annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07204
[Presentation] Regorafenib-induced erythema multiforme is associated with HLA-C*01:02 and HLA-B*46:01 in Japanese cancer patients2021
- Author(s)
  Natsumi Matsumoto, Kosuke Takeshima, Yutaro Kubota, Hiroo Ishida, Takuya Taunoda, Yasutsuna Sasaki, Ken-ichi Fujita
- Organizer
  The 19th Japanese Society of Medical Oncology annual meeting
- Data Source
  KAKENHI-PROJECT-19K07204
[Presentation] Plasma concentration changes of endogenous OATP1B1 substrates before and after paclitaxel administration in non-small cell lung cancer2020
- Author(s)
  Hiroyuki Kusuhara, Daiki Mori, Hiroo Ishida, Tadahaya Mizuno, Yusuke Kondo, Genki Nakada, Kazuya Maeda, Ken-Ichi Fujita
- Organizer
  PSWC2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] High unbound plasma concentration of M-2, an active metabolite, is associated with shorter survival in patients with metastatic colorectal cancer who received regorafenib2019
- Author(s)
  Yutaro Kubota, Ken-ichi Fujita, Takehiro Takahashi, Yu Sunakawa, Hiroo Ishida, Kazuyuki Hamada, Wataru Ichikawa, Takuya Tsunoda, Yusuke Masuo, Yukio Kato, Yasutsuna Sasaki
- Organizer
  110th American Association for Cancer Research annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07204
[Presentation] Evaluation of endogenous biomarkers of OATP1B activity in patients with non-small cell lung cancer who received paclitaxel2019
- Author(s)
  Hiroyuki Kusuhara, Daiki Mori, Hiroo Ishida, Tadahaya Mizuno, Ken-ichi Fujita, Sojiro Kusumoto, Kazuya Maeda, Yasutsuna Sasaki
- Organizer
  ISSX2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 内因性基質をプローブとしたパクリタキセルによるOATP1Bを介した薬物相互作用リスク評価2018
- Author(s)
  森大輝、石田博雄、水野忠快、藤田健一、楠本壮二郎、前田和哉、佐々木康綱、楠原洋之
- Organizer
  第13回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] トランスポーター介在性薬物相互作用リスク評価への内在性バイオマーカーの適用2018
- Author(s)
  森大輝, 石田博雄, 水野忠快, 藤田健一, 楠本壮二郎, 前田和哉, 佐々木康綱, 楠原洋之
- Organizer
  第4回　次世代を担う若手のためのレギュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] Assessment of drug-drug interaction potency against OATP1B with paclitaxel using an endogenous substrate as an alternative probe2017
- Author(s)
  Daiki Mori, Hiroo Ishida, Tadahaya Mizuno, Ken-ichi Fujita, Sojiro Kusumoto, Kazuya Maeda, Yasutsuna Sasaki, Hiroyuki Kusuhara
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] 内在性基質をプローブとした抗がん剤パクリタキセルによるOATP1B阻害の検出2017
- Author(s)
  森大輝、石田博雄、水野忠快、藤田健一、前田和哉、佐々木康綱、楠原洋之
- Organizer
  第38回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04100
[Presentation] レゴラフェニブと活性代謝物の体内動態解析とABC輸送担体の関与2016
- Author(s)
  藤田健一，増尾友佑，山崎絵里名，澁谷俊紀，中道範高，佐々木康綱，加藤将夫
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  米子
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Unfit症例におけるがん薬物療法の至適化と臨床薬理学：腎障害患者におけるイリノテカンの特異な体内動態と投与法（シンポジウム）2016
- Author(s)
  藤田健一
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  米子
- Year and Date
  2016-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Delayed elimination of SN-38 in cancer patients with severe renal failure: mechanism and appropriate irinotecan dose2016
- Author(s)
  Ken-ichi Fujita
- Organizer
  The 13th Japanese Society of Medical Oncology annual meeting
- Place of Presentation
  Kobe
- Year and Date
  2016-07-28
- Invited
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] 腎機能低下がん患者における特異なSN-38の体内動態とPBPKモデル2016
- Author(s)
  藤田健一
- Organizer
  医療薬学フォーラム2016/第24回クリニカルファーマシーシンポジウム
- Place of Presentation
  大津
- Year and Date
  2016-06-25
- Invited
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Involvement of ABC drug transporters in disposition of active metabolites of tyrosine kinase inhibitor regorafenib2016
- Author(s)
  Erina Yamazaki, Yusuke Masuo, Ken-ichi Fujita, Toshiki Shibutani, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  31st Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Delayed elimination of SN-38 in cancer patients with severe renal failure: mechanism and appropriate irinotecan dose (Symposium)2016
- Author(s)
  Ken-ichi Fujita
- Organizer
  The 14th Japanese Society of Medical Oncology annual meeting
- Place of Presentation
  神戸
- Year and Date
  2016-07-28
- Invited
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] 腎機能低下がん患者における特異なSN-38の体内動態とPBPKモデル(シンポジウム)2016
- Author(s)
  藤田健一
- Organizer
  医療薬学フォーラム2016/第24回クリニカルファーマシーシンポジウム
- Place of Presentation
  大津
- Year and Date
  2016-06-25
- Invited
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Inhibition of human hepatic transporter OATP1B1 by indole metabolites2016
- Author(s)
  Natsumi Seba, Yusuke Masuo, Ken-ichi Fujita, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  31st Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] 極めて腎機能の低下したがん患者におけるイリノテカン塩酸塩の至適投与量の推定2015
- Author(s)
  藤田健一，増尾友祐，奥村英典，佐々木康綱，加藤将夫
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Appropriate dose of irinotecan in cancer patients with severe renal failure (SRF)2015
- Author(s)
  Ken-ichi Fujita, Yusuke Masuo, Hidenori Okumura, Yasutsuna Sasaki and Yukio Kato
- Organizer
  The 12nd Japanese Society of Medical Oncology annual meeting
- Place of Presentation
  Sapporo
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Long-lasting inhibition of organic anion transporting polypeptide (OATP) 1B1 by endogenous uremic toxin indoxyl sulfate2015
- Author(s)
  Tatsuya Kogi, Yusuke Masuo, Ken-ichi Fujita, Masanori Kitamura, Noritaka Nakamichi, Yasutsuna Sasaki, Munetaka Kunishima, Yukio Kato
- Organizer
  30th Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  Tokyo
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] 透析を実施中のがん患者における塩酸イリノテカンの至適投与に向けた臨床･基礎研究2014
- Author(s)
  藤田健一
- Organizer
  第47回制癌剤適応研究会
- Place of Presentation
  名古屋
- Invited
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] 透析を実施中のがん患者におけるイリノテカン塩酸塩の至適投与に向けた臨床・基礎研究2014
- Author(s)
  藤田健一
- Organizer
  第47回制癌剤適応研究会
- Place of Presentation
  名古屋 (シンポジウム)
- Year and Date
  2014-03-07
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] OATP1B1-mediated hepatic uptake of SN-38, an active metabolite of irinotecan, and its inhibition by uremic toxins in humans2013
- Author(s)
  Fujita K, Sugiura T, Okumura H, Umeda S, Nakamichi N, Sasaki Y, Kato Y
- Organizer
  114^<th> American Society for Clinical Pharmacology and Therapeutics annual meeting
- Place of Presentation
  Indianapolis
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Direct Inhibition and Down-regulation by Uremic Plasma Components of Hepatic Uptake Transporter for SN-38, an Active Metabolite of Irinotecan, in Humans2013
- Author(s)
  Hidenori Okumura, Ken-ichi Fujita, Yusuke Masuo, Tomoko Sugiura, Noritaka Nakamichi, Yusuke Watanabe, Hiromichi Suzuki, Yu Sunakawa, Ken Shimada, Kaori Kawara, Yasutsuna Sasaki, Yukio Kato
- Organizer
  28th Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Down-regulation by uremic plasma components of hepatic uptake transporter for SN-38 in humans2013
- Author(s)
  Ken-ichi Fujita, Noritaka Nakamichi, Yu Sunakawa, Ken Shimada, Kaori Kawara, Yasutsuna Sasaki, Yukio Kato
- Organizer
  72nd Japan Cancer Association meeting
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Direct Inhibition and Down-regulation by Uremic Plasma Components of Hepatic Uptake Transporter for SN-38, an Active Metabolite of Irinotecan, in Humans2013
- Author(s)
  Okumura H, Fujita K, Masuo Y, Sugiura T, Nakamichi N, Watanabe Y, Suzuki H, Sunakawa Y, Shimada K, Kawara K, Sasaki Y, Kato Y
- Organizer
  28^<th> Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Down-regulation by uremic plasma components of hepatic uptake transporter for SN-38 in humans2013
- Author(s)
  Fujita K, Nakamichi N, Sunakawa Y, Shimada K, Kawara K, Sasaki Y, Kato Y
- Organizer
  72^<nd> Japan Cancer Association meeting
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] 透析を施行中のがん患者における塩酸イリノテカンの至適投与に向けた臨床・基礎研究2013
- Author(s)
  藤田健一
- Organizer
  第34回日本臨床薬理学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] 透析を施行中のがん患者におけるイリノテカン塩酸塩の至適投与に向けた臨床・基礎研究2013
- Author(s)
  藤田健一
- Organizer
  第34回日本臨床薬理学会
- Place of Presentation
  東京 (シンポジウム)
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] OATP1B1-mediated hepatic uptake of SN-38, an active metabolite of irinotecan, and its inhibition by uremic toxins in humans2013
- Author(s)
  Ken-ichi Fujita, Tomoko Sugiura, Hidenori Okumura, Saki Umeda, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  114th American Society for Clinical Pharmacology and Therapeutics annual meeting
- Place of Presentation
  Indianapolis, USA
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Involvement of OATP and inhibition by uremic toxins in hepatic uptake of an anticancer agent SN-38 in humans2012
- Author(s)
  Tomoko Sugiura, Ken-ichi Fujita, Hidenori Okumura, Saki Umeda, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  27th Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Partial inhibition by uremic toxins of hepatic uptake of an active metabolites SN-38 of irinotecan in humans2012
- Author(s)
  Fujita K, Sugiura T, Nakamichi N, Akiyama Y, Sasaki Y, Kato Y
- Organizer
  71^<st> Japan Cancer Association meeting
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Partial inhibition by uremic toxins of hepatic uptake of an active metabolite SN-38 of irinotecan in humans2012
- Author(s)
  Fujita K, Sugiura T, Umeda S, Okumura H, Nakamichi N, Sasaki Y, Kato Y
- Organizer
  33^<rd> Annual meeting of the Japanese Society of Clinical Pharmacology and Therapeutics
- Place of Presentation
  Naha
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Partial inhibition by uremic toxins of hepatic uptake of an active metabolites SN-38 of irinotecan in humans2012
- Author(s)
  Ken-ichi Fujita, Tomoko Sugiura, Noritaka Nakamichi, Yuko Akiyama, Yasutsuna Sasaki, Yukio Kato
- Organizer
  71st Japan Cancer Association meeting
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Characterization of hepatic uptake mechanism for SN-38, an active metabolite of the anticancer agent irinotecan in humans2012
- Author(s)
  Fujita K, Sugiura T, Umeda S, Okumura H, Nakamichi N, Sasaki Y, Kato Y
- Organizer
  The 18^<th> International Society for the Study of Xenobiotics North American Regional meeting
- Place of Presentation
  Dallas
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Partial inhibition by uremic toxins of hepatic uptake of an active metabolite SN-38 of irinotecan in humans2012
- Author(s)
  Ken-ichi Fujita, Tomoko Sugiura, Saki Umeda, Hidenori Okumura, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  33rd Annual meeting of the Japanese Society of Clinical Pharmacology and Therapeutics
- Place of Presentation
  Naha
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] 透析を要するほど腎機能の低下したがん患者におけるイリノテカンの至適投与に向けた臨床研究2012
- Author(s)
  藤田健一
- Organizer
  第33回日本臨床薬理学会
- Place of Presentation
  那覇(シンポジウム)
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Characterization of hepatic uptake mechanism for SN-38, an active metabolite of the anticancer agent irinotecan in humans2012
- Author(s)
  Ken-ichi Fujita, Tomoko Sugiura, Saki Umeda, Hidenori Okumura, Noritaka Nakamichi, Yasutsuna Sasaki, Yukio Kato
- Organizer
  The 18th International Society for the Study of Xenobiotics North American Regional meeting
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] Involvement of OATP and inhibition by uremic toxins in hepatic uptake of an anticancer agent SN-38 in humans2012
- Author(s)
  Sugiura T, Fujita K, Okumura H, Umeda S, Nakamichi N, Sasaki Y, Kato Y
- Organizer
  27^<th> Japanese Society for the Study of Xenobiotics annual meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] 透析を要するほど腎機能の低下したがん患者におけるイリノテカンの至適投与に向けた臨床研究2012
- Author(s)
  藤田健一
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  那覇
- Invited
- Data Source
  KAKENHI-PROJECT-23590198
[Presentation] 転移性結腸・直腸がん一次治療の臨床及び経済的評価2011
- Author(s)
  安島秀友、緒方宏泰、藤田健一、高橋晴美、佐々木康綱
- Organizer
  第2回日本アプライド・セラピューティクス学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590652
[Presentation] Comparison of clinical outcome and overall costs for first-line FOLFIRI and modified FOLFOX62011
- Author(s)
  Ajima H, Ogata H, Fujita K, Sunakawa Y, Mizono K, Ishida H, Yamashita K, Nakayama H, Kawara K, Takahashi H and Sasaki Y
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590652
[Presentation] 大腸癌患者に対する5-FU+1-ロイコボリン+塩酸イリノテカン併用療法(FOLFIRI)の第I/II相試験とABCC2の遺伝薬理学的解析2008
- Author(s)
  藤田健一
- Organizer
  日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-20590546
[Presentation] Association of ABCC2 genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with FOLFIRI.2008
- Author(s)
  藤田健一
- Organizer
  米国癌学会(AACR)総会
- Place of Presentation
  米国サンディエゴ
- Year and Date
  2008-04-15
- Data Source
  KAKENHI-PROJECT-20590546
[Presentation] Association of ABCC2 genotype with pharmacokinetics of irinotecan in Japanese patients with metastatic colorectal cancer treated with FOLFIRI.2008
- Author(s)
  藤田健一
- Organizer
  米国癌学会(AACR)総会
- Place of Presentation
  サンディエゴ
- Year and Date
  2008-04-15
- Data Source
  KAKENHI-PROJECT-20590546
[Presentation] 尿毒症物質による肝膜輸送体OATP1B1の阻害様式．
- Author(s)
  小木達也，増尾友佑，藤田健一，北村正典，奥村英典，中道範隆，佐々木康綱，国嶋崇隆，加藤将夫
- Organizer
  第36回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2014-11-20 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] ssociation of pharmacokinetics or pharmacogenomics with toxicity of erlotinib in patients with advanced NSCLC
- Author(s)
  Takashi Hirose, Ken-ichi Fujita, Sojiro Kusumoto, Takao Shirai, Tomohide Sugiyama, Masanao Nakashima, Tohru Ohmori, Yasutsuna Sasaki, Atsuhisa Tamura , Ken Ohta
- Organizer
  第12回臨床腫瘍学会
- Data Source
  KAKENHI-PROJECT-23590648
[Presentation] 極めて腎機能が低下したがん患者において，SN-38の血漿蛋白結合は低下し遊離形濃度が顕著に上昇する．
- Author(s)
  藤田健一，増尾友祐，奥村英典，砂川優，嶋田顕，河原香織，秋山祐子，佐々木康綱，加藤将夫
- Organizer
  第35回日本臨床薬理学会学術総会
- Place of Presentation
  松山
- Year and Date
  2015-03-05 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] Change in plasma protein binding of SN-38, an active metabolite of irinotecan, in cancer patients with severe renal failure (SRF).
- Author(s)
  Ken-ichi Fujita, Hidenori Okumura, Yusuke Masuo, Yu Sunakawa, Ken Shimada, Kaori Kawara, Yuko Akiyama, Yasutsuna Sasaki, Yukio Kato
- Organizer
  The 39th European Society for Medical Oncology annual meeting
- Place of Presentation
  Madrid
- Year and Date
  2014-09-27 – 2014-09-30
- Data Source
  KAKENHI-PROJECT-26460205
[Presentation] 非小細胞肺癌に対するエルロチニブの毒性に影響を与える薬物動態、薬理遺伝学的検討
- Author(s)
  廣瀬敬, 藤田健一, 楠本壮二郎, 白井崇生, 村田泰則, 大木康成, 杉山智英, 石田博雄, 中嶌賢尚, 山岡利光, 奥田健太郎, 大西司, 大森亨, 佐々木康綱, 田村厚久, 大田健
- Organizer
  第54回日本呼吸器学会
- Data Source
  KAKENHI-PROJECT-23590648
[Presentation] Optimization of the dose of irinotecan in cancer patients with severe renal failure (SRF) based on physiologically-based pharmacokinetic (PBPK) model.
- Author(s)
  Ken-ichi Fujita, Yusuke Masuo, Hidenori Okumura, Yasutsuna Sasaki and Yukio Kato
- Organizer
  116th American Society for Clinical Pharmacology and Therapeutics annual meeting
- Place of Presentation
  New Orlearns
- Year and Date
  2015-03-05 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-26460205

1. KAMATAKI Tetsuya (00009177)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
2. ARIYOSHI Noritaka (00243957)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. NAKAYAMA Kazuo (20261323)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. SASAKI Yasutsuna (20235279)

# of Collaborated Projects: 7 results

# of Collaborated Products: 37 results
5. TAKAHASHI Yoshiki (80292019)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
6. YAMAZAKI Hiroshi (30191274)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
7. OKAZAKI Yasushi (80280733)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
8. KATO Yukio (30251440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
9. OGATA Hiroyasu (70133626)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. NAGASHIMA Fumio (70348209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. HIROSE Takashi (40307038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. TAKAHASHI Harumi (20211344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. SHIOMI Mari (30300768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NANJHO Shuji (70328615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ANDO Yuichi (10360083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YOKOI Tsuyoshi (70135226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KAMIDATE Tamio (70185990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. MIWA Masanao (20012750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TODOROKI Takeshi (70114105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. UCHIDA Kazuhiko (90211078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. Kusuhara Hiroyuki (00302612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
22. 大森亨 (10276529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
23. 山岡利光 (40384359)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 足立満 (10095870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 江角浩安 (70160364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 島田力 (50158961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 船江良彦 (00047268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 杉山雄一 (80090471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 川尻要 (50142112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 原田信広 (00189705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 佐久間勉 (30250468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. MINE Tsuyoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. KOBAYASHI Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. HONJO Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. LEE T.M. Michael

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. CAVALLARI Larisa H

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. UJJIN Pailin

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 増尾友佑

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Fujita Ken-ichi 藤田 健一

FUJITA Keniti 藤田 健一

FUJITA Ken-ichi 藤田 健一

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肝がん患者でのアルブミン低下と治療薬レンバチニブの遊離形体内動態・薬物応答の関連Principal Investigator

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Clinical impact of unbound-base pharmacokinetics of active metabolites of a tyrosine kinase inhibitor regorafenibPrincipal Investigator

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Mechanisms of delayed elimination and decreased plasma protein binding of anticancer drugs which are mainly eliminated via the liver in cancer patients with severe renal failurePrincipal Investigator

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Mechanism for the delayed elimination of SN-38 in cancer patients with severe renal failure and optimal treatment strategyPrincipal Investigator

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Factors causing interindividual variability in response to morphinePrincipal Investigator

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In vivo model to predict human fetal toxicity of xenobiotics : Establishment and evaluation of humanized mice carrying multiple forms of human fetal drug metabolizing enzymes.Principal Investigator

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Fujita Ken-ichi 藤田健一

FUJITA Keniti 藤田健一

FUJITA Ken-ichi 藤田健一