Okumura Toshikatsu 奥村利勝

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OKUMURA Toshikatsu 奥村利勝

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Researcher Number	60281903
Other IDs
External Links
Affiliation (Current)	2025: 旭川医科大学, 医学部, 理事
Affiliation (based on the past Project Information) *help	2002 – 2024: 旭川医科大学, 医学部, 教授 2000 – 2001: 旭川医科大学, 医学部, 講師 1999: 旭川医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology / Basic Section 52010:General internal medicine-related / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / General physiology / Basic Section 55020:Digestive surgery-related / Neurophysiology / General neuroscience / Neuroscience in general / Gastroenterology / Neurophysiology and muscle physiology / Science and Engineering
Keywords	Principal Investigator troglitazone / PPARgamma / 中枢神経 / 迷走神経 / ラット / オレキシン / グレリン / claudin / E-cadherin / PPARγ … More / 細胞増殖抑制 / skp2 / p27Kip1 / proteasome / orexin analogue / orexin / 過敏性腸症候群 / ドパミン / 内臓知覚 / cancer / 抗炎症作用 / 敗血症 / 敗血症死 / セロトニン / 腸管バリア機能 / オピオイド / 脳 / オキシトシン / Pancreas cancer / MEK-ERK signal / cell invasion / 抗腫瘍作用 / 細胞浸潤 / MEK-ERKシグナル / 膵臓癌 / growth inhibition / pancreatic cancer cells / mitogen-activated protein kinase kinase / extracellular signal releted kinase / アオトーシス / アポトーシス / MEK / 2 / ERK1 / 膵癌細胞 / 分 / プロテアソーム / 胃癌 / 肝臓癌 / 胃癌細胞 / structure-funtion relationship / binding affinity / disulfide band / vagus nerve / gatsric acid / orexin receptor / 神経ペプチド / 外側視床下部 / 摂食因子 / 脳相刺戟胃分泌 / orexinorexin受容体 / 構造活性相関 / 結合親和性 / SS結合 / 胃酸分泌 / orexin受容体 / 直腸伸展刺激 / カンナビノイド / アデノシン / がん細胞増殖 / 血管新生 / VEGF / 細胞増殖 / TRH / マイクロアレイ / 糖代謝 / hekisokinase / 遺伝子発現 / 肝臓 … More Except Principal Investigator サイトカイン / p38MAPK / 消化管運動 / LPS / アポトーシス / ゲムシタビン / 抗癌剤 / 膵癌 / 消化器癌 / 情動 / 歩行 / TLR4 / acquired chemoresistance / chemoresistance / Gemcitabine / p38 MAPK / COX-2 / 獲得耐性 / 治療抵抗性 / 内臓感覚 / 過敏性腸症候群 / CRF / オレキシン / 内臓知覚 / ストレス / 迷走神経 / EGFレセプター / 抗癌剤耐性 / パーキンソン病 / 大脳基底核 / 姿勢制御 / コリン性作動性ニューロン / histamine / 腸管バリア機能 / 脳血管バリアー / 術後せん妄 / NLRP3インフラマソーム / グレリン / SGLT2阻害薬 / 術後イレウス / 腸管透過性 / 消化管バリア / 内臓知覚過敏 / うつ病 / メタボリック症候群 / メタボリックシンドローム / 腸管バリアー / 腸管感覚 / GABA作動性経路 / ウイルスベクター / 視蓋脊髄路 / 脳深部刺激 / コリン作動性ニューロン / 中脳歩行誘発野 / 歩行誘発野 / 筋緊張 / 予期的姿勢調節 / 姿勢反射 / 姿勢筋緊張 / 脚橋被蓋核 / GABA作動性投射 / 黒質網様部 / 前庭脊髄路 / 網様体脊髄路 / EGF receptor / Aniticancer agents / pancereatic cancer / Gastreointestinal cancer / p37MAPK / Basal ganglia / Mesopontine tegmentum / Behavioral selection / REM sleep / Orexin / Narcolepsy / Locomotion / Emotion / カタプレキシp / 中脳被蓋 / 行動選択 / レム睡眠 / カタプレキシー / Anticancer agents / pancreatic cancer / GI cancer / AKT / 膵癌細胞 / 細胞内シグナル伝達 / INFLAMMATORY BOWEL DISEASE / PANETH CELL / a-DEFENSIN / ANTIMICROBIAL PEPTIDE / INTERNATIONAL SCIENCE EXCHANGE / innate immunity / IL-18R / NRAMP / paneth cell defensin / 内因性抗菌ペプチド / 粘膜防御 / 自然免疫 / defensin / 炎症性腸疾患 / Paneth細胞 / a-defensin / 抗菌ペプチド / 国際学術交流 / 胃運動 / 大腸運動 / CRF受容体 / IL-1 / dopamine / 睡眠 / 脳波 / 睡眠覚醒サイクル / 消化管機能 / 末梢CRF受容体 / 大腸収縮 / 胃収縮 / 臓器間相互作用 / 脂質代謝 / 糖質代謝 / 小腸モデル / マウス / TRPV / 中枢神経 / 脂肪肝 / シグナル伝達 / マイクロアレイ / vanin-1 / 肝脂肪 / コリン作動系 / コリン作動性 / 自律神経機能 / 運動機能 / 脳幹 / 大脳皮質 / 大脳皮質運動領域 / 四足歩行 / 二足歩行 / 自律神経系 / 適応 / ドーパミン / 随意運動 Less

脳内histamine神経系による腸管バリア制御機序の解明とleaky gut関連疾患への治療応用
- Principal Investigator
  
  石王応知
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
中枢神経系を介した敗血症死阻止メカニズムの解明　-Ghrelinの関与ーPrincipal Investigator
- Principal Investigator
  
  奥村利勝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Asahikawa Medical College
腹部手術後イレウスと術後せん妄に対する新規治療法の探究
- Principal Investigator
  
  野津司
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Asahikawa Medical College
Central mechanism of visceral sensation with special reference to brain orexin and its clinical application for irritable bowel syndromePrincipal Investigator
- Principal Investigator
  
  Okumura Toshikatsu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
Exploring novel therapies on the basis of pathophysiological commonality between irritable bowel syndrome and metabolic syndrome
- Principal Investigator
  
  Nozu Tsukasa
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
Roles of LPS, cytokine and peripheral CRF receptors on gastrointestinal function
- Principal Investigator
  
  Nozu Tsukasa
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Asahikawa Medical College
Role of brain orexin in the pathogenesis of irritable bowel syndromePrincipal Investigator
- Principal Investigator
  
  Toshikatsu Okumura
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Mechanisms of postural control operated by the basal ganglia, brainstem and spinal cord
- Principal Investigator
  
  Takakusaki Kaoru
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Asahikawa Medical College
The role and the mechanisms of orexin in modulating gastrointestinal function
- Principal Investigator
  
  NOZU Tsukasa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Asahikawa Medical College
Relationship between sleep-awake cycle and gastrointestinal motility
- Principal Investigator
  
  OHHIRA Masumi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Anti-tumor action by PPARgamma ligands in pancreatic cancer: analysis of angigenesis-related genes expressionPrincipal Investigator
- Principal Investigator
  
  OKUMURA Toshikatsu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
糖・脂質代謝研究に有用なin vitro小腸モデルの構築と臓器間相互作用の解析
- Principal Investigator
  
  吉崎隆之
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Kagoshima University
ストレスキナーゼp38MAPKを介した抗癌剤耐性機構の解析と癌治療への応用
- Principal Investigator
  
  TANNO Satoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
中枢性迷走神経刺激による肝臓で発現する遺伝子発現変化の網羅的解析Principal Investigator
- Principal Investigator
  
  奥村利勝
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
肝脂肪過剰蓄積を中枢へ伝達する迷走神経求心路刺激調節機構の解明と治療への応用
- Principal Investigator
  
  OHHIRA Masumi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Integrative control of psychomotor function and autonomic nervous system function by the basal ganglia
- Principal Investigator
  
  TAKAKUSAKI Kaoru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Asahikawa Medical College
Molecular mechanism of the PPARγ ligand-induced growth arrest in GI cancersPrincipal Investigator
- Principal Investigator
  
  OKUMURA Toshikatsu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
p38 MAPK signaling pathway-induced cell death in cancer chemotherapy
- Principal Investigator
  
  TANNO Satoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Neuronal mechanisms of initiation and selection of adaptive locomotor behaviors
- Principal Investigator
  
  TAKAKUSAKI Kaoru
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Asahikawa Medical College
Orexinergic systems responsible for the mechanisms of involved in the initiation and selection of emotional motor behaviors.
- Principal Investigator
  
  TAKAKUSAKI Kaoru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Asahikawa Medical College
Inhibition of cell growth and cell invasion by PPAR gamma in GI cancersPrincipal Investigator
- Principal Investigator
  
  OKUMURA Toshikatsu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Involvement of p38 MAPK signaling pathway in cancer therapy
- Principal Investigator
  
  TANNO Satoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Aproteasome-p27 system is involved in growth inhibition by PPARγ ligands in GI cancersPrincipal Investigator
- Principal Investigator
  
  OKUMURA Toshikatsu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Role of a novel neurppeptide, orexin,in the central regulation of gastric acid secretionPrincipal Investigator
- Principal Investigator
  
  OKUMURA Toshikatsu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
INTRINSIC ANTIMICROBIAL POLYPEPTIDE IN INFLAMMATROY BOWEL DISEASE
- Principal Investigator
  
  KOHGO Yutaka
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  ASAHIKAWA MEDICAL COLLEGE

[Book] Subcortical mechanisms of controlling muscle tone and locomotion with respect to the pathogenesis Cataplexy in Narcolepsy In : Narcolepsy ; Symptoms, Causes and Diagnosis and Treatment. (in Dress)
- Author(s)
  Takakusaki K, Okumura T, Kovama S
- Publisher
  Nova SciencePublishing Co. New York, USA
- Data Source
  KAKENHI-PROJECT-19500342
[Book] Subcortical mechanisms of controlling muscle tone and locomotion with respect to the pathogenesis Cataplexy in Narcolepsy In: Narcolepsy; Symptoms, Causes and Diagnosis and Treatment
- Author(s)
  Takakusaki K, Okumura T, Koyama S
- Publisher
  Nova Science Publishing Co. New York, USA(in press)
- Data Source
  KAKENHI-PROJECT-19500342
[Book] Subcortical mechanisms of controlling muscle tone and locomotion with respect to the pathogenesis Cataplexy in Narcolepsy In : Narcolepsy ; Symptoms, Causes and Diagnosisaand Treatment
- Author(s)
  Takakusaki K, Okumura T, Koyama S
- Publisher
  Nova Science Publishing Co. New York USA(in press)
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Brain Neuropeptides, Neuroinflammation, and Irritable Bowel Syndrome2024
- Author(s)
  Ishioh, M. Nozu, T. Okumura, T.
- Journal Title
  
  Digestion
  
  Volume: 105 Issue: 1 Pages: 34-39
- DOI
  10.1159/000533275
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08790, KAKENHI-PROJECT-21K07883
[Journal Article] Phlorizin attenuates postoperative gastric ileus in rats2023
- Author(s)
  Nozu, T. Miyagishi, S. Ishioh, M. Takakusaki, K. Okumura, T.
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 35 Issue: 11
- DOI
  10.1111/nmo.14659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08790
[Journal Article] Ghrelin prevents lethality in a rat endotoxemic model through central effects on the vagal pathway and adenosine A2B signaling : Brain ghrelin and anti-septic action.2023
- Author(s)
  Igarashi S, Nozu T, Ishioh M, Funayama T, Sumi C, Saito T, Toki Y, Hatayama M, Yamamoto M, Shindo M, Tanabe H, Okumura T.
- Journal Title
  
  J Physiol Biochem.
  
  Volume: - Issue: 3 Pages: 625-634
- DOI
  10.1007/s13105-023-00962-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08746, KAKENHI-PROJECT-23K06842
[Journal Article] Imeglimin prevents visceral hypersensitivity and colonic hyperpermeability in irritable bowel syndrome rat model2023
- Author(s)
  Nozu, Tsukasa Miyagishi, Saori Ishioh, Masatomo Takakusaki, Kaoru Okumura, Toshikatsu
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 153 Issue: 1 Pages: 26-30
- DOI
  10.1016/j.jphs.2023.07.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08790
[Journal Article] Peripheral apelin mediates visceral hypersensitivity and impaired gut barrier in a rat irritable bowel syndrome model2022
- Author(s)
  Nozu, T. Miyagishi, S. Ishioh, M. Takakusaki, K. Okumura, T.
- Journal Title
  
  Neuropeptides
  
  Volume: 94 Pages: 102248-102248
- DOI
  10.1016/j.npep.2022.102248
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PROJECT-22K08790, KAKENHI-PLANNED-19H05726
[Journal Article] Pathophysiological Commonality Between Irritable Bowel Syndrome and Metabolic Syndrome: Role of Corticotropin-releasing Factor-Toll-like Receptor 4-Proinflammatory Cytokine Signaling2022
- Author(s)
  Nozu, T. Okumura, T.
- Journal Title
  
  J Neurogastroenterol Motil
  
  Volume: 28 Issue: 2 Pages: 173-184
- DOI
  10.5056/jnm21002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PROJECT-22K08790
[Journal Article] EMA401, an angiotensin II type 2 receptor antagonist blocks visceral hypersensitivity and colonic hyperpermeability in rat model of irritable bowel syndrome2021
- Author(s)
  Nozu, T. Miyagishi, S. Nozu, R. Ishioh, M. Takakusaki, K. Okumura, T.
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 146 Issue: 3 Pages: 121-124
- DOI
  10.1016/j.jphs.2021.04.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-19H05726
[Journal Article] Activation of central adenosine A2B receptors mediate brain ghrelin-induced improvement of intestinal barrier function through the vagus nerve in rats2021
- Author(s)
  Ishioh Masatomo、Nozu Tsukasa、Igarashi Sho、Tanabe Hiroki、Kumei Shima、Ohhira Masumi、Takakusaki Kaoru、Okumura Toshikatsu
- Journal Title
  
  Experimental Neurology
  
  Volume: 341 Pages: 113708-113708
- DOI
  10.1016/j.expneurol.2021.113708
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08410, KAKENHI-PLANNED-19H05726, KAKENHI-PROJECT-21K07883
[Journal Article] Central regulatory mechanisms of visceral sensation in response to colonic distension with special reference to brain orexin2021
- Author(s)
  Okumura Toshikatsu、Ishioh Masatomo、Nozu Tsukasa
- Journal Title
  
  Neuropeptides
  
  Volume: 86 Pages: 102129-102129
- DOI
  10.1016/j.npep.2021.102129
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] Phlorizin attenuates visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome2021
- Author(s)
  Nozu, T. Miyagishi, S. Ishioh, M. Takakusaki, K. Okumura, T.
- Journal Title
  
  Biomed Pharmacother
  
  Volume: 139 Pages: 111649-111649
- DOI
  10.1016/j.biopha.2021.111649
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-19H05726
[Journal Article] 5-HT2A receptors but not cannabinoid receptors in the central nervous system mediate levodopa-induced visceral antinociception in conscious rats.2020
- Author(s)
  Okumura T, Nozu T, Ishioh M, Igarashi S, Kumei S, Ohhira M.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] Losartan improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome2020
- Author(s)
  Nozu Tsukasa、Miyagishi Saori、Nozu Rintaro、Takakusaki Kaoru、Okumura Toshikatsu
- Journal Title
  
  Neurogastroenterology & Motility
  
  Volume: in press Issue: 6 Pages: 0-0
- DOI
  10.1111/nmo.13819
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-19H05726, KAKENHI-PROJECT-19K08410
[Journal Article] Adenosine A1 receptor agonist induces visceral antinociception via 5-HT1A, 5-HT2A, dopamine D1 or cannabinoid CB1 receptors, and the opioid system in the central nervous system2020
- Author(s)
  Okumura Toshikatsu、Nozu Tsukasa、Ishioh Masatomo、Igarashi Sho、Kumei Shima、Ohhira Masumi
- Journal Title
  
  Physiology & Behavior
  
  Volume: 220 Pages: 112881-112881
- DOI
  10.1016/j.physbeh.2020.112881
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] Ghrelin acts in the brain to block colonic hyperpermeability in response to lipopolysaccharide through the vagus nerve2020
- Author(s)
  Ishioh Masatomo、Nozu Tsukasa、Igarashi Sho、Tanabe Hiroki、Kumei Shima、Ohhira Masumi、Okumura Toshikatsu
- Journal Title
  
  Neuropharmacology
  
  Volume: 173 Pages: 108116-108116
- DOI
  10.1016/j.neuropharm.2020.108116
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] 5-HT2A receptors but not cannabinoid receptors in the central nervous system mediate levodopa-induced visceral antinociception in conscious rats2020
- Author(s)
  Okumura Toshikatsu、Nozu Tsukasa、Ishioh Masatomo、Igarashi Sho、Kumei Shima、Ohhira Masumi
- Journal Title
  
  Naunyn-Schmiedeberg's Archives of Pharmacology
  
  Volume: 393 Issue: 8 Pages: 1419-1425
- DOI
  10.1007/s00210-020-01842-0
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] Centrally administered orexin prevents lipopolysaccharide and colchicine induced lethality via the vagal cholinergic pathway in a sepsis model in rats2020
- Author(s)
  Igarashi Sho、Nozu Tsukasa、Ishioh Masatomo、Kumei Shima、Saito Takeshi、Toki Yasumichi、Hatayama Mayumi、Yamamoto Masayo、Shindo Motohiro、Tanabe Hiroki、Okumura Toshikatsu
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 182 Pages: 114262-114262
- DOI
  10.1016/j.bcp.2020.114262
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08410
[Journal Article] Imipramine improves visceral sensation and gut barrier in rat models of irritable bowel syndrome2020
- Author(s)
  Nozu, T. Miyagishi, S. Ishioh, M. Takakusaki, K. Okumura, T.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 887 Pages: 173565-173565
- DOI
  10.1016/j.ejphar.2020.173565
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PROJECT-19K08410, KAKENHI-PLANNED-19H05726
[Journal Article] Brain orexin improves intestinal barrier function via the vagal cholinergic pathway2020
- Author(s)
  Okumura Toshikatsu、Nozu Tsukasa、Ishioh Masatomo、Igarashi Sho、Kumei Shima、Ohhira Masumi
- Journal Title
  
  Neuroscience Letters
  
  Volume: 714 Pages: 134592-134592
- DOI
  10.1016/j.neulet.2019.134592
- Open Access
- Data Source
  KAKENHI-PROJECT-19K08410, KAKENHI-PROJECT-18K15739
[Journal Article] Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome.2019
- Author(s)
  Nozu T, Miyagishi S, Nozu R, Takakusaki K, Okumura T.
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 852 Pages: 198-206
- DOI
  10.1016/j.ejphar.2019.03.037
- NAID
  120006878173
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-19H05726
[Journal Article] Butyrate inhibits visceral allodynia and colonic hyperpermeability in rat models of irritable bowel syndrome2019
- Author(s)
  Nozu Tsukasa、Miyagishi Saori、Nozu Rintaro、Takakusaki Kaoru、Okumura Toshikatsu
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 19603-19603
- DOI
  10.1038/s41598-019-56132-4
- NAID
  120006775256
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-19H05726
[Journal Article] Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats2019
- Author(s)
  Nozu, T. Miyagishi, S. Kumei, S. Nozu, R. Takakusaki, K. Okumura, T.
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 34 Issue: 1 Pages: 186-193
- DOI
  10.1111/jgh.14367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-26120004
[Journal Article] Ghrelin acts centrally to induce an antinociceptive action during colonic distension through the orexinergic, dopaminergic and opioid systems in conscious rats.2018
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Ohhira M.
- Journal Title
  
  Brain Res.
  
  Volume: 1686 Pages: 48-54
- Data Source
  KAKENHI-PROJECT-26460955
[Journal Article] Altered colonic sensory and barrier functions by CRF: roles of TLR4 and IL-12018
- Author(s)
  Nozu, T. Miyagishi, S. Nozu, R. Takakusaki, K. Okumura, T.
- Journal Title
  
  J Endocrinol
  
  Volume: 239 Issue: 2 Pages: 241-151
- DOI
  10.1530/joe-18-0441
- NAID
  120006769835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-26120004
[Journal Article] A Hypothesis for Understanding Mechanisms of Normal and Abnormal Behavior States Based on Operation Hypothesis.2018
- Author(s)
  Takakusaki K, Takahashi M, Nakajima T, Chiba R, Obara K, Nozu T, Okumura T
- Journal Title
  
  Sleep Med Dis Int J
  
  Volume: 2(1) Issue: 1 Pages: 00031-00031
- DOI
  10.15406/smdij.2018.02.00031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004
[Journal Article] Pioglitazone improves visceral sensation and colonic permeability in a rat model of irritable bowel syndrome2018
- Author(s)
  Nozu, T. Miyagishi, S. Nozu, R. Takakusaki, K. Okumura, T.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 139 Issue: 1 Pages: 46-49
- DOI
  10.1016/j.jphs.2018.11.006
- NAID
  120006643359
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07896, KAKENHI-PLANNED-26120004, KAKENHI-PLANNED-19H05726
[Journal Article] Ghrelin acts centrally to induce an antinociceptive action during colonic distension through the orexinergic, dopaminergic and opioid systems in conscious rats.2018
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Ohhira M.
- Journal Title
  
  Brain Res.
  
  Volume: 1686 Pages: 48-54
- DOI
  10.1016/j.brainres.2018.02.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004
[Journal Article] Lovastatin inhibits visceral allodynia and increased colonic permeability induced by lipopolysaccharide or repeated water avoidance stress in rats.2018
- Author(s)
  Nozu T, Miyagishi S, Kumei S, Nozu R, Takakusaki K, Okumura T
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 818 Pages: 228-234
- DOI
  10.1016/j.ejphar.2017.10.056
- NAID
  120006552898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PROJECT-26460287
[Journal Article] Lipopolysaccharide induces visceral hypersensitivity: role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor in rats.2017
- Author(s)
  Nozu T, Miyaghisi S, Nozu R, Takakusaki K, Okumura T.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 80(5) Issue: 1 Pages: 70-82
- DOI
  10.1007/s00535-016-1208-y
- NAID
  120006220854
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001, KAKENHI-PROJECT-26460287
[Journal Article] Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor2017
- Author(s)
  Nozu T, Miyagishi S, Nozu R, Takakusaki K, Okumura T.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: in press Issue: 12 Pages: 1958-1965
- DOI
  10.1111/jgh.13787
- NAID
  120006425800
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001, KAKENHI-PROJECT-26460287
[Journal Article] A glucagon-like peptide-1 analog, liraglutide improves visceral sensation and gut permeability in rats2017
- Author(s)
  Nozu T, Miyagishi S, Kumei S, Nozu R, Takakusaki K, Okumura T.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: in press Issue: 1 Pages: 232-239
- DOI
  10.1111/jgh.13808
- NAID
  120006462336
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001, KAKENHI-PROJECT-26460287
[Journal Article] Lipopolysaccharide induces visceral hypersensitivity: role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor in rats.2016
- Author(s)
  Nozu T, Miyagishi S, Nozu R, Takakusaki K, Okumura T.
- Journal Title
  
  J Gastroenterol (in press)
  
  Volume: in press
- NAID
  120006220854
- Data Source
  KAKENHI-PROJECT-25290001
[Journal Article] Levodopa acts centrally to induce an antinociceptive action against colonic distension through activation of D2 dopamine receptors and the orexinergic system in the brain in conscious rats.2016
- Author(s)
  2.Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 130(2): Pages: 123-127
- NAID
  120005763350
- Data Source
  KAKENHI-PROJECT-26460955
[Journal Article] Water avoidance stress induces visceral hyposensitivity through peripheral corticotropin releasing factor receptor type 2 and central dopamine D2 receptor in rats2016
- Author(s)
  Nozu, T. Miyagishi, S. Nozu, R. Takakusaki, K. Okumura, T.
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 28 Issue: 4 Pages: 522-531
- DOI
  10.1111/nmo.12747
- NAID
  120005941041
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460287, KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001
[Journal Article] Levodopa acts centrally to induce an antinociceptive action against colonic distension through activation of D2 dopamine receptors and the orexinergic system in the brain in conscious rats.2016
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 130 Issue: 2 Pages: 123-127
- DOI
  10.1016/j.jphs.2016.01.007
- NAID
  120005763350
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004
[Journal Article] Adenosine A1 receptors mediate the intracisternal injection of orexin-induced antinociceptive action against colonic distension in conscious rats.2016
- Author(s)
  1.Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 362 Pages: 106-110
- Data Source
  KAKENHI-PROJECT-26460955
[Journal Article] Brainstem control of locomotion and muscle tone with special reference to the role of the mesopontine tegmentum and medullary reticulospinal systems.2016
- Author(s)
  Takakusaki K, Chiba R, Nozu T, Okumura T.
- Journal Title
  
  J Neural Transm
  
  Volume: in press Issue: 7 Pages: 695-729
- DOI
  10.1007/s00702-015-1475-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PLANNED-26120006, KAKENHI-PROJECT-25290001
[Journal Article] Adenosine A1 receptors mediate the intracisternal injection of orexin-induced antinociceptive action against colonic distension in conscious rats.2016
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 362 Pages: 106-110
- DOI
  10.1016/j.jns.2016.01.031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001
[Journal Article] Colorectal distention induces acute and delayed visceral hypersensitivity: role of peripheral corticotropin-releasing factor and interleukin-1 in rats2015
- Author(s)
  Nozu, T. Kumei, S. Miyagishi, S. Takakusaki, K. Okumura, T.
- Journal Title
  
  J Gastroenterol
  
  Volume: 50 Issue: 12 Pages: 1153-1161
- DOI
  10.1007/s00535-015-1070-3
- NAID
  120005740467
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460287, KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001
[Journal Article] Antinociceptive action against colonic distension by brain orexin in conscious rats2015
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M
- Journal Title
  
  Brain Research
  
  Volume: 1598 Pages: 12-17
- DOI
  10.1016/j.brainres.2014.12.021
- NAID
  120005712587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-26460955
[Journal Article] Involvement of the dopaminergic system in the central orexin-induced anitinociceptive action aganist colonic distension in conscious rat.2015
- Author(s)
  Okumura T　Nozu T　Kumiei S, Takakusaki K, Miyagishi S,Ohhira M,
- Journal Title
  
  Neurosci Lett.
  
  Volume: 605 Pages: 34-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460955
[Journal Article] Corticotropin-releasing factor receptor type 1 and type 2 interaction in irritable bowel syndrome2015
- Author(s)
  Nozu, T. Okumura, T.
- Journal Title
  
  J Gastroenterol
  
  Volume: 50 Issue: 8 Pages: 819-830
- DOI
  10.1007/s00535-015-1086-8
- NAID
  120005941030
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460287
[Journal Article] Involvement of the dopaminergic system in the central orexin-induced antinociceptive action against colonic distension in conscious rats.2015
- Author(s)
  Okumura T, Nozu T, Kumei S, Takakusaki K, Miyagishi S, Ohhira M.
- Journal Title
  
  Neurosci Lett.
  
  Volume: 605 Pages: 34-38
- DOI
  10.1016/j.neulet.2015.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-25290001
[Journal Article] Colorectal distention induces acute and delayed visceral hypersensitivity: role of peripheral corticotropin-releasing factor and interleukin-1 in rats2015
- Author(s)
  Nozu T, Kumei S, Miyagishi S, Takakusaki K, Okumura T
- Journal Title
  
  J Gastroenterol
  
  Volume: 印刷中
- NAID
  120005740467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25290001
[Journal Article] A balance theory of peripheral corticotropin-releasing factor receptor type 1 and type 2 signaling to induce colonic contractions and visceral hyperalgesia in rats2014
- Author(s)
  Nozu T, Takakusaki K, Okumura T
- Journal Title
  
  Endocrinology
  
  Volume: 155 Issue: 12 Pages: 4655-4664
- DOI
  10.1210/en.2014-1421
- NAID
  120005690949
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-26460287
[Journal Article] Urocortin 2 blocks the suppression of gastric antral contractions induced by lipopolysaccharide in freely moving conscious rats2014
- Author(s)
  Nozu T, Takakusaki K, Okumura T
- Journal Title
  
  Regulatory Peptides
  
  Volume: (in press) Pages: 12-17
- DOI
  10.1016/j.regpep.2014.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252, KAKENHI-PROJECT-23650202, KAKENHI-PROJECT-25290001, KAKENHI-PLANNED-26120004, KAKENHI-PROJECT-26460287
[Journal Article] Peripheral corticotropin-releasing factor (CRF) induces stimulation of gastric contractions in freely moving conscious rats: role of CRF receptor types 1 and 2.2013
- Author(s)
  Nozu T, Tsuchiya Y, Kumei S, Takakusaki K, Okumura T.
- Journal Title
  
  Neurogastroenterology and Motility
  
  Volume: 25 Issue: 2 Pages: 190-197
- DOI
  10.1111/nmo.12050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252, KAKENHI-PROJECT-23650202, KAKENHI-PROJECT-25290001
[Journal Article] Water-avoidance stress enhances gastric contractions in freely moving conscious rats: role of peripheral CRF receptors. J2013
- Author(s)
  Tsukasa Nozu, Shima Kumei, Kaoru Takakusaki, Toshikatsu Okumura
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 48 Issue: 5 Pages: 1-7
- DOI
  10.1007/s00535-013-0828-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650202, KAKENHI-PROJECT-25290001
[Journal Article] Peripheral corticotropin-releasing factor (CRF) induces stimulation of gastric contractions in freely moving conscious rats : role of CRF receptor types 1 and 22013
- Author(s)
  Nozu T, Tsuchiya Y, Kumei S, Takakusaki K, Okumura T
- Journal Title
  
  Neurogastroenterol. Motil
  
  Volume: 25 Pages: 190-197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Journal Article] Water-avoidance stress enhances gastric contractions in freely moving conscious rats : role of peripheral CRF receptors2013
- Author(s)
  Nozu T, Kumei S, Takakusaki K, Okumura T
- Journal Title
  
  J. Gastroenterol
  
  Volume: (in press)
- NAID
  120006658779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Journal Article] IL-1 receptor antagonist blocks the lipopolysaccharide-induced inhibition of gastric motility in freely moving conscious rats2012
- Author(s)
  Tsuchiya Y, Nozu T, Kumei S, Ohhira M, Okumura T
- Journal Title
  
  Dig. Dis. Sci
  
  Volume: 57 Pages: 2555-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Journal Article] IL-1 receptor antagonist blocks thelipopolysaccharide-induced inhibition ofgastric motility in freely movingconscious rats2012
- Author(s)
  Tsuchiya Y, Nozu T, Kumei S, Ohhira M, Okumura T.
- Journal Title
  
  Dig Dis Sci
  
  Volume: 57(10) Pages: 2555-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659391
[Journal Article] Endogenous orexin-A in the brain mediates 2-deoxy-D-glucose-induced stimulation of gastric motility in freely moving conscious rats2012
- Author(s)
  Nozu T, Tuchiya Y, Kumei S, Takakusaki K, Ataka K, Fujimiya M, Okumura T
- Journal Title
  
  J. Gastroenterol
  
  Volume: 47 Pages: 404-411
- NAID
  10030650004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Journal Article] IL-1 receptor antagonist blocks the lipopolysaccharide-induced inhibition of gastric motility in freely moving conscious rats.2012
- Author(s)
  Tsuchiya Y, Nozu T, Kumei S, Ohhira M, Okumura T.
- Journal Title
  
  Dig Dis Sci.
  
  Volume: Oct;57(10) Pages: 2555-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659391
[Journal Article] IL-1 receptor antagonist blocks the lipopolysaccharide-induced inhibition of gastric motility in freely moving conscious rats.2012
- Author(s)
  Tsuchiya Y, Nozu T, Kumei S, Ohhira M, Okumura T.
- Journal Title
  
  Digestive Diseases and Sciences
  
  Volume: 57 Issue: 10 Pages: 2555-2561
- DOI
  10.1007/s10620-012-2210-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Journal Article] Endogenous orexin-A in the brain mediates 2-deoxy-D-glucose-induced stimulation of gastric motility in freely moving conscious rats.2012
- Author(s)
  Nozu T, Tuchiya Y, Kumei S, Takakusaki K, Ataka K, Fujimiya M, Okumura T.
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 47 Issue: 4 Pages: 404-411
- DOI
  10.1007/s00535-011-0506-7
- NAID
  10030650004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252, KAKENHI-PROJECT-23650202
[Journal Article] Central orexin-A increases colonic motility in conscious rats2011
- Author(s)
  Nozu T, Kumei S, Takakusaki K, Ataka K, Fujimiya M, Okumura T
- Journal Title
  
  Neurosci. Lett
  
  Volume: 498 Pages: 143-6
- NAID
  120004461833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590252
[Journal Article] Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs2010
- Author(s)
  Okumura T
- Journal Title
  
  J Gastroenterol
  
  Volume: 45 Pages: 1097-102
- NAID
  10027699617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590753
[Journal Article] Anti-cancer action by PPARgamma ligand2010
- Author(s)
  Okumura T
- Journal Title
  
  Nihon Rinsho
  
  Volume: 68 Pages: 267-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590753
[Journal Article] Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs.2010
- Author(s)
  Okumura T
- Journal Title
  
  J Gastroenterol
  
  Volume: 45
- NAID
  10027699617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590753
[Journal Article] Prevalence of functional dyspepsia in an outpatient clinic with primary care physicians in Japan2010
- Author(s)
  Okumura T, Tanno S, Ohhira M, Tanno S
- Journal Title
  
  J Gastroenterol 45
  
  Pages: 187-184
- NAID
  10027214531
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Frequent early discontinuation of SSRI prescribed by primary care physicians in young males in Japan2010
- Author(s)
  Tanno S, Ohhira M, Tsuchiya Y, Takeuchi T, Tanno S, Okumura T
- Journal Title
  
  Intern Med 48
  
  Pages: 1263-1266
- NAID
  130000121951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Thiazolidinediones enhance vascular endothelial growth factor expression and induce cell growth inhibition in non-small-cell lung cancer cells2010
- Author(s)
  Yoshizaki T, Motomura W, Tanno S, Kumei S, Yoshizaki Y, Tanno S, Okumura T
- Journal Title
  
  J Exp Clin Cancer Res
  
  Volume: 29 Pages: 22-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590753
[Journal Article] A Jak2 inhibitor, AG490reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes2009
- Author(s)
  Tsuchiya Y, Takahashi N, Yoshizaki T, Tanno S, Ohhira M, Motomura W, Tanno S, Takakusaki K, Kohgo Y, Okumura T.
- Journal Title
  
  Biochem Biophysics Res Comm (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes2009
- Author(s)
  Tsuchiya Y, Takahashi N, Yoshizaki T, Tanno S, Ohhira M, Motomura W, Tanno S, Takakusaki K, Kohgo Y, Okumura T.
- Journal Title
  
  Biochemistry and Biophysics Research Communication (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes.2009
- Author(s)
  Tsuchiya Y, Okumura T
- Journal Title
  
  Biochem Biophys Res Commun 382
  
  Pages: 348-352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659113
[Journal Article] A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes2009
- Author(s)
  Tsuchiya Y, Takahashi N, Yoshizaki T, Tanno S, Ohhira M, Motomura W, Tanno S, Takakusaki K, Kohgo Y, Okumura T
- Journal Title
  
  Biochemical and Biophysical Research Communications 380
  
  Pages: 614-619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells2009
- Author(s)
  Kumei S, Motomura W, Yoshizaki T, Takakusaki K, Okumura T.
- Journal Title
  
  Biochem Biophysics Res Comm 386
  
  Pages: 615-619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells.2009
- Author(s)
  Kumei S, Okumura T
- Journal Title
  
  Biochem Biophys Res Commun 380
  
  Pages: 614-619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659113
[Journal Article] Troglitazone increases expression of Ecadherin and claudin 4 in human pancreatic cancer cells2009
- Author(s)
  Kumei S, Motomura W, Yoshizaki T, Takakusaki K, Okumura T
- Journal Title
  
  Biochemistry and Biophysics Research Communication 386
  
  Pages: 615-619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells2009
- Author(s)
  Kumei S, Motomura W, Yoshizaki T, Takakusaki K, Okumura T
- Journal Title
  
  Biochemical and Biophysical Research Communications 382
  
  Pages: 615-619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes2009
- Author(s)
  Tsuchiya Y, Takahashi N, Yoshizaki T, Tanno S, Ohhira M, Motomura W, Tanno S. Takakusaki K. Koheo Y. Okumura T.
- Journal Title
  
  Biochemistry and Biophysics Research Communication (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] Troglitazone increases expression of E-cadherin and claudin 4 in human nancreatic cancer cells.2009
- Author(s)
  Kumei S. Motomura W, Yoshizaki T, Takakusaki K, Okumura T.
- Journal Title
  
  Biochemistry and Biophysics Research Communication 386
  
  Pages: 615-619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] Role of orexin in central regulation of gastrointestinal functions2008
- Author(s)
  Okumura T., Takakusaki K Toledo Salas JC, Iwasaki H, Jodo E, Schmidt MH, Kawauchi A, Miki T
- Journal Title
  
  J Gastroenterol 43
  
  Pages: 652-660
- NAID
  10022609508
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] 運動機能から観た哺乳類の睡眠制御メカニズム2008
- Author(s)
  高草木薫, 奥村利勝, 小山純正
- Journal Title
  
  細胞工学 27
  
  Pages: 449-455
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] 運動機能から観た哺乳類の睡眠制御メカニズム2008
- Author(s)
  高草木薫, 奥村利勝, 小山純正
- Journal Title
  
  細胞工学 27(5)(印刷中)
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] 消化とホルモン2008
- Author(s)
  奥村利勝
- Journal Title
  
  臨床検査 52
  
  Pages: 1337-1342
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Role of orexin in central regulation of gastrointestinal functions.2008
- Author(s)
  Okumura T, Takakusaki K
- Journal Title
  
  Journal of Gastroenterology 43
  
  Pages: 652-660
- NAID
  10022609508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] Neurobiological basis of locomotion in mammals2008
- Author(s)
  Takakusaki K, Okumura T
- Journal Title
  
  Advanced Robotics 22
  
  Pages: 1629-1663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] Natural History of Branch Duct Intraductal PapillaryMucinous Neoplasms of the Pancreas without Mural Nodules : Long-term Follow-up Results2008
- Author(s)
  Tanno S, Nakano Y, Nishikawa T, Nakamura K, Sasajima J, Minoguchi M, Mizukami Y, Yanagawa N, Fujii T, Obara T, Okumura T, Kohgo Y
- Journal Title
  
  Gut 57
  
  Pages: 339-660
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] 脳腸相関からみた機能性胃腸症2008
- Author(s)
  奥村利勝
- Journal Title
  
  日本医事新報 4382
  
  Pages: 60-70
- NAID
  40015965861
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Neurobiological basis of controlling posture and locomotion2008
- Author(s)
  Takakusaki K., Okumura T.
- Journal Title
  
  Adv Robot 22
  
  Pages: 1629-1663
- NAID
  10025777413
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Neurobiological basis of locomotion in mammals2008
- Author(s)
  I Takakusaki K, Okumura T
- Journal Title
  
  Advanced Robotics 22
  
  Pages: 1629-1663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Role of orexin in central regulation of gastrointestinal functions2008
- Author(s)
  Okumura T, Takakusaki K.
- Journal Title
  
  J Gastroenterol 43
  
  Pages: 652-660
- NAID
  10022609508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] 運動機能から観た哺乳類の睡眠制御メカニズム2008
- Author(s)
  高草木薫, 奥村利勝, 小山純正
- Journal Title
  
  細胞工学 27
  
  Pages: 449-455
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] 運動機能から観た哺乳類の睡眠制御メカニズム2008
- Author(s)
  高草木薫, 奥村利勝, 小山純正
- Journal Title
  
  細胞工学 27(5)(印刷中)
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] Neurobiological basis of locomotion in mammals2008
- Author(s)
  Takakusaki K, Okumura T.
- Journal Title
  
  Adv Rob 22
  
  Pages: 1629-1663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] 運動機能から観た哺乳類の睡眠制御メカニズム2008
- Author(s)
  高草木薫, 奥村利勝, 小山純
- Journal Title
  
  細胞工学 27
  
  Pages: 449-455
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] Natural History of Branch Duct Intraductal Papillary-Mucinous Neoplasms of the Pancreas without Mural Nodules : Long-term Follow-uu Results2008
- Author(s)
  Tanno S, Okumura T
- Journal Title
  
  Gut 57
  
  Pages: 339-343
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659113
[Journal Article] Role of orexin in central regulation of gastrointestinal functions2008
- Author(s)
  Okumura T. Takakusaki K
- Journal Title
  
  Journal of Gastroenterology 43
  
  Pages: 652-660
- NAID
  10022609508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Role of orexin in central regulation of gastrointestinal functions2008
- Author(s)
  Okumura T, Takakusaki K
- Journal Title
  
  J Gastroenterol 43
  
  Pages: 652-660
- NAID
  10022609508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659113
[Journal Article] Tissue distribution of a collectin CL-K1 in murine tissues2008
- Author(s)
  Motomura W, Yoshizaki T, Ohtani K, Okumura T, et.al.
- Journal Title
  
  Journal of Histchemistry. and Cytochemistry 56
  
  Pages: 243-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Intracisternal injection of orexin-A prevents ethanol-induced gastric mucosal damage in rats2007
- Author(s)
  Yamada H, Tanno S, Takakusaki K, Okumura T.
- Journal Title
  
  Journal of Gastroenterology 42
  
  Pages: 336-341
- NAID
  10019482959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] Intracisternal injection of orexin-A prevents ethanol-induced gastric mucosal damage in rats2007
- Author(s)
  Yamada H, Tanno S, Takakusaki K, Okumura T.
- Journal Title
  
  J Gatroenterol 42
  
  Pages: 336-341
- NAID
  10019482959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500342
[Journal Article] Intracisternal injection of orexin-A prevents ethanol-induced gastric mucosal damage in rats2007
- Author(s)
  Yamada H, Tanno S, Takakusaki K. Okumura T.
- Journal Title
  
  Journal of Gastroenterology 42
  
  Pages: 336-341
- NAID
  10019482959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Neurobiological basis of state-dependent control of motor behavior.2006
- Author(s)
  Takakusaki K, Saitoh K, Nonaka S, Okumura T, Miyokawa N, Koyama Y.
- Journal Title
  
  Sleep Biol Rhyth 4
  
  Pages: 87-104
- NAID
  120003203391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500197
[Journal Article] Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet.2006
- Author(s)
  Motomura W, Inoue M, Ohtake T, Takahashi N Nagamine M, Tanno S, Kohgo Y, Okumura T.
- Journal Title
  
  Biochem Biophys Res Com 340
  
  Pages: 1111-1118
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500197
[Journal Article] Neurobiological basis of state-dependent control of motor behavior2006
- Author(s)
  Takakusaki K, Saitoh K, Nonaka S, Okumura T, Miyokawa N, Koyama Y. Kodama T
- Journal Title
  
  Sleep Biol Rhyth 4
  
  Pages: 87-104
- NAID
  120003203391
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Involvement of MEK-ERK signaling pathway in the inhibition of cell growth by troglitazone in human pancreatic cancer cells.2006
- Author(s)
  Motomura W, Tanno S, Takahashi N, Nagamine M, Fukuda M, Kohgo Y, Okumura T.
- Journal Title
  
  Biochem Biophys Res Com 332
  
  Pages: 89-94
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500197
[Journal Article] A Phase I study of oral UFT prior to weekly intravenous gemcitabine in patients with advanced pancreatic cancer.2006
- Author(s)
  Tanno S, Nakano Y, Osanai M, Koizumi K, Izawa T, Habiro A, Mizukami Y, Yanagawa N, Fujii T, Okumura T, Kohgo Y
- Journal Title
  
  Chemotherapy 52
  
  Pages: 98-102
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500197
[Journal Article] A selective orexin-1 receptor antagonist, SB-334867, blocks 2-DG-induced gastric acid secretion in rats2005
- Author(s)
  Yamada H, Takahashi N, Tanno S, Nagamine M, Takakusaki K, Okumura T.
- Journal Title
  
  Neurosci Lett 376
  
  Pages: 137-142
- NAID
  120003132237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500197
[Journal Article] Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy.2005
- Author(s)
  Takakusaki K, Takahashi K, Saitoh K, Harada H, Okumura T, Kayama Y, Koyama Y.
- Journal Title
  
  J Physiol 568
  
  Pages: 1003-1020
- NAID
  120003203397
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500197
[Journal Article] Increased expression of PPARg in high fat diet-induced liver steatosis in mice.2005
- Author(s)
  Inoue M, Ohtake T, Motomura W, Takahashi N, Hosoki Y, Miyoshi S, Suzuki Y, Saito H, Kohgo Y, Okumura T.
- Journal Title
  
  Biochem Biophys Res Com 336
  
  Pages: 215-222
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500197
[Journal Article] Brain or gut? : Site of action of adrenomedullin to regulate gut motility.2005
- Author(s)
  Okumura T.
- Journal Title
  
  J Gastroenterol 40
  
  Pages: 1161-1162
- NAID
  10016914364
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500197
[Journal Article] Orexinergic projections to the midbrain mediate alternation of behavioral states from locomotion to cataplexy.2005
- Author(s)
  Takakusaki K, Takahashi K, Saitoh K, Harada H, Okumura T, Koyama Y, Kayama Y.
- Journal Title
  
  J Physiol 568
  
  Pages: 1003-1020
- Data Source
  KAKENHI-PROJECT-17075002
[Journal Article] Intracisternal injection of orexin-A prevents ethanol-induced gastric mucosal damage in rats.
- Author(s)
  Yamada H, Tanno S, Takakusaki K, Okumura T.
- Journal Title
  
  J Gastroenterol (in press)
- NAID
  10019482959
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500197
[Journal Article] Activation of p38 Mitogen-Activated Protein Kinase is Necessary for Gemcitabine-Induced Cytotoxicity in Human Pancreatic Cancer Cells.
- Author(s)
  Koizumi K, Tanno S, Nakano Y, Habiro A, Izawa T, Mizukami Y, Okumura T, Kohgo Y.
- Journal Title
  
  Anticancer Res 25
  
  Pages: 3347-53
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17500197
[Presentation] Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor2017
- Author(s)
  T. Nozu, T. Okumura
- Organizer
  ANMA & JSNM Joint Meeting 2017
- Place of Presentation
  大阪
- Year and Date
  2017-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460287
[Presentation] Water avoidance stress induces visceral hyposensitivity through peripheral corticotropin releasing factor receptor type 2 and central dopamine D2 receptor in rats2017
- Author(s)
  T. Nozu, T. Okumura
- Organizer
  ANMA & JSNM Joint Meeting 2017
- Place of Presentation
  大阪
- Year and Date
  2017-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460287
[Presentation] 消化管運動と内臓知覚における末梢CRF受容体サブタイプの役割－balance theoryについて2015
- Author(s)
  野津　司，奥村　利勝
- Organizer
  日本神経消化器病学会
- Place of Presentation
  沖縄
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26460287
[Presentation] 末梢CRFと胃運動-FDの病態生理との関連について2013
- Author(s)
  野津司,奥村利勝
- Organizer
  日本消化器病学会ワークショップ12機能性ディスペプシア-診断と治療の現況を巡って-
- Place of Presentation
  東京
- Year and Date
  2013-10-11
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] 基底核-脳幹投射系による歩行と筋緊張の制御　=運動細胞内記録の成績=2013
- Author(s)
  高草木薫，野津司，奥村利勝
- Organizer
  第93回生理学会北海道地方会
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-25290001
[Presentation] Inhibition of corticotropin releasing factor (CRF) receptor type 2 signaling enhances peripheral CRF-induced stimulation of colonic contractions in conscious rats2013
- Author(s)
  Tsukasa Nozu, Toshikatsu Okumura
- Organizer
  米国消化器病学会
- Place of Presentation
  Orlando, Fla, USA
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] Modulation of the excitability of hindlimb motoneurons by the basal ganglia efferents to the brainstem in relation to the control of postural muscle tone and locomotion in the decerebrate cat2013
- Author(s)
  Takakusaki K, Nozu T, Okumura T
- Organizer
  Society for Neuroscience 2013
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-25290001
[Presentation] Inhibition of corticotropin releasing factor (CRF) receptor type 2 signaling enhances peripheral CRF-induced stimulation of colonic contractions in conscious rats2013
- Author(s)
  Tsukasa Nozu, Toshikatsu Okumura
- Organizer
  Digestive Disease Week
- Place of Presentation
  Orlando, Fla, USA
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] オレキシンと消化管運動2012
- Author(s)
  野津司,奥村利勝
- Organizer
  日本消化器病学会
- Place of Presentation
  神戸
- Year and Date
  2012-10-10
- Data Source
  KAKENHI-PROJECT-23590252
[Presentation] Spinal interneuronal organization involved in the control of postural muscle tone in the cat
- Author(s)
  Takakusaki K, Chiba R, Obara K, Nozu T, Okumura T.
- Organizer
  Society for Neuroscience Annual Meeting (SFN 2014)
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25290001
[Presentation] Peripheral corticotropin-releasing factor (CRF) induces stimulation of colonic contractions and visceral hyperalgesia in rats; role of CRF receptor type 1 and 2
- Author(s)
  Tsukasa Nozu, Toshikatsu Okumura
- Organizer
  Japan Digestive Disease Week 2014
- Place of Presentation
  神戸
- Year and Date
  2014-10-23 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-26460287
[Presentation] 末梢CRFと胃運動－FDの病態生理との関連について
- Author(s)
  野津　司，奥村利勝
- Organizer
  日本消化器病学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590252

1. NOZU Tsukasa (30312367)

# of Collaborated Projects: 11 results

# of Collaborated Products: 66 results
2. TAKAKUSAKI Kaoru (10206732)

# of Collaborated Projects: 8 results

# of Collaborated Products: 57 results
3. TANNO Satoshi (30333686)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. TAKAHASHI Nobuhiko (20372279)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. TOMITA Nozomi (00375156)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MATSUYAMA Kiyoji (40209664)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KOYAMA Yoshimasa (80183812)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
8. OHHIRA Masumi (30447106)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. KUMEI Shima (00548969)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
10. MORI Futoshi (50301726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YANAGIHARA Dai (90252725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKAJIMA Katsumi (60270485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. INASE Masahiko (80249961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOSHIMI Kenji (40450316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAKAZATO Taizo (80155697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KITAZAWA Shigeru (00251231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. BANDOH Yoshio (20344575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YOSHIDA Shigetaka (20230740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YANO Masafum (80119635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SAITO Hiroyuki (20311532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. YOKOTA Kinnichi (10250573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KOHGO Yutaka (10133183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ASHIDA Toshifumi (50261409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. AYABE Tokiyuoshi (90301019)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. FUJIMOTO Yoshinori (90292127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KASHIWAYANAGI Makoto (20169436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. OBARA Kazuhiro (40548749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
28. FUNAKOSHI Hiroshi (40273685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. KOBAYASHI Kazuto (90211903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 吉見建二 (40459136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 吉崎隆之 (70515189)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 吉崎由美子 (80452936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 斉藤和也 (20301997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 石王応知 (50869211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. Miyagishi Saori

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
36. 斎藤和也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
37. 進藤基博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okumura Toshikatsu 奥村 利勝

OKUMURA Toshikatsu 奥村 利勝

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中枢神経系を介した敗血症死阻止メカニズムの解明 -Ghrelinの関与ーPrincipal Investigator

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Central mechanism of visceral sensation with special reference to brain orexin and its clinical application for irritable bowel syndromePrincipal Investigator

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Role of brain orexin in the pathogenesis of irritable bowel syndromePrincipal Investigator

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Anti-tumor action by PPARgamma ligands in pancreatic cancer: analysis of angigenesis-related genes expressionPrincipal Investigator

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中枢性迷走神経刺激による肝臓で発現する遺伝子発現変化の網羅的解析Principal Investigator

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Okumura Toshikatsu 奥村利勝

OKUMURA Toshikatsu 奥村利勝

中枢神経系を介した敗血症死阻止メカニズムの解明　-Ghrelinの関与ーPrincipal Investigator