Sasaki Ryogen 佐々木良元

… Alternative Names

佐々木良元ササキリヨウゲン

SASAKI Ryogen 佐々木良元

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Researcher Number	60303723
Affiliation (Current)	2025: 鈴鹿医療科学大学, 看護学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 鈴鹿医療科学大学, 看護学部, 教授 2020: 三重大学, 医学部, 寄附講座教授 2018 – 2019: 三重大学, 医学部, 教授 2008: 三重大学, 医学部神経内科, 助教 2008: 三重大学医学部, 神経内科学, 助教 2007: 三重大学, 大学院・医学系研究科, 助教 1998 – 2003: 三重大学, 医学部, 助手
Review Section/Research Field	Except Principal Investigator Neurology / Medium-sized Section 52:General internal medicine and related fields / Basic Section 52020:Neurology-related / Neurology
Keywords	Except Principal Investigator 筋萎縮性側索硬化症 / 紀伊半島 / タウ蛋白 / 神経難病 / グアム島 / タウオパチー / タウ遺伝子 / 痴呆 / パーキンソニズム / パーキンソン痴呆複合 … More / neurofibrillary tangle / parkinsonism-dementia complex / 神経原線維変化 / パーキンソン症候群 / 認知症 / TDP-43 / パーキンソン認知症複合 / パプア / メタゲノム / レジストリ / プロテオミクス / 腸内細菌叢 / エピゲノミクス / 遺伝子解析 / フィールド調査 / 疾患概念 / 病理診断 / 疫学研究 / 家族性発症 / α-シヌクレイノパチー / TDP-43プロテイノパチー / 神経病理学 / 家族歴 / パーキンソン・認知症複合 / Guam island / Kii peninsula / tauopathy / amyotrophic lateral sclerosis / epidemiology / apolipoprotein E polymorphism / SOD1 gene / tau gene / kii peninsula / Amyotrophic lateral sclerosis / パーキンソニズム痴呆複合 / アポリポ蛋白E遺伝子多型 / SOD1遺伝子 / 酸化ストレス / アルツハイマー神経原線維変化 / 遺伝子 / パーキンソン痴呆 / 環境要因 / 遺伝素因 Less

Defining the concept of ALS/parkinsonism-dementia complex of Kii peninsula on the basis of pathologically-verified cases
- Principal Investigator
  
  葛原茂樹
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Suzuka University of Medical Science
ALS/PDC - 世界3大多発地での環境と遺伝子の cross talk -
- Principal Investigator
  
  小久保康昌
- Project Period (FY)
  2018 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Mie University
Molecular biological study on the cause and pathogenesis of amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan
- Principal Investigator
  
  KUZUHARA Shigeki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  National Center of Neurology and Psychiatry
  Mie University
Clinical, cell biological and molecular biological research of ALS/parkinsonism-dementia complex of the Kii peninsula of Japan
- Principal Investigator
  
  KUZUHARRA Shigeki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  MIe University
紀伊半島の家族性神経難病の臨床病理学的研究と原因遺伝子連鎖解析
- Principal Investigator
  
  葛原茂樹
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Mie University
紀伊半島の神経難病多発地域住民の遺伝素因と環境要因の解析
- Principal Investigator
  
  葛原茂樹
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Mie University
紀伊半島の神経難病多発地域住民の遺伝素因と環境要因の解析
- Principal Investigator
  
  KUZUHARA Shigeki
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Mie University
Epidemiological, clinicopathological and molecular genetic : study on amyotrophic lateral sclerosis / parkinsonism-dementia complex of the kii peninsula of Japan (kii ALS/PDC)
- Principal Investigator
  
  KUZUHARA Shigeki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Mie University

All 2023 2022 2021 2020 2019 2018 2008 2007 2003 2001 Other

All Journal Article Presentation

[Journal Article] Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia (ALS/PDC) adopt the CTE Fold.2023
- Author(s)
  Chao Qi, Bert M Verheijen, Yasumasa Kokubo, Yang Shi, Stephan Tetter, Alexey G. Murzin, Asa Nakahara, Satoru Morimoto, Marc Vermulst, Ryogen Sasaki, Eleonora Aronica, Yoshifumi Hirokawa, Kiyomitsu Oyanagi, Akiyoshi Kakita, Benjamin Ryskeldi-Falcon, Mari Yoshida, Masato Hasegawa, Sjors H W Scheres, Michel Goedert.
- Journal Title
  
  PNAS
  
  Volume: 120 Issue: 51
- DOI
  10.1073/pnas.2306767120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-23H00434
[Journal Article] Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula2023
- Author(s)
  Kobayashi Hiroya、Ueda Koji、Morimoto Satoru、Ishikawa Mitsuru、Leventoux Nicolas、Sasaki Ryogen、Hirokawa Yoshifumi、Kokubo Yasumasa、Okano Hideyuki
- Journal Title
  
  Neurological Sciences
  
  Volume: 44 Issue: 12 Pages: 4511-4516
- DOI
  10.1007/s10072-023-07000-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15736, KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-18K07368, KAKENHI-PLANNED-21H05278, KAKENHI-PROJECT-20H00485
[Journal Article] APOE alleles with tau and A pathology in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex in Kii peninsula2022
- Author(s)
  Ryogen Sasaki, Satoru Morimoto, Fumiko Ozawa, Hideyuki Okano, Mari Yoshida, Hiroyuki Ishiura, Shoji Tsuji, Shigeki Kuzuhara, and Yasumasa Kokubo
- Journal Title
  
  Neurology
  
  Volume: 99 Issue: 22
- DOI
  10.1212/wnl.0000000000201156
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-22H04923
[Journal Article] An immigrant family with Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex2021
- Author(s)
  Kokubo Y, Morimoto S, Sasaki R, Hasegawa M, Ishiura H, Tsuji S, Yoshida M, Yamazoe N, Miyazaki M, Kuzuhara S.
- Journal Title
  
  Neurol Sci.
  
  Volume: 43(2) Issue: 2 Pages: 1423-1425
- DOI
  10.1007/s10072-021-05737-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01689, KAKENHI-PROJECT-20H03588, KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-16H06277
[Journal Article] Expression of mutant ubiquitin and proteostasis impairment in Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex brains2020
- Author(s)
  Bert M. Verheijen, Satoru Morimoto, Ryogen Sasaki, Kiyomitsu Oyanagi, Yasumasa Kokubo, Shigeki Kuzuhara, Fred W. van Leeuwen
- Journal Title
  
  J Neuropathol Exp Neurol
  
  Volume: 79 Issue: 8 Pages: 902-907
- DOI
  10.1093/jnen/nlaa056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07368, KAKENHI-PROJECT-18K07514, KAKENHI-PROJECT-19K07820, KAKENHI-PROJECT-18KK0239, KAKENHI-PROJECT-17H01689
[Journal Article] Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan2008
- Author(s)
  Tomiyama H, Kokubo Y, Sasaki R, Li Y, Imamichi Y, Funayama M, Mizuno Y, Hattori N, Kuzuhara S
- Journal Title
  
  Mov Disord 23
  
  Pages: 2344-2348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390239
[Journal Article] Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan.2008
- Author(s)
  Tomiyama H, Kokubo Y, Sasaki R, Li Y, Imamichi Y, Funayama M, Mizuno Y, Hattori N, Kuzuhara S
- Journal Title
  
  Mov Disord 23
  
  Pages: 2344-2348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390239
[Journal Article] 第48回日本神経学会総会シンポジウム西大西洋地域の筋萎縮性側索硬化症/パーキンソン・認知症複合(ALS/PDC)と関連神経変性疾患.紀伊ALS/PDCの分子遺伝学的.2007
- Author(s)
  原賢寿、桑野良三、宮下哲典、小久保康昌、佐々木良元、中原安雄、後藤順、西澤正豊、葛原茂樹、辻省次
- Journal Title
  
  臨床神経 47
  
  Pages: 974-976
- Data Source
  KAKENHI-PROJECT-19390239
[Journal Article] Biochemical and ultrastructural study on neurofibrillary tangles of ALS/PDC cases in the Kii peninsula of Japan.2003
- Author(s)
  Noburo Ito, Koichi Ishiguro, Hiroyuki Arai, Yasumasa Kokubo, Ryogen Sasaki, Yugo Narita, Shigeki Kuzuhara
- Journal Title
  
  JNEN 62
  
  Pages: 791-798
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13470132
[Journal Article] Somatosensory evoked potential recovery in Kii amyotrophic lateral sclerosis/parkinsonism dementia complex (Kii ALS/PDC).2003
- Author(s)
  Machii K., Ugawa Y., Kokubo Y., Sasaki R., Kuzuhara S.
- Journal Title
  
  Clin Neurophysiol 114
  
  Pages: 564-568
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13470132
[Journal Article] Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan : Clinical and neuropathological study and Tau analysis.2001
- Author(s)
  Shigeki Kuzuhara, Yasumasa Kokubo, Ryogen Sasaki, Yugo Narita, Tadashi Yabana, Masato Hasegawa, Takeshi Iwatsubo
- Journal Title
  
  Ann Neurol 49
  
  Pages: 501-511
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13470132
[Journal Article] TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan
- Author(s)
  Hara K, Kokubo Y, Ishiura H, Fukuda Y, Miyashita A, Kuwano R, Sasaki R, Goto J, Nishizawa M, Kuzuhara S, Tsuji S
- Journal Title
  
  Am J Med Genet Part B (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390239
[Journal Article] TRPM7 is not associated with amyotrophic lateral sclerosis-parkinsonism dementia complex in the Kii peninsula of Japan.
- Author(s)
  Hara K, Kokubo Y, Ishiura H, Fukuda Y, Miyashita A, Kuwano R, Sasaki R, Goto J, Nishizawa M, Kuzuhara S, Tsuji S:
- Journal Title
  
  Am J Med Genet Part B (in press)
  
  Pages: 0-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390239
[Presentation] APOE alleles with tau and Aβ pathology in patients with ALS/PDC in Kii peninsula2022
- Author(s)
  Satoru Morimoto, Ryogen Sasaki, Fumiko Ozawa, Hideyuki Okano, Mari Yoshida, Hiroyuki Ishiura, Shoji Tsuji, Shigeki Kuzuhara, Yasumasa Kokubo
- Organizer
  第41回日本認知症学会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] 紀伊半島の筋萎縮性側索硬化症/パーキンソン認知症複合患者のAPOEε2対立遺伝子はタウ病理と関連する2022
- Author(s)
  森本悟, 佐々木良元,小澤史子, 岡野栄之, 吉田眞理, 石浦浩之, 辻省次, 葛原茂樹, 小久保康昌
- Organizer
  第65回日本脳循環代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Expression of mutant ubiquitin and proteostasis impairment in Kii ALS/PDC2020
- Author(s)
  Yasumasa Kokubo,Bert M. Verheijen, Satoru Morimoto, Ryogen Sasaki,Kiyomitsu Oyanagi, Shigeki Kuzuhara, Fred W. van Leeuwen
- Organizer
  第61回日本神経病理学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Medical manual for Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan2020
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, K Kanai, K Okamoto, T Kihira, S. Kuzuhara
- Organizer
  第61回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Abnormal Accumulation of Citrullinated Proteins of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan.2019
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, S. Kuzuhara, A. Ishigami.
- Organizer
  第13回MDSJ
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Abnormal Accumulation of Citrullinated Proteins of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan.2019
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, S. Kuzuhara, A. Ishigami.
- Organizer
  30th International Symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Abnormal Accumulation of Citrullinated Proteins of Amyotrophic Lateral Sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan2019
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, S. Kuzuhara, A. Ishigami.
- Organizer
  第60回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Abnormal accumulation　of　citrullinated proteins of Kii ALS/PDC2019
- Author(s)
  小久保康昌、森本悟、佐々木良元、葛原茂樹、石神昭人
- Organizer
  第13回パーキンソン病・運動障害疾患コングレス
- Data Source
  KAKENHI-PROJECT-18K07514
[Presentation] A Clinical Manual of Amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) of the Kii peninsula of Japan.2018
- Author(s)
  Y. Kokubo, S. Morimoto, R. Sasaki, K Kanai, K Okamoto, T Kihira, S. Kuzuhara.
- Organizer
  第59回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] Amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Hohara focus of the Kii Peninsula : pathological findings as a multiple proteinopathy.2018
- Author(s)
  Maya Mimuro, Mari Yoshida, Yasushi Iwasaki, Ryogen Sasaki, Shigeki Kuzuhara, Yasumasa Kokubo.
- Organizer
  19th International Congress of Neuropathology
- Data Source
  KAKENHI-PROJECT-18KK0239
[Presentation] the three subtypes in Kii ALS/PDC of the H focus : clinicopathological differences of each subtype.2018
- Author(s)
  Maya Mimuro, Mari Yoshida, Ryogen Sasaki, Keita Sakurai, Masato Hasegawa, Shigeki Kuzuhara, Yasumasa Kokubo.
- Organizer
  第59回日本神経学会総会学術研究会
- Data Source
  KAKENHI-PROJECT-18KK0239

1. KUZUHARA Shigeki (70111383)

# of Collaborated Projects: 8 results

# of Collaborated Products: 22 results
2. NARITA Yugo (50242954)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
3. KOKUBO Yasumasa (60263000)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
4. 森本悟 (00816952)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
5. KUWANO Ryouzou (20111734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. TOMIYAMA Hiroyuki (20515069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. HATTORI Nobutaka (80218510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. TSUJI Syouji (70150612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. HARA Kenjyu (10377195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. MURAYAMA Shigeo (50183653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SAITO Yuuko (60344066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HASEGAWA Nmasato (10251232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IWATSUBO Takeshi (50223409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 伊藤伸朗 (10362344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 三室マヤ (20387814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 奥宮清人 (20253346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. AKATSUKA Naomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Sasaki Ryogen 佐々木 良元

佐々木 良元 ササキ リヨウゲン

SASAKI Ryogen 佐々木 良元

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[Journal Article] Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia (ALS/PDC) adopt the CTE Fold.2023

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[Journal Article] Protein profiling of extracellular vesicles from iPSC-derived astrocytes of patients with ALS/PDC in Kii peninsula2023

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[Journal Article] APOE alleles with tau and A pathology in patients with amyotrophic lateral sclerosis and parkinsonism-dementia complex in Kii peninsula2022

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[Journal Article] An immigrant family with Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex2021

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[Journal Article] Expression of mutant ubiquitin and proteostasis impairment in Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex brains2020

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[Journal Article] Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan2008

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[Journal Article] Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan.2008

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[Journal Article] 第48回日本神経学会総会 シンポジウム 西大西洋地域の筋萎縮性側索硬化症/パーキンソン・認知症複合(ALS/PDC)と関連神経変性疾患.紀伊ALS/PDCの分子遺伝学的.2007

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Sasaki Ryogen 佐々木良元

佐々木良元ササキリヨウゲン

SASAKI Ryogen 佐々木良元

[Journal Article] 第48回日本神経学会総会シンポジウム西大西洋地域の筋萎縮性側索硬化症/パーキンソン・認知症複合(ALS/PDC)と関連神経変性疾患.紀伊ALS/PDCの分子遺伝学的.2007

[Presentation] Abnormal accumulation　of　citrullinated proteins of Kii ALS/PDC2019