Yumiko Motoi 本井ゆみ子

… Alternative Names

本井ゆみ子モトイユミコ

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Researcher Number	60338407
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 特任教授
Affiliation (based on the past Project Information) *help	2025: 順天堂大学, 大学院医学研究科, 特任教授 2022 – 2023: 順天堂大学, 大学院医学研究科, 特任教授 2018 – 2020: 順天堂大学, 医学(系)研究科(研究院), 特任教授 2016: 順天堂大学, 医学(系)研究科(研究院), 先任准教授 2014 – 2015: 順天堂大学, 医学(系)研究科(研究院), 准教授 2004 – 2006: 順天堂大学, 医学部, 助手 2001 – 2002: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / General internal medicine(including psychosomatic medicine) Except Principal Investigator Basic Section 49010:Pathological biochemistry-related / Neurology / Neurology
Keywords	Principal Investigator ストレイン / タウ蛋白 / アルツハイマー病 / グリア細胞 / ApoE / シード依存性凝集 / プリオン / 凝集 / ミクログリア / 伝播 … More / 学習障害 / プリオン様伝播 / レビー小体型認知症 / 皮質基底核変性症 / 非流暢性失語 / 意味性認知症 / 髄液マーカー / 脳血流シンチ / ドパーミントランスポーターシンチグラフィ / 進行性失語症 / 皮質基底核症候群 … More Except Principal Investigator タウオパチー / タウ / 大脳皮質基底核変性症 / パーキンソニズム / 痴呆 / タウ蛋白 / tau-strain / 凝集 / Tauopathy / Tau / N279 / corticobasal degeneration / phosphorylated / tau protein / parkinsonism / frontotemporal dementia / tauopathy / 神経原線維変化 / 異常りん酸化 / 認知症 / 培養細胞 / トランスジェニックマウス / 遺伝子改変動物 / パーキンソン病 / N279K / リン酸化 / 前頭側頭型認知症 / CSF / Tau isoform / Tau gene / Corticobasal degeneration / Progressive supranuclear palsy / Parkinsonism / Dementia / Tau protein / RT-PCR / mRNA / 前頭側頭型痴呆 / 定量的RT-PCR法 / 遺伝子変異 / 髄液 / タウアイソフォーム / タウ遺伝子 / 進行性核上性麻痺 Less

細胞種特異的タウ凝集におよぼすApoE4アイソフォーム分子機序解明と遺伝子治療応用Principal Investigator
- Principal Investigator
  
  本井ゆみ子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Juntendo University
Tauopathyにおける構造多型に着目したtau凝集の特異的阻害法開発
- Principal Investigator
  
  下中翔太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Juntendo University
疾患特異的シード依存性タウ凝集におけるグリア細胞の機序解明と臨床応用Principal Investigator
- Principal Investigator
  
  本井ゆみ子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Juntendo University
Tau propagation mechanism and therapeutic target in Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Yumiko Motoi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Juntendo University
Clinical Analysis of Neurodegenerative Dementia Using Cerebrospinal Fluid BiomarkersPrincipal Investigator
- Principal Investigator
  
  Yumiko Motoi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Juntendo University
Studies on the practical diagnosis and pathomechanism of tauopathy as neurodegenerative disordrs
- Principal Investigator
  
  MORI Hideo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
Investigation of mechanism of tauopathy and application for clinical diagnosis
- Principal Investigator
  
  MORI Hideo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University

All 2024 2023 2022 2021 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] Symptoms and age of prodromal Alzheimer’s disease in Down syndrome: a systematic review and meta-analysis2024
- Author(s)
  Shimizu Eri、Goto-Hirano Keiko、Motoi Yumiko、Arai Masami、Hattori Nobutaka
- Journal Title
  
  Neurological Sciences
  
  Volume: 1 Issue: 6 Pages: 2445-2460
- DOI
  10.1007/s10072-023-07292-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07428, KAKENHI-PROJECT-23K08279
[Journal Article] Selection of lansoprazole from an FDA-approved drug library to inhibit the Alzheimer’s disease seed-dependent formation of tau aggregates2024
- Author(s)
  Imtiaz Ahmed、Shimonaka Shotaro、Uddin Mohammad Nasir、Elahi Montasir、Ishiguro Koichi、Hasegawa Masato、Hattori Nobutaka、Motoi Yumiko
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 16 Pages: 01-15
- DOI
  10.3389/fnagi.2024.1368291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07428, KAKENHI-PROJECT-20K16160
[Journal Article] Free water in gray matter linked to gut microbiota changes with decreased butyrate producers in Alzheimer's disease and mild cognitive impairment2024
- Author(s)
  Yamashiro Kazuo、Takabayashi Kaito、Kamagata Koji、Nishimoto Yuichiro、Togashi Yuka、Yamauchi Yohsuke、Ogaki Kotaro、Li Yuanzhe、Hatano Taku、Motoi Yumiko、Suzuki Michimasa、Miyakawa Koichi、Ishikawa Dai、Aoki Shigeki、Urabe Takao、Hattori Nobutaka
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 193 Pages: 106464-106464
- DOI
  10.1016/j.nbd.2024.106464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07428
[Journal Article] Learning Deficits Accompanied by Microglial Proliferation After the Long-Term Post-Injection of Alzheimer’s Disease Brain Extract in Mouse Brains2021
- Author(s)
  Tetsuo Hayashi, Shotaro Shimonaka, Montasir Elahia, Shin-Ei Matsumoto, Koichi Ishiguro, Masashi Takanashi, Nobutaka Hattori and Yumiko Motoi
- Journal Title
  
  Journal of Alzheimer’s Disease
  
  Volume: 79 Issue: 4 Pages: 1701-1711
- DOI
  10.3233/jad-201002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07456, KAKENHI-PROJECT-17K15606, KAKENHI-PROJECT-20K16160
[Journal Article] Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy2021
- Author(s)
  Mohammad Nasir Uddin , Montasir Elahi, Shotaro Shimonaka, Soichiro Kakuta, Koichi Ishiguro, Yumiko Motoi, Nobutaka Hattori
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 543 Pages: 65-71
- DOI
  10.1016/j.bbrc.2020.12.113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07456, KAKENHI-PROJECT-17K15606, KAKENHI-PROJECT-20K16160
[Journal Article] Age-related effects and gender differences in Japanese healthy controls for [123I]FP^CIT SPECT2017
- Author(s)
  Hideo Yamamoto, Shinichi Arimura, Atsushi Nakanishi, Yasushi Shimo, Yumiko Motoi, Koichi Ishiguro, Koji Murakami, Nobutaka Hattori, Shigeki Aoki
- Journal Title
  
  Ann Nucl Med
  
  Volume: 未定 Issue: 5 Pages: 407-412
- DOI
  10.1007/s12149-017-1168-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460921, KAKENHI-PROJECT-26461869
[Patent] 変異タウ蛋白及びそれをコードする変異遺伝子2022
- Inventor(s)
  下中翔太郎, 本井ゆみ子, 長谷川成人
- Industrial Property Rights Holder
  下中翔太郎, 本井ゆみ子, 長谷川成人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-068086
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-22K07428
[Presentation] タウタンパク質の伝播とその臨床応用2023
- Author(s)
  本井ゆみ子、下中翔太郎, Imtiaz, Mohamad, Mohamad Nasir Uddin, 服部信孝
- Organizer
  日本神経精神薬理学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07428
[Presentation] Tau-strainを区別する人工変異導入tauが持つ凝集阻害効果の検討2023
- Author(s)
  下中翔太郎, 石黒幸一, 本井ゆみ子, 服部信孝
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-22K07428
[Presentation] Screening drug library using seed-dependent cellular tau aggregation for Alzheimer's disease2023
- Author(s)
  Ahmed Imtiaz, Shotaro Shimonaka, Montasir Elahi, Koichi Ishiguro, Yumiko Motoi, Nobutaka Hattori
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-22K07428
[Presentation] アルツハイマー病患者脳を注入されたマウスは長期間飼育により学習記憶障害とミクログリアの増殖を示す2021
- Author(s)
  下中翔太郎, 林徹生, Elahi Montasir, 松本信英, 石黒幸一, 服部信孝, 本井ゆみ子
- Organizer
  第62回日本神経病理学会
- Data Source
  KAKENHI-PROJECT-18K07456
[Presentation] Asparagine residue 368 is involved in Alzheimer’s disease tau strain-specific aggregation2021
- Author(s)
  Shotaro Shimonaka, Montasir Elahi, Shin-Ei Matsumoto, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori, Yumiko Motoi
- Organizer
  第62回日本神経病理学会
- Data Source
  KAKENHI-PROJECT-18K07456
[Presentation] TauのAsn368変異はAlzheimer病由来seedによる凝集のみを低下させる2019
- Author(s)
  下中翔太郎、松本信英、石黒　幸一, 本井ゆみ子、服部信孝
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07456
[Presentation] TauのC末端領域における凝集責任配列の同定とその性質の解析2018
- Author(s)
  下中翔太郎、松本信英、本井ゆみ子、服部信孝
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07456
[Presentation] タウ蛋白伝播モデルマウスにおけるの行動および病組織理学的解析2018
- Author(s)
  林　徹生、下中翔太郎、モンタシル・エラヒ、本井ゆみ子、服部信孝
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-18K07456
[Presentation] Dopamine transporrter scanで顕著な結合低下を示したN279Kタウ変異の前頭側頭葉変性症の5例2016
- Author(s)
  竹重遥香、中山茶千子、林徹生、西岡健弥、波田野琢、本井ゆみ子、服部信孝
- Organizer
  第57回　日本神経学会総会学術総会
- Place of Presentation
  神戸コンベンションセンター、兵庫県
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26460921
[Presentation] Imaging pattern of atypical Parkinsonian syndromes(APS) using SPECT with 123I-labeled dopamine transporter ligands (DaT)2016
- Author(s)
  Atsushi Nakanishi, Fumihiko Tamamoto, Yumiko Motoi, Michimasa Suzuki, Kouji Kamagata, Hideo Yamamoto, Kouji Ohnuki, Shin-ichi Arimuara, Kouji Murakami, Masaaki Hori, Shigeki Aoki
- Organizer
  日本核医学総会
- Place of Presentation
  名古屋国際会議場、愛知県
- Year and Date
  2016-11-03
- Data Source
  KAKENHI-PROJECT-26460921
[Presentation] ドパミントランスポーターシンチグラフィを用いた原発性進行性失語症の臨床解析2015
- Author(s)
  中村亮太，中山茶千子，本井ゆみ子，服部信孝
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟コンベンションセンター
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26460921
[Presentation] アルツハイマー病理をもつ皮質基底核症候群と診断された２症例の脳血流分布と神経病理2015
- Author(s)
  林田有紗，中山茶千子，高梨雅史，本井ゆみ子，服部信孝
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟コンベンションセンター
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26460921
[Presentation] ドパミントランスポーターシンチグラフィを用いた原発性進行性失語症の臨床解析2015
- Author(s)
  中村亮太，中山茶千子，本井ゆみ子，服部信孝
- Organizer
  日本神経学会総会
- Place of Presentation
  新潟市朱鷺メッセ
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-26460921
[Presentation] 運動障害の目立たないPossible DLBのドパミントランスポーターシンチを用いた臨床解析2015
- Author(s)
  林徹生，中山茶千子，本井ゆみ子，服部信孝
- Organizer
  日本神経学会総会
- Place of Presentation
  新潟市朱鷺メッセ
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-26460921

1. SHIMURA Hideki (50286746)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. MORI Hideo (30150634)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KOBAYASHI Tomonori (50266053)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. HATTORI Nobutaka (80218510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. NISHIOKA Kenya (40348933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. YORITAKA Asako (90245720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MACHIDA Yu (90317470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Nakamura Shinishiro (80407296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. MIZUNO Yoshikuni (30049043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TADA Nobuhiro (50338315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 石黒幸一 (50374012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 下中翔太郎 (90778747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yumiko Motoi 本井 ゆみ子

本井 ゆみ子 モトイ ユミコ

Research Projects

Research Products

Co-Researchers

細胞種特異的タウ凝集におよぼすApoE4アイソフォーム分子機序解明と遺伝子治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tauopathyにおける構造多型に着目したtau凝集の特異的阻害法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

疾患特異的シード依存性タウ凝集におけるグリア細胞の機序解明と臨床応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tau propagation mechanism and therapeutic target in Alzheimer's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clinical Analysis of Neurodegenerative Dementia Using Cerebrospinal Fluid BiomarkersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the practical diagnosis and pathomechanism of tauopathy as neurodegenerative disordrs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of mechanism of tauopathy and application for clinical diagnosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Symptoms and age of prodromal Alzheimer’s disease in Down syndrome: a systematic review and meta-analysis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Selection of lansoprazole from an FDA-approved drug library to inhibit the Alzheimer’s disease seed-dependent formation of tau aggregates2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Free water in gray matter linked to gut microbiota changes with decreased butyrate producers in Alzheimer's disease and mild cognitive impairment2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Learning Deficits Accompanied by Microglial Proliferation After the Long-Term Post-Injection of Alzheimer’s Disease Brain Extract in Mouse Brains2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Age-related effects and gender differences in Japanese healthy controls for [123I]FP^CIT SPECT2017

Author(s)

Journal Title

DOI

Data Source

[Patent] 変異タウ蛋白及びそれをコードする変異遺伝子2022

Inventor(s)

Industrial Property Rights Holder

Yumiko Motoi 本井ゆみ子

本井ゆみ子モトイユミコ

[Presentation] TauのAsn368変異はAlzheimer病由来seedによる凝集のみを低下させる2019

[Presentation] 運動障害の目立たないPossible DLBのドパミントランスポーターシンチを用いた臨床解析2015