Yoshinari Kouichi 吉成浩一

… Alternative Names

YOSHINARI Kouichi 吉成浩一

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Researcher Number	60343399
Other IDs	https://orcid.org/0000-0002-2027-2017
Affiliation (Current)	2024: 静岡県立大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 静岡県立大学, 薬学部, 教授 2017: 静岡県立大学, 薬学部, 講師 2016: 静岡県立大学, 大学院薬学系研究科, 教授 2011 – 2012: 東北大学, 薬学研究科(研究院), 准教授 2007 – 2012: Tohoku University, 大学院・薬学研究科, 准教授 … More 2007: Tohoku University, Graduate School of Pharmaceutical Sciences, Lecturer 2006: 東北大学, 大学院薬学研究科, 講師 2002 – 2005: 静岡県立大学, 薬学部, 講師 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Environmental pharmacy / Environmental pharmacy Except Principal Investigator Medical pharmacy / Gastroenterology / Basic Section 47060:Clinical pharmacy-related / Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 56030:Urology-related / Biological pharmacy
Keywords	Principal Investigator 核内受容体 / 転写調節 / 肝臓 / CAR / 薬物代謝酵素 / 化学物質 / PXR / 炎症 / 肝非実質細胞 / 薬剤性肝障害 … More / 肝毒性 / 安全性学 / 医薬品情報 / レポーターアッセイ / エネルギー代謝 / 糖尿病 / 肝 / 酵素誘導 / 次世代影響 / 発達毒性 / 新生仔 / 遺伝子発現 / 成長障害 / 甲状腺ホルモン / 種差 / 肝再生 / 肝細胞 / 細胞増殖 / 分子間相互作用 / 抗炎症 / 医薬品副作用 / 肝がん / 化学発がん / 肝細胞増殖 / マクロファージ / 炎症シグナル / 肝発がん / 脂質代謝 / 細胞周期 / 動物試験代替法 / マウス / コレステロール / HNF4 / SREBP / DHCR24 / コレステロール合成酵素 / 薬物代謝学 / 芳香族炭化水素受容体 / 脂溶性化学物質 / チトクロムP450 / 定量的PCR / 異物代謝 / CYP1A1 / βナフトフラボン / 脂溶性化合物 / Ah受容体 / 白色脂肪組織 / モデル動物 / 肥満 / CYP3A / チトクロームP450 … More Except Principal Investigator CAR / 核内受容体 / PXR / cytochrome P450 / 薬物代謝酵素 / UGT1A1 / 核内レセプター / 肝星細胞 / Nuclear receptor / Y27632 / Y24180 / グルクロン酸抱合酵素 / 肝臓 / CYP3A4 / 脂質代謝 / Cytochrome P450 / 非アルコール性脂肪性肝炎 / 抗菌薬 / 腸内細菌 / FXR / 胆汁酸 / コレステロール / 治療薬 / 線維化 / 肝硬変 / HSD17B4 / 上皮間葉転換 / 肝がん / リン酸化核内受容体 / 前立腺癌 / アンドロゲン受容体 / がん / MAPKシグナル伝達経路 / プロテオスタシス / がん原遺伝子 / 発生異常 / がん遺伝子産物 / 発がん抑制 / RASopathies / CUL3 / BTB-Kelchファミリー / プロテアソーム / ユビキチン修飾 / ヌーナン症候群 / MAPK / RAS / がん遺伝子 / ヒト腸管 / PPARγ / 臓器差 / 酵素誘導 / 腸管 / 個人差 / 分子記述子 / P450 / DILI評価系 / インビトロDILI 評価系 / インビトロ評価系 / DILI / 薬剤性肝障害 / DSS腸炎 / 炎症性サイトカイン / ＤＳＳ腸炎 / ＣＡＲ / ＰＸＲ / 炎症性腸疾患 / 肝再生 / 肝前駆細胞 / オーバル細胞増殖 / 核内受容体CAR / グルココルチコイド受容体 / エピジェネティクス / 発現調節因子 / 発現制御 / CYP3A7 / SULT1E1 / 糖質コルチコイド / ヒト胎児肝細胞 / Non alcoholic steatohepatitis / 非アルコール性脂防性肝炎 / Growth factor / Transcriptional cofactor / Drug-metabolizing enzyme / Cell cycle / CYP2B6 / コファクター / A1 / グルクロン酸抱合酵素UGT / constitutive androstane receptor(CAR) / 増殖因子 / 転写コファクター / 細胞周期 / cell signalling / Platelet disaggregation / Guanylate cyclase / PAF receptor / Platelet activating factor (PAF) / Platelet / シグナル伝達 / 血小板活性化因子 / PAF / Rho kinase阻害剤 / cGMP / 脱凝集 / 血小板脱凝集反応 / 細胞内情報伝達 / PAF脱凝集反応 / グアニルシクラーゼ / PAF受容体 / 血小板活性化因子(PAF) / 血小板 / flavonoids / nuclear receptor / single nucleotide polymorphism(SNP) / bilirubin / hyperbilirubinemia / Gilbert's syndrome / bilirubin LIDP-glucuronosyltransferase(UGT1A1) / プロモーター遺伝子 / フラボノイド / SNP / 遺伝子変異 / ビリルビン / 高ビリルビン血症 / 体質性黄疸 / 発がん性試験 / PPARα / レポーターアッセイ / 細胞増殖 / 肝化学発がん / 転写調節 / アデノウイルス / オキシステロール / CYP3A11 / 19 / FGF15 / CD36 / トリグリセリド / FGF15/19 / Ctochrome P450 / 肝線維化 / 発現調節 / 消化管吸収 / アンピシリン / 二次胆汁酸 / 回腸胆汁酸吸収 / ASBT / グルタチオン / ME3738 / probucol / 脂質 / マイクロアレイ / xanthine oxidase / flutamide / lithocholic acid / トキシコゲノミクス / 肝障害 / リトコール酸 / フルタミド Less

Development of a Treatment Strategy for Hepatocellular CarcinomaThorough Nuclear Receptor PXR-Mediated Inhibition of Epithelial-Mesenchymal Transition
- Principal Investigator
  
  志津怜太
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Shizuoka
前立腺癌の去勢抵抗性獲得メカニズムとリン酸化核内受容体の病態解明
- Principal Investigator
  
  柿崎暁
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  独立行政法人国立病院機構高崎総合医療センター(臨床研究部)
HSD17B4の新機能に着目した肝硬変治療薬の開発
- Principal Investigator
  
  松原勤
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University
Elucidation of molecular mechanisms of RAS degradation and understanding of LZTR1-related molecular networks
- Principal Investigator
  
  Abe Taiki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tohoku University
Investigation of the next-generation and late-onset effects of drugs focusing on liver maturation and liver function regulated by the nuclear receptors PXR and CARPrincipal Investigator
- Principal Investigator
  
  Yoshinari Kouichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Shizuoka
Elucidation of the molecular mechanism of CYP3A4 induction in the human intestine and its differences from the liver
- Principal Investigator
  
  Hosaka Takuomi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Shizuoka
Nuclear receptor PXR-mediated hepatocyte proliferation: understanding of its mechanism and human relevancePrincipal Investigator
- Principal Investigator
  
  Yoshinari Kouichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Development of evaluation methods for drug-induced liver injury based on both chemical structure/biological reactivity of drugs and individual factors
- Principal Investigator
  
  Sasaki Takamitsu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
Elucidation of mechanisms underlying different glucocorticoid responses of drug-metabolizing enzymes, SULT1E1 and CYP3A7, in human fetal liver cells
- Principal Investigator
  
  OHMORI Shigeru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Shinshu University
The role of nuclear receptors PXR/CAR in the pathogenesis of inflammatory bowel diseases.
- Principal Investigator
  
  Kakizaki Satoru
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gunma University
化学物質のヒトでの安全性評価のための核内受容体CARを介した肝発がん機構の解明
- Principal Investigator
  
  山添康
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
The role of nuclear receptor CAR in the liver regeneration and repair madiated by oval cell proliferation.
- Principal Investigator
  
  Yamazaki Yuichi
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gunma University
Understanding of molecular mechanism and development of prediction system of drug- induced hepatotoxicity, focusing on the inflammation-associated nuclear receptors and cell-cell interactions.Principal Investigator
- Principal Investigator
  
  YOSHINARI Kouichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Understanding of the mechanism for the nuclear receptor-mediated hepatotoxicity and establishment of the prediction and evaluation system for the toxicity.Principal Investigator
- Principal Investigator
  
  YOSHINARI Kouichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
CYP3A4 induction-associated dyslipidemia : a new risk factor for lifestyle disease
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Regulation of hepatic lipid metabolism through ileal bile acid-FGF signaling
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Role of ileal bile acid absorption on regulation of serum cholesterol levels
- Principal Investigator
  
  MIYATA Masaaki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
The role and crosstalk between nuclear receptors PXR and CAR on the pathogenesis of non-alcoholic steatohepatitis.
- Principal Investigator
  
  KAKIZAKI Satoru
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gunma University
Mechanisms for delayed organ toxicity induced by drug and prediction system using comprehensive analysis
- Principal Investigator
  
  YAMAZOE Yasushi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Role of nuclear receptors PXR and CAR under the energy surplus condition such as obesityPrincipal Investigator
- Principal Investigator
  
  YOSHINARI Kouichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
The role of nuclear receptor CAR in the pathogenesis of non-alcoholic Steatohepatitis
- Principal Investigator
  
  KAKIZAKI Satoru
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Gunma University
新規な肥満・糖尿病制御要因:外来異物による脂肪組織Ah受容体活性化機構の研究Principal Investigator
- Principal Investigator
  
  吉成浩一
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Shizuoka
Induction of CAR and the nuclear localization are promoted in HepG2 hepatoma cells arrested at G_1 phase of cell cycle : Association with gene expression of UGT1A1 and Gadd45β
- Principal Investigator
  
  SUGATANI Junko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
Guanylate cyclase-cyclic GMP signaling pathway in platelet disaggregation associated with dissociation of PAF-receptor complex
- Principal Investigator
  
  MIWA Masao
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
肝薬物代謝酵素レベルに影響を及ぼす核内受容体CAR遺伝子の発現制御機序の解明Principal Investigator
- Principal Investigator
  
  吉成浩一
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  University of Shizuoka
Study on defect in human UGTIAI gene promoter associated with hyperbilirubinemia and mechanism of the UGTIAI in duction
- Principal Investigator
  
  SUGATANI Junko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka

[Journal Article] PPARα Induces the Expression of CAR That Works as a Negative Regulator of PPARα Functions in Mouse Livers2023
- Author(s)
  Ryota Shizu, Yuta Otsuka, Chizuru Ishii, Kanako Ezaki, Kouichi Yoshinari
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 4 Pages: 3953-3953
- DOI
  10.3390/ijms24043953
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07202, KAKENHI-PROJECT-21K15317
[Journal Article] Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development2022
- Author(s)
  Kouichi Yoshinari, Ryota Shizu
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 50 Issue: 7 Pages: 1019-1026
- DOI
  10.1124/dmd.121.000481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07202
[Journal Article] The influence of the long‐term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice2021
- Author(s)
  Ryota Shizu, Mai Ishimura, Sumihito Nobusawa, Takuomi Hosaka, Takamitsu Sasaki, Satoru Kakizaki, Kouichi Yoshinari
- Journal Title
  
  Archives of Toxicology
  
  Volume: 95 Issue: 3 Pages: 1089-1102
- DOI
  10.1007/s00204-020-02955-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07202, KAKENHI-PROJECT-17K08387, KAKENHI-PROJECT-19K16352
[Journal Article] PXR suppresses PPARα-dependent HMGCS2 gene transcription by inhibiting the interaction between PPARα and PGC1α2021
- Author(s)
  R. Shizu, K. Ezaki, T. Sato, A. Sugawara, T. Hosaka, T. Sasaki, K. Yoshinari
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 12 Pages: 3550-3550
- DOI
  10.3390/cells10123550
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07202, KAKENHI-PROJECT-21K15317
[Journal Article] Antiepileptic Drug?Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator?Activated Receptorαand Peroxisome Proliferator?Activated ReceptorγCoactivator 1α?Dependent Gene Expression to Increase Blood Triglyceride Levels2020
- Author(s)
  Shizu Ryota、Otsuka Yuta、Ezaki Kanako、Ishii Chizuru、Arakawa Shingo、Amaike Yuto、Abe Taiki、Hosaka Takuomi、Sasaki Takamitsu、Kanno Yuichiro、Miyata Masaaki、Yamazoe Yasushi、Yoshinari Kouichi
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 98 Issue: 5 Pages: 634-647
- DOI
  10.1124/molpharm.120.000103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07090, KAKENHI-PROJECT-20K07202
[Journal Article] Nuclear receptor CAR-mediated liver cancer and its species differences2020
- Author(s)
  Shizu Ryota、Yoshinari Kouichi
- Journal Title
  
  Expert Opinion on Drug Metabolism & Toxicology
  
  Volume: 16 Issue: 4 Pages: 343-351
- DOI
  10.1080/17425255.2020.1746268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08418, KAKENHI-PROJECT-20K07202, KAKENHI-PROJECT-19K16352
[Journal Article] PXR functionally interacts with NF-κB and AP-1 to downregulate the inflammation-induced expression of chemokine CXCL2 in mice.2020
- Author(s)
  Maya Okamura, Ryota Shizu, Taiki Abe, Susumu Kodama, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 10 Pages: 2520-2520
- DOI
  10.3390/cells9102296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07202
[Journal Article] Role of Nuclear Receptors PXR and CAR in Xenobiotic-Induced Hepatocyte Proliferation and Chemical Carcinogenesis2019
- Author(s)
  Yoshinari Kouichi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 8 Pages: 1243-1252
- DOI
  10.1248/bpb.b19-00267
- NAID
  130007686697
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-08-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08418
[Journal Article] Functional interaction between PXR and YAP in xenobiotic-dependent liver hypertrophy and drug metabolism.2019
- Author(s)
  Abe, T., Shizu, R., Sasaki, T., Shimizu, Y., Hosaka, T., Kodama, S., Matsuzawa, A., Yoshinari, K.
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: 371 Issue: 3 Pages: 590-601
- DOI
  10.1124/jpet.119.258632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-17K08418
[Journal Article] Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in?vitro2019
- Author(s)
  Okamura Maya、Shizu Ryota、Hosaka Takuomi、Sasaki Takamitsu、Yoshinari Kouichi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 34 Issue: 4 Pages: 272-279
- DOI
  10.1016/j.dmpk.2019.04.005
- NAID
  50014558515
- Data Source
  KAKENHI-PROJECT-17K08418
[Journal Article] Discriminative models using molecular descriptors for predicting increased serum ALT levels in repeated-dose toxicity studies of rats2018
- Author(s)
  Takeshita Jun-ichi、Nakayama Haruka、Kitsunai Yoko、Tanabe Misako、Oki Hitomi、Sasaki Takamitsu、Yoshinari Kouichi
- Journal Title
  
  Computational Toxicology
  
  Volume: 6 Pages: 64-70
- DOI
  10.1016/j.comtox.2017.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08419, KAKENHI-PROJECT-16K21674
[Journal Article] Screening of Industrial and Agricultural Chemicals for Searching a Mouse PXR Activator Using Cell-Based Reporter Gene Assays2018
- Author(s)
  Ryota Shizu, Makoto Kano, Taiki Abe, Saki Tsuchiya, Yuki Shimizu, Michiko Watanabe, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Journal Title
  
  BPB Reports
  
  Volume: 1 Pages: 11-19
- NAID
  130007938427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08418
[Journal Article] Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR2018
- Author(s)
  Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasak, Kouichi Yoshinari
- Journal Title
  
  J Toxicol Sci
  
  Volume: 印刷中
- NAID
  50014469406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08418
[Journal Article] Effect of health foods on cytochrome P450-mediated drug metabolism2017
- Author(s)
  Sasaki Takamitsu、Sato Yu、Kumagai Takeshi、Yoshinari Kouichi、Nagata Kiyoshi
- Journal Title
  
  Journal of Pharmaceutical Health Care and Sciences
  
  Volume: 3 Issue: 1 Pages: 14-14
- DOI
  10.1186/s40780-017-0083-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08419
[Journal Article] Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.2013
- Author(s)
  Ryota Shizu, Satoshi Benoki, Yuki Numakura, Susumu Kodama, Masaaki Miyata, Yasushi Yamazoe, Kouichi Yoshinari
- Journal Title
  
  PLOS ONE
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390027
[Journal Article] Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor -α (PPARα) is enhanced by pregnane X receptor (PXR) sctivation in mice2013
- Author(s)
  Shizu R, Benoki S, Numakura Y, SusumuKodama S, Miyata M, Yamazoe Y, Yoshinari K
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 4 Pages: e61802-e61802
- DOI
  10.1371/journal.pone.0061802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390027
[Journal Article] Novel cell-based reporter assay system using epitope-tagged protein for the identification of agonistic ligands of constitutive androstane receptor (CAR)2013
- Author(s)
  Imai J, Yamazoe Y, Yoshinari K
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: (in press)
- NAID
  130004463318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390027
[Journal Article] Novel cell-based reporter assay system using epitope-tagged protein for the identification of agonistic ligands of constitutive androstane receptor (CAR).2013
- Author(s)
  Imai J, Yamazoe Y, Yoshinari K.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 印刷中
- NAID
  130004463318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390027
[Journal Article] Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two ciselements common to both genes2012
- Author(s)
  Araki K, Watanabe K, Yamazoe Y, Yoshinari K
- Journal Title
  
  Toxicol lett
  
  Volume: 215 Issue: 1 Pages: 16-24
- DOI
  10.1016/j.toxlet.2012.09.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390027
[Journal Article] Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes2012
- Author(s)
  Benoki B, Yoshinari K, Chikada T, Imai J, Yamazoe Y
- Journal Title
  
  ArchBiochem Biophys
  
  Volume: 517 Issue: 2 Pages: 123-130
- DOI
  10.1016/j.abb.2011.10.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390027
[Journal Article] Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme24-dehydrocholesterol reductase2012
- Author(s)
  Yoshinari K, Ohno H, Benoki S, Yamazoe Y
- Journal Title
  
  Toxicoy Lett
  
  Volume: 208 Issue: 2 Pages: 185-191
- DOI
  10.1016/j.toxlet.2011.11.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390027
[Journal Article] Involvement of multiple elements in FXR-mediated transcriptional activation of2012
- Author(s)
  M. Miyata, T. Hata, H. Yamakawa, T. Kagawa, K. Yoshinari, and Y Yamazoe
- Journal Title
  
  FGF19 J Steroid Biochem Mol Biol
- URL
  http://dx.doi.org/10.1016/j.jsbmb
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390039
[Journal Article] Amelioration of disrupted hepatic lipogenesis in Fxr-null mice by human FGF19 treatment2011
- Author(s)
  M Miyata, Y. Sakaida, H. Matsuzawa, K. Yoshinari and Y. Yamazoe
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 34 Pages: 1885-1889
- URL
  http://dx.doi.org/10.1248/bpb.34.1885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390039
[Journal Article] Activated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liver2011
- Author(s)
  Shin-ichi Inoue, Kouichi Yoshinari, Mika Sugawara, Yasushi Yamazoe
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 79巻 Issue: 1 Pages: 148-156
- DOI
  10.1124/mol.110.068577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659028
[Journal Article] Unveiling a new essential cis-element for the transactivation of the CYP3A4 gene by xenobiotics2009
- Author(s)
  T. Toriyabe, K. Nagata, T. Takada, Y. Aratsu, T. Matsubara, K Yoshinari, and Y. Yamazoe
- Journal Title
  
  Mol Pharmacol 75
  
  Pages: 677-684
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] Role of enzymatic N-hydroxylation and reduction in flutamide metabolite-induced liver toxicity2009
- Author(s)
  M. Ohbuchi, M. Miyata, D. Nagai, M. Shimada, K. Yoshinari, and Y. Yamazoe
- Journal Title
  
  Drug Metab Dispos 37
  
  Pages: 97-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] Role of enzymatic N-hydroxylation and reduction in flutamide metabolite-induced livertoxicity2009
- Author(s)
  M. Ohbuchi, M. Miyata, D. Nagai, M. Shimada, K. Yoshinari and Y. Yamazoe
- Journal Title
  
  Drug Matab.Dispos. 37
  
  Pages: 97-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390037
[Journal Article] Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor2009
- Author(s)
  M. Nomoto, M. Miyata, S. Yin, Y. Kurata, M. Shimada, K. Yoshinari, F. J Gonzalez, K. Suzuki, S. Shibasaki, T. Kurosawa,and Y. Yamazoe
- Journal Title
  
  Biol.Pharm.Bull. 32
  
  Pages: 172-178
- NAID
  110007042166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390037
[Journal Article] Role of vitamin D receptor in the lithocholic acid-mediated CYP3A induction in vitro and in vivo2008
- Author(s)
  T. Matsubara, K. Yoshinari, K. Aoyama, M. Sugawara, Y. Sekiya, K. Nagata, and Y. Yamazoe
- Journal Title
  
  Drug Metab Dispos 36
  
  Pages: 2058-2063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] Involvement of ST1B subfamily of cytosolic sulfotransferase in kynurenine metabolism to form natriuretic xanthurenic acid sulfate2008
- Author(s)
  L. Senggunprai, K. Yoshinari, M. Shimada, and Y. Yamazoe
- Journal Title
  
  J Pharmacol Exp Ther 327
  
  Pages: 789-798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] Umeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements2008
- Author(s)
  K. Yoshinari, et.al.
- Journal Title
  
  Biochem Pharmacol 76
  
  Pages: 139-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements2008
- Author(s)
  K. Yoshinari, R. Ueda, K. Kusano, T. Yoshimura, K. Nagata, and Y. Yamazoe
- Journal Title
  
  Biochem Pharmacol 76
  
  Pages: 139-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] Bile acid-induced elevated oxidative stress in the absence of farnesoid X receptor2008
- Author(s)
  M. Nomoto, M. Miyata, S. Yin, Y. Kurata, M. Shimada, K. Yoshinari, F. J. Gonzalez, K. Suzuki, S. Shibasaki, T. Kurosawa, and Y. Yamazoe
- Journal Title
  
  Biol Pharm Bull 32
  
  Pages: 172-178
- NAID
  110007042166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output.2007
- Author(s)
  M Nomoto, M Miyata, M Shimada, K Yoshinari, FJ Gonzalez, S Shibasaki, T Kurosawa, Y Shindo, Y Yamazoe
- Journal Title
  
  European Journal of Pharmacology 574
  
  Pages: 192-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] Role of human hepatocyte nuclear factr 4a in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA.2007
- Author(s)
  Y Kamiyama, T Matsubara, K Yoshinari, K Nagata, H Kamimura, Y Yamazoe
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 22
  
  Pages: 287-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] Assessment of human pregnane X receptor-involvement in pesticide-mediated activation of CYP3A4 gene.2007
- Author(s)
  T Matsubara, W Noracharttiyapot, T Toriyabe, K Yoshinari, K Nagata, Y Yamazoe
- Journal Title
  
  Drug Metabolism and Disposition 35
  
  Pages: 728-733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] ME3738 protects against lithocholic acid-induced hepatotoxicity, associated with enhancemnt in biliary bile acid and cholesterol output2007
- Author(s)
  M. Nomoto, M. Miyata, M Shimada, K. Yoshinari, F. J Gonzalez, S. Shibasaki, T. Kurosawa, Y. Shindo, Y. Yamazoe
- Journal Title
  
  Eur.J.Pharmacol 574
  
  Pages: 192-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390037
[Journal Article] Role of human hepatocyte nuclear factor 4a in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA2007
- Author(s)
  Y. Kamiyama, T. Matsubara, K. Yoshinari, K. Nagata, H. Kamimura, and Y. Yamazoe
- Journal Title
  
  Drug Metab Pharmacokinet 22
  
  Pages: 287-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] ME3738 protects against lithocholic acid-induced hepatotoxicity, which is associated with enhancement of biliary bile acid and cholesterol output2007
- Author(s)
  M. Nomoto, M. Miyata, M. Shimada, K. Yoshinari, F.J. Gonzalez, S. Shibasaki, T. Kurosawa, Y. Shindo, and Y. Yamazoe
- Journal Title
  
  Eur J Pharmacol 574
  
  Pages: 192-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] Assessment of human pregnane X receptor-involvement in pesticide-mediated activation of CYP3A4 gene2007
- Author(s)
  T. Matsubara, W. Noracharttiyapot, T. Toriyabe, K. Yoshinari, K. Nagata, and Y. Yamazoe
- Journal Title
  
  Drug Metab Dispos 35
  
  Pages: 728-733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790114
[Journal Article] Gene expression profiles of drug-metabolizing enzymes and transporters with an overexpression of hepatocyte growth factor2007
- Author(s)
  Kakizaki S, Yamazaki Y, Kosone T, Horiguchi N, Sohara N, Sato K, Takagi H, Yoshinari K, Mori M.
- Journal Title
  
  Liver Int 27
  
  Pages: 109-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590716
[Journal Article] Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet.2006
- Author(s)
  Kouichi Yoshinari, Shunsuke Takagi, Teruyasu Yoshimasa, Junko Sugatani, Masao Miwa
- Journal Title
  
  Pharmaceut. Res. DOI : 10. 1007/s 11095-006-
  
  Pages: 71-76
- NAID
  130004639309
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet.2006
- Author(s)
  Kouichi Yoshinari, et al.
- Journal Title
  
  Pharmaceut.Res.
- NAID
  130004639309
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet.2006
- Author(s)
  Kouichi Yoshinari, et al.
- Journal Title
  
  Pharmaceut.Res.
- NAID
  130004639309
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet.2006
- Author(s)
  Kouichi Yoshinari, Shunsuke Takagi, Teruyasu Yoshimasa, Junko Sugatani, Masao Miwa
- Journal Title
  
  Pharmaceut.Res. DOI : 10. 1007/sl 1095-006-0071-6
- NAID
  130004639309
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Induction of detoxifying enzymes in rodent white adipose tissue by aryl hydrocarbon receptor agonists and antioxidants.2006
- Author(s)
  Kouichi Yoshinari, et al.
- Journal Title
  
  Drug Metab.Dispos.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Induction of detoxifying enzymes in rodent white adipose tissue by aryl hydrocarbon receptor agonists and antioxidants.2006
- Author(s)
  Kouichi Yoshinari, et al.
- Journal Title
  
  Drug Metab.Dispos.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Induction of detoxifying enzymes in rodent white adipose tissue by aryl hydrocarbon receptor agonists and antioxidants.2006
- Author(s)
  Kouichi Yoshinari, Nao Okino, Takeshi Sato, Junko Sugatani, Masao Miwa
- Journal Title
  
  Drug Metab. Dispos. DOI : 10.1124/dmd
  
  Volume: 34 Issue: 7 Pages: 1081-1089
- DOI
  10.1124/dmd.105.007286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063, KAKENHI-PROJECT-16590056
[Journal Article] Transcriptional regulation of human UGT1A1 gene expression : Activated GR enhances CAR/PXR-mediated UGT1A1 regulation with GRIP1.2005
- Author(s)
  Junko Sugatani, Shinichi Nishitani, Kasumi Yamakawa, Kouichi Yoshinari, Tatsuya Sueyoshi, Masahiko Negishi, Masao Miwa
- Journal Title
  
  Mol.Pharmacol. 67(3)
  
  Pages: 845-855
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Transcriptional regulation of human UGT1A1 gene expression : Activated GR enhances CAR/PXR-mediated UGT1A1 regulation with GRIP1.2005
- Author(s)
  Junko Sugatani, Shinichi Nishitani, Kasurni Yamakawa, Kouichi Yoshinari, Tatsuya Sueyoshi, Masahiko Negishi, Masao Miwa
- Journal Title
  
  Mol.Pharmacol. 67(3)
  
  Pages: 845-855
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Expression and induction of cytochromes P450 in rat white adipose tissue.2004
- Author(s)
  Kouichi Yoshinari et al.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 311・1
  
  Pages: 147-154
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Expression and Induction of Cytochromes P450 in Rat White Adipose Tissue.2004
- Author(s)
  Kouichi Yoshinari, et al.
- Journal Title
  
  J.Pharmacol.Exp Ther. 311
  
  Pages: 147-154
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Expression and Induction of Cytochromes P450 in Rat White Adipose Tissue.2004
- Author(s)
  Kouichi Yoshinari, et al.
- Journal Title
  
  J.Pharmacol.Exp Ther. 311
  
  Pages: 147-154
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Tea polyphenols inhibit acetyl-CoA : l-alkyl-sn-glycero-3- phosphocholine acetyltransferase (a key enzyme in PAF biosynthesis) and PAF- induced platelet aggregation.2004
- Author(s)
  Junko Sugatani, Nana Fukazawa, Kenji Ujihara, Kouichi Yoshinari, Ikuo Abe, Hiroshi Noguchi, Masao Miwa
- Journal Title
  
  Intern.Arch.Allergy Immunol. 134
  
  Pages: 17-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Tea polyphenols inhibit acetyl-CoA : 1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in PAF biosynthesis) and PAF-induced platelet aggregation.2004
- Author(s)
  Junko Sugatani, Nana Fukazawa, Kenji Ujihara, Kouichi Yoshinari, Ikuo Abe, Hiroshi Noguchi, Masao Miwa
- Journal Title
  
  Intern.Arch.Allergy Immunol. 134
  
  Pages: 17-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] The induction of human bilirubin UDP-glucuronosyltransferase mediated through a distal enhancer module by flavonoids and xenobiotics.2004
- Author(s)
  Junko Sugatani, Kasumi Yamakawa, Eri Tonda, Shinichi Nishitani, Kouichi Yoshinari, Masakuni Degawa, Ikuro Abe, Hiroshi Noguchi, Masao Miwa
- Journal Title
  
  Biochem. Phalmacol. 67(5)
  
  Pages: 989-1000
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Expression and Induction of Cytochromes P450 in Rat White Adipose Tissue.2004
- Author(s)
  Kouichi Yoshinari, Takeshi Sato, Nao Okino, Junko Sugatani, Masao Miwa
- Journal Title
  
  J.Phalmacol.Exp Ther. 311
  
  Pages: 147-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Expression and induction of cytochromes P450 in rat white adipose tissue.2004
- Author(s)
  吉成浩一, 佐藤健志, 沖野奈央, 菅谷純子, 三輪匡男
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 311(1)
  
  Pages: 147-154
- Data Source
  KAKENHI-PROJECT-16790088
[Journal Article] Expression and Induction of Cytochromes P450 in Rat White Adipose Tissue.2004
- Author(s)
  Kouichi Yoshinari, Takeshi Sato, Nao Okino, Junko Sugatani, Masao Miwa
- Journal Title
  
  J.Pharmacol.Exp Ther. 311
  
  Pages: 147-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Expression and induction of cytochromes P450 in rat white adipose tissue2004
- Author(s)
  Kouichi Yoshinari et al.
- Journal Title
  
  J.Pharmacol.Exp.Ther. 311・1
  
  Pages: 147-154
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Induction of detoxifying enzymes in rodent white adipose tissue by aryl hydrocarbon receptor agonists and antioxidants.
- Author(s)
  Kouichi Yoshinari et al.
- Journal Title
  
  Drug Metab.Dispos., (in press)
- Data Source
  KAKENHI-PROJECT-16590056
[Journal Article] Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet,
- Author(s)
  Kouichi Yoshinari et al.
- Journal Title
  
  Pharmaceut.Res. (in press)
- NAID
  130004639309
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Induction of detoxifying enzymes in rodent white adipose tissue by aryl hydrocarbon receptor agonists and antioxidants.
- Author(s)
  Kouichi Yoshinari et al.
- Journal Title
  
  Drug Metab.Dispos. (in press)
- Data Source
  KAKENHI-PROJECT-15590063
[Journal Article] Hepatic CYP3A expression is attenuated in obese mice fed a high-fat diet,
- Author(s)
  Kouichi Yoshinari et al.
- Journal Title
  
  Pharmaceut.Res., (in press)
- NAID
  130004639309
- Data Source
  KAKENHI-PROJECT-16590056
[Presentation] 化学物質曝露による核内受容体CAR活性化が乳幼児の発達に及ぼす影響2022
- Author(s)
  田代紗莉依、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] 乳幼児期における化学物質曝露はCAR活性化を介して成長遅延を引き起こす2022
- Author(s)
  田代紗莉依、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第68回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] 肝のCYP3A4発現における肝星細胞の役割2021
- Author(s)
  伊豆倉裕翔、保坂卓臣、森田華帆、志津怜太、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] 核内受容体PXRと肝細胞増殖・肝発がん2021
- Author(s)
  吉成浩一
- Organizer
  環境ホルモン学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] 乳幼児期マウスにおける核内受容体CARの活性化が甲状腺ホルモンシグナルに及ぼす影響2021
- Author(s)
  田代紗莉依、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第4回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] ラット反復投与毒性試験データベースを利用した小葉中心性肝細胞肥大の発現機序解析2021
- Author(s)
  柴田尚輝、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  第38回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] 転写因子TFE3を介したヒト肝細胞におけるCYP3A4の転写調節2021
- Author(s)
  保坂卓臣、勝山早苗、志津怜太、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] 乳幼児期における核内受容体CAR活性化の甲状腺ホルモンシグナルに対する影響2021
- Author(s)
  田代紗莉依、志津怜太、保坂卓臣、菅野裕一朗、吉成浩一
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2021
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] ヒト腸管由来LS180細胞でのrosiglitazoneによるCYP3A4誘導機序の解析2021
- Author(s)
  佐々木貴章、保坂卓臣、鶴田聡志、志津怜太、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] ヒト腸管由来細胞でのrosiglitazoneによるCYP3A4誘導機序の解析2020
- Author(s)
  佐々木貴章、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] 化学物質によるPXR活性化のマウス肝発がんへの影響解析2020
- Author(s)
  志津怜太、石村麻衣、信澤純人、保坂卓臣、佐々木崇光、柿崎暁、吉成浩一
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] 化学物質によるPXR活性化のマウス肝発がんへの影響解析2020
- Author(s)
  志津怜太、石村麻衣、信澤純人、保坂卓臣、佐々木崇光、柿崎暁、吉成浩一
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] リガンド依存的なタンパク質構造変化に着目したPXR活性化評価系の構築2020
- Author(s)
  西口輝、志津怜太、保坂卓臣、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2020
- Data Source
  KAKENHI-PROJECT-19K07226
[Presentation] 抗てんかん薬によるCARの活性化はPPARαの抑制を介して血中脂質レベルを増加させる2020
- Author(s)
  志津怜太、江崎香奈子、保坂卓臣、佐々木崇光、菅野裕一朗、吉成浩一
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
- Data Source
  KAKENHI-PROJECT-20K07202
[Presentation] フェノバルビタールによる肝発がんへのPXR活性化の影響2019
- Author(s)
  石村麻衣、志津怜太、曽部圭一郎、江崎香奈子、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] マウスにおける核内受容体PXR活性化薬長期間投与の肝発がんへの影響2019
- Author(s)
  石村麻衣、志津怜太、吉成浩一
- Organizer
  令和元年度内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] Interaction between CAR and YAP is a possible underlying mechanism of phenobarbital-dependent hepatocarcinogenesis and its species difference2019
- Author(s)
  Ryota Shizu, Taiki Abe, Keichiro Sobe, Mai Ishimura, Yuto Amaike, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  Cold Spring Harbor Asia meeting on Liver, Biology, Diseases & Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 化学構造情報とインビトロ試験を利用した肝障害性薬物の判別2019
- Author(s)
  吉成浩一
- Organizer
  安全性評価研究会第28回夏の教育フォーラム
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] CYP3A4誘導：分子機序の理解と創薬における予測2019
- Author(s)
  吉成浩一
- Organizer
  医療薬学フォーラム2019・第27回クリニカルファーマシーシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] The role of YAP in CAR dependent hepatocyte proliferation2019
- Author(s)
  Ryota Shizu, Kouichi Yoshinari
- Organizer
  フォーラム2019衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 化学物質応答性核内受容体 CAR を介した肝発がん2019
- Author(s)
  吉成浩一
- Organizer
  静岡大学グリーン科学技術研究所シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 薬物のシトクロムP450反応性と肝障害誘発性の関連性解析2019
- Author(s)
  米川恵理、山崎弘量、清水佑記、佐々木崇光、渡邉美智子、志津怜太、保坂卓臣、竹下潤一、吉成浩一
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARはPPARα依存的な脂質代謝調節を抑制する2019
- Author(s)
  志津怜太、江崎加奈子、吉成浩一
- Organizer
  令和元年度内外環境応答・代謝酵素研究会
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] Interaction with YAP is a possible underlying mechanism for CAR-dependent hepatocarcinogenesis2019
- Author(s)
  Ryota Shizu, Taiki Abe, Keiichiro Sobe, Mai Ishimura, Takuomi Hosaka, Takamitsu Sasakim Kouichi Yoshinari
- Organizer
  The 12th International Meeting of the International Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 毒性発現機序を考慮したインビトロ試験による化学物質の肝毒性予測2019
- Author(s)
  吉成浩一
- Organizer
  日本動物実験代替法学会第32回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 薬物のシトクロムP450反応性に着目した薬剤性肝障害評価2018
- Author(s)
  米川恵理、清水佑記、佐々木崇光、渡邉美智子、志津怜太、保坂卓臣、竹下潤一、吉成浩一
- Organizer
  平成30年度内外環境応答・代謝酵素研究会（鳥取）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARおよびPXRによる肝細胞増殖調節におけるYAPの関与2018
- Author(s)
  石村麻衣、天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 核内受容体 CAR の活性化が PPARα 依存的な脂質代謝調節に及ぼす影響2018
- Author(s)
  江崎香奈子、志津怜太、大塚祐多、石井千鶴、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Hepatocyte proliferation mediated by nuclear receptor CAR and PXR.2018
- Author(s)
  Kouichi Yoshinari
- Organizer
  2018 International Meeting on 22nd Microsomal Drug Oxidation and 33rd Japanese Society for the Study of Xenobiotics.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 核内受容体CARおよびPXRによる肝細胞増殖調節におけるYAPの関与2018
- Author(s)
  石村麻衣、天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  日本薬学会第138年会（金沢）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] シトクロムP450反応性を利用した肝障害誘発性薬物の判別2018
- Author(s)
  米川恵理、清水佑記、佐々木崇光、渡邉美智子、志津怜太、保坂卓臣、竹下潤一、吉成浩一
- Organizer
  第45回日本毒性学会学術年会（大阪）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Acceleration of murine hepatocyte proliferation by imazaril through the activation of nuclear receptor PXR2018
- Author(s)
  Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  The 22nd North American Meeting of the International Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 遺伝子発現調節機構の解明を基盤とした薬物代謝及び安全性研究2018
- Author(s)
  吉成浩一
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] A possible involvement of transcriptional coactivators in the inflammation-dependent downregulation of PXR-mediated CYP3A induction.2018
- Author(s)
  Maya Okamura, Ryota Shizu, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  2018 International Meeting on 22nd Microsomal Drug Oxidation and 33rd Japanese Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] Imazalil activates the nuclear receptor PXR to accelerate CAR-mediated hepatocyte proliferation in mice.2018
- Author(s)
  Shohei Yoshimaru, Ryota Shizu, Satoshi Tsuruta, Yuto Amaike, Makoto Kano, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari
- Organizer
  The 8th international congress of Asian Society of Toxicology (ASIATOX)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 網羅的な化学物質のシトクロムP450阻害活性評価2018
- Author(s)
  佐々木崇光、渡邉美智子、川野拓歩、猿橋ひとみ、小倉瑠衣、志津怜太、保坂卓臣、吉成浩一
- Organizer
  平成30年度内外環境応答・代謝酵素研究会（鳥取）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] ラットにおける肝化学発がんと核内受容体活性化の関連性2017
- Author(s)
  田部美紗子、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CAR依存的な肝細胞増殖のインビトロ評価系の構築と分子機序の解明2017
- Author(s)
  天池優斗、阿部太紀、保坂卓臣、佐々木崇光、松沢厚、吉成浩一
- Organizer
  第44回日本毒性学会学術年会（横浜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARを介した肝細胞増殖のインビトロ評価系の構築と機序解析2017
- Author(s)
  吉成浩一、阿部太紀、天池優斗、志津怜太、保坂卓臣、佐々木崇光
- Organizer
  第24回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] ラットにおける肝化学発がんと核内受容体活性化の関連性2017
- Author(s)
  田部美紗子、志津怜太、保坂卓臣、鶴田聡志、志津怜太、佐々木崇光、吉成浩一
- Organizer
  平成29年度内外環境応答・代謝酵素研究会（福岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 異物応答性核内受容体による肝細胞増殖制御2017
- Author(s)
  吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Invited
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 肝臓と腸管におけるCYP3A4誘導プロファイルの異同解明2017
- Author(s)
  鶴田聡志、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  第63回日本薬学会東海支部大会（岐阜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 遺伝毒性発がん性と薬物代謝2017
- Author(s)
  吉成浩一
- Organizer
  第44回日本毒性学会学術年会（横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 炎症や疾患に伴う肝薬物代謝酵素の発現変動2017
- Author(s)
  吉成浩一
- Organizer
  日本薬物動態学会第32回年会（東京）
- Invited
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] A possible role of NF-kB in the anti-inflammatory effects of activated PXR2017
- Author(s)
  Maya Okamura, Taiki Abe, Satoshi Tsuruta, Ryota Shizu, Takuomi Hosaka, Takamitsu Sasaki, Susumu Kodama, Kouichi Yoshinari
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 薬剤性肝障害時の核内受容体 PXR の抗炎症作用における NF-κB の役割2017
- Author(s)
  岡村麻絢、阿部太紀、鶴田聡志、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第24回日本免疫毒性学会学術年会（青森）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] CAR utilizes EGF signaling for activation2017
- Author(s)
  Ryota Shizu, Masahiko Negishi, Kouichi Yoshinari
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Influence of food additives on nuclear receptor PXR2017
- Author(s)
  吉丸祥平、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第22回静岡健康・長寿学術フォーラム（静岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] PXRの活性化による抗炎症作用の機序解析2017
- Author(s)
  岡村麻絢、阿部太紀、鶴田聡志、保坂卓臣、佐々木崇光、児玉進、吉成浩一
- Organizer
  第44回日本毒性学会学術年会（横浜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 肝障害誘発性薬物の化学構造的特徴の解析2017
- Author(s)
  清水佑記、佐々木崇光、渡邉美智子、保坂卓臣、竹下潤一、吉成浩一
- Organizer
  第44回日本毒性学会学術年会（横浜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] ヒト肝臓キメラマウス（PXBマウス）を用いたTRAIL-R2/death receptor 5アゴニスト抗体の肝毒性評価及び網羅的遺伝子解析による機序解明2017
- Author(s)
  仁平開人、小野擁子、南谷賢一郎、加国雅和、吉川幸孝、太田紀夫、日浦政則、吉成浩一
- Organizer
  第44回日本毒性学会学術年会（横浜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Characterization of the endocrine disruption potential of bisphenol A structural analogues via human nuclear receptors2017
- Author(s)
  Hiroyuki Kojima, Shinji Takeuchi, Seigo Sanoh, Shigeyuki Kitamura, Naoto Uramaru, Kazumi Sugihara, Kouichi Yoshinari
- Organizer
  The 14th International symposium on persistent toxic substances（名古屋）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Application of cytochrome P450 reactivity assessment to the prediction of livertoxicity of pesticides2017
- Author(s)
  川野拓歩、渡邉美智子、佐々木崇光、隠岐仁美、清水佑記、竹下潤一、志津怜太、保坂卓臣、吉成浩一
- Organizer
  第22回静岡健康・長寿学術フォーラム（静岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Influence of food additives on nuclear receptor PXR2017
- Author(s)
  吉丸祥平、志津怜太、保坂卓臣、佐々木崇光、吉成浩一
- Organizer
  第22回静岡健康・長寿学術フォーラム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] インビトロ及びインシリコ手法による肝毒性の予測評価と毒性データベース2017
- Author(s)
  吉成浩一
- Organizer
  第44回日本毒性学会学術年会（横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] SREBP-2によるCYP3A4の転写制御2017
- Author(s)
  宮嵜靖之、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  日本薬物動態学会第32回年会（東京）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 肝毒性予測を指向したシトクロムP450反応性評価による化学物質プロファイリング2017
- Author(s)
  佐々木崇光、渡邉美智子、清水佑記、櫛田まどか、隠岐仁美、竹下潤一、保坂卓臣、吉成浩一
- Organizer
  第24回HAB研究機構学術年会（東京）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体PXRの抗炎症作用におけるNF-κBの寄与の解析2017
- Author(s)
  岡村麻絢、阿部太紀、鶴田聡志、志津怜太、保坂卓臣、佐々木崇光、児玉進、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] アンドロゲンレセプターの遺伝子一塩基変異のホモ二量体形成への影響2017
- Author(s)
  志津怜太、Su-Jun Lee、根岸正彦、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 異物応答性核内受容体による肝細胞増殖制御2017
- Author(s)
  吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Invited
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] 化学物質のP450反応性と反復投与毒性の関連性2017
- Author(s)
  渡邉美智子、佐々木崇光、清水佑記、櫛田まどか、隠岐仁美、竹下潤一、志津怜太、保坂卓臣、吉成浩一
- Organizer
  第63回日本薬学会東海支部大会（岐阜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CAR依存的な肝細胞増殖へのYAPの関与2017
- Author(s)
  天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、松沢　厚、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] コレステロールレベル調節因子SREBP-2によるCYP3A4の転写制御2017
- Author(s)
  宮嵜靖之、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  第63回日本薬学会東海支部大会（岐阜）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARを介した肝細胞増殖のインビトロ評価系の構築と機序解析2017
- Author(s)
  吉成浩一、阿部太紀、天池優斗、志津怜太、保坂卓臣、佐々木崇光
- Organizer
  第24回肝細胞研究会（旭川）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARおよびPXRによる肝細胞増殖調節におけるYAPの関与2017
- Author(s)
  鶴田聡志、保坂卓臣、志津怜太、佐々木崇光、吉成浩一
- Organizer
  日本薬物動態学会第32回年会（東京）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] Establishment of in silico prediction models for cytochrome P450 inductions in human hepatocytes using azole compounds2017
- Author(s)
  Mika Nagai, Kouichi Yoshinari
- Organizer
  The 21st North American ISSX Meetings（Providence）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] PPARγはヒト腸管由来LS180細胞におけるCYP3A4誘導の新規制御因子である2017
- Author(s)
  保坂卓臣、鶴田聡志、志津怜太、佐々木崇光、吉成浩一
- Organizer
  平成29年度内外環境応答・代謝酵素研究会（福岡）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 薬物代謝及び核内受容体研究を基盤とした化学物質の肝毒性発現機序解明と評価予測系開発2017
- Author(s)
  吉成浩一
- Organizer
  2017年日化協LRI 研究報告会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 薬物代謝及び核内受容体研究を基盤とした化学物質の肝毒性発現機序解明と評価予測系開発2017
- Author(s)
  吉成浩一
- Organizer
  2017年日化協LRI研究報告会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08418
[Presentation] Role of YAP in CAR-mediated proliferation of mouse hepatocytes2017
- Author(s)
  Yuto Amaike, Taiki Abe, Ryota Shizu, Takuomi Hosaka, Takamitsu Sasaki, Atsushi Matsuzawa, Kouichi Yoshinari
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CAR依存的な肝細胞増殖へのYAPの関与2017
- Author(s)
  天池優斗、阿部太紀、志津怜太、保坂卓臣、佐々木崇光、松沢厚、吉成浩一
- Organizer
  フォーラム2017衛生薬学・環境トキシコロジー（仙台）
- Data Source
  KAKENHI-PROJECT-17K08419
[Presentation] 核内受容体CARとPPARαの新規クロストークの機序解明2013
- Author(s)
  大塚祐多、山添康、吉成浩一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] 核内受容体CARの活性化が肝の細胞周期関連遺伝子の発現に与える影響2012
- Author(s)
  辺野喜智、吉成浩一、山添康
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] 核内受容体LXRαによるCYP3A4遺伝子の転写活性化2012
- Author(s)
  櫻井香織、吉成浩一、渡邊圭祐、槌谷友里、山添康
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22659028
[Presentation] PXR活性化薬物の併用はCAR依存的なマウス肝細胞増殖を増強する2012
- Author(s)
  志津怜太、吉成浩一、辺野喜智、山添康
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] 核内受容体CARの活性化が肝の細胞周期関連遺伝子の発現に与える影響2012
- Author(s)
  辺野喜智、吉成浩一、志津怜太、山添康
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] Role of PXR in the xenobiotic induced hepatocyte proliferation.2012
- Author(s)
  志津怜太、吉成浩一、辺野喜智、山添康
- Organizer
  日本癌学会第71回学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] The identification of cell cycle-associated genes regulated by CAR but not PXR.2012
- Author(s)
  辺野喜智、吉成浩一、志津怜太、山添康
- Organizer
  日本癌学会第71回学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] Role of PXR in the xenobiotic induced hepatocyte proliferation2012
- Author(s)
  志津怜太、吉成浩一、辺野喜智、山添康
- Organizer
  日本癌学会第71回学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] ヒトCAR活性化物質検出のための新規レポーターアッセイ系の開発2012
- Author(s)
  吉成浩一、今井純、山添康
- Organizer
  第19回HAB研究機構学術年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] PXR依存的なCYP3A4遺伝子の転写活性化はLXRαにより抑制される2012
- Author(s)
  渡邊圭祐、吉成浩一、櫻井香織、山添康
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22659028
[Presentation] 核内受容体LXRαによるヒトCYP1A1およびCYP1A2 遺伝子の転写活性化2012
- Author(s)
  吉成浩一、荒木希久子、山添康
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] PXR活性化薬物の併用はCAR依存的なマウス肝細胞増殖を増強する2012
- Author(s)
  志津怜太、吉成浩一、辺野喜智、山添康
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] 核内受容体LXRαによるヒトCYP1A1およびCYP1A2遺伝子の転写活性化2012
- Author(s)
  吉成浩一、荒木希久子、山添康
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] The identification of cell cycle- associated genes regulated by CAR but not PXR2012
- Author(s)
  辺野喜智、吉成浩一、志津怜太、山添康
- Organizer
  日本癌学会第71回学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] 核内受容体CARはPPARα依存的にケトン体合成経路の律速酵素であるHMGCS2の転写を抑制する2012
- Author(s)
  大塚祐多、吉成浩一、山添康
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] 核内受容体CARはPPARα依存的にケトン体合成経路の律速酵素であるHMGCS2の転写を抑制する2012
- Author(s)
  大塚祐多、吉成浩一、山添康
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] ヒト活性化物質検出のための新規レポーターアッセイ系の開発2012
- Author(s)
  吉成浩一、今井純、山添康
- Organizer
  第19回HAB研究機構学術年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] 肝内胆汁酸レベルの抑制に関与するヒト回腸FGF19の転写調節機序2011
- Author(s)
  畑竜也、宮田昌明、吉成浩一、山添康
- Organizer
  第38回日本トキシコロジー学会
- Place of Presentation
  横浜
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] 新規胆汁酸-FXR応答配列を介したヒトFGF19遺伝子の転写活性化2011
- Author(s)
  畑竜也、宮田昌明、吉成浩一、山添康
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21390039
[Presentation] Dietary cholesterol-associated regulation of hepatic CYP3A gene expression2011
- Author(s)
  吉成浩一
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-22659028
[Presentation] ヒトマクロファージ様細胞における炎症関連遺伝子発現に対する核内受容体リガンドの影響2011
- Author(s)
  平田貴大、吉成浩一、山添康
- Organizer
  日本薬学会東北支部大会
- Place of Presentation
  仙台市
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-23659072
[Presentation] 毒性発現メカニズムの理解と有害性評価への応用を目指して2011
- Author(s)
  吉成浩一、化学物質の有害性を左右する核内受容体
- Organizer
  第10回日本化学工業協会LRI研究報告会(招待講演)
- Place of Presentation
  東京
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] EVALUATION OF CELL-BASED REPORTER ASSAY SYSTEMS FOR THE ASSESSMENT OF THE SPECIES-SELECTIVE LIGANDS OF CONSTITUTIVE ANDROSTANE RECEPTOR2011
- Author(s)
  今井純、吉成浩一、山添康
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島市
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] 化学物質の有害性を左右する核内受容体:毒性発現メカニズムの理解と有害性評価への応用を目指して2011
- Author(s)
  吉成浩一
- Organizer
  第10回日本化学工業協会LRI研究報告会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-23659072
[Presentation] 核内受容体を介した新規なCYP3A遺伝子発現調節機構2011
- Author(s)
  吉成浩一
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] Mechanisms for the xenobiotic-induced and physiological/nutritional condition-associated changes in the gene expression of drug-metabolizing enzymes2011
- Author(s)
  吉成浩一
- Organizer
  Asia-Pacific国際薬物動態学会(AP-ISSX)
- Place of Presentation
  台南(台湾)(招待講演)
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-22659028
[Presentation] ヒトマクロファージ様細胞における炎症関連遺伝子発現に対する核内受容体リガンドの影響2011
- Author(s)
  平田貴大、吉成浩一、山添康
- Organizer
  日本薬学会東北支部会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-23659072
[Presentation] 核内受容体を介した新規なCYP3A遺伝子発現調節機構2011
- Author(s)
  吉成浩一
- Organizer
  日本薬剤学会第26年会(招待講演)
- Place of Presentation
  東京
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] Mechanisms for the xenobiotic-induced and physiological/nutritional condition-associated changes in the gene expression of drug-metabolizing enzymes2011
- Author(s)
  Kouichi Yoshinari
- Organizer
  第4回Asia-Pacific国際薬物動態学会(AP-ISSX)
- Place of Presentation
  台南(台湾)
- Year and Date
  2011-04-23
- Data Source
  KAKENHI-PROJECT-22659028
[Presentation] Dietary Cholesterol-Associated Regulation of Hepatic CYP3A Gene Expression2011
- Author(s)
  吉成浩一
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島(招待講演)
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-22659028
[Presentation] Evaluation of cell-based reporter assay systems for the assessment of the species-selective ligands of constitutive androstane receptor2011
- Author(s)
  今井純、吉成浩一、山添康
- Organizer
  日本薬物動態学会第26年会
- Place of Presentation
  広島市
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] 化学物質の有害性を左右する核内受容体:毒性発現メカニズムの理解と有害性評価への応用を目指して2011
- Author(s)
  吉成浩一
- Organizer
  第10回日本化学工業協会LRI研究報告会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] Nuclear receptor CAR transactivates the expression of DHCR24 encoding a cholsterogenic enzyme, 24-dehydrocholesterol reductase, in human hepatocytes2010
- Author(s)
  吉成浩一
- Organizer
  第9回ISSX国際会議
- Place of Presentation
  イスタンブール(トルコ)
- Year and Date
  2010-09-05
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] Nuclear receptor CAR trans-activates the expression of DHCR24encoding a cholesterogenic enzyme,24-dehydrocholesterol reductase, inhuman hepatocytes2010
- Author(s)
  吉成浩一
- Organizer
  第9回ISSX国際会議
- Place of Presentation
  イスタンブール(トルコ)
- Year and Date
  2010-09-05
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] 工業化学物質のPXRおよびCAR活性化能の評価2010
- Author(s)
  今井純、吉成浩一、山添康
- Organizer
  第25回日本薬物動態学会学会
- Place of Presentation
  大宮市
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] ctivated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liver2010
- Author(s)
  Shin-ichi Inoue, Kouichi Yoshinari, Yasushi Yamazoe
- Organizer
  第9回国際薬物動態学会(ISSX)国際会議
- Place of Presentation
  イスタンブール(トルコ)
- Year and Date
  2010-09-05
- Data Source
  KAKENHI-PROJECT-22659028
[Presentation] in vitroレポーターアッセイを用いた工業化学物質のスクリーニング2010
- Author(s)
  吉成浩一、PXR活性化物質の種差プロファイリング
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  宜野湾市
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] PXR活性化物質の種差プロファイリング:in vitroレポーターアッセイを用いた工業化学物質のスクリーニング2010
- Author(s)
  吉成浩一
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄県宜野湾市
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-22390027
[Presentation] 薬物応答性核内受容体と医薬品副作用2009
- Author(s)
  吉成浩一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19790114
[Presentation] 食餌中の糖・脂質レベルが肝チトクロムP450発現レベルに及ぼす影響2008
- Author(s)
  菅原実香、吉成浩一、山添康
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19790114
[Presentation] CARによるヒトCYP1A1およびCYP1A2遺伝子の転写活性化2008
- Author(s)
  依田典朗、吉成浩一、山添康
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-19790114
[Presentation] リトコール酸によるCYP3A誘導におけるビタミンD受容体の役割2008
- Author(s)
  松原勤、吉成浩一、青山和誠、菅原実香、関谷裕次、永田清、山添康
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19790114
[Presentation] Role of vitamin D receptor in the lithocholic acid-mediated CYP3A induction2008
- Author(s)
  Tsutomu Matsubara, Kouichi Yoshinari, Kazunobu Aoyama, Mika Sugawara, Yuji Sekiya, Kiyoshi Nagata, Yasushi Yamazoe
- Organizer
  ISSX 15th North American Regional Meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-19790114
[Presentation] 外来異物によるCYP3A4遺伝子の転写活性化に必須な新規シスエレメント2008
- Author(s)
  鳥谷部貴祥、高田智成、荒津佑輔、松原勤、吉成浩一、永田清、山添康
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19790114
[Presentation] Involvements of N-hydroxylation of flutamde metabolite and hepatic GSH depletion in flutamide-induced hepatotoxicity2007
- Author(s)
  M. Ohbuchi, M. Miyata, D. Nagai, M. Shimada, K. Yoshinari and Y. Yamazoe
- Organizer
  8^<th> ISSX meeting
- Place of Presentation
  Sendai
- Year and Date
  2007-10-10
- Data Source
  KAKENHI-PROJECT-19390037

1. KAKIZAKI Satoru (80344935)

# of Collaborated Projects: 7 results

# of Collaborated Products: 3 results
2. MIYATA Masaaki (90239418)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
3. YAMAZOE Yasushi (00112699)

# of Collaborated Projects: 5 results

# of Collaborated Products: 37 results
4. 志津怜太 (50803912)

# of Collaborated Projects: 5 results

# of Collaborated Products: 59 results
5. Hosaka Takuomi (30611579)

# of Collaborated Projects: 4 results

# of Collaborated Products: 55 results
6. SUGATANI Junko (30098131)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
7. MIWA Masao (10046287)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
8. Yamazaki Yuichi (00582404)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. Sasaki Takamitsu (20382674)

# of Collaborated Projects: 3 results

# of Collaborated Products: 46 results
10. TOJIMA Hiroki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. TAHARA Hiroki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. OHMORI Shigeru (70169069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Abe Taiki (40810594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 児玉進 (20621460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山折大 (40360218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 堀口昇男 (10550022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 永田清 (80189133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 新堀哲也 (40436134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 青木洋子 (80332500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 井上裕介 (90304302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 柴田康博 (90344936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 松原勤 (20628698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 湯川博 (30634646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 中瀬生彦 (40432322)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TAKIZAWA Daichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KANNO Yuichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 松沢厚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshinari Kouichi 吉成 浩一

YOSHINARI Kouichi 吉成 浩一

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Investigation of the next-generation and late-onset effects of drugs focusing on liver maturation and liver function regulated by the nuclear receptors PXR and CARPrincipal Investigator

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Nuclear receptor PXR-mediated hepatocyte proliferation: understanding of its mechanism and human relevancePrincipal Investigator

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Understanding of molecular mechanism and development of prediction system of drug- induced hepatotoxicity, focusing on the inflammation-associated nuclear receptors and cell-cell interactions.Principal Investigator

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Understanding of the mechanism for the nuclear receptor-mediated hepatotoxicity and establishment of the prediction and evaluation system for the toxicity.Principal Investigator

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Yoshinari Kouichi 吉成浩一

YOSHINARI Kouichi 吉成浩一