SHIMOHATA Takayoshi 下畑享良

… Alternative Names

下畑享良シモハタタカヨシ

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Researcher Number	60361911
Other IDs	https://orcid.org/0000-0002-8788-9089
Affiliation (Current)	2024: 岐阜大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 岐阜大学, 大学院医学系研究科, 教授 2017: 岐阜大学, 医学部, 教授 2007 – 2016: Niigata University, 脳研究所, 准教授 2008: Niigata University, 研究所, 准教授 2004: 新潟大学, 脳研究所, 助手
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related / Neurochemistry/Neuropharmacology Except Principal Investigator Neurology / Basic Section 56010:Neurosurgery-related / Basic Section 52010:General internal medicine-related / Basic Section 47060:Clinical pharmacy-related / Basic Section 52020:Neurology-related / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology
Keywords	Principal Investigator VEGF / ラット / 脳虚血 / 血液脳関門 / 血栓溶解療法 / 血管内皮細胞増殖因子 / 大脳皮質基底核症候群 / 進行性核上性麻痺 / 神経変性疾患 / IgLON5 … More / 低酸素・低糖刺激 / 脳出血 / 末梢血単核球 / ミクログリア / 低酸素低糖刺激 / IL10 / 脳浮腫 / 脳梗塞 / TDP43 / 抗炎症 / 血管保護 / 神経細胞保護 / プログラニュリン / 小脳 / メチル水銀中毒 / 水俣病 / t-PA / 神経分子病態学 / 脳・神経 / 抗体療法 / 組織型プラスミノゲン・アクチベーター / 神経病態薬理学・脳虚血 … More Except Principal Investigator 脳梗塞 / 細胞療法 / 脳虚血 / 進行性核上性麻痺 / 末梢血単核球 / 血管新生 / ミクログリア / 神経変性疾患 / 多系統萎縮症 / miRNA / エクソソーム / 骨量 / 骨格筋量 / パーキンソン病 / 骨粗鬆症 / サルコペニア / パーキンソニズム / 診断 / 脳神経疾患 / 早期診断法 / タウタンパク質 / RT-Quic法 / 低酸素低糖刺激 / 保護療法 / 血管内皮増殖因子 / 極性化 / 脳血管障害 / 機能回復 / 神経軸索進展 / 極性変換 / 慢性期脳梗塞 / M2化 / M2 / 神経軸策伸展 / Presenilin / Neuronal cell death / Amyloid precursor protein / Transcription / Alzheimer disease / プレセニリン / 神経細胞死 / アミロイド前駆体タンパク / 転写障害 / アルツハイマー病 / 細胞移植療法 / 慢性期 / サイトカイン / VEGF / 血管リモデリング / 組織リモデリング / アンギオポエチン / 血管保護 / 脳塞栓モデル / アンギオポエチン1 / 病理学的解析 / 臨床研究 / 病理学的定量解析 / 臨床病理学的研究 / 神経病理学 / 認知機能障害 Less

4リピートタウオパチーの予防・診断を指向したRT-QUIC法の開発と創薬研究
- Principal Investigator
  
  位田雅俊
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Gifu Pharmaceutical University
Japanese prospective multicenter study on the prognostic influence of sarcopenia and osteoporosis in Parkinsonism
- Principal Investigator
  
  饗場郁子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Department of Clinical Research, National Hospital Organization Higashinagoya National Hospital
Anti-IgLON5 Antibody-Associated Disease: Development of Diagnostic Criteria and Identification of Predictors of Treatment ResponsePrincipal Investigator
- Principal Investigator
  
  下畑享良
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Gifu University
Development of brain regeneration therapy mediated by peripheral blood mononuclear cell-derived exosomes through cell polarization
- Principal Investigator
  
  金澤雅人
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Niigata University
Peripheral blood-derived mononuclear cells preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic stroke
- Principal Investigator
  
  Kanazawa Masato
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
Novel treatment using microglia preconditioned by oxygen glucose deprivation against cerebral hemorrhagePrincipal Investigator
- Principal Investigator
  
  SHIMOHATA TAKAYOSHI
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Gifu University
The establishment of therapeutic strategies of microglial transplantation against chronic ischemic stroke
- Principal Investigator
  
  Kanazawa Masato
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Analysis of progranulin as novel therapeutic target against ischemic strokePrincipal Investigator
- Principal Investigator
  
  SHIMOHATA Takayoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
Neuropathological analysis of multiple system atrophy with cognitive impairment
- Principal Investigator
  
  Tada Mari
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Niigata University
Vasoprotective protein Angiopoietin-1 is a novel therpeutic target molecule for cerebral ischemia
- Principal Investigator
  
  TAKAHASHI Tetsuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
Tissue remodeling by microglia for a novel therapeutic strategy in chronic cerebral ischemia
- Principal Investigator
  
  KANAZAWA Masato
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Analysis of vascular endothelial growth factor as novel therapeutic target for methylmercury poisoningPrincipal Investigator
- Principal Investigator
  
  SHIMOHATA Takayoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Establishment of selective VEGF inhibition treatment as a novel therapeutic strategy against ischemic strokePrincipal Investigator
- Principal Investigator
  
  SHIMOHATA Takayoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Analysis of the neurovascular protection by the novel therapeutic agent, BevacizumabPrincipal Investigator
- Principal Investigator
  
  SHIMOHATA Takayoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
A role of transcriptional impairment in pathogenesis for Alzheimer disease
- Principal Investigator
  
  IKEUCHI Takeshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University

[Book] 脳卒中エキスパート　神経保護・神経再生療法2021
- Author(s)
  下畑　享良
- Total Pages
  210
- Publisher
  中外医学社
- ISBN
  9784498328662
- Data Source
  KAKENHI-PROJECT-18K07496
[Book] Progranulin and Central Nervous System Disorders2021
- Author(s)
  Kanazawa M, Kawamura K, Takahashi T, Shimohata T
- Publisher
  Springer Singapore
- ISBN
  9789811361869
- Data Source
  KAKENHI-PROJECT-18K07493
[Journal Article] Cell Therapies under Clinical Trials and Polarized Cell Therapies in Pre-Clinical Studies to Treat Ischemic Stroke and Neurological Diseases: A Literature Review.2020
- Author(s)
  Hatakeyama M, Ninomiya I, Otsu Y, Omae K, Kimura Y, Onodera O, Fukushima M, Shimohata T, Kanazawa M.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 21 Issue: 17 Pages: 6194-6194
- DOI
  10.3390/ijms21176194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07496, KAKENHI-PROJECT-18K07493
[Journal Article] Strategies to prevent hemorrhagic transformation after reperfusion therapies for acute ischemic stroke: A literature review.2020
- Author(s)
  Otsu Y, Namekawa M, Toriyabe M, Ninomiya I, Hatakeyama M, Uemura M, Onodera O, Shimohata T, Kanazawa M.
- Journal Title
  
  J Neurol Sci.
  
  Volume: 419 Pages: 117217-117217
- DOI
  10.1016/j.jns.2020.117217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07496, KAKENHI-PROJECT-18K07493
[Journal Article] 総説脳梗塞に対する低酸素低糖刺激末梢血単核球療法2020
- Author(s)
  畠山公大，二宮至，小野寺理，下畑享良，金澤雅人
- Journal Title
  
  BRAIN and NERVE
  
  Volume: 72 Issue: 10 Pages: 1097-1103
- DOI
  10.11477/mf.1416201655
- ISSN
  1344-8129, 1881-6096
- Year and Date
  2020-10-01
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07496, KAKENHI-PROJECT-18K07493
[Journal Article] Angiogenesis in the ischemic core: A potential treatment target?2019
- Author(s)
  Kanazawa M, Takahashi T, Ishikawa M, Onodera O, Shimohata T, Del Zoppo GJ.
- Journal Title
  
  J Cereb Blood Flow Metab.
  
  Volume: Mar 6 Issue: 5 Pages: 753-769
- DOI
  10.1177/0271678x19834158
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07496, KAKENHI-PROJECT-18K07493
[Journal Article] A novel therapeutic approach using peripheral blood mononuclear cells preconditioned by oxygen-glucose deprivation.2019
- Author(s)
  Hatakeyama M, Kanazawa M, Ninomiya I, Omae K, Kimura Y, Takahashi T, Onodera O, Fukushima M, Shimohata T.
- Journal Title
  
  Sci Rep.
  
  Volume: ９ Issue: 1 Pages: 16819-16819
- DOI
  10.1038/s41598-019-53418-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07496, KAKENHI-PROJECT-18K07493
[Journal Article] VEGF—A therapeutic target against hemorrhagic transformation after t-PA treatment—2019
- Author(s)
  Kanazawa Masato、Takahashi Tetsuya、Kawamura Kunio、Shimohata Takayoshi
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 59 Issue: 11 Pages: 699-706
- DOI
  10.5692/clinicalneurol.cn-001346
- NAID
  130007742557
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07493
[Journal Article] Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke.2017
- Author(s)
  Kanazawa M, Ninomiya I, Hatakeyama M, Takahashi T, Shimohata T
- Journal Title
  
  Int J Mol Sci
  
  Volume: 18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19478
[Journal Article] Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats2017
- Author(s)
  Masato Kanazawa, Minami Miura, Masafumi Toriyabe, Misaki Koyama, Masahiro Hatakeyama, Masanori Ishikawa, Takashi Nakajima, Osamu Onodera, Tetsuya Takahashi, Masatoyo Nishizawa, Takayoshi Shimohata
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 42582-42582
- DOI
  10.1038/srep42582
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19478
[Journal Article] Therapeutic Strategies to Attenuate Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment for Acute Ischemic Stroke2017
- Author(s)
  Masato Kanazawa, Tetsuya Takahashi, Masatoyo Nishizawa, Takayoshi Shimohata
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 24 Issue: 3 Pages: 240-253
- DOI
  10.5551/jat.RV16006
- NAID
  130005397940
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19478
[Journal Article] プログラニュリン2016
- Author(s)
  金澤雅人, 川村　邦雄，高橋哲哉, 西澤正豊，下畑享良
- Journal Title
  
  日本臨床
  
  Volume: 74 Pages: 579-582
- Data Source
  KAKENHI-PROJECT-26430066
[Journal Article] 成長因子プログラニュリンによる脳保護療法2016
- Author(s)
  下畑享良，金澤雅人, 鳥谷部真史, 小山美咲, 高橋哲哉, 西澤正豊．
- Journal Title
  
  脳循環代謝
  
  Volume: 27 Pages: 265-269
- NAID
  130007040649
- Open Access
- Data Source
  KAKENHI-PROJECT-26430066
[Journal Article] 進歩する基礎研究－Progranulin－2016
- Author(s)
  金澤雅人，川村邦雄，高橋哲哉，西澤正豊，下畑　享良
- Journal Title
  
  日本臨床2016;74:579-582
  
  Volume: 74 Pages: 579-582
- Data Source
  KAKENHI-PROJECT-26430066
[Journal Article] Multiple therapeutic effects of progranulin on experimental acute ischemic stroke.2015
- Author(s)
  Kanazawa K, Kawamura K, Takahashi T, Miura M, Tanaka Y, Koyama M, Toriyabe M, Igarashi H, Nakada T, Nishihara M, Nishizawa M, Shimohata T
- Journal Title
  
  Brain
  
  Volume: 79 Issue: 7 Pages: 1-17
- DOI
  10.1093/brain/awv079
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-25860702, KAKENHI-PROJECT-26430066, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-25461310
[Journal Article] Effects of Alda-1, an aldehyde dehydrogenase-2 agonist, on hypoglycemic neuronal death2015
- Author(s)
  Ikeda T, Takahashi T, Tsujita M, Kanazawa M, Toriyabe M, Koyama M, Itoh K, Nakada T, Nishizawa M, Shimohata T
- Journal Title
  
  PLoS One
  
  Volume: 10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860702
[Journal Article] Effects of angiopoietin-1 on hemorrhagic transformation and cerebral edema after tissue plasminogen activator treatment for ischemic stroke in rats.2014
- Author(s)
  Kawamura K, Takahashi T, Kanazawa M, Igarashi H, Nakada T, Nishizawa M, Shimohata T.
- Journal Title
  
  PLoS One
  
  Volume: 9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860702
[Journal Article] Pathology and sensitivity of current clinical criteria in corticobasal syndrome.2014
- Author(s)
  Ouchi H, Toyoshima Y, Tada M, Oyake M, Aida I, Tomita I, Satoh A, Tsujihata M, Takahashi H, Nishizawa M, Shimohata T.
- Journal Title
  
  Mov Disord
  
  Volume: 29 Issue: 2 Pages: 238-44
- DOI
  10.1002/mds.25746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430048
[Journal Article] Effects of angiopoietin-1 on hemorrhagic transformation and cerebral edema after tissue plasminogen activator treatment for ischemic stroke in rats.2014
- Author(s)
  Kawamura K, Takahashi T, Kanazawa M, Igarashi H, Nakada T, Nishizawa M, Shimohata T
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 6 Pages: e98639-e98639
- DOI
  10.1371/journal.pone.0098639
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430063, KAKENHI-PROJECT-25461310
[Journal Article] Early clinical features of patients with progressive supranuclear palsy with predominant cerebellar ataxia.2013
- Author(s)
  Kanazawa M, Tada M, Onodera O, Takahashi H, Nishizawa M, Shimohata T.
- Journal Title
  
  Parkinsonism Relat Disord
  
  Volume: 19 Issue: 12 Pages: 1149-51
- DOI
  10.1016/j.parkreldis.2013.07.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430048
[Journal Article] Biochemical and histopathological alterations in TAR DNA-binding protein-43 after acute ischemic stroke in rats2011
- Author(s)
  Kanazawa M, Kakita A, Igarashi H, Takahashi T, Kawamura K, Takahashi H, Nakada T, Nishizawa M, Shimohata T
- Journal Title
  
  J Neurochem.
  
  Volume: Vol.116, No.6 Pages: 957-965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591073
[Journal Article] Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment2011
- Author(s)
  Kanazawa M, Igarashi H, Kawamura K, Takahashi T, Kakita A, Takahashi H, Nakada T, Nishizawa M, Shimohata T
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: Vol.31, No.6 Pages: 1461-1674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591073
[Journal Article] ポストt-PA時代の神経・血管保護療法2009
- Author(s)
  下畑享良, 金澤雅人, 高橋哲哉, 西澤正豊
- Journal Title
  
  新潟大学脳研究所神経内科県医師会報 706
  
  Pages: 2-6
- Data Source
  KAKENHI-PROJECT-19590982
[Journal Article] 綜説ポストtPA時代の神経・血管保護療法2009
- Author(s)
  下畑享良, 金澤雅人, 高橋哲哉, 西澤正豊
- Journal Title
  
  新潟県医師会報 706
  
  Pages: 1-5
- Data Source
  KAKENHI-PROJECT-19590982
[Journal Article] Epsilon PKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model.2007
- Author(s)
  Shimohata T Zhao H, Steinberg GK.
- Journal Title
  
  Stroke 38
  
  Pages: 375-380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590982
[Journal Article] Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hvpothermia.2007
- Author(s)
  Shimohata T, Zhao H, Sung JH, et. al.
- Journal Title
  
  J Cereb Blood Flow Metab. 27
  
  Pages: 1463-1475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590982
[Journal Article] Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusion.2007
- Author(s)
  Zhao H, Wang JQ, Shimohata T, et. al.
- Journal Title
  
  J Neurosurg. 107
  
  Pages: 636-641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590982
[Patent] Cell preparation and method for producing cell preparation2022
- Inventor(s)
  金澤雅人, 下畑享良
- Industrial Property Rights Holder
  Niigata University
- Industrial Property Rights Type
  特許
- Acquisition Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-18K07493
[Patent] 細胞製剤および細胞製剤の製造方法2022
- Inventor(s)
  金澤雅人, 下畑享良
- Industrial Property Rights Holder
  新潟大学
- Industrial Property Rights Type
  特許
- Acquisition Date
  2022
- Data Source
  KAKENHI-PROJECT-18K07493
[Patent] 94OGD（低酸素,低糖刺激）バッグに関する特許2022
- Inventor(s)
  金澤雅人、畠山公大、下畑享良、井川博史、尾前薫
- Industrial Property Rights Holder
  金澤雅人、畠山公大、下畑享良、井川博史、尾前薫
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-18K07493
[Patent] 細胞製剤の製造方法及びこれに用いる低酸素刺激用容器2021
- Inventor(s)
  金澤雅人、畠山公大、下畑享良、尾前薫、井川博史
- Industrial Property Rights Holder
  金澤雅人、畠山公大、下畑享良、尾前薫、井川博史
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18K07493
[Patent] 細胞製剤および細胞製剤の製造方法2018
- Inventor(s)
  金澤雅人，下畑享良
- Industrial Property Rights Holder
  金澤雅人，下畑享良
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18K07493
[Patent] 細胞製剤および細胞製剤の製造方法2017
- Inventor(s)
  金澤雅人，下畑享良
- Industrial Property Rights Holder
  金澤雅人，下畑享良
- Industrial Property Rights Type
  特許
- Filing Date
  2017-02-16
- Data Source
  KAKENHI-PROJECT-15K19478
[Patent] 細胞製剤および細胞製剤の製造方法2017
- Inventor(s)
  金澤雅人，下畑享良
- Industrial Property Rights Holder
  金澤雅人，下畑享良
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K19478
[Patent] 細胞製剤および細胞製剤の製造方法2016
- Inventor(s)
  下畑　享良
- Industrial Property Rights Holder
  新潟大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-168543
- Filing Date
  2016-08-30
- Overseas
- Data Source
  KAKENHI-PROJECT-26430066
[Patent] 虚血後の再灌流に起因する出血を予防するための薬剤2014
- Inventor(s)
  下畑　享良
- Industrial Property Rights Holder
  新潟大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-09-30
- Overseas
- Data Source
  KAKENHI-PROJECT-26430066
[Patent] 虚血性イベントの治療用医薬品組成物2010
- Inventor(s)
  下畑享良
- Industrial Property Rights Holder
  新潟大学
- Filing Date
  2010-07-27
- Overseas
- Data Source
  KAKENHI-PROJECT-21591073
[Patent] 免疫製剤を含む脳梗塞治療用医薬品組成物2009
- Inventor(s)
  下畑享良
- Industrial Property Rights Holder
  新潟大学
- Industrial Property Number
  2009-174098
- Filing Date
  2009-08-11
- Data Source
  KAKENHI-PROJECT-21591073
[Patent] 受容体シグナル伝達阻害剤を含む脳梗塞治療用医薬品組成物2009
- Inventor(s)
  下畑享良
- Industrial Property Rights Holder
  新潟大学
- Industrial Property Number
  2009-174099
- Filing Date
  2009-08-11
- Data Source
  KAKENHI-PROJECT-21591073
[Presentation] A therapeutic approach using peripheral blood mononuclear cells preconditioned by oxygen-glucose deprivation in ischemic rats2021
- Author(s)
  Kanazawa M, Hatakeyama M, Ninomiya I, Omae K, Kimura Y, Takahashi T, Onodera O, Fukushima M, Shimohata T
- Organizer
  The Annual Meeting of American Academy of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07493
[Presentation] A therapeutic approach using peripheral blood mononuclear cells preconditioned by oxygen-glucose deprivation in ischemic rats2021
- Author(s)
  78Hatakeyama M, Kanazawa M, Ninomiya I, Omae K, Kimura Y, Takahashi T, Onodera O, Fukushima M, Shimohata T
- Organizer
  The International Stroke Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07493
[Presentation] A therapeutic approach using peripheral blood mononuclear cells preconditioned by oxygen-glucose deprivation in ischemic rats2020
- Author(s)
  Hatakeyama Masahiro、Kanazawa Masato、Ninomiya Itaru、Omae Kaoru、Kimura Yasuko、Takahashi Tetsuya、Onodera Osamu、Fukushima Masanori、Shimohata Takayoshi
- Organizer
  神経学会学術大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07493
[Presentation] A therapy using peripheral blood cells preconditioned by oxygen-glucose deprivation against ischemia2020
- Author(s)
  Hatakeyama Masahiro、Kanazawa Masato、Ninomiya Itaru、Omae Kaoru、Kimura Yasuko、Takahashi Tetsuya、Onodera Osamu、Fukushima Masanori、Shimohata Takayoshi
- Organizer
  日本神経学会学術大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07493
[Presentation] A therapeutic approach using peripheral blood mononuclear cells preconditioned by oxygen-glucose deprivation in ischemic rats2020
- Author(s)
  Hatakeyama Masahiro、Kanazawa Masato、Ninomiya Itaru、Omae Kaoru、Kimura Yasuko、Takahashi Tetsuya、Onodera Osamu、Fukushima Masanori、Shimohata Takayoshi
- Organizer
  International Stroke Conference 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07493
[Presentation] ラクナ梗塞とBranch atheromatous diseaseの鑑別における、入院時血清PTX3値の有用性の検討2020
- Author(s)
  二宮格、金澤雅人、上村昌寛、下畑享良、小野寺理
- Organizer
  日本脳卒中学会
- Data Source
  KAKENHI-PROJECT-18K07493
[Presentation] 脳梗塞に対する低酸素低糖刺激末梢血単核球を用いた細胞療法2020
- Author(s)
  畠山公大，金澤雅人，二宮格，尾前薫，木村泰子，高橋哲哉，小野寺理，福島雅典，下畑享良
- Organizer
  第63回日本脳循環代謝学会
- Data Source
  KAKENHI-PROJECT-18K07496
[Presentation] Branch Atheromatous Diseaseにおける急性期の血清Lox-1値の検討2019
- Author(s)
  二宮格、金澤雅人、赤岩靖久、下畑享良、小野寺理
- Organizer
  日本神経学会学術大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07493
[Presentation] トランスレーショナルリサーチの実践2019
- Author(s)
  下畑　享良
- Organizer
  第44回日本脳卒中学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07496
[Presentation] VEGF ~A therapeutic target against hemorrhagic transformation after t-PA treatment~2018
- Author(s)
  Masato Kanazawa, Tetsuya Takahashi, Takayoshi Shimohata
- Organizer
  日本神経学会学術大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07493
[Presentation] Preconditioned protective microglia by oxygen-glucose deprivation promote functional recovery in ischemic rats2017
- Author(s)
  Kanazawa M, Miura M, Toriyabe M, Koyama M, Hatakeyama M, Ishikawa M, Nakajima T, Onodera O, Takahashi T, Nishizawa M, Shimohata T
- Organizer
  World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19478
[Presentation] 脳梗塞後遺症の機能回復を目指した低酸素低糖刺激M2化ミクログリア移植療法2017
- Author(s)
  金澤雅人，三浦南，鳥谷部真史，小山美咲，畠山公大，中島孝，小野寺理，高橋哲哉，西澤正豊，下畑享良
- Organizer
  STROKE2017 第42回日本脳卒中学会学術集会
- Place of Presentation
  大阪国際会議場，大阪市
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-15K19478
[Presentation] Preconditioned microglia by oxygen-glucose deprivation promote functional recovery in ischemic rats2017
- Author(s)
  Kanazawa M, Miura M, Toriyabe M, Koyama M, Hatakeyama M, Ishikawa M, Nakajima T, Onodera O, Takahashi T, Nishizawa M, Shimohata T
- Organizer
  8th Korea/Japan Stroke Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19478
[Presentation] Preconditioned M2 microglia by oxygen-glucose deprivation promote functional recovery in ischemic rats2017
- Author(s)
  Kanazawa M, Miura M, Toriyabe M, Koyama M, Hatakeyama M, Ishikawa M, Nakajima T, Onodera O, Takahashi T, Nishizawa M, Shimohata T
- Organizer
  Annual meeting of American Academy of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19478
[Presentation] 脳梗塞後遺症の機能回復を目指した低酸素低糖刺激保護的ミクログリア細胞療法2017
- Author(s)
  金澤雅人，三浦南，鳥谷部真史，小山美咲，畠山公大，石川正典，中島孝，小野寺理，高橋哲哉，西澤正豊，下畑享良
- Organizer
  日本脳循環代謝学会総会
- Data Source
  KAKENHI-PROJECT-15K19478
[Presentation] M2 microglia preconditioned by oxygen-glucose deprivation promotes functional recovery in ischemic rats2017
- Author(s)
  Masato Kanazawa, Minami Miura, Masafumi Toriyabe, Misaki Koyama, Masahiro Hatakeyama, Masanori Ishikawa, Takashi Nakajima, Osamu Onodera, Tetsuya Takahashi, Masatoyo Nishizawa, Takayoshi Shimohata
- Organizer
  International Stroke Conference 2017
- Place of Presentation
  Houston, TX, USA
- Year and Date
  2017-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19478
[Presentation] Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats2017
- Author(s)
  Kanazawa M, Miura M, Toriyabe M, Koyama M, Hatakeyama M, Ishikawa M, Nakajima T, Onodera O, Takahashi T, Nishizawa M, Shimohata T
- Organizer
  XXVIIIth International Symposium on Cerebral Blood Flow, Metabolism
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19478
[Presentation] 脳虚血に対する新規脳保護薬としてのプログラニュリン．2016
- Author(s)
  下畑享良，金澤雅人，鳥谷部真史，高橋哲哉．
- Organizer
  第1回プログラニュリン研究会
- Place of Presentation
  岐阜大学サテライトキャンパス岐阜スカイウイング37（岐阜県岐阜市）
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-26430066
[Presentation] Neuroprotective effect of progranulin against focal cerebral ischemia via inhibition of proteolysis of TDP-43 by caspase-32016
- Author(s)
  Masato Kanazawa, Masafumi Toriyabe, Misaki Koyama, Minami Miura, Tetsuya Takahashi, Masatoyo Nishizawa, Takayoshi Shimohata
- Organizer
  Annual Meeting of American Academy of Neurology 2016
- Place of Presentation
  Vancouver, BC, Canada
- Year and Date
  2016-04-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19478
[Presentation] Therapeutic strategies against hemorrhagic transformation after t-PA treatment2015
- Author(s)
  Masato Kanazawa, Tetsuya Takahashi, Kunio Kawamura, Masatoyo Nishizawa, Takayoshi Shimohata
- Organizer
  日本神経学会
- Place of Presentation
  ときメッセ（新潟県・新潟市）
- Year and Date
  2015-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-15K19478
[Presentation] 成長因子プログラニュリンによる脳保護療法2015
- Author(s)
  下畑　享良
- Organizer
  第27回日本脳循環代謝学会総会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Year and Date
  2015-10-30
- Invited
- Data Source
  KAKENHI-PROJECT-26430066
[Presentation] Effects of angiopoietin-1 on hemorrhagic transformation and cerebral edema after tissue plasminogen activator treatment for ischemic stroke2014
- Author(s)
  Takayoshi Shimohata
- Organizer
  International Stroke Conference 2014
- Place of Presentation
  サンジエゴ（米国）
- Data Source
  KAKENHI-PROJECT-25430063
[Presentation] ラットメチル水銀亜急性中毒モデルにおける血管内皮細胞成長因子(VEGF) 抑制療法の検討2013
- Author(s)
  高橋哲哉, 藤村成剛, 臼杵扶佐子, 西澤正豊, 下畑享良
- Organizer
  第25回日本脳循環代謝学会総会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-24659426
[Presentation] ラットメチル水銀亜急性中毒モデルにおける血管内皮細胞成長因子(VEGF) 抑制療法の検討2013
- Author(s)
  高橋哲哉, 藤村成剛, 臼杵扶佐子, 西澤正豊, 下畑享良
- Organizer
  第54 回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659426
[Presentation] VEGFシグナル阻害はtPAによる血栓溶解療法後の脳出血を抑制する2011
- Author(s)
  下畑享良,金澤雅人,五十嵐博中,高橋哲哉,川村邦雄,柿田明美,高橋均,中田力,西澤正豊
- Organizer
  日本神経学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21591073
[Presentation] 急性脳虚血によるIII)P-43の生化学的・組織学的変化の検討2010
- Author(s)
  下畑享良
- Organizer
  第22回日本脳循環代謝学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-21591073
[Presentation] TDP43 may contribute to the protective effects of hypothermia against rat focal cerebral ischemia2009
- Author(s)
  Kanazawa M, Kakita A, Igarashi H, Takahashi T, Takahashi H, Nishizawa M, Nakada T, Shimohata T
- Organizer
  International stroke conference 2009
- Place of Presentation
  サン・ディエゴ
- Year and Date
  2009-02-19
- Data Source
  KAKENHI-PROJECT-19590982
[Presentation] ラット中大脳動脈塞栓モデルにおける血管内皮細胞のVEGF発現2008
- Author(s)
  金澤雅人, 五十嵐博中, 柿田明美, 高橋均, 西澤正豊, 下畑享良
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19590982
[Presentation] ラット中大脳動脈塞栓モデルにおける血管内皮細胞のVEGF発現2008
- Author(s)
  金澤雅人, 五十嵐博中, 柿田明美, 高橋均, 西澤正豊, 下畑享良
- Organizer
  日本神経学会総会
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19590982
[Presentation] TDP43 may contribute to the protective effects of hypothermia against rat focal cerebral ischemia2008
- Author(s)
  Kanazawa M, Kakita A, Igarashi H, Takahashi T, Nishizawa M, Nakada T, and Shimohata T
- Organizer
  International Stroke conference 2008
- Place of Presentation
  SanDiego
- Year and Date
  2008-02-19
- Data Source
  KAKENHI-PROJECT-19590982
[Presentation] 低体温療法は〓PKC活性化の抑制を介しての神経保護作用を発揮する2007
- Author(s)
  下畑享良, 西澤正豊, Steinberg G
- Organizer
  日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-17
- Data Source
  KAKENHI-PROJECT-19590982
[Presentation] Vascular endothelial growth factor upregulation in blood brain barrier in rat models of subacute methylmercury intoxication
- Author(s)
  Tetsuya Takahashi, Masatake Fujimura, Fusako Usuki, Masatoyo Nishizawa, Takayoshi Shimohata
- Organizer
  65th American Academy of Neurology Annual Meeting
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-24659426
[Presentation] プログラニュリンは実験虚血モデルにおいて，多面的治療効果をもつ
- Author(s)
  金澤　雅人,　川村　邦雄,　高橋　哲哉,　三浦　南,　田中　良法,　小山　美咲, 鳥谷部　真史,　五十嵐　博中,　中田　力,　西原　眞杉,　西澤　正豊,　下畑　享良
- Organizer
  日本脳卒中学会総会
- Place of Presentation
  広島, リーガロイヤルホテル広島
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25860702
[Presentation] プログラニュリンは神経細胞保護効果・抗炎症作用をもつ
- Author(s)
  三浦　南,　金澤　雅人,　川村　邦雄,　高橋　哲哉,　田中　良法,　小山　美咲, 鳥谷部　真史,　五十嵐　博中,　中田　力,　西原　眞杉,　西澤　正豊,　下畑　享良
- Organizer
  日本脳循環代謝学会総会
- Place of Presentation
  岡山, 岡山コンベンションセンター
- Year and Date
  2014-11-20 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-25860702
[Presentation] 脳虚血におけるヘパラナーゼによるヘパラン硫酸プロテオグリカンの修飾
- Author(s)
  金澤　雅人, Yu-Huan Gu, 長田　高志,　Brian T. Hawkins,　福田　俊一,　中島　元夫,　下畑　享良,　西澤　正豊,　Gregory J. del Zoppo
- Organizer
  日本病態プロテアーゼ学会学術集会
- Place of Presentation
  大阪, 千里ライフサイエンスセンター
- Year and Date
  2014-08-08 – 2014-08-09
- Data Source
  KAKENHI-PROJECT-25860702
[Presentation] Effects of angiopoietin-1 on hemorrhagic transformation and cerebral edema after tissue plasminogen activator treatment for ischemic stroke
- Author(s)
  Masato Kanazawa, Kunio Kawamura, Tetsuya Takahashi, Hironaka Igarashi, Tsutomu Nakada, Masatoyo Nishizawa, Takayoshi Shimohata
- Organizer
  Annual Meeting of American Academy of Neurology
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2014-04-28 – 2014-05-03
- Data Source
  KAKENHI-PROJECT-25860702
[Presentation] Multiple therapeutic effects of progranulin on experimental acute ischemic stroke
- Author(s)
  Masato Kanazawa, Kunio Kawamura, Tetsuya Takahashi, Minami Miura, Yoshinori Tanaka, Misaki Koyama, Masafumi Toriyabe, Hironaka Igarashi, Tsutomu Nakada, Masugi Nishihara, Masatoyo Nishizawa, Takayoshi Shimohata
- Organizer
  International Stroke Conference of American Stroke Association
- Place of Presentation
  Nashville, USA
- Year and Date
  2015-02-12 – 2015-02-14
- Data Source
  KAKENHI-PROJECT-25860702
[Presentation] アンギオポエチン１による血栓溶解療法に伴う脳出血合併症の予防効果
- Author(s)
  金澤　雅人,　川村　邦雄,　高橋　哲哉,　五十嵐　博中,　中田　力,　西澤　正豊,　下畑　享良
- Organizer
  日本神経学会学術大会
- Place of Presentation
  福岡, 福岡国際会議場
- Year and Date
  2014-05-21 – 2014-05-23
- Data Source
  KAKENHI-PROJECT-25860702
[Presentation] プログラニュリンは実験虚血モデルにおいて，多面的治療効果をもつ
- Author(s)
  金澤雅人、川村邦雄、高橋哲哉、田中良法、三浦南、小山美咲、鳥谷部真史、五十嵐博中、中田力、西原眞杉、西澤正豊、下畑享良
- Organizer
  第40回日本脳卒中学会
- Place of Presentation
  リーガロイヤルホテル広島
- Year and Date
  2015-03-26 – 2015-03-29
- Invited
- Data Source
  KAKENHI-PROJECT-26430066
[Presentation] ラットメチル水銀亜急性中毒モデルにおける血管内皮細胞成長因子（VEGF）発現の検討
- Author(s)
  高橋　哲哉、藤村成剛、臼杵扶佐子、西澤正豊、下畑享良
- Organizer
  第53回神経学会学術集会
- Place of Presentation
  東京・国際フォーラム
- Data Source
  KAKENHI-PROJECT-24659426

1. KANAZAWA Masato (80645101)

# of Collaborated Projects: 7 results

# of Collaborated Products: 39 results
2. TAKAHASHI Tetsuya (20515663)

# of Collaborated Projects: 6 results

# of Collaborated Products: 31 results
3. IGARASHI Hironaka (20231128)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. USUKI Fusako (50185013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. FUJIMURA Masatake (20416564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. Tada Mari (30646394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. NISHIZAWA Masatoyo (80198457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. TAKAHASHI Hitoshi (90206839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. IKEUCHI Takeshi (20372469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 成瀬聡 (70313541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 位田雅俊 (70512424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 本田諒 (00820143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 饗場郁子 (70501005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 玉腰暁子 (90236737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 矢部一郎 (60372273)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 波田野琢 (60338390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山田実 (30525572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 高松泰行 (40802096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 澤田誠 (40564894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 金子真理子 (40939782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 橋本里奈 (10915193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 安井敬三 (70776583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 會田隆志 (10943087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 畠山公大 (20843618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 田井中一貴 (80506113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIMOHATA Takayoshi 下畑 享良

下畑 享良 シモハタ タカヨシ

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Anti-IgLON5 Antibody-Associated Disease: Development of Diagnostic Criteria and Identification of Predictors of Treatment ResponsePrincipal Investigator

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Novel treatment using microglia preconditioned by oxygen glucose deprivation against cerebral hemorrhagePrincipal Investigator

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Analysis of progranulin as novel therapeutic target against ischemic strokePrincipal Investigator

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Analysis of vascular endothelial growth factor as novel therapeutic target for methylmercury poisoningPrincipal Investigator

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Establishment of selective VEGF inhibition treatment as a novel therapeutic strategy against ischemic strokePrincipal Investigator

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Analysis of the neurovascular protection by the novel therapeutic agent, BevacizumabPrincipal Investigator

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SHIMOHATA Takayoshi 下畑享良

下畑享良シモハタタカヨシ

[Book] 脳卒中エキスパート　神経保護・神経再生療法2021

[Journal Article] 総説脳梗塞に対する低酸素低糖刺激末梢血単核球療法2020