Nishijima Hitoshi 西嶋仁

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NISHIJIMA Hitoshi 西嶋仁

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Researcher Number	60425410
Affiliation (Current)	2025: 東京医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 東京医科大学, 医学部, 講師 2022: 徳島大学, 先端酵素学研究所(次世代), 助教 2016 – 2019: 徳島大学, 先端酵素学研究所(次世代), 助教 2011 – 2015: 徳島大学, 疾患酵素学研究センター, 助教 2006: National Institute of Genetics, Assistant Prof., 助手 2006: 国立遺伝学研究所, 総合遺伝研究系, 助手
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Immunology / Collagenous pathology/Allergology / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Collagenous pathology/Allergology / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 54020:Connective tissue disease and allergy-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / General medical chemistry / Biological Sciences
Keywords	Principal Investigator AIRE / 負の選択 / mTEC / 自己免疫疾患 / Aire / 免疫学 / 遺伝子改変マウス / 分子イメージング / BiTE抗体療法 / hCD3 … More / hCD19 / サイトカイン産生 / 腫瘍殺傷能力 / effector T細胞 / TCRマイクロクラスター / BiTE / 胸腺髄質上皮細胞 / Xcr1陽性樹状細胞 / 1型糖尿病 / RNA-seq / 遺伝子発現 / 胸腺上皮細胞 / AIRE遺伝子 / NOD / 自己免疫 / 糖尿病 … More Except Principal Investigator 自己免疫疾患 / I型糖尿病 / 胸腺 / Aire / AIRE / 樹状細胞 / 遺伝子改変マウス / CAF-1 / DDM1 / ヌクレオソーム / イメージング / ICOS / 2B4 / 免疫チェックポイント / 免疫シナプス / マイクロクラスター / シグナル伝達分子 / CAR-T細胞 / シグナル伝達 / 分子イメージング / キメラ抗原受容体 / T細胞補助刺激受容体 / 細胞療法 / 骨髄移植 / 抗原提示細胞 / 多発性筋炎 / 自己免疫 / epigenetics / chromatin replication / DNA replication / nucleosome / chromatin / モノユビキチン化 / 細胞記憶 / ジーンターゲティング / ヒストン / ヌクレオソームアセンブリー / クロマチン複製 / DNA複製 / ジーンサイレンシング / モノユビキチン / fas / macroH2A / クロマチン / ノックインマウス / 胸腺髄質上皮細胞 / autoimmunity / thymus / ヘテロクロマチン / ヒストン修飾 / リモデリング因子 / DNAメチル化 / ヘテロマクチン / non-coding RNA Less

新規ヒトCD３ε発現マウスモデルを用いた二重特異性抗体の時空間的機能解析Principal Investigator
- Principal Investigator
  
  西嶋仁
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Medical University
Development of the basis of the crosstalk between T cell costimulatory receptors and chimeric antigen receptors
- Principal Investigator
  
  横須賀忠
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
先端的分子イメージング法を基盤としたBiTE抗体療法の解析Principal Investigator
- Principal Investigator
  
  西嶋仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Medical University
Elucidation of the pathogenesis of autoimmune diseases based on AIRE and development of novel therapies for the autoimmune diseases
- Principal Investigator
  
  MATSUMOTO Mitsuru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  The University of Tokushima
Studies on the mechanisms underlying autoimmune ambivalence
- Principal Investigator
  
  MATSUMOTO Mitsuru
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  The University of Tokushima
Analysis of AIRE-dependent gene-expression network which controls the differentiation of mTECsPrincipal Investigator
- Principal Investigator
  
  NISHIJIMA Hitoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokushima
Elucidation of the pathogenesis of autoimmune disease through the functional study of AIRE
- Principal Investigator
  
  MATSUMOTO Mitsuru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokushima
Studies on the mechanisms for autoimmune phenotype in disease model mousePrincipal Investigator
- Principal Investigator
  
  NISHIJIMA Hitoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokushima
Studies aiming the establishing self-tolerance for the cure of autoimmune disease
- Principal Investigator
  
  MATSUMOTO Mitsuru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  The University of Tokushima
Studies on the mechanisms for the prevention of diabetes in NOD mice by AIRE expressionPrincipal Investigator
- Principal Investigator
  
  NISHIJIMA Hitoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokushima
DDM1によるヘテロクロマチン形成にRNA分子が関与する可能性
- Principal Investigator
  
  SHIBAHARA Kei-ichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Genetics
Chromatin replication through cellular proliferation in eukaryotic cells
- Principal Investigator
  
  SHIBAHARA Kei-ichi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  National Institute of Genetics

[Book] Basic Immunology and Its Clinical Application2024
- Author(s)
  Nishi Wataru, Ei Wakamatsu, Hiroaki Machiyama, Ryohei Matsushima, Yosuke Yoshida, Tetsushi Nishikawa, Hiroko Toyota, Masae Furuhata, Hitoshi Nishijima, Arata Takeuchi, Makoto Suzuki, Tadashi Yokosuka
- Total Pages
  258
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23K27466
[Journal Article] Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters2023
- Author(s)
  Nishi Wataru、Wakamatsu Ei、Machiyama Hiroaki、Matsushima Ryohei、Saito Kensho、Yoshida Yosuke、Nishikawa Tetsushi、Takehara Tomohiro、Toyota Hiroko、Furuhata Masae、Nishijima Hitoshi、Takeuchi Arata、Azuma Miyuki、Suzuki Makoto、Yokosuka Tadashi
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1-16
- DOI
  10.1038/s41467-023-38512-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07124, KAKENHI-PROJECT-22K07261, KAKENHI-PROJECT-22K08487, KAKENHI-PUBLICLY-23H04790, KAKENHI-PROJECT-23K27466
[Journal Article] AIRE - The Autoimmune Regulator2019
- Author(s)
  Matsumoto Minoru、Nishijima Hitoshi、Morimoto Junko、Tsuneyama Koichi、Matsumoto Mitsuru
- Journal Title
  
  eLS
  
  Volume: 1 Pages: 1-8
- DOI
  10.1002/9780470015902.a0027281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08885, KAKENHI-PROJECT-18K19564, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06496, KAKENHI-PROJECT-16H05342, KAKENHI-PROJECT-19K16613
[Journal Article] ヒトAIREを発現させたNODマウスに認められる自己免疫応答2019
- Author(s)
  西嶋仁、松本満
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71 Pages: 490-496
- Data Source
  KAKENHI-PROJECT-18K19564
[Journal Article] Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms2019
- Author(s)
  Matsumoto Minoru、Tsuneyama Koichi、Morimoto Junko、Hosomichi Kazuyoshi、Matsumoto Mitsuru、Nishijima Hitoshi
- Journal Title
  
  International Immunology
  
  Volume: 32 Issue: 2 Pages: 117-131
- DOI
  10.1093/intimm/dxz066
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07069, KAKENHI-PROJECT-19K07626, KAKENHI-PROJECT-19K16613, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06502, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-19H03699, KAKENHI-PROJECT-17K08885, KAKENHI-PROJECT-18K19564, KAKENHI-PLANNED-16H06496
[Journal Article] ヒトAIREを発現させたNODマウスに認められる自己免疫応答2019
- Author(s)
  西嶋　仁、松本　満
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71 Pages: 490-496
- Data Source
  KAKENHI-PROJECT-19H03699
[Journal Article] Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE)2018
- Author(s)
  Nishijima Hitoshi、Kajimoto Tatsuya、Matsuoka Yoshiki、Mouri Yasuhiro、Morimoto Junko、Matsumoto Minoru、Kawano Hiroshi、Nishioka Yasuhiko、Uehara Hisanori、Izumi Keisuke、Tsuneyama Koichi、Okazaki Il-mi、Okazaki Taku、Hosomichi Kazuyoshi、Shiraki Ayako、Shibutani Makoto、Mitsumori Kunitoshi、Matsumoto Mitsuru
- Journal Title
  
  Journal of Autoimmunity
  
  Volume: 86 Pages: 75-92
- DOI
  10.1016/j.jaut.2017.09.006
- NAID
  120006532435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08885, KAKENHI-PROJECT-17K19804, KAKENHI-PLANNED-16H06502, KAKENHI-PROJECT-18K19564, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06496, KAKENHI-PROJECT-16H05342, KAKENHI-PROJECT-16K08840
[Journal Article] Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G2018
- Author(s)
  Morimoto Junko、Nishikawa Yumiko、Kakimoto Takumi、Furutani Kohei、Kihara Naoki、Matsumoto Minoru、Tsuneyama Koichi、Kozono Yuko、Kozono Haruo、Hozumi Katsuto、Hosomichi Kazuyoshi、Nishijima Hitoshi、Matsumoto Mitsuru
- Journal Title
  
  The Journal of Immunology
  
  Volume: 201 Issue: 11 Pages: 3244-3257
- DOI
  10.4049/jimmunol.1800950
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08885, KAKENHI-PROJECT-18K07069, KAKENHI-PROJECT-18K19564, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06496, KAKENHI-PLANNED-16H06502, KAKENHI-PROJECT-16H05342, KAKENHI-PROJECT-17K19804
[Journal Article] Aire Expression Is Inherent to Most Medullary Thymic Epithelial Cells during Their Differentiation Program.2015
- Author(s)
  Kawano H, Nishijima H, Morimoto J, Hirota F, Morita R, Mouri Y, Nishioka Y, Matsumoto M.
- Journal Title
  
  Journal of Immunology
  
  Volume: 195 Issue: 11 Pages: 5149-5158
- DOI
  10.4049/jimmunol.1501000
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460577, KAKENHI-PROJECT-26461464, KAKENHI-PROJECT-25860363, KAKENHI-PROJECT-25293223
[Journal Article] Ectopic Aire expression in 1 the thymic cortex reveals inherent properties of Aire as a tolerogenic factor within the medulla2015
- Author(s)
  Nishijima H, Kitano S, Miyachi H, Morimoto J, Kawano H, Hirota F, Morita R, Mouri Y, Masuda K, Imoto I, Ikuta K, Matsumoto M.
- Journal Title
  
  J Immunol
  
  Volume: 195 Issue: 10 Pages: 4641-4649
- DOI
  10.4049/jimmunol.1501026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08949, KAKENHI-PROJECT-26460577, KAKENHI-PROJECT-26461464, KAKENHI-PUBLICLY-15H01153, KAKENHI-PROJECT-25460589, KAKENHI-PROJECT-25860363, KAKENHI-PROJECT-25293223
[Journal Article] Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program2014
- Author(s)
  Nishikawa, Y., Nishijima, H., Matsumoto, M., Morimoto, J., Hirota, F., Takahashi, S., Luche, H., Fehling, H.J., Mouri, Y., Matsumoto, M.
- Journal Title
  
  J. Immunol
  
  Volume: 192 Issue: 6 Pages: 2585-2592
- DOI
  10.4049/jimmunol.1302786
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591437, KAKENHI-PROJECT-25293223, KAKENHI-PROJECT-25293232, KAKENHI-PROJECT-25860363, KAKENHI-PROJECT-26460577, KAKENHI-PROJECT-26670502
[Journal Article] NIK in thymic stroma establishes central tolerance by orchestrating cross-talk with not only thymocytes but also dendritic cells2014
- Author(s)
  Mouri, Y., Nishijima, H., Kawano, H., Hirota, F., Sakaguchi, N., Morimoto, J., Matsumoto, M.
- Journal Title
  
  J. Immunol.
  
  Volume: 193 Issue: 9 Pages: 4356-4367
- DOI
  10.4049/jimmunol.1400389
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293223, KAKENHI-PROJECT-25860363, KAKENHI-PROJECT-26460577, KAKENHI-PROJECT-26461464
[Journal Article] Which model better fits the role of Aire in the establishment of self-tolerance: the transcription model or the maturation model?2013
- Author(s)
  Matsumoto, M., Nishikawa, Y., Nishijima, H., Morimoto, J., Matsumoto, M., Mouri, Y.
- Journal Title
  
  Front. Immunol.
  
  Volume: 4 Pages: 1-4
- DOI
  10.3389/fimmu.2013.00210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591437, KAKENHI-PROJECT-25293223, KAKENHI-PROJECT-25860363
[Journal Article] Histone acetyltransferase I is dispensable for replication-coupled chromatin assembly but contributes to recover DNA damages created following replication blockage in vertebrate cells.2006
- Author(s)
  Barman, HK., Takami, Y., Ono T., Nishijima, H., Sanematsu, F., Shibahara, K-i., Nakayama, T.
- Journal Title
  
  Biochem Biophys Res Commun 345
  
  Pages: 1547-1557
- Data Source
  KAKENHI-PROJECT-17026036
[Journal Article] Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.2006
- Author(s)
  Nishijima, H.
- Journal Title
  
  Mol. Biol. Cell 17
  
  Pages: 2524-2536
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390085
[Journal Article] Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.2006
- Author(s)
  Nishijima, H.
- Journal Title
  
  Mol.Biol.Cell. (in press)
- Data Source
  KAKENHI-PROJECT-16390085
[Journal Article] Histone acetyltransfcrase 1 is dispensable for replication-coupled chromatin assembly but contributes to recover DNA damages created following replication blockage in vertebrate cells.2006
- Author(s)
  Barman, HK., Takami Y., Ono T., Nishijima, H., Sanematsu, F., Shibahara, K-i., Nakayama, T.
- Journal Title
  
  Biochem Biophys Res Commun 345
  
  Pages: 1547-1557
- Data Source
  KAKENHI-PROJECT-16390085
[Journal Article] Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.2006
- Author(s)
  Nishijima, H.
- Journal Title
  
  Mol.Biol.Cell 17
  
  Pages: 2524-2536
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390085
[Journal Article] Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.2006
- Author(s)
  Nishijima, H., Nakayama, JI., Yoshioka, T., Kusano, A., Nishitani, H., Shibahara, K-i., Nishimoto, T.
- Journal Title
  
  Mol. Biol. Cell 17
  
  Pages: 2524-2536
- Data Source
  KAKENHI-PROJECT-16390085
[Journal Article] Nuclear RanGAP is required for the heterochromatin assembly and is repiprocally regulated by histone H3 and Clr4 histone methyltrans-ferase in Schizosaccharomyces pombe.2006
- Author(s)
  Nishijima, H.
- Journal Title
  
  Mol.Biol.Cell (in press)
- Data Source
  KAKENHI-PROJECT-17026036
[Journal Article] Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombe.2006
- Author(s)
  Nishijima, H., Nakayama, JI., Yoshioka, T., Kusano, A., Nishitani, H., Shibahara, K-i., Nishimoto, T.
- Journal Title
  
  Mol. Biol. Cell 17
  
  Pages: 2524-2536
- Data Source
  KAKENHI-PROJECT-17026036
[Patent] 標的組換え細胞とランダム組換え細胞を判別する方法およびその用途2007
- Inventor(s)
  柴原慶一, 西嶋仁, 国田嘉元
- Industrial Property Rights Holder
  情報・システム研究機構
- Industrial Property Number
  2007-011971
- Filing Date
  2007-04-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390085
[Patent] 標的組換え細胞とランダム組換え細胞を判別する方法及びその用途2006
- Inventor(s)
  柴原慶一, 西嶋仁, 国田嘉元
- Industrial Property Number
  2007-011971
- Filing Date
  2006-04-27
- Data Source
  KAKENHI-PROJECT-17026036
[Patent] 標的組換え細胞とランダム組換え細胞を判別する方法およびその用途2006
- Inventor(s)
  柴原慶一, 西嶋仁, 国田嘉元
- Industrial Property Number
  2007-011971
- Filing Date
  2006-04-27
- Data Source
  KAKENHI-PROJECT-16390085
[Presentation] PD-1-mediated suppression of CAR-T cells via CAR signalosomes colocalized by PD-12024
- Author(s)
  Yosuke Yoshida、Hiroaki Machiyama、Ei Wakamatsu、Arata Takeuchi、Hitoshi Nishijima、Tetsushi Nishikawa、Ryohei Matsushima、Masae Furuhata、Hiroko Toyota、Mamonkin Maksim、Brenner Malcolm K、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] 超解像イメージングが解明する免疫チェックポイント阻害療法の分子メカニズム2024
- Author(s)
  横須賀忠、西航、松島遼平、西川哲史、吉田洋輔、竹原朋宏、西嶋仁、町山裕亮、若松英、竹内新
- Organizer
  第51回日本集中治療医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] CD4/CD8 coreceptor binding to MHCs positively regulate CAR-T cell response via translocation of Lck into CAR microclusters2024
- Author(s)
  Hiroaki Machiyama、Ei Wakamatsu、Arata Takeuchi、Hitoshi Nishijima、Tetsushi Nishikawa、Ryohei Matsushima、Yosuke Yoshida、Masae Furuhata、Hiroko Toyota、Mamonkin Maksim、Brenner Malcolm K、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] c-SMAC formation in double positive T cells functions as a checkpoint in thymic selection2024
- Author(s)
  Hitoshi Nishijima、Ei Wakamatsu、Hiroaki Machiyama、Arata Takeuchi、Tetsushi Nishikawa、Yosuke Yoshida、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] Thymic T cell selection based on molecular imaging2024
- Author(s)
  Hitoshi Nishijima
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-22K08487
[Presentation] Comparison of linear and parallel co-stimulatory signaling via CD28 in the activation of Chimeric Antigen Receptor T Cells2024
- Author(s)
  Tetsushi Nishikawa、Arata Takeuchi、Hiroaki Machiyama、Ei Wakamatsu、Hitoshi Nishijima、Masae Furuhata、Hiroko Toyota、Nishi Wataru、Ryohei Matsushima、Yosuke Yoshida、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] Fine tuning of T cell activation by multistep regulation of CD6 and its ligand CD1662024
- Author(s)
  Arata Takeuchi、Tetsushi Nishikawa、Hiroaki Machiyama、Ei Wakamatsu、Hitoshi Nishijima、Masae Furuhata、Hiroko Toyota、Ryohei Matsushima、Yosuke Yoshida、Tadashi Yokosuka
- Organizer
  第52回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] Super-resolution imaging elucidates the molecular mechanism of CAR-T cells and ICI immunotherapy2023
- Author(s)
  横須賀忠、若松英、西嶋仁、竹内新、松島遼平、西航、西川哲史、吉田洋輔、Maksim Mamokin、Malcolm K Brenner、町山裕亮
- Organizer
  第85回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] 分子イメージングシステムを用いた補助刺激受容体2B4のT細胞におけるスイッチング機構の解明とCAR-T細胞への応用2023
- Author(s)
  松島遼平、若松英、齋藤顕昇、吉田洋輔、西川哲史、西航、豊田博子、古畑昌枝、町山裕亮、西嶋仁、竹内新、鈴木実、横須賀忠
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] 免疫チェックポイント阻害剤の効果に影響するヒトPD-1変異の解析2023
- Author(s)
  西航、若松英、町山裕亮、松島遼平、西川哲史、吉田洋輔、豊田博子、古畑昌枝、西嶋仁、竹内新、池田公英、鈴木実、横須賀忠
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] キメラ抗原受容体CAR-T細胞の初期の活性化と細胞応答におけるLckの分子動態と共受容体の関与2023
- Author(s)
  町山裕亮、若松英、西嶋仁、竹内新、横須賀忠
- Organizer
  第32回京都T細胞カンファレンス
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] ヒトPD-1マイクロクラスターの1分子イメージングを用いた治療用抗PD-1/PD-L1抗体の機能評価の研究2023
- Author(s)
  横須賀忠、西航、若松英、町山裕亮、松島遼平、吉田洋輔、西川哲史、竹原朋宏、西嶋仁、竹内新、東みゆき、鈴木実
- Organizer
  第26回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K27466
[Presentation] Tissue-specific autoimmunity controlled by Aire, a gene response for APECED2021
- Author(s)
  Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto
- Organizer
  The Virtual World Conference on Rare Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03699
[Presentation] Antigen transfer from thymic epithelial cells to DCs contributes to the production of thymic Tregs2019
- Author(s)
  Junko Morimoto, Hitoshi Nishijima, Minoru Matsumoto, Mitsuru Matsumoto
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03699
[Presentation] Aireを高発現する胸腺髄質上皮細胞の免疫学的機能とトランスクリプトーム解析2019
- Author(s)
  西嶋　仁、杉田瑞季、森本純子、松本　穣、松本　満
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19H03699
[Presentation] Aireを高発現する胸腺髄質上皮細胞の免疫学的機能とトランスクリプトーム解析2019
- Author(s)
  Nishijima Hitoshi, Sugita Mizuki, Morimoto Junko, Matsumoto Minoru, Matsumoto Mitsuru
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Aireを高発現する胸腺髄質上皮細胞の免疫学的機能とトランスクリプトーム解析2019
- Author(s)
  西嶋　仁、杉田瑞季、森本純子、松本　穣、松本　満
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K19564
[Presentation] Aire-dependent establishment of self-tolerance studied by genetically modified mice2019
- Author(s)
  Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Ryuichiro Miyazawa, Hitoshi Nishijima
- Organizer
  EMBO Workshop ThymE
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03699
[Presentation] Characterization of Aire-expressing DCs with a high-sensitivity and high-fidelity Aire-reporter strain2019
- Author(s)
  Minoru Matsumoto, Hitoshi Nishijima, Ryuichiro Miyazawa, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19564
[Presentation] Aire-dependent establishment of self-tolerance2019
- Author(s)
  Matsumoto M, Morimoto J, Matsumoto M, Tsuneyama K, Miyazawa R, Nishijima H
- Organizer
  The 17th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19564
[Presentation] Aire-dependent establishment of self-tolerance2019
- Author(s)
  Matsumoto M, Morimoto J, Matsumoto M, Tsuneyama K, Miyazawa R, Nishijima H
- Organizer
  The 17th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03699
[Presentation] Aire-dependent establishment of self-tolerance studied by genetically modified mice2019
- Author(s)
  Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Ryuichiro Miyazawa, Hitoshi Nishijima
- Organizer
  EMBO Workshop ThymE
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19564
[Presentation] Characterization of Aire-expressing DCs with a high-sensitivity and high-fidelity Aire-reporter strain2019
- Author(s)
  Minoru Matsumoto, Hitoshi Nishijima, Ryuichiro Miyazawa, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03699
[Presentation] Aire-dependent establishment of self-tolerance studied by genetically modified mice.2019
- Author(s)
  Matsumoto Mitsuru, Morimoto Junko, Matsumoto Minoru, Tsuneyama Koichi, Miyazawa Ryuichiro, Nishijima Hitoshi
- Organizer
  EMBO Workshop ThymE
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Aire-dependent establishment of self-tolerance2019
- Author(s)
  Matsumoto Mitsuru, Morimoto Junko, Matsumoto Minoru, Tsuneyama Koichi, Miyazawa Ryuichiro, Nishijima Hitoshi
- Organizer
  The 17th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Antigen transfer from thymic epithelial cells to DCs contributes to the production of thymic Tregs2019
- Author(s)
  Junko Morimoto, Hitoshi Nishijima, Minoru Matsumoto, Mitsuru Matsumoto
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K19564
[Presentation] A novel Aire-dependent subset of mTECs with tolerogenic functions is defined by Ly6 family protein expression2018
- Author(s)
  Mitsuru Matsumoto, Junko Morimoto, Minoru Matsumoto, Koichi Tsuneyama, Hitoshi Nishijima
- Organizer
  ThymOz8
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] Acquisition of the resistance to autoimmune diabetes by the expression of human AIRE in BM-derived APCs in NOD2018
- Author(s)
  Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama, Mitsuru Matsumoto
- Organizer
  ThymOz8
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] A novel Aire-dependent subset of mTECs with tolerogenic functions is defined by Ly6 family protein expression2018
- Author(s)
  Matsumoto Mitsuru、Morimoto Junko、Matsumoto Minoru、 Tsuneyama Koichi、Nishijima Hitoshi
- Organizer
  ThymOz8
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells2018
- Author(s)
  Morimoto Junko、Nishikawa Yumiko、Kihara Naoki、Hosomichi Kazuyoshi、Nishijima Hitoshi、Matsumoto Mitsuru
- Organizer
  Immunology 2018 - AAI Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Transgenic human AIRE expression in peripheral antigen-presenting cells resulted in the acquisition of the resistance to the diabetes in NOD2018
- Author(s)
  Mitsuru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Minoru Matsumoto
- Organizer
  20th Global Congress on Biotechnology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] Manipulation of thymic and peripheral tolerance by AIRE defines distinct tissue-specific autoimmunity2018
- Author(s)
  Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto
- Organizer
  11th International Congress on Autoimmunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19564
[Presentation] Manipulation of thymic and peripheral tolerance by AIRE defines distinct tissue-specific autoimmunity2018
- Author(s)
  Matsumoto Minoru、Nishijima Hitoshi、Morimoto Junko、Tsuneyama Koichi、Matsumoto Mitsuru
- Organizer
  11th International Congress on Autoimmunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Manipulation of thymic and peripheral tolerance by AIRE defines distinct tissue-specific autoimmunity2018
- Author(s)
  Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto
- Organizer
  11th International Congress on Autoimmunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] Transcriptomic analysis of medullary thymic epithelial cells with augmented Aire expression2018
- Author(s)
  Nishijima Hitoshi、Morimoto Junko、Matsumoto Minoru、Matsumoto Mitsuru
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] 胸腺髄質上皮細胞におけるAire発現レベルと組織特異的自己抗原遺伝子発現との関連性に関する検討2018
- Author(s)
  Nishijima Hitoshi、Morimoto Junko、Matsumoto Minoru、Matsumoto Mitsuru
- Organizer
  28 Kyoto T cell Conference (KTCC)
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells2018
- Author(s)
  Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima, Mitsuru Matsumoto
- Organizer
  Immunology 2018 - AAI Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19564
[Presentation] Distinct tissue-specific immune response revealed by manipulation of thymic and peripheral tolerance by Aire2018
- Author(s)
  Matsumoto Minoru、Nishijima Hitoshi、Morimoto Junko、Matsumoto Mitsuru
- Organizer
  1st International Symposium for "Neo-self"
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Acquisition of the resistance to autoimmune diabetes by the expression of human AIRE in BM-derived APCs in NOD2018
- Author(s)
  Matsumoto Minoru、Nishijima Hitoshi、Morimoto Junko、Tsuneyama Koichi、Matsumoto Mitsuru
- Organizer
  ThymOz8
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Analysis of the role of thymic APCs and Aire in the production of thymic Tregs2018
- Author(s)
  Morimoto Junko、Nishijima Hitoshi、Matsumoto Minoru、Matsumoto Mitsuru
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells2018
- Author(s)
  Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima, Mitsuru Matsumoto
- Organizer
  Immunology 2018 - AAI Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] "Transgenic human AIRE expression in NOD acquired resistance to T1D due to the impaired presentation of self-antigens"2017
- Author(s)
  Minoru Matsumoto, Hitoshi Nishijima, Junko Morimoto, Koichi Tsuneyama and Mitsuru Matsumoto
- Organizer
  第46回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function2017
- Author(s)
  Morimoto, J., Nishikawa, Y., Nishijima, H., Matsumoto, M.
- Organizer
  12th International Congress on SLE
- Place of Presentation
  Melbourne (Australia)
- Year and Date
  2017-03-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] Paradoxical development of polymyositis-like autoimmunity through augmented expression of AIRE2017
- Author(s)
  Hitoshi Nishijima, Yasuhiro Mouri, Jyunko Morimoto, Mitsuru Matsumoto
- Organizer
  7th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  芝蘭会館（京都府・京都市）
- Year and Date
  2017-03-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] ヒトAIRE トランスジェニックマウスに誘導される多発性筋炎病態の解析2017
- Author(s)
  Hitoshi Nishijima, Yoshiki Matsuoka, Yasuhiro Mouri, Jyunko Morimoto, Mitsuru Matsumoto
- Organizer
  第36回日本胸腺研究会
- Place of Presentation
  芝蘭会館（京都府・京都市）
- Year and Date
  2017-02-04
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells2017
- Author(s)
  Morimoto Junko、Nishikawa Yumiko、Kihara Naoki、Hosomichi Kazuyoshi、Nishijima Hitoshi、Matsumoto Mitsuru
- Organizer
  5th Annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Paradoxical development of polymyositis-like autoimmunity through augmented expression of human AIRE in mice2017
- Author(s)
  Nishijima, H., Mouri, Y., Morimoto, J., Matsumoto, M.
- Organizer
  Controversies in Rheumatology and Autoimmunity 2017
- Place of Presentation
  Bologna (Italy)
- Year and Date
  2017-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] Paradoxical development of polymyositis-like autoimmunity through augmented expression of AIRE2017
- Author(s)
  Nishijima, H., Mouri, Y., Morimoto, J., Matsumoto, M.
- Organizer
  7th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  芝蘭会館（京都府・京都市）
- Year and Date
  2017-03-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] Transgenic human AIRE expression in NOD acquired resistance to the diabetes due to the impaired presentation of self-antigens in the pancreas2017
- Author(s)
  Matsumoto Minoru、Nishijima Hitoshi、Morimoto Junko、Tsuneyama Koichi、Matsumoto Mitsuru
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08885
[Presentation] Paradoxical development of polymyositis-like autoimmunity through augmented expression of human AIRE in mice2017
- Author(s)
  Hitoshi Nishijima, Yasuhiro Mouri, Jyunko Morimoto, Mitsuru Matsumoto
- Organizer
  Controversies in Rheumatology and Autoimmunity 2017
- Place of Presentation
  Bologna (Italy)
- Year and Date
  2017-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Expression of Ly6C/6G defines a novel subset of medullary thymic epithelial cells2017
- Author(s)
  Junko Morimoto, Yumiko Nishikawa, Naoki Kihara, Kazuyoshi Hosomichi, Hitoshi Nishijima, Mitsuru Matsumoto
- Organizer
  第5回国際サイトカイン・インターフェロン学会年会 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function2017
- Author(s)
  Jyunko Morimoto, Yumiko Nishikawa, Hitoshi Nishijima, Mitsuru Matsumoto
- Organizer
  12th International Congress on SLE
- Place of Presentation
  Melbourne (Australia)
- Year and Date
  2017-03-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Possible defect in the Treg production in mice overexpressing AIRE/Aire which exhibit muscle-specific autoimmunity2016
- Author(s)
  Hitoshi Nishijima, Yoshiki Matsuoka, Yasuhiro Mouri, Jyunko Morimoto, Mitsuru Matsumoto
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県・宜野湾市）
- Year and Date
  2016-12-06
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Massive infiltration of macrophages and eosinophils in the muscle of mice overexpressing Aire in thymic and peripheral antigen-presenting cells2016
- Author(s)
  Nishijima, H., Matsumoto, M.
- Organizer
  Cell Symposia
- Place of Presentation
  Sicily (Italy)
- Year and Date
  2016-09-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] Augmented expression of the autoimmune regulator (AIRE) induces paradoxical development of polymyositis-like autoimmunity2016
- Author(s)
  Hitoshi Nishijima, Mitsuru Matsumoto
- Organizer
  Immunology 2016
- Place of Presentation
  Seattle (USA)
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Augmented expression of the autoimmune regulator (AIRE) induces paradoxical development of polymyositis-like autoimmunity2016
- Author(s)
  Nishijima, H., Matsumoto, M.
- Organizer
  Immunology 2016
- Place of Presentation
  Seattle (USA)
- Year and Date
  2016-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] Massive infiltration of macrophages and eosinophils in the muscle of mice overexpressing Aire in thymic and peripheral antigen-presenting cells2016
- Author(s)
  Hitoshi Nishijima, Mitsuru Matsumoto
- Organizer
  Cell Symposia - 100 Years of Phagocytosis
- Place of Presentation
  Sicily (Italy)
- Year and Date
  2016-09-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Possible defect in the Treg production in mice overexpressing AIRE/Aire which exhibit muscle-specific autoimmunity2016
- Author(s)
  Nishijima, H., Matsuoka, Y., Mouri, Y., Morimoto, J., Matsumoto, M.
- Organizer
  第45回日本免疫学会総会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県・宜野湾市）
- Year and Date
  2016-12-06
- Data Source
  KAKENHI-PROJECT-16H05342
[Presentation] Aire expression is inherent properties of all medullary thymic epithelial cells during their differentiation program.2015
- Author(s)
  Mitsuru Matsumoto, Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Yasuhiko Nishioka
- Organizer
  Venice Thymus Meeting
- Place of Presentation
  Venice International University (Italy)
- Year and Date
  2015-04-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Paradoxical development of polymyositis-like autoimmunity by the additive expression of AIRE.2015
- Author(s)
  Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto, Hiroshi Kawano, and Mitsuru Matsumoto
- Organizer
  第44回日本免疫学会総会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] Paradoxical development of polymyositis-like autoimmunity by the additive expression of AIRE.2015
- Author(s)
  Hitoshi Nishijima, Yasuhiro Mouri, Junko Morimoto, Hiroshi Kawano, and Mitsuru Matsumoto
- Organizer
  第44回日本免疫学会総会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Aire expression is inherent to all medullary thymic epithelial cells during their differentiation program.2015
- Author(s)
  Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Mitsuru Matsumoto
- Organizer
  The 4th European Congress of Immunology
- Place of Presentation
  Vienna (Austria)
- Year and Date
  2015-09-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] Aire expression is inherent to all medullary thymic epithelial cells during their differentiation program.2015
- Author(s)
  Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Mitsuru Matsumoto
- Organizer
  The 4th European Congress of Immunology
- Place of Presentation
  Austria Center Vienna (Austria)
- Year and Date
  2015-09-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Aire expression is inherent properties of all medullary thymic epithelial cells during their differentiation program.2015
- Author(s)
  Mitsuru Matsumoto, Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Yasuhiro Mouri and Yasuhiko Nishioka
- Organizer
  Venice Thymus Meeting
- Place of Presentation
  Venice (Italy)
- Year and Date
  2015-04-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] A novel Aire-dependent subset of medullary thymic epithelial cells that express Ly6 family protein.2015
- Author(s)
  Junko Morimoto, Yumiko Nishikawa, Hiroshi Kawano, Yasuhiro Mouri, Hitoshi Nishijima, and Mitsuru Matsumoto
- Organizer
  第44回日本免疫学会総会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] A novel Aire-dependent subset of medullary thymic epithelial cells that express Ly6 family protein.2015
- Author(s)
  Junko Morimoto, Yumiko Nishikawa, Hiroshi Kawano, Yasuhiro Mouri, Hitoshi Nishijima, and Mitsuru Matsumoto
- Organizer
  第44回日本免疫学会総会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their full maturation program2013
- Author(s)
  Nishikawa, Y., Mouri, Y., Nishijima, H., Matsumoto, M.
- Organizer
  Controversies in Rheumatology and Autoimmunity
- Place of Presentation
  Hotel Novotel Budapest City（Hungary）
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] Temporal fate-mapping study reveals essential roles of Aire in the maturation program of Aire-expressing cell lineage2013
- Author(s)
  Matsumoto, M., Nishikawa, Y., Mouri, Y., Nishijima, H
- Organizer
  IMMUNOLOGY 2013-AAI Annual Meeting
- Place of Presentation
  Hawaii Convention Center (USA)
- Year and Date
  2013-05-03
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program2013
- Author(s)
  Matsumoto, M., Nishikawa, Y., Nishijima, H., Matsumoto, M., Morimoto, J., Hirota, F., Takahashi, S., Luche, H., Fehling, H.J., Mouri, Y.
- Organizer
  The 6th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  芝蘭会館（京都府）
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance2013
- Author(s)
  Nishijima, H, Morimoto, J, Mouri, Y, Nishikawa, Y, Ikuta, K, Matsumoto, M
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張メッセ(千葉県千葉市)
- Year and Date
  2013-12-11
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化2013
- Author(s)
  西嶋　仁、毛利安宏、西川裕美子、松本　満
- Organizer
  第54回日本生化学中国・四国支部例会
- Place of Presentation
  徳島大学大塚講堂（徳島県）
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] Temporal fate-mapping study reveals essential roles of Aire in the maturation program of Aire-expressing cell lineage2013
- Author(s)
  Matsumoto, M., Nishikawa, Y., Mouri, Y., Nishijima, H.
- Organizer
  IMMUNOLOGY 2013-AAI Annual Meeting
- Place of Presentation
  Hawaii Convention Center（USA）
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化2013
- Author(s)
  西嶋仁、毛利安宏、西川裕美子、松本満
- Organizer
  第54回日本生化学中国・四国支部例会
- Place of Presentation
  徳島大学大塚講堂(徳島県徳島市)
- Year and Date
  2013-05-31
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their full maturation program2013
- Author(s)
  Nishikawa, Y., Mouri, Y., Nishijima, H., Matsumoto, M.
- Organizer
  Controversies in Rheumatology and Autoimmunity
- Place of Presentation
  Hotel Novotel Budapest City（Hungary）
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their full maturation program2013
- Author(s)
  Nishikawa, Y., Mouri, Y., Nishijima, H., Matsumoto, M
- Organizer
  Controversies in Rheumatology and Autoimmunity
- Place of Presentation
  Hotel Novotel Budapest City (Hungary)
- Year and Date
  2013-04-04
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program2013
- Author(s)
  Matsumoto, M., Nishikawa, Y., Nishijima, H., Matsumoto, M., Hirota, F., Takahashi, S., Luche, H., Fehling, H.S., Mouri, Y
- Organizer
  The 6^<th> International Workshop of Kyoto T Cell Conference
- Place of Presentation
  Shiran-Kaikan (Kyoto)
- Year and Date
  2013-06-03
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Temporal fate-mapping study reveals essential roles of Aire in the maturation program of Aire-expressing cell lineage2013
- Author(s)
  Matsumoto, M., Nishikawa, Y., Mouri, Y., Nishijima, H.
- Organizer
  IMMUNOLOGY 2013-AAI Annual Meeting
- Place of Presentation
  Hawaii Convention Center（USA）
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化2013
- Author(s)
  西嶋　仁、毛利安宏、西川裕美子、松本　満
- Organizer
  第54回日本生化学中国・四国支部例会
- Place of Presentation
  徳島大学大塚講堂（徳島県）
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their maturation program2013
- Author(s)
  Matsumoto, M., Nishikawa, Y., Mouri, Y., Nishijima, H
- Organizer
  15^<th> ICI2013
- Place of Presentation
  MiCo Milano Congressi (Italy)
- Year and Date
  2013-08-27
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program2013
- Author(s)
  Matsumoto, M., Nishikawa, Y., Nishijima, H., Matsumoto, M., Morimoto, J., Hirota, F., Takahashi, S., Luche, H., Fehling, H.J., Mouri, Y.
- Organizer
  The 6th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  芝蘭会館（京都府）
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] ire controls organization of thymic microenvironment for the establishment of self tolerance2012
- Author(s)
  Matsumoto, M., Nishikawa, Y., Mouri, Y., Nishijima, H
- Organizer
  European Congress of Immunology 2012
- Place of Presentation
  Scottish Exhibition & Conference Center (Scotland)
- Year and Date
  2012-09-05
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Temporal fate- mapping reveals essential roles of Aire in the maturation program of mTECs2012
- Author(s)
  Matsumoto, M., Nishikawa, Y., Mouri, Y., Hirota, F., Nishijima, H
- Organizer
  ThymUS 2012
- Place of Presentation
  Trump International Beach Resort (USA)
- Year and Date
  2012-11-04
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] 遺伝性自己免疫疾患の原因遺伝子AIREを導入したHeLa細胞における細胞周期依存的AIREタンパク質のリン酸化2012
- Author(s)
  西嶋　仁
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化2011
- Author(s)
  西嶋　仁
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  幕張メッセ（千葉）
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] 遺伝性自己免疫疾患の原因遺伝子AIREを導入したHeLa細胞における細胞周期依存的AIREタンパク質のリン酸化2011
- Author(s)
  西嶋仁、松本満
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場(福岡県福岡市)
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Negative selectionにおけるAire発現細胞由来自己抗原の役割2011
- Author(s)
  毛利安宏、西川裕美子、西嶋仁、松本満
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  幕張メッセ(千葉県千葉市)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] AIRE遺伝子を導入したHeLa細胞における細胞周期依存的なAIREタンパク質のリン酸化2011
- Author(s)
  西嶋仁、毛利安宏、西川裕美子、松本満
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  幕張メッセ(千葉県千葉市)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance
- Author(s)
  Nishijima, H., Morimoto, J., Mouri, Y., Nishikawa, Y., Ikuta, K., Matsumoto, M.
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張メッセ（千葉県）
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their maturation program
- Author(s)
  Matsumoto, M., Nishikawa, Y., Mouri, Y., Nishijima, H.
- Organizer
  15th ICI2013
- Place of Presentation
  MiCo Milano Congressi（Italy）
- Data Source
  KAKENHI-PROJECT-23591437
[Presentation] Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance
- Author(s)
  Nishijima, H., Morimoto, J., Mouri, Y., Nishikawa, Y., Ikuta, K., Matsumoto, M.
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張メッセ（千葉県）
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] Approaches to identify Aire-regulated non-tissue-restricted antigen genes by the ectopic expression of Aire in thymic cortex
- Author(s)
  Nishijima, H., Morimoto, J., Mouri, Y., Kawano, H., Ikuta, K., Matsumoto, M.
- Organizer
  第43回日本免疫学会総会
- Place of Presentation
  京都国際会議場（京都府・京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Unexpected disturbance of the development of medullary thymic epithelial cells at immature stages by the long-term ablation of mature Aire-expressing cells
- Author(s)
  Kawano, H., Morimoto, J., Mouri, Y., Nishijima, H., Nishioka, Y., Matsumoto, M.
- Organizer
  第43回日本免疫学会総会
- Place of Presentation
  京都国際会議場（京都府・京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] Approaches to identify Aire-regulated non-tissue-restricted antigen genes by the ectopic expression of Aire in thymic cortex
- Author(s)
  Nishijima, H., Morimoto, J., Mouri, Y., Kawano, H., Ikuta, K., Matsumoto, M.
- Organizer
  第43回日本免疫学会総会
- Place of Presentation
  京都国際会議場（京都府・京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary thymic microenvironment
- Author(s)
  Nishijima, H., Morimoto, J., Kawano, H., Mouri, Y., Ikuta, K., Matsumoto, M.
- Organizer
  ThymOz 7
- Place of Presentation
  Heron Island (Australia)
- Year and Date
  2014-04-02 – 2014-04-07
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] 胸腺皮質上皮細胞への異所性発現による Aire の機能解析
- Author(s)
  西嶋　仁、生田宏一、松本　満
- Organizer
  第24回 Kyoto T Cell Conference
- Place of Presentation
  京都平安ホテル（京都府・京都市）
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] Temporal lineage tracing of Aire-expressing cells reveals a requirement of Aire for their maturation program
- Author(s)
  Matsumoto, M., Nishikawa, Y., Mouri, Y., Nishijima, H.
- Organizer
  15th ICI2013
- Place of Presentation
  MiCo Milano Congressi（Italy）
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] Unexpected disturbance of the development of medullary thymic epithelial cells at immature stages by the long-term ablation of mature Aire-expressing cells
- Author(s)
  Kawano, H., Morimoto, J., Mouri, Y., Nishijima, H., Nishioka, Y., Matsumoto, M.
- Organizer
  第43回日本免疫学会総会
- Place of Presentation
  京都国際会議場（京都府・京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a stromal factor for medullary thymic microenvironment
- Author(s)
  Nishijima, H., Morimoto, J., Kawano, H., Mouri, Y., Ikuta, K., Matsumoto, M.
- Organizer
  ThymOz 7
- Place of Presentation
  Heron Island (Australia)
- Year and Date
  2014-04-02 – 2014-04-07
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a medullary stromal factor
- Author(s)
  Matsumoto, M., Nishijima, H.
- Organizer
  European Society for Immunodeficiencies 2014
- Place of Presentation
  Prague Congress Centre (Czech Republic)
- Year and Date
  2014-10-29 – 2014-11-01
- Data Source
  KAKENHI-PROJECT-26461464
[Presentation] Ectopic Aire expression in thymic cortex reveals inherent properties of Aire as a medullary stromal factor
- Author(s)
  Matsumoto, M., Nishijima, H.
- Organizer
  European Society for Immunodeficiencies 2014
- Place of Presentation
  Prague Congress Centre (Prague, Czech Republic)
- Year and Date
  2014-10-29 – 2014-11-01
- Data Source
  KAKENHI-PROJECT-25293223
[Presentation] 胸腺皮質上皮細胞への異所性発現による Aire の機能解析
- Author(s)
  西嶋　仁、生田宏一、松本　満
- Organizer
  第24回 Kyoto T Cell Conference
- Place of Presentation
  京都平安ホテル（京都府・京都市）
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26461464

1. MATSUMOTO Mitsuru (60221595)

# of Collaborated Projects: 6 results

# of Collaborated Products: 80 results
2. 森本純子 (20451396)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
3. SHIBAHARA Kei-ichi (20263098)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. ONO Tatsuya (50419850)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. MOURI Yasuhiro (80464353)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
6. 横須賀忠 (10359599)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
7. OGAWA Yuya (10370123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 松本穣 (30836250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
9. 竹内新 (00360579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
10. 若松英 (40632617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
11. 町山裕亮 (40704606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
12. 増田清士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 常山幸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishijima Hitoshi 西嶋 仁

NISHIJIMA Hitoshi 西嶋 仁

Research Projects

Research Products

Co-Researchers

新規ヒトCD３ε発現マウスモデルを用いた二重特異性抗体の時空間的機能解析Principal Investigator

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Development of the basis of the crosstalk between T cell costimulatory receptors and chimeric antigen receptors

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先端的分子イメージング法を基盤としたBiTE抗体療法の解析Principal Investigator

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Elucidation of the pathogenesis of autoimmune diseases based on AIRE and development of novel therapies for the autoimmune diseases

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Studies on the mechanisms underlying autoimmune ambivalence

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Analysis of AIRE-dependent gene-expression network which controls the differentiation of mTECsPrincipal Investigator

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Elucidation of the pathogenesis of autoimmune disease through the functional study of AIRE

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Studies on the mechanisms for autoimmune phenotype in disease model mousePrincipal Investigator

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Studies aiming the establishing self-tolerance for the cure of autoimmune disease

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Studies on the mechanisms for the prevention of diabetes in NOD mice by AIRE expressionPrincipal Investigator

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DDM1によるヘテロクロマチン形成にRNA分子が関与する可能性

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Chromatin replication through cellular proliferation in eukaryotic cells

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[Book] Basic Immunology and Its Clinical Application2024

Author(s)

Total Pages

Nishijima Hitoshi 西嶋仁

NISHIJIMA Hitoshi 西嶋仁