TAKASUGI NOBUMASA 高杉展正

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TAKASUGI Nobumasa 高杉展正

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Researcher Number	60436590
Other IDs	https://orcid.org/0000-0002-6059-2082
Affiliation (Current)	2025: 岡山大学, 医歯薬学域, 准教授 2025: 順天堂大学, 医学部, 非常勤助教
Affiliation (based on the past Project Information) *help	2025: 岡山大学, 医歯薬学域, 准教授 2021 – 2023: 岡山大学, 医歯薬学域, 准教授 2016 – 2023: 岡山大学, 医歯薬学総合研究科, 准教授 2015: 岡山大学, 医歯(薬)学総合研究科, 准教授 2014: 順天堂大学, 医学部, 助教 … More 2010: The University of Tokyo, 医学(系)研究科(研究院), 助教 2009: The University of Tokyo, 大学院・医学系研究科, 助教 2008: The University of Tokyo, 大学院・薬学系研究科, 助教 2008: The University of Tokyo, 大学院薬学系研究科, 助教 2007: The University of Tokyo, 大学院・薬学系研究科, 研究員 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Nerve anatomy/Neuropathology Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 46020:Anatomy and histopathology of nervous system-related / Nerve anatomy/Neuropathology
Keywords	Principal Investigator アルツハイマー病 / アミロイドβ / Aβ / 小胞輸送障害 / 小胞輸送 / リピッドフリッパーゼ / スフィンゴシン-1-リン酸 / スフィンゴシンキナーゼ / APP / アミロイド仮説 … More / C99 / 脂質輸送酵素 / βCTF / 神経変性疾患 / アルツハイマー / Amyloid-beta / Sphingosine-1-phosphate / Sphingosine kinase / アストロサイト / スフィンゴシン-１-リン酸 / アポリポプロテインE / 脂質代謝酵素 / SphK2 / S1P / βアミロイド / βセクレターゼ / RNA interference / NOTCH / RNA干渉法 / Notch / γセクレターゼ … More Except Principal Investigator アルツハイマー病 / アミロイドβ / アミロイドプラーク / 神経変性疾患 / 神経変性突起 / アミロイドベータ / ライブセル・イメージング / GABAB受容体 / シナプス / GABA / 海馬 / 神経伝達 / Gタンパク質共役型受容体 / アミロイド / 膜タンパク質 / 器官培養 / 老人斑 / シナプス可塑性 / GABA受容体 / 代謝型グルタミン酸受容体 / GPCR / 軸索輸送 / アルツハイマー / amyloid beta / Alzheimer's disease / Amyloid beta / APP / BACE1 / 輸送障害 / 変性神経突起 / 痴呆 / 脂質 / 認知症 / 脳神経疾患 Less

Challenge to develop a multifunctional treatment for Alzheimer's disease based on the amyloid and traffic jam hypotheses.Principal Investigator
- Principal Investigator
  
  高杉展正
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Okayama University
変性神経突起における輸送障害とアルツハイマー病初期病態進展機序の解明
- Principal Investigator
  
  樫山拓
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
Establishing quantitative and comprehensive methods for analyzing vesicular traffic impairment to identify the drug candidates for Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  TAKASUGI NOBUMASA
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Okayama University
GPCR-Amyloid precursor protein supercomplex regulate neural function
- Principal Investigator
  
  Kamikubo Yuji
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
APP-BACE1結合仲介分子によるアミロイドβ産生制御機構の解明
- Principal Investigator
  
  樫山拓
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Juntendo University
Lipid flippase is the novel therapeutic target for the Alzheimer disease, which correlate with endocytic traffic impairment.Principal Investigator
- Principal Investigator
  
  TAKASUGI NOBUMASA
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Okayama University
Simultaneous control of the production and degradation of Amyloid be-ta by Sphingosine kinase/sphingosine-1-phosphate signalingPrincipal Investigator
- Principal Investigator
  
  TAKASUGI NOBUMASA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Okayama University
  Juntendo University
Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairment
- Principal Investigator
  
  SAKURAI Takashi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Juntendo University
SPHK/S1Pシグナリングによるβセクレターゼ制御機構の解析Principal Investigator
- Principal Investigator
  
  高杉展正
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Substrate specific modulation of the ....secretase activity by vesicular traffickingPrincipal Investigator
- Principal Investigator
  
  TAKASUGI Nobumasa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo

[Journal Article] Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes2024
- Author(s)
  Komai Masato、Noda Yuka、Ikeda Atsuya、Kaneshiro Nanaka、Kamikubo Yuji、Sakurai Takashi、Uehara Takashi、Takasugi Nobumasa
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 65 Issue: 3 Pages: 100510-100510
- DOI
  10.1016/j.jlr.2024.100510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06170, KAKENHI-PROJECT-20K07765, KAKENHI-PROJECT-23KJ1603, KAKENHI-PROJECT-21H02815
[Journal Article] The Pursuit of the “Inside” of the Amyloid Hypothesis?Is C99 a Promising Therapeutic Target for Alzheimer’s Disease?2023
- Author(s)
  Takasugi Nobumasa、Komai Masato、Kaneshiro Nanaka、Ikeda Atsuya、Kamikubo Yuji、Uehara Takashi
- Journal Title
  
  Cells
  
  Volume: 12 Issue: 3 Pages: 454-454
- DOI
  10.3390/cells12030454
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07765, KAKENHI-PROJECT-20K07014
[Journal Article] Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage2023
- Author(s)
  Kamikubo Yuji、Jin Hao、Zhou Yiyao、Niisato Kazue、Hashimoto Yoshie、Takasugi Nobumasa、Sakurai Takashi
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 15 Pages: 1068990-1068990
- DOI
  10.3389/fnmol.2022.1068990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02815, KAKENHI-PROJECT-20K07014, KAKENHI-PROJECT-23K06170, KAKENHI-PROJECT-20K07765
[Journal Article] Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease2022
- Author(s)
  Kaneshiro Nanaka、Komai Masato、Imaoka Ryosuke、Ikeda Atsuya、Kamikubo Yuji、Saito Takashi、Saido Takaomi C.、Tomita Taisuke、Hashimoto Tadafumi、Iwatsubo Takeshi、Sakurai Takashi、Uehara Takashi、Takasugi Nobumasa
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 3 Pages: 103869-103869
- DOI
  10.1016/j.isci.2022.103869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21H02815, KAKENHI-PROJECT-19J22442, KAKENHI-PROJECT-20K07014, KAKENHI-PROJECT-20K07765, KAKENHI-PROJECT-21K07270
[Journal Article] Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain2022
- Author(s)
  Nomura Ryosuke、Takasugi Nobumasa、Hiraoka Hideki、Iijima Yuta、Iwawaki Takao、Kumagai Yoshito、Fujimura Masatake、Uehara Takashi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 23 Pages: 15412-15412
- DOI
  10.3390/ijms232315412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-20K07014
[Journal Article] Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor2021
- Author(s)
  Nakahara Kengo、Hamada Kyohei、Tsuchida Tomoki、Takasugi Nobumasa、Abiko Yumi、Shien Kazuhiko、Toyooka Shinichi、Kumagai Yoshito、Uehara Takashi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 296 Pages: 100524-100524
- DOI
  10.1016/j.jbc.2021.100524
- NAID
  120007116763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-19K22498, KAKENHI-PROJECT-20K07014
[Journal Article] Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain.2021
- Author(s)
  Hiraoka, H., Nomura, R., Takasugi, N., Akai, R., Iwawaki, T., Kumagai, Y., Fujimura, M., and Uehara, T.
- Journal Title
  
  Arch. Toxicol.
  
  Volume: 95 Issue: 4 Pages: 1241-1250
- DOI
  10.1007/s00204-021-02982-9
- NAID
  120007185542
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-20J11445, KAKENHI-PROJECT-19K22498, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-20K07014
[Journal Article] S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein2020
- Author(s)
  Fujikawa Kana、Nakahara Kengo、Takasugi Nobumasa、Nishiya Tadashi、Ito Akihiro、Uchida Koji、Uehara Takashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 4 Pages: 910-915
- DOI
  10.1016/j.bbrc.2020.02.011
- NAID
  120006956819
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-20J21060, KAKENHI-PROJECT-19K22498, KAKENHI-PROJECT-17H06170
[Journal Article] Attenuation of Macrophage Migration Inhibitory Factor-Stimulated Signaling <i>via</i> <i>S</i>-Nitrosylation2019
- Author(s)
  Nakahara Kengo、Fujikawa Kana、Hiraoka Hideki、Miyazaki Ikuko、Asanuma Masato、Ito Akihiro、Takasugi Nobumasa、Uehara Takashi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 6 Pages: 1044-1047
- DOI
  10.1248/bpb.b19-00025
- NAID
  130007657685
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-06-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07993, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-18H05293
[Journal Article] Emerging role of electrophiles as a key regulator for endoplasmic reticulum (ER) stress.2019
- Author(s)
  Takasugi, N., Hiraoka, H., Nakahara, K., Akiyama, S., Fujikawa, K., Nomura, R., Furuichi, M., and Uehara, T.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 20(7) Issue: 7 Pages: 1783-1783
- DOI
  10.3390/ijms20071783
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19490, KAKENHI-PROJECT-19K22498, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-17H06170
[Journal Article] Functional analysis of juxta- and intra-membrane domains of murine APP by genome editing in Neuro2a cells2018
- Author(s)
  Kaneshiro Nanaka、Imaoka Ryosuke、Komai Masato、Kashiyama Taku、Sakurai Takashi、Uehara Takashi、Takasugi Nobumasa
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 501 Issue: 4 Pages: 1023-1028
- DOI
  10.1016/j.bbrc.2018.05.102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-16H04667
[Journal Article] TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes2018
- Author(s)
  Takasugi Nobumasa、Araya Runa、Kamikubo Yuji、Kaneshiro Nanaka、Imaoka Ryosuke、Jin Hao、Kashiyama Taku、Hashimoto Yoshie、Kurosawa Masaru、Uehara Takashi、Nukina Nobuyuki、Sakurai Takashi
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 8 Pages: 0200988-0200988
- DOI
  10.1371/journal.pone.0200988
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-17K09040, KAKENHI-PROJECT-17H01564, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-18H00446
[Journal Article] Consecutive Analysis of BACE1 Function on Developing and Developed Neuronal Cells2017
- Author(s)
  Kamikubo Y, Takasugi N, Niisato K, Hashimoto Y, Sakurai T
- Journal Title
  
  J Alzheimers Diｓ
  
  Volume: 56 Issue: 2 Pages: 641-653
- DOI
  10.3233/jad-160806
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-26430059, KAKENHI-PROJECT-26460707, KAKENHI-PROJECT-17K09040
[Journal Article] Modulation of Unfolded Protein Response by Methylmercury2017
- Author(s)
  Hiraoka H, Nakahara K, Kaneko Y, Akiyama S, Okuda K, Iwawaki T, Fujimura M, Kumagai Y, Takasugi N, Uehara T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 9 Pages: 1595-1598
- DOI
  10.1248/bpb.b17-00359
- NAID
  130006038778
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H04649, KAKENHI-PROJECT-16J00339
[Journal Article] Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity.2014
- Author(s)
  Nobumasa Takasugi; Tomoki Sasaki; Mitsuru Shinohara; Takeshi Iwatsubo; Taisuke Tomita
- Journal Title
  
  Biochemical and biophysical research communications.
  
  Volume: 457 Issue: 2 Pages: 194-199
- DOI
  10.1016/j.bbrc.2014.12.087
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430059
[Patent] アルツハイマー病予防治療薬のスクリーニング法2014
- Inventor(s)
  高杉　展正、　櫻井　隆、　清水　瑠奈
- Industrial Property Rights Holder
  高杉　展正、　櫻井　隆、　清水　瑠奈
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-132309
- Filing Date
  2014-06-17
- Data Source
  KAKENHI-PROJECT-26430059
[Patent] 特許権2014
- Inventor(s)
  高杉展正、新家瑠奈、櫻井隆
- Industrial Property Rights Holder
  学校法人順天堂
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-132309
- Filing Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-23300128
[Presentation] SphK2/S1PシグナルによるApoE発現制御機構の解析2022
- Author(s)
  駒井真人，野田祐佳，上原孝，高杉展正
- Organizer
  第95回日本生化学会年会
- Data Source
  KAKENHI-PROJECT-20K07014
[Presentation] The analysis for APP-βCTF mediated traffic impairment in AD2021
- Author(s)
  Nanaka Kaneshiro, Tadafumi Hashimoto, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07014
[Presentation] The analysis for APP-βCTF mediated traffic impairment in AD2020
- Author(s)
  Nanaka Kaneshiro, Tadafumi Hashimoto, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-20K07014
[Presentation] アルツハイマー病特異的小胞輸送障害の解明2019
- Author(s)
  金城那香, 櫻井　隆, 上原　孝, 高杉　展正
- Organizer
  第93回　日本生化学会年会
- Data Source
  KAKENHI-PROJECT-17K08272
[Presentation] he analysis for APP-βCTF mediated traffic impairment.2019
- Author(s)
  Kaneshiro N, Sakurai T, Uehara T, Takasugi N.
- Organizer
  Neuroscience 2019 （USA Chicago)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08272
[Presentation] SphK2/S1PシグナリングによるApolipoproteinEのエピジェネティクス制御2019
- Author(s)
  駒井　真人, 上原　孝,　高杉　展正
- Organizer
  第93回　日本生化学会年会
- Data Source
  KAKENHI-PROJECT-17K08272
[Presentation] SphK2/S1PシグナリングによるApolipoproteinEのエピジェネティクス制御2019
- Author(s)
  駒井　真人, 上原　孝,　高杉　展正
- Organizer
  第58回　日本薬学会　中四国支部大会
- Data Source
  KAKENHI-PROJECT-17K08272
[Presentation] Epigenetic regulation of apolipoprotein E by sphingosine-1-phosphate signaling2019
- Author(s)
  Takasugi N, Komai M, Noda Y, Uehara T.
- Organizer
  Neuroscience 2019 （USA Chicago)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08272
[Presentation] アルツハイマー病特異的小胞輸送障害の解明2018
- Author(s)
  金城那香, 櫻井　隆, 上原　孝, 高杉　展正
- Organizer
  第134回　日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K08272
[Presentation] アルツハイマー病特異的小胞輸送障害の解明2018
- Author(s)
  金城那香, 櫻井　隆, 上原　孝, 高杉　展正
- Organizer
  第37回　日本認知症学会
- Data Source
  KAKENHI-PROJECT-17K08272
[Presentation] SphK2/SP シグナルに基づいたアルツハイマー病発症機構の解析2017
- Author(s)
  高杉　展正
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08272
[Presentation] APP-βCTF に特異的に結合するエンドソームタンパク質の解析2016
- Author(s)
  高杉　展正
- Organizer
  日本薬学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26430059
[Presentation] SphK2/S1P シグナルによるアルツハイマー病治療法の開発2016
- Author(s)
  野田　祐佳、高杉　展正
- Organizer
  第129回日本薬理学会近畿部会
- Place of Presentation
  広島県医師会館
- Data Source
  KAKENHI-PROJECT-26430059
[Presentation] The analysis of endosomal proteins, which specifically interact with APP-βCTF2015
- Author(s)
  高杉　展正
- Organizer
  第128回日本薬理学会近畿部会
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-26430059
[Presentation] APP-βCTFに特異的に結合するエンドソームタンパク質の解析2015
- Author(s)
  高杉　展正、　新家　瑠奈、　櫻井　隆
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-26430059
[Presentation] The analysis of endosomal proteins, which specifically interact with APP-βCTF2015
- Author(s)
  高杉　展正
- Organizer
  Neuroscience 2015
- Place of Presentation
  McCormick Place in Chicago
- Year and Date
  2015-10-18
- Data Source
  KAKENHI-PROJECT-26430059
[Presentation] APP-βCTFに特異的に結合するエンドソームタンパク質の解析2015
- Author(s)
  高杉展正、新家瑠奈、櫻井隆
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-23300128
[Presentation] スフィンゴシンキナーゼ/スフィンゴシン―1 リン酸シグナリングによる神経特異的なβセクレターゼ活性制御機構の解析2009
- Author(s)
  高杉展正
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2009-11-15
- Data Source
  KAKENHI-PROJECT-21790061
[Presentation] Identification and analysis of a substrate-specific genetic modulator for γ-secretase activity.2008
- Author(s)
  一色隼人, 高杉展正, 富田泰輔, 岩坪威
- Organizer
  第3回Notch 研究会〜若手の会〜
- Place of Presentation
  三島
- Data Source
  KAKENHI-PROJECT-19790049
[Presentation] Identification and analysis of a substrate-specific genetic modulator for γ-secretase activity.2008
- Author(s)
  一色隼人, 高杉展正, 鈴木邦道, 富田泰輔, 岩坪威
- Organizer
  The 15th Takeda Science Foundation Symposium on Bioscience
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790049
[Presentation] Identification and analysis of a substrate-specific genetic modulator for γ-secretase activity.2008
- Author(s)
  一色隼人, 高杉展正, 鈴木邦道, 富田泰輔, 岩坪威
- Organizer
  SFN 38th Annual Meeting
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-19790049
[Presentation] ゲノムワイドRNAi スクリーニングによるγセクレターゼ活性制御因子の同定2007
- Author(s)
  一色隼人, 高杉展正, 富田泰輔, 岩坪威
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19790049
[Presentation] ゲノムワイドRNAiスクリーニングによるγセクレターゼ活性制御因子の同定2007
- Author(s)
  一色隼人、高杉展正, ら
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19790049
[Presentation] APP-βCTFに特異的に結合するエンドソーム蛋白質の解析
- Author(s)
  高杉展正、新家瑠奈、上窪裕二、櫻井隆
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23300128

1. KASHIYAMA Taku (90338343)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. KAMIKUBO Yuji (80509670)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. TOMITA Taisuke (30292957)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. 橋本唯史 (30334337)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. SAKURAI Takashi (70225845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NUKINA Nobuyuki (10134595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MURAYAMA Takashi (10230012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ARAYA Runa (10391848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 岩坪威

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. 松野建治

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 三谷昌平

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 伊藤弦太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 伊藤昭博

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 熊谷嘉人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 上原孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
16. 桜井正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

TAKASUGI NOBUMASA 高杉 展正

TAKASUGI Nobumasa 高杉 展正

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Co-Researchers

Challenge to develop a multifunctional treatment for Alzheimer's disease based on the amyloid and traffic jam hypotheses.Principal Investigator

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変性神経突起における輸送障害とアルツハイマー病初期病態進展機序の解明

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Establishing quantitative and comprehensive methods for analyzing vesicular traffic impairment to identify the drug candidates for Alzheimer's diseasePrincipal Investigator

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GPCR-Amyloid precursor protein supercomplex regulate neural function

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APP-BACE1結合仲介分子によるアミロイドβ産生制御機構の解明

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Lipid flippase is the novel therapeutic target for the Alzheimer disease, which correlate with endocytic traffic impairment.Principal Investigator

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Simultaneous control of the production and degradation of Amyloid be-ta by Sphingosine kinase/sphingosine-1-phosphate signalingPrincipal Investigator

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Microdomain-dependent acceleration mechanisms for amyloidogenic processing of amyloid precursor protein induced by endocytic membrane traffic impairment

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SPHK/S1Pシグナリングによるβセクレターゼ制御機構の解析Principal Investigator

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Substrate specific modulation of the ....secretase activity by vesicular traffickingPrincipal Investigator

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[Journal Article] Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes2024

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[Journal Article] The Pursuit of the “Inside” of the Amyloid Hypothesis?Is C99 a Promising Therapeutic Target for Alzheimer’s Disease?2023

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[Journal Article] Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage2023

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TAKASUGI NOBUMASA 高杉展正

TAKASUGI Nobumasa 高杉展正