YAMAUCHI Motohiro 山内基弘

Researcher Number	60437910
Other IDs
External Links
Affiliation (Current)	2025: 九州大学, アイソトープ統合安全管理センター(馬出地区), 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 九州大学, アイソトープ統合安全管理センター(馬出地区), 准教授 2014 – 2020: 長崎大学, 原爆後障害医療研究所, 助教 2017: 長崎大学, 学内共同利用施設等, 助教 2013: 長崎大学, 先導生命科学研究支援センター, 助教 2012: 一般財団法人電力中央研究所, 原子力技術研究所, 特別契約研究員 2011: 長崎大学, 大学院・医歯薬学総合研究科, 助教 2009 – 2010: Nagasaki University, 医歯薬学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 63020:Radiation influence-related / Risk sciences of radiation/Chemicals / Risk sciences of radiation and chemicals Except Principal Investigator Basic Section 63020:Radiation influence-related / Medium-sized Section 50:Oncology and related fields / Radiation science / Risk sciences of radiation and chemicals / Science education
Keywords	Principal Investigator DNA二本鎖切断 / DNA修復 / 放射線 / DNA-PKcs / フォーカス / 染色体転座 / ATM / 相分離 / 染色体再編成 / ペアリング … More / 修復 / DNA double-strand break / ヘテロクロマチン / ユークロマチン / Chromosome rearrangement / CRISPR/Cas9 / 癌 / 融合遺伝子 / DNA-PK / 近接 / 53BP1 / Ku80 / 会合 / FISH / H2AX / DNA二重鎖切断 / 細胞周期チェックポイント / γ-H2AX / 応答 … More Except Principal Investigator 染色体転座 / 放射線 / 重粒子線 / DNA二本鎖切断 / DNA修復 / 転写 / DSB修復 / クロマチン / HR / NHEJ / 転写共役型DNA修復 / 発がん / DNA切断 / 3Dライブイメージング / ゲノム不安定性 / 医学放射線生物学 / 染色体異常 / ライブイメージング / ゲノム不安定化 / 53BP1 / 教育・コミュニケーション技術 / 科学と社会・文化 / 分子イメージング / 科学教育 / フィールドセミナー / 放射線健康リスク / 環境放射能解析 / 放射線影響解析 / 科学文化 / フィールドモニタリング / 放射線コミュニケーション / 放射線ラーニング / 原子力防災 / 被ばく線量評価 / 環境放射能 / 放射線影響 / 放射線教育 Less

Does phase-separation of DNA double-strand break repair factors promote chromosome rearrangement?Principal Investigator
- Principal Investigator
  
  山内基弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Kyushu University
全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究
- Principal Investigator
  
  柴田淳史
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Keio University
  Gunma University
Elucidation of transcription-coupled chromosomal translocation pathways between gene loci
- Principal Investigator
  
  Shibata Atsushi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Gunma University
Molecular network that regulates pairing between DNA double-strand breaksPrincipal Investigator
- Principal Investigator
  
  YAMAUCHI Motohiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Nagasaki University
Creation of Radiation Science Culture with High Robustness - A New Horizon of Radiation Learning
- Principal Investigator
  
  MATSUDA Naoki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Science education
- Research Institution
  Nagasaki University
Elucidation of the mechanism of cancer-related gene fusion using CRISPR/Cas9Principal Investigator
- Principal Investigator
  
  YAMAUCHI Motohiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Nagasaki University
Proof of mutual interference between two DNA double strand break sites leading to chromosomal translocation
- Principal Investigator
  
  Niimi Atsuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Gunma University
Analysis of individual fate determination of irradiated cells by using live cell imaging technique
- Principal Investigator
  
  Niimi Atsuko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Gunma University
Elucidation of the molecular mechanism of chromosome translocation formation/suppression after exposure to ionizing radiationPrincipal Investigator
- Principal Investigator
  
  YAMAUCHI Motohiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagasaki University
  Central Research Institute of Electric Power Industry
Demonstration of persistent activation of ATM on translocated chromosomes by Foci on FISH method.Principal Investigator
- Principal Investigator
  
  YAMAUCHI Motohiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagasaki University

[Book] 放射線と安全につきあう - 利用の基礎と実際2017
- Author(s)
  西澤邦秀 , 伊藤茂樹, 松田尚樹, 山内基弘, 柴田理尋, 熊谷純, 山澤弘実, 森泉純, 小山修司, 瓜谷章, 加藤克, 竹中千里, 本間道夫, 小島康明
- Total Pages
  238
- Publisher
  名古屋大学出版会
- ISBN
  9784815808754
- Data Source
  KAKENHI-PROJECT-16H03062
[Journal Article] Inhibition of intracellular ATP synthesis impairs the recruitment of homologous recombination factors after ionizing radiation2024
- Author(s)
  Hayashi Ryota、Okumura Hikaru、Isono Mayu、Yamauchi Motohiro、Unami Daiki、Lusi Rahmartani Tania、Yamamoto Masamichi、Kato Yu、Uchihara Yuki、Shibata Atsushi
- Journal Title
  
  Journal of Radiation Research
  
  Volume: － Issue: 3 Pages: 263-271
- DOI
  10.1093/jrr/rrae005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18232, KAKENHI-PROJECT-21K17888, KAKENHI-PUBLICLY-23H04247, KAKENHI-PROJECT-23K21749
[Journal Article] Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks2023
- Author(s)
  Motohiro Yamauchi, Reona Kato, Takaaki Yasuhara, Yuki Uchihara, Miyako Hirakawa, Kie Ozaki, Yu Abe, Hiroki Shibata, Reika Kawabata-Iwakawa, Aizhan Shakayeva, Palina Kot, Kiyoshi Miyagawa, Keiji Suzuki, Atsushi Shibata, Naoki Matsuda
- Journal Title
  
  BioRxiv
  
  Volume: -
- DOI
  10.1101/2023.09.07.556638
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12376
[Journal Article] DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production2022
- Author(s)
  Uchihara Yuki、Permata Tiara Bunga Mayang、Sato Hiro、Kawabata-Iwakawa Reika、Katada Sayako、Gu Wenchao、Kakoti Sangeeta、Yamauchi Motohiro、Kato Reona、Gondhowiardjo Soehartati、Hosen Naoki、Yasuhara Takaaki、Shibata Atsushi
- Journal Title
  
  Molecular Cell
  
  Volume: 82 Issue: 14 Pages: 2557-2570.e7
- DOI
  10.1016/j.molcel.2022.04.030
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17888, KAKENHI-PUBLICLY-21H05504, KAKENHI-PROJECT-20K06875, KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-23K21749
[Journal Article] RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair2022
- Author(s)
  Yasuhara Takaaki、Kato Reona、Yamauchi Motohiro、Uchihara Yuki、Zou Lee、Miyagawa Kiyoshi、Shibata Atsushi
- Journal Title
  
  Cell Reports
  
  Volume: 38 Issue: 5 Pages: 110335-110335
- DOI
  10.1016/j.celrep.2022.110335
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04713, KAKENHI-PUBLICLY-20H04879, KAKENHI-PROJECT-20J12698, KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-21K17888, KAKENHI-PROJECT-20KK0339, KAKENHI-PUBLICLY-21H05504, KAKENHI-PROJECT-23K21749, KAKENHI-PROJECT-23K21750
[Journal Article] Mechanism of chromosome rearrangement arising from single-strand breaks2021
- Author(s)
  Kot Palina、Yasuhara Takaaki、Shibata Atsushi、Hirakawa Miyako、Abe Yu、Yamauchi Motohiro、Matsuda Naoki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 572 Pages: 191-196
- DOI
  10.1016/j.bbrc.2021.08.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04713, KAKENHI-PUBLICLY-20H04879, KAKENHI-PROJECT-21H00920, KAKENHI-PROJECT-20K21536, KAKENHI-PUBLICLY-21H05504, KAKENHI-PROJECT-23K21749, KAKENHI-PROJECT-23K21750
[Journal Article] High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells2021
- Author(s)
  Permata Tiara Bunga Mayang、Sato Hiro、Gu Wenchao、Kakoti Sangeeta、Uchihara Yuki、Yoshimatsu Yukihiko、Sato Itaru、Kato Reona、Yamauchi Motohiro、Suzuki Keiji、Oike Takahiro、Tsushima Yoshito、Gondhowiardjo Soehartati、Ohno Tatsuya、Yasuhara Takaaki、Shibata Atsushi
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 62 Issue: 5 Pages: 773-781
- DOI
  10.1093/jrr/rrab050
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08195, KAKENHI-PROJECT-17H04713, KAKENHI-PUBLICLY-20H04879, KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-21K17888, KAKENHI-PUBLICLY-21H05504, KAKENHI-PROJECT-23K21749, KAKENHI-PROJECT-23K21750
[Journal Article] RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells2020
- Author(s)
  Nakajima Nakako Izumi、Yamauchi Motohiro、Kakoti Sangeeta、Cuihua Liu、Kato Reona、Permata Tiara Bunga Mayang、Iijima Moito、Yajima Hirohiko、Yasuhara Takaaki、Yamada Shigeru、Hasegawa Sumitaka、Shibata Atsushi
- Journal Title
  
  DNA Repair
  
  Volume: 91-92 Pages: 102872-102872
- DOI
  10.1016/j.dnarep.2020.102872
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-17H04713, KAKENHI-PUBLICLY-20H04879, KAKENHI-PROJECT-18K11645, KAKENHI-PROJECT-18K18191
[Journal Article] High background area for radiation education2019
- Author(s)
  Matsuda N, Fukuda N, Yamauchi M, Tsunoyama Y, Tomita S, Kita M
- Journal Title
  
  Radiation Protection Dosimetry
  
  Volume: 印刷中 Issue: 3-4 Pages: 294-297
- DOI
  10.1093/rpd/ncz084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03062
[Journal Article] Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP12017
- Author(s)
  Motohiro Yamauchi, Atsushi Shibata, Keiji Suzuki, Masatoshi Suzuki, Atsuko Niimi, Hisayoshi Kondo, Miwa Miura, Miyako Hirakawa, Keiko Tsujita, Shunichi Yamashita, Naoki Matsuda
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 41812-41812
- DOI
  10.1038/srep41812
- NAID
  120006987560
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02816, KAKENHI-PROJECT-26281023, KAKENHI-PROJECT-26701005, KAKENHI-PROJECT-26670549, KAKENHI-PROJECT-15K00542, KAKENHI-PROJECT-15K15447, KAKENHI-PROJECT-16H03062
[Journal Article] 3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation2017
- Author(s)
  Hagiwara Yoshihiko、Niimi Atsuko、Isono Mayu、Yamauchi Motohiro、Yasuhara Takaaki、Limsirichaikul Siripan、Oike Takahiro、Sato Hiro、Held Kathryn D.、Nakano Takashi、Shibata Atsushi
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 65 Pages: 109370-109381
- DOI
  10.18632/oncotarget.22679
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26701005, KAKENHI-PROJECT-15H02816, KAKENHI-PROJECT-15K15447, KAKENHI-PROJECT-17H04713
[Journal Article] Identification of DNA double strand breaks at chromosome boundaries along the track of particle irradiation2016
- Author(s)
  Atsuko Niimi, Motohiro Yamauchi, Siripan Limsirichaikul, Ryota Sekine, Takahiro Oike, Hiro Sato, Keiji Suzuki, Kathryn D. Held, Takashi Nakano, Atsushi Shibata
- Journal Title
  
  Genes Chromosomes & Cancer
  
  Volume: 55 Issue: 8 Pages: 650-660
- DOI
  10.1002/gcc.22367
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02816, KAKENHI-PROJECT-16H05388, KAKENHI-PROJECT-26701005, KAKENHI-PROJECT-26670549, KAKENHI-PROJECT-15K15447, KAKENHI-PROJECT-16H03062
[Journal Article] Effect of Introducing Small-animal Molecular Imaging into Radioisotope Center2016
- Author(s)
  西弘大、松田尚樹、三浦美和、林田りか、山内基弘、平川美弥子、高尾秀明、工藤崇
- Journal Title
  
  Japanese Journal of Radiation Safety Management
  
  Volume: 15 Issue: 1 Pages: 74-79
- DOI
  10.11269/jjrsm.15.74
- NAID
  130006895868
- ISSN
  1347-1503, 1884-9512
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H03062
[Journal Article] Perception of radiation risk by Japanese radiation specialists evaluated as a safe dose before the Fukushima Nuclear Accident.2016
- Author(s)
  Miura M, Ono K, Yamauchi M, Matsuda N
- Journal Title
  
  Health Phys
  
  Volume: 110 Issue: 6 Pages: 558-562
- DOI
  10.1097/hp.0000000000000486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H03062
[Journal Article] 放射線被ばく後にできる DNA 損傷に対するヒト細胞の防御機構2014
- Author(s)
  山内基弘、三浦美和、松田尚樹
- Journal Title
  
  Japanese Journal of Radiation Safety Management
  
  Volume: 13 Issue: 1 Pages: 79-83
- DOI
  10.11269/jjrsm.13.79
- NAID
  130004941393
- ISSN
  1347-1503, 1884-9512
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24710063, KAKENHI-PROJECT-25282042
[Journal Article] ATM-dependent cellular response to DNA double strand breaks plays a pivotal role in the maintenance of the integrity of the genome2011
- Author(s)
  鈴木啓司、山内基弘、山下俊一
- Journal Title
  
  Radiation Protection Dosimetry
  
  Volume: 143巻 Pages: 279-283
- NAID
  120006985149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710061
[Journal Article] Mode of ATM-dependent suppression of chromosome translocation2011
- Author(s)
  山内基弘、鈴木啓司、岡泰由、鈴木正敏、近藤久義、山下俊一
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 416巻 Pages: 111-118
- NAID
  120006985345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710061
[Journal Article] Creating localized DNA double-strand breaks with microirradiation2011
- Author(s)
  鈴木啓司、山内基弘、岡泰由、鈴木正敏、山下俊一
- Journal Title
  
  Nature Protocols
  
  Volume: 6巻 Pages: 134-139
- NAID
  120006985036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710061
[Journal Article] Persistence and dynamics of DNA damage signal amplification determined by microcolony formation and live-cell imaging2011
- Author(s)
  岡泰由、山内基弘、鈴木正敏、山下俊一、鈴木啓司
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 52巻 Pages: 766-774
- NAID
  10029653065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710061
[Journal Article] Requirement of ATM-dependent pathway for the repair of a subset of DNA double strand breaks created by restriction endonucleases2010
- Author(s)
  鈴木啓司、高橋麻衣子、岡泰由、山内基弘、鈴木正敏、山下俊一
- Journal Title
  
  Genome Integrity
  
  Volume: 1巻 Pages: 4-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710061
[Journal Article] Image-based quantitative determination of DNA damage signal reveals a threshold for G2 checkpoint activation in response to ionizing radiation.2010
- Author(s)
  石川彩、山内基弘、鈴木啓司、山下俊一
- Journal Title
  
  Genome Integrity
  
  Volume: 1巻 Pages: 10-10
- NAID
  120006985122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710061
[Journal Article] Image-based quantitative determination of DNA damage signal reveals a threshold for G2 checkpoint activation in response to ionizing radiation2010
- Author(s)
  石川彩、山内基弘、鈴木啓司、山下俊一
- Journal Title
  
  Genome Integrity
  
  Volume: 1巻 Pages: 10-10
- NAID
  120006985122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710061
[Journal Article] A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks2010
- Author(s)
  鈴木啓司、山内基弘、岡泰由、鈴木正敏、山下俊一
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 38巻
- NAID
  120006984199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710061
[Journal Article] Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells, cell growth suppression by p53 expression and the suppression mechanism.2009
- Author(s)
  Hori M, Suzuki K, Udono MU, Yamauchi M, Mine M, Watanabe M, Kondo S, Hozumi Y.
- Journal Title
  
  Archives of Dermatological Research 301
  
  Pages: 631-646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710061
[Journal Article] Biological significance of DNA damage checkpoint and the mode of checkpoint signal amplification.2009
- Author(s)
  Yamauchi M, Suzuki K, Yamashita S.
- Journal Title
  
  Acta Medica Nagasakiensia 53(Suppl.)
  
  Pages: 3-5
- NAID
  110007050116
- Data Source
  KAKENHI-PROJECT-21710061
[Presentation] 放射線誘発DNA二本鎖切断の相同組換え修復における、BRCA1とスプライシング因子SART1のエピスタティックな関係2023
- Author(s)
  山内基弘、尾﨑貴恵、内原脩貴、安原崇哲、柴田淳史
- Organizer
  日本放射線影響学会第66回大会
- Data Source
  KAKENHI-PROJECT-22K12376
[Presentation] BRCA1とスプライシング因子SART1は協調してDNA二本鎖切断のリセクションを促進している2023
- Author(s)
  尾﨑貴恵、内原脩貴、阿部悠、安原崇哲、柴田淳史、山内基弘
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K12376
[Presentation] BRCA1依存的なDNA二本鎖切断の相同組換え修復におけるスプライシング因子SART1の関与2023
- Author(s)
  山内基弘、尾﨑貴恵、内原脩貴、安原崇哲、柴田淳史
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K12376
[Presentation] 放射線被ばくで生じたDNA損傷を正確に修復する分子メカニズム2020
- Author(s)
  山内基弘、平川美弥子、松田尚樹
- Organizer
  日本放射線安全管理学会
- Data Source
  KAKENHI-PROJECT-18K11645
[Presentation] DNA二本鎖切断の相同組換え修復におけるスプライシング因子SART1とBRCA1の協調的働き2019
- Author(s)
  山内基弘、柴田淳史、安原崇哲、加藤玲於奈、平川美弥子、Moe Moe Han、宮川清、鈴木啓司、松田尚樹
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11645
[Presentation] スプライシング因子SART1がDNA二本鎖切断の相同組換え修復を促進するメカニズム2019
- Author(s)
  山内基弘、柴田淳史、加藤玲於奈、安原崇哲、平川美弥子、ハンムームー、宮川清、鈴木啓司、松田尚樹
- Organizer
  日本放射線影響学会第62回大会
- Data Source
  KAKENHI-PROJECT-18K11645
[Presentation] DNA二本鎖切断の相同組換え修復におけるBRCA1とスプライシング因子SART1の協調的働き2019
- Author(s)
  山内基弘、柴田淳史、鈴木啓司、宮川清
- Organizer
  第78回日本癌学会学術大会
- Data Source
  KAKENHI-PROJECT-18K11645
[Presentation] Pre-mRNA splicing factor SART1 facilitates homologous recombination repair by recruiting BRCA1 to DNA double-strand breaks.2019
- Author(s)
  Motohiro Yamauchi, Atsushi Shibata, Takaaki Yasuhara, Yoshihiko Hagiwara, Miyako Hirakawa, Aizhan Shakayeva, Moe Moe Han, Keiji Suzuki, Naoki Matsuda.
- Organizer
  The 3rd International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11645
[Presentation] 放射線健康リスク科学教育における生命研究サンプルの利用2018
- Author(s)
  山内基弘, 西弘大, 三浦美和, 福田直子, 工藤崇, 松田尚樹
- Organizer
  日本放射線安全管理学会第17回学術大会
- Data Source
  KAKENHI-PROJECT-16H03062
[Presentation] The role of splicing factor SART1 in DNA double-strand break repair by homologous recombination.2018
- Author(s)
  Aizhan Shakayeva, Motohiro Yamauchi, Miyako Hirakawa, Naoki Matsuda
- Organizer
  The 14th International Workshop on Ionizing Radiation Monitoring.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11645
[Presentation] DNA二本鎖切断の相同組換え修復におけるBRCA1とスプライシング因子SART1の関係2018
- Author(s)
  山内基弘、柴田淳史、安原崇哲、萩原慶彦、平川美弥子、ハンムームー、鈴木啓司、松田尚樹
- Organizer
  日本放射線影響学会第61回大会
- Data Source
  KAKENHI-PROJECT-18K11645
[Presentation] The role of splicing factor SART1 in DNA double-strand break repair by homologous recombination2018
- Author(s)
  Shakayeva A, Yamauchi M, Hirakawa M, Matsuda N
- Organizer
  The 14th International Workshop on Ionizing Radiation Monitoring
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03062
[Presentation] High background area for radiation education2018
- Author(s)
  Matsuda N, Fukuda N, Yamauchi M, Kita M
- Organizer
  9th International Conference on High Level Environmental Radiation Areas
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03062
[Presentation] Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP12017
- Author(s)
  Yamauchi M, Shibata A, Suzuki K, Suzuki M, Niimi A, Kondo H, Miura M, Hirakawa M, Tsujita K, Yamashita S, Matsuda N
- Organizer
  Ataxia Telangiectasia Workshop 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03062
[Presentation] A role of pre-mRNA splicing factor SART1 in DNA double-strand break repair by homologous recombination2017
- Author(s)
  山内基弘,副島悠生,平川美弥子,辻田啓子,ムームーハン,柿田聖太,柴田淳史,安原崇哲,鈴木啓司,松田尚樹
- Organizer
  日本放射線影響学会第60回大会
- Data Source
  KAKENHI-PROJECT-16H03062
[Presentation] Role of pre-mRNA splicing factors in homologous recombination of DNA double-strand breaks2017
- Author(s)
  Han MM, Yamauchi M, Matsuda N
- Organizer
  The 13th International Workshop on Ionizing Radiation Monitoring
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H03062
[Presentation] Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1.2017
- Author(s)
  山内基弘、柴田淳史、鈴木啓司、鈴木正敏、新美敦子、近藤久義、三浦美和、平川美弥子、辻田啓子、山下俊一、松田尚樹
- Organizer
  Ataxia Telangiectasia Workshop 2017
- Place of Presentation
  ミラノ（イタリア）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00542
[Presentation] 重粒子線照射により誘発される特異なDNA損傷形状の可視化2016
- Author(s)
  新美敦子, 山内基弘, シリパンリムシリチャイクル, 関根崚太, 磯野真由, 尾池貴洋, 佐藤浩央, 鈴木啓司, 中野隆史, 柴田淳史
- Organizer
  第39回　日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K15447
[Presentation] 看護師を対象とした放射線教育プログラムの新展開2016
- Author(s)
  西弘大, 松田尚樹, 山内基弘, 折田真紀子, 高村昇, 工藤崇
- Organizer
  日本放射線安全管理学会第15回学術大会
- Data Source
  KAKENHI-PROJECT-16H03062
[Presentation] 重粒子線照射により誘発される特異なDNA損傷形状の可視化2016
- Author(s)
  新美敦子, 山内基弘, シリパンリムシリチャイクル, 関根崚太, 磯野真由, 尾池貴洋, 佐藤浩央, 鈴木啓司, 中野隆史1, 柴田淳史
- Organizer
  第39回　日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H02816
[Presentation] CRISPR/Cas9を用いた癌関連融合遺伝子の生成頻度の定量アッセイの樹立2016
- Author(s)
  山内基弘
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-15K00542
[Presentation] Establishment of a novel quantitative assay for cancer-related gene fusion using CRISPR/Cas92016
- Author(s)
  山内基弘、平川美弥子、辻田啓子、松田尚樹
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Data Source
  KAKENHI-PROJECT-15K00542
[Presentation] CRISPR/Cas9を用いた癌関連融合遺伝子の生成頻度の定量アッセイの樹立2016
- Author(s)
  山内基弘
- Organizer
  第75回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H03062
[Presentation] Analysis of cluster DNA double strand break formation using high-resolution microscopy2016
- Author(s)
  Atsuko Niimi, Nakajima Izumi Nakako, Motohiro Yamauchi, Siripan Limsirichaikul, Takahiro Oike, Hiro Sato, Penny A. Jeggo, Kathryn D. Held, Takashi Nakano, Atsushi Shibata
- Organizer
  10th Quinquennial Conference on Responses to DNA Damage
- Place of Presentation
  Egmond aan Zee (The Netherlands)
- Year and Date
  2016-04-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15447
[Presentation] Analysis of cluster DNA double strand break formation using high-resolution microscopy2016
- Author(s)
  Atsuko Niimi, Nakajima Izumi Nakako, Motohiro Yamauchi, Siripan Limsirichaikul, Takahiro Oike, Hiro Sato, Penny A. Jeggo, Kathryn D. Held, Takashi Nakano, Atsushi Shibata
- Organizer
  10th Quinquennial Conference on Responses to DNA Damage
- Place of Presentation
  Egmond aan Zee (The Netherlands)
- Year and Date
  2016-04-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02816
[Presentation] ATMとDNA-PKcsによるDNA二本鎖切断同士の会合の抑制2015
- Author(s)
  山内基弘、柴田淳史、鈴木啓司
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K00542
[Presentation] 高LET重粒子線照射により誘発される２つの異なる染色体間にまたがるクラスターDNA損傷の同定2015
- Author(s)
  新美敦子, 山内基弘, シリパンリムシリチャイクル, 関根崚太, 磯野真由, 尾池貴洋, 佐藤浩央, 鈴木啓司, 中野隆史, 柴田淳史
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド(神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H02816
[Presentation] ATM and DNA-PKcs suppress pairing between multiple DNA double-strand breaks2015
- Author(s)
  山内基弘、鈴木啓司、柴田淳史、新美敦子、鈴木正敏、近藤久義、三浦美和、平川美弥子、山下俊一、松田尚樹
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-15K00542
[Presentation] Factors affecting interaction between multiple DNA double-strand breaks2015
- Author(s)
  山内基弘、鈴木啓司、柴田淳史、鈴木正敏、近藤久義、三浦美和、平川美弥子、山下俊一、松田尚樹
- Organizer
  15th International Congress of Radiation Research
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-05-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00542
[Presentation] 高LET重粒子線照射により誘発される２つの異なる染色体間にまたがるクラスターDNA損傷の同定2015
- Author(s)
  新美敦子, 山内基弘, シリパンリムシリチャイクル, 関根崚太, 磯野真由, 尾池貴洋, 佐藤浩央, 鈴木啓司, 中野隆史, 柴田淳史
- Organizer
  第38回日本分子生物学会年会　第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド(神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K15447
[Presentation] DNA二本鎖切断同士の会合に影響を与える因子2014
- Author(s)
  山内基弘、鈴木啓司、柴田淳史、近藤久義、三浦美和、平川美弥子、山下俊一、松田尚樹
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-24710063
[Presentation] DNA二本鎖切断同士の近接および染色体転座頻度に影響を与える因子2014
- Author(s)
  山内基弘、鈴木啓司、柴田淳史、近藤久義、三浦美和、平川美弥子、山下俊一、松田尚樹
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  かごしま県民交流センター、鹿児島県鹿児島市
- Year and Date
  2014-10-03
- Data Source
  KAKENHI-PROJECT-24710063
[Presentation] DNA二本鎖切断間の会合および染色体転座頻度に影響を与える因子2014
- Author(s)
  山内基弘、柴田淳史、鈴木啓司
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜、神奈川県横浜市
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-24710063
[Presentation] ATMによる染色体転座抑制機構2013
- Author(s)
  山内基弘、鈴木啓司
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜市　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24710063
[Presentation] 染色体転座形成におけるp53 binding protein 1 (53BP1) の関与2013
- Author(s)
  山内基弘、鈴木啓司、近藤久義、三浦美和、山下俊一、松田尚樹
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市　神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-24710063
[Presentation] Involvement of 53BP1 in a DNA double-strand break repair pathway that generates chromosome translocation.2012
- Author(s)
  山内基弘
- Organizer
  日本放射線影響学会第55回大会
- Place of Presentation
  東北大学川内北キャンパス（宮城県）
- Data Source
  KAKENHI-PROJECT-24710063
[Presentation] 誤ったDNA二重鎖切断再結合部位に対するATM依存的チェックポイント応答2010
- Author(s)
  山内基弘
- Organizer
  日本放射線影響学会第53回大会、シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21710061
[Presentation] 誤ったDNA二重鎖切断再結合部位に対するATM依存的チェックポイント応答2010
- Author(s)
  山内基弘
- Organizer
  日本放射線影響学会第53回大会
- Place of Presentation
  京都
- Year and Date
  2010-10-20
- Data Source
  KAKENHI-PROJECT-21710061
[Presentation] ATMによる染色体転座の認識2009
- Author(s)
  山内基弘、鈴木啓司、山下俊一
- Organizer
  日本放射線影響学会第52回大会,ワークショップ
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21710061
[Presentation] ATMによる染色体転座の認識2009
- Author(s)
  山内基弘、鈴木啓司、山下俊一
- Organizer
  日本放射線影響学会第52回大会
- Place of Presentation
  広島
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-21710061
[Presentation] ATM-p53 axis suppresses propagation of chromosome translocation by foci-growth-dependent G1 checkpoint2009
- Author(s)
  山内基弘
- Organizer
  Nagasaki Global COE program young investigators' international symposium,シンポジウム
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21710061

1. SHIBATA Atsushi (30707633)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. Niimi Atsuko (50508984)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. 安原崇哲 (90757056)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. MATSUDA Naoki (00304973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. 林田直美 (00420638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 西弘大 (10719496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 熊谷敦史 (40448494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 堀口逸子 (50338399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 桧垣正吾 (50444097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 藤本登 (60274510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 北実 (60359875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 三好弘一 (90229906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 角山雄一 (90314260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 早瀬隆司 (40301361)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 尾崎貴恵 (80933548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 宮成悠介 (60469608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 佐藤浩央

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 内原脩貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMAUCHI Motohiro 山内 基弘

Research Projects

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Co-Researchers

Does phase-separation of DNA double-strand break repair factors promote chromosome rearrangement?Principal Investigator

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全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究

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Elucidation of transcription-coupled chromosomal translocation pathways between gene loci

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Molecular network that regulates pairing between DNA double-strand breaksPrincipal Investigator

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Creation of Radiation Science Culture with High Robustness - A New Horizon of Radiation Learning

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Elucidation of the mechanism of cancer-related gene fusion using CRISPR/Cas9Principal Investigator

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Proof of mutual interference between two DNA double strand break sites leading to chromosomal translocation

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Analysis of individual fate determination of irradiated cells by using live cell imaging technique

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Elucidation of the molecular mechanism of chromosome translocation formation/suppression after exposure to ionizing radiationPrincipal Investigator

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Demonstration of persistent activation of ATM on translocated chromosomes by Foci on FISH method.Principal Investigator

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[Book] 放射線と安全につきあう - 利用の基礎と実際2017

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[Journal Article] Inhibition of intracellular ATP synthesis impairs the recruitment of homologous recombination factors after ionizing radiation2024

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[Journal Article] Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks2023

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YAMAUCHI Motohiro 山内基弘

[Journal Article] 3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation2017