Koyama Nobuhiro 小山信裕

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KOYAMA Nobuhiro 小山信裕

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Researcher Number	60439156
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2021: 北里大学, 薬学部, 講師 2015: 北里大学, 薬学部, 助教 2011 – 2012: 北里大学, 薬学部, 助教 2007 – 2008: Kitasato University, 薬学部, 助教 2006: 北里大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Chemical pharmacy / Basic Section 38040:Bioorganic chemistry-related / Living organism molecular science Except Principal Investigator Chemical pharmacy / Living organism molecular science / Science and Engineering
Keywords	Principal Investigator ケミカルバイオロジー / MRSA / 感染症 / 標的分子 / 微生物由来化合物 / MAC / 抗酸菌 / 肺 MAC 症 / 肺MAC症 / 真菌症 … More / MAC症 / 結核症 / 抗感染症剤 / ケミカルバイオロジ－ / 結合タンパク質 / 天然物 / メチシリン耐性黄色ブドウ球菌 / 微生物代謝産物 / 機能分子 … More Except Principal Investigator 天然物 / 感染症 / 抗結核剤 / カルピナクタム / 固相合成 / ペプチド / 抗結核薬 / ケミカルバイォロジー / 結合タンパク質 / 標的分子 / ケミカルバイオロジー / 医療福祉 / 循環器・高血圧 / トリグリセリド / 中性脂肪 / コレステロール / 医療・福祉 / 微生物由来機能分子 / 阻害剤 / 脂質代謝 Less

Discovery of anti-mycobacterial drug leads from microbial sourcesPrincipal Investigator
- Principal Investigator
  
  小山信裕
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Kitasato University
Discovery of new anti-infectives based on chemical biologyPrincipal Investigator
- Principal Investigator
  
  Koyama Nobuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
Development of anti-tuberculosis drugs based on calpinactam
- Principal Investigator
  
  NAGAI Kenichiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
DEVELOPMENT OF NEW MICROBIAL AGENT RESTORING MRSA SUSCEPTIBILITYTO ss-LACATAM DRUGSPrincipal Investigator
- Principal Investigator
  
  KOYAMA Nobuhiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kitasato University
THE CHEMICAL BIOLOGY OF NEW MICROBIAL ANTI-INFECTIVE AGENTS
- Principal Investigator
  
  TOMODA Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kitasato University
DISCOVERY OF ANTI-INFECTIVE AGENTS AND THE DEVELOPMENT TO CHEMICAL BIOLOGYPrincipal Investigator
- Principal Investigator
  
  KOYAMA Nobuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kitasato University
脂質代謝を制御する機能分子プローブの創製
- Principal Investigator
  
  TOMODA Hiroshi
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Kitasato University

[Journal Article] Penicillic acid congener, a new inhibitor of BMP-induced alkaline phosphatase activity in myoblasts, produced by the fungus Penicillium sp. BF-03432020
- Author(s)
  Koyama N., Otoguro Y., Ohte S., Katagiri T., Tomoda H.
- Journal Title
  
  Nat. Prod. Communum.
  
  Volume: 15 Issue: 9 Pages: 1-1
- DOI
  10.1177/1934578x20942653
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05464
[Journal Article] Quantitative analysis of selective glycosylation of saccharides with aromatic amines2020
- Author(s)
  Hanai T, Shimada K, Koyama N, Nohara Y.
- Journal Title
  
  Carbohydr. Res.
  
  Volume: 498 Pages: 108171-108171
- DOI
  10.1016/j.carres.2020.108171
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05464
[Journal Article] Evaluation of anti-mycobacterial compounds in a silkworm infection model with Mycobacteroides abscessus2020
- Author(s)
  Hosoda K, Koyama N, Hamamoto H, Yagi A, Uchida R, Kanamoto A, Tomoda H.
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 21 Pages: 4971-4971
- DOI
  10.3390/molecules25214971
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05464, KAKENHI-PROJECT-19J15511
[Journal Article] Steffimycin E, a new anti-mycobacterial agent against Mycobacterium avium complex, produced by Streptomyces sp. OPMA028522020
- Author(s)
  Koyama Nobuhiro、Shigeno Satoru、Kanamoto Akihiko、Tomoda Hiroshi
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: - Issue: 8 Pages: 581-584
- DOI
  10.1038/s41429-020-0290-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05464
[Journal Article] A new diketopiperazine-like inhibitor of bone morphogenetic protein-induced osteoblastic differentiation produced by marine-derived Aspergillus sp. BFM-00852020
- Author(s)
  Ohte S, Shiokawa T, Koyama N, Katagiri T, Imada C, Tomoda H.
- Journal Title
  
  J. Antibiot.
  
  Volume: 73 Issue: 8 Pages: 554-554
- DOI
  10.1038/s41429-020-0316-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05464
[Journal Article] MS network-based screening for new antibiotics discovery2019
- Author(s)
  Koyama N & Tomoda H
- Journal Title
  
  J Antibiot
  
  Volume: 72 Issue: 1 Pages: 54-56
- DOI
  10.1038/s41429-018-0109-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05464, KAKENHI-PROJECT-26253009
[Journal Article] Discovery of Nosiheptide, Griseoviridin, and Etamycin as Potent Anti-Mycobacterial Agents against Mycobacterium avium Complex2019
- Author(s)
  Hosoda K, Koyama N, Kanamoto A, Tomoda H
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 8 Pages: 1495-1495
- DOI
  10.3390/molecules24081495
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05464
[Journal Article] Anti-Rhizopus activity of tanzawaic acids produced by the hot spring-derived fungus Penicillium sp. BF-00052018
- Author(s)
  Tominaga T, Uchida R, Koyama N, Tomoda H
- Journal Title
  
  J Antibiot
  
  Volume: 未定 Issue: 7 Pages: 626-632
- DOI
  10.1038/s41429-018-0049-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07867, KAKENHI-PROJECT-16H05095
[Journal Article] Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides2016
- Author(s)
  Nguyen DD, Melnik AV, Koyama N, Lu X, Schorn M, Fang J, Aguinaldo K, Lincecum TL Jr, Ghequire MG, Carrion VJ, Cheng TL, Duggan BM, Malone JG, Mauchline TH, Sanchez LM, Kilpatrick AM, Raaijmakers JM, Mot R, Moore BS, Medema MH, Dorrestein PC
- Journal Title
  
  Nat Microbiol
  
  Volume: 2 Issue: 1 Pages: 16197-16197
- DOI
  10.1038/nmicrobiol.2016.197
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07867
[Journal Article] Identification and characterization of natural microbial products that alter the free d-aspartate content of mammalian cells2016
- Author(s)
  Katane M, Kaneko Y, Watanabe M, Doi Y, Tanaka T, Kasuga Y, Yoshida N, Kumakubo S, Nakayama K, Matsuda S, Furuchi T, Saitoh Y, Sekine M, Koyama N, Tomoda H, Homma H
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 26 Issue: 2 Pages: 556-560
- DOI
  10.1016/j.bmcl.2015.11.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07867
[Journal Article] Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking2016
- Author(s)
  Wang M,.....Koyama N,.....Bandeira N (total 126 numbers)
- Journal Title
  
  Nat Biotechnol
  
  Volume: 34 Issue: 8 Pages: 828-837
- DOI
  10.1038/nbt.3597
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07867
[Journal Article] Structure-activity analysis of Gram-positive bacterium-producing lasso peptides with anti-mycobacterial activity2016
- Author(s)
  Inokoshi J, Koyama N, Miyake M, Shimizu Y, Tomoda H
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 30375-30375
- DOI
  10.1038/srep30375
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07867
[Journal Article] A metabolomics guided exploration of marine natural product chemical space2016
- Author(s)
  Floros DJ, Jensen PR, Dorrestein PC, Koyama N
- Journal Title
  
  Metabolomics
  
  Volume: 12 Issue: 9 Pages: 145-145
- DOI
  10.1007/s11306-016-1087-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07867
[Journal Article] Discovery of new hazimycin congeners from Kitasatospora sp. P071012015
- Author(s)
  Koyama N, Sato H, Tomoda H
- Journal Title
  
  Acta Pham Sin B
  
  Volume: 5 Issue: 6 Pages: 564-568
- DOI
  10.1016/j.apsb.2015.07.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07867
[Journal Article] Discovery of nosokophic acid, a predicted intermediate of moenomycins, from nosokomycin-producing Streptomyces sp. K04-0144.2013
- Author(s)
  Koyama N, Tokura Y, Takahashi Y, Tomoda H.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 23 Issue: 3 Pages: 860-863
- DOI
  10.1016/j.bmcl.2012.11.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790020
[Journal Article] Anti-infectious agents against MRSA.2012
- Author(s)
  Koyama N, Inokoshi J, Tomoda H.
- Journal Title
  
  Molecules
  
  Volume: 18 Issue: 1 Pages: 204-224
- DOI
  10.3390/molecules18010204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790020
[Journal Article] New structural scaffold 14-membered macrocyclic lactone ring for selective inhibitors of cell wall peptidoglycan biosynthesis in Staphylococcus aureus2012
- Author(s)
  Koyama N, Yotsumoto M, Onaka H, Tomoda H
- Journal Title
  
  J Antibiot
  
  Volume: 66 Issue: 5 Pages: 303-304
- DOI
  10.1038/ja.2012.122
- NAID
  10031176583
- Data Source
  KAKENHI-PROJECT-23790020
[Journal Article] Synthesis and antimycobacterial activity of calpinactam derivatives2012
- Author(s)
  Kenichiro Nagai, Nobuhiro Koyama, Noriko Sato, Chisato Yanagisawa, Hiroshi Tomoda
- Journal Title
  
  Bioorg.Med.Chem.Lett
  
  Volume: 22 Pages: 7739-7741
- URL
  http://dx.doi.org/10.1016/j.bmcl.2012.09.069
- Data Source
  KAKENHI-PROJECT-23790019
[Journal Article] The nonantibiotic small molecule cyslabdan enhances the potency of β-lactams against MRSA by inhibiting pentaglycine interpeptide bridge synthesis.2012
- Author(s)
  Koyama N, Tokura Y, Münch D, Sahl HG, Schneider T, Shibagaki Y, Ikeda H, Tomoda H.
- Journal Title
  
  PLoS One.
  
  Volume: 7 Issue: 11 Pages: e48981-e48981
- DOI
  10.1371/journal.pone.0048981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790020, KAKENHI-PLANNED-22108006
[Journal Article] Synthesis and antimycobacterial activity of calpinactam derivatives2012
- Author(s)
  Kenichiro Nagai
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 22 Issue: 24 Pages: 7739-7741
- DOI
  10.1016/j.bmcl.2012.09.069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790019, KAKENHI-PROJECT-23790020
[Journal Article] Search Method for Inhibitors of Staphyloxanthin Production by Methicillin-Resistant Staphylococcus aureus2012
- Author(s)
  Sakai K, et al
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 35 Issue: 1 Pages: 48-53
- DOI
  10.1248/bpb.35.48
- NAID
  130001872341
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310146, KAKENHI-PROJECT-23790020
[Journal Article] New cyslabdans B and C, potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus produced by Streptomyces sp.K04-01442011
- Author(s)
  Koyama N, et al
- Journal Title
  
  Acta Pharmceutica Sinica B
  
  Volume: 1 Issue: 4 Pages: 236-239
- DOI
  10.1016/j.apsb.2011.10.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310146, KAKENHI-PROJECT-23790020
[Journal Article] Structure and total synthesis of fungal calpinactam, a new antimycobacterial agent2010
- Author(s)
  Koyama N, et al
- Journal Title
  
  Org Lett 12
  
  Pages: 432-435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310146
[Journal Article] Calpinactam, A New Anti-mycobacterial Agent, Produced by Mortierella alpina FKI-49052010
- Author(s)
  Koyama N, et al
- Journal Title
  
  J Antibiot (in press)
  
  Pages: 183-186
- NAID
  10030708126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21310146
[Journal Article] Inhibition of lipid droplet accumulation in mouse macrophages by stemphone deri vatives2008
- Author(s)
  Koyama N
- Journal Title
  
  J Antibiot 61
  
  Pages: 509-514
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19710191
[Journal Article] Relative and absolute stereochemistry of quinadoline B, an inhibitor of lipid dror let synthesis in macrophages2008
- Author(s)
  Koyama N
- Journal Title
  
  Org Lett 10
  
  Pages: 5273-5276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19710191
[Journal Article] Structure-activity relationships of stemphones, potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus.2008
- Author(s)
  Yamazaki, H., Koyama, N., mura, S. & Tomoda, H.
- Journal Title
  
  J. Antibiot. 61
  
  Pages: 426-441
- NAID
  10021928143
- Data Source
  KAKENHI-PROJECT-19710191
[Journal Article] (2008) Inhibition of lipid droplet accumulation in mouse macrophages by stemphone derivatives.2008
- Author(s)
  Koyama, N., Kobayashi, K., Yamazaki, H. & Tomoda, H.
- Journal Title
  
  J. Antibiot. 61
  
  Pages: 509-514
- Data Source
  KAKENHI-PROJECT-19710191
[Journal Article] Relative and absolute stereochemistry of quinadoline B, an inhibitor of lipid droplet synthesis in macrophages.2008
- Author(s)
  Koyama, N., Inoue, Y., Sekine, M., Hayakawa, Y., Homma, H., Omura, S. & Tomoda, H.
- Journal Title
  
  Org. Lett., 10
  
  Pages: 5273-5276
- Data Source
  KAKENHI-PROJECT-19710191
[Journal Article] Fungal isobisvertinol. a new inhibitor of lipid dropletaccumvilation in mouse macrophages2007
- Author(s)
  Koyama, N., et. al.
- Journal Title
  
  Org. Lett. 9
  
  Pages: 425-428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16073215
[Journal Article] Fungal isobisvertinol, a new inhibitor of lipid droplet accumulation in mouse macrophages.2007
- Author(s)
  N.Koyama et al.
- Journal Title
  
  Org. Lett. 9 (3)
  
  Pages: 425-428
- Data Source
  KAKENHI-PROJECT-16073215
[Journal Article] Spylidone, a novel inhibitor of lipid droplet accumulation in mouse macrophages produced by Phoma sp.FKI-1840.2005
- Author(s)
  Koyama, N. et al.
- Journal Title
  
  J.Antibiot. 58(5)
  
  Pages: 338-345
- Data Source
  KAKENHI-PROJECT-16073215
[Patent] ビフィドバクテリウム属細菌の線毛形成誘導用の組成物2019
- Inventor(s)
  大澤朗、西山啓太、岡田信彦、小山信裕、向井孝夫、供田洋ら
- Industrial Property Rights Holder
  大澤朗、西山啓太、岡田信彦、小山信裕、向井孝夫、供田洋ら
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-036309
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K05464
[Patent] 骨代謝阻害活性を有する新規化合物及びその製造方法2018
- Inventor(s)
  供田洋、小山信裕、大手聡、片桐岳信
- Industrial Property Rights Holder
  供田洋、小山信裕、大手聡、片桐岳信
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-231377
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K05464
[Patent] マイコバクテリウム・アビウム複合感染症に対する治療活性を有する新規化合物及びその製造方法2017
- Inventor(s)
  供田洋、小山信裕、金本昭彦、橋本絢子、小曽根郁子
- Industrial Property Rights Holder
  同左、北里大、OPバイオ社、JBIC
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-168404
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K07867
[Patent] MRSA 産生黄色色素の生成阻害能を示す新規化合物とその製造方法2011
- Inventor(s)
  供田洋、小山信裕、福田隆志
- Industrial Property Rights Holder
  学校法人北里大学
- Filing Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-23790020
[Patent] MRSA産生黄色色素の生成阻害能を示す新規化合物とその用途2011
- Inventor(s)
  供田洋、長光亨、福田隆志、小山信裕
- Industrial Property Rights Holder
  学校法人北里研究所
- Filing Date
  2011-10-12
- Data Source
  KAKENHI-PROJECT-21310146
[Patent] MRSA産生黄色色素の生成阻害能を示す新規化合物とその製造方法2011
- Inventor(s)
  供田洋、福田隆志、小山信裕
- Industrial Property Rights Holder
  学校法人北里研究所
- Filing Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-21310146
[Patent] 新規FKI-4905物質およびその製造方法2009
- Inventor(s)
  供田洋、小山信裕、増間碌郎、大村智
- Industrial Property Rights Holder
  学校法人北里学園
- Filing Date
  2009-03-03
- Data Source
  KAKENHI-PROJECT-19710191
[Patent] 新規FKI-4905物質およびその製造方法2009
- Inventor(s)
  供田洋, 小山信裕, 増間碌郎, 大村智
- Industrial Property Rights Holder
  学校法人北里学園
- Filing Date
  2009-03-03
- Data Source
  KAKENHI-PROJECT-19710191
[Patent] 新規FKI・1746-1およびFKI-1746・2物質並びにそれらの製造方法2008
- Inventor(s)
  供田洋, 小山信裕, 増間碌郎, 大村智
- Industrial Property Rights Holder
  北里学園
- Filing Date
  2008-02-05
- Data Source
  KAKENHI-PROJECT-16073215
[Presentation] 放線菌 KKTA-0263 株が生産する新規抗 MAC 剤に関する研究2021
- Author(s)
  曳間歩、供田洋、小山信裕
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K05464
[Presentation] 放線菌KKTA-0263株の生産する新規抗MAC剤に関する研究2021
- Author(s)
  曳間歩、供田洋、小山信裕
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-18K05464
[Presentation] Mycobacterium avium complex の感染細胞モデルを用いた既存薬の評価2020
- Author(s)
  細田莞爾、小山信裕、供田洋
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K05464
[Presentation] 真菌由来の oosporein のインフルエンザウイルス cap-snatching 反応阻害活性2020
- Author(s)
  小山信裕、新島綾、増尾詩乃、三尾遥、柴垣芳夫、奥脇暢、供田洋
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K05464
[Presentation] 海洋由来放線菌 OPMA90031 株が生産する rufomyazine の抗 MAC 活性2019
- Author(s)
  細田莞爾、長井賢一郎、小山信裕、金本昭彦、供田洋
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K05464
[Presentation] 真菌 Penicillium sp. BF-0343 株が産生する骨形成因子シグナル伝達阻害物質に関する研究2019
- Author(s)
  乙黒靖裕、宇都木俊、小山信裕、大手聡、片桐岳信、供田洋
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K05464
[Presentation] 天然由来化合物ライブラリーからの Mycobacterium abscessus 症に対する抗菌物質の探索2019
- Author(s)
  加藤航、小山信裕、供田洋
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K05464
[Presentation] 微生物資源からの抗酸菌症治療薬の開拓2018
- Author(s)
  小山信裕
- Organizer
  第101回日本細菌学会関東支部総会シンポジウム１結核・非結核性抗酸菌症研究の新しい展開
- Data Source
  KAKENHI-PROJECT-18K05464
[Presentation] 微生物代謝産物のネットワークを基盤とした新規天然物の探索2018
- Author(s)
  小山信裕
- Organizer
  理研シンポジウム高磁場・高感度NMR利活用促進のための天然物分野シンポジウム2018
- Invited
- Data Source
  KAKENHI-PROJECT-18K05464
[Presentation] 海洋由来放線菌 OPMA02852株の産生する抗MAC活性物質 steffimycin 類に関する研究2017
- Author(s)
  茂野聡、小山信裕、金本昭彦、供田洋
- Organizer
  第32回日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] 海洋由来放線菌 OPMA1245 株が産生する nosiheptide の抗 MAC 活性2017
- Author(s)
  細田莞爾、小山信裕、金本昭彦、供田洋
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] MSネットワーク手法を利用した Mycobacterium avium complex に対する新規抗菌物質の探索研究2017
- Author(s)
  細田莞爾、小山信裕、尾仲宏康、金本昭彦、供田洋
- Organizer
  第32回日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] 海洋由来放線菌が産生する Mycobacterium avium complex に対する活性物質の単離精製2017
- Author(s)
  細田莞爾、小山信裕、金本昭彦、供田洋
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-26
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] 抗 Rhizopus 剤 tanzawaic acid B のビオチン誘導体の合成及び結合タンパク質の解析2017
- Author(s)
  富永剛広、小山信裕、供田洋
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] Mass spectral library of microbial metabolomes for screening of antibiotics2017
- Author(s)
  Koyama N, Hosoda K, Onaka H, Kanamoto A, Tomoda H
- Organizer
  International Union of Microbiological Societies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] 微生物代謝産物探索へのネットワーク技術の活用2016
- Author(s)
  小山信裕
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] Molecular networking-guided discovery of new compounds from actinomycetes2016
- Author(s)
  Koyama N
- Organizer
  The 8thJapan-Korea Chemical Biology Symposium
- Place of Presentation
  Okinawa
- Year and Date
  2016-01-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] 天然由来化合物ライブラリーを基盤とした抗結核剤の探索2016
- Author(s)
  中原悠太、田中有理沙、郡司雅奈子、Delfly BABDJEL、山崎寛之、小山信裕、浪越通夫、供田洋
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] Mycobacterium avium complex に有効な化合物の探索系の構築2016
- Author(s)
  細田莞爾、八木瑛穂、内田龍児、小山信裕、供田洋
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] モレキュラーネットワーキングによる新規放線菌二次代謝産物の探索2015
- Author(s)
  小山信裕, Dimitrios J. Floros , Paul R. Jensen, Pieter C. Dorrestein
- Organizer
  第30回日本放線菌学会大会
- Place of Presentation
  富山
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] MSデータの新しい解析ツール「Molecular Networking」を利用した海洋放線菌からの新規二次代謝産物の探索2015
- Author(s)
  小山信裕
- Organizer
  第26回新薬創製談話会
- Place of Presentation
  静岡
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-15K07867
[Presentation] 微生物由来の新しい抗感染症剤の開拓とその標的分子の解析2013
- Author(s)
  供田洋、小山信裕
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台
- Year and Date
  2013-03-27
- Data Source
  KAKENHI-PROJECT-23790020
[Presentation] 放線菌由来 Cyslabdan は MRSA 細胞壁合成に関わる FemA を阻害する2013
- Author(s)
  小山信裕, Hans-Georg SAHL, 供田洋
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23790020
[Presentation] Mechanism of action of cyslabdan, a potentiator of ss-lactam drug activity against MRSA2012
- Author(s)
  Koyama N, Tokura Y, Tomoda H
- Organizer
  The 6th Korea-Japan Chemical Biology Symposium
- Place of Presentation
  Sapporo
- Year and Date
  2012-01-27
- Data Source
  KAKENHI-PROJECT-23790020
[Presentation] Mechanism of action of cyslabdan, a potentiator of β-lactam drug activity against MRSA2012
- Author(s)
  Koyama N et al
- Organizer
  The 6th Korea-Japan Chemical Biology Symposium
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-23790020
[Presentation] Inhibition of MRSA yellow pigment production by citridone A2012
- Author(s)
  Sakai K, Fukuda T, Koyama N, Tomoda H
- Organizer
  The 6th Korea-Japan Chemical Biology Symposium
- Place of Presentation
  Sapporo
- Year and Date
  2012-01-27
- Data Source
  KAKENHI-PROJECT-23790020
[Presentation] Mechanism of action of cyslabdan, a potentiator of β-lactam drug activity against MRSA2012
- Author(s)
  Koyama N, et al
- Organizer
  The 6th Korea-Japan Chemical Biology Symposium
- Place of Presentation
  Sapporo
- Year and Date
  2012-01-27
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] Selective anti-mycobacterial activity of fungal calpinactam, new aminoca prolactam peptide2011
- Author(s)
  Koyama N, et al
- Organizer
  ICDDT2011
- Place of Presentation
  Dubai, UAE
- Year and Date
  2011-02-10
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] 真菌の生産する新しい抗結核ペプチドcalpinactamの研究2011
- Author(s)
  小山信裕, ら
- Organizer
  第14回北里微生物アカデミー研究集会
- Place of Presentation
  相模原
- Year and Date
  2011-08-23
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] Discovery of Fungal Calpinactam, A New Anti-mycobacterial Agent2010
- Author(s)
  Koyama N
- Organizer
  The 5th Japan-Korea Chemical Biology Symposium
- Place of Presentation
  Busan, Korea
- Year and Date
  2010-01-27
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] 真菌Mortierella alpina FKI-4905株が生産する抗結核活性物質2010
- Author(s)
  小山信裕
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] Calpinactam, a New Anti-mycobacterial Agent, Produced by Mortierella alpina FKI-49052009
- Author(s)
  Koyama N
- Organizer
  49th ICAAC
- Place of Presentation
  San Francisco, USA
- Year and Date
  2009-09-15
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] イミペネムの抗MRSA活性増強剤cyslabdanの標的分子の解析2009
- Author(s)
  小山信裕
- Organizer
  第24回日本放線菌学会大会
- Place of Presentation
  秋田
- Year and Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-21310146
[Presentation] 投げ縄構造を有する抗結核ペプチドlariatinAの作用機序の解明2008
- Author(s)
  山下皓平,猪腰淳嗣,小山信裕,供田洋
- Organizer
  平成20年度AKPS研究集会
- Place of Presentation
  東京
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-19710191
[Presentation] Stemphone誘導体の生物活性研(1)MRSAに対するイミペネム活性増強2008
- Author(s)
  山崎寛之,小山信裕,大村智,供田洋
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19710191
[Presentation] 海洋由来真菌Aspergillus clavatonanicusFKI-1746株の生産する新規マクロファーシ脂肪滴蓄積阻害物質2008
- Author(s)
  小山信裕,井上勇佑,野中健一,山口裕一,増間碌郎,大村智,供田洋
- Organizer
  第11回マリンバイオテクノロジー学会大会
- Place of Presentation
  京都
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19710191
[Presentation] 石垣島土壌より分離されたStephanonectria sp. FKI-2703について2008
- Author(s)
  野中健一,増間碌郎,小山信裕,供田洋,大村智
- Organizer
  日本菌学会第52回大会
- Place of Presentation
  三重
- Year and Date
  2008-05-31
- Data Source
  KAKENHI-PROJECT-19710191
[Presentation] Potentiation of imipenem activity against methicillin-resistant staphylococcus aureus by stemphones2008
- Author(s)
  Yamazaki H, Koyama N, Omura S, Tomoda H
- Organizer
  The 4th Korea-Japan Chemical Biology Symposium
- Place of Presentation
  鬼怒川
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-19710191
[Presentation] 海洋由来真菌Aspergillus clavatonanicus FKI-1746株の生産する新規マクロファーシ脂肪滴蓄積阻害物質2008
- Author(s)
  小山信裕
- Organizer
  第11回マリンバイオテクノロジー学会大会
- Place of Presentation
  京都
- Year and Date
  2008-05-24
- Data Source
  KAKENHI-PROJECT-19710191
[Presentation] Stemphone誘導体の生物活性研(2)マクロファージ脂肪滴蓄積阻害活性2008
- Author(s)
  小山信裕,小林翔,山崎寛之,大村智,供田洋
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19710191
[Presentation] 微生物資源からのβ-ラクタム薬の抗MRSA活性増強物質の開拓2008
- Author(s)
  小山信裕,供田洋
- Organizer
  第53回ブドウ球菌研究会
- Place of Presentation
  東京
- Year and Date
  2008-09-19
- Data Source
  KAKENHI-PROJECT-19710191
[Presentation] Stemphone誘導体の生物活性研究(2)マクロファージ脂肪油蓄積阻害活性2008
- Author(s)
  小山信裕, ら
- Organizer
  日本薬学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-16073215
[Presentation] 微生物由来の新しい抗感染症剤の開拓とその標的分子の解析
- Author(s)
  供田　洋, 小山信裕
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23790020
[Presentation] 放線菌由来 Cyslabdan は MRSA 細胞壁合成に関わる FemA を阻害する
- Author(s)
  小山信裕, Hans-Georg SAHL, 供田洋
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790020

1. TOMODA Hiroshi (70164043)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. NAGAI Kenichiro (30321649)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. INOKOSHI Junji (30151640)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. UCHIDA Ryuji (60280632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAGAMITSU Toru (90300756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. UMEYAMA Hideaki (20050619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SATO Noriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Koyama Nobuhiro 小山 信裕

KOYAMA Nobuhiro 小山 信裕

Research Projects

Research Products

Co-Researchers

Discovery of anti-mycobacterial drug leads from microbial sourcesPrincipal Investigator

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Discovery of new anti-infectives based on chemical biologyPrincipal Investigator

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Development of anti-tuberculosis drugs based on calpinactam

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DEVELOPMENT OF NEW MICROBIAL AGENT RESTORING MRSA SUSCEPTIBILITYTO ss-LACATAM DRUGSPrincipal Investigator

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THE CHEMICAL BIOLOGY OF NEW MICROBIAL ANTI-INFECTIVE AGENTS

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DISCOVERY OF ANTI-INFECTIVE AGENTS AND THE DEVELOPMENT TO CHEMICAL BIOLOGYPrincipal Investigator

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脂質代謝を制御する機能分子プローブの創製

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[Journal Article] Penicillic acid congener, a new inhibitor of BMP-induced alkaline phosphatase activity in myoblasts, produced by the fungus Penicillium sp. BF-03432020

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[Journal Article] Quantitative analysis of selective glycosylation of saccharides with aromatic amines2020

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[Journal Article] Evaluation of anti-mycobacterial compounds in a silkworm infection model with Mycobacteroides abscessus2020

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[Journal Article] Steffimycin E, a new anti-mycobacterial agent against Mycobacterium avium complex, produced by Streptomyces sp. OPMA028522020

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[Journal Article] A new diketopiperazine-like inhibitor of bone morphogenetic protein-induced osteoblastic differentiation produced by marine-derived Aspergillus sp. BFM-00852020

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[Journal Article] MS network-based screening for new antibiotics discovery2019

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[Journal Article] Discovery of Nosiheptide, Griseoviridin, and Etamycin as Potent Anti-Mycobacterial Agents against Mycobacterium avium Complex2019

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Koyama Nobuhiro 小山信裕

KOYAMA Nobuhiro 小山信裕