Shirasaka Yoshiyuki 白坂善之

… Alternative Names

SHIRASAKA Yoshiyuki 白坂善之

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Researcher Number	60453833
Other IDs
External Links
Affiliation (Current)	2025: 昭和薬科大学, 薬学部, 教授 2025: 金沢大学, 薬学系, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 金沢大学, 薬学系, 准教授 2017 – 2018: 東京薬科大学, 薬学部, 准教授 2016: 東京薬科大学, 薬学部, 講師 2008 – 2013: Kanazawa University, 薬学系, 助教 2009: 金沢大, 薬学系, 助教 2007: 東京理科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological pharmacy
Keywords	Principal Investigator 経口吸収 / 薬物動態学 / 消化管 / トランスポーター / 薬学 / 生体分子 / 薬物間相互作用 / 消化管吸収 / モデリング＆シミュレーション / 代謝酵素 … More / 細胞・組織 / 組織透明化 / 量子ドット / 水分 / 代謝酵素・トランスポーター / 培養細胞 / 小腸モデル / 細胞培養 / 徐放性製剤 / 薬物動態・代謝学 … More Except Principal Investigator トランスポーター / 高尿酸血症 / 尿酸 / 胆汁中排泄 / 有機アニオン / NAD+ / 尿酸低下療法 / 尿酸結合タンパク質 / 炎症 / 痛風 / CD38 / 蛍光診断 / 光力学診断 / 薬物排泄 / プロトポルフォリン / 光力学療法 / フェロキラターゼ / 化学療法 / プロトポルフィリン / アミノレブリン酸 / オルガネラ / 胆汁うっ滞 / BSEP / 肝細胞 / MRP2 / 可視化 / 薬物毒性 / in vitro発現系 / OAT / 薬物間相互作用 / ロサルタン / ベンズブロマロン / 尿酸排泄促進薬 / 発現系 / URATv1 / URAT1 / 再吸収 / 尿酸値変動 / 消化管 / 腎臓 / ナフシリン / βラクタム抗生物質 / 有機アニオントランスポーター / 肝臓 / 種差 / 体内動態 / OATP / 肝毒性 / 動物種差 / 肝取り込み / 薬物動態学 Less

Establishment of predictive approach of oral drug absorption based on gastrointestinal imaging analysis using quantum dot and tissue clearing technologiesPrincipal Investigator
- Principal Investigator
  
  白坂善之
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
尿酸結合タンパク質CD38を介した尿酸による炎症応答調節
- Principal Investigator
  
  玉井郁巳
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kanazawa University
Quantitative Prediction of Oral Drug Absorption by Kinetically Analyzing Gastrointestinal Water DynamicsPrincipal Investigator
- Principal Investigator
  
  Shirasaka Yoshiyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
Evaluation of Oral Drug Absorption by Developing In Vitro Culture System for Intestinal Villus CellsPrincipal Investigator
- Principal Investigator
  
  Shirasaka Yoshiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Regional Difference in the Effect of Influx/Efflux Transporters and Metabolic Enzymes on Intestinal Drug AbsorptionPrincipal Investigator
- Principal Investigator
  
  SHIRASAKA Yoshiyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Clarification and evaluation of regulation mechanism of uric acid
- Principal Investigator
  
  TAMAI Ikumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
細胞内オルガネラ膜トランスポーター活性の定量的可視化による薬物の細胞毒性評価
- Principal Investigator
  
  玉井郁巳
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Quantitative Evaluation of the Effect of Influx/Efflux Transporters on Oral Drug AbsorptionPrincipal Investigator
- Principal Investigator
  
  SHIRASAKA Yoshiyuki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Evaluation of molecular mechanisms of tumor-specific protoporphyr in accumulation induced by 5-aminolevulinic acid
- Principal Investigator
  
  NAKANISHI Takeo
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  Kanazawa University
吸収/排泄型トランスポーターの優位性に基づいた消化管吸収性評価システムの構築Principal Investigator
- Principal Investigator
  
  白坂善之
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Species difference in hepatic disposition of organic anions
- Principal Investigator
  
  TAMAI Ikumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
  Tokyo University of Science

[Journal Article] Functional identification of soluble uric acid as an endogenous inhibitor of CD382024
- Author(s)
  Wen S, Arakawa H, Yokoyama S, Shirasaka Y, Higashida H, Tamai I.
- Journal Title
  
  eLife
  
  Volume: none Pages: 1-1
- DOI
  10.7554/elife.96962.1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18181, KAKENHI-PROJECT-22K19372, KAKENHI-PROJECT-21H02641
[Journal Article] Magnitude of Fruit Juice–Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices2024
- Author(s)
  Takemura Miyuki、Inoue Katsuhisa、Tamai Ikumi、Shirasaka Yoshiyuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 1 Pages: 72-78
- DOI
  10.1248/bpb.b23-00490
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-01-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-22KJ1465
[Journal Article] Quantitative analysis of gastrointestinal fluid absorption and secretion to estimate luminal fluid dynamics in rats2023
- Author(s)
  Funai Yuta、Ichijo Kazuki、Suzuki Satoru、Tateishi Yuta、Inoue Katsuhisa、Tamai Ikumi、Shirasaka Yoshiyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41598-023-44742-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07165
[Journal Article] Food effects on gastrointestinal physiology and drug absorption2023
- Author(s)
  Kambayashi Atsushi、Shirasaka Yoshiyuki
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 48 Pages: 100488-100488
- DOI
  10.1016/j.dmpk.2022.100488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07165
[Journal Article] Quantitative analysis of the impact of membrane permeability on intestinal first‐pass metabolism of CYP3A substrates2023
- Author(s)
  Yasugi Yugo、Shirasaka Yoshiyuki、Tamai Ikumi
- Journal Title
  
  Biopharmaceutics & Drug Disposition
  
  Volume: 45 Issue: 1 Pages: 3-14
- DOI
  10.1002/bdd.2379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07165
[Journal Article] Quantitative Analysis of Gastrointestinal Water Dynamics by Means of a Physiologically Based Fluid Kinetic Model2023
- Author(s)
  Suzuki Satoru、Inoue Katsuhisa、Tamai Ikumi、Shirasaka Yoshiyuki
- Journal Title
  
  The AAPS Journal
  
  Volume: 25 Issue: 3
- DOI
  10.1208/s12248-023-00809-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21J12535
[Journal Article] Multiple Transport Mechanisms Involved in the Intestinal Absorption of Metformin: Impact on the Nonlinear Absorption Kinetics2022
- Author(s)
  Shirasaka Yoshiyuki、Seki Maria、Hatakeyama Marie、Kurokawa Yuko、Uchiyama Hiroki、Takemura Miyuki、Yasugi Yugo、Kishimoto Hisanao、Tamai Ikumi、Wang Joanne、Inoue Katsuhisa
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 111 Issue: 5 Pages: 1531-1541
- DOI
  10.1016/j.xphs.2022.01.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-22KJ1465
[Journal Article] Effect of ingested fluid volume and solution osmolality on intestinal drug absorption: Impact on drug interaction with beverages2022
- Author(s)
  Funai Yuta、Takemura Miyuki、Inoue Katsuhisa、Shirasaka Yoshiyuki
- Journal Title
  
  European Journal of Pharmaceutical Sciences
  
  Volume: 172 Pages: 106136-106136
- DOI
  10.1016/j.ejps.2022.106136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-22KJ1465, KAKENHI-PROJECT-21J12536
[Journal Article] Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening2022
- Author(s)
  Moeno Kadoguchi, Hiroshi Arakawa, Ryokichi Honda, Kazuki Hotta, Yoshiyuki Shirasaka, Yoshiharu Deguchi, Ikumi Tamai
- Journal Title
  
  Pharmaceutical Research
  
  Volume: - Issue: 7 Pages: 1549-1559
- DOI
  10.1007/s11095-022-03223-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16039, KAKENHI-PROJECT-20K07165, KAKENHI-PLANNED-20H05745
[Journal Article] SLC46A3 is a lysosomal proton-coupled steroid conjugate and bile acid transporter involved in transport of active catabolites of T-DM12022
- Author(s)
  Tomabechi Ryuto、Kishimoto Hisanao、Sato Taeka、Saito Naoki、Kiyomiya Keisuke、Takada Tappei、Higuchi Kei、Shirasaka Yoshiyuki、Inoue Katsuhisa
- Journal Title
  
  PNAS Nexus
  
  Volume: 1 Issue: 3
- DOI
  10.1093/pnasnexus/pgac063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-20H00568
[Journal Article] Identification of 5-Carboxyfluorescein as a Probe Substrate of SLC46A3 and Its Application in a Fluorescence-Based In Vitro Assay Evaluating the Interaction with SLC46A32022
- Author(s)
  Tomabechi Ryuto、Miyasato Miki、Sato Taeka、Takada Tappei、Higuchi Kei、Kishimoto Hisanao、Shirasaka Yoshiyuki、Inoue Katsuhisa
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 1 Pages: 491-499
- DOI
  10.1021/acs.molpharmaceut.2c00741
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-20H00568
[Journal Article] The Glycosylated N-Terminal Domain of MUC1 Is Involved in Chemoresistance by Modulating Drug Permeation Across the Plasma Membrane2022
- Author(s)
  Miyazaki Kaori、Kishimoto Hisanao、Kobayashi Hanai、Suzuki Ayaka、Higuchi Kei、Shirasaka Yoshiyuki、Inoue Katsuhisa
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 103 Issue: 3 Pages: 166-175
- DOI
  10.1124/molpharm.122.000597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06695
[Journal Article] Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine2021
- Author(s)
  Kishimoto Hisanao、Miyazaki Kaori、Tedzuka Hiroshi、Ozawa Ryosuke、Kobayashi Hanai、Shirasaka Yoshiyuki、Inoue Katsuhisa
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 21 Pages: 6396-6396
- DOI
  10.3390/molecules26216396
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K06678, KAKENHI-PROJECT-21K06695
[Journal Article] Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation2021
- Author(s)
  Takemura Miyuki、Tanaka Yuki、Inoue Katsuhisa、Tamai Ikumi、Shirasaka Yoshiyuki
- Journal Title
  
  Journal of Pharmaceutical Health Care and Sciences
  
  Volume: 7 Issue: 1 Pages: 29-29
- DOI
  10.1186/s40780-021-00212-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-22KJ1465
[Journal Article] Model Analysis of the Apparent Saturation Kinetics of Purine Nucleobase Uptake in Cells co-Expressing Transporter and Metabolic Enzyme2021
- Author(s)
  Suzuki Satoru、Inoue Katsuhisa、Tamai Ikumi、Shirasaka Yoshiyuki
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 38 Issue: 9 Pages: 1585-1592
- DOI
  10.1007/s11095-021-03086-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21J12535, KAKENHI-PROJECT-20K07165
[Journal Article] 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents2021
- Author(s)
  Konno S、Kobayashi K、Senda M、Funai Y、Seki Y、Tamai I、Schakel L、Sakata K、Pillaiyar T、Taguchi A、Taniguchi A、Gutschow M、Muller CE.、Takeuchi K、Hirohama M、Kawaguchi A、Kojima M、Senda T、Shirasaka Y、Kamitani W、Hayashi Y
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 65 Issue: 4 Pages: 2926-2939
- DOI
  10.1021/acs.jmedchem.1c00665
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07137, KAKENHI-PROJECT-20K22723, KAKENHI-PROJECT-19H03475, KAKENHI-PROJECT-21J12536, KAKENHI-PROJECT-20K07165, KAKENHI-PROJECT-21K07036
[Journal Article] Effect of osmolality on the pharmacokinetic interaction between apple juice and atenolol in rats.2019
- Author(s)
  Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto, and Katsuhisa Inoue.
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 47 Issue: 4 Pages: 386-391
- DOI
  10.1124/dmd.118.084483
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15165
[Journal Article] Osmolality of Orally Administered Solutions Influences Luminal Water Volume and Drug Absorption in Intestine2017
- Author(s)
  Ichijo Kazuki、Oda Rika、Ishihara Marika、Okada Ren、Moteki Yuri、Funai Yuta、Horiuchi Takuya、Kishimoto Hisanao、Shirasaka Yoshiyuki、Inoue Katsuhisa
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 106 Issue: 9 Pages: 2889-2894
- DOI
  10.1016/j.xphs.2017.04.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15165
[Journal Article] Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B1.2014
- Author(s)
  Shirasaka Y, Mori T, Murata Y, Nakanishi T, and Tamai I.
- Journal Title
  
  Pharm Res.
  
  Volume: In Press Issue: 8 Pages: 2035-2043
- DOI
  10.1007/s11095-014-1305-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Substrate- and dose-dependent drug interactions with grapefruit juice caused by multiple binding sites on OATP2B12014
- Author(s)
  Shirasaka Y, Mori T, Murata Y, Nakanishi T, and Tamai I
- Journal Title
  
  Pharm Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Major active components in grapefruit, orange and apple juices responsible for OATP2B1-mediated drug interactions2013
- Author(s)
  Shirasaka Y, Shichiri M, Mori T, Nakanishi T, and Tamai I
- Journal Title
  
  J Pharm Sci
  
  Volume: 102(9) Pages: 3418-3426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions.2013
- Author(s)
  Shirasaka Y, Chang SY, Grubb MF, Peng CC, Thummel KE, Isoherranen N, Rodrigues AD.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 41 Issue: 8 Pages: 1566-1574
- DOI
  10.1124/dmd.112.049940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1- mediated drug absorption2013
- Author(s)
  Shirasaka Y, Shichiri M, Murata Y, Mori T, Nakanishi T, and Tamai I
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41(3) Pages: 615-621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions2013
- Author(s)
  Shirasaka Y, Sager JE, Lutz JD, Davis C, and Isoherranen N
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41(7) Pages: 1414-1424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Major active components in grapefruit, orange and apple juices responsible for OATP2B1-mediated drug interactions.2013
- Author(s)
  Shirasaka Y., Shichiri M, Nakanishi T., and Tamai I.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 102 Issue: 1 Pages: 280-288
- DOI
  10.1002/jps.23357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions.2013
- Author(s)
  Shirasaka Y, Sager JE, Lutz JD, Davis C, and Isoherranen N.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 41 Issue: 7 Pages: 1414-1424
- DOI
  10.1124/dmd.113.051722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Rodrigues AD. Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism : impact on modeling CYP3A-mediated drug-drug interactions2013
- Author(s)
  Shirasaka Y, Chang SY, Grubb MF, Peng CC, Thummel KE, Isoherranen N
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 41(8) Pages: 1566-1574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Major active components in grapefruit, orange and apple juices responsible for OATP2B1-mediated drug interactions.2013
- Author(s)
  Shirasaka Y, Shichiri M, Mori T, Nakanishi T, and Tamai I.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 102 Issue: 9 Pages: 3418-3426
- DOI
  10.1002/jps.23653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption.2013
- Author(s)
  Shirasaka Y., Shichiri M, and Tamai I.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 41 Issue: 3 Pages: 615-621
- DOI
  10.1124/dmd.112.049635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid2013
- Author(s)
  Kugai M, Uchiyama K, Tsuji T, Yoriki H, Fukui A, Qin Y, Higashimura Y, Mizushima K, Yoshida N, Katada K, Kamada K, Handa O, Takagi T, Konishi H, Yagi N, Yoshikawa T, Shirasaka Y, Tamai I, Naito Y, and Itoh Y
- Journal Title
  
  Cell Physiol Biochem
  
  Volume: 32(4) Pages: 942-950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid.2013
- Author(s)
  Kugai M, Uchiyama K, Tsuji T, Yoriki H, Fukui A, Qin Y, Higashimura Y, Mizushima K, Yoshida N, Katada K, Kamada K, Handa O, Takagi T, Konishi H, Yagi N, Yoshikawa T, Shirasaka Y, Tamai I, Naito Y, and Itoh Y.
- Journal Title
  
  Cell Physiol Biochem.
  
  Volume: 32 Issue: 4 Pages: 942-950
- DOI
  10.1159/000354497
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175, KAKENHI-PROJECT-25750050
[Journal Article] Involvement of Functional Groups on the Surface of Carboxyl Group-Terminated Polyamidoamine Dendrimers Bearing Arbutin in Inhibition of Na(+)/Glucose Cotransporter 1 (SGLT1)-Mediated d-Glucose Uptake2012
- Author(s)
  Sakuma S, Kanamitsu S, Teraoka Y, Masaoka Y, Kataoka M, Yamashita S, Shirasaka Y, Tamai I, Muraoka M, Nakatsuji Y, Kida T, and Akashi M
- Journal Title
  
  Mol Pharm
  
  Volume: 9(4) Pages: 922-929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide.2012
- Author(s)
  Arakawa H., Shirasaka Y., Haga M., Nakanishi T., and Tamai I.
- Journal Title
  
  Biopharm Drug Dispos.
  
  Volume: 33 Issue: 6 Pages: 332-341
- DOI
  10.1002/bdd.1809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites2012
- Author(s)
  Shirasaka Y, Mori T, Shichiri M, Nakanishi T, and Tamai I
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 27(3) Pages: 360-364
- NAID
  130004463259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites.2012
- Author(s)
  Shirasaka Y., Mori T., Shichiri M., Nakanishi T., and Tamai I.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: In press
- NAID
  130004463259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Involvement of Functional Groups on the Surface of Carboxyl Group-Terminated Polyamidoamine Dendrimers Bearing Arbutin in Inhibition of Na(+)/Glucose Cotransporter 1 (SGLT1)-Mediated d-Glucose Uptake.2012
- Author(s)
  Sakuma S., Kanamitsu S., Teraoka Y., Masaoka Y., Kataoka M., Yamashita S., Shirasaka Y., Tamai I., Muraoka M., Nakatsuji Y., Kida T., and Akashi M.
- Journal Title
  
  Mol Pharm.
  
  Volume: 9 Pages: 922-929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a52012
- Author(s)
  Arakawa H, Shirasaka Y, Haga M, Nakanishi T, and Tamai I
- Journal Title
  
  Biopharm Drug Dispos
  
  Volume: 33(6) Pages: 332-341
- NAID
  120004997009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] The effects of the SLCO2B1 c.1457C &gt ; T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans.2011
- Author(s)
  Imanaga J., Shirasaka Y.(他8名,7番目)
- Journal Title
  
  Pharmacogenet Genomics. 21
  
  Pages: 84-93
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Intestinal Absorption of HMG-CoA Reductase Inhibitor Pitavastatin Mediated by Organic Anion Transporting Polypeptide and P-Glycoprotein/Multidrug Resistance 12011
- Author(s)
  Shirasaka Y., Suzuki K.(他3名,1番目)
- Journal Title
  
  Drug Metab Pharmacokinet. 26
  
  Pages: 171-179
- NAID
  130004463175
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.2011
- Author(s)
  Shirasaka Y., Suzuki K.(他2名,1番目)
- Journal Title
  
  J Pharm Sci. In press
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Quantitative time-lapse imaging (QTLI)-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug associated protein 2, in sandwich-cultured rat hepatocytes2011
- Author(s)
  Takeo Nakanishil, Yuta Shibuel, Yoko Fukuyamal, Kenji Yoshida2, Hajime Fukudal, Yoshiyuki Shirasakal, Ikumi Tamail, 2
- Journal Title
  
  Drug Metab.Dispos.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.2011
- Author(s)
  Shirasaka Y., Suzuki K., Nakanishi T., and Tamai I.
- Journal Title
  
  J Pharm Sci
  
  Volume: 100 Issue: 9 Pages: 3843-3853
- DOI
  10.1002/jps.22586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590175
[Journal Article] Identification and functional characterization of uric acid transporter Uratl (Slc22a12) in rats.2011
- Author(s)
  Sato M, Wakayama T, Mamada H, Shirasaka Y, Nakanishi T, Tamai I.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390044
[Journal Article] Intestinal Absorption of HMG-CoA Reductase Inhibitor Pitavastatin Mediated by Organic Anion Transporting Polypeptide and P-Glycoprotein/Multidrug Resistance 1.2011
- Author(s)
  Shirasaka Y, Suzuki K, Shichiri M, Nakanishi T, Tamai I.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: in press
- NAID
  130004463175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Intestinal Absorption Mechanism of Tebipenem Pivoxil, a Novel Oral Carbapenem : Involvement of Human OATP Family in Apical Membrane Ti-ansport.2011
- Author(s)
  Kato K., Shirasaka Y., Kuraoka E., Kikuchi A., Iguchi M., Suzuki H., Shirasaka S., Kurosawa T., Tamai I.
- Journal Title
  
  Mol.Pharm
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 12011
- Author(s)
  Yoshiyuki Shirasaka
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: (In press)
- NAID
  130004463175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Identification and functional characterization of uric acid transporter Urat1(Slc22a12) in rats2011
- Author(s)
  Sato M., Wakayama T., Mamada H., Shirasaka Y., Nakanishi T., Tamai I.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1808(6) Pages: 1441-1447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390044
[Journal Article] Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans2011
- Author(s)
  Nakanishi T, Haruta T, Shirasaka Y, Tamai I
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 39(1) Issue: 1 Pages: 117-22
- DOI
  10.1124/dmd.110.035402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390044
[Journal Article] Differential effect of grapefruit juice on intestinal absorption of statins due to inhihition of organic anion transporting polypeptide and/or P-glycoprotein2011
- Author(s)
  Yoshiyuki Shirasaka
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Functional characterization of apical transporters expressed in rat proximal tubular cells(PTCs) in primary culture2011
- Author(s)
  Nakanishi T., Fukushi A., Sato M., Yoshifuji M., Gose T., Shirasaka Y., Ohe K., Kobayashi M., Kawai K., Tamai I.
- Journal Title
  
  Mol Pharm
  
  Volume: 8(6) Issue: 6 Pages: 2142-50
- DOI
  10.1021/mp200096r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390044
[Journal Article] Hepatic Uptake of {gamma}-Butyrobetaine, a Precursor of Carnitine Biosynthesis, in Rats2010
- Author(s)
  Fujita M, Nakanishi T, Shibue Y, Kobayashi D, Moseley RH, Shirasaka Y, Tamai I.
- Journal Title
  
  Am.J.Physiol.Gastrointest Liver Physiol (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390044
[Journal Article] Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat.2010
- Author(s)
  Shirasaka Y., Kuraoka E.(他4名,1番目)
- Journal Title
  
  J Pharmacol Exp Ther. 332
  
  Pages: 181-189
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide2010
- Author(s)
  Yoshiyuki Shirasaka
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 27 Pages: 2141-2149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22 A7)2010
- Author(s)
  Sato M., Mamada H., Anzai N., Shirasaka Y., Nakanishi T., Tamai I.
- Journal Title
  
  Biol.Pharm.Bull. 33
  
  Pages: 498-503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390044
[Journal Article] Involvement of choline transporter-like(CTL)proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine syntesis via increased choline uptake.2010
- Author(s)
  Nakamura R., Ishiguro N., Oyabu M., Nakanishi T., Shirasaka Y., Maeda T., Tamai I.
- Journal Title
  
  Biol.Pharm.Bull. 33(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Transport of ipratropium, an anti-chronic obstructive pulmonary diseasedrug, is mediated by organic cat ionlcarnitine transporters in human bronchial epithelial cells : implications for carrier-mediated pulmonary absorption.2010
- Author(s)
  Nakamura T., Nakanishi T., Haruta T., Shirasaka Y., Keogh JP., Tamai I.
- Journal Title
  
  Mol.Phann.
  
  Volume: 7 Pages: 187-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Hepatic Uptake of {gamma}-Butyrobetaine, a Precursor of Carnitine Biosynthesis, in Rats.2010
- Author(s)
  Fujita M, Nakanishi T, Shibue Y, Kobayashi D, Moseley RH, Shirasaka Y, Tamai I.
- Journal Title
  
  Am.J.Physiol.Gastrointest Liver Physiol. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Quantitation of Talinolol in Rat Plasma By LC-MS-MS.2010
- Author(s)
  Li Y., Shirasaka Y., Langguth P.Tamai I
- Journal Title
  
  J.Chromatogr Sci.
  
  Volume: 48 Pages: 367-370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Renal Secretion of Uric Acid by Organic Anion Transporter 2 (OAT2/SLC22A7) in Human2010
- Author(s)
  Sato M., Mamada H., Anzai N., Shirasaka Y., Nakanishi T., Tamai I.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 33 Issue: 3 Pages: 498-503
- DOI
  10.1248/bpb.33.498
- NAID
  130000248105
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390044
[Journal Article] Model analysis of the Concentration-dependent permeability of P-gp substrates.2010
- Author(s)
  Tachibana T., Shirasaka Y.(他5名,5番目)
- Journal Title
  
  Pharm Res. 27
  
  Pages: 442-446
- NAID
  130005024251
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide.2010
- Author(s)
  Shirasaka Y., Suzuki K., Nakanishi T., Tamai I.
- Journal Title
  
  Pharw.Res.
  
  Volume: 27 Pages: 2141-2149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Quantitation of talinolol in rat plasma by LC-MS-MS.2010
- Author(s)
  Li Y., Shirasaka Y.(他2名,2番目)
- Journal Title
  
  J Chromatogr Sci. 48
  
  Pages: 367-370
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Langguth P., Tamai I. : Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat.2010
- Author(s)
  Shirasaka Y., Kuraoka E., Spahn-Langguth H., Nakanishi T.
- Journal Title
  
  J.Pharmacol.Exp.Ther
  
  Volume: 332 Pages: 181-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Transport of ipratropium, an anti-chronic obstructive pulmonary disease(COPD)drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells : Implications for carrier-mediated pulmonary absorption.2010
- Author(s)
  Nakamura T, Nakanishi T, Haruta T, Shirasaka Y, Keogh JP, Tamai I.
- Journal Title
  
  Molecular Pharmaceutics 7
  
  Pages: 187-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7)2010
- Author(s)
  Sato M., Mamada H., Anzai N., Shirasaka Y., Nakanishi T., Tamai I.
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: 33(3) Pages: 498-503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390044
[Journal Article] Intestinal Absorption Mechanism of Tebipenem Pivoxil, a Novel Oral Carbapenem : Involvement of Human OATP Family in Apical Membrane Transport.2010
- Author(s)
  Kato K., Shirasaka Y.(他7名,2番目)
- Journal Title
  
  Mol Pharm. 7
  
  Pages: 1747-1756
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Involvement of choline Iransporter-like (CTL) proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine syniesis via increased choline uptake.2010
- Author(s)
  Nakamura R., Ishigaro N., Oyabu M., Nakanishi T., Shirasaka Y., Maeda T., Tamai I
- Journal Title
  
  Biol Pharm.Bull.
  
  Volume: 33(4) Pages: 691-696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat2010
- Author(s)
  Yoshiyuki Shirasaka
- Journal Title
  
  The Journal of pharmacology and experimental th erapeutics 332
  
  Pages: 181-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Intestinal Absorption of HMG-CoA Reductase Inhibitor Pravastatin Mediated by Organic Anion Transporting Polypeptide.2010
- Author(s)
  Shirasaka Y., Suzuki K.(他2名,1番目)
- Journal Title
  
  Pharm Res. 27
  
  Pages: 2141-2149
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Concentration-dependent effect of naringin on intestinal absorption of β_1-adrenoceptor antagonist talinolol mediated by P-glycoprotein and organic anion transporting polypeptide (Oatp)2009
- Author(s)
  Yoshiyuki Shirasaka
- Journal Title
  
  Pharmacetical Research 26
  
  Pages: 560-567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890082
[Journal Article] Hepatic Uptake of{ gamma}-Butyrobetaine, a Precursor of Carnitine Biosynthesis2009
- Author(s)
  Fujita M., Nakanishi T., Shibue Y., Kobayashi D., Moseley RH., Shirasaka Y., Tamai I.
- Journal Title
  
  Gastrointest Liver Physiol
  
  Volume: 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390044
[Journal Article] Concentration-dependent effect of naringin on intestinal absorption of betal-adrenoreceptor antagonist talinolol mediated by P-glycoprotein and organic anion transporting Polypeptide(Oatp).2009
- Author(s)
  Shirasaka Y, Li Y, Shibue Y, Kuraoka E, Spahn-Langguth H, Kato Y, Langguth P, Tamai I.
- Journal Title
  
  Pharm.Res. 26
  
  Pages: 560-570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Oseltamivir (Tamiflu^<TM>) is a substrate of PEPT1.2009
- Author(s)
  Ogihara T, Kano T, Wagatsuma T, Wada S, Yabuuchi H, Enomoto S, Morimoto K, Shirasaka Y, Kobayashi S, Tamai I.
- Journal Title
  
  Drug Metab.Dispos. 37
  
  Pages: 1671-1681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659038
[Journal Article] Concentration-dependent effect of naringin on intestinal absorption of ・1-adrenoceptor antagonist talinolol mediated by P-glycoprotein and organic anion transporting polypeptide (Oatp).2009
- Author(s)
  Shirasaka Y., Li Y.(他6名,1番目)
- Journal Title
  
  Pharm Res. 26
  
  Pages: 560-567
- Data Source
  KAKENHI-PROJECT-21790147
[Journal Article] Organic Anion Transporter OAT1 Is Involved in Renal Handling of Citrulline2009
- Author(s)
  Nakakariya M., Shima Y., Shirasaka Y., Mitsuoka K., Nakanishi T., Tamai I.
- Journal Title
  
  Am. J. Physiol
  
  Volume: 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390044
[Journal Article] Organic Anion Transporter OAT1 Is Involved in Renal Handling of Citrulline2009
- Author(s)
  Nakakariya M, Shima Y, Shirasaka Y, Mitsuoka K, Nakanishi T, Tamai I.
- Journal Title
  
  Am.J.Physiol.Renal Physiol. 297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390044
[Presentation] セロトニン動態/腸内細菌叢に起因した薬物性消化器毒性発現とその個体間変動2024
- Author(s)
  白坂善之
- Organizer
  日本薬学会第144年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物-飲料間相互作用に及ぼす浸透圧およびOATPの影響とその寄与解析2023
- Author(s)
  竹村美由記、白坂善之、玉井郁巳
- Organizer
  第33回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物吸収動態シミュレーションがもたらす経口特殊製剤の適正使用: 投与製剤で変わるCYP3A/P-gpの影響2023
- Author(s)
  白坂善之
- Organizer
  第33回日本医療薬学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] セロトニン動態/腸内細菌叢に起因した薬物性消化器毒性発現機構の解明2023
- Author(s)
  浅地英、白坂善之、鮒井悠汰、関裕太、番場琴音、玉井郁巳
- Organizer
  第50回日本毒性学会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物の大腸吸収動態特性解析とその制御因子の同定2023
- Author(s)
  廣﨑真帆、白坂善之、八杉優護、村山枝美果、加藤由美、岩竹真弓、湯川博、玉井郁巳
- Organizer
  日本薬学会北陸支部第135回例会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 消化管内水分挙動に起因した薬物-飲料間相互作用とその小児特性解析2023
- Author(s)
  石井智貴、白坂善之、堀田和葵、吉島明日風、玉井郁巳
- Organizer
  日本医療薬学会第6回フレッシャーズ・カンファランス
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] Quantitative analysis of the effect of absorption characteristics on intestinal P-gp-mediated drug-drug interactions2023
- Author(s)
  Ryo Tamura, Yoshiyuki Shirasaka, Marina Naoi, Masanobu Sato, Ikumi Tamai
- Organizer
  2023 ICCP450/JSSX International Joint meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物の胃吸収動態および小腸初回通過代謝に及ぼす摂取水分量の影響2023
- Author(s)
  八杉優護、白坂善之、森脇俊哉、玉井郁巳
- Organizer
  第17回次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 溶液浸透圧に起因した薬物-飲食物間相互作用とそのリスク評価基準の確立2023
- Author(s)
  丸谷明香音、白坂善之、竹村美由記、日野太崇、玉井郁巳
- Organizer
  第17回次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] P-gp基質/阻害薬の消化管吸収動態解析に基づく薬物間相互作用リスク評価2023
- Author(s)
  直井麻里奈、白坂善之、田村諒、佐藤正延、玉井郁巳
- Organizer
  第44回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 大腸由来オルガノイドを活用した薬物性消化器毒性予測法の確立 -セロトニン動態に起因した体液分泌機構解析に基づいて2023
- Author(s)
  番場琴音、白坂善之、鮒井悠汰、浅地英、大島浩子、大島正伸、玉井郁巳
- Organizer
  第50回日本毒性学会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] セロトニン動態と腸内細菌叢の相互作用に起因した薬物性消化器毒性発現機構の解明2023
- Author(s)
  浅地英、白坂善之、鮒井悠汰、関裕太、番場琴音、玉井郁巳
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] Effect of ingested water volume on gastric drug absorption and disposition in humans2023
- Author(s)
  Yugo Yasugi, Yoshiyuki Shirasaka, Toshiya Moriwaki, Ikumi Tamai
- Organizer
  2023 ICCP450/JSSX International Joint meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] Soluble uric acid is an endogenous inhibitor of CD2382023
- Author(s)
  Wen S, Arakawa H, Ypkoyama S, Shirasaka Y, Higashida H, Tamai I
- Organizer
  2023 American College of Rheumatology Covergence
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18181
[Presentation] Physiological Perspective: Establishment and application of PBPK absorption model incorporating gastrointestinal fluid dynamics2023
- Author(s)
  Yoshiyuki Shirasaka
- Organizer
  2023 ICCP450/JSSX International Joint meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] Specific binding of uric acid to to NDFIP1 associates with hyperuricemia-induced ferroptosis2023
- Author(s)
  Zhu Q, Arakawa H, Isozumi N, Shirasaka Y, Mori E, Tamai I
- Organizer
  2023 American College of Rheumatology Covergence
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18181
[Presentation] 薬物の胃吸収動態に及ぼす水分摂取量の影響2023
- Author(s)
  八杉優護、白坂善之、森脇俊哉、玉井郁巳
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] P-gp基質/阻害薬の消化管吸収動態を考慮した薬物間相互作用リスク解析2023
- Author(s)
  直井麻里奈、白坂善之、田村諒、佐藤正延、玉井郁巳
- Organizer
  第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 消化管内浸透圧/水分挙動の小児感受性とその薬物吸収動態への影響2023
- Author(s)
  吉島明日風、白坂善之、堀田和葵、石井智貴、出口淳、玉井郁巳
- Organizer
  日本薬学会北陸支部第135回例会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 第17回次世代を担う若手医療薬科学シンポジウム2023
- Author(s)
  堀田和葵、白坂善之、石井智貴、吉島明日風、玉井郁巳
- Organizer
  消化管内浸透圧/水分挙動に起因した薬物吸収動態変動とその小児特性解析
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] メトホルミンによるトランスポーターを介したグルコースの消化管吸収/排泄動態の変動2023
- Author(s)
  荻さやか、白坂善之、竹村美由記、玉井郁巳
- Organizer
  第33回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物吸収動態学超入門：これだけは押さえておきたい経口吸収のキホン2022
- Author(s)
  白坂善之
- Organizer
  日本薬物動態学会研修会「薬物動態学の基礎講座シリーズ」
- Invited
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] CYP3A基質/阻害薬の消化管吸収動態解析に基づく薬物間相互作用リスク評価2022
- Author(s)
  鈴木悟、白坂善之、玉井郁巳
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] Quantitative Analysis of the Impact of Controlled-Release Formulation on Oral Absorption and Bioavailability of P-gp/CYP3A4 Substrates2022
- Author(s)
  Yoshiyuki SHIRASAKA, Emika Murayama, Yugo Yasugi, Satoru Suzuki, Peter Langguth, Ikumi Tamai
- Organizer
  4th International Symposium on BA/BE of Oral Drug Product
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 膜透過性/代謝活性の相互干渉に起因した薬物の消化管初回通過代謝とその定量的解析2022
- Author(s)
  八杉優護、白坂善之、鈴木悟、玉井郁巳
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] Quantitative analysis of the effect of controlled-release formulation on the gastrointestinal absorption of CYP3A4 substrate drugs using PBPK absorption model2022
- Author(s)
  Emika Murayama, Yoshiyuki Shirasaka, Satoru Suzuki, Ikumi Tamai
- Organizer
  第37回日本薬物動態学会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] SARS coronavirus 3CL protease inhibitors with an electrophilic aryl-ketone warhead2022
- Author(s)
  S. Konno, K. Kobayashi, M. Senda, Y. Funai, Y. Seki, I. Tamai, L. Schakel, K. Sakata, T. Pillaiyar, A. Taguchi, A. Taniguchi, M. Gutschow, C. Muller, K. Takeuchi, M. Hirohama, A. Kawaguchi, M. Kojima, T. Senda, Y. Shirasaka, W. Kamitani, Y. Hayashi
- Organizer
  The 36th European and 12th International Peptide Symposium (EPS/IPS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物の消化管初回通過代謝における膜透過性/代謝活性の相互干渉とその細胞動態解析2022
- Author(s)
  八杉優護、白坂善之、鈴木悟、玉井郁巳
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物の消化管吸収、送達、相互作用および毒性を予測する2022
- Author(s)
  白坂善之
- Organizer
  創剤研究コンソーシアム 2021年度第2回研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] Mechanistic analysis of drug-induced gastrointestinal toxicity considering pharmacokinetic interinfluence between serotonin and gut microbiota dynamics2022
- Author(s)
  Suguru Asaji, Yoshiyuki Shirasaka, Yuta Funai, Yuta Seki, Ikumi Tamai
- Organizer
  第37回日本薬物動態学会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物性消化器毒性解析 (2): 水分調節機能に及ぼす消化管内セロトニン動態の影響2022
- Author(s)
  鮒井悠汰、白坂善之、関裕太、浅地英、大島浩子、大島正伸、玉井郁巳
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物性消化器毒性解析 (1): トランスポーターを介したセロトニン動態変動とその腸内細菌叢への影響2022
- Author(s)
  関裕太、白坂善之、鮒井悠汰、浅地英、玉井郁巳
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] トランスポーターを介したセロトニン動態変動に起因したメトホルミンの消化器毒性発現2022
- Author(s)
  浅地英、白坂善之、鮒井悠汰、関裕太、玉井郁巳
- Organizer
  日本医療薬学会第5回フレッシャーズ・カンファランス
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物動態学の視点から: 代謝酵素/トランスポーターを介した薬物吸収動態とその原薬-製剤間変動2022
- Author(s)
  白坂善之
- Organizer
  第37回日本薬物動態学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物動態/ホルモン/腸内細菌叢の因果解析とオルガノイド技術応用による薬物性消化器毒性予測法の確立2022
- Author(s)
  白坂善之
- Organizer
  日本薬剤学会経口吸収FG/日本薬物動態学会吸収DIS 合同研究討論会2022
- Invited
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物-飲料間相互作用に及ぼす浸透圧およびOATPの影響とその寄与解析2022
- Author(s)
  竹村美由記、白坂善之、稲永上輝、荻さやか、玉井郁巳
- Organizer
  薬物-飲料間相互作用に及ぼす浸透圧およびOATPの影響とその寄与解析
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] Quantitative analysis of the effect of osmolality on beverage-drug interaction by evaluating ingredient absorption2022
- Author(s)
  Miyuki Takemura, Yoshiyuki Shirasaka, Sayaka Ogi, Ikumi Tamai
- Organizer
  GPEN 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] セロトニン動態/腸内細菌叢の因果性に基づく経口医薬品の消化器毒性発現機構解析2022
- Author(s)
  白坂善之
- Organizer
  日本薬学会第142年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] How the postprandial Magenstrasse (gastric water-pathway) is formed? : challenge to reproduce the pathway in the in vitro chamber2022
- Author(s)
  Ryosuke Sakai, Toshihide Takagi, Keiko Minami, Makoto Kataoka, Yoshiyuki Shirasaka, Ikumi Tamai, Shinji Yamashita
- Organizer
  4th International Symposium on BA/BE of Oral Drug Product
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 放出制御製剤の最適化を指向したCYP3A4基質薬物の消化管吸収動態変動解析2022
- Author(s)
  村山枝美果、白坂善之、鈴木悟、Peter Langguth、玉井郁巳
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] メトホルミンの新規作用機序: グルコースの消化管排泄促進メカニズムの解明2022
- Author(s)
  荻さやか、白坂善之、竹村美由記、玉井郁巳
- Organizer
  日本医療薬学会第5回フレッシャーズ・カンファランス
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] シン・薬物吸収動態学：製剤化で変わるCYP3A/P-gpの影響2022
- Author(s)
  白坂善之
- Organizer
  薬物動態談話会2022年9月例会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] Quantitative analysis of the effect of osmolality on beverage-drug interaction by evaluating saccharide absorption2021
- Author(s)
  Miyuki Takemura, Yoshiyuki Shirasaka, Kazuki Inanaga, Sayaka Ogi, Ikumi Tamai
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] Quantitative analysis of the effect of absorption characteristics on CYP3A-mediated intestinal drug-drug interactions using physiologically based pharmacokinetic absorption model2021
- Author(s)
  Satoru Suzuki, Yoshiyuki Shirasaka, Emika Murayama, Ikumi Tamai
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] セロトニン動態/腸内細菌叢の因果解析に基づく薬物性消化器毒性発現機構の定量的解明2021
- Author(s)
  関裕太、白坂善之、鮒井悠汰、浅地英、玉井郁巳
- Organizer
  第15回次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] Mechanistic analysis of drug-induced gastrointestinal toxicity caused by altered disposition of serotonin2021
- Author(s)
  uta Funai, Yoshiyuki Shirasaka, Yuta Seki, Suguru Asaji, Ikumi Tamai
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 消化管内生理環境・機能解析に基づく薬物-飲食物間相互作用予測2021
- Author(s)
  白坂善之
- Organizer
  第42回日本臨床薬理学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] セロトニン動態変動に起因した薬物性消化器毒性の発現機構解析2021
- Author(s)
  鮒井悠汰、白坂善之、関裕太、玉井郁巳
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物の消化管吸収と食事の影響2021
- Author(s)
  白坂善之
- Organizer
  第52回日本消化吸収学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] 薬物動態の視点から: 消化管内生理環境・機能に起因した薬物-飲食物間相互作用とその定量的予測2021
- Author(s)
  白坂善之
- Organizer
  日本薬物動態学会第36回年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07165
[Presentation] CYP3A4基質薬物の消化管代謝に及ぼす膜透過性の影響2018
- Author(s)
  松尾瑞帆、白坂善之、堀内琢矢、田村航輝、小俣智穂、茂木友里、岸本久直、井上勝央
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] 消化管水分動態 (1): 消化管水分調節機構の定量的解析2018
- Author(s)
  一條一貴、白坂善之、鮒井悠汰、鈴木悟、竹村美由記、岸本久直、井上勝央
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] Characteristic and kinetic analysis of gastrointestinal water dynamics affecting oral drug absorption2018
- Author(s)
  Yoshiyuki Shirasaka
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] 薬物の細胞膜透過過程における粘液層構成タンパク質MUC1の影響2018
- Author(s)
  宮崎歌織、岸本久直、大森萌子、白坂善之、井上勝央
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] A Novel Physiologically-based Absorption Model Considering Gastrointestinal Fluid Dynamics2018
- Author(s)
  Satoru Suzuki, Yoshiyuki Shirasaka, Yuta Tateishi, Ren Okada, Hisanao Kishimoto and Katsuhisa Inoue
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] 消化管水分動態解析 (2): 水分吸収/分泌の定量的解析による水分挙動推定2017
- Author(s)
  15)一條一貴、白坂善之、鮒井悠汰、小田理加、岸本久直、井上勝央
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] CYP3A4基質薬物の消化管代謝/吸収性評価システムの構築2017
- Author(s)
  13)堀内琢矢、白坂善之、茂木友里、一條一貴、松尾瑞帆、岸本久直、井上勝央
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] Kinetic Analysis of Gastrointestinal Water Absorption and Secretion to Quantitatively Predict Luminal Water Volume2017
- Author(s)
  8)Yoshiyuki Shirasaka, Kazuki Ichijo, Ren Okada, Marika Ishihara, Yuta Funai, Satoru Suzuki, Rika Oda, Hisanao Kishimoto and Katsuhisa Inoue
- Organizer
  2017 AAPS Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] Quantitative Analysis of Gastrointestinal Water Absorption and Secretion to Estimate Luminal Water Dynamics2017
- Author(s)
  2)Kazuki Ichijo, Yoshiyuki Shirasaka, Marika Ishihara, Yuta Funai, Hisanao Kishimoto, Katsuhisa Inoue
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] Impact of Water Absorption/Secretion on the Intestinal Drug Absorption and Drug-Beverage Interactions2016
- Author(s)
  Yoshiyuki Shirasaka, Rika Oda, Kazuki Ichijo, Ren Okada, Yuta Funai, Satoru Suzuki, Takuya Horiuchi, Yuko Kurokawa, Hisanao Kishimoto and Katsuhisa Inoue
- Organizer
  2016 AAPS Annual Meeting and Exposition
- Place of Presentation
  Colorado Convention Center (USA)
- Year and Date
  2016-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] Quantitative Prediction of the Effect of Controlled-Release Formulation on the Intestinal Absorption of P-Glycoprotein Substrates2016
- Author(s)
  Yoshiyuki Shirasaka, Akari Eguchi, Ren Okada, Satoru Suzuki, Hisanao Kishimoto, Marija Tubic、Peter Langguth and Katsuhisa Inoue
- Organizer
  日本薬物動態学会第31回年会
- Place of Presentation
  キッセイ文化ホール (長野県)
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] 消化管内水分動態に基づく薬物吸収性変動とその定量解析2016
- Author(s)
  小田理加、白坂善之、石原麻梨華、岡田怜、一條一貴、茂木友里、岸本久直、井上勝央
- Organizer
  日本薬剤学会第31年会
- Place of Presentation
  長良川国際会議場 (岐阜県)
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K15165
[Presentation] Impact of CYP3A5 Expression on CYP3A-Mediated Drug-Drug Interactions–Based on Research Abroad for Improving English, Experiencing Other Cultures, Meeting New People, Challenging Myself, and Becoming Global Expert in Pharmaceutics-2013
- Author(s)
  Yoshiyuki Shirasaka
- Organizer
  日本薬剤学会第28年会東西合同グローバルGEセミナーワークショップ.
- Place of Presentation
  ウインクあいち(愛知県産業労働センター)/名古屋
- Year and Date
  2013-05-25
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Interindividual Variability of CYP2C19-Catalyzed Drug Metabolism Due to Differences in the Diplotypes2013
- Author(s)
  Yoshiyuki Shirasaka, Amarjit S. Chaudhry, Timothy Wong, Justina C. Calamia, Nina Isoherranen, Allan E. Rettie, Erin G. Schuetz, and Kenneth E. Thummel
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  The Westin Harbour Castle, Toronto, Ontario, Canada
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Inhibition of CYP2C19 and CYP3A4 by Omeprazole and its Metabolites2013
- Author(s)
  Jennifer E. Sager, Yoshiyuki Shirasaka, Justin D. Lutz, Connie Davis, and Nina Isoherranen
- Organizer
  18th International Conference on Cytochrome P450
- Place of Presentation
  Husky Union Building (HUB), University of Washington, Seattle, WA
- Year and Date
  2013-06-19
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Interindividual Variability of CYP2C19-Catalyzed Drug Metabolism Due to Differences in the Diplotypes2013
- Author(s)
  Yoshiyuki Shirasaka, Amarjit S. Chaudhry, Timothy Wong, Justina C. Calamia, Nina Isoherranen, Allan E. Rettie, Erin G. Schuetz, and Kenneth E. Thummel.
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  The Westin Harbour Castle (Toronto, Canada)
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions2013
- Author(s)
  Yoshiyuki Shirasaka, Jennifer Sager, Justin Lutz, Connie Davis, and Nina Isoherranen
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインクあいち(愛知県産業労働センター)/名古屋
- Year and Date
  2013-05-25
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Substrate-Dependent Drug-Grapefruit Juice Interactions Caused by Multiple Binding Sites on OATP2B12012
- Author(s)
  Takanori Mori, Yoshiyuki Shirasaka, Yukiko Murata, Takeo Nakanishi and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋/千葉
- Year and Date
  2012-11-21
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Impact of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism : Considerations for Modeling CYP3A-Mediated Drug-Drug Interactions2012
- Author(s)
  Yoshiyuki Shirasaka, Chi-Chi Peng, Shu-Ying Chang, Mary F. Grubb, Stephen R. Johnson, A. David Rodrigues, Kenneth E. Thummel, and Nina Isoherranen
- Organizer
  18th North American Regional ISSX Meeting
- Place of Presentation
  Hilton Anatole Dallas Hotel, Dallas, Texas, USA
- Year and Date
  2012-10-15
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Long-Lasting Effect of Fruit Juice on Intestinal Absorptive Transporter OATP2B12012
- Author(s)
  Yukiko Murata, Megumi Shichiri, Takanori Mori, Yoshiyuki Shirasaka, Takeo Nakanishi and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋/千葉
- Year and Date
  2012-11-21
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] A Role of Prostaglandin Transporter in Regulating PGE2 Release from Human Bronchial BEAS-2B Cells under Inflammatory Conditions2012
- Author(s)
  Yoshiyuki Shirasaka, Takeo Nakanishi, Taku Kasai, Megumi Scichiri, Kazuyuki Hayashi, Akio Nishiura, and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋/千葉
- Year and Date
  2012-11-21
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] VARIABILITY OF FRUIT JUICE-DRUG INTERACTION IN ABSORPTION PROCESS CAUSED BY MULTIPLE BINDING SITES ON OATP2B12011
- Author(s)
  Takanori Mori, Yoshiyuki Shirasaka, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島国際会議場（広島県）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] FUNCTIONAL PLEIOTROPY OF OATP2B1 DUE TO MULTIPLE BINDING SITES2011
- Author(s)
  Yoshiyuki Shirasaka, Takanori Mori, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島国際会議場（広島県）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Functional Pleiotropy of OATP2B1 Due to Multiple Binding Sites2011
- Author(s)
  Yoshiyuki Shirasaka, Takanori Mori, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi, and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  広島国際会議場/広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Attenuation of Oral Absorption of P-glycoprotein Substrate Drugs by Administrating in Controlled-Release Formulation2011
- Author(s)
  Yoshiyuki Shirasaka, Takeo Nakanishi, Peter Langguth, and Ikumi Tamai
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  Kobe International Conference Center/Kobe, Japan
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Attenuation of Oral Absorption of P-glycoprotein Substrate Drugs by Administrating in Controlled-Release Formulation2011
- Author(s)
  Yoshiyuki Shirasaka, Takeo Nakanishi, Peter Langguth, and Ikumi Tamai
- Organizer
  International Symposium on BA/BE of Oral Drug Products
- Place of Presentation
  Kobe International Conference Center（兵庫県）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] P-gpを介した薬物吸収動態解析に基づいた徐放性製剤設計の最適化2011
- Author(s)
  白坂善之、Peter Langguth、中西猛夫、玉井郁巳
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀/東京
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] DRUG ABSORPTION AND INTERACTION ON INTESTINAL TRANSPORTERS2011
- Author(s)
  Ikumi Tamai, Yoshiyuki Shirasaka, Takeo Nakanishi
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島国際会議場（広島県）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Influx/Effluxトランスポーターによる薬物の消化管吸収制御2011
- Author(s)
  白坂善之, 中西猛夫, 玉井郁巳
- Organizer
  日本薬学会第131年会
- Place of Presentation
  東日本大震災のため誌上開催
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] シンポジウム「小腸上皮細胞の機能特性を利用した医薬品吸収促進戦略」Influx/Effluxトランスポーターによる薬物の消化管吸収制御機構2011
- Author(s)
  白坂善之、中西猛夫、玉井郁巳
- Organizer
  日本薬学会第131年会
- Place of Presentation
  東日本大震災のため誌上開催
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21659038
[Presentation] P-gpを介した薬物吸収動態解析に基づいた徐放性製剤設計の最適化2011
- Author(s)
  白坂善之、Peter Langguth、中西猛夫、玉井郁巳
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀（東京都）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Influx/Effluxトランスポーターによる薬物の消化管吸収制御2011
- Author(s)
  白坂善之
- Organizer
  日本薬学会第131年会
- Place of Presentation
  (東日本大震災のため誌上開催)
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] OATP/P-gp基質薬物の消化管吸収動態解析に基づく徐放性製剤設計の最適化2011
- Author(s)
  白坂善之
- Organizer
  日本薬剤学会経口吸収フォーカスグループ第2回合宿討論会
- Place of Presentation
  KKR京都「くに荘」/京都
- Year and Date
  2011-09-05
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Differential Interaction of Fruit Juices with Transporter-Mediated Absorption of Drugs2011
- Author(s)
  Megumi Shichiri, Yoshiyuki Shirasaka, Takanori Mori, Takeo Nakanishi, and Ikumi Tamai
- Organizer
  The 4th Asian Pacific ISSX Regional Meeting
- Place of Presentation
  Tainan, Taiwan
- Year and Date
  2011-04-24
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] OATP/P-gp 基質薬物の消化管吸収動態解析に基づく徐放性製剤設計の最適化2011
- Author(s)
  白坂善之
- Organizer
  第２回経口吸収FG合宿検討会
- Place of Presentation
  KKR京都「くに荘」（京都府）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Drug Absorption and Interaction on Intestinal Transporters2011
- Author(s)
  Ikumi Tamai, Yoshiyuki Shirasaka, and Takeo Nakanishi
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  広島国際会議場/広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Variability of Fruit Juice-Drug Interaction in Absorption Process Caused by Multiple Binding Sites on OATP2B12011
- Author(s)
  Takanori Mori, Yoshiyuki Shirasaka, Megumi Shichiri, Satoshi Koyama, Yukiko Murata, Yusuke Hoshino, Takeo Nakanishi, and Ikumi Tamai
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  広島国際会議場/広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] ヒト癌細胞株におけるOAT2を介した光線力学療法薬5-アミノレブリン酸の細胞膜輸送2010
- Author(s)
  小川哲郎、中西猛夫、白坂善之、松井裕史、玉井郁巳
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島県強度文化会館(徳島市、徳島)
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-21890084
[Presentation] COPD治療薬の体内動態におけるトランスポーターの役割2010
- Author(s)
  中西猛夫、春田恒満、長谷川佳駿、白坂善之、玉井郁己
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山国際会議場(富山県)
- Year and Date
  2010-11-29
- Data Source
  KAKENHI-PROJECT-21659038
[Presentation] Differential Interaction of Grapefruit Juice with Intestinal Absorption of HMG-CoA Reductase Inhibitors Pravastatin and Pitavastatin2010
- Author(s)
  Y.Shirasaka.K.Suzuki, T.Nakanishi.I.Tamai
- Organizer
  Globalization of Pharmaceutics Education Network (GPEN) Meeting
- Place of Presentation
  University of North Carolina(米国)
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-21659038
[Presentation] 消化管吸収過程における薬物とミルクのペプチドトランスポーター(PEPT 1)を介した相互作用の解析2010
- Author(s)
  小林彰子、我妻瑤恵、森本かおり、叶隆、和田翔、白坂善之、玉井郁巳、荻原琢男
- Organizer
  第25回日本薬剤学会年会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館(徳島県)
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-21659038
[Presentation] Differential Interaction of Grapefruit Juice with Intestinal Absorption of HMG-CoA Reduetase Inhibitors Pravastatin and Pitavastatin2010
- Author(s)
  Yoshiyuki Shirasaka
- Organizer
  GPEN 2010 (Globatization of Pharmaceutics Eduction Network)
- Place of Presentation
  University of North Carolina, Chapel Hill, NC, USA
- Year and Date
  2010-10-12
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] DIFFFRENTIAL lNTERACTI0N OF FRUIT JUICES ON TRANSPORTIER-MLDIATED ABSORPTION OF DRUGS2010
- Author(s)
  Megumi Shichiri, Yoshiyuki Shirasaka, Takanori Mori, Takeo Nakanishi, Ikumi Tainai
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21659038
[Presentation] トランスポーターを介したHMG-CoA還元酵素阻害薬の消化管吸収動態2010
- Author(s)
  白坂善之, 鈴木健介, 中西猛夫, 玉井郁巳
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館(徳島
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] DIFFERENTIAL TRANSPORTER-MEDIATED INTBRACTION OF FRUITJUICE WITH INTESTINAL ABSORPTION OF PRAVASTATIN ANDPITAVASTATIN IN RATS2010
- Author(s)
  Yoshiyuki Shirasaka, Kensuke Suzuki, Takeo Nakanishi, Ikumi Tamai
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21659038
[Presentation] Differential Transporter-Mediated Interaction of fruit juice with pravastatin and pitavastatin in rats.2010
- Author(s)
  Yoshiyuki Shirasaka, Kensuke Suzuki, Takeo Nakanishi, Ikumi Tamai.
- Organizer
  第24回日本薬物動態学会年会
- Place of Presentation
  大宮ソニックシティ(埼玉)
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] ヒト癌細胞株におけるOAT2を介した光線力学療法薬5・アミノレブリン酸の細胞膜輸送2010
- Author(s)
  小川哲朗、中西猛夫、白坂善之、長崎幸夫、松井裕史、玉井郁己
- Organizer
  第25回日本薬剤学会年会
- Place of Presentation
  あわぎんホール徳勧県郷土文化会館(徳島県)
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-21659038
[Presentation] Uric Acid Transporter-Mediated Uricosuric Effect of RDEA594, A Metab olite of Antiviral Agent RDEA8062010
- Author(s)
  Mayuko Yoshifuji, Masanobu Sato, Li-Tain Yeh, Kohei Ohya, Yoshiyuki Shirasaka, Takeo Nakanishi, Ikumi Tamai
- Organizer
  Globalization of Pharmaceutics Education Network (GPEN) Meeting
- Place of Presentation
  University of North Carolina,チャペルヒル,NC,米国
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-21390044
[Presentation] Differential Interaction of Grapefruit Juice with Intestinal Absorption of HMG-CoA Reductase Inhibitors Pravastatin and Pitavastatin.2010
- Author(s)
  Yoshiyuki Shirasaka, Kensuke Suzuki, Takeo Nakanishi, Ikumi Tamai.
- Organizer
  GPEN 2010 (Globalization of Pharmaceutics Education Network
- Place of Presentation
  University of North Carolina, Chapel Hill, NC (USA)
- Year and Date
  2010-10-12
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] トランスポーターを介したHMG・CoA還元酵索阻害薬の消化IS吸収動態2010
- Author(s)
  白坂善之、鈴木健介、中西猛夫、玉井郁己
- Organizer
  第25回日本薬剤学会年会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館(徳島県)
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-21659038
[Presentation] quantitative Visualization for Bile Canalicular transporter function using Sandwich・?culatured rat hepatocytes2010
- Author(s)
  Yoko Fukuyama, Takeo Nakanishi, Miho Ikenaga, Yoshiyuki Shirasaka, Ikumi Tamai
- Organizer
  第25回日本薬物動態学会年会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21659038
[Presentation] イプラトロピウムの気道吸収における有機カチオン/カルニチントランスポーターの関与2010
- Author(s)
  春田恒満、中西猛夫、長谷川佳駿、白坂善之、玉井郁巳
- Organizer
  日本薬学会北陸支部第122回例会
- Place of Presentation
  北陸大学(石川県)
- Year and Date
  2010-11-21
- Data Source
  KAKENHI-PROJECT-21659038
[Presentation] Differential Transporter-Mediated Interaction of fruit juice with pravastatin and pitavastatin in rats2010
- Author(s)
  Yoshiyuki Shirasaka
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ(埼玉県)
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] トランスポーターを介したHMG-CoA還元酵素阻害薬の消化管吸収動態2010
- Author(s)
  白坂善之
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんボール徳島県郷土文化会館(徳島県)
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] トランスポーターに起因した薬物の消化管吸収部位差に関する研究2009
- Author(s)
  白坂善之, 松下高志, 中西猛夫,Peter Langguth, 玉井郁巳
- Organizer
  第24回日本薬物動態学会年会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] 薬物の消化管吸収に及ぼすP糖蛋白質の影響とその評価に関する研究2009
- Author(s)
  白坂善之
- Organizer
  日本薬剤学会第34回製剤セミナー
- Place of Presentation
  浜名湖ロイヤルホテル(静岡)
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] OATP/P-gpを介した薬物の消化管吸収動態とその種差2009
- Author(s)
  白坂善之, 蔵岡えりか, 中西猛夫,Peter Langguth, 玉井郁巳
- Organizer
  日本薬剤学会第24年会
- Place of Presentation
  静岡県コンベンションアーツセンター(静岡)
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] A Molecular Mechanism of Hepatic Uptake of γ-Butyrobetaine, a Precursor of Carnitine Biosynthesis2009
- Author(s)
  Fujita M., Nakanishi T., Shibue Y., Fukuyama Y., Shirasaka Y., Tamai I.
- Organizer
  生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪大学(大阪)
- Data Source
  KAKENHI-PROJECT-21659038
[Presentation] OATP-Mediated Intestinal Absorption of HMG-CoA Reductase Inhibitors in Rats2009
- Author(s)
  Kensuke Suzuki, Yoshiyuki Shirasaka, Takeo Nakanishi, Ikumi Tamai
- Organizer
  The 3^<rd> Asian Pacific ISSX Regional Meeting 2009
- Place of Presentation
  The Imperial Queen's Park Hotel (Thailand)
- Year and Date
  2009-05-11
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] トランスポーターに起因した薬物の消化管吸収部位差に関する研究2009
- Author(s)
  白坂善之
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2009-11-28
- Data Source
  KAKENHI-PROJECT-21790147
[Presentation] Sandwich cultureを評価系として用いた肝トランスポーター活性可視化に関する研究2008
- Author(s)
  吉田憲司、中村利通、白坂善之、玉井郁巳
- Organizer
  第128回日本薬学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19390046
[Presentation] Counteracting Interplay of P-Glycoprotein and OATP I Intestinal Absorption of β-Blocker Talinolol2008
- Author(s)
  Yoshiyuki Shirasaka
- Organizer
  2^<ND> Asian Pacific Regional ISSX Meeting
- Place of Presentation
  Shanghai, China
- Year and Date
  2008-05-13
- Data Source
  KAKENHI-PROJECT-20890082
[Presentation] Influx/Effluxトランスポーターの優位性に基づいた薬物の消化管吸収解析2008
- Author(s)
  白坂善之
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌
- Year and Date
  2008-05-21
- Data Source
  KAKENHI-PROJECT-20890082
[Presentation] ROLE OF ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A4 IN HEPATIC UPTAKE OF NAFCILLIN IN RATS.2008
- Author(s)
  Yasushi Morohashi, Taiki Shimada, Yuta Shibue, Yoshiyuki Shirasaka, Yukio Kato, Ikumi Tamai
- Organizer
  日本薬物動態学会
- Place of Presentation
  熊本市
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19390046
[Presentation] ROLE OF ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A4 IN HEPATIC UPTAKE OF NAFCILLIN IN RATS2008
- Author(s)
  Yasushi Morohashi, Taiki Shimada, Yuta Shibue, Yoshiyuki Shirasaka, Yukio Kato, Ikumi Tamai
- Organizer
  日本薬物動態学会
- Place of Presentation
  熊本
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19390046
[Presentation] OATP-MEDIATED ABSORPTION OF TALINOLI IS RESPONS IBLE FOR THE REDUCED BIOILAILABILHY BY FRUIT JUICE2008
- Author(s)
  Yoshiyuki Shirasaka
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-20890082
[Presentation] Sandwich culture を評価系として用いた肝トランスポーター活性可視化に関する研究2008
- Author(s)
  吉田憲司、中村利通、白坂善之、玉井郁巳
- Organizer
  第128 回日本薬学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19390046
[Presentation] Comparison of Hepatic Uptake of Beta-Lactam Antibiotics Mediated by OATP Transporters between Rat and Human2007
- Author(s)
  Masanori Irokawa, Taiki Shimada, Masanori Nakakariya, Yoshiyuki Shirasaka and Ikumi Tamai
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19390046
[Presentation] Comparison of Hepatic Uptake of Beta-Lactam Antibiotics Mediated by OATP Transporters between Rat and Human2007
- Author(s)
  Masanori Irokawa, Taiki Shimada, Masanori Nakakariya, Yoshiyuki Shirasaka,and Ikumi Tamai
- Organizer
  第29 回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-11-27
- Data Source
  KAKENHI-PROJECT-19390046
[Presentation] Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions
- Author(s)
  Yoshiyuki Shirasaka, Jennifer Sager, Justin Lutz, Connie Davis, and Nina Isoherranen.
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインクあいち/愛知県産業労働センター (名古屋)
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Substrate-Dependent Drug-Grapefruit Juice Interactions Caused by Multiple Binding Sites on OATP2B1
- Author(s)
  Takanori Mori, Yoshiyuki Shirasaka, Yukiko Murata, Takeo Nakanishi and Ikumi Tamai.
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋（東京都）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Inhibition of CYP2C19 and CYP3A4 by Omeprazole and its Metabolites
- Author(s)
  Jennifer E. Sager, Yoshiyuki Shirasaka, Justin D. Lutz, Connie Davis, and Nina Isoherranen.
- Organizer
  18th International Conference on Cytochrome P450
- Place of Presentation
  Husky Union Building (HUB), University of Washington (Seattle, USA)
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] A Role of Prostaglandin Transporter in Regulating PGE2 Release from Human Bronchial BEAS-2B Cells under Inflammatory Conditions
- Author(s)
  Yoshiyuki Shirasaka, Takeo Nakanishi, Taku Kasai, Megumi Scichiri, Kazuyuki Hayashi, Akio Nishiura, and Ikumi Tamai.
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋（東京都）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Long-Lasting Effect of Fruit Juice on Intestinal Absorptive Transporter OATP2B1
- Author(s)
  Yukiko Murata, Megumi Shichiri, Takanori Mori, Yoshiyuki Shirasaka, Takeo Nakanishi and Ikumi Tamai.
- Organizer
  第26回日本薬物動態学会年会
- Place of Presentation
  タワーホール船橋（東京都）
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Impact of CYP3A5 Expression on CYP3A-Mediated Drug-Drug Interactions –Based on Research Abroad for Improving English, Experiencing Other Cultures, Meeting New People, Challenging Myself, and Becoming Global Expert in Pharmaceutics-
- Author(s)
  Yoshiyuki Shirasaka
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインクあいち/愛知県産業労働センター (名古屋)
- Invited
- Data Source
  KAKENHI-PROJECT-23590175
[Presentation] Impact of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Considerations for Modeling CYP3A-Mediated Drug-Drug Interactions
- Author(s)
  Yoshiyuki Shirasaka, Chi-Chi Peng, Shu-Ying Chang, Mary F. Grubb, Stephen R. Johnson, A. David Rodrigues, Kenneth E. Thummel, and Nina Isoherranen.
- Organizer
  18th North American Regional ISSX Meeting
- Place of Presentation
  Hilton Anatole Dallas Hotel (USA)
- Data Source
  KAKENHI-PROJECT-23590175

1. TAMAI Ikumi (20155237)

# of Collaborated Projects: 7 results

# of Collaborated Products: 118 results
2. NAKANISHI Takeo (30541742)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
3. 湯川博 (30634646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 荒川大 (40709028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 中島美紀 (70266162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. INOUE Katsuhisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
7. KISHIMOTO Hisanao

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
8. KAWAGUCHI Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shirasaka Yoshiyuki 白坂 善之

SHIRASAKA Yoshiyuki 白坂 善之

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Establishment of predictive approach of oral drug absorption based on gastrointestinal imaging analysis using quantum dot and tissue clearing technologiesPrincipal Investigator

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尿酸結合タンパク質CD38を介した尿酸による炎症応答調節

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Quantitative Prediction of Oral Drug Absorption by Kinetically Analyzing Gastrointestinal Water DynamicsPrincipal Investigator

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Evaluation of Oral Drug Absorption by Developing In Vitro Culture System for Intestinal Villus CellsPrincipal Investigator

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Regional Difference in the Effect of Influx/Efflux Transporters and Metabolic Enzymes on Intestinal Drug AbsorptionPrincipal Investigator

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Clarification and evaluation of regulation mechanism of uric acid

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細胞内オルガネラ膜トランスポーター活性の定量的可視化による薬物の細胞毒性評価

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Quantitative Evaluation of the Effect of Influx/Efflux Transporters on Oral Drug AbsorptionPrincipal Investigator

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Evaluation of molecular mechanisms of tumor-specific protoporphyr in accumulation induced by 5-aminolevulinic acid

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吸収/排泄型トランスポーターの優位性に基づいた消化管吸収性評価システムの構築Principal Investigator

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Species difference in hepatic disposition of organic anions

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[Journal Article] Functional identification of soluble uric acid as an endogenous inhibitor of CD382024

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[Journal Article] Magnitude of Fruit Juice–Drug Interactions Due to Osmolality-Dependent Fluid Secretion: Differences among Apple, Orange, and Grapefruit Juices2024

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Shirasaka Yoshiyuki 白坂善之

SHIRASAKA Yoshiyuki 白坂善之