Kobayashi Takuya 小林琢也

… Alternative Names

KOBAYASHI Takuya 小林琢也

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Researcher Number	60468585
Affiliation (Current)	2025: 順天堂大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 順天堂大学, 医学部, 助教 2018 – 2020: 順天堂大学, 医学部, 特任研究員 2016 – 2017: 東京大学, 大学院総合文化研究科, 特任研究員 2014: 東京大学, 大学院総合文化研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 59020:Sports sciences-related Except Principal Investigator Basic Section 48020:Physiology-related / Transformative Research Areas, Section (II) / Basic Section 43020:Structural biochemistry-related / Constructive Systems Biology / Biophysics/Chemical physics
Keywords	Principal Investigator イメージング / 粘弾性 / 微小管 / 骨格筋 / 筋挫傷 / 筋収縮 / 衝撃耐性 Except Principal Investigator 構造解析 / カルシウムチャネル / リアノジン受容体 … More / クライオ電子顕微鏡 / イオンチャネル / カルシウムイオン / 筋小胞体 / 骨格筋 / 興奮収縮連関 / 筋肉 / カルシウム遊離チャネル / 筋収縮 / MDシミュレーション / 熱散逸 / 膜蛋白質 / 機能解析 / 創薬 / 悪性高熱症 / サブタイプ / 小胞体 / メカノセンサー / 力センサー / FRET / ミオシンミニフィラメント / ダイニン / 細胞骨格 / 光ピンセット法 / FRET力センサー / FRET張力センサー / ミオシン / キネシン / アクチンフィラメント / 微小管 / 生物物理 / in vivoイメージング / サルコメア Less

骨格筋のしなやかさにおける微小管の役割Principal Investigator
- Principal Investigator
  
  小林琢也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Juntendo University
Heterogeneous thermal signaling in a muscle cell
- Principal Investigator
  
  鈴木団
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Osaka University
Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution system
- Principal Investigator
  
  村山尚
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Juntendo University
Structural analysis of the gating mechanism of cardiac ryanodine receptor
- Principal Investigator
  
  小川治夫
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Kyoto University
Role of Microtubules in the Muscle Structure-Contraction RelationshipPrincipal Investigator
- Principal Investigator
  
  Kobayashi Takuya
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Juntendo University
Molecular basis of subtype-specific channel regulation using novel ryanodine receptor modulators
- Principal Investigator
  
  Murayama Takashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Juntendo University
A study of a mechano-network system based on microtubules by a constructive approach
- Principal Investigator
  
  Yajima Junichiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Constructive Systems Biology
- Research Institution
  The University of Tokyo
Nano scale in vivo imaging of contractile proteins in mouse skeletal muscle
- Principal Investigator
  
  KAYA Motoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics/Chemical physics
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.2023
- Author(s)
  Gao J, Makiyama T, Yamamoto Y, Kobayashi T, Aoki H, Maurissen TL, Wuriyanghai Y, Kashiwa A, Imamura T, Aizawa T, Huang H, Kohjitani H, Nishikawa M, Chonabayashi K, Fukuyama M, Manabe H, Nakau K, Wada T, Kato K, Toyoda F, Yoshida Y, Makita N, Woltjen K, Ohno S, Kurebayashi N, Murayama T, Sakurai T, Horie M, Kimura T.
- Journal Title
  
  Circulation: Arrhythmia and Electrophysiology
  
  Volume: 16 Issue: 3 Pages: 9999-9999
- DOI
  10.1161/circep.122.011387
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11368, KAKENHI-PROJECT-21K06781, KAKENHI-PROJECT-22K08179, KAKENHI-PROJECT-20K17113, KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-21H02920
[Journal Article] Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations2022
- Author(s)
  Kobayashi Takuya、Tsutsumi Akihisa、Kurebayashi Nagomi、Saito Kei、Kodama Masami、Sakurai Takashi、Kikkawa Masahide、Murayama Takashi、Ogawa Haruo
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 2821-2821
- DOI
  10.1038/s41467-022-30429-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-21H02411, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-23K24067
[Journal Article] Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR22022
- Author(s)
  Kurebayashi Nagomi、Murayama Takashi、Ota Ryosaku、Suzuki Junji、Kanemaru Kazunori、Kobayashi Takuya、Ohno Seiko、Horie Minoru、Iino Masamitsu、Yamashita Fumiyoshi、Sakurai Takashi
- Journal Title
  
  Journal of General Physiology
  
  Volume: 154 Issue: 9
- DOI
  10.1085/jgp.202112869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-20H03423, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-23K24067
[Journal Article] Therapeutic effects of novel type1 ryanodine receptor inhibitor on skeletal muscle diseases2022
- Author(s)
  Yamazawa Toshiko、Kobayashi Takuya、Kurebayashi Nagomi、Murayama Takashi
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 157 Issue: 1 Pages: 15-22
- DOI
  10.1254/fpj.21068
- NAID
  130008138777
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K11368
[Journal Article] A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery2022
- Author(s)
  Murayama Takashi、Kurebayashi Nagomi、Numaga-Tomita Takuro、Kobayashi Takuya、Okazaki Satoru、Yamashiro Kyosuke、Nakada Tsutomu、Mori Shuichi、Ishida Ryosuke、Kagechika Hiroyuki、Yamada Mitsuhiko、Sakurai Takashi
- Journal Title
  
  Journal of General Physiology
  
  Volume: 154 Issue: 12
- DOI
  10.1085/jgp.202213230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-22K06828, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-23K24067
[Journal Article] Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation2021
- Author(s)
  Itoh Hideki、Murayama Takashi、Kurebayashi Nagomi、Ohno Seiko、Kobayashi Takuya、Fujii Yusuke、Watanabe Masaya、Ogawa Haruo、Anzai Toshihisa、Horie Minoru
- Journal Title
  
  Journal of Electrocardiology
  
  Volume: 69 Pages: 111-118
- DOI
  10.1016/j.jelectrocard.2021.09.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-20K08473, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-21H02411
[Journal Article] The Ryanodine Receptor as a Sensor for Intracellular Environments in Muscles2021
- Author(s)
  Kobayashi Takuya、Kurebayashi Nagomi、Murayama Takashi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 19 Pages: 10795-10795
- DOI
  10.3390/ijms221910795
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11368, KAKENHI-PROJECT-19H03404
[Journal Article] A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke2021
- Author(s)
  Yamazawa Toshiko、Kobayashi Takuya、Kurebayashi Nagomi、Konishi Masato、Noguchi Satoru、Inoue Takayoshi、Inoue Yukiko U.、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4293-4293
- DOI
  10.1038/s41467-021-24644-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H04922, KAKENHI-PROJECT-19H03198, KAKENHI-PROJECT-19K06955, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07306, KAKENHI-PROJECT-20K06467, KAKENHI-PROJECT-20K11368, KAKENHI-PROJECT-21K19752, KAKENHI-PROJECT-19H03404
[Journal Article] The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity2021
- Author(s)
  Hana Inoue, Takashi Murayama, Takuya Kobayashi, Masato Konishi, and Utako Yokoyama
- Journal Title
  
  Journal of General Physiology
  
  Volume: 153 Issue: 6
- DOI
  10.1085/jgp.202012708
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09112, KAKENHI-PROJECT-19H03404
[Journal Article] Conformational diversity of dynactin sidearm and domain organization of its subunit p150.2020
- Author(s)
  Kei Saito, Takashi Murayama, Tomone Hata, Takuya Kobayashi, Keitaro Shibata, Saiko Kazuno, Tsutomu Fujimura, Takashi Sakurai, and Yoko Y. Toyoshima
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: - Issue: 12 Pages: 1218-1231
- DOI
  10.1091/mbc.e20-01-0031
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19J13870, KAKENHI-PROJECT-17K00874, KAKENHI-PROJECT-20K05880, KAKENHI-PROJECT-19H03190, KAKENHI-PROJECT-19H03404
[Presentation] 計算機実験によるRyR1阻害薬結合構造の予測2023
- Author(s)
  八木珠麗菜,藤井咲衣,櫻井隆,村山尚,小林琢也
- Organizer
  第９７回日本薬理学会年会
- Data Source
  KAKENHI-PLANNED-22H05053
[Presentation] 骨格筋の粘弾性における微小管の役割2023
- Author(s)
  小林琢也, 茅元司,呉林なごみ, 村山尚, 櫻井隆
- Organizer
  第６１回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-20K11368
[Presentation] 骨格筋のしなやかさ～粘弾性に寄与する微小管～2023
- Author(s)
  小林琢也
- Organizer
  第４６回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K10692
[Presentation] 骨格筋のしなやかさ～粘弾性に寄与する微小管～2023
- Author(s)
  小林琢也
- Organizer
  第４６回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K11368
[Presentation] The effects of microtubule depolymerization on muscular viscoelastic properties.2023
- Author(s)
  T Kobayashi, N Kurebayashi, Murayama, T Sakurai, M Kaya
- Organizer
  The 5th Rocky Mountain Muscle Symposium.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K10692
[Presentation] 計算機実験と生化学実験の統合に基づくscreeningプラットフォームの構築2023
- Author(s)
  藤井咲衣,八木珠麗菜,櫻井隆,村山尚,小林琢也
- Organizer
  第９７回日本薬理学会年会
- Data Source
  KAKENHI-PLANNED-22H05053
[Presentation] 骨格筋の粘弾性における微小管の役割2023
- Author(s)
  小林琢也, 茅元司,呉林なごみ, 村山尚, 櫻井隆
- Organizer
  第６１回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-23K10692
[Presentation] The effects of microtubule depolymerization on muscular viscoelastic properties.2023
- Author(s)
  T Kobayashi, N Kurebayashi, Murayama, T Sakurai, M Kaya
- Organizer
  The 5th Rocky Mountain Muscle Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11368
[Presentation] 微小管脱重合薬により骨格筋の粘弾性は変化する2022
- Author(s)
  小林琢也, 村山尚, 呉林なごみ
- Organizer
  第６０回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-20K11368
[Presentation] 発熱する骨格筋、イオンチャネルの暴走2022
- Author(s)
  小林琢也
- Organizer
  第１１回分子モーター討論会
- Data Source
  KAKENHI-PROJECT-20K11368
[Presentation] 骨格筋疾患治療薬開発のための脱分極誘発性Ca2+遊離再構成プラットフォームの構築2022
- Author(s)
  村山尚、呉林なごみ、冨田（沼賀）拓郎、小林琢也、中田勉、石田良典、森修一、影近弘之、山田充彦、櫻井隆．
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-23K24067
[Presentation] 骨格筋脱分極誘発性Ca2+遊離（DICR）再構成系の開発2022
- Author(s)
  村山尚、呉林なごみ、冨田（沼賀）拓郎、小林琢也、中田勉、山田充彦、櫻井隆
- Organizer
  第8回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03404
[Presentation] 骨格筋脱分極誘発性Ca2+遊離（DICR）再構成系の開発2022
- Author(s)
  村山尚、呉林なごみ、冨田（沼賀）拓郎、小林琢也、中田勉、山田充彦、櫻井隆
- Organizer
  第8回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24067
[Presentation] 骨格筋疾患治療薬開発のための脱分極誘発性Ca2+遊離再構成プラットフォームの構築2022
- Author(s)
  村山尚、呉林なごみ、冨田（沼賀）拓郎、小林琢也、中田勉、石田良典、森修一、影近弘之、山田充彦、櫻井隆
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19H03404
[Presentation] クライオ電子顕微鏡による心筋型リアノジン受容体loss-of-function変異体の解析2021
- Author(s)
  小川治夫、小林琢也、包明久、呉林なごみ、斎藤慧、児玉昌美、櫻井隆、吉川雅英、村山尚
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-21H02411
[Presentation] 新規1型リアノジン受容体（RyR1）阻害剤の結合部位の同定．2021
- Author(s)
  村山尚、呉林なごみ、小林琢也、小川治夫、児玉昌美、森修一、影近弘之、櫻井隆．
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19H03404
[Presentation] 骨格筋脱分極誘発性Ca2+遊離（DICR）再構成系を用いた筋疾患へのアプローチ2021
- Author(s)
  村山尚、呉林なごみ、小林琢也、岡﨑諭、山代暁介、櫻井隆
- Organizer
  第7回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03404
[Presentation] 新規1型リアノジン受容体（RyR1）阻害薬の結合部位の探索．2020
- Author(s)
  村山尚、呉林なごみ、小林琢也、小川治夫、児玉昌美、森修一、影近弘之、櫻井隆．
- Organizer
  第143回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-19H03404
[Presentation] Characterization of novel RyR1-selective inhibitors identified by high-throughput screening using ER Ca2+ measurement.2020
- Author(s)
  Matsukawa H, Murayama T, Kobayashi T, Kurebayashi N, Yamazawa T, Ishigami-Yuasa M, Mori S, Kagechika H, Sakurai T.
- Organizer
  Biophysical Society 64th Annual Meeting
- Data Source
  KAKENHI-PROJECT-19H03404
[Presentation] Therapeutic effects of a novel RyR1 inhibitor on malignant hyperthermia model mice.2020
- Author(s)
  Murayama T, Yamazawa T, Kobayashi T, Kurebayashi N, Noguchi S, Nishino N, Mori S, Kagechika H, Lopez JR, Allen PD, Sakurai T.
- Organizer
  Biophysical Society 64th Annual Meeting
- Data Source
  KAKENHI-PROJECT-19H03404
[Presentation] 新規RyR1抑制薬の悪性高熱症モデルマウスに対する効果．2020
- Author(s)
  村山尚，山澤徳志子，小林琢也，呉林なごみ，野口悟，西野一三，森修一，影近弘之，Jose R. Lopez，Paul D. Allen，櫻井隆．
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19H03404
[Presentation] 小胞体内Ca2+濃度測定により新たに同定されたRyR1選択的阻害剤の性質の検討．2020
- Author(s)
  松川紘之、村山尚、小林琢也、呉林なごみ、山澤徳志子、湯浅磨里、森修一、影近弘之、櫻井隆．
- Organizer
  第6回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03404
[Presentation] 悪性高熱症モデルマウスを用いた新規RyR1阻害薬の治療効果の検討．2019
- Author(s)
  村山尚、山澤徳志子、小林琢也、呉林なごみ、野口悟、井上高良、井上由紀子、森修一、飯沼大翔、間中紀暁、湯浅磨里、影近弘之、西野一三、櫻井隆．
- Organizer
  第5回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03404
[Presentation] Myosin minifilament-driven fragmentation of actin filaments triggers contraction of a disordered actin network2018
- Author(s)
  松田恭平、小林琢也、須河光弘、小礒由里加、豊島陽子、矢島潤一郎
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-16KT0065
[Presentation] The Fragmentation of Actin Filaments Induces the Contraction of the Active Network2017
- Author(s)
  松田恭平、小林琢也、須河光弘、豊島陽子、矢島潤一郎
- Organizer
  第５５回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-16KT0065
[Presentation] The Fragmentation of F-actin induces the contraction of the active network2017
- Author(s)
  Kyohei Matsuda, Takuya Kobayashi, Mitsuhiro Sugawa, Yoko Y Toyoshima, Junichiro Yajima
- Organizer
  ASCB/EMBO 2017 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0065
[Presentation] Autonomous structure formation and contraction of actomyosin regulated by contractile ring related cross-linking proteins (CRCPs).2017
- Author(s)
  松田恭平、小林琢也、須河光弘、豊島陽子、矢島潤一郎
- Organizer
  第61回米国生物物理学会
- Place of Presentation
  ニューオリンズ（米国）
- Year and Date
  2017-02-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0065
[Presentation] Actomyosin contraction with a contractile ring related cross-linker in ann vitro active gel model system2016
- Author(s)
  松田恭平、小林琢也、須河光弘、豊島陽子、矢島潤一郎
- Organizer
  第54回日本生物物理学会大会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16KT0065

1. 呉林なごみ (50133335)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. KAYA Motoshi (00422098)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. Murayama Takashi (10230012)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
4. 小川治夫 (40292726)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. 冨田拓郎 (60705060)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. Yajima Junichiro (00453499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 道上達男 (10282724)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 須河光弘 (80626383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. 渡邊大輝 (30823281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 井上華 (20390700)

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11. 児玉昌美 (30512248)

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12. 鈴木団 (40350475)

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13. 栗崎以久男 (50583340)

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14. 杉原匡美 (80648163)

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15. INOUE Yukiko

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16. 国広なごみ

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# of Collaborated Products: 24 results
17. 石田良典

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Kobayashi Takuya 小林 琢也

KOBAYASHI Takuya 小林 琢也

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骨格筋のしなやかさにおける微小管の役割Principal Investigator

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Heterogeneous thermal signaling in a muscle cell

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Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution system

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Structural analysis of the gating mechanism of cardiac ryanodine receptor

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Role of Microtubules in the Muscle Structure-Contraction RelationshipPrincipal Investigator

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Molecular basis of subtype-specific channel regulation using novel ryanodine receptor modulators

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A study of a mechano-network system based on microtubules by a constructive approach

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Nano scale in vivo imaging of contractile proteins in mouse skeletal muscle

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[Journal Article] Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.2023

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[Journal Article] Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations2022

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[Journal Article] Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR22022

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[Journal Article] Therapeutic effects of novel type1 ryanodine receptor inhibitor on skeletal muscle diseases2022

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[Journal Article] A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery2022

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Kobayashi Takuya 小林琢也

KOBAYASHI Takuya 小林琢也