Akagi Jyunichi 赤木純一

… Alternative Names

Akagi Jun-ichi 赤木純一

AKAGI Jun-ichi 赤木純一

Less

Researcher Number	60512556
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 病理部, 主任研究官
Affiliation (based on the past Project Information) *help	2024: 国立医薬品食品衛生研究所, 病理部, 主任研究官 2017 – 2021: 国立医薬品食品衛生研究所, 病理部, 主任研究官 2016: 国立医薬品食品衛生研究所, 病理部, 研究員 2011 – 2014: 国立医薬品食品衛生研究所, 病理部, 研究員 2010: 国立医薬品食品衛生研究所, 薬理部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Risk sciences of radiation and chemicals / Genetics/Chromosome dynamics / Risk sciences of radiation/Chemicals Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator 損傷乗り越えDNA合成 / グリシドアミド / アクリルアミド / 遺伝毒性 / 突然変異 / 損傷乗り越え複製 / 食品汚染物質 / DNA損傷 / DNA修復 / 変異原性 … More / 人体有害物質 / グリシドアミド付加体 / Polκ / Polι / Polη / DNA損傷トレランス / 遺伝毒性試験法 / 遺伝毒性試験 / DNAポリメラーゼ・ゼータ / 6-4光産物 / 損傷乗り越えDNA複製 / 癌 / 紫外線 / ミスマッチ修復 / DNA複製・修復 … More Except Principal Investigator 紫外線感受性 / DNAポリメラーゼ・イータ / DNA損傷トレランス / (6-4)光産物 / ノックアウトマウス / REV1 / DNAポリメラーゼκ / TLSポリメラーゼ / 損傷トレランス / 突然変異 / DNAポリメラーゼ / 紫外線 / 損傷乗り越え複製 / 遺伝子ノックアウト Less

Analysis of mutagenicity of stable deoxyadenosine adducts produced by exposure to acrylamidePrincipal Investigator
- Principal Investigator
  
  赤木純一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  National Institute of Health Sciences
Molecular mechanism of acrylamide-induced mutagenesis via translesion synthesisPrincipal Investigator
- Principal Investigator
  
  Akagi Jun-ichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  National Institute of Health Sciences
Analysis of the molecular mechanisms of acrylamide-induced mutagenesis by using intracellular translesion synthesis assayPrincipal Investigator
- Principal Investigator
  
  Akagi Jun-ichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  National Institute of Health Sciences
Study of a fast, convenient and sensitive genotoxicity test utilizing cells lacking DNA damage response factorsPrincipal Investigator
- Principal Investigator
  
  AKAGI Jun-ichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  National Institute of Health Sciences
Analyses of functional roles of TLS polymerases using transgenic mice
- Principal Investigator
  
  HANAOKA Fumio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gakushuin University
Analysis of translesion synthesis past UV-induced DNA lesion 6-4 photoproduct in mammalian cellsPrincipal Investigator
- Principal Investigator
  
  AKAGI Jun-ichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  National Institute of Health Sciences

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2012 2011 2010

All Journal Article Presentation

[Journal Article] Effect of sequence context on Polζ-dependent error-prone extension past (6-4) photoproducts2020
- Author(s)
  Akagi J,Hashimoto K,Suzuki K,Yokoi M,de Wind N,Iwai S,Ohmori H,Moriya M,Hanaoka F
- Journal Title
  
  DNA Repair
  
  Volume: 87 Pages: 102771-102771
- DOI
  10.1016/j.dnarep.2019.102771
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12348
[Journal Article] Hypersensitivity of mouse embryonic fibroblast cells defective for DNA polymerases η, ι and κ to various genotoxic compounds: Its potential for application in chemical genotoxic screening2018
- Author(s)
  Akagi Jun-ichi、Yokoi Masayuki、Cho Young-Man、Toyoda Takeshi、Ohmori Haruo、Hanaoka Fumio、Ogawa Kumiko
- Journal Title
  
  DNA Repair
  
  Volume: 61 Pages: 76-85
- DOI
  10.1016/j.dnarep.2017.11.006
- NAID
  120006456929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00551, KAKENHI-PROJECT-16K16199, KAKENHI-PROJECT-15K14953, KAKENHI-PROJECT-15H04646
[Journal Article] Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions2015
- Author(s)
  Anastasia Tsaalbi-Shtylik, Cristina Ferrás, Bea Pauw, Giel Hendriks, Piya Temviriyanukul, Leone Carlée, Fabienne Calléja, Sandrine van Hees, Jun-Ichi Akagi, Shigenori Iwai, Fumio Hanaoka, Jacob G. Jansen, and Niels de Wind
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 209 Issue: 1 Pages: 33-46
- DOI
  10.1083/jcb.201408017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25650124, KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-15H04646
[Journal Article] The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.2012
- Author(s)
  Hashimoto K
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 12 Pages: 9613-9622
- DOI
  10.1074/jbc.m111.331728
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22131001, KAKENHI-PLANNED-22131008, KAKENHI-PROJECT-22710059, KAKENHI-PROJECT-22770172, KAKENHI-PROJECT-23510065, KAKENHI-PROJECT-22249005
[Journal Article] The vital role of polζand REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and the recruitment of polζby REV1 to a replication-stalled site2012
- Author(s)
  Hashimoto, K., Cho, Y., Yang, I. Y., Akagi, J., Ohashi, E., Tateishi, S., de Wind, N., Hanaoka, F., Ohmori, H., and Moriya, M
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 96 Pages: 9613-9622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249005
[Journal Article] Stalled Polη at its cognate substrate initiates an alternative translesion synthesis pathway via interaction with REV1.2012
- Author(s)
  Ito W
- Journal Title
  
  Genes Cells
  
  Volume: 17 Issue: 2 Pages: 98-108
- DOI
  10.1111/j.1365-2443.2011.01576.x
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22131001, KAKENHI-PLANNED-22131008, KAKENHI-PROJECT-22710059, KAKENHI-PROJECT-22249005
[Presentation] 損傷乗り越え型DNAポリメラーゼPolκとREV1はグリシドアミドN7位デオキシグアノシン付加体による点突然変異に寄与する2022
- Author(s)
  赤木純一，横井雅幸，Young-Man Cho，岩井成憲，花岡文雄，菅澤薫，小川久美子
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K12348
[Presentation] グリシドアミドN7位デオキシグアノシン付加体による点突然変異に寄与する損傷乗り越え型DNAポリメラーゼの解析2021
- Author(s)
  赤木純一, 横井雅幸, Young-Man Cho, 岩井成憲, 花岡文雄, 菅澤薫, 小川久美子
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K12348
[Presentation] アクリルアミドの活性代謝物であるグリシドアミドのデオキシグアノシンN7位付加体はDNA複製阻害と点突然変異を誘発する2020
- Author(s)
  赤木純一,横井雅幸,Young-Man Cho,岩井成憲,花岡文雄,菅澤薫,小川久美子
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K12348
[Presentation] 鋳型鎖上の2’-デオキシグアノシンN 7位グリシドアミド付加体はヒト細胞においてDNA複製を阻害し点突然変異を誘発する2020
- Author(s)
  赤木純一, 横井雅幸, 曺永晩, 岩井成憲, 花岡文雄, 菅澤薫, 小川久美子
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K12348
[Presentation] N7-グリシドアミドdG付加体により誘発されるDNA複製阻害と変異原性の解析2019
- Author(s)
  赤木純一,横井雅幸,Young-Man Cho,岩井成憲,花岡文雄,菅澤薫,小川久美子
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K12348
[Presentation] C57BL/6J野生型およびPolκ欠損マウスにおけるベンゾ[a]ピレンおよびα‐ナフトフラボン併用投与の効果2019
- Author(s)
  赤木純一, Young‐Man Cho, 豊田武士, 横井雅幸, 横井雅幸, 花岡文雄, 花岡文雄, 大森治夫, 小川久美子
- Organizer
  第35回日本毒性病理学会学術総会
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] N7グリシドアミドdG付加体は哺乳類細胞においてDNA複製を阻害する2018
- Author(s)
  赤木純一, 横井雅幸, Young-Man Cho, 岩井成憲, 花岡文雄, 小川久美子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] Benzo[a]pyrene-induced tumorigenesis in Polκ-knockout mice2018
- Author(s)
  Jun-ichi Akagi, Young-Man Cho, Takeshi Toyoda, Masayuki Yokoi, Fumio Hanaoka, Haruo Ohmori, Kumiko Ogawa
- Organizer
  The 11th 3R & 3C Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] Effect of Polκ deficiency on benzo[a]pyrene-induced tumorigenesis2018
- Author(s)
  Jun-ichi Akagi, Young-Man Cho, Takeshi Toyoda, Masayuki Yokoi, Fumio Hanaoka, Haruo Ohmori, Kumiko Ogawa
- Organizer
  5th DNA Polymerases meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] ベンゾ[a]ピレン混餌投与によるマウス前胃腫瘍発生に対するPolκの寄与2017
- Author(s)
  赤木純一、Young-Man Cho、豊田武士、水田保子、横井雅幸、花岡文雄、大森治夫、小川久美子
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] 損傷乗り越え型DNAポリメラーゼイータ・イオタ・カッパ三重欠損細胞を用いた新規遺伝毒性試験法の研究2017
- Author(s)
  赤木純一、横井雅幸、Young-Man Cho、豊田武士、大森治夫、花岡文雄、小川久美子
- Organizer
  第３回　次世代を担う若手のためのレギュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] ベンゾ[a]ピレン誘発発がんに対するPolκの寄与の解析2017
- Author(s)
  赤木純一、Young-Man Cho、豊田武士、水田保子、横井雅幸、大森治夫、花岡文雄、小川久美子
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] 損傷乗り越え型DNAポリメラーゼη・ι・κ三重欠損細胞は非代謝ベンゾ[a]ピレンに高感受性を示す2016
- Author(s)
  赤木純一, 横井雅幸, Young-Man Cho, 豊田武士, 大森治夫, 花岡文雄, 小川久美子
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-02
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] Polη, Polι,およびPolκの欠損はさまざまな化学物質に対して異なる感受性を示し、遺伝毒性のスクリーニングに有用である2016
- Author(s)
  赤木純一, 横井雅幸, 豊田武士, Young-Man Cho, 花岡文雄, 小川久美子
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] Triple knockout mouse fibroblast cells defective for DNA polymerases η, ι, and κ exhibit hypersensitivity to various genotoxic agents and increased activation of DNA damage responses2016
- Author(s)
  Jun-ichi Akagi, Masayuki Yokoi, Takeshi Toyoda, Young-Man Cho1, Haruo Ohmori, Fumio Hanaoka, Kumiko Ogawa
- Organizer
  10th 3R International Symposium
- Place of Presentation
  ホテル一畑（島根県松江市）
- Year and Date
  2016-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] 損傷乗り越えDNAポリメラーゼη・ι・κ三重欠損細胞およびPolκ欠損マウスの遺伝毒性物質曝露に対する応答2016
- Author(s)
  赤木純一, 横井雅幸, 豊田武士, 曺永晩, 西川秋佳, 大森治夫, 花岡文雄, 小川久美子
- Organizer
  第31回発癌病理研究会
- Place of Presentation
  信州松代ロイヤルホテル（長野県長野市）
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] Polη, Polι, and Polκ exhibit different genetic interactions to genotoxins of various mechanisms and the triple knockout cells are useful for screening of chemical genotoxity2016
- Author(s)
  Jun-ichi Akagi, Masayuki Yokoi, Takeshi Toyoda, Young-Man Cho, Haruo Ohmori, Fumio Hanaoka, Kumiko Ogawa
- Organizer
  Gordon Research Seminar on Mutagenesis
- Place of Presentation
  PGA Catalunya Business and Convention Centre, Girona, Spain
- Year and Date
  2016-07-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] Polη, Polι, and Polκ exhibit different genetic interactions to genotoxins of various mechanisms and the triple knockout cells are useful for screening of chemical genotoxity2016
- Author(s)
  Jun-ichi Akagi, Masayuki Yokoi, Takeshi Toyoda, Young-Man Cho, Haruo Ohmori, Fumio Hanaoka, Kumiko Ogawa
- Organizer
  Gordon Research Conference on Mutagenesis
- Place of Presentation
  PGA Catalunya Business and Convention Centre, Girona, Spain
- Year and Date
  2016-07-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16199
[Presentation] 損傷乗り越え型DNAポリメラーゼη・ι・κ三重欠損細胞の変異原に対する高感受性を用いた遺伝毒性検出法の検討2014
- Author(s)
  赤木純一, 豊田武士, Cho Young-Man, 横井雅幸, 大森治夫, 花岡文雄, 小川久美子
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-25650124
[Presentation] Site-specific replicative analysis of 6-4 photoproduct using a series of TLS polymerases deficient mouse cells2014
- Author(s)
  Jun-ichi Akagi, Keiji Hashimoto, Masayuki Yokoi, Haruo Ohmori, Sigenori Iwai, Masaaki Moriya and Fumio Hanaoka
- Organizer
  International Symposium on Xeroderma Pigmentosum and Related Diseases
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25650124
[Presentation] PolκのRev1に依存した活性が紫外線によるDNA損傷のTLSに関与する2012
- Author(s)
  鈴木健司, 赤木純一, 大橋英治, 横井雅幸, 大森治夫, 花岡文雄
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-22710059
[Presentation] TLSポリメラーゼ欠損細胞と複製ベクターを用いた細胞内TLSアッセイによる紫外線誘発DNA損傷6-4光産物の損傷乗り越え複製機構の解析2012
- Author(s)
  赤木純一, 橋本恵至, 大森治夫, 岩井成憲, 森谷正明, 花岡文雄
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-22710059
[Presentation] Polκは紫外線により誘発される突然変異の抑制に関与する2011
- Author(s)
  鈴木健司, 赤木純一, 大橋英治, 大森治夫, 横井雅幸, 花岡文雄
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22710059
[Presentation] Translesion DNA polymerase Polk acts an alternative TLS polymerase upon UV-induced DNA lesion in mouse cells2010
- Author(s)
  Jun-ichi Akagi, Kenji Suzuki, E iji Ohashi, Haruo Ohmori, Fumio Hanaoka
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22710059
[Presentation] 損傷乗り越え複製DNAポリメラーゼκはマウス細胞において紫外線誘発DNA損傷に対して予備的なTLSポリメラーゼとして働く2010
- Author(s)
  赤木純一, 鈴木健司, 大橋英治, 大雲剛志, 近藤雄二, 横井雅幸, 大森治夫, 花岡文雄
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-22710059

1. YOKOI Masayuki (00322701)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
2. HANAOKA Fumio (50012670)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
3. 岩井成憲 (10168544)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results

Akagi Jyunichi 赤木 純一

Akagi Jun-ichi 赤木 純一

AKAGI Jun-ichi 赤木 純一

Research Projects

Research Products

Co-Researchers

Analysis of mutagenicity of stable deoxyadenosine adducts produced by exposure to acrylamidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of acrylamide-induced mutagenesis via translesion synthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the molecular mechanisms of acrylamide-induced mutagenesis by using intracellular translesion synthesis assayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of a fast, convenient and sensitive genotoxicity test utilizing cells lacking DNA damage response factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of functional roles of TLS polymerases using transgenic mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of translesion synthesis past UV-induced DNA lesion 6-4 photoproduct in mammalian cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effect of sequence context on Polζ-dependent error-prone extension past (6-4) photoproducts2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypersensitivity of mouse embryonic fibroblast cells defective for DNA polymerases η, ι and κ to various genotoxic compounds: Its potential for application in chemical genotoxic screening2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The vital role of polζand REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and the recruitment of polζby REV1 to a replication-stalled site2012

Author(s)

Journal Title

Data Source

[Journal Article] Stalled Polη at its cognate substrate initiates an alternative translesion synthesis pathway via interaction with REV1.2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] 損傷乗り越え型DNAポリメラーゼPolκとREV1はグリシドアミドN7位デオキシグアノシン付加体による点突然変異に寄与する2022

Author(s)

Organizer

Data Source

[Presentation] グリシドアミドN7位デオキシグアノシン付加体による点突然変異に寄与する損傷乗り越え型DNAポリメラーゼの解析2021

Author(s)

Organizer

Data Source

Akagi Jyunichi 赤木純一

Akagi Jun-ichi 赤木純一

AKAGI Jun-ichi 赤木純一

[Presentation] 損傷乗り越え型DNAポリメラーゼイータ・イオタ・カッパ三重欠損細胞を用いた新規遺伝毒性試験法の研究2017