Ozawa Daisaku 小澤大作

… Alternative Names

OZAWA Daisaku 小澤大作

Less

Researcher Number	60554524
Other IDs
Affiliation (Current)	2025: セントラル硝子株式会社(New－STEP研究所事業開発グループ湘南リサーチセンター), 湘南リサーチセンター, 研究員
Affiliation (based on the past Project Information) *help	2023: セントラル硝子株式会社(New－STEP研究所事業開発グループ湘南リサーチセンター), 湘南リサーチセンター, 研究員 2020 – 2023: 近畿大学, 医学部, 定時職員 2017 – 2020: 大阪大学, 医学系研究科, 特任助教 2012 – 2015: 福井大学, テニュアトラック推進本部, 助教 2010 – 2011: 福井大学, 医学部, 特命助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Biophysics / Neurology Except Principal Investigator Human pathology / Experimental pathology / Basic Section 52020:Neurology-related / Biological Sciences / Structural biochemistry
Keywords	Principal Investigator アミロイド / 神経変性疾患 / ポリグルタミン蛋白質 / プリオン / ポリグルタミン / アミロイドーシス / 蛋白質品質管理 / シャペロン / 液液相分離 / 液滴 / ミスフォールディング / 液-液相分離 / 伝播 … More Except Principal Investigator … More β2-ミクログロブリン / アミロイド線維 / 透析アミロイドーシス / 蛋白質 / アミロイドーシス / 血液透析 / 細胞毒性 / 病理学 / 透析アミロイド症 / アルツハイマー病 / 液-液相分離 / ショウジョウバエ / 微小管輸送 / 凝集体 / アミロイド / 非膜性オルガネラ / 液－液相分離 / 脳神経疾患 / 滑膜線維芽細胞 / リソソーム / エンドサイトーシス / 滑膜細胞 / 透析アミロイド－シス / 血清アミロイドP成分 / トランスジェニックマウス / 細胞傷害 / C反応性蛋白質 / 血清アミロイド成分 / 細胞外シャペロン / β2‐ミクログロブリン / β2ミクログロブリン / Aβ蛋白質 / 生物物理 / 変性とフォールディング Less

Elucidation of pathomechanism and development of treatment for neurodegenerative diseases focusing on the dysregulation of liquid-liquid phase separationPrincipal Investigator
- Principal Investigator
  
  小澤大作
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  CENTRAL GLASS CO., LTD.(New-STEP Research Center, Advanced Business Group, Shonan Research Center)
Elucidation of regulation mechanisms of LLPS leading to pathological protein aggregation in neurodegenerative diseases
- Principal Investigator
  
  Nagai Yoshitaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kindai University
プリオン仮説に基づいた蛋白質モノマー間異常構造伝播の実証Principal Investigator
- Principal Investigator
  
  小澤大作
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kindai University
Transmission mechanism of abnormal conformational transition of polyglutamine proteinPrincipal Investigator
- Principal Investigator
  
  Ozawa Daisaku
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University
The mechanism of extracellular protein quality control by extracellular chaperonePrincipal Investigator
- Principal Investigator
  
  Ozawa Daisaku
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  University of Fukui
analysis of the mechanism of bone and joint destruction by beta2-microglobulin amyloid deposion
- Principal Investigator
  
  Okoshi Tadakazu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  University of Fukui
Molecular pathological environments promoting/inhibiting the development of amyloidosis: the synergistic interaction of protein science and animal models
- Principal Investigator
  
  Naiki Hironobu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
The inhibition mechanism of protein aggregation by extracellular chaperonePrincipal Investigator
- Principal Investigator
  
  OZAWA Daisaku
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  University of Fukui
analysis of the mechanism of bone and articular destruction in dialysis related amyloidosis
- Principal Investigator
  
  OOKOSHI Tadakazu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  University of Fukui
アミロイド線維形成を制御する生体分子環境及び線維沈着による細胞傷害機構の解明
- Principal Investigator
  
  内木宏延
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
Clarification of the molecular pathogenesis of human amyloidosis by in vitro amyloid fibril formation systems and transgenic mouse model
- Principal Investigator
  
  NAIKI Hironobu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  University of Fukui
Studies on the molecular mechanism of amyloid fibril formation and on the role of extracellular quality control mechanism in the fibril formation.
- Principal Investigator
  
  HESEGAWA Kazuhiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Fukui

All 2023 2022 2021 2020 2019 2018 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] いま新薬で加速する神経変性疾患研究（実験医学増刊）2023
- Author(s)
  小澤大作、永井義隆
- Total Pages
  226
- Publisher
  羊土社
- ISBN
  9784758104128
- Data Source
  KAKENHI-PROJECT-20K07737
[Book] 実験医学増刊、いま新薬で加速する神経変性疾患研究2023
- Author(s)
  小澤大作、永井義隆
- Total Pages
  226
- Publisher
  羊土社
- ISBN
  9784758104128
- Data Source
  KAKENHI-PROJECT-23K06836
[Book] 相分離　メカニズムと疾患2021
- Author(s)
  小澤大作，永井義隆
- Total Pages
  223
- Publisher
  羊土社
- ISBN
  9784758103954
- Data Source
  KAKENHI-PROJECT-20K07737
[Book] 相分離生物学の全貌2020
- Author(s)
  小澤大作、永井義隆
- Total Pages
  416
- Publisher
  東京化学同人
- ISBN
  9784807913466
- Data Source
  KAKENHI-PROJECT-20K07737
[Book] 相分離生物学の全貌2020
- Author(s)
  小澤大作、永井義隆
- Total Pages
  416
- Publisher
  東京化学同人
- ISBN
  9784807913466
- Data Source
  KAKENHI-PROJECT-17K09755
[Book] タンパク質のアモルファス凝集と溶解性2019
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Total Pages
  283
- Publisher
  シーエムシー出版
- ISBN
  9784781313979
- Data Source
  KAKENHI-PROJECT-17K09755
[Book] 変革する透析医学（透析アミロイドーシスの病態）2012
- Author(s)
  小澤大作，風間順一郎，内木宏延
- Total Pages
  5
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-24770150
[Book] 変革する透析医学透析アミロイドーシスの病態2012
- Author(s)
  小澤大作, 他
- Total Pages
  498
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-24770150
[Journal Article] FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD2023
- Author(s)
  Fujino Yuzo、Ueyama Morio、Ishiguro Taro、Ozawa Daisaku、Ito Hayato、Sugiki Toshihiko、Murata Asako、Ishiguro Akira et al.
- Journal Title
  
  eLife
  
  Volume: 12 Pages: 1-31
- DOI
  10.7554/elife.84338
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07032, KAKENHI-PROJECT-23K06836, KAKENHI-PROJECT-20K07737, KAKENHI-PROJECT-21K07432, KAKENHI-PUBLICLY-23H04265, KAKENHI-PROJECT-21H02840
[Journal Article] ALS-linked FUS mutations dysregulate G-quadruplex-dependent liquid?liquid phase separation and liquid-to-solid transition2021
- Author(s)
  Ishiguro Akira、Lu Jun、Ozawa Daisaku、Nagai Yoshitaka、Ishihama Akira
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 297 Issue: 5 Pages: 101284-101284
- DOI
  10.1016/j.jbc.2021.101284
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07439, KAKENHI-PROJECT-20K07737, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-21H02840
[Journal Article] Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation.2020
- Author(s)
  Minakawa EN, Popiel HA, Tada M, Takahashi T, Yamane H, Saitoh Y, Takahashi Y, Ozawa D, Takeda A, Takeuchi T, Okamoto Y, Yamamoto K, Suzuki M, Fujita H, Ito C, Yagihara H, Saito Y, Watase K, Adachi H, Katsuno M, Mochizuki H, Shiraki K, Sobue G, Toda T, Wada K, Onodera O, Nagai Y.
- Journal Title
  
  Brain
  
  Volume: 143 Issue: 6 Pages: 1811-1825
- DOI
  10.1093/brain/awaa115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07970, KAKENHI-PROJECT-19K07987, KAKENHI-PROJECT-20K07737, KAKENHI-PROJECT-17K09755, KAKENHI-PLANNED-20H05927
[Journal Article] アミロイドーシスの発症メカニズムについて2016
- Author(s)
  大越忠和，小澤大作，山口格，長谷川一浩，内木宏延
- Journal Title
  
  病理と臨床
  
  Volume: 34 Pages: 454-459
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] Molecular pathogenesis ofhuman amyloidosis: Lessons from β2 -microglobulin-related amyloidosis.2016
- Author(s)
  Naiki H, Okoshi T, Ozawa D, Yamaguchi I, Hasegawa K.
- Journal Title
  
  Pathol Int.
  
  Volume: ;66(4) Issue: 4 Pages: 193-201
- DOI
  10.1111/pin.12394
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460893, KAKENHI-PROJECT-26840047, KAKENHI-PROJECT-26860236, KAKENHI-PROJECT-25293094, KAKENHI-PROJECT-16H05170, KAKENHI-PROJECT-15K06965
[Journal Article] アミロイドーシスの発症メカニズムについて2016
- Author(s)
  大越忠和、小澤大作、山口格、長谷川一浩、内木宏延
- Journal Title
  
  病理と臨床
  
  Volume: 34 Pages: 454-459
- Data Source
  KAKENHI-PROJECT-26860236
[Journal Article] β2-ミクログロブリンアミロイド線維の形成機序2016
- Author(s)
  小澤大作，大越忠和，長谷川一浩，内木宏延
- Journal Title
  
  腎と骨代謝
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] Endocytosed β2-microglobulin amyloid fibrils induce necrosis and apoptosis of rabbit synovial fibroblasts by disrupting endosomal/lysosomal membranes: A novel mechanism on the cytotoxicity of amyloid fibrils.2015
- Author(s)
  Okoshi, T., Yamaguchi, I., Ozawa, D., Hasegawa, H., Naiki, H.
- Journal Title
  
  PLoS One
  
  Volume: 10
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] Endocytosed β2-Microglobulin Amyloid Fibrils Induce Necrosis and Apoptosis of Rabbit Synovial Fibroblasts by Disrupting Endosomal/Lysosomal Membranes: A Novel Mechanism on the Cytotoxicity of Amyloid Fibrils.2015
- Author(s)
  Okoshi T, Yamaguchi I, Ozawa D, Hasegawa K, Naiki H
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 9 Pages: e0139330-e0139330
- DOI
  10.1371/journal.pone.0139330
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06965, KAKENHI-PROJECT-25460893, KAKENHI-PROJECT-26840047, KAKENHI-PROJECT-26860236
[Journal Article] ヒトアミロイド線維形成・沈着の分子機構2014
- Author(s)
  内木宏延，長谷川一浩，小澤大作，大越忠和
- Journal Title
  
  Dementia Japan
  
  Volume: 28 Pages: 275-282
- Data Source
  KAKENHI-PROJECT-26840047
[Journal Article] ヒトアミロイド線維形成・沈着の分子機構2014
- Author(s)
  内木　宏延, 長谷川　一浩, 小澤　大作, 大越　忠和
- Journal Title
  
  Dementia Japan
  
  Volume: 28 Pages: 275-282
- Data Source
  KAKENHI-PROJECT-25293094
[Journal Article] Surface-bound basement membrane components accelerate amyloid-β peptide nucleation in air-free wells: An in vitro model of cerebral amyloid angiopathy.2013
- Author(s)
  Hasegawa K, Ozawa D, Ookoshi T, Naiki H
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1834 Issue: 8 Pages: 1624-1631
- DOI
  10.1016/j.bbapap.2013.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570129, KAKENHI-PROJECT-24770150, KAKENHI-PROJECT-25293094
[Journal Article] Surface-bound basement membrane components accelerate amyloid-β peptide nucleation in air-free wells: an in vitro model of cerebral amyloid angiopathy2013
- Author(s)
  Hasegawa K., Ozawa D, Ookoshi T, Naiki H
- Journal Title
  
  BiochimBiophys Acta
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Molecular mechanisms ofβ2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Journal Title
  
  The Proceedings of the XIIIth International Symposium on Amyloidosis
  
  Pages: 45-47
- Data Source
  KAKENHI-PROJECT-24770150
[Journal Article] Destruction of amyloid fibrils of keratoepithelin peptides by laser irradiation coupled with amyloid-specific thioflavin T2011
- Author(s)
  Ozawa D., et al.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Pages: 10856-10863
- NAID
  120006557644
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22020014
[Journal Article] Inhibition of β2-microglobulin amyloid fibril formation by_a2-macroglobulin.2011
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H.
- Journal Title
  
  J Biol Chem. 286(11)
  
  Pages: 9668-9676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] Inhibition of ss_2-microglobulin amyloid fibril formation by α_2-macroglobulin2011
- Author(s)
  Ozawa D, et al.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Pages: 9668-9676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Inhibition of β_2-microglobulin amyloid fibril formation by α_2-macroglobulin.2011
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Journal Title
  
  J Biol Chem
  
  Volume: 286(11) Pages: 9668-9676
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Inhibition of ss_2-microglobulin amyloid fibril formation by α_2-macroglobulin2011
- Author(s)
  Ozawa D, et al.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Pages: 9668-9876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] Destruction of amyloid fibrils of keratoepithelin peptides by laser irradiation coupled with amyloid-specific thioflavin T2011
- Author(s)
  Ozawa D, et al.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Pages: 10856-10863
- NAID
  120006557644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Inhibition of β_2-microglobulin amyloid fibril formation by α_2-macroglobulin2011
- Author(s)
  Ozawa D., et al.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Pages: 9668-9676
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22020014
[Journal Article] Destruction of amyloid fibrils of keratoepithelin peptides by laser irradiation coupled with amyloid-specific thioflavin2011
- Author(s)
  Ozawa D, Kaji Y, Yagi H, Sakurai K Kawakami T, Naiki H, Goto Y
- Journal Title
  
  T. J Biol Chem
  
  Volume: 286(12) Pages: 10856-10863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers.2010
- Author(s)
  Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H.
- Journal Title
  
  Biochim Biophys Acta. 1804(4)
  
  Pages: 986-995
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570105
[Journal Article] Mouse model to study human Aβ_2M amyloidosis: generation of a transgenic mouse with excessive expression of human β_2-microglobulin2010
- Author(s)
  Zhang P, Fu X, Sawashita J, Yao J, Zhang B, Qian J, Tomozawa H, Mori M, Ando Y, Naiki H, Higuchi K
- Journal Title
  
  Amyloid
  
  Volume: 17(2) Pages: 50-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Journal Article] Laser-induced propagation and destruction of amyloid β fibrils2010
- Author(s)
  Yagi H, Ozawa D, Sakurai K, Kawakami T, Kuyama H, Nishimura O, Shimanouchi T, Kuboi R, Naiki H, Goto Y
- Journal Title
  
  J Biol Chem
  
  Volume: 285(25) Pages: 19660-19667
- NAID
  120006557646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] FUSはRNAシャペロンとしてRAN翻訳を抑制し、C9orf72関連ALS/FTDの神経変性を改善する2023
- Author(s)
  藤野雄三、上山盛夫、石黒太郎、小澤大作、伊藤隼人、石黒亮、森康治、池田学、水野敏樹、望月秀樹、田口英樹、永井義隆
- Organizer
  第42回日本認知症学会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] FUS suppresses RAN translation and neurodegeneration through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD.2023
- Author(s)
  Fujino Y., Ueyama M., Ishiguro T., Ozawa D., Ito H., Ishiguro A., Gendron T.F., Mori K., Tokuda E., Takeuchi T., Furukawa Y., Mizuno T., Onodera O., Taguchi H., Petrucelli L., Nagai Y.
- Organizer
  11th Gordon Research Conference on CAG Triplet Repeat Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] Prion-like conformational transmission of misfolded polyglutamine protein monomer which exerts toxicity2023
- Author(s)
  Daisaku Ozawa, Toshihide Takeuchi, Yoshitaka Nagai
- Organizer
  2023 Gordon Research Conference - CAG Triplet Repeat Disorders -
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07737
[Presentation] Prion-like conformational transmission of misfolded polyglutamine protein monomer which exerts toxicity.2023
- Author(s)
  Ozawa D., Takeuchi T., Nagai Y.
- Organizer
  11th Gordon Research Conference on CAG Triplet Repeat Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] FUS suppresses RAN translation and neurodegeneration as an RNA chaperone in C9orf72-linked ALS/FTD.2023
- Author(s)
  Fujino Y. Ueyama M., Ishiguro T., Ozawa D., Ito H., Murata A., Tokuda E., Furukawa Y., Mizuno T., Mochizuki H., Mizusawa H., Wada K., Ishikawa K., Onodera O., Nakatani K., Taguchi H., Nagai Y.
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] FUS suppresses RAN translation and neurodegeneration in C9orf72-linked ALS/FTD through modulating the higher-order structures of GGGGCC repeat RNA.2023
- Author(s)
  Fujino Y., Ueyama M., Ozawa D., Ito H., Taguchi H., Mizuno T., Nagai Y.
- Organizer
  第46回日本神経科学会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] Prion-like amplification of misfolded polyglutamine protein monomer which leads to toxicity2022
- Author(s)
  Ozawa D., Takeuchi T., Nagai Y.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] Liquid to solid phase transition of full-length TDP-43 in vitro2022
- Author(s)
  Jiangkun Lu, Daisaku Ozawa, Yoshitaka Nagai
- Organizer
  第６３回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07737
[Presentation] Liquid to solid phase transition of full-length TDP-43 in vitro.2022
- Author(s)
  Lu J., Ozawa D., Nagai Y.
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] Liquid to solid phase transition of full-length TDP-43 protein2022
- Author(s)
  Lu J., Ozawa D., Nagai Y.
- Organizer
  第16回日本臨床ストレス応答学会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] Prion-like amplification of misfolded polyglutamine protein monomer which exerts toxicity2022
- Author(s)
  Daisaku Ozawa, Toshihide Takeuchi, Yoshitaka Nagai
- Organizer
  The 4th Proteostasis and Disease Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07737
[Presentation] Prion-like amplification of misfolded polyglutamine protein monomer which exerts toxicity.2022
- Author(s)
  Ozawa D., Takeuchi T., Nagai Y.
- Organizer
  The 4th Proteostasis and Disease Research Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] Prion-like amplification of misfolded polyglutamine protein monomer which leads to toxicity2022
- Author(s)
  Daisaku Ozawa, Toshihide Takeuchi, Kensuke Ikenaka, Hideki Mochizuki, Yoshitaka Nagai
- Organizer
  第６３回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07737
[Presentation] プリオン仮説に基づいたポリグルタミン蛋白質の異常構造伝播と増幅2021
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第15回日本臨床ストレス応答学会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] ポリグルタミン蛋白質のプリオン様異常構造伝播2021
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第8回日本アミロイドーシス学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07737
[Presentation] Misfolded polyglutamine protein transmits its abnormal conformation in a prion-like manner.2021
- Author(s)
  Ozawa D., Takeuchi T., Nagai Y.
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] ALS-Linked FUS mutations dysregulate G-quadruplex-dependent liquid-liquid phase separation and liquid-to-solid transition2021
- Author(s)
  Ishiguro A., Lu J., Ozawa D., Nagai Y., Ishihama A.
- Organizer
  第44回分子生物学会
- Data Source
  KAKENHI-PROJECT-21H02840
[Presentation] Misfolded polyglutamine protein transmits its abnormal conformation in a prion-like manner2021
- Author(s)
  Daisaku Ozawa, Toshihide Takeuchi, Yoshitaka Nagai
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K07737
[Presentation] プリオン仮説に基づいたポリグルタミン蛋白質の異常構造伝播と増幅2021
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第15回　日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-20K07737
[Presentation] ポリグルタミン蛋白質におけるプリオン様異常構造伝播機構2020
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第18回神経科学研究会
- Data Source
  KAKENHI-PROJECT-20K07737
[Presentation] ポリグルタミン蛋白質におけるプリオン様異常構造伝播機構2020
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第18回神経科学研究会
- Data Source
  KAKENHI-PROJECT-17K09755
[Presentation] 神経変性疾患と液-液相分離2019
- Author(s)
  小澤大作、永井義隆
- Organizer
  第２回LLPS研究会
- Data Source
  KAKENHI-PROJECT-17K09755
[Presentation] ポリグルタミン蛋白質によるプリオン様異常構造伝播2019
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第１４回日本臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-17K09755
[Presentation] ポリグルタミン蛋白質による異常構造伝播2019
- Author(s)
  小澤大作、永井義隆
- Organizer
  大阪大学蛋白質研究所セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K09755
[Presentation] ポリグルタミン蛋白質によるプリオン様異常構造伝播2019
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第７回アミロイドーシス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09755
[Presentation] Conformational transmission between polyglutamine protein monomers2019
- Author(s)
  Daisaku Ozawa, Toshihide Takeuchi, Yoshitaka Nagai
- Organizer
  Asian Pacific Prion Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09755
[Presentation] Prion-like conformational transmission of polyglutamine protein2019
- Author(s)
  Daisaku Ozawa, Toshihide Takeuchi, Yoshitaka Nagai
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09755
[Presentation] ポリグルタミン蛋白質による異常構造伝播機構の解明2018
- Author(s)
  小澤大作、武内敏秀、永井義隆
- Organizer
  第１８回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17K09755
[Presentation] Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component2016
- Author(s)
  Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H
- Organizer
  The XV International Symposium on Amyloidosis
- Place of Presentation
  Sweden
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26840047
[Presentation] C反応性蛋白質と血清アミロイドP成分の多面的シャペロン効果2016
- Author(s)
  小澤大作，野村寮，Mangione P. Patrizia，長谷川一浩，大越忠和，Porcari Riccardo，Bellotti Vittorio，内木宏延
- Organizer
  第１６回日本蛋白質科学会
- Place of Presentation
  福岡県
- Year and Date
  2016-06-07
- Data Source
  KAKENHI-PROJECT-26840047
[Presentation] 滑膜線維芽細胞に対するβ2-ミクログロブリンアミロイド線維の細胞毒性メカニズムの解析2014
- Author(s)
  大越　忠和, 山口　格, 小澤　大作, 長谷川　一浩, 内木　宏延
- Organizer
  第 2 回日本アミロイドーシス研究会学術集会
- Place of Presentation
  KKRホテル東京（東京都千代田区）
- Year and Date
  2014-08-22
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] 滑膜線維芽細胞に対するβ2‐ミクログロブリンアミロイド線維の細胞毒性メカニズムの解析2014
- Author(s)
  大越忠和、山口格、長谷川一浩、小澤大作、内木宏延
- Organizer
  第2回日本アミロイドーシス研究会
- Place of Presentation
  KKRホテル東京（東京都千代田区）
- Year and Date
  2014-08-22
- Data Source
  KAKENHI-PROJECT-26860236
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2013
- Author(s)
  小澤大作
- Organizer
  臨床ストレス応答学会シンポジウム
- Place of Presentation
  松本 (口頭発表)
- Invited
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] ビーズ表面に結合した細胞外マトリクス成分は、気液界面非存在下でアルツハイマー病βアミロイド線維の核形成を促進させる2013
- Author(s)
  長谷川　一浩, 小澤　大作, 大越　忠和, 内木　宏延
- Organizer
  日本生物物理学会第51回年会
- Place of Presentation
  京都, 京都国際会議場
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] β2-ミクログロブリンアミロイド線維の線維芽滑膜細胞に対する細胞毒性の検討2013
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  札幌, ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2013
- Author(s)
  小澤大作
- Organizer
  臨床ストレス応答学会シンポジウム
- Place of Presentation
  松本（信州大学医学部付属病院大会議室）
- Invited
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] Molecular mechanisms of β2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Organizer
  XIIIth International Symposium on Amyloidosis
- Place of Presentation
  Groningen(the Netherlands)
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] Molecular mechanisms ofβ2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, Naiki H
- Organizer
  XIIIth International Symposium on Amyloidosis
- Place of Presentation
  Groningen, the Netherlands (口頭発表およびポスター発表)
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] Molecular mechanisms of β2-microglobulin amyloid fibril formation.2012
- Author(s)
  Ozawa D
- Organizer
  XIIIth International Symposium on Amyloidosis
- Place of Presentation
  Groningen(the Netherlands)
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] Molecular mechanisms of β2-microglobulin amyloid fibril formation2012
- Author(s)
  Ozawa D, Hasegawa K, Ookoshi T, NaikiH
- Organizer
  XIII^<th>International Symposium on Amyloidosis
- Place of Presentation
  Groningen(the Netherlands)
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2012
- Author(s)
  小澤大作, 長谷川一浩, 李　映昊, 櫻井一正, 柳　浩太郎, 大越忠和, 後藤祐児, 内木宏延
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24770150
[Presentation] 細胞外シャペロンによるアミロイド線維形成抑制機構の解明2012
- Author(s)
  小澤大作, 長谷川一浩, 李映昊, 櫻井一正, 柳浩太郎, 大越忠和, 後藤祐児, 内木宏延
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 蛍光色素チオフラビン T とレーザー光によるアミロイド線維の分解.2011
- Author(s)
  小澤大作, 加治優一, 八木寿梓櫻井一正, 川上徹, 内木宏延, 後藤祐児
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] チオフラビンTとレーザー光を利用したアミロイド線維の分解2011
- Author(s)
  小澤大作, 他
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  大阪府吹田市
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] チオフラビン T とレーザー光を利用したアミロイド線維の分解2011
- Author(s)
  小澤大作, 加治優一, 八木寿梓, 櫻井一正, 川上徹, 内木宏延, 後藤祐児
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] 蛍光色素チオフラビンTとレーザー光によるアミロイド線維の分解2011
- Author(s)
  小澤大作, 他
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-22020014
[Presentation] 蛍光色素チオフラビンTとレーザー光によるアミロイド線維の分解2011
- Author(s)
  小澤大作, 他
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] チオフラビンTとレーザー光を利用したアミロイド線維の分解2011
- Author(s)
  小澤大作, 他
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  大阪府吹田市
- Data Source
  KAKENHI-PUBLICLY-22020014
[Presentation] α_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro2010
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] α_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro2010
- Author(s)
  Ozawa D., et al.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PUBLICLY-22020014
[Presentation] α_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro2010
- Author(s)
  Ozawa D., et al.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PUBLICLY-22020014
[Presentation] a_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro.2010
- Author(s)
  Ozawa D., Hasegawa K., Lee YH., Sakurai K., Yanagi K., Ookoshi T., Goto Y., Naiki H.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara.
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] レーザー照射によるアミロイド線維の増殖と崩壊2010
- Author(s)
  八木寿梓, 小澤大作, 櫻井一正, 加治優一, 川上徹, 九山浩樹, 内木宏延, 後藤祐児
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] α_2-Macroglobulin inhibits β_2-microglobulin amyloid fibril formation in vitro.2010
- Author(s)
  Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] α_2-Macroglobulin inhibits ss_2-microglobulin amyloid fibril formation in vitro2010
- Author(s)
  Ozawa D, et al.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] α_2-Macroglobulin inhibits ss_2-microglobulin amyloid fibril formation in vitro2010
- Author(s)
  Ozawa D, et al.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] Laser-induced propagation and destruction of amyloid β fibrils2010
- Author(s)
  Yagi H, Ozawa D, Sakurai K, Naiki H, Goto Y
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] α_2-Macroglobulin inhibits ss_2-microglobulin amyloid fibril formation in vitro2010
- Author(s)
  Ozawa D, et al.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-22390075
[Presentation] The role of interfaces and agitation on the fibril formation of amyloid β-protein.2010
- Author(s)
  Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H.
- Organizer
  Alzheimer's Association International Conference on Alzheimer's Disease 2010
- Place of Presentation
  Hawaii.
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] α_2-Macroglobulin inhibits ss_2-microglobulin amyloid fibril formation in vitro2010
- Author(s)
  Ozawa D, et al.
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-20570105
[Presentation] A novel cytotoxic mechanism of amyloid fibrils: Endocytosis-dependent necrosis and apoptosis of rabbit synovial fibroblasts by β2-microglobulin amyloid fibrils
- Author(s)
  T.Ookoshi, D.Ozawa, K.Hasegawa, H.Naiki
- Organizer
  XIVth International Symposium on Amyloidosis
- Place of Presentation
  Indianapolis, Indiana, USA JW Marriott Down
- Year and Date
  2014-04-27 – 2014-05-01
- Data Source
  KAKENHI-PROJECT-25293094
[Presentation] β2-ミクログロブリンアミロイド線維は滑膜線維芽細胞内に取り込まれ毒性を発揮する－形態解析を中心に－
- Author(s)
  大越　忠和, 長谷川　一浩, 小澤　大作, 内木　宏延
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場（広島県広島市）
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25293094

1. HESEGAWA Kazuhiro (60324159)

# of Collaborated Projects: 8 results

# of Collaborated Products: 30 results
2. NAIKI Hironobu (10227704)

# of Collaborated Projects: 8 results

# of Collaborated Products: 39 results
3. OOKOSHI Tadakazu (90362037)

# of Collaborated Projects: 7 results

# of Collaborated Products: 24 results
4. BAN Tadato (00579667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HIGUCHI Keiichi (20173156)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. Nagai Yoshitaka (60335354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
7. 上山盛夫 (20386593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. ADACHI Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 石黒亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 呂軍

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ozawa Daisaku 小澤 大作

OZAWA Daisaku 小澤 大作

Research Projects

Research Products

Co-Researchers

Elucidation of pathomechanism and development of treatment for neurodegenerative diseases focusing on the dysregulation of liquid-liquid phase separationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of regulation mechanisms of LLPS leading to pathological protein aggregation in neurodegenerative diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

プリオン仮説に基づいた蛋白質モノマー間異常構造伝播の実証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Transmission mechanism of abnormal conformational transition of polyglutamine proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of extracellular protein quality control by extracellular chaperonePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

analysis of the mechanism of bone and joint destruction by beta2-microglobulin amyloid deposion

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathological environments promoting/inhibiting the development of amyloidosis: the synergistic interaction of protein science and animal models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The inhibition mechanism of protein aggregation by extracellular chaperonePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

analysis of the mechanism of bone and articular destruction in dialysis related amyloidosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アミロイド線維形成を制御する生体分子環境及び線維沈着による細胞傷害機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of the molecular pathogenesis of human amyloidosis by in vitro amyloid fibril formation systems and transgenic mouse model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the molecular mechanism of amyloid fibril formation and on the role of extracellular quality control mechanism in the fibril formation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] いま新薬で加速する神経変性疾患研究（実験医学増刊）2023

Author(s)

Total Pages

Ozawa Daisaku 小澤大作

OZAWA Daisaku 小澤大作

[Book] 相分離　メカニズムと疾患2021