Ueda Takeshi 上田健

… Alternative Names

UEDA Takeshi 上田健

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Researcher Number	60585149
Other IDs
Affiliation (Current)	2025: 近畿大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 近畿大学, 医学部, 准教授 2019 – 2022: 近畿大学, 医学部, 准教授 2016 – 2018: 近畿大学, 医学部, 講師 2011 – 2016: 広島大学, 原爆放射線医科学研究所, 助教
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related Except Principal Investigator Hematology / Basic Section 50010:Tumor biology-related / Tumor biology
Keywords	Principal Investigator 造血器腫瘍 / エピジェネティクス / 遺伝子発現制御 / NEDD化 / タンパク質翻訳後修飾 / 発現制御 / 遺伝子 / 癌 / 翻訳制御 / シグナル伝達 … More Except Principal Investigator … More 白血病 / 造血幹細胞 / トランスジェニックマウス / Fbxl10 / ヒストン脱メチル化酵素 / 代謝 / 代謝異常 / マウスモデル / エピジェネティクス / 代謝制御 / がん / 組織微小環境 / ヒストンH3K27メチル化 / Jmjd3, Utx / JMJD3, UTX / PRC2 / ヒストンH3K27 / ヒストンメチル化・脱メチル化 / 骨髄異形成症候群 / コンディショナルノックアウトマウス / EED / ポリコーム複合体 / ヒストン修飾 / 酸化的リン酸化 / エネルギー代謝 / 酸化的リン酸化経路 / Kdm2b / ヒストン脱メチル化 / Fbx110 Less

Role of deregulated neddylation in acute myeloid leukemiaPrincipal Investigator
- Principal Investigator
  
  上田健
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kindai University
Elucidation of the novel epigenetic mechanism promoting a subset of hematologic malignanciesPrincipal Investigator
- Principal Investigator
  
  UEDA Takeshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kindai University
Metabolic regulation and the remodeling tissue microenvironment
- Principal Investigator
  
  Okada Hitoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kindai University
Context-dependent regulation of histone methylation in a subset of hematologic malignanciesPrincipal Investigator
- Principal Investigator
  
  UEDA Takeshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kindai University
Analysis of pathogenic mechanisms of myelodysplastic syndrome by deregulation of histone H3K27
- Principal Investigator
  
  Honda Hiroaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Role of EED mutation in hematologic malignancyPrincipal Investigator
- Principal Investigator
  
  UEDA Takeshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kindai University
  Hiroshima University
Analysis of tumorigenic mechanisms by activation of oxidative phosphorylation pathway
- Principal Investigator
  
  HONDA Hiroaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Hiroshima University
Analysis of leukemogenic mechanisms by deregulated expression of histone demethylase Fbxl10
- Principal Investigator
  
  HONDA Hiroaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Hiroshima University
Targeting Mnk/eIF4E pathway for cancer therapyPrincipal Investigator
- Principal Investigator
  
  UEDA Takeshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Hiroshima University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance2023
- Author(s)
  Dash Suman, Ueda Takeshi, Komuro Akiyoshi, Amano Hisayuki, Honda Masahiko, Kawazu Masahito, Okada Hitoshi.
- Journal Title
  
  Molecular Cancer Research
  
  Volume: online publication Issue: 5 Pages: 444-457
- DOI
  10.1158/1541-7786.mcr-22-0554
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06829, KAKENHI-PROJECT-22K11513, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-21K07135
[Journal Article] CD34+ myeloma cells with self-renewal activities are therapy-resistant and persist as MRD in cell cycle quiescence.2022
- Author(s)
  Serizawa K; Tanaka H; Ueda T; Fukui A; Kakutani H; Taniguchi T; Inoue H; Kumode T; Taniguchi Y; Rai S; Hirase C; Morita Y; Espinoza JL; Tatsumi Y; Ashida T; Matsumura I
- Journal Title
  
  Int J Hematol.
  
  Volume: 115 Issue: 3 Pages: 336-349
- DOI
  10.1007/s12185-021-03261-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-22K08490, KAKENHI-PROJECT-20K08743
[Journal Article] KDM4B promotes acute myeloid leukemia associated with AML1‐ETO by regulating chromatin accessibility2021
- Author(s)
  Ueda Takeshi、Kanai Akinori、Komuro Akiyoshi、Amano Hisayuki、Ota Kazushige、Honda Masahiko、Kawazu Masahito、Okada Hitoshi
- Journal Title
  
  FASEB BioAdvances
  
  Volume: 3 Issue: 12 Pages: 1020-1033
- DOI
  10.1096/fba.2021-00030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11486, KAKENHI-PLANNED-17H06404, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-21K06829, KAKENHI-PROJECT-21K07135, KAKENHI-PROJECT-21K12239
[Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021
- Author(s)
  Sera Y; Nakata Y; Ueda T; Yamasaki N; Koide S; Kobayashi H; Ikeda KI; Kobatake K; Iwasaki M; Oda H; Wolff L; Kanai A; Nagamachi A; Inaba T; Sotomaru Y; Ichinohe T; Koizumi M; Miyakawa Y; Honda ZI; Iwama A; Suda T; Takubo K; Honda H
- Journal Title
  
  Blood.
  
  Volume: 137 Issue: 7 Pages: 908-922
- DOI
  10.1182/blood.2019001044
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19K17918, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19H01056, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-21K08395
[Journal Article] Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction2020
- Author(s)
  Kobatake Kohei et al., Honda Zen-ichiro et al. and Honda Hiroaki
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 26 Issue: 8 Pages: 2065-2079
- DOI
  10.1158/1078-0432.ccr-19-2230
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08384, KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19K17918, KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-19K09729, KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19H01056
[Journal Article] Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin2020
- Author(s)
  Oka Naohiro、Komuro Akiyoshi、Amano Hisayuki、Dash Suman、Honda Masahiko、Ota Kazushige、Nishimura Shunji、Ueda Takeshi、Akagi Masao、Okada Hitoshi
- Journal Title
  
  Pharmacology Research & Perspectives
  
  Volume: 8 Issue: 4
- DOI
  10.1002/prp2.632
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11486, KAKENHI-PROJECT-20K07346, KAKENHI-PLANNED-17H06404, KAKENHI-PROJECT-18K06941, KAKENHI-PROJECT-18K07211
[Journal Article] High fat diet triggers a reduction in body fat mass in female mice deficient for Utx demethylase2019
- Author(s)
  Ota K, Komuro A, Amano H, Kanai A, Ge K, Ueda T, Okada H
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10036-10036
- DOI
  10.1038/s41598-019-46445-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06941, KAKENHI-PROJECT-18K07211, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-17K08679
[Journal Article] JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities2018
- Author(s)
  Kang Changkeun、Saso Kayoko、Ota Kazushige、Kawazu Masahito、Ueda Takeshi、Okada Hitoshi
- Journal Title
  
  Genes to Cells
  
  Volume: 23 Issue: 9 Pages: 767-777
- DOI
  10.1111/gtc.12627
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07211, KAKENHI-PROJECT-18K08492
[Journal Article] 骨肉腫におけるシスプラチンと抗酸化物質によるROS産生を介した抗腫瘍効果の検討2018
- Author(s)
  岡尚宏, 天野恭志, 古室暁義, 太田一成, 上田健, 西村俊司, 岡田斉, 赤木將男
- Journal Title
  
  日本整形外科学会雑誌
  
  Volume: 92 Pages: 2039-2039
- Data Source
  KAKENHI-PROJECT-18K07211
[Journal Article] Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia2017
- Author(s)
  Nakata Y, Ueda T, Nagamachi A, Yamasaki N, Ikeda KI, Sera Y, Takubo K, Kanai A, Oda H, Sanada M, Ogawa S, Tsuji K, Ebihara Y, Wolff L, Honda ZI, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood
  
  Volume: 129 Issue: 15 Pages: 2148-2160
- DOI
  10.1182/blood-2016-06-724658
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-17K08679, KAKENHI-PROJECT-15H04857, KAKENHI-PROJECT-17J05696, KAKENHI-PROJECT-16K19575
[Journal Article] Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency2016
- Author(s)
  Ikeda K-I, Ueda T, Yamasaki N, Nakata Y, Sera Y, Nagamachi A, Miyama T, Kobayashi H, TakuboK, Kanai A, Oda H, Wolff l, Honda Z-1, Ichinohe T, Matsubara A, Suda T, Inaba T, Honda H
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 29454-29454
- DOI
  10.1038/srep29454
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-16K19575
[Journal Article] ALKR1275Q perturbs extracellular matrix, enhances cell invasion and leads to the development of neuroblastoma in cooperation with MYCN.2016
- Author(s)
  Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda ZI, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H.
- Journal Title
  
  Oncogene.
  
  Volume: 無 Issue: 34 Pages: 4447-4458
- DOI
  10.1038/onc.2015.519
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-25460416, KAKENHI-PROJECT-15K14384, KAKENHI-PROJECT-26670493, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-26293242, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-16K08691
[Journal Article] Propagation of tri-methylated H3K27 regulated by EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.2016
- Author(s)
  Ueda T, Nakata Y, Nagamachi A, Yamasaki N, Kanai A, Matsui H, Honda ZI, Oda H, Wolff L, Inaba T, Honda H.
- Journal Title
  
  PNAS
  
  Volume: 113(37) Issue: 37 Pages: 10370-10375
- DOI
  10.1073/pnas.1600070113
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-15K09478, KAKENHI-PROJECT-16K19575
[Journal Article] Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg22015
- Author(s)
  Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood
  
  Volume: 125
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460391
[Journal Article] Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg22015
- Author(s)
  Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma T, Oda H, Wolff L, Honda Z, WuX, Helin K, Iwama A, Suda T, Inaba T, Honda H
- Journal Title
  
  Blood
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25640065
[Journal Article] Fbxl10 overexpression in murine hematopoietic stemcells induces leukemia involving metabolic activation and upregulation of Nsg22015
- Author(s)
  Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K Konuma T, Oda H, Wolff L, Honda Z, Wu X, Helin K, Iwama A, Suda T, Inaba T, Honda H.
- Journal Title
  
  Blood
  
  Volume: 125 Issue: 22 Pages: 3437-3446
- DOI
  10.1182/blood-2014-03-562694
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460391, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-26860735, KAKENHI-PROJECT-26293227
[Journal Article] Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling2014
- Author(s)
  Chevillard-Briet M, Quaranta M, Grézy A, Mattera L, Courilleau C, Philippe M, Mercier P, Corpet D, Lough J, Ueda T, Fukunaga R, Trouche D, Escaffit F
- Journal Title
  
  Hum Mol Genet
  
  Volume: 23(8) Pages: 2120-2131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590364
[Journal Article] Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function.2014
- Author(s)
  Nagamachi A, Nakata Y, Ueda T, Yamasaki N, Ebihara Y, Tsuji K, Honda Zi, Takubo K, Suda T, Oda H, Inaba T, Honda H
- Journal Title
  
  PLos One
  
  Volume: 9 Issue: 1 Pages: 1-10
- DOI
  10.1371/journal.pone.0087425
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390252, KAKENHI-PROJECT-23591459, KAKENHI-PROJECT-23689049, KAKENHI-PROJECT-24390272, KAKENHI-PUBLICLY-25118724, KAKENHI-PROJECT-25640065, KAKENHI-PROJECT-25670489, KAKENHI-PROJECT-26293243, KAKENHI-PROJECT-26670511
[Journal Article] Acquired deficiency of a20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function2014
- Author(s)
  Nagamachi A, Nakata Y, Ueda T, Yamasaki N, Ebihara Y, Tsuji K, Honda Z, Takubo K, Suda T, Oda H, Inaba T, Honda H
- Journal Title
  
  PLoS On
  
  Volume: 9(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590364
[Journal Article] Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p152013
- Author(s)
  Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW
- Journal Title
  
  Genes Dev
  
  Volume: 27(10) Pages: 1101-11114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590364
[Journal Article] CIZ1, a p21 (Cip1/Waf1) -interacting protein, functions as a tumor suppressor in vivo2013
- Author(s)
  Nishibe R, Watanabe W, Ueda T, Yamasaki N, Koller R, Wolff L, Honda Z, Ohtsubo M, Honda H
- Journal Title
  
  FEBS Lett
  
  Volume: 587(10) Pages: 1529-1535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590364
[Journal Article] Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model2013
- Author(s)
  Berger T, Ueda T, Arpaia E, Chio II, Shirdel EA, Jurisica I, Hamada K, You-Ten A, Haight J, Wakeham A, Cheung CC, Mak TW
- Journal Title
  
  Oncogene
  
  Volume: 32(41) Pages: 4989-4994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590364
[Journal Article] CIZ1, a p21 Cip1 /Waf1-interacting protein, functions as a tumor suppressor in vivo2013
- Author(s)
  Nishibe R, Watanabe W, Ueda T, Yamasaki N, Koller R, Wolff L, Honda Z-i, Ohtsubo M, Honda H
- Journal Title
  
  FEBS Lett
  
  Volume: 587 Pages: 1529-1535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms2012
- Author(s)
  Ueda T, Sanada M, Matsui H, Yamasaki N, Honda ZI, Shih LY, Mori H, Inaba T, Ogawa S, Honda H
- Journal Title
  
  Leukemia
  
  Volume: 26(12) Pages: 2557-2560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590364
[Journal Article] EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms2012
- Author(s)
  Ueda T, Sanada M, Matsui H, Yamasaki N, Honda Zi, Shih LY, Mori H, Inaba T, Ogawa S, Honda H
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 2557-2560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390252
[Journal Article] TRADD contributes to tumour suppression by regulating ULF-dependent p19(Arf) ubiquitylation2012
- Author(s)
  Chio II, Sasaki M, Ghazarian D, Moreno J, Done S, Ueda T, Inoue S, Chang YL, Chen NJ, Mak TW
- Journal Title
  
  Nat Cell Biol
  
  Volume: 14(6) Pages: 625-633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590364
[Journal Article] D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function2012
- Author(s)
  Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW
- Journal Title
  
  Genes Dev
  
  Volume: 26(18) Pages: 2038-2049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590364
[Journal Article] Essential role for Mnk kinases in type II interferon (IFN{gamma}) signaling and its suppressive effects on normal hematopoiesis2011
- Author(s)
  Joshi S, Sharma B, Kaur S, Majchrzak B, Ueda T, Fukunaga R, Verma AK, Fish EN, Platanias LC
- Journal Title
  
  J Biol Chem
  
  Volume: 286(8) Pages: 6017-6026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590364
[Presentation] アスコルビン酸は骨肉腫細胞へのシスプラチン感受性を増強する2020
- Author(s)
  上田健
- Organizer
  第24回　日本がん分子標的治療学会学術集会（10月6-8日）
- Data Source
  KAKENHI-PROJECT-18K07211
[Presentation] 8;21転座急性骨髄性白血病におけるエピゲノム調節因子の役割2019
- Author(s)
  上田健
- Organizer
  第92回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07211
[Presentation] 8;21転座急性骨髄性白血病におけるエピゲノム調節因子の役割2019
- Author(s)
  上田　健、金井昭教、古室暁義、天野恭志、岡田　斉
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] 急性骨髄性白血病におけるエピゲノム調節因子の役割2019
- Author(s)
  上田健
- Organizer
  第23回　日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07211
[Presentation] 急性骨髄性白血病におけるエピゲノム調節因子の役割2019
- Author(s)
  上田　健、古室暁義、天野恭志、岡田　斉
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] 急性骨髄性白血病におけるエピゲノム調節因子の役割2019
- Author(s)
  上田健、太田一成、古室暁義、天野恭志、岡田斉
- Organizer
  未来創薬医療イノベーションシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] ヒストン脱メチル化酵素KDM4Bの急性骨髄性白血病における役割2018
- Author(s)
  上田　健、金井昭教、太田一成、古室暁義、天野恭志、岡田　斉
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] 急性骨髄性白血病において高発現するヒストン脱メチル化酵素の機能解析2018
- Author(s)
  上田　健、古室暁義、天野恭志、岡田　斉
- Organizer
  第22回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] 急性骨髄性白血病におけるヒストン脱メチル化酵素KDM4Bの役割2018
- Author(s)
  上田　健
- Organizer
  第80回日本血液学会
- Data Source
  KAKENHI-PROJECT-18K07211
[Presentation] 急性骨髄性白血病におけるヒストン脱メチル化酵素KDM4Bの役割2018
- Author(s)
  上田　健、金井昭教、太田一成、古室暁義、天野恭志、岡　尚宏、岡田　斉
- Organizer
  第80回日本血液学会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] ヒストン脱メチル化酵素KDM4Bの急性骨髄性白血病における役割2018
- Author(s)
  上田　健
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07211
[Presentation] 8;21染色体転座白血病において高発現するヒストン脱メチル化酵素の機能的意義2017
- Author(s)
  上田健、金井昭教、太田一成、古室暁義、岡田　斉
- Organizer
  第40回日本分子生物学会、第90回日本生化学会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] UTX plays essential roles in hematopoietic stem cell by regulating aging-associated genes2017
- Author(s)
  世良康如、上田健、中田雄一郎、池田健一郎、山崎憲政、小田秀明、長町安希子、金井昭教、須田年生、田久保圭誉、稲葉俊哉、本田浩章
- Organizer
  第79回日本血液学会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] マウスモデルを用いたDNA損傷応答制御による治療関連白血病発症抑制の試み2017
- Author(s)
  岡田　斉、古室暁義、上田　健
- Organizer
  第21回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] ヒストン脱メチル化酵素の乳がん発症・進展における役割2017
- Author(s)
  岡田　斉、古室暁義、上田　健、太田一成
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08679
[Presentation] ヒストン脱メチル化酵素Fbxl10の白血病発症における機能解析2016
- Author(s)
  上田健、池田健一郎
- Organizer
  第20回日本がん分子標的治療学会
- Place of Presentation
  別府国際コンベンションセンター (大分)
- Year and Date
  2016-05-31
- Data Source
  KAKENHI-PROJECT-26460391
[Presentation] EED変異体によるPRC2活性化障害の造血器腫瘍発症における役割2016
- Author(s)
  上田健、中田雄一郎、長町安希子、山崎憲政、金井昭教、松井啓隆、稲葉俊哉、本田浩章
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター (宮城)
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26460391
[Presentation] Jmjd3コンディショナルノックインマウスにおける白血病感受性亢進機構の解析2016
- Author(s)
  池田健一郎、上田健、長町安希子、山崎憲政、中田雄一郎、世良康如、小畠浩平、稲葉俊哉、本田浩章
- Organizer
  第75回日本癌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-26293227
[Presentation] ヒストン脱メチル化酵素Fbxl10の白血病における機能解析2015
- Author(s)
  上田　健、長町安希子、中田雄一郎、山崎憲政、稲葉俊哉、本田浩章
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学大会　合同大会（ポスター)
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460391
[Presentation] Haploinsufficiency of Eed enhances to tumor susceptibility and develop leukemia with overexpression of Evi12015
- Author(s)
  Kenichiro Ikeda, Takeshi Ueda, Akiko Nagamachi, Norimasa Yamasaki, Yuichiro Nakata, Toshiya Inaba, Hiroaki Honda
- Organizer
  The 74th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Year and Date
  2015-09-29
- Data Source
  KAKENHI-PROJECT-26293227
[Presentation] Functional analysis of UTX, a histone demethylase for H3K27, in normal hematopoiesis and hematologic malignancies2015
- Author(s)
  Yasuyuki Sera, Takeshi Ueda, Yuichiro Nakata, Ken-ichiro Ikeda, Norimasa Yamasaki, Hideaki Oda, Zen-ichiro Honda and Hiroaki Honda
- Organizer
  The 77th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Kanazawa
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26293227
[Presentation] Disease-associated EED Ile363Met mutation increases susceptibility to hematologic malignancies2014
- Author(s)
  上田　健, 長町安希子,中田雄一郎, 山崎憲政, 松井啓隆, 本田浩章
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-26460391
[Presentation] Role of disease-related EED Ile363Met mutant in embryonic development and tumorigenesis2014
- Author(s)
  Takeshi Ueda, Masashi Sanada, Hirotaka Matsui, Norimasa Yamasaki, Zen-ichiro Honda, Lee-Yung Shih, Hiraku Mori, Toshiya Inaba, Seishi Ogawa, and Hiroaki Honda
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] Role of disease-related EED Ile363Met mutant in embryonic development and tumorigenesis2013
- Author(s)
  Takeshi Ueda, Masashi Sanada, Hirotaka Matsui, Norimasa Yamasaki, Zen-ichiro Honda, Lee-Yung Shih, Hiraku Mori, Toshiya Inaba, Seishi Ogawa, Hiroaki Honda
- Organizer
  日本血液学会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25640065
[Presentation] Identification of interacting partners for MAP kinase-interacting kinase 12013
- Author(s)
  上田健, 福永理己郎, Roumiana Alexandrova, Theo Goh, Tak W. Mak, 本田浩章
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜
- Year and Date
  2013-09-11
- Data Source
  KAKENHI-PROJECT-23590364
[Presentation] 遺伝子改変マウスを用いた造血器腫瘍関連EED Ile363Met変異体の解析2013
- Author(s)
  上田健, 真田昌, 松井啓隆, 山崎憲政, 本田善一郎, 森啓, LEE-YUNG SHIH, 稲葉俊哉, 小川誠司, 本田浩章
- Organizer
  第75回日本血液学会
- Place of Presentation
  札幌
- Year and Date
  2013-10-12
- Data Source
  KAKENHI-PROJECT-23590364
[Presentation] MDSで同定されたポリコーム複合体PRC2構成因子EEDの機能欠失型変異体の解析2012
- Author(s)
  上田健, 真田昌, 松井啓隆, 山崎憲政, 本田善一郎, 森啓, LEE-YUNG SHIH, 稲葉俊哉, 小川誠司, 本田浩章
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-23590364
[Presentation] MDSで同定されたポリコローム複合体構成因子EEDの機能欠失型変異体の解析2012
- Author(s)
  上田健, 真田晶, 松井啓隆, 山崎憲政, 本田善一郎, 森啓, LEE-YUNG SHIH 稲葉俊哉, 小川誠司, 本田浩章
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] 癌の治療標的としてのMnk/eIF4E経路2011
- Author(s)
  上田健
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23590364
[Presentation] Eed mutations impairing polycomb repressive complex 2 function in myelodysplastic syndrome2011
- Author(s)
  上田健、真田昌、松井啓隆、山崎憲政、本田善一郎、Lee-Yung Shih、森啓、稲葉俊哉、小川誠司、本田浩章
- Organizer
  日本血液学
- Place of Presentation
  名古屋
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] 骨髄異形成症候群におけるポリコローム複合体PRC構成因子EDDの機構欠失型変異2011
- Author(s)
  上田健, 真田晶, 松井啓隆, 山崎憲政, 本田善一郎, 森啓, LEE-YUNG SHIH, 稲葉俊哉, 小川誠司, 本田浩章
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23390252
[Presentation] 骨髄異形成症候群におけるポリコーム複合体PRC2構成因子EEDの機能欠失型変異2011
- Author(s)
  上田健, 真田昌, 松井啓隆, 山崎憲政, 本田善一郎, 森啓, LEE-YUNG SHIH, 稲葉俊哉, 小川誠司, 本田浩章
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-23590364
[Presentation] 癌の治療標的としてのMnk/eIF4E経路2011
- Author(s)
  上田　健
- Organizer
  日本生化学会(招待講演)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23590364
[Presentation] Identification of interacting partners for MAP kinase-interacting kinase 1
- Author(s)
  上田　健、福永理己郎、Roumiana Alexandrova、Theo Goh、Tak W. Mak、本田浩章
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590364

1. HONDA Hiroaki (40245064)

# of Collaborated Projects: 5 results

# of Collaborated Products: 26 results
2. 金井昭教 (60549567)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. INABA Toshiya (60281292)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. HONDA Zen-ichiro (70238814)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. FUKUNAGA Rikiro (40189965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. Okada Hitoshi (20280620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 天野恭志 (20549331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 古室暁義 (50512274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 太田一成 (70589928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. HONDA Masahiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. TAKUBO Keiyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. ICHI Ikuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. SANADA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 須田年生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 松井啓隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ueda Takeshi 上田 健

UEDA Takeshi 上田 健

Research Projects

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Co-Researchers

Role of deregulated neddylation in acute myeloid leukemiaPrincipal Investigator

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Elucidation of the novel epigenetic mechanism promoting a subset of hematologic malignanciesPrincipal Investigator

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Metabolic regulation and the remodeling tissue microenvironment

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Context-dependent regulation of histone methylation in a subset of hematologic malignanciesPrincipal Investigator

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Analysis of pathogenic mechanisms of myelodysplastic syndrome by deregulation of histone H3K27

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Role of EED mutation in hematologic malignancyPrincipal Investigator

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Analysis of tumorigenic mechanisms by activation of oxidative phosphorylation pathway

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Analysis of leukemogenic mechanisms by deregulated expression of histone demethylase Fbxl10

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Targeting Mnk/eIF4E pathway for cancer therapyPrincipal Investigator

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[Journal Article] MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance2023

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[Journal Article] CD34+ myeloma cells with self-renewal activities are therapy-resistant and persist as MRD in cell cycle quiescence.2022

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[Journal Article] KDM4B promotes acute myeloid leukemia associated with AML1‐ETO by regulating chromatin accessibility2021

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[Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021

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[Journal Article] Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction2020

Ueda Takeshi 上田健

UEDA Takeshi 上田健