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NAGANO Hiromi  永野 広海

ORCIDConnect your ORCID iD *help
Researcher Number 60613148
Other IDs
Affiliation (Current) 2025: 鹿児島大学, 医歯学域鹿児島大学病院, 講師
Affiliation (based on the past Project Information) *help 2020 – 2025: 鹿児島大学, 医歯学域鹿児島大学病院, 講師
2022: 鹿児島大学, 医歯学域医学系, 講師
2018 – 2019: 鹿児島大学, 医歯学域医学系, 講師
2015 – 2017: 鹿児島大学, 医歯学域医学系, 助教
2012 – 2014: 鹿児島大学, 医歯(薬)学総合研究科, 助教
2011 – 2012: 鹿児島大学, 大学院・医歯学総合研究科, 助教
Review Section/Research Field
Principal Investigator
Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology
Except Principal Investigator
Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology / Basic Section 52040:Radiological sciences-related
Keywords
Principal Investigator
粘膜免疫 / 粘膜免疫応答 / 特異的IgA / ホスホリルコリン / 経皮免疫 / IgA / 鼻腔投与 / ワクチン / Poly(I:C) / PspA … More / streptococcus pneumoniae / 経眼投与 / 感染症 / マイクロニードル / 経皮ワクチン / コレラトキシン … More
Except Principal Investigator
粘膜免疫 / 経鼻免疫 / 経鼻ワクチン / 粘膜ワクチン / ホスホリルコリン / 舌下免疫 / ワクチン / 肺炎球菌 / アレルギー / アレルギー性鼻炎 / 粘膜免疫応答 / 経皮免疫 / 感染防御 / 免疫強化 / 分泌型IgA / MRI / pH / CEST / マウス喉頭手術 / 気道粘膜再生 / 粘膜傷害抑制 / 喉頭気管粘膜 / 悪性腫瘍 / 感染 / 希少糖 / 創傷治癒 / 上気道傷害 / P6 / PspA / 結合型ホスホリルコリン / 結合型ホスホリルコリ重合体(R-MPC) / 細菌接着性 / 結合型ホスホリルコリン重合体 / IgE / ハプテン作用 / アジュバント作用 / アジュバント / Th1/Th2型免疫応答 / 粘膜アジュバント / 広域スペクトラム / Th1/Th2型免疫応答 / ホスホリルコリン重合体 / Poly(I;C) / 上気道感染症 / Th17 / 自然免疫 / Poly(I:C) / 肺炎球菌ワクチン / PCV13 / 小児中耳炎 / 追加免疫 / 投与方法 / 注射ワクチン / 血小板活性化因子受容体 / ブースター効果 / 二相作用 / インフルエンザ菌 / 抗PC抗体 / バイオフィルム / 細菌接着 / 抗炎症作用 / IgA腎症 / PC-KLH / Phoshorylcholine(PC) / 特異的抗体価 / コレラトキシン / ホスホリルコリン / 特異的IgA / コレラトキシン Less
  • Research Projects

    (13 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (23 People)
  •  経皮感作が鼻副鼻腔アレルギー性疾患の発症に関与するメカニズムの解明と予防法を探索Principal Investigator

    • Principal Investigator
      永野 広海
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Kagoshima University
  •  腫瘍内pH環境を画像化するpH-CESTの開発と頭頚部悪性腫瘍への応用

    • Principal Investigator
      内匠 浩二
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Kagoshima University
  •  Heterologous prime boost strategyを利用した粘膜免疫を誘導するワクチンの開発

    • Principal Investigator
      大堀 純一郎
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Kagoshima University
  •  Intranasolacrimal immunization for induction of secretory IgA responses in the respiratory tract.Principal Investigator

    • Principal Investigator
      永野 広海
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Kagoshima University
  •  Research for damage suppression and regenerative therapy in vocal fold mucosa

    • Principal Investigator
      山下 勝
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Kagoshima University
  •  Development of a wide-spectrum vaccine using a new mucosal adjuvant

    • Principal Investigator
      Kurono Yuichi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Kagoshima University
  •  Toll様受容体リガンドを用いた自然免疫作動型感染症予防・治療薬開発に関する研究

    • Principal Investigator
      馬越 瑞夫
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Department of Clinical Research, National Hospital Organization Kagoshima Medical
      Kagoshima University
  •  Development of nasal boost immunization with phosphorylcholine as a novel pneumococcal vaccination program

    • Principal Investigator
      MASEDA Yoshiko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Kagoshima University
  •  Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responsesPrincipal Investigator

    • Principal Investigator
      Nagano Hiromi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Kagoshima University
  •  Development of novel mucosal vaccine by applying the biphasic reaction of phosphorylcholine

    • Principal Investigator
      Kurono Yuichi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Kagoshima University
  •  Application of phosphorylcholine for multi-functional mucosal vaccine

    • Principal Investigator
      KURONO YUICHI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Kagoshima University
  •  Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses in BALB/c micePrincipal Investigator

    • Principal Investigator
      NAGANO Hiromi
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Kagoshima University
  •  Transcutaneous immunization induces antigen specific mucosal and syatemic immune responses in mice

    • Principal Investigator
      MASEDA Yoshiko
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Kagoshima University

All 2023 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Intranasolacrimal Immunization of Mice with Pneumococcal Surface Protein A Plus Poly(I:C) Protective Against Nasopharyngeal Carriage of Streptococcus pneumonia2023

    • Author(s)
      Hiromi Nagano, Issei Nagano, Masaki Kawabata, Junichiro Ohori and Yuichi Kurono
    • Journal Title

      American Journal of Otolaryngology and Head and Neck Surgery

      Volume: 5 Pages: 1-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09669
  • [Journal Article] Intranasal immunization with phosphorylcholine suppresses allergic rhinitis in mice2018

    • Author(s)
      Keiichi Miyashita,MD, Junichiro Ohori,MD,PhD, Hiromi Nagano, MD, Satoshi Fukuyama,MD, PhD, Yuichi Kurono, MD,PhD
    • Journal Title

      The Laryngoscope

      Volume: 128(7) Issue: 7

    • DOI

      10.1002/lary.27030

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11239
  • [Journal Article] Mucosal and systemic immune response to sublingual or intranasal immunization with phosphorylcholine2018

    • Author(s)
      Maseda Yoshiko、Ohori Junichiro、Tanaka Norimitsu、Nagano Hiromi、Miyashita Keiichi、Kurono Yuichi
    • Journal Title

      Auris Nasus Larynx

      Volume: 45 Issue: 2 Pages: 273-280

    • DOI

      10.1016/j.anl.2017.04.009

    • NAID

      130007589878

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11239
  • [Journal Article] Transcutaneous immunization in auricle skin induces antigen-specific mucosal and systemic immune responses in BALB/c mice2017

    • Author(s)
      Nagano H., Jimura T., Nagano M., Miyashita K., Kurono Y.
    • Journal Title

      Auris Nasus Larynx

      Volume: 44 Issue: 4 Pages: 411-416

    • DOI

      10.1016/j.anl.2016.08.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K11238, KAKENHI-PROJECT-16K11239
  • [Journal Article] Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses in BALB/c mice.2015

    • Author(s)
      Nagano H, Kurono Y,
    • Journal Title

      Auris Nasus Larynx

      Volume: 42(6) Pages: 478-482

    • NAID

      130005125114

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25462689
  • [Journal Article] コレラトキシン経皮免疫による粘膜免疫応答2012

    • Author(s)
      永野広海
    • Journal Title

      日本口腔・咽頭科学会

      Volume: 25(1) Pages: 79-84

    • NAID

      10030552707

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591911
  • [Presentation] 13価肺炎球菌結合型ワクチン経鼻投与による免疫誘導2023

    • Author(s)
      宮本 佑美、大堀 純一郎、川畠 雅樹、永野 広海、山下 勝
    • Organizer
      第3回 日本耳鼻咽喉科免疫アレルギー感染症学会
    • Data Source
      KAKENHI-PROJECT-22K09708
  • [Presentation] Transcutaneous immunization with pneumococcal surface protein A in mice2018

    • Author(s)
      Hiromi Nagano
    • Organizer
      The 17th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11238
  • [Presentation] PspA経皮ワクチンによる免疫応答の誘導2018

    • Author(s)
      永野広海
    • Organizer
      第119回日本耳鼻咽喉科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-16K11238
  • [Presentation] PspA点眼投与による上気道粘膜免疫応答の誘導2018

    • Author(s)
      永野広海
    • Organizer
      第36回日本耳鼻咽喉科免疫アレルギー学会
    • Data Source
      KAKENHI-PROJECT-16K11238
  • [Presentation] PspA点眼投与による上気道粘膜免疫応答の誘導2017

    • Author(s)
      永野広海
    • Organizer
      第30回日本口腔・咽頭科学会総会ならびに学術講演会
    • Data Source
      KAKENHI-PROJECT-16K11238
  • [Presentation] 耳介経皮免疫によるホスホリルコリン特異的粘膜免疫応答の誘導2016

    • Author(s)
      永野広海
    • Organizer
      第117回日本耳鼻咽喉科学会通常総会・学術講演会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-16K11238
  • [Presentation] 耳介経皮免疫による粘膜免疫応答の誘導2015

    • Author(s)
      永野広海
    • Organizer
      第25回日本耳科学会総会学術講演会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-10-07
    • Data Source
      KAKENHI-PROJECT-25462689
  • [Presentation] CTおよびPC経皮免疫による粘膜免疫応答の経時的変化について2014

    • Author(s)
      永野広海
    • Organizer
      第32回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      徳島市
    • Data Source
      KAKENHI-PROJECT-25861572
  • [Presentation] CTおよびPC経皮免疫による粘膜免疫応答の経時的変化について2014

    • Author(s)
      永野広海
    • Organizer
      第32回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      徳島市
    • Data Source
      KAKENHI-PROJECT-25462689
  • [Presentation] コレラトキシン経皮免疫による粘膜免疫応答2013

    • Author(s)
      永野広海
    • Organizer
      第26回日本口腔・咽頭科学会総会学術講演会
    • Place of Presentation
      名古屋市
    • Data Source
      KAKENHI-PROJECT-25462689
  • [Presentation] コレラトキシン経皮免疫による粘膜免疫応答2013

    • Author(s)
      永野広海
    • Organizer
      第26回日本口腔・咽頭科学会総会学術講演会
    • Place of Presentation
      名古屋市
    • Data Source
      KAKENHI-PROJECT-25861572
  • [Presentation] PC経皮免疫による粘膜免疫応答の誘導2013

    • Author(s)
      永野広海
    • Organizer
      第114回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-25861572
  • [Presentation] PC経皮免疫による粘膜免疫応答の誘導2013

    • Author(s)
      永野広海
    • Organizer
      第114回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-25462689
  • [Presentation] PC経皮免疫による粘膜免疫応答の誘導2013

    • Author(s)
      永野広海
    • Organizer
      第31回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      倉敷市
    • Data Source
      KAKENHI-PROJECT-22591911
  • [Presentation] PC 経皮免疫による粘膜免疫応答の誘導2013

    • Author(s)
      永野広海
    • Organizer
      第31回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      倉敷
    • Data Source
      KAKENHI-PROJECT-22591911
  • [Presentation] PC経皮免疫による粘膜免疫応答の誘導2012

    • Author(s)
      永野広海
    • Organizer
      第10回日本ワクチン学会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-22591911
  • [Presentation] Transcutaneous immunization with cholera toxin in BALB/c mice2012

    • Author(s)
      H.Nagano
    • Organizer
      The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-22591911
  • [Presentation] コレラトキシン経皮免疫による粘膜免疫応答の誘導2012

    • Author(s)
      永野広海
    • Organizer
      第30回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大津市
    • Year and Date
      2012-02-17
    • Data Source
      KAKENHI-PROJECT-22591911
  • [Presentation] Transcutaneous immunization with cholera toxin in BALB/C mice.2012

    • Author(s)
      H. Nagano
    • Organizer
      he 14thJapan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-22591911
  • [Presentation] PC 経皮免疫による粘膜免疫応答の誘導2012

    • Author(s)
      永野広海
    • Organizer
      第10回日本ワクチン学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22591911
  • [Presentation] Phosphorylcholineを用いた経皮免疫について2011

    • Author(s)
      永野広海
    • Organizer
      第26回九州連合地方部会学術講演会
    • Place of Presentation
      久留米市
    • Year and Date
      2011-07-10
    • Data Source
      KAKENHI-PROJECT-22591911
  • [Presentation] コレラトキシン経皮免疫による口腔粘膜免疫応答の誘導2011

    • Author(s)
      永野広海
    • Organizer
      第24回日本口腔・咽頭科学会総会学術講演会
    • Place of Presentation
      広島市
    • Year and Date
      2011-09-08
    • Data Source
      KAKENHI-PROJECT-22591911
  • [Presentation] ヒアルロン酸マイクロニードルを用いた経皮免疫

    • Author(s)
      永野広海
    • Organizer
      第33回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      東京(東武ホテルレバント東京)
    • Year and Date
      2015-02-26 – 2015-02-28
    • Data Source
      KAKENHI-PROJECT-25861572
  • [Presentation] ヒアルロン酸マイクロニードルを用いた経皮免疫

    • Author(s)
      永野広海
    • Organizer
      第33回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      東京(東武ホテルレバント東京)
    • Year and Date
      2015-02-26 – 2015-02-28
    • Data Source
      KAKENHI-PROJECT-25462689
  • 1.  KURONO Yuichi (80153427)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 4 results
  • 2.  MIYASHITA Keiichi (30585063)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 3 results
  • 3.  大堀 純一郎 (90507162)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 4 results
  • 4.  KAWABATA MASAKI (30585112)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 2 results
  • 5.  MAKISE Takao (30585120)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  MASEDA Yoshiko (70535666)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  地村 友宏 (10709596)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 8.  山下 勝 (10635519)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 9.  田淵 みな子 (90838187)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  井内 寛之 (90645285)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  宮之原 郁代 (40305131)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  MATSUNE Shoji (00253899)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  原田 みずえ (20585103)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  馬越 瑞夫 (30596325)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  丸山 征郎 (20082282)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  内匠 浩二 (50535820)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  長野 広明 (70778282)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  中之薗 良太 (00985088)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  上村 清央 (30593652)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  岩永 崇 (40444830)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  大塚 洋和 (40973699)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  田畑 和宏 (80419655)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  吉浦 敬 (40322747)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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