NAGANO Hiromi 永野広海

Researcher Number	60613148
Other IDs
Affiliation (Current)	2025: 鹿児島大学, 医歯学域鹿児島大学病院, 講師
Affiliation (based on the past Project Information) *help	2020 – 2025: 鹿児島大学, 医歯学域鹿児島大学病院, 講師 2022: 鹿児島大学, 医歯学域医学系, 講師 2018 – 2019: 鹿児島大学, 医歯学域医学系, 講師 2015 – 2017: 鹿児島大学, 医歯学域医学系, 助教 2012 – 2014: 鹿児島大学, 医歯(薬)学総合研究科, 助教 2011 – 2012: 鹿児島大学, 大学院・医歯学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator 粘膜免疫 / 粘膜免疫応答 / 特異的IgA / ホスホリルコリン / 経皮免疫 / IgA / 鼻腔投与 / ワクチン / Poly(I:C) / PspA … More / streptococcus pneumoniae / 経眼投与 / 感染症 / ﾏｲｸﾛニードル / 経皮ワクチン / コレラトキシン … More Except Principal Investigator 粘膜免疫 / 経鼻免疫 / 経鼻ワクチン / 粘膜ワクチン / ホスホリルコリン / 舌下免疫 / ワクチン / 肺炎球菌 / アレルギー / アレルギー性鼻炎 / 粘膜免疫応答 / 経皮免疫 / 感染防御 / 免疫強化 / 分泌型IgA / MRI / pH / CEST / マウス喉頭手術 / 気道粘膜再生 / 粘膜傷害抑制 / 喉頭気管粘膜 / 悪性腫瘍 / 感染 / 希少糖 / 創傷治癒 / 上気道傷害 / P6 / PspA / 結合型ホスホリルコリン / 結合型ホスホリルコリ重合体（R-MPC） / 細菌接着性 / 結合型ホスホリルコリン重合体 / IgE / ハプテン作用 / アジュバント作用 / アジュバント / Th１/Th２型免疫応答 / 粘膜アジュバント / 広域スペクトラム / Th1/Th2型免疫応答 / ホスホリルコリン重合体 / Poly(I;C) / 上気道感染症 / Th17 / 自然免疫 / Poly(I:C) / 肺炎球菌ワクチン / PCV13 / 小児中耳炎 / 追加免疫 / 投与方法 / 注射ワクチン / 血小板活性化因子受容体 / ブースター効果 / 二相作用 / インフルエンザ菌 / 抗PC抗体 / バイオフィルム / 細菌接着 / 抗炎症作用 / IgA腎症 / PC-KLH / Phoshorylcholine(PC) / 特異的抗体価 / ｺﾚﾗﾄｷｼﾝ / ﾎｽﾎﾘﾙｺﾘﾝ / 特異的IgA / コレラトキシン Less

経皮感作が鼻副鼻腔アレルギー性疾患の発症に関与するメカニズムの解明と予防法を探索Principal Investigator
- Principal Investigator
  
  永野広海
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kagoshima University
腫瘍内pH環境を画像化するpH-CESTの開発と頭頚部悪性腫瘍への応用
- Principal Investigator
  
  内匠浩二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kagoshima University
Heterologous prime boost strategyを利用した粘膜免疫を誘導するワクチンの開発
- Principal Investigator
  
  大堀純一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kagoshima University
Intranasolacrimal immunization for induction of secretory IgA responses in the respiratory tract.Principal Investigator
- Principal Investigator
  
  永野広海
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kagoshima University
Research for damage suppression and regenerative therapy in vocal fold mucosa
- Principal Investigator
  
  山下勝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kagoshima University
Development of a wide-spectrum vaccine using a new mucosal adjuvant
- Principal Investigator
  
  Kurono Yuichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kagoshima University
Toll様受容体リガンドを用いた自然免疫作動型感染症予防・治療薬開発に関する研究
- Principal Investigator
  
  馬越瑞夫
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Department of Clinical Research, National Hospital Organization Kagoshima Medical
  Kagoshima University
Development of nasal boost immunization with phosphorylcholine as a novel pneumococcal vaccination program
- Principal Investigator
  
  MASEDA Yoshiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University
Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responsesPrincipal Investigator
- Principal Investigator
  
  Nagano Hiromi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University
Development of novel mucosal vaccine by applying the biphasic reaction of phosphorylcholine
- Principal Investigator
  
  Kurono Yuichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University
Application of phosphorylcholine for multi-functional mucosal vaccine
- Principal Investigator
  
  KURONO YUICHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University
Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses in BALB/c micePrincipal Investigator
- Principal Investigator
  
  NAGANO Hiromi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University
Transcutaneous immunization induces antigen specific mucosal and syatemic immune responses in mice
- Principal Investigator
  
  MASEDA Yoshiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Kagoshima University

All 2023 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Intranasolacrimal Immunization of Mice with Pneumococcal Surface Protein A Plus Poly(I:C) Protective Against Nasopharyngeal Carriage of Streptococcus pneumonia2023
- Author(s)
  Hiromi Nagano, Issei Nagano, Masaki Kawabata, Junichiro Ohori and Yuichi Kurono
- Journal Title
  
  American Journal of Otolaryngology and Head and Neck Surgery
  
  Volume: 5 Pages: 1-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09669
[Journal Article] Intranasal immunization with phosphorylcholine suppresses allergic rhinitis in mice2018
- Author(s)
  Keiichi Miyashita,MD, Junichiro Ohori,MD,PhD, Hiromi Nagano, MD, Satoshi Fukuyama,MD, PhD, Yuichi Kurono, MD,PhD
- Journal Title
  
  The Laryngoscope
  
  Volume: 128(7) Issue: 7
- DOI
  10.1002/lary.27030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11239
[Journal Article] Mucosal and systemic immune response to sublingual or intranasal immunization with phosphorylcholine2018
- Author(s)
  Maseda Yoshiko、Ohori Junichiro、Tanaka Norimitsu、Nagano Hiromi、Miyashita Keiichi、Kurono Yuichi
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 45 Issue: 2 Pages: 273-280
- DOI
  10.1016/j.anl.2017.04.009
- NAID
  130007589878
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11239
[Journal Article] Transcutaneous immunization in auricle skin induces antigen-specific mucosal and systemic immune responses in BALB/c mice2017
- Author(s)
  Nagano H., Jimura T., Nagano M., Miyashita K., Kurono Y.
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 44 Issue: 4 Pages: 411-416
- DOI
  10.1016/j.anl.2016.08.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11238, KAKENHI-PROJECT-16K11239
[Journal Article] Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses in BALB/c mice.2015
- Author(s)
  Nagano H, Kurono Y,
- Journal Title
  
  Auris Nasus Larynx
  
  Volume: 42(6) Pages: 478-482
- NAID
  130005125114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462689
[Journal Article] コレラトキシン経皮免疫による粘膜免疫応答2012
- Author(s)
  永野広海
- Journal Title
  
  日本口腔・咽頭科学会
  
  Volume: 25(1) Pages: 79-84
- NAID
  10030552707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] 13価肺炎球菌結合型ワクチン経鼻投与による免疫誘導2023
- Author(s)
  宮本　佑美、大堀　純一郎、川畠　雅樹、永野　広海、山下　勝
- Organizer
  第3回　日本耳鼻咽喉科免疫アレルギー感染症学会
- Data Source
  KAKENHI-PROJECT-22K09708
[Presentation] Transcutaneous immunization with pneumococcal surface protein A in mice2018
- Author(s)
  Hiromi Nagano
- Organizer
  The 17th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11238
[Presentation] PspA経皮ワクチンによる免疫応答の誘導2018
- Author(s)
  永野広海
- Organizer
  第１１９回日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-16K11238
[Presentation] PspA点眼投与による上気道粘膜免疫応答の誘導2018
- Author(s)
  永野広海
- Organizer
  第３６回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-16K11238
[Presentation] PspA点眼投与による上気道粘膜免疫応答の誘導2017
- Author(s)
  永野広海
- Organizer
  第３０回日本口腔・咽頭科学会総会ならびに学術講演会
- Data Source
  KAKENHI-PROJECT-16K11238
[Presentation] 耳介経皮免疫によるホスホリルコリン特異的粘膜免疫応答の誘導2016
- Author(s)
  永野広海
- Organizer
  第１１７回日本耳鼻咽喉科学会通常総会・学術講演会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-16K11238
[Presentation] 耳介経皮免疫による粘膜免疫応答の誘導2015
- Author(s)
  永野広海
- Organizer
  第２５回日本耳科学会総会学術講演会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-25462689
[Presentation] CTおよびPC経皮免疫による粘膜免疫応答の経時的変化について2014
- Author(s)
  永野広海
- Organizer
  第３２回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  徳島市
- Data Source
  KAKENHI-PROJECT-25861572
[Presentation] CTおよびPC経皮免疫による粘膜免疫応答の経時的変化について2014
- Author(s)
  永野広海
- Organizer
  第３２回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  徳島市
- Data Source
  KAKENHI-PROJECT-25462689
[Presentation] コレラトキシン経皮免疫による粘膜免疫応答2013
- Author(s)
  永野広海
- Organizer
  第２６回日本口腔・咽頭科学会総会学術講演会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-25462689
[Presentation] コレラトキシン経皮免疫による粘膜免疫応答2013
- Author(s)
  永野広海
- Organizer
  第２６回日本口腔・咽頭科学会総会学術講演会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-25861572
[Presentation] PC経皮免疫による粘膜免疫応答の誘導2013
- Author(s)
  永野広海
- Organizer
  第１１４回日本耳鼻咽喉科学会総会・学術講演会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-25861572
[Presentation] PC経皮免疫による粘膜免疫応答の誘導2013
- Author(s)
  永野広海
- Organizer
  第１１４回日本耳鼻咽喉科学会総会・学術講演会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-25462689
[Presentation] PC経皮免疫による粘膜免疫応答の誘導2013
- Author(s)
  永野広海
- Organizer
  第３１回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  倉敷市
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] PC 経皮免疫による粘膜免疫応答の誘導2013
- Author(s)
  永野広海
- Organizer
  第31回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  倉敷
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] PC経皮免疫による粘膜免疫応答の誘導2012
- Author(s)
  永野広海
- Organizer
  第１０回日本ワクチン学会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] Transcutaneous immunization with cholera toxin in BALB/c mice2012
- Author(s)
  H.Nagano
- Organizer
  The 14th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] コレラトキシン経皮免疫による粘膜免疫応答の誘導2012
- Author(s)
  永野広海
- Organizer
  第30回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大津市
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] Transcutaneous immunization with cholera toxin in BALB/C mice.2012
- Author(s)
  H. Nagano
- Organizer
  he 14thJapan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] PC 経皮免疫による粘膜免疫応答の誘導2012
- Author(s)
  永野広海
- Organizer
  第10回日本ワクチン学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] Phosphorylcholineを用いた経皮免疫について2011
- Author(s)
  永野広海
- Organizer
  第26回九州連合地方部会学術講演会
- Place of Presentation
  久留米市
- Year and Date
  2011-07-10
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] コレラトキシン経皮免疫による口腔粘膜免疫応答の誘導2011
- Author(s)
  永野広海
- Organizer
  第24回日本口腔・咽頭科学会総会学術講演会
- Place of Presentation
  広島市
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-22591911
[Presentation] ヒアルロン酸マイクロニードルを用いた経皮免疫
- Author(s)
  永野広海
- Organizer
  第３３回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  東京（東武ホテルレバント東京）
- Year and Date
  2015-02-26 – 2015-02-28
- Data Source
  KAKENHI-PROJECT-25861572
[Presentation] ヒアルロン酸マイクロニードルを用いた経皮免疫
- Author(s)
  永野広海
- Organizer
  第33回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  東京(東武ホテルレバント東京)
- Year and Date
  2015-02-26 – 2015-02-28
- Data Source
  KAKENHI-PROJECT-25462689

1. KURONO Yuichi (80153427)

# of Collaborated Projects: 7 results

# of Collaborated Products: 4 results
2. MIYASHITA Keiichi (30585063)

# of Collaborated Projects: 7 results

# of Collaborated Products: 3 results
3. 大堀純一郎 (90507162)

# of Collaborated Projects: 7 results

# of Collaborated Products: 4 results
4. KAWABATA MASAKI (30585112)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
5. MAKISE Takao (30585120)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. MASEDA Yoshiko (70535666)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 地村友宏 (10709596)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
8. 山下勝 (10635519)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
9. 田淵みな子 (90838187)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 井内寛之 (90645285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 宮之原郁代 (40305131)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MATSUNE Shoji (00253899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 原田みずえ (20585103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 馬越瑞夫 (30596325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 丸山征郎 (20082282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 内匠浩二 (50535820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 長野広明 (70778282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 中之薗良太 (00985088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 上村清央 (30593652)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岩永崇 (40444830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 大塚洋和 (40973699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 田畑和宏 (80419655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 吉浦敬 (40322747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAGANO Hiromi 永野 広海

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Co-Researchers

経皮感作が鼻副鼻腔アレルギー性疾患の発症に関与するメカニズムの解明と予防法を探索Principal Investigator

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Intranasolacrimal immunization for induction of secretory IgA responses in the respiratory tract.Principal Investigator

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Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responsesPrincipal Investigator

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Transcutaneous immunization with phosphorylcholine induces antigen-specific mucosal and systemic immune responses in BALB/c micePrincipal Investigator

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[Journal Article] Intranasolacrimal Immunization of Mice with Pneumococcal Surface Protein A Plus Poly(I:C) Protective Against Nasopharyngeal Carriage of Streptococcus pneumonia2023

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Journal Title

Data Source

[Journal Article] Intranasal immunization with phosphorylcholine suppresses allergic rhinitis in mice2018

Author(s)

Journal Title

NAGANO Hiromi 永野広海