SHINGAKI Tomotaka 新垣友隆

Researcher Number	60643187
Affiliation (based on the past Project Information) *help	2015 – 2016: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員 2013 – 2014: 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員
Review Section/Research Field	Principal Investigator Physical pharmacy Except Principal Investigator Neurophysiology / General neuroscience / Medical pharmacy
Keywords	Principal Investigator 製剤 / 製剤学 / 薬物動態学的解析 / DDS / 経鼻吸収 / PET Except Principal Investigator ＰＥＴ / 心と脳 / 痛み / オピオイド … More / 小動物脳機能画像解析 / プラセボ / Opioid / PET / Neuroimaging / Pain / Placebo / フェノタイピング / バーチャルクリニカルスタディ / 個人間変動 / 生理学的薬物速度論モデル / トランスポーター / 創薬支援システム / PET/SPECTプローブ / モデリング＆シミュレーション / 遺伝子多型 / 薬物間相互作用 / 薬物代謝酵素 / 薬物トランスポーター Less

Small-animal neuroimaging analysis of placebo analgesia
- Principal Investigator
  
  CUI Yilong
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Institute of Physical and Chemical Research
The Analysis on Nasal Drug Absorption Using Positron Emission TomographyPrincipal Investigator
- Principal Investigator
  
  SHINGAKI Tomotaka
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
Development of quantitative prediction methods for alteration in pharmacokinetics caused by interindividual variability in transporter function and transporter-mediated drug-drug interaction
- Principal Investigator
  
  Sugiyama Yuichi
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Medical pharmacy
- Research Institution
  Institute of Physical and Chemical Research

All 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Extension of recovery time from fatigue by repeated rest with short-term sleep during continuous fatigue load: Development of chronic fatigue model.2016
- Author(s)
  Kanzaki, A., Okauchi, T., Hu, D., Shingaki, T., Katayama, Y., Koyama, H., Watanabe, Y., and Cui Y.L.
- Journal Title
  
  J Neurosci Res
  
  Volume: 94 Issue: 5 Pages: 424-429
- DOI
  10.1002/jnr.23718
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14328, KAKENHI-PROJECT-15H02502, KAKENHI-PROJECT-26461371
[Journal Article] Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C] Metformin in Mouse.2015
- Author(s)
  Shingaki T, Hume WE, Takashima T, Katayama Y, Okauchi T, Hayashinaka E, Wada Y, Cui Y, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  Pharm Res
  
  Volume: 32 Pages: 2538-2547
- DOI
  10.1007/s11095-015-1642-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography tracer [11C]dehydropravastatin in rats.2013
- Author(s)
  Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui Y, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 347 Issue: 1 Pages: 193-202
- DOI
  10.1124/jpet.113.206425
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659574, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo.2013
- Author(s)
  Hume WE, Shingaki T, Takashima T, Hashizume Y, Okauchi T, Katayama Y, Hayashinaka E, Wada Y, Kusuhara H, Sugiyama Y and Watanabe Y.
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 21 Issue: 24 Pages: 7584-7590
- DOI
  10.1016/j.bmc.2013.10.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Journal Article] Dynamic analysis of GI absorption and hepatic distribution processes of telmisartan in rats using positron emission tomography.2012
- Author(s)
  Kataoka M, Takashima T, Shingaki T, Hashidzume Y, Katayama Y, Wada Y, Oh H, Masaoka Y, Sakuma S, Sugiyama Y, Yamashita S, Watanabe Y.
- Journal Title
  
  Pharm Res
  
  Volume: 29 Issue: 9 Pages: 2419-31
- DOI
  10.1007/s11095-012-0768-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 創薬と臨床開発の新時代を見据えたPETによる医薬品候補化合物の薬物動態評価.2015
- Author(s)
  新垣友隆, 崔翼龍, 渡邊恭良.
- Organizer
  第29 回日本医学会総会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-04-11
- Invited
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 創薬と臨床開発の新時代を見据えたPETによる医薬品候補化合物の薬物動態評価.2015
- Author(s)
  新垣友隆, 崔翼龍, 渡邊恭良.
- Organizer
  第29回日本医学会総会2015関西
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-04-11
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] 分子イメージング技術を用いた創薬における医薬品・化学物質の代謝・排泄機構の解析2014
- Author(s)
  新垣友隆、渡辺恭良
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市黒髪キャンパスエリア（北地区）全学教育棟 U会場
- Invited
- Data Source
  KAKENHI-PROJECT-25860036
[Presentation] PET分子イメージング技術を用いた薬物動態解析手法の開発2013
- Author(s)
  Tomotaka Shingaki and Yasuyoshi Watanabe
- Organizer
  BioJapan2013 World Business Forum
- Place of Presentation
  横浜市パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25860036
[Presentation] Positron Emission Tomography (PET)による経鼻吸収評価系の確立2013
- Author(s)
  新垣友隆、片山由美子、岡内隆、林中恵美、和田康弘、古林呂之、坂根稔康、崔翼龍、渡辺恭良
- Organizer
  第8回日本分子イメージング学会総会
- Place of Presentation
  横浜市横浜赤レンガ倉庫1号館
- Data Source
  KAKENHI-PROJECT-25860036
[Presentation] Molecular Imaging for Pharmacokinetics2013
- Author(s)
  Tomotaka Shingaki, Tadayuki Takashima, and Yasuyoshi Watanabe
- Organizer
  10th International ISSX Meeting
- Place of Presentation
  Toronto, Canada
- Invited
- Data Source
  KAKENHI-PROJECT-25860036
[Presentation] 経鼻投与を用いた薬物送達法の評価に対するPositron Emission Tomography (PET)の活用2013
- Author(s)
  新垣友隆、片山由美子、岡内隆、林中恵美、和田康弘、古林呂之、坂根稔康、崔翼龍、渡辺恭良
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都市京都テルサ
- Data Source
  KAKENHI-PROJECT-25860036
[Presentation] PETを用いた鼻腔内投与後の薬物動態と直接的脳移行の可視化
- Author(s)
  新垣友隆、古林呂之、坂根稔康、崔翼龍、渡辺恭良
- Organizer
  日本薬学会第135年会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-03-26 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-25860036
[Presentation] Translational Clinical Research of OATPs and MRP2 Activity Using Positron Emission Tomography (PET) with 11C-Dehydropravastatin.
- Author(s)
  Shingaki T, Tanaka M, Ishii A, Katayama Y, Tazawa S, Wada Y, Cui Y, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y
- Organizer
  World Molecular Imaging Congress 2014
- Place of Presentation
  Soul, Korea
- Year and Date
  2014-09-17 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] CLINICAL EVALUATION OF OATPs AND MRP2 ACTIVITY USING POSITRON EMISSION TOMOGRAPHY (PET) WITH [11C]DEHYDROPRAVASTATIN
- Author(s)
  Shingaki T, Tanaka M, Ishii A, Katayama Y, Tazawa S, Wada Y, Cui Y, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y
- Organizer
  19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  California, US
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-24229002
[Presentation] Positron Emission Tomography study on the Nasal Drug Absorption and Drug Delivery to the Brain
- Author(s)
  Tomotaka Shingaki, Yumiko Katayama, Takashi Okauchi, Emi Hayashinaka, Yasuhiro Wada, Tomoyuki Furubayashi, Yilong Cui, Toshiyasu Sakane, and Yasuyoshi Watanabe
- Organizer
  2014 AAPS Annual Meeting and Exposition
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2014-11-02 – 2014-11-04
- Data Source
  KAKENHI-PROJECT-25860036
[Presentation] Positron Emission Tomography (PET) を用いた経鼻吸収評価系の構築と脳への直接移行性に関する研究
- Author(s)
  新垣友隆、片山由美子、和田康弘、崔翼龍、古林呂之、坂根稔康、渡辺恭良
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  埼玉県さいたま市
- Year and Date
  2014-05-20 – 2014-05-22
- Data Source
  KAKENHI-PROJECT-25860036
[Presentation] The Analysis on Nasal Drug Absorption Using Positron Emission Tomography: The Pharmacokinetic Investigation and the Possibility of the Direct Drug Transport to the Brain
- Author(s)
  Tomotaka Shingaki, Yumiko Katayama, Takashi Okauchi, Emi Hayashinaka, Yasuhiro Wada, Tomoyuki Furubayashi, Yilong Cui, Toshiyasu Sakane, and Yasuyoshi Watanabe
- Organizer
  5th FIP Pharmaceutical Sciences World Congress
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2014-04-13 – 2014-04-16
- Data Source
  KAKENHI-PROJECT-25860036

1. Sugiyama Yuichi (80090471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. CUI Yilong (60312229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. Okauchi Takashi (80415405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 前田和哉 (00345258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 渡邊恭良 (40144399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 家入一郎 (60253473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 吉門崇 (70535096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 伊藤澄人 (20728969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小林真之 (00300830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FURUBAYASHI Tomoyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. SAKANE Toshiyasu

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. 渡辺恭良

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
13. 楠原洋之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHINGAKI Tomotaka 新垣 友隆

Research Projects

Research Products

Co-Researchers

Small-animal neuroimaging analysis of placebo analgesia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Analysis on Nasal Drug Absorption Using Positron Emission TomographyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of quantitative prediction methods for alteration in pharmacokinetics caused by interindividual variability in transporter function and transporter-mediated drug-drug interaction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Extension of recovery time from fatigue by repeated rest with short-term sleep during continuous fatigue load: Development of chronic fatigue model.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative Evaluation of mMate1 Function Based on Minimally Invasive Measurement of Tissue Concentration Using PET with [(11)C] Metformin in Mouse.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography tracer [11C]dehydropravastatin in rats.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The synthesis and biodistribution of [(11)C]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamic analysis of GI absorption and hepatic distribution processes of telmisartan in rats using positron emission tomography.2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] 創薬と臨床開発の新時代を見据えたPETによる医薬品候補化合物の薬物動態評価.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 創薬と臨床開発の新時代を見据えたPETによる医薬品候補化合物の薬物動態評価.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 分子イメージング技術を用いた創薬における医薬品・化学物質の代謝・排泄機構の解析2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] PET分子イメージング技術を用いた薬物動態解析手法の開発2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Positron Emission Tomography (PET)による経鼻吸収評価系の確立2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Molecular Imaging for Pharmacokinetics2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 経鼻投与を用いた薬物送達法の評価に対するPositron Emission Tomography (PET)の活用2013

SHINGAKI Tomotaka 新垣友隆