KAWABATA Tsuyoshi 川端剛

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Kawabata Tsuyoshi 川端剛

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Researcher Number	60734580
Other IDs	https://orcid.org/0000-0003-0899-0750
Affiliation (Current)	2025: 長崎大学, 原爆後障害医療研究所, 助教
Affiliation (based on the past Project Information) *help	2019 – 2023: 長崎大学, 原爆後障害医療研究所, 助教 2017: 長崎大学, 原爆後障害医療研究所, 助教 2016: 大阪大学, 医学系研究科, 特任助教(常勤) 2015: 大阪大学, 医学(系)研究科(研究院), 特任助教(常勤)
Review Section/Research Field	Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 49030:Experimental pathology-related / Laboratory animal science / Genetics/Chromosome dynamics Except Principal Investigator Basic Section 56030:Urology-related
Keywords	Principal Investigator オートファジー / ゲノム安定性の維持 / がん / ゲノム安定性 / 複製ストレス / リソソーム / mTOR / 飢餓 / イモリ / ゲノム情報の維持 … More / がん抑制遺伝子 / エピジェネティクス / ファンコニ経路 / 発がん / tandem-fluoresent tag / モデル動物 / in vivo測定 / タンデムタグ / Haloタグ / 測定系 / ガン / タンパク質凝集体 / DNA複製ストレス … More Except Principal Investigator マクロファジー / 低分子化合物ライブラリー / iPS細胞 / 脂質代謝異常 / マクロファージ / オートファジー / 尿路結石 Less

Determination of the mechanism and role of autophagy in starvation tolerance and tissue regeneration in newts.Principal Investigator
- Principal Investigator
  
  川端剛
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Nagasaki University
The role of autophagy in the maintenance of genomic stability and tumor suppressionPrincipal Investigator
- Principal Investigator
  
  Kawabata Tsuyoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Nagasaki University
Development and drug discovery for urolithiasis by integrated analysis of bio-repair mechanisms
- Principal Investigator
  
  Yasui Takahiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Nagoya City University
Establishment of a nobel method monitoring autophagy for in vivoPrincipal Investigator
- Principal Investigator
  
  KAWABATA Tsuyoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Nagasaki University
  Osaka University
Determination of a role for autophagy in suppression of genome instability caused by replication stressPrincipal Investigator
- Principal Investigator
  
  KAWABATA Tsuyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  Nagasaki University
  Osaka University

All 2022 2021 2020 2019 2017 2016 2015

All Journal Article Presentation

[Journal Article] Loss of RUBCN/rubicon in adipocytes mediates the upregulation of autophagy to promote the fasting response2022
- Author(s)
  Yamamuro Tadashi、Nakamura Shuhei、Yanagawa Kyosuke、Tokumura Ayaka、Kawabata Tsuyoshi、Fukuhara Atsunori、Teranishi Hirofumi、Hamasaki Maho、Shimomura Iichiro、Yoshimori Tamotsu
- Journal Title
  
  Autophagy
  
  Volume: - Issue: 11 Pages: 1-11
- DOI
  10.1080/15548627.2022.2047341
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22429, KAKENHI-PUBLICLY-20H05329, KAKENHI-PLANNED-21H05145, KAKENHI-PROJECT-19H03454, KAKENHI-PROJECT-21K06152, KAKENHI-PROJECT-20K08905
[Journal Article] Degradation of the Notch intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis.2022
- Author(s)
  Gota Yoshida, Tsuyoshi Kawabata, Hyota Takamutsu, Shotaro Saita, Shuhei Nakamura, Keizo Nishikawa, Mari Fujiwara, Yusuke Enokidani, Tadashi Yamamuro, Keisuke Tabata, Maho Hamasaki, Masaru Ishii, Atsushi Kumanogoh and Tamotsu Yoshimori
- Journal Title
  
  Autophagy
  
  Volume: 13 Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03454
[Journal Article] Autophagy Protects Integrity of Tumor Suppressors From Replication Stress2022
- Author(s)
  Tsuyoshi Kawabata, Rei Unno, Tadashi Yamamuro, Shun Kageyama, Kanako Akamatsu, Reiko Sekiya, Toshiharu Fujita, Maiko Sakamoto, Miho Kawakatsu, Maho Hamasaki, Shinji Goto, Shuhei Nakamura, Wataru Sakai, Norisato Mitsutake, Tao-Sheng Li, Yoshinobu Ichimura, Takahiro Yasui, Masaaki Komatsu, Tamotsu Yoshimori
- Journal Title
  
  Sneak Peak
  
  Volume: -
- DOI
  10.2139/ssrn.3950748
- Open Access
- Data Source
  KAKENHI-PROJECT-19H03454
[Journal Article] Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function2021
- Author(s)
  Yamamuro Tadashi et al.,
- Journal Title
  
  PLOS Genetics
  
  Volume: 17 Issue: 8 Pages: e1009688-e1009688
- DOI
  10.1371/journal.pgen.1009688
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22429, KAKENHI-PUBLICLY-20H05329, KAKENHI-PROJECT-19H03454, KAKENHI-PROJECT-21K06152
[Journal Article] Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy2020
- Author(s)
  Yamamuro Tadashi、Kawabata Tsuyoshi、Fukuhara Atsunori、Saita Shotaro、Nakamura Shuhei、Takeshita Hikari、Fujiwara Mari、Enokidani Yusuke、Yoshida Gota、Tabata Keisuke、Hamasaki Maho、Kuma Akiko、Yamamoto Koichi、Shimomura Iichiro、Yoshimori Tamotsu
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 4150-4150
- DOI
  10.1038/s41467-020-17985-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22429, KAKENHI-PROJECT-19H03454
[Journal Article] Autophagosome biogenesis and human health2020
- Author(s)
  Kawabata Tsuyoshi、Yoshimori Tamotsu
- Journal Title
  
  Cell Discovery
  
  Volume: 6 Issue: 1
- DOI
  10.1038/s41421-020-0166-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03454
[Journal Article] Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development2019
- Author(s)
  Unno Rei, Kawabata Tsuyoshi, Taguchi Kazumi, Sugino Teruaki, Hamamoto Shuzo, Ando Ryosuke, Okada Atsushi, Kohri Kenjiro, Yoshimori Tamotsu, Yasui Takahiro
- Journal Title
  
  Autophagy
  
  Volume: E-pub Issue: 4 Pages: 709-723
- DOI
  10.1080/15548627.2019.1635382
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09143, KAKENHI-PROJECT-19K09677, KAKENHI-PROJECT-19H03454, KAKENHI-PROJECT-19H03791, KAKENHI-PROJECT-17K11189, KAKENHI-PROJECT-19K18616
[Presentation] オートファジーの異常と複製ストレスに起因するゲノム情報の破綻2019
- Author(s)
  川端剛
- Organizer
  第42回　日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03454
[Presentation] Deregulated mTOR is responsible for autophagy defect exacerbating kidney stone development.2019
- Author(s)
  3.Unno Rei, Kawabata Tsuyoshi, Takase Hiroshi, Sugino Teruaki, Tanaka Yutaro, Unno Naoko, Fujii Yasuhiro, Taguchi Kazumi, Hamamoto Shuzo, Ando Ryosuke, Okada Atsushi, Kamiya Hiroyuki, Yasui Takahiro
- Organizer
  American Urological Association Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03791
[Presentation] オートファジーは複製ストレスに由来するゲノム不安定性を抑制する2017
- Author(s)
  川端剛、Tao-Sheng Li、吉森保
- Organizer
  第24回DNA複製・組換え修復ワークショップ
- Data Source
  KAKENHI-PROJECT-15H05601
[Presentation] Replication Stress-Induced Autophagy Promotes Chromosomal Stability2016
- Author(s)
  Tsuyoshi Kawabata, Kanako Akamatsu, Tamotsu Yoshimori
- Organizer
  2016 International A3 Foresight Symposium on Autophagy
- Place of Presentation
  Daejeou, Korea
- Year and Date
  2016-02-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05601
[Presentation] PIKKsによるオートファジー制御機構の解析2015
- Author(s)
  川端剛、吉森保
- Organizer
  第24回日本Cell Death学会学術集会
- Place of Presentation
  大阪、日本
- Year and Date
  2015-07-11
- Data Source
  KAKENHI-PROJECT-15H05601

1. Yasui Takahiro (40326153)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 海野怜 (40755683)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 田口和己 (00595184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 安藤亮介 (30381867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 松永民秀 (40209581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 岡田淳志 (70444966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 濱本周造 (80551267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 林利憲 (60580925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中村修平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 郡健二郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWABATA Tsuyoshi 川端 剛

Kawabata Tsuyoshi 川端 剛

Research Projects

Research Products

Co-Researchers

Determination of the mechanism and role of autophagy in starvation tolerance and tissue regeneration in newts.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of autophagy in the maintenance of genomic stability and tumor suppressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development and drug discovery for urolithiasis by integrated analysis of bio-repair mechanisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of a nobel method monitoring autophagy for in vivoPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Determination of a role for autophagy in suppression of genome instability caused by replication stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Loss of RUBCN/rubicon in adipocytes mediates the upregulation of autophagy to promote the fasting response2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Degradation of the Notch intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis.2022

Author(s)

Journal Title

Data Source

[Journal Article] Autophagy Protects Integrity of Tumor Suppressors From Replication Stress2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Autophagosome biogenesis and human health2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] オートファジーの異常と複製ストレスに起因するゲノム情報の破綻2019

Author(s)

Organizer

Data Source

[Presentation] Deregulated mTOR is responsible for autophagy defect exacerbating kidney stone development.2019

Author(s)

Organizer

Data Source

[Presentation] オートファジーは複製ストレスに由来するゲノム不安定性を抑制する2017

Author(s)

Organizer

KAWABATA Tsuyoshi 川端剛

Kawabata Tsuyoshi 川端剛