URATA Yoshishige 浦田芳重

… Alternative Names

浦田芳重ウラタヨシシゲ

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Researcher Number	30185087
Other IDs
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Affiliation (Current)	2025: 長崎大学, 原爆後障害医療研究所, 特任研究員
Affiliation (based on the past Project Information) *help	2022 – 2024: 長崎大学, 原爆後障害医療研究所, 特任研究員 2016 – 2019: 長崎大学, 医歯薬学総合研究科(医学系), 助教 2016: 長崎大学, 医歯薬学総合研究科, 助教 2014 – 2016: 長崎大学, 原爆後障害医療研究所, 助教 2012: 長崎大学, 医歯(薬)学総合研究科, 助教 … More 2012: 長崎大学, 医歯薬学総合研究科, 助教 2010 – 2011: 長崎大学, 大学院・医歯薬学総合研究科, 助教 2009: 長崎大学, 大学院・医歯薬学研究科, 助教 2003 – 2004: 長崎大学, 大学院・医歯薬学総合研究科, 助手 2000 – 2001: 長崎大学, 医学部, 助手 1997 – 1998: 長崎大学, 医学部, 助手 1986 – 1992: 長崎大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 52040:Radiological sciences-related / Risk sciences of radiation/Chemicals Except Principal Investigator 代謝生物化学 / Pathological medical chemistry / Radiation science / Basic Section 52040:Radiological sciences-related / Cardiovascular medicine / Circulatory organs internal medicine
Keywords	Principal Investigator γ-GCS / p53 / Akt / GST / 2 / ERK1 / activator protein-1 / ROR / RZR / VEGF … More / グルタチオン / 癌関連線維芽細胞 / エクソソーム / 放射線治療抵抗性 / 血管内皮増殖因子 / メラトニン / gamma-Glutamylcysteine synthetase / NF-kB / Glutathione / トランスフェクション / ルシフェラーゼ / γ-グルタミルシステインシンセターゼ / γ-グルタミルシステインシンテターゼ / NF-κB / ELISA / エピトープ / 自己抗原 / 自己免疫疾患 / ジヒドロリポアミドアセチル転移酵素 / 原発性胆汁性肝硬変症 … More Except Principal Investigator ピルビン酸脱水素酵素 / 塩基配列 / ミトコンドリア / アミノ酸配列 / クローニング / cDNA / mRNA / 遺伝子 / PDHbeta gene / PDHalpha gene / TATA box / CAAT box / α, βcDNA / α, βサブユニット / 放射線 / 酸化ストレス / ミトコンドリア代謝 / ミトコンドリア機能 / 幹細胞傷害 / 低線量率放射線 / 幹細胞機能 / 放射線影響 / 前転移ニッチ / 癌転移 / 放射線治療 / 副作用 / 転移 / 癌 / nucleotide sequences / biosynthesis / PDHalpha, beta mRNAs / PDHalpha, beta cDNAs / alpha_2beta_2 subunit structure / pyruvate dehydrogenase (PDH) / 機能発現 / 構造形成 / 生合成 / ヒト / Colony Hybridization / <lambda>gt11 Expression Screening / Thiamin Pyrophosphate-dependent Enzyme / 遺伝子(cDNA) / 攻α,β家兎抗体 / 【α_2】【β_2】構造 / α, βゲノムDNA / α, βmRNA / Amino Acid Sequences / Nucleotide Sequence / Cloning / Dihydrolipoamide Acyl-transferase / 前駆体の局在化 / リポ酸アシル基転移酵素 / Point mutation / PCR-amplification / Deficiency / Expression / Gene / alpha and beta subunits / Pyruvate dehydrogenase / 変異(欠損症)遺伝子 / βーサブユニット遺伝子 / αーサブユニット遺伝子 / ヒトピルビン酸脱水素酵素 / 点変異 / PCR増幅 / 欠損症 / 発現調節 / α,βサブユニット / Pyruvate dehydrogenase deficiency / Transcription start point / Pyruvate dehydrogenase (PDH) / ピルビン酸脱水素酵素欠損症 / 転写開始点 / βサブユニット / αサブユニット / 点突然変異プライマー / リン酸化部位 / リン酸化共有修飾 / クエン酸回路酵素 / 肺高血圧 / 肺高血圧症 / 再生修復機能 / 心臓幹細胞 / 心筋幹細胞 / 放射線傷害 / 非がん疾患リスク / 幹細胞 / アポ蛋白B / グルタチオン / 動脈硬化 / 臨床心血管病態学 / トランスフェラ-ゼ / エピト-プ領域 / ジヒドロリポアミドスクシニル / ジヒドロリポアミドアセチルトランスフェラ-ゼ / 自己免疫疾患 / 原発性胆汁性肝硬変症 Less

Molecular and cellular mechanisms about the acquired radioresistance in cancerPrincipal Investigator
- Principal Investigator
  
  浦田芳重
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Nagasaki University
Evaluating the biological effects of low-dose radiation based on the changes of tissue stem cells and mitochondrial metabolism
- Principal Investigator
  
  李桃生
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Nagasaki University
Development of drug that both reduce radiation treatment side effects and suppress cancer metastasis
- Principal Investigator
  
  LI Tao-Sheng
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
Radiation-induced injury in tissue-specific stem cells for evaluating non-cancer disease risks
- Principal Investigator
  
  LI Tao-Sheng
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
Exploratory study of novel oxidative stress markers for early diagnosis of pulmonary hypertension
- Principal Investigator
  
  IKEDA Satoshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Nagasaki University
The development and clinical application of a new oxidative stress marker using glutathionylated protein
- Principal Investigator
  
  IKEDA Satoshi
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagasaki University
Effect of nuclear glutathione on DNA damage by irradiationPrincipal Investigator
- Principal Investigator
  
  URATA Yoshishige
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagasaki University
The effect of melatonin on the cell proliferationPrincipal Investigator
- Principal Investigator
  
  URATA Yoshishige
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
The regulation of glutathione synthesis by oxidative stressesPrincipal Investigator
- Principal Investigator
  
  URATA Yoshishige
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
原発性胆汁性肝硬変症の自己抗原のエピトープ解析と臨床応用Principal Investigator
- Principal Investigator
  
  浦田芳重
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Institution
  Nagasaki University
Pyruvate Dehydrogenase Gene: Regulation of its Expression and Identification of Mutation in the PCR-amplified Exon Segments from the Patient with Fatal Deficiency
- Principal Investigator
  
  KOIKE Kichiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Nagasaki University
原発性胆汁性肝硬変症の発症機序解析と簡易診断法の開発
- Principal Investigator
  
  KOIKE Masahiko
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
Structure, Expression and Pathogenesis of Human Pyruvate Dehydrogenase Gene
- Principal Investigator
  
  KOIKE Kichiko
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
Genetic control of biosynthesis, structural assembly and activity expression of eukaryotic pyruvate dehydrogenase
- Principal Investigator
  
  KOIKE Masahiko
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Nagasaki University
クエン酸回路酵素のリン酸化共有修飾による活性制御とATP産生応答の遺伝子調節
- Principal Investigator
  
  小池正彦
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagasaki University
Primary and Gene Structures and Defect of Pyruvate Dehydrogenase (Thiamin pyrophosphate enzyme)
- Principal Investigator
  
  KOIKE Kichiko
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
Cloning and expression of dihydrolipoamide acyl-transferase gene and localization of its product in mitochondria
- Principal Investigator
  
  KOIKE Masahiko
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  代謝生物化学
- Research Institution
  Nagasaki University

All 2019 2018 2017 2016 2015 2014 2011 2010 Other

All Journal Article Presentation

[Journal Article] Immunomodulatory effect of mesenchymal stem cells: Cell origin and cell quality variations2019
- Author(s)
  El-Sayed Marwa、El-Feky Mohamed Ali、El-Amir Mostafa I.、Hasan Al Shaimaa、Tag-Adeen Mohammed、Urata Yoshishige、Goto Shinji、Luo Lan、Yan Chen、Li Tao-Sheng
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 46 Issue: 1 Pages: 1157-1165
- DOI
  10.1007/s11033-018-04582-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04265
[Journal Article] Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment2018
- Author(s)
  Yan Chen、Luo Lan、Urata Yoshishige、Goto Shinji、Li Tao-Sheng
- Journal Title
  
  Cancer Letters
  
  Volume: 418 Pages: 204-210
- DOI
  10.1016/j.canlet.2018.01.037
- NAID
  120006988061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17F17425, KAKENHI-PROJECT-17H04265
[Journal Article] Ionizing radiation impairs endogenous regeneration of infarcted heart: an in vivo 18F-FDG PET/CT and 99mTc-tetrofosmin SPECT/CT study in mice.2017
- Author(s)
  Luo L, Nishi K, Urata Y, Yan C, Hasan AS, Goto S, Kudo T, Li ZL, Li TS
- Journal Title
  
  Radiation Research
  
  Volume: 187 Issue: 1 Pages: 89-97
- DOI
  10.1667/rr14543.1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-26293279, KAKENHI-PROJECT-26461857, KAKENHI-PROJECT-17K10447, KAKENHI-PROJECT-15K15509
[Journal Article] Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice.2017
- Author(s)
  Luo L, Yan C, Urata Y, Hasan AS, Goto S, Guo CY, Zhang S, Li TS
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 40959-40959
- DOI
  10.1038/srep40959
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-26293279
[Journal Article] Radiation exposure decreases the quantity and quality of cardiac stem cells in mice.2016
- Author(s)
  Luo L, Urata Y, Yan C, Hasan AS, Goto S, Guo CY, Tou FF, Xie Y, Li TS.
- Journal Title
  
  PLoS ONE
  
  Volume: 印刷中
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293279
[Journal Article] Time- and dose-dependent effects of total-body ionising radiation on muscle stem cells2015
- Author(s)
  Masuda S, Hisamatsu T, Seko S, Urata Y, Goto S, Li TS & Ono Y
- Journal Title
  
  Physiol Rep
  
  Volume: 3(4) Issue: 4 Pages: e12377-e12377
- DOI
  10.14814/phy2.12377
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25560338, KAKENHI-PROJECT-15K15509, KAKENHI-PROJECT-26293279, KAKENHI-PROJECT-15H02654
[Journal Article] Sensitivity and Dose Denpendency of Radiation-induced injury in hematopoietic Stem/Progenitor Cells in Mice2015
- Author(s)
  Chang-Ying Guo, Lan Luo, Yoshishige Urata, Shinji Goto, Wen-Jing Huang, Syu Takamura, Fumiko Hayashi, Hanako Doi, Yuriko Kitajima, Yusuke Ono, Tomoo Ogi, and Tao-Sheng Li
- Journal Title
  
  Sci. Rep.
  
  Volume: 5 Issue: 1 Pages: 8055-8055
- DOI
  10.1038/srep08055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25750154, KAKENHI-PROJECT-26293279
[Journal Article] The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures.2014
- Author(s)
  Ali H, Galal O, Urata Y, Goto S, Guo CY, Luo L, Abdelrahim E, Ono Y, Mostafa E, Li TS.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 452 Issue: 3 Pages: 548-553
- DOI
  10.1016/j.bbrc.2014.08.112
- NAID
  120006986388
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293279
[Journal Article] Negatively charged low-density lipoprotein is associated with atherogenic risk in hypertensive patients2011
- Author(s)
  Urata J, Ikeda S, Koga S, Nakata T, Yasunaga T, Sonoda K, Koide Y, Ashizawa N, Kohno S, Maemura K
- Journal Title
  
  Heart Vessels
  
  Volume: Epub Apr 14 Issue: 3 Pages: 235-242
- DOI
  10.1007/s00380-011-0139-z
- NAID
  120006985130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390244, KAKENHI-PROJECT-21590902, KAKENHI-PROJECT-24390199, KAKENHI-PLANNED-22136007
[Presentation] The effects of nicaraven on the survival of cancer cells and the growth of established tumors after radiation exposure2017
- Author(s)
  Chen Yan, Lan Luo, Yoshishige Urata, Shinji Goto, Tao-Sheng Li
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-17H04265
[Presentation] Radiation-induced damages on cardiac stem cells and myocardial regeneration may indirectly indicate future cardiovascular disease risks2016
- Author(s)
  Lan Luo1, Kodai Nishi2, Yoshishige Urata, Chen Yan, Shinji Goto, Takashi Kudo, Tao-Sheng Li
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  JMSアステールプラザ（広島県・広島市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-26293279
[Presentation] 放射線被ばくによる心血管疾患リスクに関する実験的科学評価2015
- Author(s)
  羅蘭、浦田芳重、後藤信治、小野悠介、李桃生
- Organizer
  第５６回原子爆弾後障害研究会
- Place of Presentation
  広島国際会議場
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-26293279
[Presentation] Radiation-induced damage of cardiac stem cells in quantity and quality2015
- Author(s)
  Lan Luo, Yoshishige Urata, Shinji Goto, Yusuke Ono, Tao-Sheng Li
- Organizer
  ICRR2015 Kyoto Japan - 15th International Congress of Radiation Research
- Place of Presentation
  京都府京都市国際会議場
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293279
[Presentation] S-glutathionylated Apoprotein B100 is related with electronegativity of LDL in patients with atherogenic risks2011
- Author(s)
  Ikeda S, Koga S, Urata Y, Urata J, NakataT,Yasunaga T, Maemura K
- Organizer
  The 75th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Yokohama
- Year and Date
  2011-08-03
- Data Source
  KAKENHI-PROJECT-21590902
[Presentation] S-glutathionylated Apoprotein B100 is related with electronegativity of LDL in patients with atherogenic risks2011
- Author(s)
  Ikeda S, Koga S, Urata Y, Urata J, Nakata T, Yasunaga T, Maemura K
- Organizer
  The 75th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2011-08-03
- Data Source
  KAKENHI-PROJECT-21590902
[Presentation] 高血圧患者におけるAnion-exchange HPLCを用いた陰性荷電LDL分画の臨床的意義の検討2010
- Author(s)
  池田聡司、古賀聖士、浦田淳吾、安永智彦、中田智夫、前村浩二
- Organizer
  第58回日本心臓病学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21590902
[Presentation] Low-density lipoprotein subfractions isolated by anionexchange high-performance chromategraphy are associated with recent atherogenic risk factors in hypertensive patients2010
- Author(s)
  Ikeda S, Koga S, Urata J, Yasunaga T, Nakata T, Maemura K
- Organizer
  第42回日本動脈硬化学会・学術集会
- Place of Presentation
  岐阜
- Year and Date
  2010-07-16
- Data Source
  KAKENHI-PROJECT-21590902
[Presentation] Anion-exchange high performance liquid chromatographyを用いた陰性荷電LDLの臨床的意義の検討2010
- Author(s)
  池田聡司、古賀聖士、浦田淳吾、安永智彦、中田智夫、前村浩二
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-21590902
[Presentation] Is S-glutathionylated Apoprotein B100 a potential marker for atherogenic risk?2010
- Author(s)
  Ikeda S, Koga S, Urata Y, Urata J, Nakata T, Yasunaga T, Maemura K
- Organizer
  AHA Scientific Sessions 2010
- Place of Presentation
  Chicago, US
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-21590902
[Presentation] Radiation-induced damage of cardiac stem cells in quantity and quality
- Author(s)
  Lan Luo, Yoshishige Urata, Shinji Goto, Yusuke Ono, Tao-Sheng Li
- Organizer
  ＩＣＲＲ２０１５
- Place of Presentation
  京都国際会館
- Year and Date
  2015-05-25 – 2015-05-29
- Data Source
  KAKENHI-PROJECT-26293279

1. GOTO Sinji (50186889)

# of Collaborated Projects: 8 results

# of Collaborated Products: 8 results
2. KOIKE Masahiko (10039521)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. KOIKE Kichiko (80039619)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. LI Tao-Sheng (50379997)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
5. YANAGITA Yutaka (80191162)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. IKEDA Satoshi (10336159)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
7. MAEMURA Koji (90282649)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
8. KONDO Takahito (00158908)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. IHARA Yoshito (70263241)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 工藤崇 (20330300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 小野悠介 (60601119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. 西弘大 (10719496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 黄文敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. LUO LAN

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

URATA Yoshishige 浦田 芳重

浦田 芳重 ウラタ ヨシシゲ

Research Projects

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Co-Researchers

Molecular and cellular mechanisms about the acquired radioresistance in cancerPrincipal Investigator

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Effect of nuclear glutathione on DNA damage by irradiationPrincipal Investigator

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The effect of melatonin on the cell proliferationPrincipal Investigator

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The regulation of glutathione synthesis by oxidative stressesPrincipal Investigator

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原発性胆汁性肝硬変症の自己抗原のエピトープ解析と臨床応用Principal Investigator

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URATA Yoshishige 浦田芳重

浦田芳重ウラタヨシシゲ