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URATA Yoshishige  浦田 芳重

ORCIDConnect your ORCID iD *help
… Alternative Names

浦田 芳重  ウラタ ヨシシゲ

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Researcher Number 30185087
Other IDs
External Links
Affiliation (Current) 2022: 長崎大学, 原爆後障害医療研究所, 特任研究員
Affiliation (based on the past Project Information) *help 2022: 長崎大学, 原爆後障害医療研究所, 客員研究員
2016 – 2019: 長崎大学, 医歯薬学総合研究科(医学系), 助教
2016: 長崎大学, 医歯薬学総合研究科, 助教
2014 – 2016: 長崎大学, 原爆後障害医療研究所, 助教
2012: 長崎大学, 医歯(薬)学総合研究科, 助教 … More
2012: 長崎大学, 医歯薬学総合研究科, 助教
2010 – 2011: 長崎大学, 大学院・医歯薬学総合研究科, 助教
2009: 長崎大学, 大学院・医歯薬学研究科, 助教
2003 – 2004: 長崎大学, 大学院・医歯薬学総合研究科, 助手
2000 – 2001: 長崎大学, 医学部, 助手
1997 – 1998: 長崎大学, 医学部, 助手
1986 – 1992: 長崎大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / Risk sciences of radiation/Chemicals / Basic Section 52040:Radiological sciences-related
Except Principal Investigator
Pathological medical chemistry / 代謝生物化学 / Radiation science / Circulatory organs internal medicine / Cardiovascular medicine / Basic Section 52040:Radiological sciences-related
Keywords
Principal Investigator
γ-GCS / グルタチオン / VEGF / RZR / ROR / activator protein-1 / ERK1 / 2 / GST / Akt … More / p53 / 原発性胆汁性肝硬変症 / ジヒドロリポアミドアセチル転移酵素 / 自己免疫疾患 / 自己抗原 / エピトープ / ELISA / NF-κB / γ-グルタミルシステインシンテターゼ / γ-グルタミルシステインシンセターゼ / ルシフェラーゼ / トランスフェクション / Glutathione / NF-kB / gamma-Glutamylcysteine synthetase / メラトニン / 血管内皮増殖因子 / 放射線治療抵抗性 / エクソソーム / 癌関連線維芽細胞 … More
Except Principal Investigator
ピルビン酸脱水素酵素 / 塩基配列 / 酸化ストレス / 放射線 / α, βサブユニット / α, βcDNA / CAAT box / TATA box / PDHalpha gene / PDHbeta gene / 遺伝子 / mRNA / cDNA / クローニング / アミノ酸配列 / 原発性胆汁性肝硬変症 / 自己免疫疾患 / ジヒドロリポアミドアセチルトランスフェラ-ゼ / ジヒドロリポアミドスクシニル / エピト-プ領域 / トランスフェラ-ゼ / 臨床心血管病態学 / 動脈硬化 / グルタチオン / アポ蛋白B / 幹細胞 / 非がん疾患リスク / 放射線傷害 / 心筋幹細胞 / 心臓幹細胞 / 再生修復機能 / 肺高血圧症 / 肺高血圧 / クエン酸回路酵素 / リン酸化共有修飾 / リン酸化部位 / 点突然変異プライマー / αサブユニット / βサブユニット / 転写開始点 / ピルビン酸脱水素酵素欠損症 / Pyruvate dehydrogenase (PDH) / Transcription start point / Pyruvate dehydrogenase deficiency / α,βサブユニット / 発現調節 / 欠損症 / PCR増幅 / 点変異 / ヒトピルビン酸脱水素酵素 / αーサブユニット遺伝子 / βーサブユニット遺伝子 / 変異(欠損症)遺伝子 / Pyruvate dehydrogenase / alpha and beta subunits / Gene / Expression / Deficiency / PCR-amplification / Point mutation / リポ酸アシル基転移酵素 / 前駆体の局在化 / ミトコンドリア / Dihydrolipoamide Acyl-transferase / Cloning / Nucleotide Sequence / Amino Acid Sequences / α, βmRNA / α, βゲノムDNA / 【α_2】【β_2】構造 / 攻α,β家兎抗体 / 遺伝子(cDNA) / Thiamin Pyrophosphate-dependent Enzyme / <lambda>gt11 Expression Screening / Colony Hybridization / ヒト / 生合成 / 構造形成 / 機能発現 / pyruvate dehydrogenase (PDH) / alpha_2beta_2 subunit structure / PDHalpha, beta cDNAs / PDHalpha, beta mRNAs / biosynthesis / nucleotide sequences / 癌 / 転移 / 副作用 / 放射線治療 / 癌転移 / 前転移ニッチ / 放射線影響 / 幹細胞機能 / ミトコンドリア代謝 Less
  • Research Projects

    (17 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (14 People)
  •  Evaluating the biological effects of low-dose radiation based on the changes of tissue stem cells and mitochondrial metabolism

    • Principal Investigator
      李 桃生
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Nagasaki University
  •  Molecular and cellular mechanisms about the acquired radioresistance in cancerPrincipal Investigator

    • Principal Investigator
      浦田 芳重
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      Nagasaki University
  •  Development of drug that both reduce radiation treatment side effects and suppress cancer metastasis

    • Principal Investigator
      LI Tao-Sheng
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Nagasaki University
  •  Radiation-induced injury in tissue-specific stem cells for evaluating non-cancer disease risks

    • Principal Investigator
      LI Tao-Sheng
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Nagasaki University
  •  Exploratory study of novel oxidative stress markers for early diagnosis of pulmonary hypertension

    • Principal Investigator
      IKEDA Satoshi
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Nagasaki University
  •  The development and clinical application of a new oxidative stress marker using glutathionylated protein

    • Principal Investigator
      IKEDA Satoshi
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Nagasaki University
  •  Effect of nuclear glutathione on DNA damage by irradiationPrincipal Investigator

    • Principal Investigator
      URATA Yoshishige
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Nagasaki University
  •  The effect of melatonin on the cell proliferationPrincipal Investigator

    • Principal Investigator
      URATA Yoshishige
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  The regulation of glutathione synthesis by oxidative stressesPrincipal Investigator

    • Principal Investigator
      URATA Yoshishige
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  原発性胆汁性肝硬変症の自己抗原のエピトープ解析と臨床応用Principal Investigator

    • Principal Investigator
      浦田 芳重
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Institution
      Nagasaki University
  •  Pyruvate Dehydrogenase Gene: Regulation of its Expression and Identification of Mutation in the PCR-amplified Exon Segments from the Patient with Fatal Deficiency

    • Principal Investigator
      KOIKE Kichiko
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      代謝生物化学
    • Research Institution
      Nagasaki University
  •  原発性胆汁性肝硬変症の発症機序解析と簡易診断法の開発

    • Principal Investigator
      KOIKE Masahiko
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  Structure, Expression and Pathogenesis of Human Pyruvate Dehydrogenase Gene

    • Principal Investigator
      KOIKE Kichiko
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  Genetic control of biosynthesis, structural assembly and activity expression of eukaryotic pyruvate dehydrogenase

    • Principal Investigator
      KOIKE Masahiko
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      代謝生物化学
    • Research Institution
      Nagasaki University
  •  クエン酸回路酵素のリン酸化共有修飾による活性制御とATP産生応答の遺伝子調節

    • Principal Investigator
      小池 正彦
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagasaki University
  •  Primary and Gene Structures and Defect of Pyruvate Dehydrogenase (Thiamin pyrophosphate enzyme)

    • Principal Investigator
      KOIKE Kichiko
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Nagasaki University
  •  Cloning and expression of dihydrolipoamide acyl-transferase gene and localization of its product in mitochondria

    • Principal Investigator
      KOIKE Masahiko
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      代謝生物化学
    • Research Institution
      Nagasaki University

All 2019 2018 2017 2016 2015 2014 2012 2011 2010 Other

All Journal Article Presentation

  • [Journal Article] Immunomodulatory effect of mesenchymal stem cells: Cell origin and cell quality variations2019

    • Author(s)
      El-Sayed Marwa、El-Feky Mohamed Ali、El-Amir Mostafa I.、Hasan Al Shaimaa、Tag-Adeen Mohammed、Urata Yoshishige、Goto Shinji、Luo Lan、Yan Chen、Li Tao-Sheng
    • Journal Title

      Molecular Biology Reports

      Volume: 46 Pages: 1157-1165

    • DOI

      10.1007/s11033-018-04582-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04265
  • [Journal Article] Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment2018

    • Author(s)
      Yan Chen、Luo Lan、Urata Yoshishige、Goto Shinji、Li Tao-Sheng
    • Journal Title

      Cancer Letters

      Volume: 418 Pages: 204-210

    • DOI

      10.1016/j.canlet.2018.01.037

    • NAID

      120006988061

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17F17425, KAKENHI-PROJECT-17H04265
  • [Journal Article] Ionizing Radiation Impairs Endogenous Regeneration of Infarcted Heart: An In Vivo 18F-FDG PET/CT and 99mTc-Tetrofosmin SPECT/CT Study in Mice.2017

    • Author(s)
      Luo L, Nishi K, Urata Y, Yan C, Hasan AS, Goto S, Kudo T, Li ZL, Li TS
    • Journal Title

      Radiat Res

      Volume: 187 Pages: 89-97

    • DOI

      10.1667/rr14543.1

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-26293279, KAKENHI-PROJECT-26461857, KAKENHI-PROJECT-17K10447, KAKENHI-PROJECT-15K15509
  • [Journal Article] Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice.2017

    • Author(s)
      Luo L, Yan C, Urata Y, Hasan AS, Goto S, Guo CY, Zhang S, Li TS
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 40959-40959

    • DOI

      10.1038/srep40959

    • NAID

      120006987566

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-26293279
  • [Journal Article] Radiation exposure decreases the quantity and quality of cardiac stem cells in mice.2016

    • Author(s)
      Luo L, Urata Y, Yan C, Hasan AS, Goto S, Guo CY, Tou FF, Xie Y, Li TS.
    • Journal Title

      PLoS ONE

      Volume: 印刷中

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293279
  • [Journal Article] Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts.2015

    • Author(s)
      Masuda S, Hisamatsu T, Seko S, Urata Y, Goto S, Li TS & Ono Y
    • Journal Title

      Physiological Reports

      Volume: 3(4)

    • DOI

      10.14814/phy2.12377

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25560338, KAKENHI-PROJECT-15K15509, KAKENHI-PROJECT-26293279, KAKENHI-PROJECT-15H02654
  • [Journal Article] Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice.2015

    • Author(s)
      Chang-Ying Guo, Lan Luo, Yoshishige Urata, Shinji Goto, Wen-Jing Huang, Syu Takamura, Fumiko Hayashi, Hanako Doi, Yuriko Kitajima, Yusuke Ono, Tomoo Ogi, and Tao-Sheng Li
    • Journal Title

      Sci Rep.

      Volume: 5 Pages: 8055-8055

    • DOI

      10.1038/srep08055

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25750154, KAKENHI-PROJECT-26293279
  • [Journal Article] The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures.2014

    • Author(s)
      Ali H, Galal O, Urata Y, Goto S, Guo CY, Luo L, Abdelrahim E, Ono Y, Mostafa E, Li TS.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 452 Pages: 548-553

    • DOI

      10.1016/j.bbrc.2014.08.112

    • NAID

      120006986388

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293279
  • [Journal Article] Negatively charged low-density lipoprotein with atherogenic risk in hypertensive patients2012

    • Author(s)
      Urata J, Ikeda S, Koga S, Nakata T, Yasunaga T, Sonoda K, Koide Y, Ashizawa N, Kohno S, Maemura K
    • Journal Title

      Heart and Vessels

      Volume: Epub Apr 14 Pages: 235-242

    • DOI

      10.1007/s00380-011-0139-z

    • NAID

      120006985130

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390244, KAKENHI-PROJECT-21590902, KAKENHI-PROJECT-24390199, KAKENHI-PLANNED-22136007
  • [Presentation] The effects of nicaraven on the survival of cancer cells and the growth of established tumors after radiation exposure2017

    • Author(s)
      Chen Yan, Lan Luo, Yoshishige Urata, Shinji Goto, Tao-Sheng Li
    • Organizer
      日本癌学会
    • Data Source
      KAKENHI-PROJECT-17H04265
  • [Presentation] Radiation-induced damages on cardiac stem cells and myocardial regeneration may indirectly indicate future cardiovascular disease risks2016

    • Author(s)
      Lan Luo1, Kodai Nishi2, Yoshishige Urata, Chen Yan, Shinji Goto, Takashi Kudo, Tao-Sheng Li
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ(広島県・広島市)
    • Year and Date
      2016-10-26
    • Data Source
      KAKENHI-PROJECT-26293279
  • [Presentation] 放射線被ばくによる心血管疾患リスクに関する実験的科学評価2015

    • Author(s)
      羅蘭、浦田芳重、後藤信治、小野悠介、李桃生
    • Organizer
      第56回原子爆弾後障害研究会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2015-06-06
    • Data Source
      KAKENHI-PROJECT-26293279
  • [Presentation] Radiation-induced damage of cardiac stem cells in quantity and quality2015

    • Author(s)
      Lan Luo, Yoshishige Urata, Shinji Goto, Yusuke Ono, Tao-Sheng Li
    • Organizer
      ICRR2015 Kyoto Japan - 15th International Congress of Radiation Research
    • Place of Presentation
      京都府京都市国際会議場
    • Year and Date
      2015-05-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293279
  • [Presentation] S-glutathionylated Apoprotein B100 is related with electronegativity of LDL in patients with atherogenic risks2011

    • Author(s)
      Ikeda S, Koga S, Urata Y, Urata J, NakataT,Yasunaga T, Maemura K
    • Organizer
      The 75th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-08-03
    • Data Source
      KAKENHI-PROJECT-21590902
  • [Presentation] S-glutathionylated Apoprotein B100 is related with electronegativity of LDL in patients with atherogenic risks2011

    • Author(s)
      Ikeda S, Koga S, Urata Y, Urata J, Nakata T, Yasunaga T, Maemura K
    • Organizer
      The 75th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-08-03
    • Data Source
      KAKENHI-PROJECT-21590902
  • [Presentation] 高血圧患者におけるAnion-exchange HPLCを用いた陰性荷電LDL分画の臨床的意義の検討2010

    • Author(s)
      池田聡司、古賀聖士、浦田淳吾、安永智彦、中田智夫、前村浩二
    • Organizer
      第58回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-17
    • Data Source
      KAKENHI-PROJECT-21590902
  • [Presentation] Low-density lipoprotein subfractions isolated by anionexchange high-performance chromategraphy are associated with recent atherogenic risk factors in hypertensive patients2010

    • Author(s)
      Ikeda S, Koga S, Urata J, Yasunaga T, Nakata T, Maemura K
    • Organizer
      第42回日本動脈硬化学会・学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-07-16
    • Data Source
      KAKENHI-PROJECT-21590902
  • [Presentation] Anion-exchange high performance liquid chromatographyを用いた陰性荷電LDLの臨床的意義の検討2010

    • Author(s)
      池田聡司、古賀聖士、浦田淳吾、安永智彦、中田智夫、前村浩二
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-15
    • Data Source
      KAKENHI-PROJECT-21590902
  • [Presentation] Is S-glutathionylated Apoprotein B100 a potential marker for atherogenic risk?2010

    • Author(s)
      Ikeda S, Koga S, Urata Y, Urata J, Nakata T, Yasunaga T, Maemura K
    • Organizer
      AHA Scientific Sessions 2010
    • Place of Presentation
      Chicago, US
    • Year and Date
      2010-11-14
    • Data Source
      KAKENHI-PROJECT-21590902
  • [Presentation] Radiation-induced damage of cardiac stem cells in quantity and quality

    • Author(s)
      Lan Luo, Yoshishige Urata, Shinji Goto, Yusuke Ono, Tao-Sheng Li
    • Organizer
      ICRR2015
    • Place of Presentation
      京都国際会館
    • Year and Date
      2015-05-25 – 2015-05-29
    • Data Source
      KAKENHI-PROJECT-26293279
  • 1.  GOTO Sinji (50186889)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 13 results
  • 2.  KOIKE Masahiko (10039521)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 3.  KOIKE Kichiko (80039619)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 4.  LI Tao-Sheng (50379997)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 13 results
  • 5.  YANAGITA Yutaka (80191162)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  IKEDA Satoshi (10336159)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 7.  MAEMURA Koji (90282649)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 8.  KONDO Takahito (00158908)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  IHARA Yoshito (70263241)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  工藤 崇 (20330300)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  小野 悠介 (60601119)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 12.  西 弘大 (10719496)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  黄 文敬
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  LUO LAN
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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