GOTO Shinji 後藤信治

… Alternative Names

後藤信治ゴトウシンジ

GOTO Shinzi 後藤信治

GOTO Sinji 後藤信治

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Researcher Number	50186889
Other IDs
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Affiliation (Current)	2022: 長崎大学, 原爆後障害医療研究所, 助教
Affiliation (based on the past Project Information) *help	2021 – 2022: 長崎大学, 原爆後障害医療研究所, 助教 2013 – 2019: 長崎大学, 原爆後障害医療研究所, 助教 2003 – 2005: Nagasaki University, Graduate School of Biomedical Sciences, Research Associate, 大学院・医歯薬学総合研究科, 助手 2000 – 2002: 長崎大学, 医学部, 助手 1996: 長崎大学, 医学部, 助手 1991 – 1994: 長崎大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Digestive surgery / Respiratory organ internal medicine / General medical chemistry / Pathological medical chemistry / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related / 代謝生物化学 / Pathological medical chemistry / Risk sciences of radiation/Chemicals / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator glutathione S-transferase π / 癌 / 薬剤耐性 / グルタチオン / シスプラチン / がん幹細胞 / nuclear translocation / cisplatin / cancer / drug resistance … More / doxorubicin / oxidative stress / exocyclic DNA adducts / anti-cancer drug resistance / nucleus / 酵素 / 慢性肺気腫 / マンノース-6-リン酸 / alpha_1-アンチトリプシン / 好中球由来エラスターゼ / グルタチオン S-トランスフェラーゼπ / がん幹細胞マーカー / 抗がん剤耐性 / 栄養飢餓耐性 / グルタチオンS-トランスフェラーゼ / GSTπ / 核局在 / 大腸がん / deug resistance / doxoruvicin / glutathione S-transferaseπ / apoptosis / glutathione S-transferasen / nuclear localization signal / mitochondria import signal / mitochondria / CD133 / CD44 / 糖代謝 / ペントースリン酸回路 / グルコース飢餓 / 解糖系 / 代謝 / がん / ミトコンドリア / カルシウムイオン / エネルギー代謝 … More Except Principal Investigator γ-GCS / 放射線 / VEGF / RZR / ROR / activator protein-1 / ERK1 / 2 / GST / Akt / p53 / 原発性胆汁性肝硬変症 / ジヒドロリポアミドアセチル転移酵素 / 自己免疫疾患 / 自己抗原 / エピトープ / ELISA / 幹細胞 / 非がん疾患リスク / 放射線傷害 / 心筋幹細胞 / 心臓幹細胞 / 再生修復機能 / ピルビン酸脱水素酵素 / α,βサブユニット / 遺伝子 / 発現調節 / 欠損症 / PCR増幅 / 点変異 / ヒトピルビン酸脱水素酵素 / αーサブユニット遺伝子 / βーサブユニット遺伝子 / 変異(欠損症)遺伝子 / Pyruvate dehydrogenase / alpha and beta subunits / Gene / Expression / Deficiency / PCR-amplification / Point mutation / メラトニン / 血管内皮増殖因子 / グルタチオン / 癌 / 転移 / 副作用 / 放射線治療 / 癌転移 / 前転移ニッチ / 放射線影響 / 幹細胞機能 / ミトコンドリア代謝 / 放射線治療抵抗性 / エクソソーム / 癌関連線維芽細胞 / 再生 / エピジェネティック制御 / ヒストン修飾 / ストレス応答 / イモリ / マウス Less

Evaluating the biological effects of low-dose radiation based on the changes of tissue stem cells and mitochondrial metabolism
- Principal Investigator
  
  李桃生
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Nagasaki University
Molecular and cellular mechanisms about the acquired radioresistance in cancer
- Principal Investigator
  
  浦田芳重
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Nagasaki University
A new approach to cancer focusing on mitochondrial calciumPrincipal Investigator
- Principal Investigator
  
  後藤信治
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagasaki University
Epigenetic regulation as novel approach for organ regeneration - Learning from the stress response mechanism
- Principal Investigator
  
  李桃生
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Nagasaki University
Development of drug that both reduce radiation treatment side effects and suppress cancer metastasis
- Principal Investigator
  
  LI Tao-Sheng
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
Development of novel cancer therapeutics targeting metabolic characteristics of cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  GOTO Shinji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Nagasaki University
Radiation-induced injury in tissue-specific stem cells for evaluating non-cancer disease risks
- Principal Investigator
  
  LI Tao-Sheng
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Nagasaki University
The explore of new cancer stem cell marker based on intracellular behavior of biological defense factorPrincipal Investigator
- Principal Investigator
  
  GOTO Shinji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Nagasaki University
Molecular mechanism of intracellular localization of glutathione S-transferase πPrincipal Investigator
- Principal Investigator
  
  GOTO Shinji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
Effect of nuclear glutathione on DNA damage by irradiation
- Principal Investigator
  
  URATA Yoshishige
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Nagasaki University
Basic Research of Novel Molecular Target on Cancer ChemotherapyPrincipal Investigator
- Principal Investigator
  
  GOTO Shinji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
The effect of melatonin on the cell proliferation
- Principal Investigator
  
  URATA Yoshishige
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
細胞におけるグルタチオン-シスプラチン結合体の形成と排出機構の解明Principal Investigator
- Principal Investigator
  
  後藤信治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
ガン細胞のシスプラチン耐性獲得機構の解明Principal Investigator
- Principal Investigator
  
  後藤信治
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagasaki University
慢性肺気腫の膜受容体を介した新しい治療法の開発Principal Investigator
- Principal Investigator
  
  後藤信治
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nagasaki University
原発性胆汁性肝硬変症の自己抗原のエピトープ解析と臨床応用
- Principal Investigator
  
  URATA Yosisige
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Institution
  Nagasaki University
Pyruvate Dehydrogenase Gene: Regulation of its Expression and Identification of Mutation in the PCR-amplified Exon Segments from the Patient with Fatal Deficiency
- Principal Investigator
  
  KOIKE Kichiko
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Nagasaki University

All 2020 2019 2018 2017 2016 2015 2014 2013 2005 2004 Other

All Journal Article Presentation

[Journal Article] Nicaraven Attenuates Postoperative Systemic Inflammatory Responses-Induced Tumor Metastasis.2020
- Author(s)
  Zhang X, Moriwaki T, Kawabata T, Goto S, Liu KX, Guo CY, Li TS.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 27 Pages: 1068-1074
- DOI
  10.1245/s10434-019-08076-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04265
[Journal Article] Immunomodulatory effect of mesenchymal stem cells: Cell origin and cell quality variations2019
- Author(s)
  El-Sayed Marwa、El-Feky Mohamed Ali、El-Amir Mostafa I.、Hasan Al Shaimaa、Tag-Adeen Mohammed、Urata Yoshishige、Goto Shinji、Luo Lan、Yan Chen、Li Tao-Sheng
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 46 Pages: 1157-1165
- DOI
  10.1007/s11033-018-04582-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04265
[Journal Article] Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment2018
- Author(s)
  Yan Chen、Luo Lan、Urata Yoshishige、Goto Shinji、Li Tao-Sheng
- Journal Title
  
  Cancer Letters
  
  Volume: 418 Pages: 204-210
- DOI
  10.1016/j.canlet.2018.01.037
- NAID
  120006988061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17F17425, KAKENHI-PROJECT-17H04265
[Journal Article] Ionizing Radiation Impairs Endogenous Regeneration of Infarcted Heart: An In Vivo 18F-FDG PET/CT and 99mTc-Tetrofosmin SPECT/CT Study in Mice.2017
- Author(s)
  Luo L, Nishi K, Urata Y, Yan C, Hasan AS, Goto S, Kudo T, Li ZL, Li TS
- Journal Title
  
  Radiat Res
  
  Volume: 187 Pages: 89-97
- DOI
  10.1667/rr14543.1
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-26293279, KAKENHI-PROJECT-26461857, KAKENHI-PROJECT-17K10447, KAKENHI-PROJECT-15K15509
[Journal Article] Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice.2017
- Author(s)
  Luo L, Yan C, Urata Y, Hasan AS, Goto S, Guo CY, Zhang S, Li TS
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Pages: 40959-40959
- DOI
  10.1038/srep40959
- NAID
  120006987566
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02654, KAKENHI-PROJECT-26293279
[Journal Article] Radiation exposure decreases the quantity and quality of cardiac stem cells in mice.2016
- Author(s)
  Luo L, Urata Y, Yan C, Hasan AS, Goto S, Guo CY, Tou FF, Xie Y, Li TS.
- Journal Title
  
  PLoS ONE
  
  Volume: 印刷中
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293279
[Journal Article] Enhanced autophagy in colorectal cancer stem cells does not contribute to radio-resistance.2016
- Author(s)
  Chen Yan, Lan Luo, Shinji Goto, Yoshishige Urata, Chang-Ying Guo, Hanako Doi, Kaio Kitazato, Tao-Sheng Li
- Journal Title
  
  Oncotarget
  
  Volume: 印刷中 Pages: 45112-45121
- DOI
  10.18632/oncotarget.8972
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462061, KAKENHI-PROJECT-15H02654
[Journal Article] Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts.2015
- Author(s)
  Masuda S, Hisamatsu T, Seko S, Urata Y, Goto S, Li TS & Ono Y
- Journal Title
  
  Physiological Reports
  
  Volume: 3(4)
- DOI
  10.14814/phy2.12377
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25560338, KAKENHI-PROJECT-15K15509, KAKENHI-PROJECT-26293279, KAKENHI-PROJECT-15H02654
[Journal Article] Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice.2015
- Author(s)
  Chang-Ying Guo, Lan Luo, Yoshishige Urata, Shinji Goto, Wen-Jing Huang, Syu Takamura, Fumiko Hayashi, Hanako Doi, Yuriko Kitajima, Yusuke Ono, Tomoo Ogi, and Tao-Sheng Li
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Pages: 8055-8055
- DOI
  10.1038/srep08055
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25750154, KAKENHI-PROJECT-26293279
[Journal Article] The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures.2014
- Author(s)
  Ali H, Galal O, Urata Y, Goto S, Guo CY, Luo L, Abdelrahim E, Ono Y, Mostafa E, Li TS.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 452 Pages: 548-553
- DOI
  10.1016/j.bbrc.2014.08.112
- NAID
  120006986388
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293279
[Journal Article] Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice2013
- Author(s)
  Kawakatsu M, Urata Y, Imai R, Goto S, Ono Y, Nishida N, Li TS
- Journal Title
  
  PLoS One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0060023
- NAID
  120006985963
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462061
[Journal Article] Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity2013
- Author(s)
  Kawakatsu et al
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 54(2) Pages: 268-276
- DOI
  10.1093/jrr/rrs105
- NAID
  120006985982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24800051, KAKENHI-PROJECT-25462061
[Journal Article] Nuclear Localization of Glutathione S-Transferase π is an Evaluation Factor for Drug Resistance in Gynecological Cancers.2005
- Author(s)
  Soh, Y., Goto, S., et al.
- Journal Title
  
  Clinical Oncology (in press)
- Data Source
  KAKENHI-PROJECT-16590247
[Journal Article] Nuclear Localization of Glutathione S-Transferase π is an Evaluation Factor for Drug Resistance in Gynecological Cancers.2005
- Author(s)
  Soh, Y., Goto, S., Kitajima, M., Moriyama, S., Kotera, K., Nakayama, T., Nakajima, H., Kondo, T., Ishimaru, T.
- Journal Title
  
  Clinical Oncology, 17(4)
  
  Pages: 264-270
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590247
[Journal Article] Nuclear Localization of Glutathione S-Transferase π is an Evaluation Factor for Drug Resistance in Gynecological Cancers.2005
- Author(s)
  Soh, Y., Goto, S., et al.
- Journal Title
  
  Clinical Oncology 17(4)
  
  Pages: 264-270
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590247
[Journal Article] Nuc1ear glutathione S-transferase π prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA adducts.2004
- Author(s)
  Kamada, K., Goto, S., et al.
- Journal Title
  
  Free Radical. Biol. Med. 37(11)
  
  Pages: 1875-1884
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590247
[Journal Article] Nuclear glutathione S-transferase π prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA adducts.2004
- Author(s)
  Kamada, K., Goto, S., et al.
- Journal Title
  
  Free Radical.Biol.Med. 37(11)
  
  Pages: 1875-1884
- Data Source
  KAKENHI-PROJECT-16590247
[Journal Article] Nuclear glutathione S-transferase p prevents apoptosis by reducing the oxidative stress-induced formation of exocyclic DNA adducts.2004
- Author(s)
  Kamada, K., Goto, S., Okunaga, T., Ihara, Y., Tsuji, K., Kawai, Y., Uchida, K., Osawa, T., Matsuo, T., Nagata, I., Kondo, T.
- Journal Title
  
  Free Radical.Biol.Med., 37(11)
  
  Pages: 1875-1884
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590247
[Presentation] The effects of nicaraven on the survival of cancer cells and the growth of established tumors after radiation exposure2017
- Author(s)
  Chen Yan, Lan Luo, Yoshishige Urata, Shinji Goto, Tao-Sheng Li
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-17H04265
[Presentation] Radiation-induced damages on cardiac stem cells and myocardial regeneration may indirectly indicate future cardiovascular disease risks2016
- Author(s)
  Lan Luo1, Kodai Nishi2, Yoshishige Urata, Chen Yan, Shinji Goto, Takashi Kudo, Tao-Sheng Li
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  JMSアステールプラザ（広島県・広島市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-26293279
[Presentation] 放射線被ばくによる心血管疾患リスクに関する実験的科学評価2015
- Author(s)
  羅蘭、浦田芳重、後藤信治、小野悠介、李桃生
- Organizer
  第５６回原子爆弾後障害研究会
- Place of Presentation
  広島国際会議場
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-26293279
[Presentation] Radiation-induced damage of cardiac stem cells in quantity and quality2015
- Author(s)
  Lan Luo, Yoshishige Urata, Shinji Goto, Yusuke Ono, Tao-Sheng Li
- Organizer
  ICRR2015 Kyoto Japan - 15th International Congress of Radiation Research
- Place of Presentation
  京都府京都市国際会議場
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293279
[Presentation] The mechanism of drug resistance of CD133-expressed cancer cell2015
- Author(s)
  後藤信治、浦田芳重、小野悠介、李桃生
- Organizer
  日本生化学会
- Place of Presentation
  神戸国際会議場(神戸市、兵庫県）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25462061
[Presentation] Radiation-induced damage of cardiac stem cells in quantity and quality
- Author(s)
  Lan Luo, Yoshishige Urata, Shinji Goto, Yusuke Ono, Tao-Sheng Li
- Organizer
  ＩＣＲＲ２０１５
- Place of Presentation
  京都国際会館
- Year and Date
  2015-05-25 – 2015-05-29
- Data Source
  KAKENHI-PROJECT-26293279

1. URATA Yosisige (30185087)

# of Collaborated Projects: 8 results

# of Collaborated Products: 13 results
2. LI Taosheng (50379997)

# of Collaborated Projects: 7 results

# of Collaborated Products: 18 results
3. KONDO Takahito (00158908)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
4. IHARA Yoshito (70263241)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
5. KAWAKATSU Miho (20398150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. KOIKE Kichiko (80039619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 小池吉子 (10039521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 工藤崇 (20330300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 小野悠介 (60601119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 西弘大 (10719496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 黄文敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. LUO LAN

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

GOTO Shinji 後藤 信治

後藤 信治 ゴトウ シンジ

GOTO Shinzi 後藤 信治

GOTO Sinji 後藤 信治

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A new approach to cancer focusing on mitochondrial calciumPrincipal Investigator

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Development of novel cancer therapeutics targeting metabolic characteristics of cancer stem cellsPrincipal Investigator

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The explore of new cancer stem cell marker based on intracellular behavior of biological defense factorPrincipal Investigator

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Molecular mechanism of intracellular localization of glutathione S-transferase πPrincipal Investigator

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Basic Research of Novel Molecular Target on Cancer ChemotherapyPrincipal Investigator

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細胞におけるグルタチオン-シスプラチン結合体の形成と排出機構の解明Principal Investigator

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ガン細胞のシスプラチン耐性獲得機構の解明Principal Investigator

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GOTO Shinji 後藤信治

後藤信治ゴトウシンジ

GOTO Shinzi 後藤信治

GOTO Sinji 後藤信治