Akiyama Masahiro 秋山雅博

Researcher Number	60754570
Other IDs
Affiliation (Current)	2025: 昭和大学, 大学共同利用機関等の部局等, 准教授
Affiliation (based on the past Project Information) *help	2024: 昭和大学, 大学共同利用機関等の部局等, 准教授 2023: 昭和大学, 医学部, 准教授 2022 – 2023: 慶應義塾大学, 薬学部(芝共立), 特任講師 2020: 慶應義塾大学, 薬学部(芝共立), 特任講師 2016 – 2019: 筑波大学, 医学医療系, 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Environmental and hygienic pharmacy Except Principal Investigator Basic Section 58040:Forensics medicine-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Basic Section 47060:Clinical pharmacy-related / Broad Section K
Keywords	Principal Investigator 超硫黄分子 / 腸内細菌 / 活性イオウ分子 / 環境中化学物質 / 硫黄修飾 / 細胞外排出 / 還元ストレス / 低濃度曝露 / メチル水銀 Except Principal Investigator 質量分析 … More / 薬物代謝 / 薬物動態 / カフェイン代謝 / LC/MS/MS / 腸内細菌 / CYP1A2 / 急性カフェイン中毒 / カドミウム / 潰瘍性大腸炎 / 16S rRNA / プロトンポンプ阻害薬 / 胃酸分泌抑制薬 / 免疫チェックポイント阻害薬 / 腫瘍免疫応答 / 腸内細菌叢 / 生体内運命 / イオウ付加体 / レドックスシグナル / 毒性発現 / レドックスシグナル変動 / アンチポーター / 環境中親電子物 / 活性イオウ分子 / レドックスシグナル系 / タンパク質付加体 / エクスポソーム / 複合曝露 / 環境中親電子物質 Less

腸内細菌の環境ストレス制御における超硫黄分子の役割Principal Investigator
- Principal Investigator
  
  秋山雅博
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Showa University
硫黄修飾を介した腸内細菌の代謝機能制御Principal Investigator
- Principal Investigator
  
  秋山雅博
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Keio University
Elucidation of the effects of CYP1A2 and gut microbiota on acute caffeine intoxication
- Principal Investigator
  
  草野麻衣子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  Showa University
腸内細菌叢が免疫チェックポイント阻害薬の有効性に与える影響とメカニズムの解明
- Principal Investigator
  
  河添仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Keio University
Involvement of cadmium as an exacerbating factor in ulcerative colitis
- Principal Investigator
  
  Hwang Gi-Wook
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Tohoku Medical and Pharmaceutical University
腸内細菌による超硫黄分子産生機構の解明Principal Investigator
- Principal Investigator
  
  秋山雅博
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Keio University
Extracellular efflux of reactive sulfur species and its transportersPrincipal Investigator
- Principal Investigator
  
  Akiyama Masahiro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  University of Tsukuba
Environmental electrophiles exposome and reactive sulfur species as its regulator molecule
- Principal Investigator
  
  Kumagai Yoshito
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section K
- Research Institution
  University of Tsukuba
Role of reactive sulfur species as a key molecule to diminish toxicity of methylmercury in micePrincipal Investigator
- Principal Investigator
  
  Akiyama Masahiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  University of Tsukuba

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Supersulfides to Regulate Electrophilic Stress2024
- Author(s)
  Akiyama Masahiro、Uchiyama Jun、Kumagai Yoshito、Kim Yun-Gi
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 144 Issue: 1 Pages: 47-50
- DOI
  10.1248/yakushi.23-00162-2
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2024-01-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-23K18223, KAKENHI-PUBLICLY-22H05576, KAKENHI-PROJECT-23K27409
[Journal Article] Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress2022
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Aoki Hanako、Nishimura Akiyuki、Shinkai Yasuhiro、Warabi Eiji、Nishiyama Kazuhiro、Furumoto Yuka、Anzai Naohiko、Akaike Takaaki、Nishida Motohiro、Kumagai Yoshito
- Journal Title
  
  Redox Biology
  
  Volume: 57 Pages: 102514-102514
- DOI
  10.1016/j.redox.2022.102514
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06572, KAKENHI-PROJECT-22K19395, KAKENHI-PROJECT-22K19397, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05269, KAKENHI-PUBLICLY-22H05555, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-21H03065, KAKENHI-PUBLICLY-22H04799, KAKENHI-PLANNED-21H05263, KAKENHI-PROJECT-18H05277
[Journal Article] Concentrations of nucleophilic sulfur species in small Indian mongoose (Herpestes auropunctatus) in Okinawa, Japan2022
- Author(s)
  Horai Sawako、Abiko Yumi、Unoki Takamitsu、Shinkai Yasuhiro、Akiyama Masahiro、Nakata Katsushi、Kunisue Tatsuya、Kumagai Yoshito
- Journal Title
  
  Chemosphere
  
  Volume: 295 Pages: 133833-133833
- DOI
  10.1016/j.chemosphere.2022.133833
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] Potentiation of methylmercury toxicity by combined metal exposure: in vitro and in vivo models of a restricted metal exposome2022
- Author(s)
  Akiyama M., Shinkai Y., Yamakawa H., Kim Y.G., Kumagai Y.
- Journal Title
  
  Chemosphere
  
  Volume: - Pages: 134374-134374
- DOI
  10.1016/j.chemosphere.2022.134374
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21530, KAKENHI-PROJECT-20H03490, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-18H05293
[Journal Article] Capture of Electrophilic Quinones in the Extracellular Space: Evidence for a Phase Zero Reaction2022
- Author(s)
  Shinkai Yasuhiro、Onose Yusuke、Akiyama Masahiro、Hirose Reiko、Kumagai Yoshito
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 36 Issue: 1 Pages: 23-31
- DOI
  10.1021/acs.chemrestox.2c00223
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H05555, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340, KAKENHI-PUBLICLY-22H04799
[Journal Article] Gut Microbiota Reinforces Host Antioxidant Capacity via the Generation of Reactive Sulfur Species2022
- Author(s)
  Uchiyama J. , Akiyama M., Hase K., Kumagai Y., Kim Y.G.
- Journal Title
  
  Cell Reports
  
  Volume: 38(10) Issue: 10 Pages: 110479-110479
- DOI
  10.1016/j.celrep.2022.110479
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21530, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H03490, KAKENHI-PROJECT-20H00509
[Journal Article] Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain2022
- Author(s)
  Unoki Takamitsu、Akiyama Masahiro、Shinkai Yasuhiro、Kumagai Yoshito、Fujimura Masatake
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 47 Issue: 1 Pages: 31-37
- DOI
  10.2131/jts.47.31
- NAID
  130008139752
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340, KAKENHI-PROJECT-21K06572, KAKENHI-PROJECT-19K16368
[Journal Article] Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts2021
- Author(s)
  Abiko Yumi、Katayama Yusuke、Akiyama Masahiro、Kumagai Yoshito
- Journal Title
  
  Food and Chemical Toxicology
  
  Volume: 150 Pages: 112061-112061
- DOI
  10.1016/j.fct.2021.112061
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20K12180
[Journal Article] Adverse effects of methylmercury on gut bacteria and accelerated accumulation of mercury in organs due to disruption of gut microbiota2021
- Author(s)
  Seki N, Akiyama M, Yamakawa H, Hase K, Kumagai Y, Kim YG
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 2 Pages: 91-97
- DOI
  10.2131/jts.46.91
- NAID
  130007980544
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21530, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H03490
[Journal Article] Cysteine Trisulfide Protects E.?coli from Electrophile-Induced Death through the Generation of Cysteine Hydropersulfide2020
- Author(s)
  Henderson Catherine F.、Bica Iris、Long Faith T.、Irwin Drew D.、Stull Christine H.、Baker Blaine W.、Suarez Vega Valeria、Taugher Zachary M.、Fletes Eliza D.、Bartleson Juliet M.、Humphrey Megan L.、?lvarez Luc?a、Akiyama Masahiro、Kumagai Yoshito、Fukuto Jon M.、Lin Joseph
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 33 Issue: 2 Pages: 678-686
- DOI
  10.1021/acs.chemrestox.9b00494
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress2020
- Author(s)
  Unoki Takamitsu、Akiyama Masahiro、Kumagai Yoshito
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 2 Pages: 545-545
- DOI
  10.3390/ijms21020545
- NAID
  120007132700
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293
[Journal Article] Repression of mercury accumulation and adverse effects of methylmercury exposure is mediated by cystathionine γ-lyase to produce reactive sulfur species in mouse brain2020
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Yoshida Eiko、Ding Yunjie、Yamakawa Hiroto、Shinkai Yasuhiro、Ishii Isao、Kumagai Yoshito
- Journal Title
  
  Toxicology Letters
  
  Volume: 330 Pages: 128-133
- DOI
  10.1016/j.toxlet.2020.05.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide2020
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Kumagai Yoshito
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 7 Issue: 3 Pages: 161-166
- DOI
  10.2131/fts.7.161
- NAID
  130007840859
- ISSN
  2189-115X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] カドミウムによる親電子シグナル伝達経路の活性化と活性イオウ分子を介した制御2020
- Author(s)
  新開泰弘、秋山雅博、熊谷嘉人
- Journal Title
  
  硫酸と工業
  
  Volume: 73
- NAID
  40022236653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05293
[Journal Article] Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules2019
- Author(s)
  Kumagai Yoshito、Akiyama Masahiro、Unoki Takamitsu
- Journal Title
  
  Toxicological Research
  
  Volume: 35 Issue: 4 Pages: 303-310
- DOI
  10.5487/tr.2019.35.4.303
- NAID
  120007127813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293
[Journal Article] Emerging role of electrophiles as a key regulator for endoplasmic reticulum (ER) stress.2019
- Author(s)
  Takasugi, N., Hiraoka, H., Nakahara, K., Akiyama, S., Fujikawa, K., Nomura, R., Furuichi, M., and Uehara, T.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 20(7) Issue: 7 Pages: 1783-1783
- DOI
  10.3390/ijms20071783
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19490, KAKENHI-PROJECT-19K22498, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-17K08272, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-17H06170
[Journal Article] The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications.2019
- Author(s)
  Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, Kumagai Y.
- Journal Title
  
  Chem Res Toxicol
  
  Volume: 32 Issue: 3 Pages: 447-455
- DOI
  10.1021/acs.chemrestox.8b00340
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07099, KAKENHI-PUBLICLY-17H05519, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-18H05277, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18H05293
[Journal Article] Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Shinkai Yasuhiro、Ishii Isao、Ida Tomoaki、Akaike Takaaki、Yamamoto Masayuki、Kumagai Yoshito
- Journal Title
  
  Environmental Health Perspectives
  
  Volume: 127 Issue: 6 Pages: 067002-067002
- DOI
  10.1289/ehp4949
- NAID
  120007133174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16368, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-17K08619, KAKENHI-PROJECT-18K07099, KAKENHI-PROJECT-18H05277
[Journal Article] Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation2018
- Author(s)
  Unoki Takamitsu、Akiyama Masahiro、Kumagai Yoshito、Goncalves Filipe Marques、Farina Marcelo、da Rocha Joao Batista Teixeira、Aschner Michael
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 9 Pages: 373-373
- DOI
  10.3389/fgene.2018.00373
- NAID
  120007128084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中化学物質曝露による腸内細菌への影響2024
- Author(s)
  秋山雅博
- Organizer
  日本薬学会年会
- Data Source
  KAKENHI-PUBLICLY-22H05576
[Presentation] 環境中化学物質曝露による腸内細菌への影響2024
- Author(s)
  秋山雅博
- Organizer
  日本薬学会年会
- Data Source
  KAKENHI-PROJECT-23K06102
[Presentation] 環境中金属曝露による腸内細菌への影響2023
- Author(s)
  秋山雅博
- Organizer
  メタルバイオサイエンス研究会
- Data Source
  KAKENHI-PROJECT-23K06102
[Presentation] 腸内細菌の硫黄代謝と炎症抑制2023
- Author(s)
  秋山　雅博
- Organizer
  がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-23K06102
[Presentation] 超硫黄分子による親電子ストレス制御2023
- Author(s)
  秋山雅博
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H05576
[Presentation] 環境中金属曝露による腸内細菌への影響2023
- Author(s)
  秋山雅博
- Organizer
  メタルバイオサイエンス研究会
- Data Source
  KAKENHI-PUBLICLY-22H05576
[Presentation] 腸内細菌の硫黄代謝と炎症抑制2023
- Author(s)
  秋山雅博
- Organizer
  がんと代謝研究会
- Data Source
  KAKENHI-PUBLICLY-22H05576
[Presentation] Gut bacteria-derived supersulfide specie2023
- Author(s)
  Akiyama Masahiro
- Organizer
  日本生化学会大会
- Data Source
  KAKENHI-PUBLICLY-22H05576
[Presentation] Gut bacteria-derived supersulfide species2023
- Author(s)
  Akiyama Masahiro
- Organizer
  日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06102
[Presentation] シスチン要求性アンチポーターを介した過剰な活性イオウ分子の細胞外排出.2022
- Author(s)
  青木はな子、秋山雅博、鵜木隆光、蕨英治、西村明幸、西田基宏、熊谷嘉人
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 細胞外における大気中キノン化合物の不活性化に対するシステインの役割2022
- Author(s)
  広瀬玲子、新開泰弘、小野瀬祐輔、秋山雅博、熊谷嘉人
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 腸内細菌が産生する超硫黄分子の役割について2022
- Author(s)
  秋山雅博
- Organizer
  レドックス R&D 戦略委員会第 2 回若手シンポジウム
- Data Source
  KAKENHI-PUBLICLY-22H05576
[Presentation] メチル水銀曝露における細胞内サルフェン硫黄の遷移2022
- Author(s)
  鵜木隆光、秋山雅博、熊谷嘉人、藤村成剛
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 限定メタルエキスポソームのモデル化：銅の複合曝露によるメチル水銀毒性の増強2022
- Author(s)
  新開泰弘、秋山雅博、山川寛人、熊谷嘉人
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] シスチン要求性アンチポーターは硫黄ストレスを制御する2022
- Author(s)
  青木はな子、秋山雅博、鵜木隆光、蕨栄治、西村明幸、西田基宏、熊谷嘉人
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] The role of reactive sulfur species produced by gut bacteria2022
- Author(s)
  Masahiro Akiyama
- Organizer
  4th International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H05576
[Presentation] 腸内細菌による超硫黄分子産生と酸化ストレス防御への寄与2022
- Author(s)
  秋山雅博、内山純、熊谷嘉人、金倫基
- Organizer
  第49回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀曝露による細胞内サルフェン硫黄の遷移2022
- Author(s)
  鵜木隆光、秋山雅博、熊谷嘉人、藤村成剛
- Organizer
  フォーラム2022：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] メチル水銀曝露による脳中水銀蓄積と中毒症状は活性イオウ分子産生酵素CSEにより抑制される2021
- Author(s)
  鵜木隆光、秋山雅博、新開泰弘、石井功、熊谷嘉人
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Hexane Extract of Garlic Suppresses Methylmercury Mediated Toxicity2021
- Author(s)
  Abiko Y、Katayama Y、Akiyama M、Kumagai Y
- Organizer
  11th Congress of Toxicology in Developing Countries (CTDC11)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 銅の複合曝露で生じるレドックスホメオスタシスの破綻とメチル水銀によるタンパク質の化学修飾の増強2021
- Author(s)
  山川寛人、秋山雅博、熊谷嘉人
- Organizer
  令和2年度メチル水銀研究ミーティング
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 大気中キノン化合物の細胞外での捕獲：フェーズゼロ反応の提案2021
- Author(s)
  広瀬玲子、新開泰弘、小野瀬祐輔、秋山雅博、熊谷嘉人
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 腸内細菌由来活性イオウ分子が宿主の抗酸化能に及ぼす影響2021
- Author(s)
  内山純、秋山雅博、熊谷嘉人、金倫基
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 求核分子による大気中キノン化合物の細胞外での捕獲2021
- Author(s)
  広瀬玲子、新開泰弘、小野瀬祐輔、秋山雅博、熊谷嘉人
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄を介したメタロチオネイン-3のレドックス制御2021
- Author(s)
  新開泰弘、Yunjie Ding、秋山雅博、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2021
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子排出機構によるレドックス恒常性維持とフェーズゼロ反2020
- Author(s)
  秋山雅博、鵜木隆光、蕨栄治、西田基宏、本橋ほずみ、赤池孝章、熊谷嘉人
- Organizer
  第73回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 重金属/必須微量元素の複合曝露影響（メタルエクスポソーム）のモデル化．2020
- Author(s)
  山川寛人、秋山雅博、熊谷嘉人
- Organizer
  第19回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 環境中親電子物質に対する細胞外生体防御機構の実証．2020
- Author(s)
  小野瀬祐輔、秋山雅博、赤池孝章、熊谷嘉人
- Organizer
  第19回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 親電子性金属を中心としてメタルエクスポソームのモデル化2020
- Author(s)
  秋山雅博、山川寛人、熊谷嘉人
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子の細胞外排出機構．2020
- Author(s)
  秋山雅博、鵜木隆光、蕨栄治、本橋ほづみ、赤池孝章、熊谷嘉人
- Organizer
  第19回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 銅の複合曝露で生じるレドックスホメオスタシスの破綻とメチル水銀毒性の増強2020
- Author(s)
  秋山雅博、山川寛人、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2020
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 親電子ストレスに対する細胞外での意外な防御応答機構2020
- Author(s)
  小野瀬祐輔、秋山雅博、熊谷嘉人
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子の細胞外排出機構2020
- Author(s)
  秋山雅博
- Organizer
  第19回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-18K14895
[Presentation] 細胞内外のレドックスホメオスタシスを制御するアンチポーター2020
- Author(s)
  秋山雅博、鵜木隆光、青木はな子、熊谷嘉人
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子排出機構による還元ストレス制御とフェーズゼロ反応2020
- Author(s)
  秋山雅博
- Organizer
  20周年記念若手シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14895
[Presentation] ラマン分光法を用いたメタロチオネイン -3 の分子構造解析2020
- Author(s)
  新開泰弘、Yunjie Ding、秋山雅博、Sumeet Mahajan、熊谷嘉人
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄結合タンパク質の同定とその機能解析．2020
- Author(s)
  新開泰弘、Yunjie Ding、秋山雅博、井田智章、赤池孝章、熊谷嘉人
- Organizer
  第19回分子予防環境医学研究会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子を介した親電子ストレス防御2020
- Author(s)
  鵜木隆光、秋山雅博、新開泰弘、熊谷嘉人、藤村成剛
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子の脳内分布とメチル水銀感受性の連関2020
- Author(s)
  鵜木隆光、秋山雅博、熊谷嘉人、藤村成剛
- Organizer
  メタルバイオサイエンス研究会2020
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 金属の複合曝露で生じるレドックスホメオスタシスの破綻とそれに起因するタンパク質の化学修飾の増強2020
- Author(s)
  山川寛人、秋山雅博、熊谷嘉人
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄(sulfane sulfur)結合タンパク質としてのメタロチオネイン -3 の分子構造解析2020
- Author(s)
  新開泰弘、Yunjie Ding、秋山雅博、Sumeet Mahajan 、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2020
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE act as critical molecules in parallel pathways for regulation of electrophilic stress in mice2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Shinkai Yasuhiro、Ishii Isao、Jon M Fukuto、Akaike Takaaki、Yamamoto Masayuki、Kumagai Yoshito
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] カドミウム誘導性の生体応答および肝毒性は活性イオウ分子によって抑制される．2019
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子排出輸送機構によるレドックス制御.2019
- Author(s)
  秋山雅博、鵜木隆光、蕨栄治、新開泰弘、安孫子ユミ、石井功、山本雅之、赤池孝章、熊谷嘉人
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] CSEとNrf2は異なる経路を介して親電子ストレスを抑制する鍵分子である．2019
- Author(s)
  秋山雅博、鵜木隆光、新開泰弘、石井功、山本雅之、熊谷嘉人
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Metallothionein-3 as a sulfur binding protein: Identification, characterization and 3D structure modeling.2019
- Author(s)
  Shinakai Yasuhiro、Yunjie Ding、Akiyama Masahiro、Jon M Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  The Environmental Response V / 17th JBS Biofrontier Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE act as critical molecules in parallel pathways for regulation of electrophilic stress in mice.2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Shinkai Yasuhiro、Ishii Isao、Ida Tomoaki、Akaike Takaaki、Yamamto Masayuki、Kumagai Yoshito
- Organizer
  The Environmental Response V / 17th JBS Biofrontier Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 and CSE act as critical molecules in parallel pathways for repression of environmental electrophile-mediated toxicity in mice.2019
- Author(s)
  Shinakai Yasuhiro、Yunjie Ding、Akiyama Masahiro、Jon M Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子排出輸送機構によるレドックス制御.2019
- Author(s)
  秋山雅博
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K14895
[Presentation] メタルエキスポソームのモデル化．2019
- Author(s)
  秋山雅博、山川寛人、小野瀬祐輔、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Regulation of electrophilic stress by reactive persulfide released in out of cell:Phase-zero reaction.2019
- Author(s)
  Akiyama Masahiro、Unoki Takamizu、Warabi Eiji、Shinkai Yasuhiro、Ishii Isao、Joseph Lin、Motohashi Hozumi、Yamamoto Masayuki、Jon M. Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Regulation of electrophilic stress by reactive persulfide released in out of cell:Phase-zero reaction.2019
- Author(s)
  Masahiro Akiyama
- Organizer
  The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14895
[Presentation] Phase-zero reaction as a primary defense systeme against electrophilic stress in out of cell: Involvement of reactive persulfides.2019
- Author(s)
  Masahiro Akiyama
- Organizer
  1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14895
[Presentation] メチル水銀の細胞傷害特異性に対する含イオウ求核低分子の影響．2019
- Author(s)
  鵜木隆光、秋山雅博、熊谷嘉人、藤村成剛
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Identification, characterization and a three-dimensional structure modeling of metallothionein-3 as a sulfane sulfur- and zinc-binding protein.2019
- Author(s)
  Shinkai Yasuhiro、Yunjie Ding、Akiyama Masahiro、Unoki Takamitsu、Ida Tomoaki、Akaike Takaaki、Jon M. Fukuto、Kumagai Yoshito
- Organizer
  The Society for Redox Biology and Medicine's 26th Annual Conference (SfRBM 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Phase-zero reaction as a primary defense systeme against electrophilic stress in out of cell: Involvement of reactive persulfides.2019
- Author(s)
  Akiyama Masahiro、Unoki Takamitsu、Warabi Eiji、Shinkai Yasuhiro、Abiko Yumi、Ishii Isao、Joseph Lin、Motohashi Hozumi、Yamamoto Masayuki、Jon M. Fukuto、Akaike Takaaki、Kumagai Yoshito
- Organizer
  1st International Conference on Persulfide and Sulfur Metabolism in Biology and Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 亜鉛結合タンパク質のモデルとしてのメタロチオネイン-3 におけるサルフェン硫黄の役割．2019
- Author(s)
  Yunjie Ding、新開泰弘、秋山雅博、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] サルフェン硫黄結合タンパク質としてのメタロチオネイン-3 の機能と3 次元構造モデリング．2019
- Author(s)
  新開泰弘、Yunjie Ding、秋山雅博、熊谷嘉人
- Organizer
  フォーラム2019：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] A 3D structure modeling of metallothionein-3 and its related function as a sulfane sulfur binding protein．2019
- Author(s)
  Yunjie Ding、Shinkai Yasuhiro、Akiyama Masahiro、Kumagai Yoshito
- Organizer
  フォーラム2019：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2およびCSE は環境中親電子物質によるマウス肝細胞毒性の抑制に必須である2018
- Author(s)
  鵜木隆光、秋山雅博、新開泰弘、石井功、山本雅之、赤池孝章、熊谷嘉人
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子によるカドミウムのイオウ付加体の生成を介した毒性防御2018
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、熊谷嘉人
- Organizer
  生理学研究所研究会「生命のエネルギー獲得戦略における多様性と共通原理の理解にむけて」
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 小胞体レクチンシャペロン calreticulin の酸化による機能制御2018
- Author(s)
  秋山栞里、池尻七望、柴田万里、藤河香奈、高杉展正、柴田貴広、内田浩二、上原孝
- Organizer
  第18回日本NO学会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] CSEとNrf2は異なる経路を介して親電子性重金属毒性を抑制する鍵分子である2018
- Author(s)
  秋山雅博、鵜木隆光、新開泰弘、石井功、山本雅之、熊谷嘉人
- Organizer
  メタルバイオサイエンス研究会2018
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Nrf2 とCSE はメチル水銀中毒症状を抑制する鍵分子である2018
- Author(s)
  秋山雅博、鵜木隆光、新開泰弘、石井功、山本雅之、赤池孝章、熊谷嘉人
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子による還元ストレスのリスクとその制御機構2018
- Author(s)
  秋山雅博
- Organizer
  酸化ストレス学会
- Data Source
  KAKENHI-PROJECT-18K14895
[Presentation] ポリスルフィドによるカドミウムの不活性化を介した肝毒性の防御機構2018
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子によるカドミウムの不活性化を介した肝毒性の防御機構2018
- Author(s)
  新開泰弘、秋山雅博、鵜木隆光、石井功、熊谷嘉人
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] 活性イオウ分子：親電子ストレスに対する防御的役割とその細胞内過剰蓄積による還元ストレス2018
- Author(s)
  秋山雅博、鵜木隆光、蕨栄治、新開泰弘、石井功、赤池孝章、熊谷嘉人
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Cystathionine Gamma-Lyase Is a Key Protein Repressing Methylmercury Poisoning Symptoms in Mice2018
- Author(s)
  秋山雅博
- Organizer
  Society of Toxicology’s 57th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18919
[Presentation] 食用植物に含まれる活性イオウ分子種がメチル水銀毒性を低毒性化する2018
- Author(s)
  片山優助、安孫子ユミ、秋山雅博、熊谷嘉人
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] Persulfides and Polysulfides as Phytochemicals to Detoxify MeHg2018
- Author(s)
  Abiko Yumi、Katayama Yusuke、Akiyama Masahiro、Kumagai Yoshito
- Organizer
  The 8th International Congress of Asian Society of Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05293
[Presentation] CSE欠損による親電子ストレスに対する感受性増強とCSE高発現による還元ストレスに対する生体応答2017
- Author(s)
  秋山雅博
- Organizer
  フォーラム2017 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-16K18919
[Presentation] メチル水銀毒性制御における求核低分子の役割2017
- Author(s)
  秋山雅博
- Organizer
  メチル水銀研究ミーティング
- Data Source
  KAKENHI-PROJECT-16K18919
[Presentation] Role of reactive sulfur species as a key molecule to diminish toxicity of the environmental electrophile in mice2016
- Author(s)
  秋山雅博
- Organizer
  国際NO学会
- Place of Presentation
  宮城県仙台市仙台国際センター
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18919
[Presentation] Cystathionine gamma-lyaseはメチル水銀中毒症状を抑制する鍵分子である2016
- Author(s)
  秋山雅博
- Organizer
  フォーラム2016 衛生薬学・環境トキシコロジー
- Place of Presentation
  東京都昭和大学旗の台キャンパス
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-16K18919
[Presentation] システイン代謝酵素によるメチル水銀毒性制御に関する研究2016
- Author(s)
  秋山雅博
- Organizer
  メチル水銀研究ミーティング
- Place of Presentation
  東京都 LMJ東京研修センター
- Year and Date
  2016-12-26
- Data Source
  KAKENHI-PROJECT-16K18919
[Presentation] システイン代謝酵素によるレドックス制御とメチル水銀毒性との関係」2016
- Author(s)
  秋山雅博
- Organizer
  生体と金属・化学物質に関する研究会
- Place of Presentation
  宮城県仙台市一の坊
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-16K18919
[Presentation] メチル水銀曝露による健康リスクを制御する活性イオウ分子の役割2016
- Author(s)
  秋山雅博
- Organizer
  日本毒性学会学術年会
- Place of Presentation
  愛知県名古屋市ウインクあいち
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-16K18919

1. Kumagai Yoshito (00250100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 58 results
2. Hwang Gi-Wook (00344680)

# of Collaborated Projects: 1 results

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3. 上原孝 (00261321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 西田基宏 (90342641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 伊藤昭博 (40391859)

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# of Collaborated Products: 14 results
6. 新開泰弘 (10454240)

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# of Collaborated Products: 34 results
7. 河添仁 (60527563)

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# of Collaborated Products: 0 results
8. 金倫基 (00620220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 山縣涼太 (20963424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 草野麻衣子 (60733574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 鵜木隆光

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
12. 井田智章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akiyama Masahiro 秋山 雅博

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腸内細菌の環境ストレス制御における超硫黄分子の役割Principal Investigator

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硫黄修飾を介した腸内細菌の代謝機能制御Principal Investigator

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Elucidation of the effects of CYP1A2 and gut microbiota on acute caffeine intoxication

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腸内細菌叢が免疫チェックポイント阻害薬の有効性に与える影響とメカニズムの解明

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Involvement of cadmium as an exacerbating factor in ulcerative colitis

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腸内細菌による超硫黄分子産生機構の解明Principal Investigator

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Extracellular efflux of reactive sulfur species and its transportersPrincipal Investigator

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Environmental electrophiles exposome and reactive sulfur species as its regulator molecule

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Role of reactive sulfur species as a key molecule to diminish toxicity of methylmercury in micePrincipal Investigator

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[Journal Article] Supersulfides to Regulate Electrophilic Stress2024

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[Journal Article] Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress2022

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[Journal Article] Concentrations of nucleophilic sulfur species in small Indian mongoose (Herpestes auropunctatus) in Okinawa, Japan2022

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[Journal Article] Potentiation of methylmercury toxicity by combined metal exposure: in vitro and in vivo models of a restricted metal exposome2022

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Akiyama Masahiro 秋山雅博