Yoshino Yuki 吉野優樹

Researcher Number	60755700
Other IDs
Affiliation (Current)	2025: 東北大学, 加齢医学研究所, 助教
Affiliation (based on the past Project Information) *help	2016 – 2024: 東北大学, 加齢医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology Except Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology
Keywords	Principal Investigator 中心体 / BRCA1 / 遺伝性乳がん / 乳がん / RACK1 / PLK1 / 組織特異性 / 発がん予防 / 局在制御 / 翻訳後修飾 … More / 中心小体 / 発がん / Aurora A / 中心体制御機構 / 染色体不安定性 / 発がん機構 / 癌 / 相同組換え修復 … More Except Principal Investigator がん / 中心体 / がん関連分子 / がん治療 / ゲノム不安定性 / DNA損傷 / DNA損傷応答 / 癌 / 細胞分裂 / ゲノム安定性維持 / BRCA1 Less

中心小体複製の組織特異性に基づくBRCA1関連乳がんの発がん機構の解明Principal Investigator
- Principal Investigator
  
  吉野優樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Development of cancer therapy targeting genome instability by centrosome dysregulation and DNA damage
- Principal Investigator
  
  千葉奈津子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Tissue-specific carcinogenesis due to dysregulation of centrosome duplication by BRCA1 complexPrincipal Investigator
- Principal Investigator
  
  Yoshino Yuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Development of Targeting therapy for centrosome dysregulation in cancer
- Principal Investigator
  
  Chiba Natsuko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
The mechanism of tissue specific carcinogenesis by the deficiency of the centrosomal BRCA1 complexPrincipal Investigator
- Principal Investigator
  
  Yoshino Yuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Elucidation of regulatory mechanism to maintain genome stability by novel BRCA1-interacting molecules and development of cancer therapy
- Principal Investigator
  
  CHIBA Natsuko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tohoku University
Centrosomal BRCA1 complex: As a new therapeutic targetPrincipal Investigator
- Principal Investigator
  
  Yoshino Yuki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

[Book] New functions of BRCA1/2 in regulating carcinogenesis and drug sensitivity. Practical Guide to Hereditary Breast and Ovarian cancer - Annual meeting of the Japanese Organization of Hereditary Breast and Ovarian Cancer2023
- Author(s)
  Fang Zhenzhou、Yoshino Yuki、Chiba Natsuko
- Total Pages
  17
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-23K24157
[Book] Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice, Variants of uncertain significances in hereditary breast and ovarian cancer2021
- Author(s)
  Yuki Yoshino and Natsuko Chiba
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-19H03493
[Journal Article] Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification2024
- Author(s)
  Yoshino Yuki、Ogoh Honami、Iichi Yudai、Sasaki Tomohiro、Yoshida Takahiro、Ichimura Shiori、Nakayama Masahiro、Xi Wu、Fujita Hiroki、Kikuchi Megumi、Fang Zhenzhou、Li Xingming、Abe Takaya、Futakuchi Mitsuru、Nakamura Yasuhiro、Watanabe Toshio、Chiba Natsuko
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1870 Issue: 5 Pages: 167138-167138
- DOI
  10.1016/j.bbadis.2024.167138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24157
[Journal Article] The centrosome: a critical hub for cell cycle regulation2024
- Author(s)
  Yoshino Yuki、Fang Zhenzhou、Chiba Natsuko
- Journal Title
  
  Trends in Cell Biology
  
  Volume: - Issue: 6 Pages: 437-439
- DOI
  10.1016/j.tcb.2024.04.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24157
[Journal Article] Protocol to detect OLA1 polyubiquitination by Aurora A in vivo and in vitro2024
- Author(s)
  Fang Zhenzhou、Li Xingming、Yoshino Yuki、Chiba Natsuko
- Journal Title
  
  STAR Protocols
  
  Volume: 5 Issue: 2 Pages: 103008-103008
- DOI
  10.1016/j.xpro.2024.103008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14584, KAKENHI-PROJECT-23K24157
[Journal Article] Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation2023
- Author(s)
  Fang Zhenzhou、Li Xingming、Yoshino Yuki、Suzuki Moe、Qi Huicheng、Murooka Hinari、Katakai Riko、Shirota Matsuyuki、Mai Pham Thi Anh、Matsuzawa Ayako、Otsuka Kei、Ishioka Chikashi、Mori Takahiro、Chiba Natsuko
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 8 Pages: 112850-112850
- DOI
  10.1016/j.celrep.2023.112850
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14584, KAKENHI-PROJECT-22K12241, KAKENHI-PROJECT-23K24157
[Journal Article] <scp>BRCA1</scp> transports the <scp>DNA</scp> damage signal for <scp>CDDP</scp> ‐induced centrosome amplification through the centrosomal Aurora A2022
- Author(s)
  Qi Huicheng、Kikuchi Megumi、Yoshino Yuki、Fang Zhenzhou、Ohashi Kazune、Gotoh Takato、Ideta Ryo、Ui Ayako、Endo Shino、Otsuka Kei、Shindo Norihisa、Gonda Kohsuke、Ishioka Chikashi、Miki Yoshio、Iwabuchi Tokuro、Chiba Natsuko
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 12 Pages: 4230-4243
- DOI
  10.1111/cas.15573
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07143, KAKENHI-PROJECT-23K24157
[Journal Article] Roles of RACK1 in centrosome regulation and carcinogenesis2022
- Author(s)
  Yoshino Y and Chiba N
- Journal Title
  
  Cellular Signalling
  
  Volume: 90 Pages: 110207-110207
- DOI
  10.1016/j.cellsig.2021.110207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03493, KAKENHI-PROJECT-21K07143
[Journal Article] BRCA1/ATF1-mediated transactivation is involved in resistance to PARP inhibitors and cisplatin2021
- Author(s)
  Endo S, Yoshino Y, Shirota M, Watanabe G, and Chiba N
- Journal Title
  
  Cancer Research Communications
  
  Volume: 1(2) Issue: 2 Pages: 90-105
- DOI
  10.1158/2767-9764.crc-21-0064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03493
[Journal Article] Dysregulation of the centrosome induced by BRCA1 deficiency contributes to tissue‐specific carcinogenesis2021
- Author(s)
  Yoshino Yuki、Fang Zhenzhou、Qi Huicheng、Kobayashi Akihiro、Chiba Natsuko
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 5 Pages: 1679-1687
- DOI
  10.1111/cas.14859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15233, KAKENHI-PROJECT-19H03493, KAKENHI-PROJECT-21K07143
[Journal Article] The Function of BARD1 in Centrosome Regulation in Cooperation with BRCA1/OLA1/RACK12020
- Author(s)
  Otsuka Kei、Yoshino Yuki、Qi Huicheng、Chiba Natsuko
- Journal Title
  
  Genes
  
  Volume: 11 Issue: 8 Pages: 842-842
- DOI
  10.3390/genes11080842
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18020, KAKENHI-PROJECT-19H03493, KAKENHI-PROJECT-18K15233
[Journal Article] RACK1 regulates centriole duplication through the activation of polo-like kinase 1 by Aurora A.2020
- Author(s)
  Yoshino Y*, Kobayashi A*, Qi H, Endo S, Fang Z, Shindo K, Kanazawa R, Chiba N
- Journal Title
  
  Journal of Cell Science
  
  Volume: 133 Issue: 17 Pages: 238931-238931
- DOI
  10.1242/jcs.238931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03493, KAKENHI-PROJECT-18K15233
[Journal Article] RACK1 regulates centriole duplication by controlling localization of BRCA1 to the centrosome in mammary tissue-derived cells.2019
- Author(s)
  Yoshino Y, Qi H, Kanazawa R, Sugamata M, Suzuki K, Kobayshi A, Shindo K, Matsuzawa A, Shibata S, Endo S, Miyanishi Y, Shimaoka T, Ishioka C, Kanno S, Yasui A, and Chiba N.
- Journal Title
  
  Oncogene
  
  Volume: 印刷中 Issue: 16 Pages: 3077-3092
- DOI
  10.1038/s41388-018-0647-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-19H03493
[Journal Article] BRCA1-interacting protein OLA1 requires interaction with BARD1 to regulate centrosome number.2018
- Author(s)
  Yoshino Y, Qi H, Fujita H, Shirota M, Abe S, Komiyama Y, Shindo K, Nakayama M, Matsuzawa A, Kobayashi A, Ogoh H, Watanabe T, Ishioka C and Chiba N.
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 6(10) Issue: 10 Pages: 1499-1511
- DOI
  10.1158/1541-7786.mcr-18-0269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-16K07296
[Journal Article] OLA1 gene sequencing in patients with BRCA1/2 mutation-negative suspected hereditary breast and ovarian cancer.2016
- Author(s)
  Takahashi M*, Chiba N*, Shimodaira H, Yoshino Y, Mori T, Sumii M, Nomizu T, Ishioka C.
- Journal Title
  
  Breast Cancer
  
  Volume: 24(2) Issue: 2 Pages: 336-340
- DOI
  10.1007/s12282-016-0709-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-26460958
[Patent] 相同組み換え修復活性の定量法2017
- Inventor(s)
  吉野優樹、千葉奈津子、遠藤栞乃
- Industrial Property Rights Holder
  吉野優樹、千葉奈津子、遠藤栞乃
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-250777
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K18409
[Presentation] BARD1 suppresses the OLA1 polyubiquitination by Aurora A to regulate centrosome maturation.2023
- Author(s)
  Li X, Fang Z, Murooka H, Watanabe M, Yoshino Y, Mori T, and Chiba N
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] BRCA1-associated protein RACK1 regulates centrosome duplication in breast cancer cells.2023
- Author(s)
  Yoshino Y, Fang Z, and Chiba N
- Organizer
  第8回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] BRCA1結合分子RACK1による中心体複製制御機構の解析2023
- Author(s)
  吉野優樹、方震宙、千葉奈津子
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07143
[Presentation] Aurora A ubiquitinates the BRCA1-interacting protein OLA1 to regulate centrosome maturation2023
- Author(s)
  千葉奈津子, 方震宙, 李星明, 吉野優樹, 森隆弘.
- Organizer
  第46回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] BRCA1-interacting protein OLA1 promotes DNA damage-induced centrosome amplification through the activation of PLK1.2023
- Author(s)
  Fang Z, Kobayashi R, Hsiao T, Yoshino Y, Qi, H and Chiba N.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] NEK2 regulates centrosome number through promoting OLA1 ubiquitination by Aurora A.2022
- Author(s)
  Fang Z, Li X, Yoshino Y, Ishioka C, Mori T, and Chiba N.
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] NEK2はAurora AによるOLA1のユビキチン化を促進して中心体数を制御する2022
- Author(s)
  方震宙、李星明、吉野優樹、石岡千加史、森隆弘、千葉奈津子
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07143
[Presentation] BRCA1 is involved in the ubiquitination of OLA1 by Aurora A to promote centrosome maturation.2022
- Author(s)
  Li X, Fang Z, Yoshino Y, Ishioka C, Mori T, and Chiba N.
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] BRCA1はAurora AによるOLA1のユビキチン化に作用して中心体成熟を促進する2022
- Author(s)
  李星明、方震宙、吉野優樹、石岡千加史、森隆弘、千葉奈津子
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07143
[Presentation] Effects of functional changes in hereditary breast cancer gene products on carcinogenesis and drug resistance2022
- Author(s)
  吉野優樹, 遠藤栞乃, 千葉奈津子
- Organizer
  第81回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K24157
[Presentation] BRCA1とその関連分子の変化による中心体制御異常とゲノム不安定性2022
- Author(s)
  千葉奈津子、吉野優樹、方震宙
- Organizer
  第81回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07143
[Presentation] Aurora A-dependent ubiquitination of OLA1 regulates centrosome number through controlling the recruitment of PCM proteins2021
- Author(s)
  Zhenzhou Fang, Xingming Li, Moe Suzuki, Yuki Yoshino, Huicheng Qi, Takahiro Mori, and Natsuko Chiba
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] 中心体におけるBRCA1の局在部位とその制御機構の解析2021
- Author(s)
  吉野優樹、千葉奈津子
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07143
[Presentation] Regulatory mechanism of precise localization of BRCA1 in centrosome2021
- Author(s)
  Yuki Yoshino, Natsuko Chiba
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] Aurora AによるOLA1のユビキチン化はPCMを制御して中心体数をコントロールする2021
- Author(s)
  方震宙、李星明、鈴木萌、吉野優樹、斉匯成、森隆弘、千葉奈津子
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07143
[Presentation] BRCA1はATMによるリン酸化を介してDNA損傷シグナルを中心体に輸送する2021
- Author(s)
  千葉奈津子、菊池めぐみ、方震宙、後藤孝太、吉野優樹、石岡千加史、斉匯成
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07143
[Presentation] BRCA1 transports DNA-damaging signal to centrosome through its phosphorylation by ATM2021
- Author(s)
  Natsuko Chiba, Megumi Kikuchi, Zhenzhou Fang, Takato Goto, Yuki Yoshino, Chikashi Ishioka, and Huicheng Qi
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] アセチルサリチル酸はBRCA1障害に起因する中心体増幅を抑制する.2020
- Author(s)
  吉野優樹、遠藤栞乃、千葉奈津子
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] Dysfunction of centrosome regulation by BRCA1-containing complex increases tumor heterogeneity.2020
- Author(s)
  Natsuko Chiba, Huicheng Qi, Yuki Yoshino.
- Organizer
  AACR Virtual Special Conference: Tumor Heterogeneity: Form Single cell to Clinical Impact
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] BRCA1関連乳がんの新たな診断法の開発と発がん機構の解析.2020
- Author(s)
  吉野優樹、遠藤栞乃、渡部剛、千葉奈津子
- Organizer
  第8回HBOCコンソーシアム学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] BRCA1関連乳がんの新たな診断法の開発と発がん機構の解析.2020
- Author(s)
  吉野優樹, 遠藤栞乃, 渡部剛, 千葉奈津子.
- Organizer
  第8回HBOCコンソーシアム学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] リン酸化BRCA1はAurora Aの中心体局在を介してDNA損傷後の中心体増幅を制御する2020
- Author(s)
  斉匯成、吉野優樹、菊池めぐみ、方震宙、石岡千加史、千葉奈津子.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] BRCA1関連乳がんの新たな診断法の開発と発がん機構の解析2020
- Author(s)
  吉野優樹、遠藤栞乃、渡部剛、千葉奈津子
- Organizer
  第8回HBOCコンソーシアム学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] Investigation and preclinical development on BRCA1 molecular function.2020
- Author(s)
  Yuki Yoshino、Shino Endo、Huicheng Qi、Zhenzhou Fang、Natsuko Chiba
- Organizer
  The 15th International Symposium of the Institute Network for Biomedical Sciences
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] A novel BRCA1-interacting protein, RACK1, contributes centriole duplication in mammary cells via regulation of PLK1.2019
- Author(s)
  Yoshino Y, Kobayashi A, Qi H, Endo S, Fang Z, Chiba N.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] Aurora AによるOLA1のユビキチン化は中心体複製制御に重要である2019
- Author(s)
  方震宙, 齋匯成, 森隆弘, 吉野優樹, 鈴木萌, 石岡千加史, 千葉奈津子.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] Centrosome regulation by a novel BRCA1 complex: insight into tissue-specific carcinogenesis.2019
- Author(s)
  Yoshino Y, Qi H, Endo S, Fang Z, Otsuka K, Chiba N.
- Organizer
  The 14th International Symposium of the Institute Network for Biomedical Sciences
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] A novel assay to evaluate the activity of homologous recombination in cells2019
- Author(s)
  Shino Endo、Yuki Yoshino、Natsuko Chiba
- Organizer
  The 14th International Symposium of the Institute Network for Biomedical Sciences
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] Aurora AによるOLA1のユビキチン化は中心体複製制御に重要である2019
- Author(s)
  方震宙、齋匯成、森隆弘、吉野優樹、、鈴木萌、石岡千加史、千葉奈津子
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] 新規HR活性測定法ASHRAはPARP阻害薬感受性を予測可能である2019
- Author(s)
  遠藤栞乃、吉野優樹、千葉奈津子
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] A novel BRCA1-interacting protein, RACK1, contributes centriole duplication in mammary cells via regulation of PLK12019
- Author(s)
  Yuki Yoshino、Akihiro Kobayashi、Huicheng Qi、Shino Endo、Zhenzhou Fang、Natsuko Chiba
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] BRCA1はDNA損傷後のAurora Aの中心体局在を制御するv2019
- Author(s)
  菊池めぐみ、齋匯成、趙懿、方震宙、吉野優樹、千葉奈津子
- Organizer
  第３７回染色体ワークショップ・第１８回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] 新規BRCA1結合分子であるOLA1とRACK1は中心体複製を制御してゲノム安定性に寄与する2019
- Author(s)
  千葉奈津子、吉野優樹、齋匯成、遠藤栞乃、方震宙、石岡千加史、安井明
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] BARD1アイソフォームの発現は中心体の異常な伸長を引き起こす.2019
- Author(s)
  大塚慧, 内山千尋, 吉野優樹, 齋匯成, 千葉奈津子.
- Organizer
  第42回分子生物学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] BRCA1はDNA損傷後のAurora Aの中心体局在を制御する.2019
- Author(s)
  菊地めぐみ, 齋匯成, 趙懿, 方震宙, 吉野優樹, 千葉奈津子.
- Organizer
  第３７回染色体ワークショップ・第１８回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] 新規BRCA1結合分子であるOLA1とRACK1は中心体複製を制御してゲノム安定性に寄与する2019
- Author(s)
  千葉奈津子, 吉野優樹, 斉匯成, 遠藤栞乃, 方震宙, 石岡千加史, 安井明
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] BRCA1とその関連分子による中心体のDNA損傷応答機構の解明2019
- Author(s)
  斉匯成、菊地めぐみ、大橋和音、方震宙、吉野優樹、千葉奈津子
- Organizer
  第３７回染色体ワークショップ・第１８回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] Centrosome regulation by a novel BRCA1 complex: insight into tissue-specific carcinogenesis2019
- Author(s)
  Yuki Yoshino、Huicheng Qi、Shino Endo、Zhenzhou Fang、Kei Otsuka、Natsuko Chiba
- Organizer
  The 14th International Symposium of the Institute Network for Biomedical Sciences
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] BRCA1とその関連分子による中心体のDNA損傷応答機構の解明.2019
- Author(s)
  斉匯成, 菊地めぐみ, 大橋和音, 方震宙, 吉野優樹, 千葉奈津子.
- Organizer
  第３７回染色体ワークショップ・第１８回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] BARD1アイソフォームの発現は中心体の異常な伸長を引き起こす2019
- Author(s)
  大塚慧、内山千尋、吉野優樹、齋匯成、千葉奈津子
- Organizer
  第42回分子生物学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] 中心体制御における新規BRCA1結合因子OLA1とBARD1の相互作用の重要性.2018
- Author(s)
  吉野優樹、齋匯成、藤田拡樹、小林輝大、千葉奈津子.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] BRCA1結合分子BIP2の過剰発現はPLK1とAurora Aの活性化により中心体過剰複製を引き起こす.2018
- Author(s)
  小林輝大、吉野優樹、千葉奈津子
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15233
[Presentation] BRCA１結合分子BIP2の過剰発現はPLK1とAurora Aの活性化により中心体過剰複製を引き起こす2018
- Author(s)
  小林輝大, 吉野優樹, 千葉奈津子
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 新規BRCA1結合分子RACK1 の中心体複製制御能2018
- Author(s)
  吉野優樹, 齋匯成, 小林輝大, 遠藤栞乃, 方震宙, 千葉奈津子.
- Organizer
  第36回染色体ワークショップ第17回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] Function of BRCA1-interacting proteins OLA1 and BIP in centrosome and carcinogenesis2018
- Author(s)
  Yuki Yoshino, Huicheng Qi, Kei Otsuka, and Natsuko Chiba
- Organizer
  BASSER CENTER FOR BRCA 6th Annual Scientific Symposium BRCA1, BRCA2 and Beyond: An Update on hereditary Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 中心体制御における新規BRCA1結合因子OLA1とBARD1の相互作用の重要性2018
- Author(s)
  吉野優樹, 齋匯成, 藤田拡樹, 小林輝大, 千葉奈津子.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1結合分子OLA1の中心体のDNA損傷応答における機能2017
- Author(s)
  齋匯成, 方震宙, 新藤一葉, 吉野優樹, 千葉奈津子.
- Organizer
  第34回染色体ワークショップ
- Place of Presentation
  木更津
- Year and Date
  2017-01-11
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1の新規結合分子Ola1のノックアウトマウスの表現型の解析.2017
- Author(s)
  吉田貴大, 吉野優樹, 小河穂波, 佐々木伯大, 中村保宏, 渡邊利雄, 千葉奈津子.
- Organizer
  生命科学系学会合同年次大会　ConBio2017
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1 supresses centrosome amplification induced by BIP2 over-expression in mammary epithelial cells.2017
- Author(s)
  Shino Endo, Yuki Yoshino, Akihiro Kobayashi, Qi Huicheng, Natsuko Chiba.
- Organizer
  第75回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1-interacting protein OLA1 is involved in the centrosomal duplication and response to DNA damage.2017
- Author(s)
  Huicheng Qi, Kazune Ohashi, Fang Zhenzhou, Yuki Yoshino, Natsuko Chiba.
- Organizer
  The 33rd International Symposium of Radiation Biology Center, Kyoto University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] Function of the novel BRCA1-interacting protein OLA1 in centrosomal regulation and carcinogenesis.2017
- Author(s)
  Yuki Yoshino, Huicheng Qi, Natsuko Chiba.
- Organizer
  2nd Global Onsight Conference on Breast Cancer
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1は乳腺上皮細胞においてBIP2の過剰発現による中心体過剰複製を抑制する2017
- Author(s)
  遠藤栞乃、吉野優樹、小林輝大、齋匯成、千葉奈津子
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K18409
[Presentation] BRCA1結合分子OLA1による中心体のDNA損傷応答機構の解明2017
- Author(s)
  齋匯成, 吉野優樹, 方震宙,千葉奈津子.
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] DNA損傷後の中心体数の増加のメカニズムの解明.2017
- Author(s)
  斉匯成, 大橋和音, 方震宙, 吉野優樹, 千葉奈津子.
- Organizer
  第34回染色体ワークショップ第15回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 新規中心体制御因子RACK1によるBRCA1中心体局在制御と発がん2017
- Author(s)
  吉野優樹, 小林輝大, 菅股眞美, 早坂美月, 齋匯成, 千葉奈津子.
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 新規BRCA1結合分子BIP2とBRCA1のバランスが正常な中心体複製に重要である.2017
- Author(s)
  吉野優樹、小林輝大、宮西優太郎、齋匯成、遠藤栞乃、新藤一葉、千葉奈津子
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K18409
[Presentation] BRCA1-interacting protein OLA1 regulates centrosome amplification induced by DNA damage2017
- Author(s)
  Huicheng Qi, Yuki Yoshino, Natsuko Chiba.
- Organizer
  生命科学系学会合同年次大会　ConBio2017
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 中心体制御因子としての新規BRCA1結合因子BIP2の同定2016
- Author(s)
  吉野優樹, 齋匯成, 石岡千加史, 安井明, 千葉奈津子.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1依存性に中心体数を制御する新規中心体タンパク質BIP2の同定2016
- Author(s)
  吉野優樹, 齋匯成, 菅股眞美, 安井明, 千葉奈津子.
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 新規中心体タンパク質BIP2はBRCA1依存性に中心体数を制御する2016
- Author(s)
  吉野優樹、齋匯成、菅股眞美、安井明、千葉奈津子
- Organizer
  第89回日本生化学大会
- Place of Presentation
  宮城・仙台
- Year and Date
  2016-09-27
- Data Source
  KAKENHI-PROJECT-16K18409
[Presentation] 新規中心体タンパク質BIP2はBRCA1の中心体局在制御に関与する2016
- Author(s)
  新藤一葉、吉野優樹、齋匯成、菅股眞美、早坂美月、千葉奈津子
- Organizer
  第89回日本生化学大会
- Place of Presentation
  宮城・仙台
- Year and Date
  2016-09-27
- Data Source
  KAKENHI-PROJECT-16K18409
[Presentation] 新規中心体タンパク質BIP2はBRCA1の中心体局在と発がん機構に関与する2016
- Author(s)
  齋匯成, 吉野優樹, 石岡千加史, 千葉奈津子.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 新規中心体タンパク質BIP2はBRCA1の中心体局在と発がん機構に関与する2016
- Author(s)
  齋匯成、吉野優樹、石岡千加史、千葉奈津子
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川・横浜
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-16K18409
[Presentation] 中心体制御因子としての新規BRCA1結合因子BIP2の同定.2016
- Author(s)
  吉野優樹、齋匯成、石岡千加史、安井明、千葉奈津子
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川・横浜
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-16K18409
[Presentation] 新規中心体タンパク質BIP2はBRCA1の中心体局在制御に関与する2016
- Author(s)
  新藤一葉, 吉野優樹, 齋匯成, 菅股眞美, 早坂美月, 千葉奈津子.
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H04690

1. CHIBA Natsuko (50361192)

# of Collaborated Projects: 5 results

# of Collaborated Products: 55 results
2. 城田松之 (00549462)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. 渡部剛 (70451573)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 渡邊利雄 (60201208)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大塚慧 (20772437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 方震宙 (40963806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
7. KOBAYASHI Akihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. SUZUKI Kenta

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SUGAMATA Mami

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. ENDO Shino

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 渡辺利雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Yoshino Yuki 吉野 優樹

Research Projects

Research Products

Co-Researchers

中心小体複製の組織特異性に基づくBRCA1関連乳がんの発がん機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of cancer therapy targeting genome instability by centrosome dysregulation and DNA damage

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tissue-specific carcinogenesis due to dysregulation of centrosome duplication by BRCA1 complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Targeting therapy for centrosome dysregulation in cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of tissue specific carcinogenesis by the deficiency of the centrosomal BRCA1 complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of regulatory mechanism to maintain genome stability by novel BRCA1-interacting molecules and development of cancer therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Centrosomal BRCA1 complex: As a new therapeutic targetPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] New functions of BRCA1/2 in regulating carcinogenesis and drug sensitivity. Practical Guide to Hereditary Breast and Ovarian cancer - Annual meeting of the Japanese Organization of Hereditary Breast and Ovarian Cancer2023

Author(s)

Total Pages

Publisher

Data Source

[Book] Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice, Variants of uncertain significances in hereditary breast and ovarian cancer2021

Author(s)

Publisher

Data Source

[Journal Article] Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The centrosome: a critical hub for cell cycle regulation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protocol to detect OLA1 polyubiquitination by Aurora A in vivo and in vitro2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <scp>BRCA1</scp> transports the <scp>DNA</scp> damage signal for <scp>CDDP</scp> ‐induced centrosome amplification through the centrosomal Aurora A2022

Author(s)

Journal Title

DOI

Data Source

Yoshino Yuki 吉野優樹