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UESUGI Seiichi  上杉 晴一

ORCIDConnect your ORCID iD *help
Researcher Number 70028851
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2002: 横浜国立大学, 大学院・環境情報研究科, 教授
2001 – 2002: 横浜国立大学, 大学院・環境情報研究院, 教授
1991 – 2000: Associate Professor, Faculty of Pharmaceutical Sciences, Osaka University. (Pres, 工学部, 教授
1993: 東京工業大学, 生命理工学部, 教授
1986 – 1991: 大阪大学, 薬学部, 助教授 … More
1987 – 1988: 大阪大学, 薬学部・薬化学, 助教授
1986: 阪大, 薬学部, 助教授
1985: 大阪大学, 薬, 助教授 Less
Review Section/Research Field
Principal Investigator
Physical pharmacy / 環境影響評価(含放射線生物学) / Chemical pharmacy
Except Principal Investigator
Biological pharmacy / Hygiene / 分子遺伝学・分子生理学 / Physical pharmacy / 生物物性学
Keywords
Principal Investigator
NMR / 構造 / RNA / リボザイム / c-Myc / Max / タンパク質 / 肝炎デルタウィルス / 分子生物学 / 金属酵素 … More / CD / c-myc / 蛋白質 / 遺伝子工学 / DNA / アデニレ-トキナ-ゼ / ^<15>N標識 / 酵素 / 基質結合部位 / ATP / AMP / ディファレンシャルディスプレイ法 / 内分泌攪乱物質 / 遺伝子発現 / 精巣 / 化学合成DNA / ブレオマイシン / 制がん剤 / アラビノシルC / イノシン / DNA鎖切断機構 / 菌体外分泌 / シグナルペプチド / 蛋白質工学 / ロイシンジッパー / がん遺伝子 / 相互作用 / c-MYC / MAX / がん原遺伝子 / DNA結合蛋白質 / 転写制御因子 / 蛋白質変異体 / DNA-蛋白質相互作用 / proto-oncogene / DNA binding protein / transcription factor / mutant protein / DNA-porotein interaction / structure / ホスファイト法 / Hーホスホネート / リボオリゴヌクレオチド / 固相合成 / アミダイト / ホスホアミダイト / ホスホアミダイト体 / ホスホネート体 / オルトニトロベンジル基 / ホスホロアミダイト体 / Phosphite method / H-Phosphonate / Ribooligonucleotide / solid-phase synthesis / phosphoramidite … More
Except Principal Investigator
NMR / DNA / RNA / リボザイム / 立体構造 / 蛋白質 / 金属イオン / HIV / protein engineering / Mybタンパク質 / タンパク質 / がん遺伝子産物 / X線結晶解析 / 突然変異 / 遺伝子損傷 / 修復酵素 / X線結晶構造解析 / 4重鎖 / 構造生物学 / アデニル酸キナーゼ / タンパク質工学 / pMEX8-hAK1 / adenylate kinase / CD / point mutation / synthetic gene / AMP binding site / DNA結合タンパク質 / ラマン分光 / 高次構造 / DNAの湾曲 / OmpR / RNA化学合成 / 核酸高次構造 / DNA結合蛋白質 / 転写調節 / 触媒RNA / 機能性核酸 / インターカレーター / 核酸ループ / DNAプローブ / DNA給合ドメイン / Myb / ラウエ法 / 時間分割解析 / 蛋白質の構造 / 蛋白質の動的構造 / NMR分光法 / 緩和時間測定 / ケージ化合物 / 神経細胞 / 千重鎖 / ドラッグ / テロメア結合蛋白質 / 発現調節 / 重点領域研究 / 相互作用 / マラリアワクチン / マラリア原虫表皮蛋白質抗原 / モノクロ-ナル抗体Fab / 抗原・抗体および抗原・抗体複合体の結晶化 / H鎖アミノ酸配列 / マラリア原虫表皮蛋白質 / 融合蛋白質抗原 / モノクロ-ナル抗体 / 抗原・抗体複合体 / Malaria vaccine / X-ray structural studies / Repeating amino acid sequence / Circumsporozoite surface protein as antigen / Monoclonal antibodies against circumsporozoite / surface protein / Amino acid Sequence of heavy chain in Fab / 部位特異的変異法 / 基質酵素相互作用 / リジン残基 / キネティックス解析 / ヒトAK1 / pMEX8hAK1 / Adenylate Kinase / Mutagenesis / Protein engineering / site-directed mutagenesis / sabstrate-enzyme interaction / Lysine nesidu / kinetics / human AK1 / アプタマー / Tatタンパク質 / RNA結合タンパク質 / ドラッグデザイン / トリプレットリピート / ダナミクス / テロメア / 安定同位体標識 / 水素結合 / Tat蛋白質 / 蛋白質-RNA相互作用 / aptamer / Tat protein / three-dimensional structure / RNA-binding protein / drug design / 化学合成核酸 / 蛋白質工学 / 基質認識機構 / X線構造解析 / 高分解能NMR / RNaseT1 / オペレーターDNAλO_R3 / 遺伝子発現調節蛋白質λ-cro / ×線構造解析 / RNase【T_1】 / ペプチド鎖延長因子 / 遺伝子発現調節蛋白質 / 核酸の化学合成 / 構造認識 / 構造活性相関 / X線結晶構造 / 2次元NMR / Chemically synthesized nucleic acids / Substrate recognition mechanism / X-ray crystallography / High resolution NMR / RNase Tl / DNA構造の多形 / tRNAの構造と機能 / Hu蛋白質 / Cro蛋白質ヘアピンループの構造 / バルジループの構造 / DNAの分子運動 / X線回析 / tRNA / 制限酵素 / ヘアピンループ / Croリプレッサー / Hu-DNA複合体 / Structures of DNA / Structure and function of tRNA / HU protein / cro repressor / Structure of hairpin loop / Structure of bulge loop / Dynamics of DNA / adenylate Kinase / MgATP Binding site / アデニル酸キナ-ゼ / MgATP結合部位 / アミノ酸点変異 / 人工合成遺伝子 / AMP結合部位 / 合成遺伝子 / 部位特異性変換 / 基質酵素の結合部位 / 筋ジストロフィー症 / プロティンエンジニアリング / MgATP binding site Less
  • Research Projects

    (29 results)
  • Co-Researchers

    (48 People)
  •  Drug design based on the complex structure of HIV-Tat and its RNA aptamer

    • Principal Investigator
      KATAHIRA Masato
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Yokohama National University
  •  カリウムイオンが誘起するDNA4重鎖構造とテロメア配列結合性蛋白質によるその破壊

    • Principal Investigator
      片平 正人
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Yokohama National University
  •  遺伝子発現変導を指標とした内分泌攪乱物質のスクリーニング手法の開発Principal Investigator

    • Principal Investigator
      上杉 晴一
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      Yokohama National University
  •  カリウムイオンによるDNAの構造遷移を利用したリボザイム活性のスイッチング

    • Principal Investigator
      片平 正人
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Yokohama National University
  •  肝炎デルタウィルスRNA型リボザイムの構造と作用機構Principal Investigator

    • Principal Investigator
      上杉 晴一
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Yokohama National University
  •  カリウムが誘導する核酸の新規2重鎖-4重鎖転移及びリボザイムの構造化学的研究

    • Principal Investigator
      片平 正人
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama National University
  •  肝炎デルタウィルスRNA型リボザイムの構造と作用機構Principal Investigator

    • Principal Investigator
      上杉 晴一
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama National University
  •  Structure and properties of Max protein which regulates the function of a proto-oncogene product, c-MycPrincipal Investigator

    • Principal Investigator
      UESUGI Seiichi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Yokohama National University
  •  亜鉛フィンガー蛋白質EIAと鉛リボザイムの生理機能発現機構の構造化学的研究

    • Principal Investigator
      KATAHIRA Masato
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama National University
  •  "The molecular and pathological studies on adenylate kinase"

    • Principal Investigator
      HAMADA Minoru
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hygiene
    • Research Institution
      Miyazaki Medical College
  •  機能の創生を目指すオリゴヌクレオチドの化学合成

    • Principal Investigator
      大塚 栄子
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  時間分割ラウエ法利用研究

    • Principal Investigator
      三井 幸雄
    • Project Period (FY)
      1993 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagaoka University of Technology
  •  肝炎デルタウィルスRNAリボザイム活性ドメインの構造研究Principal Investigator

    • Principal Investigator
      上杉 晴一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama National University
  •  遺伝子損傷と突然変異の分子基盤

    • Principal Investigator
      早津 彦哉
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Okayama University
  •  蛋白質が認識するDNA構造

    • Principal Investigator
      西村 善文
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  遺伝子損傷と突然変異の分子基盤

    • Principal Investigator
      早津 彦哉
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Okayama University
  •  STRUCTURAL STUDY OF INTERACTION BETWEEN c-MYC PROTEIN AND ITS TARGET DNA OLIGOMER BY NMRPrincipal Investigator

    • Principal Investigator
      UESUGI Seiichi
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      YOKOHAMA NATIONAL UNIVERSITY
  •  機能の創生を目指すオリゴヌクレオチドの化学合成

    • Principal Investigator
      OHTSUKA Eiko
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  蛋白質が認識するDNA構造

    • Principal Investigator
      西村 善文
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  ^<15>N標識および変異体を利用したNMRによる酵素の作用機構の研究Principal Investigator

    • Principal Investigator
      上杉 晴一
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University
  •  蛋白質が認識するDNA構造

    • Principal Investigator
      NISHIMURA Yoshifumi
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Yokohama City University
  •  X-ray Structural Studies of Antigen-Antibody Complex Toward Malaria Vaccine Development.

    • Principal Investigator
      TOMITA Ken-ichi
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Osaka University
  •  蛋白質工学によるc-myc遺伝子産物の構造と機能の研究Principal Investigator

    • Principal Investigator
      上杉 晴一
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  発現調節の分子論的解析

    • Principal Investigator
      京極 好正
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      分子遺伝学・分子生理学
    • Research Institution
      Osaka University
  •  Pathogenetic investigations for human Duchenne muscular dystrophy-Adenylate kinase as a molecular marker-

    • Principal Investigator
      HAMADA Minoru
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hygiene
    • Research Institution
      宮崎医科大学
  •  Versatality of Nucleic Acid Structure and its recognition

    • Principal Investigator
      SHINDO Heisaburo
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      生物物性学
    • Research Institution
      Tokyo College of Pharmacy
  •  A New Synthetic Method for Oligoribonucleotides by the Phosphite Triester ApproachPrincipal Investigator

    • Principal Investigator
      UESUGI Seiichi
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Osaka University
  •  DNA鎖を切断する制がん抗生物質の作用の分子機構の研究Principal Investigator

    • Principal Investigator
      上杉 晴一
    • Project Period (FY)
      1985
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  Expression of Chemically synthetic genes and structure-functon relationship of their proteins

    • Principal Investigator
      IKEHARA Morio
    • Project Period (FY)
      1984 – 1987
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Research Institution
      Science University of Tokyo
      Osaka University
  • 1.  KYOGOKU Toshimasa (90012632)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 2.  NISHIMURA Yoshifumi (70107390)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  KATAHIRA Masato (70211844)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  SHINDO Heisaburo (80138966)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  OHTSUKA Eiko (80028836)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  KURIHARA Yasuyuki (80202050)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  水野 猛 (10174038)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  HAKOSHIMA. Toshio (00164773)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  TANAKA Toshiki (70171775)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  NISHIKAWA Satoshi (70150307)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  TOMITA Ken-ichi (30028831)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  HAMADA Minoru (90039529)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  TAKENAKA Hitoshi (10179658)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  高久 洋 (50101267)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  牧野 圭祐 (50159141)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  甲斐荘 正恒 (20137029)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  早津 彦哉 (10012593)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  綿矢 有佑 (90127598)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 19.  根岸 和雄 (70116490)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 20.  菊川 清見 (90120146)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 21.  金沢 浩 (50116448)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 22.  HORII Toshihiro (80142305)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  OMATA Yoshitaka (10132987)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  YAMAGATA Yuriko (40183678)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  FUJII Satoshi (10107104)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  IKEHARA Morio (10028821)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  NISHIKAWA Kazuya (60109262)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  YOKOYAMA Shigeyuki (00159229)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  陶山 明 (90163063)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  松本 治 (10231599)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  竹中 章郎 (80016146)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  三井 幸雄 (40012637)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  田之倉 優 (60136786)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  西野 武士 (40094312)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  森島 績 (50026093)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  小田 順一 (50027041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  平田 文男 (90218785)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  倉光 成紀 (60153368)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  楯 真一 (20216998)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  勝部 幸輝 (20032013)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  鈴木 理 (70187764)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  嶋本 伸雄 (20127658)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  饗場 弘二 (20025662)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  ARMAH George E.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  POLJAK Roberto J.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  AKANMORI Bar
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  AKANMORI Barthoromew D.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  POLJAK Robe
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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