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UESUGI Seiichi
上杉 晴一
Connect your ORCID iD
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Researcher Number
70028851
Other IDs
External Links
Affiliation (based on the past Project Information)
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2002: 横浜国立大学, 大学院・環境情報研究科, 教授
2001 – 2002: 横浜国立大学, 大学院・環境情報研究院, 教授
1991 – 2000: Associate Professor, Faculty of Pharmaceutical Sciences, Osaka University. (Pres, 工学部, 教授
1993: 東京工業大学, 生命理工学部, 教授
1986 – 1991: 大阪大学, 薬学部, 助教授
…
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1987 – 1988: 大阪大学, 薬学部・薬化学, 助教授
1986: 阪大, 薬学部, 助教授
1985: 大阪大学, 薬, 助教授
Less
Review Section/Research Field
Principal Investigator
Physical pharmacy
/
環境影響評価(含放射線生物学)
/
Chemical pharmacy
Except Principal Investigator
Biological pharmacy
/
Hygiene
/
分子遺伝学・分子生理学
/
Physical pharmacy
/
生物物性学
Keywords
Principal Investigator
NMR / 構造 / RNA / リボザイム / c-Myc / Max / タンパク質 / 肝炎デルタウィルス / 分子生物学 / 金属酵素
…
More
/ CD / c-myc / 蛋白質 / 遺伝子工学 / DNA / アデニレ-トキナ-ゼ / ^<15>N標識 / 酵素 / 基質結合部位 / ATP / AMP / ディファレンシャルディスプレイ法 / 内分泌攪乱物質 / 遺伝子発現 / 精巣 / 化学合成DNA / ブレオマイシン / 制がん剤 / アラビノシルC / イノシン / DNA鎖切断機構 / 菌体外分泌 / シグナルペプチド / 蛋白質工学 / ロイシンジッパー / がん遺伝子 / 相互作用 / c-MYC / MAX / がん原遺伝子 / DNA結合蛋白質 / 転写制御因子 / 蛋白質変異体 / DNA-蛋白質相互作用 / proto-oncogene / DNA binding protein / transcription factor / mutant protein / DNA-porotein interaction / structure / ホスファイト法 / Hーホスホネート / リボオリゴヌクレオチド / 固相合成 / アミダイト / ホスホアミダイト / ホスホアミダイト体 / ホスホネート体 / オルトニトロベンジル基 / ホスホロアミダイト体 / Phosphite method / H-Phosphonate / Ribooligonucleotide / solid-phase synthesis / phosphoramidite
…
More
Except Principal Investigator
NMR / DNA / RNA / リボザイム / 立体構造 / 蛋白質 / 金属イオン / HIV / protein engineering / Mybタンパク質 / タンパク質 / がん遺伝子産物 / X線結晶解析 / 突然変異 / 遺伝子損傷 / 修復酵素 / X線結晶構造解析 / 4重鎖 / 構造生物学 / アデニル酸キナーゼ / タンパク質工学 / pMEX8-hAK1 / adenylate kinase / CD / point mutation / synthetic gene / AMP binding site / DNA結合タンパク質 / ラマン分光 / 高次構造 / DNAの湾曲 / OmpR / RNA化学合成 / 核酸高次構造 / DNA結合蛋白質 / 転写調節 / 触媒RNA / 機能性核酸 / インターカレーター / 核酸ループ / DNAプローブ / DNA給合ドメイン / Myb / ラウエ法 / 時間分割解析 / 蛋白質の構造 / 蛋白質の動的構造 / NMR分光法 / 緩和時間測定 / ケージ化合物 / 神経細胞 / 千重鎖 / ドラッグ / テロメア結合蛋白質 / 発現調節 / 重点領域研究 / 相互作用 / マラリアワクチン / マラリア原虫表皮蛋白質抗原 / モノクロ-ナル抗体Fab / 抗原・抗体および抗原・抗体複合体の結晶化 / H鎖アミノ酸配列 / マラリア原虫表皮蛋白質 / 融合蛋白質抗原 / モノクロ-ナル抗体 / 抗原・抗体複合体 / Malaria vaccine / X-ray structural studies / Repeating amino acid sequence / Circumsporozoite surface protein as antigen / Monoclonal antibodies against circumsporozoite / surface protein / Amino acid Sequence of heavy chain in Fab / 部位特異的変異法 / 基質酵素相互作用 / リジン残基 / キネティックス解析 / ヒトAK1 / pMEX8hAK1 / Adenylate Kinase / Mutagenesis / Protein engineering / site-directed mutagenesis / sabstrate-enzyme interaction / Lysine nesidu / kinetics / human AK1 / アプタマー / Tatタンパク質 / RNA結合タンパク質 / ドラッグデザイン / トリプレットリピート / ダナミクス / テロメア / 安定同位体標識 / 水素結合 / Tat蛋白質 / 蛋白質-RNA相互作用 / aptamer / Tat protein / three-dimensional structure / RNA-binding protein / drug design / 化学合成核酸 / 蛋白質工学 / 基質認識機構 / X線構造解析 / 高分解能NMR / RNaseT1 / オペレーターDNAλO_R3 / 遺伝子発現調節蛋白質λ-cro / ×線構造解析 / RNase【T_1】 / ペプチド鎖延長因子 / 遺伝子発現調節蛋白質 / 核酸の化学合成 / 構造認識 / 構造活性相関 / X線結晶構造 / 2次元NMR / Chemically synthesized nucleic acids / Substrate recognition mechanism / X-ray crystallography / High resolution NMR / RNase Tl / DNA構造の多形 / tRNAの構造と機能 / Hu蛋白質 / Cro蛋白質ヘアピンループの構造 / バルジループの構造 / DNAの分子運動 / X線回析 / tRNA / 制限酵素 / ヘアピンループ / Croリプレッサー / Hu-DNA複合体 / Structures of DNA / Structure and function of tRNA / HU protein / cro repressor / Structure of hairpin loop / Structure of bulge loop / Dynamics of DNA / adenylate Kinase / MgATP Binding site / アデニル酸キナ-ゼ / MgATP結合部位 / アミノ酸点変異 / 人工合成遺伝子 / AMP結合部位 / 合成遺伝子 / 部位特異性変換 / 基質酵素の結合部位 / 筋ジストロフィー症 / プロティンエンジニアリング / MgATP binding site
Less
Research Projects
(
29
results)
Co-Researchers
(
48
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Drug design based on the complex structure of HIV-Tat and its RNA aptamer
Principal Investigator
KATAHIRA Masato
Project Period (FY)
2000 – 2002
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Physical pharmacy
Research Institution
Yokohama National University
カリウムイオンが誘起するDNA4重鎖構造とテロメア配列結合性蛋白質によるその破壊
Principal Investigator
片平 正人
Project Period (FY)
1999
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
Yokohama National University
遺伝子発現変導を指標とした内分泌攪乱物質のスクリーニング手法の開発
Principal Investigator
Principal Investigator
上杉 晴一
Project Period (FY)
1999
Research Category
Grant-in-Aid for Exploratory Research
Research Field
環境影響評価(含放射線生物学)
Research Institution
Yokohama National University
カリウムイオンによるDNAの構造遷移を利用したリボザイム活性のスイッチング
Principal Investigator
片平 正人
Project Period (FY)
1998
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
Yokohama National University
肝炎デルタウィルスRNA型リボザイムの構造と作用機構
Principal Investigator
Principal Investigator
上杉 晴一
Project Period (FY)
1998
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (A)
Research Institution
Yokohama National University
カリウムが誘導する核酸の新規2重鎖-4重鎖転移及びリボザイムの構造化学的研究
Principal Investigator
片平 正人
Project Period (FY)
1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Yokohama National University
肝炎デルタウィルスRNA型リボザイムの構造と作用機構
Principal Investigator
Principal Investigator
上杉 晴一
Project Period (FY)
1997
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Yokohama National University
Structure and properties of Max protein which regulates the function of a proto-oncogene product, c-Myc
Principal Investigator
Principal Investigator
UESUGI Seiichi
Project Period (FY)
1997 – 1999
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Physical pharmacy
Research Institution
Yokohama National University
亜鉛フィンガー蛋白質EIAと鉛リボザイムの生理機能発現機構の構造化学的研究
Principal Investigator
KATAHIRA Masato
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Yokohama National University
"The molecular and pathological studies on adenylate kinase"
Principal Investigator
HAMADA Minoru
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Hygiene
Research Institution
Miyazaki Medical College
機能の創生を目指すオリゴヌクレオチドの化学合成
Principal Investigator
大塚 栄子
Project Period (FY)
1993
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Hokkaido University
時間分割ラウエ法利用研究
Principal Investigator
三井 幸雄
Project Period (FY)
1993 – 1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Nagaoka University of Technology
肝炎デルタウィルスRNAリボザイム活性ドメインの構造研究
Principal Investigator
Principal Investigator
上杉 晴一
Project Period (FY)
1993
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Yokohama National University
遺伝子損傷と突然変異の分子基盤
Principal Investigator
早津 彦哉
Project Period (FY)
1993
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
Biological pharmacy
Research Institution
Okayama University
蛋白質が認識するDNA構造
Principal Investigator
西村 善文
Project Period (FY)
1992
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Yokohama City University
遺伝子損傷と突然変異の分子基盤
Principal Investigator
早津 彦哉
Project Period (FY)
1992
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
Biological pharmacy
Research Institution
Okayama University
STRUCTURAL STUDY OF INTERACTION BETWEEN c-MYC PROTEIN AND ITS TARGET DNA OLIGOMER BY NMR
Principal Investigator
Principal Investigator
UESUGI Seiichi
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Physical pharmacy
Research Institution
YOKOHAMA NATIONAL UNIVERSITY
機能の創生を目指すオリゴヌクレオチドの化学合成
Principal Investigator
OHTSUKA Eiko
Project Period (FY)
1991
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Hokkaido University
蛋白質が認識するDNA構造
Principal Investigator
西村 善文
Project Period (FY)
1991
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Yokohama City University
^<15>N標識および変異体を利用したNMRによる酵素の作用機構の研究
Principal Investigator
Principal Investigator
上杉 晴一
Project Period (FY)
1991
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Physical pharmacy
Research Institution
Osaka University
蛋白質が認識するDNA構造
Principal Investigator
NISHIMURA Yoshifumi
Project Period (FY)
1990
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
Yokohama City University
X-ray Structural Studies of Antigen-Antibody Complex Toward Malaria Vaccine Development.
Principal Investigator
TOMITA Ken-ichi
Project Period (FY)
1989 – 1991
Research Category
Grant-in-Aid for international Scientific Research
Research Institution
Osaka University
蛋白質工学によるc-myc遺伝子産物の構造と機能の研究
Principal Investigator
Principal Investigator
上杉 晴一
Project Period (FY)
1988
Research Category
Grant-in-Aid for Cancer Research
Research Institution
Osaka University
発現調節の分子論的解析
Principal Investigator
京極 好正
Project Period (FY)
1988
Research Category
Grant-in-Aid for Co-operative Research (B)
Research Field
分子遺伝学・分子生理学
Research Institution
Osaka University
Pathogenetic investigations for human Duchenne muscular dystrophy-Adenylate kinase as a molecular marker-
Principal Investigator
HAMADA Minoru
Project Period (FY)
1987 – 1989
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Hygiene
Research Institution
宮崎医科大学
Versatality of Nucleic Acid Structure and its recognition
Principal Investigator
SHINDO Heisaburo
Project Period (FY)
1986 – 1987
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
生物物性学
Research Institution
Tokyo College of Pharmacy
A New Synthetic Method for Oligoribonucleotides by the Phosphite Triester Approach
Principal Investigator
Principal Investigator
UESUGI Seiichi
Project Period (FY)
1986 – 1988
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Chemical pharmacy
Research Institution
Osaka University
DNA鎖を切断する制がん抗生物質の作用の分子機構の研究
Principal Investigator
Principal Investigator
上杉 晴一
Project Period (FY)
1985
Research Category
Grant-in-Aid for Cancer Research
Research Institution
Osaka University
Expression of Chemically synthetic genes and structure-functon relationship of their proteins
Principal Investigator
IKEHARA Morio
Project Period (FY)
1984 – 1987
Research Category
Grant-in-Aid for Specially Promoted Research
Research Institution
Science University of Tokyo
Osaka University
# of Projects (Dsc)
# of Projects (Asc)
1.
KYOGOKU Toshimasa
(90012632)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
2.
NISHIMURA Yoshifumi
(70107390)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
3.
KATAHIRA Masato
(70211844)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
4.
SHINDO Heisaburo
(80138966)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
5.
OHTSUKA Eiko
(80028836)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
6.
KURIHARA Yasuyuki
(80202050)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
7.
水野 猛
(10174038)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
8.
HAKOSHIMA. Toshio
(00164773)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
9.
TANAKA Toshiki
(70171775)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
10.
NISHIKAWA Satoshi
(70150307)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
TOMITA Ken-ichi
(30028831)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
HAMADA Minoru
(90039529)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
13.
TAKENAKA Hitoshi
(10179658)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
高久 洋
(50101267)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
15.
牧野 圭祐
(50159141)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
16.
甲斐荘 正恒
(20137029)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
17.
早津 彦哉
(10012593)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
18.
綿矢 有佑
(90127598)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
19.
根岸 和雄
(70116490)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
20.
菊川 清見
(90120146)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
21.
金沢 浩
(50116448)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
22.
HORII Toshihiro
(80142305)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
OMATA Yoshitaka
(10132987)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
YAMAGATA Yuriko
(40183678)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
FUJII Satoshi
(10107104)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
IKEHARA Morio
(10028821)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
NISHIKAWA Kazuya
(60109262)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
YOKOYAMA Shigeyuki
(00159229)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
陶山 明
(90163063)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
松本 治
(10231599)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
竹中 章郎
(80016146)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
三井 幸雄
(40012637)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
田之倉 優
(60136786)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
西野 武士
(40094312)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
森島 績
(50026093)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
36.
小田 順一
(50027041)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
37.
平田 文男
(90218785)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
38.
倉光 成紀
(60153368)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
39.
楯 真一
(20216998)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
40.
勝部 幸輝
(20032013)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
41.
鈴木 理
(70187764)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
42.
嶋本 伸雄
(20127658)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
43.
饗場 弘二
(20025662)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
44.
ARMAH George E.
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
45.
POLJAK Roberto J.
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
46.
AKANMORI Bar
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
47.
AKANMORI Barthoromew D.
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
48.
POLJAK Robe
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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