ASANO Takao 浅野孝雄

… Alternative Names

浅野孝雄アサノタカオ

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Researcher Number	70090496
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2009: 埼玉医科大学, 医学部, 客員教授 2002 – 2006: 埼玉医科大学, 医学部, 教授 1999: Saitama Medical School, Medicine, Professor, 医学部, 教授 1998: 埼玉医科大学, 医学部・脳神経外科, 教授 1997: 埼玉医科大学, 医学部, 教授 … More 1994 – 1995: 埼玉医科大学, 医学部, 教授 1994: Saitama Medical School Medical Center Professor, 総合医療センター, 教授 1992: 埼玉医科大学, 総合医療センター, 教授 1986: Tokyo University, Department of Neurosurgery, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Cerebral neurosurgery Except Principal Investigator Cerebral neurosurgery / 麻酔学 / Nerve anatomy/Neuropathology
Keywords	Principal Investigator 脳虚血 / Cerebral Ischemia / S-100 / Free Radical Scavengers / Lipid Peroxidation / Na,K-ATPase / Free Radicals / Arachidonate Cascade / Brain Edema / 脳微小血管 … More / 血液脳関門 / 過酸化脂質 / リポキシゲナーゼ / 遊離基 / アラキドン酸カスケード / 脳浮腫 / Astrocyte / Rat / Permanent focal cerebral ischemia / 永久局所脳虚血モデル / アストロサイト / S-100蛋白 / 永久脳虚血モデル / アストロサイ / ラット / 永久局所脳虚血 / neuroprotection / transient brain hypothermia / permanent focal cerebral ischemia / 低体温療法 / 脳梗塞 / 一時的脳虚血 / 永久脳虚血 / 復温障害 / 神経保護 / 脳保護 / 一過性脳冷却 / 局所永久脳虚血 / chronic vasospasm / pressure-diameter curve / basilar artery / mechanical property / プロテインカイネースC / 血管径曲線 / 血管内圧 / ビデオシステム / 脳血管攣縮 / 脳血管 / 血管平滑筋 / video-system / active tonus … More Except Principal Investigator Astrocyte / Isoform specific / Knock-in mouse / subacute cerebral ischemia / Acute / Apolipoprotein E / 急性期脳虚血 / アポリポプロテインE / アストロサイト / アイソフォーム特異的 / ノックインマウス / 急性期・亜急性期脳虚血 / アポリポプロテイン E / Nitric oxide / cDNA subtraction / Calcium binding protein / NMDA receptor / Calcium channel / Long term potentiation / Intracellular calcium / Brain ischemia / 海馬 / 脳損傷 / 海馬スライス / アラキドン酸代謝系 / NO / NMDAレセプタ / 一酸化窒素 / cDNAサブトラクション法 / カルシウム結合タンパク / NMDAレセプター / カルシウムチャネル / 長期増強 / 細胞内カルシウム / 脳虚血 / 病理学 / 脳神経疾患 / 獣医学 / 細胞・組織 / 神経病理学 / 脳神経変性疾患 / 神経科学 Less

Possible role of glial cells in the progression of Alzheimer's disease pathology
- Principal Investigator
  
  MORI Takashi
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Saitama Medical University
Comparison of apolipoprotein E isoform-specific effects after experimental cerebral ischemia.
- Principal Investigator
  
  MORI Takashi
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Saitama Medical School
Possible role of astrocytes in the disease progression of experimental cerebral ischemiaPrincipal Investigator
- Principal Investigator
  
  ASANO Takao
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Saitama Medical University
Neuroprotective effects of the hypothermia on permanent and transient cerebral ischemiaPrincipal Investigator
- Principal Investigator
  
  ASANO Takao
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Saitama Medical School
Research on differences in mechanical property between normal and spastic arterial wall.Principal Investigator
- Principal Investigator
  
  ASANO Takao
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  SAITMA MEDICAL SCHOOL
Pathophysiology and treatments of brain ischemia insighted from neuronal function, metabolism and molecular structure
- Principal Investigator
  
  SHIMOJI Koki
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  麻酔学
- Research Institution
  Niigata University
Investigation on a novel therapeutic agent against ischemic brain edema.Principal Investigator
- Principal Investigator
  
  ASANO Takao
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tokyo University

All 2007 2006 2005 2004 2003 2002

All Journal Article Presentation Book

[Book] The role of glia in neurotoxicity(Aschner M, Costa LG ed.,)2005
- Author(s)
  Asano T・・・ Mori T et al.
- Publisher
  CRC press L.L.C., (Boca Raton)
- Data Source
  KAKENHI-PROJECT-14571329
[Book] The role of glia in neurotoxicity(Aschner M and Costa LG ed.)2005
- Author(s)
  Asano T et al.
- Publisher
  CRC press L.L.C., (Boca Raton)
- Data Source
  KAKENHI-PROJECT-14571330
[Book] Role of astrocytes in medication of stroke : Possible detrimental role of astrocytic activation during the subacute phase of permanent focal cerebral ischemia in the rat (The role of glia in neurotoxicity) (Aschner M and Costa LG ed.)2005
- Author(s)
  Asano T, Mori T
- Publisher
  CRC press L.L.C., (Boca Raton)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Book] The role of glia in neurotoxicity(Aschner M and Costa LG ed.)2005
- Author(s)
  Asano T., Mori T., et al.
- Publisher
  CRC press L.L.C., (Boca Raton)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Book] The role of glia in neurotoxicity2005
- Author(s)
  Asano T, Mori T et al.
- Publisher
  Aschner M and Costa LG ed., CRC press L.L.C., (Boca Rat on)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Book] Role of astrocytes in medication of stroke : Possible detrimental role of astrocytic activation during the subacute phase of permanent focal cerebral ischemia in the rat. In The role of glia in neurotoxicity, (Aschner M and Costa LG ed.)2005
- Author(s)
  Asano T, Tateishi N, Mori T.
- Publisher
  CRC press L.L.C. (Boca Raton)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Book] Molecular mechanism and epochal therapeutics of ischemic stroke and dementia(Abe K ed.)2003
- Author(s)
  Asano T., Mori T., et al.
- Publisher
  Elesvier Science Publishers B.V., (Amsterdam)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Book] Molecular mechanism and epochal therapeutics of ischemic stroke and dementia(Abe K ed.)2003
- Author(s)
  Asano T et al.
- Publisher
  Elsevier Science Publishers B.V., (Amsterdam)
- Data Source
  KAKENHI-PROJECT-14571330
[Book] Functional modulation of astrocytes by a novel agent ONO-2506 mitigates delayed infarct expansion with a wide therapeutic time window, inducing prompt neurological recovery through reduction of the extracellular level of glutamate (Molecular mechanism and epochal therapeutics of ischemic stroke and dementia) (Abe K ed.)2003
- Author(s)
  Asano T, Mori T et al.
- Publisher
  Elsevier Science Publishers B.V., (Amsterdam)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice.2006
- Author(s)
  Takashi Mori, Terrence Town, Jun Tan, Nobumichi Yada, Yuko Horikoshi, Junki Yamamoto, Taiji Shimoda, Yoshihisa Kamanaka, Narito Tateishi, Takao Asano
- Journal Title
  
  J Pharmacol Exp Ther 318(2)
  
  Pages: 571-578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500279
[Journal Article] Arundic acid (ONO-2506) ameliorates ischemic brain damage by preventing astrocytic overproduction of S100B2005
- Author(s)
  Asano T, Mori T. et al.
- Journal Title
  
  Curr Drug Targets- CNS & Neurologic Disord (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Arundic acid (ONO-2506) ameliorates ischemic brain damage by preventing astrocytic overproduction of S100B.2005
- Author(s)
  Asano T et al.
- Journal Title
  
  Current Drug Targets-CNS & Neurologic Disorder (In press)
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Arundic acid (ONO-2506) ameliorates ischemic brain damage by preventing astrocytic overproduction of S100B.2005
- Author(s)
  Asano T, Mori T, Shimoda T, Shinagawa R, Satoh S, Yada N, Katsumata S, Matsuda S, Kagamiishi Y, Tateishi N.
- Journal Title
  
  Curr Drug Targets- CNS & Neurologic Disord 4(2)
  
  Pages: 127-142
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Apolipoprotein E isoform and ischemic brain injury.2005
- Author(s)
  Mori T, Asano T.
- Journal Title
  
  Cerebral Blood Flow and Metabolism 17(1)
  
  Pages: 61-67
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice.2005
- Author(s)
  Mori T, Town T, Tan J, Tateishi N, Asano T.
- Journal Title
  
  J Cereb Blood Flow and Metab 25(6)
  
  Pages: 748-762
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Arundic acid (ONO-2506) ameliorates ischemic brain damage by preventing astrocytic overproduction of S100B.2005
- Author(s)
  Asano T, Mori T et al.
- Journal Title
  
  Curr Drug Targets-CNS & Neurologic Disord 4(2)
  
  Pages: 127-142
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Arundic acid (ONO-2506) ameliorates ischemic brain damage by preventing astrocytic overproduction of S100B.2005
- Author(s)
  Asano T, Mori T... et al.
- Journal Title
  
  Current Drug Targets-CNS & Neurologic Disorder 4(2)
  
  Pages: 127-142
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Apolipoprotein E isoform and ischemic brain injury.2005
- Author(s)
  Mori T, Asano T
- Journal Title
  
  Cerebral Blood Flow and Metabolism 17(1)
  
  Pages: 61-67
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Arundic acid (ONO-2506) ameliorates ischemic brain damage by preventing astrocytic overproduction of S100B.2005
- Author(s)
  Asano T, Mori T, et al.
- Journal Title
  
  Current Drug Targets-CNS & Neurologic Disorder (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Apolipoprotein E isoform and ischemic brain injury.2005
- Author(s)
  Mori T, Asano T
- Journal Title
  
  Cerebral Blood Flow and Metabolism 17 (1)
  
  Pages: 61-67
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Augmented delayed infarct expansion and reactive astrocytosis after permanent focal ischemia in apolipoprotein E4 knock-in mice.2004
- Author(s)
  Mori T, Town T, Kobayashi M, Tan J, Fujita SC, Asano T.
- Journal Title
  
  J Cereb Blood Flow and Metab 24(6)
  
  Pages: 646-656
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Attenuation of a delayed increase in the extracellular glutamate level in the peri-infarct area following focal cerebral ischemia by a novel agent ONO-2506.2004
- Author(s)
  Mori T., Asano T
- Journal Title
  
  Neurochem Int 45(2-3)
  
  Pages: 381-387
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Attenuation of a delayed increase in the extracellular glutamate level in the peri-infarct area following focal cerebral ischemia by a novel agent ONO-25062004
- Author(s)
  Mori T, Asano T
- Journal Title
  
  Neurochem Int 45(2-3)
  
  Pages: 381-387
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice.2003
- Author(s)
  Mori T......Asano T
- Journal Title
  
  Journal of Neuropathology and Experimental Neurology 62
  
  Pages: 280-291
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice.2003
- Author(s)
  Mori T, Kobayashi M, Town T, Fujita SC, Asano T.
- Journal Title
  
  J Neuropathol Exp Neurol 62(3)
  
  Pages: 280-291
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571329
[Journal Article] Astrocytic activation and delayed infarct expansion following permanent focal ischemia in rats. Part II : Suppression of astrocytic activation by a novel agent (R)-(-)-2 propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurological deficits2002
- Author(s)
  Tateishi N, Mori T, Morikawa E, Asano T
- Journal Title
  
  J Cereb Blood Flow and Metab 22(6)
  
  Pages: 723-734
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Astrocytic activation and delayed infarct expansion fdlowing permanent focal ischemia in rats. Part I : Enhanced astrocytic synthesis of S-100β in the periinfarct area precedes the occurrence of delayed infarct expansion.2002
- Author(s)
  Matsui T., Mori T., Morikawa E., Asano T
- Journal Title
  
  J Cereb Blood Flow and Metab 22(6)
  
  Pages: 711-722
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Astrocytic activation and delayed infarct expansion following permanent focal ischemia in rats. Part II : Suppression of astrocytic activation by a novel agent (R)-(-)-2 propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early improvement of neurological deficits.2002
- Author(s)
  Tateishi N, Mori T, Morikawa E, Asano T
- Journal Title
  
  J Cereb Blood Flow and Metab 22(6)
  
  Pages: 723-734
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Journal Article] Astrocytic activation and delayed infarct expansion following permanent focal ischemia in rats. Part I : Enhanced astrocytic synthesis of S- 100β in the periinfarct area precedes the occurrence of delayed infarct expansion2002
- Author(s)
  Matsui T, Mori T, Morikawa E, Asano T
- Journal Title
  
  J Cereb Blood Flow and Metab 22(6)
  
  Pages: 711-722
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571330
[Presentation] A new therapeutic agent for Alzheimer disease: Arundic acid (ONO-2506) attenuates cerebral amyloidosis and gliosis in Alzheimer transgenic mice.2007
- Author(s)
  Takashi Mori, Terrence Town, Jun Tan, Nobumichi Yada, Junki Yamamoto, Masamitsu Hoshikawa, Rika Shinagawa, Yoshihisa Kamanaka, Naoki Koyama, Takao Asano.
- Organizer
  International Psychogeriatric Association (IPA) 2007 Osaka Silver Congress
- Place of Presentation
  Osaka, Japan
- Year and Date
  2007-10-17
- Data Source
  KAKENHI-PROJECT-18500279
[Presentation] A new therapeutic agent for Alzheimer disease : Arundic acid (ONO-2506) attenuates cerebral amyloidosis and gliosis in Alzheimer transgenic mice2007
- Author(s)
  Takashi Mori, Terrence Town, Jun Tan, Nobumichi Yada, Junki Yamamoto, Masamitsu Hoshikawa, Rika Shinagawa, Yoshihisa Kamanaka, Naoki Koyama, Takao Asano
- Organizer
  International Psychogeriatric Association (IPA) 2007 Osaka Silver Congress
- Place of Presentation
  Osaka, Japan
- Data Source
  KAKENHI-PROJECT-18500279

1. MORI Takashi (60239605)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
2. MORIKAWA Eiharu (90251256)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. KAIZU Hiroyuki (30204308)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. MATSUI Toru (70199735)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMAGUCHI Haruyasu (00158114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHIMOJI Koki (30040158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HIGASHI Hideho (10098907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SATOH Masamichi (80025709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KUMANISHI Toshiro (40018601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. AKAIKE Norio (30040182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ITOH Shouichi (50223152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MORIMOTO Tadashi (20230154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TANI UCHI Tamiki (30275888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KANEKO Mikiko (90177527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HANAMURA Tetsu (20091077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAKU Shigeno (20170863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 崎村建司 (40162325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 佐武明 (70018589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 井下田格

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ASANO Takao 浅野 孝雄

浅野 孝雄 アサノ タカオ

Research Projects

Research Products

Co-Researchers

Possible role of glial cells in the progression of Alzheimer's disease pathology

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comparison of apolipoprotein E isoform-specific effects after experimental cerebral ischemia.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Possible role of astrocytes in the disease progression of experimental cerebral ischemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neuroprotective effects of the hypothermia on permanent and transient cerebral ischemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on differences in mechanical property between normal and spastic arterial wall.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathophysiology and treatments of brain ischemia insighted from neuronal function, metabolism and molecular structure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation on a novel therapeutic agent against ischemic brain edema.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] The role of glia in neurotoxicity(Aschner M, Costa LG ed.,)2005

Author(s)

Publisher

Data Source

[Book] The role of glia in neurotoxicity(Aschner M and Costa LG ed.)2005

Author(s)

Publisher

Data Source

[Book] Role of astrocytes in medication of stroke : Possible detrimental role of astrocytic activation during the subacute phase of permanent focal cerebral ischemia in the rat (The role of glia in neurotoxicity) (Aschner M and Costa LG ed.)2005

Author(s)

Publisher

Description

Data Source

[Book] The role of glia in neurotoxicity(Aschner M and Costa LG ed.)2005

Author(s)

Publisher

Description

Data Source

[Book] The role of glia in neurotoxicity2005

Author(s)

Publisher

Description

Data Source

[Book] Role of astrocytes in medication of stroke : Possible detrimental role of astrocytic activation during the subacute phase of permanent focal cerebral ischemia in the rat. In The role of glia in neurotoxicity, (Aschner M and Costa LG ed.)2005

Author(s)

Publisher

Description

Data Source

[Book] Molecular mechanism and epochal therapeutics of ischemic stroke and dementia(Abe K ed.)2003

Author(s)

Publisher

Description

Data Source

ASANO Takao 浅野孝雄

浅野孝雄アサノタカオ