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Iwama Atsushi  岩間 厚志

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IWAMA Atsushi  岩間 厚志

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Researcher Number 70244126
Other IDs
External Links
Affiliation (Current) 2025: 東京大学, 医科学研究所, 教授
Affiliation (based on the past Project Information) *help 2018 – 2024: 東京大学, 医科学研究所, 教授
2015 – 2017: 千葉大学, 大学院医学研究院, 教授
2011 – 2015: 千葉大学, 医学(系)研究科(研究院), 教授
2014: 千葉大学, 大学院医学研究科, 教授
2013: 千葉大学, 大学院医学研究院, 教授 … More
2007 – 2012: Chiba University, Graduate School of Medicine, Professor
2008: Chiba University, 大学院・医学研究院, 教授
2008: 千葉大学, 大学院医学研究院, 教授
2006: 千葉大学, 大学院医学研究院, 教授
2005: Chiba University, Graduate School Medicine, Professor, 大学院・医学研究院, 教授
2005: 千葉大学, 大学院・医学系研究院, 教授
2004: 東京大学, 医科学研究, 講師
2002 – 2004: 東京大学, 医科学研究所, 講師
2003: 東京大学, 医科学研究科, 講師
2000 – 2001: 筑波大学, 基礎医学系, 講師
1997: Kumamoto University School of Medicine, Research Associate
1996: 熊本大学, 医学部, 助手
1993 – 1994: 熊本大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Hematology / Biological Sciences / Hematology / Broad Section I / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / 内科学一般
Except Principal Investigator
Hematology / Hematology / Gastroenterology … More / Biological Sciences / 内科学一般 / Broad Section I / Biological Sciences / Plastic surgery Less
Keywords
Principal Investigator
造血幹細胞 / Bmi1 / エピジェネティクス / ポリコーム遺伝子 / エイジング / 幹細胞 / 自己複製 / C / 造血器腫瘍 / EBP … More / 加齢 / 老化 / ステムセルエイジング / 骨髄異形成症候群 / Bmil / 白血病幹細胞 / Dmap1 / 造血腫瘍 / self-renewal / hematopoietic stem cell / 疾患 / ポリコーム群複合体 / ポリコーム群遺伝子 / STAT5 / 骨髄球分化 / RFX / 受容体型チロシンキナーゼ / polycomb group gene / STAT3 / GATA-1 / MLL-AF9 / lincRNA / ポリコーム複合体 / Dnmt1 / DNAメチル化 / Bmi-1 / 精子幹細胞 / TMTSP / Endomucin / 樹状細胞 / ランゲルハンス細胞 / 転写調節因子 / 好酸球分化 / 血管内皮細胞 / tie / 造血幹細胞腫瘍 / エピジェネティック治療標的 / マウスモデル / UTX / 多発性骨髄腫 / クロマチンアクセスビリティー / 非ゲノム情報 / クロマチン高次構造 / 運命決定 / クロマチン複製 / 運命制御 / 脂肪髄 / 脂肪分化 / 傍血管間葉系ストローマ細胞 / 骨髄ニッチ / ポリコーム抑制性複合体 / 脂肪化 / ニッチ / 急性Tリンパ芽球性白血病 / 急性リンパ芽球せい白血病 / Bcor / がん抑制遺伝子 / BCOR / Ezh2 / Ezh1 / 骨髄増殖性腫瘍 / 血液 / Kdm2b / Pcgf1 / Mel-18 / Rae-28 / Mph-1 / M33 / thrombopoietin / STAT / 体外増幅 / トロンボポイエチン / Eosinophil / CLEBP / 好酸球 / DNA損傷 / DNA損傷応答 / ストレスシグナル / 幹細胞老化と疾患 / 総括班 / 非蛋白コードRNA / 骨随異形成症候群 / ダイレクトリプログラミング / lineRNA / 白血病 / Arf / Ink4a / bivalent domain / Fus / ヒストン脱メチル化酵素 / 赤芽球分化 / ヒストンアセチルビ酵素 / BRPF2 / BRD1 / TIF1β / Hbo1 / Brpf1 / Brd1 / ヒストンアセチル化酵素複合体 / gene silencing / NuA4 / DNA damage / Ring1b / 傍大動脈生殖腺中腎領域 / 卵黄嚢 / 表面マーカー / 造血発生 / 細胞記憶 / GDNF / PLZF / ニッシェ / ノックイン / PU.1 / 転写因子 / 遺伝子変異 / 好中球分化 / EBPα / 急性骨髄性白血病 / interleakin-5受容体 / アポトーシス / マクロファージ / RON / STK / モノクローナル抗体 / tek … More
Except Principal Investigator
造血幹細胞 / TEK / エピジェネティクス / 自己複製能 / 自己複製 / LFA-1 / TIE / EZH2 / SP細胞 / DNAM-1 / 血液幹細胞 / 血液内科学 / 骨髄線維症 / プロテアソーム阻害剤 / 多発性骨髄腫 / CD226 / Angiopoietin / Hemangioblast / FACS / MSP / RON / STK / 骨髄異形成症候群 / RUNX1 / 肝臓癌 / 癌幹細胞 / 可塑性 / bcrp-1 / 免疫制御 / キラーリンパ球 / 接着分子 / TEK遺伝子 / TIE遺伝子 / 受容体型チロシンキナーゼ / CRISPRgRNAスクリーニング / クローナル造血 / ex vivo増幅 / 体外増幅 / 発癌 / 加齢 / EZH2/1共阻害剤 / BRAF / UTX / EZH2/EZH1阻害剤 / 骨髄腫モデルマウス / EZH2/EZH1共阻害剤 / ヒストンメチル化異常 / がん幹細胞 / ポリコーム / JAK2 / TET2 / ポリコーム複合体 / エピゲノム / 慢性骨髄増殖性腫瘍 / クロマチンリモデリング因子 / TERT / BRM / BRG1 / クロマチンリモデリング / TGFβ / EZH2阻害剤 / EZH2阻害薬 / ヒストンメチル化 / エピジェネティック異常 / 肝癌 / ヒストンメチル化酵素 / 幹細胞 / independency of cytokines / differentiation of Th1 / Th2 cells / Th1 cells / rheumatoid arthritis / autoimmune response / Th 2細胞 / Th 1細胞 / サイトカイン非依存性 / 分化誘導 / Th2細胞 / Th1細胞 / 関節リウマチ / 自己免疫応答 / plasticity / self-renewal / hematopoietic stem cells / ABCG2 / ABC transporter / 肝幹細胞 / Gfi-1B / アダプター分子 / lnk / 血管内皮前駆細胞 / 造血肝細胞 / CD1112 / CD155 / cancer / viral infection / killer lymphocytes / 生体防御 / AGM region / アンギオポエチレン / 血管内皮細胞 / AGM領域 / Reccptor tyrosine kinases / Endothelial cells / Hematopoietic Stem Cells / RON遺伝子 / HTK / 細胞接着 / 低酸素 / ニッチ / 白血病 / 血液腫瘍学 / MDS / 国際情報交換 / 急性骨髄性白血病 / MLL-PTD / 前駆細胞 / T細胞分化 / 転写因子ネットワーク / チェックポイント / 分化停止 / 遺伝子 / 細胞・組織 / 発生・分化 / 免疫学 / B細胞系列 / T細胞系列 / 転写因子 / 系列決定 / DZNep / BMI1 / ポリコーム群遺伝子 / フローサイトメトリー / CD90 / CD133 / Bmil / CD133, CD90 / Bmi1 / p53 / Dmapl / 細胞老化 / Dmap1 / 線維芽細胞 / ホーミング / ニッシェ / 活性型STAT / blastcyst / 対娘細胞解析 / 非対称性分裂 / ポリコーム遺伝子群 / Competitive Repopulation Unit / Repopulation Unit / 精子幹細胞 / Bmi-1 / ポリコーム群タンパク / myeloproliferative disorder / TMTSP / STAT5 / Endomucin / サイトカイン / Lnk / 細胞内抗体 / CCR5 / 遺伝子治療 / ベクター / レンチウイルス / HIV / エイズ / Sl変異 / W変異 / SCF / マスト細胞 / 精細胞 / がん原遺伝子 / c-kit Less
  • Research Projects

    (60 results)
  • Research Products

    (363 results)
  • Co-Researchers

    (71 People)
  •  Pathogenec implication of hematopoietic stem cell aging in age-associated hematological malignanciesPrincipal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2024 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      The University of Tokyo
  •  Development of epigenetic therapy against multiple myeloma using a mouse modelPrincipal Investigator

    • Principal Investigator
      Iwama Atsushi
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      The University of Tokyo
  •  Analysis of stemness, aging and carcinogenesis using hematopoietic stem cell ex vivo amplification system

    • Principal Investigator
      中内 啓光
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      Tokyo Medical and Dental University
      The University of Tokyo
  •  Establishing a new paradigm of pathogenesis of the diseases through the understanding of stem cell agingPrincipal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2019
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Characterization of chromatin replication associated with stem cell fate decisionPrincipal Investigator

    • Principal Investigator
      Iwama Atsushi
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Deciphering of the epigenetic machinery that determines the hallmarks of hematopoietic stem cell agingPrincipal Investigator

    • Principal Investigator
      Iwama Atsishi
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      The University of Tokyo
  •  Pathogenic role of niche aging in the development of age-associated hematological malignanciesPrincipal Investigator

    • Principal Investigator
      Iwama Atsushi
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      The University of Tokyo
  •  Tumor suppressor role of BCOR in hematopoiesisPrincipal Investigator

    • Principal Investigator
      Iwama Atsushi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Epigenetic pathogenesis of multiple myeloma related to drug resistance

    • Principal Investigator
      Naoya Mimura
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Establishing a new paradigm of pathogenesis of the diseases through the understanding of stem cell agingPrincipal Investigator

    • Principal Investigator
      Iwama Atsushi
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
      Chiba University
  •  Pathological role of the dysregulated polycomb functions in hematological malignanciesPrincipal Investigator

    • Principal Investigator
      Iwama Atsushi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Establishing a new paradigm of pathogenesis of the diseases through the understanding of stem cell agingPrincipal Investigator

    • Principal Investigator
      Iwama Atsushi
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
      Chiba University
  •  Epigenetics and stress signals in stem cell agingPrincipal Investigator

    • Principal Investigator
      Iwama Atsushi
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
      Chiba University
  •  Establishing a new paradigm of the pathogenesis of diseases through the understanding of stem cell agingArea Organizer

    • Area Organizer
      岩間 厚志
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
  •  Abberant histone methylation as a therapeutic target in multiple myeloma

    • Principal Investigator
      MIMURA Naoya
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Analysis of the mechanism of myelofibrosis with Smad3 knock out mice

    • Principal Investigator
      TAKEUCHI Masahiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  HSC regulation by TERT-binding proteins, chromatin remodeling factor BRG1/BRM

    • Principal Investigator
      Nitta Eriko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Epigenetic dysregulation in myelodysplastic syndromes in the absence of Ezh2

    • Principal Investigator
      SASHIDA GORO
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University
  •  白血病幹細胞における新規治療標的としての長鎖非蛋白コードRNAの同定と機能解析Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
  •  The regulatory machinery of histone methyltransferases ESET in normal liver and liver cancer

    • Principal Investigator
      Chiba Tetsuhiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  Role of epigenetic dysregulation in the pathogenesis of hematological malignanciesPrincipal Investigator

    • Principal Investigator
      IWAMA Atsushi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  癌幹細胞の特性維持に関わる長鎖非蛋白コードRNAの同定と新規治療標的としての検討Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
  •  Molecular mechanism of MLL mutant-induced MDS

    • Principal Investigator
      SASHIDA Goro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Analysis of the function of LR11 on normal leukocytes and leukemia cells

    • Principal Investigator
      TAKEUCHI Masahiro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Direct reprogramming of hematopoietic cells into hematopoietic stem cellsPrincipal Investigator

    • Principal Investigator
      IWAMA Atsushi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Clarification of molecular mechanisms regulating lineage commitment taking place on the way from multipotent hematopoietic progenitors to unipotent T cell progenitors

    • Principal Investigator
      KAWAMOTO Hiroshi
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
      The Institute of Physical and Chemical Research
  •  Regulation of hematopoietic and leukemic stem cells by the polycomb complexesPrincipal Investigator

    • Principal Investigator
      IWAMA Atsushi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  Investigation of novel target genes regulated by polycomb group genes in hepatocellular carcinoma

    • Principal Investigator
      CHIBA Tetsuhiro
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  ポリコーム複合体を中心としたエピゲノムネットワークの解析Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
  •  自家培養細胞移植の新規分子基盤の確立とその応用Principal Investigator

    • Principal Investigator
      岩間 厚志, 吉田 行貴
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Plastic surgery
    • Research Institution
      Chiba University
  •  Investigation of cancer stem cell system in hepatocellular carcinoma

    • Principal Investigator
      CHIBA Tetsuhiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Chiba University
  •  白血病幹細胞の自己複製の分子基盤の解明Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
  •  生殖系幹細胞の自己複製制御機構の解明Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
  •  ポリコーム遺伝子Bmi-1によるエピジェネティクス制御Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
  •  Epigenetic regulation of hematopoietic stem cell self renewalPrincipal Investigator

    • Principal Investigator
      IWAMA Atsushi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  ポリコーム複合体によるDNAメチル化の維持と幹細胞機能Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
  •  胎児型造血幹細胞の新しい純化法と遺伝子プロファイリングPrincipal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Chiba University
  •  ポリコーム遺伝子Bmi-1による精子幹細胞の未分化性維特機構Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Chiba University
      The University of Tokyo
  •  Regulation of hematopoietic stem cell self-renewal by a polycomb gene product Bmi1Principal Investigator

    • Principal Investigator
      IWAMA Atsushi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Chiba University
      The University of Tokyo
  •  造血幹細胞の可視化とその応用Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  骨髄幹細胞の可塑性とそのメカニズム

    • Principal Investigator
      中内 啓光
    • Project Period (FY)
      2002 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  造血幹細胞をニッシェに導くホーミングレセプターのクローニング

    • Principal Investigator
      中内 啓光
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  Development of a novel molecular therapy for rheumatoid arthritis by regulation of Th1/Th2 differentiation

    • Principal Investigator
      SHIBUYA Kazuko
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      University of Tsukuba
      The Institute of Physical and Chemical Research
  •  Role of STAT5 in regulation of hematopoietic stem cell functionPrincipal Investigator

    • Principal Investigator
      IWAMA Atsushi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  レンチウイルスベクターによるHIV感染症の遺伝子治療

    • Principal Investigator
      中内 啓光
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  C/EBP転写因子ファミリーによる骨髄球分化の制御機構Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  転写調節因子による骨髄球系樹状細胞の分化と機能制御Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
      University of Tsukuba
  •  Plasticity and diversity of hematopoietic stem cells

    • Principal Investigator
      NAKAUCHI Hiromitsu
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Hematology
    • Research Institution
      THE UNIVERSITY OF TOKYO
      University of Tsukuba
  •  転写調節による好酸球分化の制御機構の解析Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  LFA-1/DNAM-1リンパ球接着分子複合体による免疫制御機構の解析

    • Principal Investigator
      SHIBUYA Akira
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  急性骨髄性白血病の病態形成における転写因子C/EBPαの遺伝子変異の生物学的意義Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba
  •  ANALYSIS OF IMMUNE REGULATION BY ADHESION MOLECULE COMPLEX ON KILLER LYMPHOCYTES

    • Principal Investigator
      SHIBUYA Akira
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      UNIVERSITY OF TSUKUBA
  •  Transcriptional regulation of eosinophil developmentPrincipal Investigator

    • Principal Investigator
      IWAMA Atsushi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      UNIVERSITY OF TSUKUBA
  •  受容体型チロシンキナーゼSTK/RONの血液細胞における機能解析Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University
  •  Functional analyzes for common receptor tyrosine kinases of hematopoietic stem cells and vascular endothelial cells

    • Principal Investigator
      SUDA Toshio
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University
  •  c-kitがん原遺伝子の発現と機能

    • Principal Investigator
      西宗 義武
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  全能性幹細胞における受容体型チロシンキナーゼtieの発現Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University
  •  血液幹細胞に特異的に発現されるTIE受容体のリガンドの検索

    • Principal Investigator
      SUDA Toshio
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kumamoto University
  •  造血幹細胞の増殖、分化に関与する受容体型チロシンキナーゼTIEファミリーの解析Principal Investigator

    • Principal Investigator
      岩間 厚志
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University
  •  Cloning of Seel-renewal factor receptors from hemopoietic stem cells

    • Principal Investigator
      SUDA Toshio
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University School of Medicine

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 2004 Other

All Journal Article Presentation Book

  • [Book] 多発性骨髄腫学ー最新の診療と基礎研究ー2016

    • Author(s)
      三村尚也 岩間厚志(分担著者)
    • Publisher
      日本臨牀社
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Book] 日本臨牀 多発性骨髄腫学 2016年7月増刊号2016

    • Author(s)
      三村尚也、岩間厚志
    • Publisher
      日本臨牀社
    • Data Source
      KAKENHI-PROJECT-26860719
  • [Book] Stem Cells and Cancer Stem Cells2013

    • Author(s)
      Wendt G, Nakamura S, and Iwama A.
    • Total Pages
      10
    • Publisher
      Springer.
    • Data Source
      KAKENHI-PROJECT-24249054
  • [Book] 「幹細胞のエピジェネティクス」「再生医療叢書1幹細胞」(山中伸弥、中内啓光編)2012

    • Author(s)
      岩間厚志
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Book] 「造血幹細胞」「みんな2012

    • Author(s)
      岩間厚志
    • Publisher
      医薬ジャーナル社
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Book] 「白血病幹細 胞におけるエピジェネティクス制御」「造血 器腫瘍とエピジェネティクス」(木崎昌弘編)2012

    • Author(s)
      指田吾郎、岩間 厚志
    • Publisher
      医薬ジャーナル
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Book] 白血病幹細胞の維持機構2011

    • Author(s)
      小沼貴晶, 岩間厚志
    • Publisher
      羊土社,東京
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Book] 「造血」疾患モデルマウス表現型解析指南2011

    • Author(s)
      指田吾郎, 岩間厚志
    • Publisher
      中山書店,東京
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Book] 造血幹細胞と再生医療2010

    • Author(s)
      大澤光次郎, 大津真, 岩間厚志
    • Publisher
      羊土社,東京
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Book] 「白血病幹細胞」「造血器腫瘍アトラス」2009

    • Author(s)
      岩間厚志
    • Publisher
      日本医事新報社,東京
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Book] 「造血系癌幹細胞(白血病幹細胞)」「炎症・再生医学辞典」2009

    • Author(s)
      岩間厚志
    • Publisher
      朝倉書店,東京
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Book] 造血幹細胞のエピジェ ネティクス」Annual Review 血液(高久史麿、小澤敬也、坂田洋一、金倉譲、小島勢二編)

    • Author(s)
      岩間厚志
    • Publisher
      中外医学
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms2023

    • Author(s)
      1.Shibamiya A, Miyamoto-Nagai Y, Koide S, Oshima M, Rizq O, Aoyama K, Nakajima-Takagi Y, Kato R, Kayamori K, Isshiki Y, Oshima-Hasegawa N, Muto T, Tsukamoto S, Takeda Y, Koyama-Nasu R, Chiba T, Honda H, Yokote K, Iwama A, Sakaida E, Mimura N.
    • Journal Title

      Cancer Immunol Immunother

      Volume: - Issue: 8 Pages: 2635-2648

    • DOI

      10.1007/s00262-023-03447-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K19497, KAKENHI-PROJECT-22K08495, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-22K16298, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-23K27442
  • [Journal Article] Mesenchymal loss of p53 alters stem cell capacity and models human soft tissue sarcoma traits.2023

    • Author(s)
      Sorimachi Y, Kobayashi H, Shiozawa Y, Koide S, Nakato R, Shimizu Y, Okamura T, Shirahige K, Iwama A, Goda N, Takubo K, Takubo K.
    • Journal Title

      Stem Cell Reports

      Volume: S2213-6711(23) Issue: 5 Pages: 00097-8

    • DOI

      10.1016/j.stemcr.2023.03.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20H05940, KAKENHI-PROJECT-23K06416, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22KJ2948, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H05686, KAKENHI-PROJECT-21H02957
  • [Journal Article] Chemically defined cytokine-free expansion of human haematopoietic stem cells2023

    • Author(s)
      Sakurai Masatoshi、Ishitsuka Kantaro、Ito Ryoji、Wilkinson Adam C.、Kimura Takaharu、Mizutani Eiji、Nishikii Hidekazu、Sudo Kazuhiro、Becker Hans Jiro、Takemoto Hiroshi、Sano Tsubasa、Kataoka Keisuke、Takahashi Satoshi、Nakamura Yukio、Kent David G et al.
    • Journal Title

      Nature

      Volume: 615 Issue: 7950 Pages: 127-133

    • DOI

      10.1038/s41586-023-05739-9

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-21F21108, KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-23K21401, KAKENHI-PROJECT-20H05695
  • [Journal Article] Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis2023

    • Author(s)
      Nakajima-Takagi Yaeko、Oshima Motohiko、Takano Junichiro、Koide Shuhei、Itokawa Naoki、Uemura Shun、Yamashita Masayuki、Andoh Shohei、Aoyama Kazumasa、Isshiki Yusuke、Shinoda Daisuke、Saraya Atsunori、Arai Fumio、Yamaguchi Kiyoshi、Furukawa Yoichi、Koseki Haruhiko、Ikawa Tomokatsu、Iwama Atsushi
    • Journal Title

      eLife

      Volume: 12

    • DOI

      10.7554/elife.83004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K07806, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653
  • [Journal Article] Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs2023

    • Author(s)
      Yokomizo-Nakano T, Hamashima A, Kubota S, Bai J, Sorin S, Sun Y, Kikuchi K, Iimori M, Morii M, Kanai A, Iwama A, Huang G, Kurotaki D, Takizawa H, Matsui H, Sashida G.
    • Journal Title

      Journal of Experimental Medicine (JEM)

      Volume: 220 (7) Issue: 7 Pages: 9999-9999

    • DOI

      10.1084/jem.20220962

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22KJ2522, KAKENHI-PROJECT-21K19512, KAKENHI-PROJECT-22K16304, KAKENHI-PROJECT-21K06870, KAKENHI-PROJECT-21K08419, KAKENHI-PROJECT-21K08421, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-21H02952
  • [Journal Article] UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease2023

    • Author(s)
      Rizq O, Mimura N, Oshima M, Momose S, Takayama N, Koide S, Shibamiya A, Nagai Y, Rizk M, Itokawa N, Nakajima-Takagi Y, Aoyama K, Wang C, Saraya A, Seimiya M, Watanabe M, Yamasaki S, Shibat T, Yamaguchi K, Furukawa Y, Sakaida E, Nakaseko C, Tamaru J, Tai Y-T, Anderson KC, Honda H, and Iwama A.
    • Journal Title

      Leukemia

      Volume: -

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K19497
  • [Journal Article] Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells2022

    • Author(s)
      Itokawa Naoki、Oshima Motohiko、Koide Shuhei、Takayama Naoya、Kuribayashi Wakako、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Yamazaki Satoshi、Yamaguchi Kiyoshi、Furukawa Yoichi、Eto Koji、Iwama Atsushi
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 2691-2691

    • DOI

      10.1038/s41467-022-30440-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-21F21108, KAKENHI-PROJECT-20K07563, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-21H05047
  • [Journal Article] PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment2022

    • Author(s)
      Takano J, Ito S, Dong Y, Sharif J, Nakajima-Takagi Y, Umeyama T, Han YW, Isono K, Kondo T, Iizuka Y, Miyai T, Koseki Y, Ikegaya M, Sakihara M, Nakayama M, Ohara O, Hasegawa Y, Hashimoto K, Arner E, Klose RJ, Iwama A, Koseki H, Ikawa T
    • Journal Title

      Nat Commun.

      Volume: 13 (1) Issue: 1 Pages: 7159-7159

    • DOI

      10.1038/s41467-022-34856-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K06129, KAKENHI-PROJECT-21K16257, KAKENHI-PROJECT-19H05653, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746
  • [Journal Article] Unraveling unique features of plasma cell clones in POEMS syndrome with single-cell analysis.2022

    • Author(s)
      Isshiki Y, Oshima M, Mimura N, Kayamori K, Miyamoto-Nagai Y, Seki M, Nakajima-Takagi Y, Kanamori T, Iwamoto E, Muto T, Tsukamoto S, Takeda Y, Ohwada C, Misawa S, Ikeda JI, Sanada M, Kuwabara S, Suzuki Y, Sakaida E, Nakaseko C, Iwama A.
    • Journal Title

      JCI Insight

      Volume: 7 Issue: 20 Pages: 1-13

    • DOI

      10.1172/jci.insight.151482

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07955, KAKENHI-PROJECT-21K06881, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K08447, KAKENHI-PROJECT-22K08471, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20K08723, KAKENHI-PLANNED-19H05746
  • [Journal Article] A high prevalence of myeloid malignancies in progeria with Werner syndrome is associated with p53 insufficiency2022

    • Author(s)
      Kato Hisaya、Ogawa Seishi, et al.
    • Journal Title

      Experimental Hematology

      Volume: 109 Pages: 11-17

    • DOI

      10.1016/j.exphem.2022.02.005

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-20H00524, KAKENHI-PROJECT-22K15682, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H00528, KAKENHI-PROJECT-20H03572, KAKENHI-PROJECT-20K07810, KAKENHI-PLANNED-19H05746
  • [Journal Article] YAP1/TAZ activity maintains vascular integrity and organismal survival2022

    • Author(s)
      Uemura Shun、Yamashita Masayuki、Aoyama Kazumasa、Yokomizo-Nakano Takako、Oshima Motohiko、Nishio Miki、Masuko Masayoshi、Takizawa Jun、Sone Hirohito、Yamada Yasuhiro、Suzuki Akira、Iwama Atsushi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 619 Pages: 117-123

    • DOI

      10.1016/j.bbrc.2022.06.050

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K08457, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-21H04806, KAKENHI-PLANNED-19H05746
  • [Journal Article] Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis2021

    • Author(s)
      Shinoda Daisuke、Nakajima-Takagi Yaeko、Oshima Motohiko、Koide Shuhei、Aoyama Kazumasa、Saraya Atsunori、Harada Hironori、Rahmutulla Bahityar、Kaneda Atsushi、Yamaguchi Kiyoshi、Furukawa Yoichi、Koseki Haruhiko、Shimoda Kazuya、Tanaka Tomoaki、Sashida Goro、Iwama Atsushi
    • Journal Title

      Leukemia

      Volume: 36 Issue: 2 Pages: 452-463

    • DOI

      10.1038/s41375-021-01402-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K21625, KAKENHI-PROJECT-20K17370, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-19H03708, KAKENHI-PROJECT-20H03713, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-21K19398, KAKENHI-PROJECT-19H04355, KAKENHI-PROJECT-20K07563
  • [Journal Article] Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche2021

    • Author(s)
      Kuribayashi W, Oshima M, Itokawa N, Koide S, Nakajima-Takagi Y, Yamashita M, Yamazaki S, Rahmutulla B, Miura F, Ito T, Kaneda A, Iwama A.
    • Journal Title

      J Exp Med

      Volume: 218 Issue: 3

    • DOI

      10.1084/jem.20192283

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21612, KAKENHI-PROJECT-19KK0216, KAKENHI-PLANNED-19H05746, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-20K17370, KAKENHI-PROJECT-21K08366
  • [Journal Article] UTX maintains functional integrity of murine hematopoietic system by globally regulating aging-associated genes.2021

    • Author(s)
      Sera Y; Nakata Y; Ueda T; Yamasaki N; Koide S; Kobayashi H; Ikeda KI; Kobatake K; Iwasaki M; Oda H; Wolff L; Kanai A; Nagamachi A; Inaba T; Sotomaru Y; Ichinohe T; Koizumi M; Miyakawa Y; Honda ZI; Iwama A; Suda T; Takubo K; Honda H
    • Journal Title

      Blood.

      Volume: 137 Issue: 7 Pages: 908-922

    • DOI

      10.1182/blood.2019001044

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07346, KAKENHI-PROJECT-19K22546, KAKENHI-PROJECT-19K17918, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-18K08357, KAKENHI-PROJECT-18K18196, KAKENHI-PROJECT-19K17847, KAKENHI-PROJECT-19H01056, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-21K08378, KAKENHI-PROJECT-21K08395
  • [Journal Article] DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes2021

    • Author(s)
      Kayamori Kensuke、Nagai Yurie、Zhong Cheng、Kuribayashi Wakako、Oshima Motohiko、Nakajima-Takagi Yaeko、Yamashita Masayuki、Mimura Naoya、Becker Hans Jiro、Izawa Kiyoko、Yamazaki Satoshi、Iwano Satoshi、Ito Ryoji、Lennox William、Sheedy Josephine、Yokote Koutaro、Iwama Atsushi
    • Journal Title

      Blood Advances

      Volume: 5 Issue: 2 Pages: 438-450

    • DOI

      10.1182/bloodadvances.2020001461

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-20K21612, KAKENHI-PLANNED-19H05746, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-20J21190, KAKENHI-PROJECT-20H03178, KAKENHI-PROJECT-21K08366
  • [Journal Article] The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells.2021

    • Author(s)
      Nagai Y, Mimura N, Nakaseko C et al
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 2074-2074

    • DOI

      10.1038/s41598-021-81577-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08338, KAKENHI-PROJECT-19K08807, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-21K19497
  • [Journal Article] PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome2020

    • Author(s)
      Aoyama K, Shinoda D, Suzuki E, Nakajima-Takagi Y, Oshima M, Koide S, Rizq O, Si S, Tara S, Sashida G, Iwama A.
    • Journal Title

      Leukemia

      Volume: 4 Issue: 4 Pages: 1156-1165

    • DOI

      10.1038/s41375-020-01023-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K17370, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-21K08366
  • [Journal Article] Efficacy of the novel tubulin polymerization inhibitor PTC‐028 for myelodysplastic syndrome2020

    • Author(s)
      Zhong Cheng、Kayamori Kensuke、Koide Shuhei、Shinoda Daisuke、Oshima Motohiko、Nakajima‐Takagi Yaeko、Nagai Yurie、Mimura Naoya、Sakaida Emiko、Yamazaki Satoshi、Iwano Satoshi、Miyawaki Atsushi、Ito Ryoji、Tohyama Kaoru、Yamaguchi Kiyoshi、Furukawa Yoichi、Lennox William、Sheedy Josephine、Weetall Marla、Iwama Atsushi
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 12 Pages: 4336-4347

    • DOI

      10.1111/cas.14684

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-20K07563, KAKENHI-PROJECT-20K21612, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707
  • [Journal Article] Plant homeodomain finger protein 6 in the regulation of normal and malignant hematopoiesis.2020

    • Author(s)
      Miyagi S, Iwama A.
    • Journal Title

      Curr Opin Hematol.

      Volume: - Issue: 4 Pages: 248-253

    • DOI

      10.1097/moh.0000000000000588

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-19K08865
  • [Journal Article] Bmi1 counteracts hematopoietic stem cell aging by repressing target genes and enforcing the stem cell gene signature.2020

    • Author(s)
      Nitta E, Itokawa N, Yabata S, Koide S, Hou LB, Oshima M, Aoyama K, Saraya A, Iwama A.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 521 Issue: 3 Pages: 612-619

    • DOI

      10.1016/j.bbrc.2019.10.153

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08348, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-17K09900, KAKENHI-PROJECT-18K19555
  • [Journal Article] The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.2019

    • Author(s)
      Miyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, and Iwama A.
    • Journal Title

      Blood

      Volume: - Issue: 23 Pages: 2495-2506

    • DOI

      10.1182/blood.2019000468

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16K09840, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-19K08865, KAKENHI-WRAPUP-19H05442, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-18K19555
  • [Journal Article] Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma.2019

    • Author(s)
      Rizk M, Rizq O, Oshima M, Nakajima-Takagi Y, Koide S, Saraya A, Isshiki Y, Chiba T, Yamazaki S, Ma A, Jin J, Iwama A, Mimura N.
    • Journal Title

      Cancer Sci

      Volume: 110 Issue: 12 Pages: 3695-3707

    • DOI

      10.1111/cas.14207

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-19K08807, KAKENHI-PUBLICLY-18H05095, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-17H05086, KAKENHI-PROJECT-18K19555
  • [Journal Article] Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation.2019

    • Author(s)
      Kanatsu-Shinohara, M., Yamamoto, T., Toh, H., Kazuki, Y., Kazuki, K., Imoto, J., Ikeo, K., Oshima, M., Shirahige, K., Iwama, A., Nabeshima, Y., Sasaki, H. and Shinohara, T.
    • Journal Title

      PNAS

      Volume: 116 Issue: 33 Pages: 16404-16409

    • DOI

      10.1073/pnas.1904980116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22512, KAKENHI-PUBLICLY-18H04882, KAKENHI-PUBLICLY-19H04906, KAKENHI-WRAPUP-19H05442, KAKENHI-ORGANIZER-19H05749, KAKENHI-PROJECT-18H05281, KAKENHI-PROJECT-18H02935
  • [Journal Article] KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesis.2019

    • Author(s)
      Isshiki Y, Nakajima-Takagi Y, Oshima M, Aoyama K, Rizk M, Kurosawa S, Saraya A, Kondo T, Sakaida E, Nakaseko C, Yokote K, Koseki H, Iwama A.
    • Journal Title

      Blood Adv

      Volume: 3 Issue: 17 Pages: 2537-2549

    • DOI

      10.1182/bloodadvances.2018028522

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08348, KAKENHI-WRAPUP-19H05442, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-18K19555
  • [Journal Article] PLZF limits enhancer activity during hematopoietic progenitor aging.2019

    • Author(s)
      Poplineau M, Vernerey J, Platet N, Nguyen L, Herault L, Esposito M, Saurin AJ, Guilouf C, Iwama A, Duprez E.
    • Journal Title

      Cell Stem Cell

      Volume: 47 Issue: 9 Pages: 4509-4520

    • DOI

      10.1093/nar/gkz174

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-WRAPUP-19H05442
  • [Journal Article] Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche2019

    • Author(s)
      Kato Yuko、Hou Li-Bo、Miyagi Satoru、Nitta Eriko、Aoyama Kazumasa、Shinoda Daisuke、Yamazaki Satoshi、Kuribayashi Wakako、Isshiki Yusuke、Koide Shuhei、Si Sha、Saraya Atsunori、Matsuzaki Yumi、van Lohuizen Maarten、Iwama Atsushi
    • Journal Title

      Experimental Hematology

      Volume: 76 Pages: 24-37

    • DOI

      10.1016/j.exphem.2019.07.006

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08865, KAKENHI-PUBLICLY-18H05095, KAKENHI-WRAPUP-19H05442, KAKENHI-PROJECT-17H05086, KAKENHI-PROJECT-17K09900, KAKENHI-PROJECT-18K19555
  • [Journal Article] Bcor insufficiency promotes initiation and progression of myelodysplastic syndrome.2018

    • Author(s)
      Tara S, Isshiki Y, Nakajima-Takagi Y, Oshima M, Aoyama K, Tanaka T, Shinoda D, Koide S, Saraya A, Miyagi S, Manabe I, Matsui H, Koseki H, Bardwell VJ, Iwama A.
    • Journal Title

      Blood

      Volume: 132(23) Issue: 23 Pages: 2470-2483

    • DOI

      10.1182/blood-2018-01-827964

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08348, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16K09840, KAKENHI-INTERNATIONAL-15K21751
  • [Journal Article] Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.2018

    • Author(s)
      Si S, Nakajima-Takagi Y, Iga, T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, and Iwama A.
    • Journal Title

      Exp Hematol

      Volume: 63 Pages: 41-51

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Journal Article] Ezh2 loss propagates hypermethylation at T cell differentiation?regulating genes to promote leukemic transformation2018

    • Author(s)
      Wang Changshan、Oshima Motohiko、Sato Daisuke、Matsui Hirotaka、Kubota Sho、Aoyama Kazumasa、Nakajima-Takagi Yaeko、Koide Shuhei、Matsubayashi Jun、Mochizuki-Kashio Makiko、Nakano-Yokomizo Takako、Bai Jie、Nagao Toshitaka、Kanai Akinori、Iwama Atsushi、Sashida Goro
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128 Issue: 9 Pages: 3872-3886

    • DOI

      10.1172/jci94645

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08705, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-18K18196, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-18K16078, KAKENHI-PROJECT-16H06276
  • [Journal Article] Ezh1 Targets Bivalent Genes to Maintain Self-Renewing Stem Cells in Ezh2-Insufficient Myelodysplastic Syndrome.2018

    • Author(s)
      Aoyama K, Oshima M, Koide S, Suzuki E, Mochizuki-Kashio M, Kato Y, Tara S, Shinoda D, Hiura N, Nakajima-Takagi Y, Sashida G, Iwama A.
    • Journal Title

      iScience

      Volume: 9 Pages: 161-174

    • DOI

      10.1016/j.isci.2018.10.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08348, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-16H06276
  • [Journal Article] Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia.2017

    • Author(s)
      Seki M, Kimura S, Isobe T, Yoshida K, (13 authors), Masuda K, Kawamoto H, Ohki K, Kato M, Arakawa Y, Koh K, Hanada R, Moritake H, Akiyama M, Kobayashi R, Deguchi T, Hashii Y, Imamura T, Sato A, Kiyokawa N, Oka A, Hayashi Y, Takagi M, Manabe A, Ohara A, Horibe K, Sanada M, Iwama A, Mano H, Miyano S, Ogawa S, Takita J
    • Journal Title

      Nature Genetics

      Volume: 49 Issue: 8 Pages: 1274-1281

    • DOI

      10.1038/ng.3900

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09870, KAKENHI-PROJECT-17K10130, KAKENHI-PROJECT-17K10136, KAKENHI-PLANNED-15H05909, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-17H04234, KAKENHI-PROJECT-15K12139, KAKENHI-PROJECT-16K15498, KAKENHI-PROJECT-16K19574, KAKENHI-PROJECT-17K16242, KAKENHI-PROJECT-15H05707, KAKENHI-PROJECT-15H05325
  • [Journal Article] Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.2017

    • Author(s)
      Yong KJ, et al., Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, Levantini E.
    • Journal Title

      Sci Transl Med

      Volume: 8 Issue: 350

    • DOI

      10.1126/scitranslmed.aad6066

    • Data Source
      KAKENHI-INTERNATIONAL-15K21751
  • [Journal Article] Dual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition.2017

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama
    • Journal Title

      Clinical Cancer Research

      Volume: 23(16) Issue: 16 Pages: 4817-4830

    • DOI

      10.1158/1078-0432.ccr-16-2735

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09839, KAKENHI-INTERNATIONAL-15K21751, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
  • [Journal Article] Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies2017

    • Author(s)
      Sashida G, Iwama A
    • Journal Title

      Int J Hematol

      Volume: 105 Issue: 1 Pages: 23-30

    • DOI

      10.1007/s12185-016-2124-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-16KT0113
  • [Journal Article] Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies2017

    • Author(s)
      Tanaka Tomoyuki、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Tara Shiro、Oshima Motohiko、Saraya Atsunori、Koide Shuhei、Si Sha、Manabe Ichiro、Sanada Masashi、Nakayama Manabu、Masuko Masayoshi、Sone Hirohito、Koseki Haruhiko、Iwama Atsushi
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 214 Issue: 10 Pages: 2901-2913

    • DOI

      10.1084/jem.20170167

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09868, KAKENHI-PROJECT-17K10136, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16K15498, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
  • [Journal Article] Polycomb repressive complexes in hematological malignancies.2017

    • Author(s)
      Iwama A
    • Journal Title

      Blood

      Volume: 130 Issue: 1 Pages: 23-29

    • DOI

      10.1182/blood-2017-02-739490

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16K15498
  • [Journal Article] Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of non-hematopoietic genes.2016

    • Author(s)
      Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y,Iwama A.
    • Journal Title

      Blood

      Volume: 128(5) Issue: 5 Pages: 638-649

    • DOI

      10.1182/blood-2016-01-694810

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01513, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-15J04258, KAKENHI-PROJECT-26293228, KAKENHI-PROJECT-15K09478, KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-16K09840, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
  • [Journal Article] Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells.2016

    • Author(s)
      Oshima M, Hasegawa N, Mochizuki-Kashio M, Muto T, Miyagi S, Koide S, Yabata S, Wendt G, Saraya A, Wang C, Shimoda K, Suzuki Y, Iwama A.
    • Journal Title

      Exp Hematol

      Volume: 44 Pages: 282-296

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Journal Article] The loss of Ezh2 cooperates with an active JAK2 mutant in the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.2016

    • Author(s)
      Sashida G, Wang S, Tomioka T, Oshima M, Kazumasa Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A.
    • Journal Title

      J Experimenta l Medicine

      Volume: 213 Issue: 8 Pages: 1459-1477

    • DOI

      10.1084/jem.20151121

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-15H03137, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-15K09460, KAKENHI-PROJECT-16K09831, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
  • [Journal Article] Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology2016

    • Author(s)
      Chiba T, Iwama A, Yokosuka O
    • Journal Title

      Hepatol Res

      Volume: 46 Issue: 1 Pages: 50-57

    • DOI

      10.1111/hepr.12548

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460977
  • [Journal Article] Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells.2016

    • Author(s)
      Oshima M, Hasegawa N, Mochizuki-Kashio M, Muto T, Miyagi S, Koide S, Yabata S, Wendt G, Saraya A, Wang C, Shimoda K, Suzuki Y, Iwama A
    • Journal Title

      Exp Hematol

      Volume: 44 Pages: 282-296

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Journal Article] Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome.2016

    • Author(s)
      Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A.
    • Journal Title

      Leukemia

      Volume: in press Issue: 4 Pages: 861-871

    • DOI

      10.1038/leu.2016.268

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01513, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H05412, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-16K20959, KAKENHI-PROJECT-17K16530, KAKENHI-PUBLICLY-17H05649, KAKENHI-PROJECT-15K09478
  • [Journal Article] Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator.2015

    • Author(s)
      Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Taniguchi Y, Hidaka T, Kubuki Y, Shimoda H, Marutsuka K, Sashida G, Aoyama K, Yoshimitsu M, Harada T, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, Shimoda K.
    • Journal Title

      Blood

      Volume: 125 Issue: 2 Pages: 304-315

    • DOI

      10.1182/blood-2014-04-555508

    • NAID

      40020613861

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591401, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-15K09479, KAKENHI-PROJECT-15K09507, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26461408, KAKENHI-PROJECT-26860738
  • [Journal Article] Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.2015

    • Author(s)
      Wang C, Oshima M, Sashida G, Tomioka T, Hasegawa N, Mochizuki-Kashio M, Nakajima-Takagi Y, Kusunoki Y, Kyoizumi S, Imai K, Nakachi K, Iwama A.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: e0132041-e0132041

    • DOI

      10.1371/journal.pone.0132041

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-15K19544, KAKENHI-PROJECT-14J40024, KAKENHI-PROJECT-14J40042
  • [Journal Article] Gene expression profiling of loss of TET2 and/or JAK2V617F mutant hematopoietic stem cells from mouse models of myeloproliferative neoplasms.2015

    • Author(s)
      Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Hidaka T, Kubuki Y, Sashida G, Aoyama K, Yoshimitsu M, Abe H, Miike T, Iwakiri H, Tahara Y, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, Shimoda K
    • Journal Title

      Genom Data.

      Volume: 4 Pages: 102-108

    • DOI

      10.1016/j.gdata.2015.04.002

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09479, KAKENHI-PROJECT-15K09480, KAKENHI-PROJECT-15K09507, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26461408, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-26860738
  • [Journal Article] Myelodysplastic syndrome with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice.2015

    • Author(s)
      Muto T, Sashida G, Hasegawa N, Nakaseko C, Yokote K, Shimoda K, Iwama A.
    • Journal Title

      Leuk Lymphoma.

      Volume: 56 Issue: 2 Pages: 520-523

    • DOI

      10.3109/10428194.2014.924120

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591401, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
  • [Journal Article] Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner.2015

    • Author(s)
      Mochizuki-Kashio M, Aoyama K, Sashida G, Oshima M, Tomioka T, Muto T, Wang C, and Iwama A.
    • Journal Title

      Blood

      Volume: 126 Pages: 1172-1183

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-ORGANIZER-26115001
  • [Journal Article] Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner.2015

    • Author(s)
      Mochizuki-Kashio M, Aoyama K, Sashida G, Oshima M, Tomioka T, Muto T, Wang C, and Iwama A.
    • Journal Title

      Blood

      Volume: 126 Pages: 1172-1183

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Journal Article] Non-lethal ionizing radiation promotes aging-like phenotypic changes of human hematopoietic stem and progenitor cells in humanized mice.2015

    • Author(s)
      Wang C, Oshima M, Gashida G, Tomioka T, Hasegawa N, Mochizuki-Kashio M, Nakajima-Takagi Y, Kusunoki Y, Kyoizumi S, Imai K, Nakachi K, and Iwama A.
    • Journal Title

      Plos One

      Volume: 10(7)

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Journal Article] Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma.2015

    • Author(s)
      Chiba T, Saito T, Yuki K, Zen Y, Koide S, Kanogawa N, Motoyama T, Ogasawara S, Suzuki E, Ooka Y, Tawada A, Otsuka M, Miyazaki M, Iwama A, Yokosuka O.
    • Journal Title

      Int J Cancer

      Volume: 136 Issue: 2 Pages: 289-298

    • DOI

      10.1002/ijc.28985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460977
  • [Journal Article] Biological features and biomarkers in hepatocellular carcinoma2015

    • Author(s)
      Chiba T, Suzuki E, Saito T, Ogasawara S, Ooka Y, Tawada A, Iwama A, Yokosuka O
    • Journal Title

      World J Hepatol

      Volume: 7 Issue: 16 Pages: 2020-2028

    • DOI

      10.4254/wjh.v7.i16.2020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460977
  • [Journal Article] がん幹細胞化のメカニズム2015

    • Author(s)
      仁田英里子、岩間厚志
    • Journal Title

      日本臨床

      Volume: 73 Pages: 733-738

    • Data Source
      KAKENHI-PROJECT-26461411
  • [Journal Article] Non-lethal ionizing radiation promotes aging-like phenotypic changes of human hematopoietic stem and progenitor cells in humanized mice.2015

    • Author(s)
      Wang C, Oshima M, Gashida G, Tomioka T, Hasegawa N, Mochizuki-Kashio M, Nakajima-Takagi Y, Kusunoki Y, Kyoizumi S, Imai K, Nakachi K, and Iwama A.
    • Journal Title

      Plos One

      Volume: 10(7)

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Journal Article] Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner.2015

    • Author(s)
      Mochizuki-Kashio M, Aoyama K, Sashida G, Oshima M, Tomioka T, Muto T, Wang C, Iwama A.
    • Journal Title

      Blood

      Volume: 126 Issue: 10 Pages: 1172-83

    • DOI

      10.1182/blood-2015-03-634428

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-14J40024
  • [Journal Article] Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner.2015

    • Author(s)
      Mochizuki-Kashio M, Aoyama K, Sashida G, Oshima M, Tomioka T, Muto T, Wang C, and Iwama A.
    • Journal Title

      Blood

      Volume: 126 Pages: 1172-1183

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Journal Article] Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukemic transformation.2014

    • Author(s)
      Sashida, G., Harada, H., Matsui, H., Oshima, M., Yui, M., Harada, Y., Tanaka, S., Mochizuki-Kashio, M., Wang, C., Saraya, A., Muto, T., Hayasi, Y., Suzuki, K., Nakajima, H., Inaba, T., Koseki, H., Huang, G., Kitamura, T. and Iwama, A.
    • Journal Title

      Nat. Commun.

      Volume: 5 Issue: 1 Pages: 5177-5177

    • DOI

      10.1038/ncomms5177

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-24249039, KAKENHI-PROJECT-24249054, KAKENHI-PROJECT-24591397, KAKENHI-PROJECT-24591398, KAKENHI-PUBLICLY-25118716, KAKENHI-PUBLICLY-25130702, KAKENHI-PROJECT-25461422, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26257501, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26461460
  • [Journal Article] Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners2014

    • Author(s)
      Chiba T, Suzuki E, Yuki K, Zen Y, Oshima M, Miyagi S, Saraya A, Koide S, Motoyama T, Ogasawara S, Ooka Y, Tawada A, Nakatsura T, Hayashi T, Yamashita T, Kaneko S, Miyazaki M, Iwama A, Yokosuka O
    • Journal Title

      PLoS One

      Volume: 9(1) Issue: 1 Pages: e84807-e84807

    • DOI

      10.1371/journal.pone.0084807

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23689039, KAKENHI-PUBLICLY-25130702, KAKENHI-PROJECT-25460977
  • [Journal Article] The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells.2014

    • Author(s)
      Miyagi S, Koide S, Saraya A, Wendt GR, Oshima M, Konuma T, Yamazaki S, Mochizuki-Kashio M, Nakajima-Takagi Y, Wang C, Chiba T, Kitabayashi I, Nakauchi H, Iwama A.
    • Journal Title

      Stem Cell Reports.

      Volume: 2 Issue: 2 Pages: 145-52

    • DOI

      10.1016/j.stemcr.2013.12.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-23689039, KAKENHI-PROJECT-24249054, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-25893049, KAKENHI-PROJECT-221S0002
  • [Journal Article] Epigenetics of hematopoietic stem cell aging and disease.2014

    • Author(s)
      Oshima M and Iwama A
    • Journal Title

      International Journal of Hematology

      Volume: 100 Issue: 4 Pages: 326-334

    • DOI

      10.1007/s12185-014-1647-2

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Journal Article] MDS with extramedullary erythroid hyperplasia induced by loss of Tet2 in mice.2014

    • Author(s)
      Muto T, Sashida G, Hasegawa N, Nakaseko C, Yokote K, Shimoda K and Iwama A.
    • Journal Title

      Leukemia and Lymphoma

      Volume: 17 Issue: 21 Pages: 1-4

    • DOI

      10.1182/blood-2013-12-544544

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249054, KAKENHI-PUBLICLY-25130702, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26461396
  • [Journal Article] Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.2014

    • Author(s)
      Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, Yamaguchi N, Koseki H, Taniuchi I, Iwama A.
    • Journal Title

      Nature Communications

      Volume: 18 Issue: 1 Pages: 5872-5882

    • DOI

      10.1038/ncomms6872

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-14J40042, KAKENHI-PROJECT-24249054, KAKENHI-PROJECT-25460599, KAKENHI-PROJECT-25860351, KAKENHI-PUBLICLY-26114720, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26293109, KAKENHI-PROJECT-26460569, KAKENHI-PROJECT-26461396
  • [Journal Article] Metformin, a Diabetes Drug, Eliminates Tumor-Initiating Hepatocellular Carcinoma Cells.2013

    • Author(s)
      Saito, T., Chiba, T., Yuki, K., Zen, Y., Oshima, M., Koide, S., Motoyama, T., Ogasawara, S., Suzuki, E., Ooka, Y., Tawada, A., Tada, M., Kanai, F., Takiguchi, Y., Iwama, A. and Yokosuka, O.
    • Journal Title

      PloS one

      Volume: 8 Issue: 7 Pages: e70010-e70010

    • DOI

      10.1371/journal.pone.0070010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591136, KAKENHI-PROJECT-23689039, KAKENHI-PROJECT-25460977
  • [Journal Article] Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders.2013

    • Author(s)
      Muto T, Sashida G, Oshima M, Wendt GR, Mochizuki-Kashio M, Nagata Y, Sanada M, Miyagi S, Saraya A, Kamio A, Nagae G, Nakaseko C, Yokote K, Shimoda K, Koseki H, Suzuki Y, Sugano S, Aburatani H, Ogawa S, Iwama A.
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 210(12) Issue: 12 Pages: 2627-39

    • DOI

      10.1084/jem.20131144

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J04875, KAKENHI-PLANNED-22134006, KAKENHI-PROJECT-23249052, KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-23591397, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24249054, KAKENHI-PROJECT-24390242, KAKENHI-PROJECT-24659346, KAKENHI-PROJECT-24659458, KAKENHI-PUBLICLY-25130702, KAKENHI-PROJECT-25670446, KAKENHI-PROJECT-25860521
  • [Journal Article] RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.2013

    • Author(s)
      Harada Y, Inoue D, Ding Y, Imagawa J, Doki N, Matsui H, Yahata T, Matsushita H, Ando K, Sashida G, Iwama A, Kitamura T, and Harada H.
    • Journal Title

      Blood

      Volume: 121 Pages: 3434-3446

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] Role of SOX17 in hematopoietic development from human embryonic stem cells.2013

    • Author(s)
      Nakajima-Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, Endo TA, Takayama N, Eto K, Toyoda T, Koseki H, Nakauchi H, and Iwama A.
    • Journal Title

      Blood

      Volume: 121 Pages: 447-458

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] 「幹細胞老化とエピジェ ネティクス」アンチ・エイジング医学2013

    • Author(s)
      岩間 厚志
    • Journal Title

      日本抗加齢医学会雑誌

      Volume: 9(1)

    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] Ezh2 augments leukemogenecity by reinforcing differentiation blockage in acute myeloid leukemia.2012

    • Author(s)
      Tanaka S, Miyagi S, Sashida G, Chiba T, Yuan J, Mochizuki-Kashio M, Suzuki Y, Sugano S, Nakaseko C, Yokote K, Koseki H, and Iwama A.
    • Journal Title

      Blood

      Volume: 120 Pages: 1107-1117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] New approaches to expand hematopoietic stem and progenitor cells.2012

    • Author(s)
      Nishino T, Osawa M, and Iwama A.
    • Journal Title

      Expert Opin Biol Ther

      Volume: 12 Pages: 743-756

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] 「癌幹細胞とエピゲノム制御異常」2012

    • Author(s)
      指田吾郎、千葉哲博、岩間厚志
    • Journal Title

      細胞工学

      Volume: 31 Pages: 24-31

    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.2012

    • Author(s)
      Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H, and Iwama A.
    • Journal Title

      J Exp Med

      Volume: 209 Pages: 445-454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] TET2 is essential for survival and hematopoietic stem cellhomeostasis.2012

    • Author(s)
      Shide K, Kameda T, Shimoda H, Yamaji T, Abe H, Kamiunten A, Sekine M, Hidaka T, Katayose K, Kubuki Y, Yamamoto S, Miike T, Iwakiri H, Hasuike S, Nagata K, Iwama A, Matsuda T, Kitanaka A and Shimoda K.
    • Journal Title

      Leukemia

      Volume: 26 Pages: 2216-2223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.2012

    • Author(s)
      Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H, and Iwama A.
    • Journal Title

      PLoS ONE

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes2012

    • Author(s)
      Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H, Iwama A
    • Journal Title

      J Exp Med

      Volume: 209 Pages: 445-454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Epigenetic regulation of hematopoiesis.2012

    • Author(s)
      Sashida G, Iwama A.
    • Journal Title

      Int J Hematol.

      Volume: 96 Issue: 4 Pages: 405-12

    • DOI

      10.1007/s12185-012-1183-x

    • NAID

      10031126731

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591367
  • [Journal Article] Epigenetic regulation of hematopoiesis.2012

    • Author(s)
      Sashida G and Iwama A.
    • Journal Title

      Int J Hematol

      Volume: 96 Pages: 405-412

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias.2012

    • Author(s)
      Sakai S, Nakaseko C, Takeuchi M, Ohwada C, Shimizu N, Tsukamoto S, Kawaguchi T, Jiang M, Sato Y, Ebinuma H, Yokote K, Iwama A, Fukamachi I, Schneider WJ, Saito Y, and Bujo H.
    • Journal Title

      Clinica Chemica Acta

      Volume: 413 Pages: 1542-1548

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] Epigenetics of hematopoiesis and hematological malignancies.2012

    • Author(s)
      Iwama A.
    • Journal Title

      Int J Hematol

      Volume: 96 Pages: 403-404

    • Data Source
      KAKENHI-PROJECT-23659483
  • [Journal Article] Non-myelinating Schwann cells in the mouse bone marrow niche maintain haematopoietic stem cell hibernation through TGF-β signaling2011

    • Author(s)
      Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H
    • Journal Title

      Cell

      Volume: 147 Pages: 1146-1158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis2011

    • Author(s)
      Mishima Y, Miyagi S, Saraya A, Negishi M, Endoh M, Endo TA, Toyoda T, Shinga J, Katsumoto T, Chiba T, Yamaguchi N, Kitabayashi I, Koseki H, Iwama A
    • Journal Title

      Blood

      Volume: 118 Pages: 2443-2453

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Direct activation of STAT5 by ETV6-Lyn fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis2011

    • Author(s)
      Takeda Y, Nakaseko C, Tanaka H, Takeuchi M, Yui M, Saraya A, Miyagi S, Wang C, Tanaka S, Ohwada C, Sakaida E, Yamaguchi N, Yokote K, Hennighausen L, Iwama A
    • Journal Title

      Br J Haematol

      Volume: 153 Pages: 589-598

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Dependency on the polycomb protein Ezh2 distinguishes fetal from adult hematopoietic stem cells2011

    • Author(s)
      Mochizuki-Kashio M, Mishima Y, Miyagi S, Negishi M, Saraya A, Konuma T, Shinga J, Koseki H, Iwama A
    • Journal Title

      Blood

      Volume: 118 Pages: 6553-6561

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells2011

    • Author(s)
      Guo Y, Miyazaki M, Itoi M, Satoh R, Iwama A, Amagai T, Kawamoto H, Kanno M
    • Journal Title

      Eur J Immunol

      Volume: 41 Issue: 4 Pages: 1098-1107

    • DOI

      10.1002/eji.201040794

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390297, KAKENHI-PLANNED-22118004, KAKENHI-PROJECT-23616003
  • [Journal Article] Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells2011

    • Author(s)
      Guo Y, Miyazaki M, Itoi M, Satoh R, Iwama A, Amagai T, Kawamoto H, Kanno M
    • Journal Title

      Eur J Immunol

      Volume: 41 Pages: 1098-1107

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells2011

    • Author(s)
      Konuma T, Nakamura S, Miyagi S, Negishi M, Chiba T, Oguro H, Yuan J, Mochizuki-Kashio M, Ichikawa H, Miyoshi H, Vidal M Iwama A
    • Journal Title

      Exp Hematol

      Volume: 39 Pages: 697-709

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells2011

    • Author(s)
      Yuan J, Takeuchi M, Negishi M, Oguro H, Ichikawa H, Iwama A
    • Journal Title

      Leukemia

      Volume: 25 Pages: 1335-1343

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells2010

    • Author(s)
      Sugawara T, Oguro H, Negishi M, Morita Y, Ichikawa H, Iseki T, Yokosuka O, Nakauchi H, Iwama A
    • Journal Title

      Exp Hematol

      Volume: 38 Pages: 696-706

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Depletion of Dnmt1-associated protein 1 triggers DNA damage and compromises the proliferative capacity of hematopoietic stem cells2010

    • Author(s)
      Koizumi T, Negishi M, Nakamura S, Oguro H, Satoh K, Ichinose M, Iwama A
    • Journal Title

      Int J Hematol

      Volume: 91 Pages: 611-611

    • NAID

      10026401960

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] The polycomb-group gene Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and independent manners2010

    • Author(s)
      Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A
    • Journal Title

      Hepatology

      Volume: 52 Pages: 1111-1123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] The polycomb-group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells2010

    • Author(s)
      Aoki R, Chiba T, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A
    • Journal Title

      J Hepatology

      Volume: 52 Pages: 854-863

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/Arf locus through polycomb repressive complex 12010

    • Author(s)
      Negishi M, Saraya A, Mochizuki S, Helin K, Koseki H, Iwama A
    • Journal Title

      PLoS ONE

      Volume: 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Role of polycomb group proteins in hematopoietic stem cells2010

    • Author(s)
      Konuma T, Oguro H, Iwama A
    • Journal Title

      (Review) Dev Growth Differ

      Volume: 52 Pages: 505-516

    • NAID

      10027565475

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Poised lineage specification in multipotent hematopoietic stem and progenitor cells by the polycomb protein Bmi12010

    • Author(s)
      Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, Iwama A
    • Journal Title

      Cell Stem Cell

      Volume: 6 Pages: 279-286

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Bmil promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.2010

    • Author(s)
      Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.
    • Journal Title

      Hepatology 52

      Pages: 1111-1123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Journal Article] Poised lineage specification in multipotent hematopoietic progenitor cells by the polycomb protein Bmi1.2010

    • Author(s)
      Oguro H, Y Jin, H Ichikawa, T Ikawa, S Yamazaki, H Kawamoto, H Nakauchi, A Iwama
    • Journal Title

      Cell Stem Cell

      Volume: 5 Pages: 279-286

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22118004
  • [Journal Article] Identification of a novel TEL-Lyn fusion gene in primary myelofibrosis2010

    • Author(s)
      Tanaka H, Takeuchi M, Takeda Y, Sakai S, Oda K, Abe D, Ohwada C, Ozawa S, Sakaida E, Shimizu N, Saito Y, Miyagi S, Iwama A, Nakaseko C
    • Journal Title

      Leukemia

      Volume: 24 Pages: 297-297

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Array-based genomic resequencing of human leukemia2010

    • Author(s)
      Yamashita Y, Yuan J, Suetake I, Suzuki H, Ishikawa Y, Choi YL, Ueno T, Soda M, Hamada T, Haruta H, Takada S, Miyazaki Y, Kiyoi H, Ito E, Naoe T, Tomonaga M, Toyota M, Tajima S, Iwama A, Mano H
    • Journal Title

      Oncogene

      Volume: 24 Pages: 3723-3731

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.2010

    • Author(s)
      Chiba T, Aoki R, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A.
    • Journal Title

      J Hepatol 52

      Pages: 854-863

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Journal Article] Cancer stem cells in hepatocellular carcinoma : Recent progress and perspective.2009

    • Author(s)
      Chiba T, Kamiya A, Yokosuka O, Iwama A.
    • Journal Title

      Cancer Lett, 286

      Pages: 145-153

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Journal Article] 幹細胞のエピジェネティクス2009

    • Author(s)
      岩間厚志
    • Journal Title

      ゲノム医学 9

      Pages: 171-175

    • Data Source
      KAKENHI-PROJECT-20052009
  • [Journal Article] Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma2009

    • Author(s)
      Yonemitsu Y, Imazeki F, Chiba T, Fukai K, Nagai Y, Miyagi S, Arai M, Aoki R, Miyazaki M, Nakatani Y, Iwama A, Yokosuka O
    • Journal Title

      Hum Pathology

      Volume: 40 Pages: 1304-1311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Cancer stem cells in hepatocellular carcinoma : recent progress and perspective2009

    • Author(s)
      Chiba T, Kamiya A, Yokosuka O, Iwama A
    • Journal Title

      Cancer letters

      Volume: 286 Pages: 145-153

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] DMAP1 is essential for the recruitment of Pcna to repair foci2009

    • Author(s)
      Negishi M, Chiba T, Saraya A, Miyagi S, Iwama A
    • Journal Title

      Genes Cells

      Volume: 14 Pages: 1347-1357

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Dmapl plays an essential role in the maintenance of genome integrity through the DNA repair process.2009

    • Author(s)
      Negishi M, Chiba T, Saraya A, Miyagi S, Iwama A.
    • Journal Title

      Gene Cells, 14

      Pages: 1347-1357

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Journal Article] 幹細胞のエピジェネティクス2009

    • Author(s)
      岩間厚志
    • Journal Title

      ゲノム医学 9

      Pages: 171-175

    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Plk1 regulates liver tumor cell death by phosphorylation of TAp632009

    • Author(s)
      Komatsu S, Takenobu H, Ozaki T, Ando K, Koida N, Suenaga Y, Ichikawa T, Hishiki T, Chiba T, Iwama A, Yoshida H, Ohnuma N, Nakagawara A Kamijo T
    • Journal Title

      Oncogene

      Volume: 28 Pages: 3631-3641

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.2008

    • Author(s)
      Chiba T, Miyagi S, Saraya A, Ryutaro Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H,Iwama A.
    • Journal Title

      Cancer Res 68

      Pages: 7742-7749

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Journal Article] Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.2007

    • Author(s)
      Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi M, Nakano M, Nakauchi H, Iwama A, Taniguchi H.
    • Journal Title

      Gastroenterology 133

      Pages: 937-950

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Journal Article] Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes (Review).2005

    • Author(s)
      Iwama A.
    • Journal Title

      Int.J.Hematol. 81

      Pages: 294-300

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] 幹細胞の自己複製メカニズム2005

    • Author(s)
      岩間厚志
    • Journal Title

      最新医学 60

      Pages: 1740-1746

    • Data Source
      KAKENHI-PROJECT-17054012
  • [Journal Article] 造血幹細胞の自己複製制御機構2005

    • Author(s)
      岩間厚志
    • Journal Title

      炎症と免疫 13

      Pages: 72-79

    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] 幹細胞の自己複製メカニズム2005

    • Author(s)
      岩間厚志
    • Journal Title

      最新医学 60

      Pages: 1740-1746

    • Data Source
      KAKENHI-PROJECT-16045202
  • [Journal Article] ポリコーム遺伝子Bmi-1による造血幹細胞制御2005

    • Author(s)
      岩間厚志
    • Journal Title

      医学のあゆみ別冊「血液疾患ver.3」

      Pages: 55-58

    • Data Source
      KAKENHI-PROJECT-16045202
  • [Journal Article] ポリコーム遺伝子Bmi-1と幹細胞制御2005

    • Author(s)
      岩間厚志
    • Journal Title

      Molecular Medicine臨時増刊号「免疫2006」 42

      Pages: 23-27

    • Data Source
      KAKENHI-PROJECT-17054012
  • [Journal Article] Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes (Review).2005

    • Author(s)
      Iwama A
    • Journal Title

      Int.J.Hematol. 81

      Pages: 294-300

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] ポリコーム遺伝子Bmi-1による造血幹細胞制御2005

    • Author(s)
      岩間厚志
    • Journal Title

      医学のあゆみ別冊「血液疾患ver.3」

      Pages: 55-58

    • Data Source
      KAKENHI-PROJECT-17054012
  • [Journal Article] 造血幹細胞の自己複製制御機構2005

    • Author(s)
      岩間厚志
    • Journal Title

      炎症と免疫 13

      Pages: 72-79

    • Data Source
      KAKENHI-PROJECT-17659289
  • [Journal Article] ポリコーム遺伝子Bmi-1と幹細胞制御2005

    • Author(s)
      岩間厚志
    • Journal Title

      Molecular Medicine臨時増刊号「免疫2006」 42

      Pages: 23-27

    • Data Source
      KAKENHI-PROJECT-17659289
  • [Journal Article] siRNAを用いた標的遺伝子ノックダウンによる白血病治療の可能性2005

    • Author(s)
      岩間厚志
    • Journal Title

      血液腫瘍科 51

      Pages: 16-20

    • Data Source
      KAKENHI-PROJECT-16045202
  • [Journal Article] siRNA を用いた標的遺伝子ノックダウンによる白血病治療の可能性2005

    • Author(s)
      岩間厚志
    • Journal Title

      血液腫瘍科 51

      Pages: 16-20

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes (Review).2005

    • Author(s)
      Iwama A
    • Journal Title

      Int.J.Hematol. 81

      Pages: 294-300

    • Data Source
      KAKENHI-PROJECT-17054012
  • [Journal Article] 幹細胞の自己複製メカニズム2005

    • Author(s)
      岩間厚志
    • Journal Title

      最新医学 60

      Pages: 1740-1746

    • Data Source
      KAKENHI-PROJECT-17659289
  • [Journal Article] 幹細胞の自己複製メカニズム2005

    • Author(s)
      岩間厚志
    • Journal Title

      最新医学 60

      Pages: 1740-1746

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] ポリコーム遺伝子Bmi-1による造血幹細胞制御2005

    • Author(s)
      岩間厚志
    • Journal Title

      医学のあゆみ別冊「血液疾患ver.3」

      Pages: 55-58

    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] Stem cell regulation by a polycomb gene, Bmi-12005

    • Author(s)
      Iwama A.
    • Journal Title

      Molecular Medicine 42

      Pages: 133-139

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] Perspectives of siRNA-based leukemia therapy.2005

    • Author(s)
      Iwama A.
    • Journal Title

      Hematology & Oncology 51

      Pages: 16-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] Mechanism of stem cell self-renewal.2005

    • Author(s)
      Iwama A.
    • Journal Title

      Medical Frontline 60

      Pages: 1740-1746

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] siRNAを用いた標的遺伝子ノックダウンによる白血病治療の可能性2005

    • Author(s)
      岩間厚志
    • Journal Title

      血液腫瘍科 51

      Pages: 16-20

    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] ポリコーム遺伝子Bmi-1と幹細胞制御2005

    • Author(s)
      岩間厚志
    • Journal Title

      Molecular Medicine臨時増刊号「免疫2006」 42

      Pages: 23-27

    • Data Source
      KAKENHI-PROJECT-16045202
  • [Journal Article] siRNAを用いた標的遺伝子ノックダウンによる白血病治療の可能性2005

    • Author(s)
      岩間厚志
    • Journal Title

      血液腫瘍科 51

      Pages: 16-20

    • Data Source
      KAKENHI-PROJECT-17054012
  • [Journal Article] Role of Bmi-1 in tbe self-renewal of bematopoietic stem cells.2005

    • Author(s)
      Iwama A.
    • Journal Title

      Blood Diseases-state of arte Ver.3

      Pages: 55-58

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes (Review).2005

    • Author(s)
      Iwama A
    • Journal Title

      Int.J.Hematol. 81

      Pages: 294-300

    • Data Source
      KAKENHI-PROJECT-17659289
  • [Journal Article] ポリコーム遺伝子Bmi-1と幹細胞制御2005

    • Author(s)
      岩間厚志
    • Journal Title

      Molecular Medicine臨時増刊号「免疫2006」 42

      Pages: 133-139

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] ポリコーム遺伝子Bmi-1による造血幹細胞制御2005

    • Author(s)
      岩間厚志
    • Journal Title

      医学のあゆみ別冊「血液疾患ver.3」

      Pages: 55-58

    • Data Source
      KAKENHI-PROJECT-17659289
  • [Journal Article] 造血幹細胞の自己複製制御機構2005

    • Author(s)
      岩間厚志
    • Journal Title

      炎症と免疫 13

      Pages: 72-79

    • Data Source
      KAKENHI-PROJECT-17054012
  • [Journal Article] 造血幹細胞の自己複製制御機構2005

    • Author(s)
      岩間厚志
    • Journal Title

      炎症と免疫 13

      Pages: 72-79

    • Data Source
      KAKENHI-PROJECT-16045202
  • [Journal Article] Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes (Review).2005

    • Author(s)
      Iwama A
    • Journal Title

      Int.J.Hematol. 81

      Pages: 294-300

    • Data Source
      KAKENHI-PROJECT-16045202
  • [Journal Article] ポリコーム遺伝子Bmi-1による造血幹細胞制御2005

    • Author(s)
      岩間厚志
    • Journal Title

      医学のあゆみ別冊「血液疾患 ver.3」

      Pages: 55-58

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] siRNAを用いた標的遺伝子ノックダウンによる白血病治療の可能性2005

    • Author(s)
      岩間厚志
    • Journal Title

      血液腫瘍科 51

      Pages: 16-20

    • Data Source
      KAKENHI-PROJECT-17659289
  • [Journal Article] Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia.2004

    • Author(s)
      Yasuda T, Shirakata M, Iwama A, et al.
    • Journal Title

      J.Exp.Med. 200

      Pages: 1681-1687

    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] pDP4, a novel glycoprotein secreted by mature granulocytes is regulated by transcription factor PU.1.2004

    • Author(s)
      Rosenbauer F, Wagner K, Zhang P, Knobeloch K-P, Iwama A, et al.
    • Journal Title

      Blood 103

      Pages: 4294-4301

    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] Enhanced self-renewal of hematopoietic stem cells mediated by the Polycomb gene product, Bmi-1.2004

    • Author(s)
      Iwama A, Oguro H, et al.
    • Journal Title

      Immunity 21

      Pages: 843-851

    • Data Source
      KAKENHI-PROJECT-16045202
  • [Journal Article] Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia.2004

    • Author(s)
      Yasuda T, Shirakata M, Iwama A, et al.
    • Journal Title

      J.Exp.Med. 200

      Pages: 1681-1687

    • Data Source
      KAKENHI-PROJECT-16045202
  • [Journal Article] Enhanced self-renewal of hematopoietic stem cells mediated by the Polycomb gene product, Bmi-1.2004

    • Author(s)
      Iwama A, Oguro H, et al.
    • Journal Title

      Immunity 21

      Pages: 843-851

    • Data Source
      KAKENHI-PROJECT-16390273
  • [Journal Article] pDP4, a novel glycoprotein secreted by mature granulocytes is regulated by transcription factor PU.1.2004

    • Author(s)
      Rosenbauer F, Wagner K, Zhang P, Knobeloch K-P, Iwama A, et al.
    • Journal Title

      Blood 103

      Pages: 4294-4301

    • Data Source
      KAKENHI-PROJECT-16045202
  • [Journal Article] Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product, Bmi-1.2004

    • Author(s)
      Iwama A.et al.
    • Journal Title

      Immunity. 21

      Pages: 843-851

    • Data Source
      KAKENHI-PROJECT-14081202
  • [Journal Article] 3-deazaneplanocin is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells

    • Author(s)
      Chiba T, Suzuki E, Negishi M, Saraya A, Miyagi S, Konuma T, Tanaka S, Tada M, Kanai F, Imazeki F, Iwama A, Yokosuka O
    • Journal Title

      Int J Cancer

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Journal Article] Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma.

    • Author(s)
      Yonemitsu Y, Imazeki F, Chiba T, Fukai K, Nagai Y, Miyagi S, Arai M, Aoki R, Miyazaki M, Nakatani Y, Iwama A, Yokosuka O.
    • Journal Title

      Hum Pathol (in press.)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Presentation] Targeting Hippo pathway in bone marrow niche promotes hematopoietic regeneration.2024

    • Author(s)
      Atsushi Iwama
    • Organizer
      The 21st IRCMS Symposium on The Dynamics and Development of Normal and Malignant Hematopoietic Stem Cells.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] Aging of hematopoietic stem cells2024

    • Author(s)
      Atsushi Iwama
    • Organizer
      International Symposium on “Signals for Human, Animal and Planetary Health: From Metabolites To Biological Interactions”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] Targeting Hippo pathway in bone marrow niche promotes hematopoietic regeneration.2024

    • Author(s)
      Atsushi Iwama
    • Organizer
      The 21st IRCMS Symposium on The Dynamics and Development of Normal and Malignant Hematopoietic Stem Cells.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] Aging of hematopoietic stem cells2024

    • Author(s)
      Atsushi Iwama
    • Organizer
      International Symposium on “Signals for Human, Animal and Planetary Health: From Metabolites To Biological Interactions”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] TOPORS ubiquitin ligase promotes degradation of DNMT1 in the presence of DNA hypomethylating agents2023

    • Author(s)
      Atsushi Iwama
    • Organizer
      Tsuruoka Conference “Role of epigenetic factors in cancer”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] Chromatin accessibility in stem cells unveils progressive transcriptional reprogramming in myelodysplastic syndrome2023

    • Author(s)
      Atsushi Iwama
    • Organizer
      Symposia ”Revisiting epigenetics in cancer” The 82th Annual Meeting of the Japanese Cancer Association
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] TOPORS ubiquitin ligase promotes DNMT1 degradation upon DNA hypomethylating agents2023

    • Author(s)
      Atsushi Iwama
    • Organizer
      The 2nd International Symposium on REPLICATION of NON GENOME 2023
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] TOPORS ubiquitin ligase promotes DNMT1 degradation upon DNA hypomethylating agents2023

    • Author(s)
      Atsushi Iwama
    • Organizer
      The 2nd International Symposium on REPLICATION of NON GENOME 2023
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] TOPORS ubiquitin ligase promotes degradation of DNMT1 in the presence of DNA hypomethylating agents2023

    • Author(s)
      Atsushi Iwama
    • Organizer
      Tsuruoka Conference “Role of epigenetic factors in cancer”
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] Chromatin accessibility in stem cells unveils progressive transcriptional reprogramming in myelodysplastic syndrome2023

    • Author(s)
      Atsushi Iwama
    • Organizer
      Symposia ”Revisiting epigenetics in cancer” The 82th Annual Meeting of the Japanese Cancer Association
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease2022

    • Author(s)
      13.Ola Rizq, Naoya Mimura, Shuhei Koide, Motohiko Oshima, Shuji Momose, Yaeko Nakajima-Takagi, Kazumasa, Aoyama, Emiko Sakaida, Chiaki Nakaseko, Junichi Tamaru, Hiroaki Honda, Atsushi Iwama
    • Organizer
      The 81th Annual Meeting of the Japanese Cancer Association
    • Data Source
      KAKENHI-PROJECT-21K19497
  • [Presentation] Chromatin accessibility in MDS stem and progenitor cells. Symposium “Recent advances in leukemia stem cell research”2022

    • Author(s)
      Iwama A
    • Organizer
      The 84th Annual Meeting of the Japanese Society of Hematology
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] Chromatin accessibility in MDS stem and progenitor cells. Symposium “Recent advances in leukemia stem cell research”2022

    • Author(s)
      Iwama A
    • Organizer
      The 84th Annual Meeting of the Japanese Society of Hematology
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] 「造血幹細胞特性の加齢変化とエピジェネティックメモリー」シンポジウム「100歳を目指した健康寿命延伸医療の実現」2022

    • Author(s)
      岩間厚志
    • Organizer
      日本心血管作動部質学会
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] 「造血幹細胞特性の加齢変化とエピジェネティックメモリー」シンポジウム「100歳を目指した健康寿命延伸医療の実現」2022

    • Author(s)
      岩間厚志
    • Organizer
      日本心血管作動部質学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] Chromatin accessibility in MDS stem and progenitor cells. Hematopoiesis2021

    • Author(s)
      Atsushi Iwama
    • Organizer
      Keystone Symposia
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] Chromatin accessibility in MDS stem and progenitor cells. Hematopoiesis2021

    • Author(s)
      Atsushi Iwama
    • Organizer
      Keystone Symposia
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] Non-canonical PRC1 regulates homeostatic and emergency hematopoiesis by restricting myeloid differentiation program2021

    • Author(s)
      Atsushi Iwama
    • Organizer
      The Hematologic Malignancies Conference, FASEB Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] Non-canonical PRC1 regulates homeostatic and emergency hematopoiesis by restricting myeloid differentiation program2021

    • Author(s)
      Atsushi Iwama
    • Organizer
      The Hematologic Malignancies Conference, FASEB Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] KDM6A inactivation in germinal center B cells promotes the development of plasma cell neoplasms2020

    • Author(s)
      Atsushi Iwama
    • Organizer
      日本がん学会総会
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] 造血幹細胞のエピジェネティックプロファイリング2020

    • Author(s)
      岩間厚志
    • Organizer
      共同利用・共同研究拠点「マルチオミックスによる遺伝子発現制御の先端的医学共同研究拠点」シンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] 造血幹細胞のエピジェネティックプロファイリング2020

    • Author(s)
      岩間厚志
    • Organizer
      共同利用・共同研究拠点「マルチオミックスによる遺伝子発現制御の先端的医学共同研究拠点」シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] KDM6A inactivation in germinal center B cells promotes the development of plasma cell neoplasms2020

    • Author(s)
      Atsushi Iwama
    • Organizer
      日本がん学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] 造血幹細胞の加齢変化を規定するエピゲノム特性2019

    • Author(s)
      岩間厚志
    • Organizer
      第42回日本基礎老化学会大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] 造血幹細胞のエピジェネティックプロファイリング2019

    • Author(s)
      岩間厚志
    • Organizer
      共同利用・共同研究拠点「マルチオミックスによる遺伝子発現制御の先端的医学共同研究拠点」シンポジウム
    • Invited
    • Data Source
      KAKENHI-WRAPUP-19H05442
  • [Presentation] PRC1.1, a variant polycomb repressive complex 1 in normal and malignant hematopoiesis2019

    • Author(s)
      Atsushi Iwama
    • Organizer
      9th Biennial Workshop on the Clinical Translation of Epigenetics in Cancer Therapy
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-WRAPUP-19H05442
  • [Presentation] Epigenetic alterations in aged hematopoietic stem cells and age-associated malignancies2019

    • Author(s)
      Iwama A
    • Organizer
      第13回日本エピジェネティクス研究会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] PRC1.1, a variant polycomb repressive complex 1 in normal and malignant hematopoiesis2019

    • Author(s)
      Atsushi Iwama
    • Organizer
      9th Biennial Workshop on the Clinical Translation of Epigenetics in Cancer Therapy
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-26115001
  • [Presentation] PRC1.1, a variant polycomb repressive complex 1 in normal and malignant hematopoiesis2019

    • Author(s)
      Atsushi Iwama
    • Organizer
      9th Biennial Workshop on the Clinical Translation of Epigenetics in Cancer Therapy
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21751
  • [Presentation] PRC1.1, a variant polycomb repressive complex 1 in normal and malignant hematopoiesis2019

    • Author(s)
      Atsushi Iwama
    • Organizer
      9th Biennial Workshop on the Clinical Translation of Epigenetics in Cancer Therapy
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] UTX insufficiency in the pathogenesis of multiple myeloma2019

    • Author(s)
      Atsushi Iwama
    • Organizer
      2019 US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21751
  • [Presentation] Epigenetic alterations in aged hematopoietic stem cells and age-associated malignancies2019

    • Author(s)
      Iwama A
    • Organizer
      第13回日本エピジェネティクス研究会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K19555
  • [Presentation] UTX insufficiency in the pathogenesis of multiple myeloma2019

    • Author(s)
      Atsushi Iwama
    • Organizer
      2019 US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] 造血幹細胞の加齢変化を規定するエピゲノム特性2019

    • Author(s)
      岩間厚志
    • Organizer
      第42回日本基礎老化学会大会
    • Invited
    • Data Source
      KAKENHI-WRAPUP-19H05442
  • [Presentation] Epigenetic alterations in aged hematopoietic stem cells and age-associated malignancies2019

    • Author(s)
      岩間厚志
    • Organizer
      第42回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] Epigenetic alterations in aged hematopoietic stem cells and age-associated malignancies2019

    • Author(s)
      Iwama A
    • Organizer
      第62回日本放射線影響学会大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] 造血幹細胞の加齢変化を規定するエピゲノム特性2019

    • Author(s)
      岩間厚志
    • Organizer
      第42回日本基礎老化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K19555
  • [Presentation] Epigenetic alterations in aged hematopoietic stem cells and age-associated malignancies2019

    • Author(s)
      Iwama A
    • Organizer
      第62回日本放射線影響学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K19555
  • [Presentation] Epigenetic alterations in aged hematopoietic stem cells and age-associated malignancies2019

    • Author(s)
      Iwama A
    • Organizer
      第13回日本エピジェネティクス研究会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] Epigenetic alterations in aged hematopoietic stem cells and age-associated malignancies2019

    • Author(s)
      岩間厚志
    • Organizer
      第42回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-19H05746
  • [Presentation] Epigenetic alterations in aged hematopoietic stem cells and age-associated malignancies2019

    • Author(s)
      Iwama A
    • Organizer
      第42回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-WRAPUP-19H05442
  • [Presentation] Epigenetic alterations in aged hematopoietic stem cells and age-associated malignancies2019

    • Author(s)
      Atsushi Iwama
    • Organizer
      第13回日本エピジェネティクス研究会年会
    • Invited
    • Data Source
      KAKENHI-WRAPUP-19H05442
  • [Presentation] UTX insufficiency in the pathogenesis of multiple myeloma2019

    • Author(s)
      Atsushi Iwama
    • Organizer
      2019 US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-26115001
  • [Presentation] 造血幹細胞の加齢変化を規定するエピゲノム特性2019

    • Author(s)
      岩間厚志
    • Organizer
      第42回日本基礎老化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] Epigenetic alterations in aged hematopoietic stem cells and age-associated malignancies2019

    • Author(s)
      Iwama A
    • Organizer
      第62回日本放射線影響学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H05653
  • [Presentation] 造血幹細胞のエイジングと加齢関連腫瘍2018

    • Author(s)
      岩間厚志
    • Organizer
      帝京大学アジア国際感染制御研究所創設5周年記念国際シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21751
  • [Presentation] 造血幹細胞の加齢変化を規定するエピゲノム特性2018

    • Author(s)
      岩間厚志
    • Organizer
      第65回日本実験動物学会総会
    • Invited
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] PRC1.1, a variant polycomb repressive complex 1 in normal and malignant hematopoiesis2018

    • Author(s)
      Atsushi Iwama
    • Organizer
      McCulloch & Till Lecture Award, The 47th Annual Scientific Meeting, International Society for Experimental Hematology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-26115001
  • [Presentation] Loss of Utx with Braf V600E induces mature B-cell tumorigenesis in a conditional mouse model2018

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
    • Organizer
      第80回日本血液学会総会(大阪市)
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] Loss of Utx Cooperates with Braf V600E Mutation to Induce Post-Germinal Center B-cell Disorders in Mice2018

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Syuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
    • Organizer
      The 9th JSH international symposium (Kyoto, Japan)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] 造血幹細胞の加齢変化を規定するエピゲノム特性2018

    • Author(s)
      岩間厚志
    • Organizer
      第65回日本実験動物学会総会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-26115001
  • [Presentation] PRC1.1, a variant polycomb repressive complex 1 in normal and malignant hematopoiesis2018

    • Author(s)
      Atsushi Iwama
    • Organizer
      McCulloch & Till Lecture Award, The 47th Annual Scientific Meeting, International Society for Experimental Hematology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] 造血幹細胞の加齢変化を規定するエピゲノム特性2018

    • Author(s)
      岩間厚志
    • Organizer
      第65回日本実験動物学会総会
    • Invited
    • Data Source
      KAKENHI-INTERNATIONAL-15K21751
  • [Presentation] The loss of Bmi1 promotes age-associated changes in bone marrow niche cells2018

    • Author(s)
      Li-Bo Hou, Sha Si, Motohiko Oshima, Yuko Kato, Erico Nitta, Yaeko Nakajima, Satoshi Yamazaki, Atsushi Iwama
    • Organizer
      第15回幹細胞シンポジウム
    • Data Source
      KAKENHI-PROJECT-18K19555
  • [Presentation] 造血幹細胞のエイジングと加齢関連腫瘍2018

    • Author(s)
      岩間厚志
    • Organizer
      帝京大学アジア国際感染制御研究所創設5周年記念国際シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] 新規骨髄腫マウスモデルの作成2018

    • Author(s)
      リズクオラ, 三村尚也, 井関徹, 堺田惠美子, 中世古知昭, 岩間厚志
    • Organizer
      第43回日本骨髄腫学会学術集会 (千葉市)
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] Utx Insufficiency Cooperates with Braf V600E in the Induction of Myeloma in Mice2018

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
    • Organizer
      The 60th ASH annual meeting (SanDiego, USA)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] PRC1.1, a variant polycomb repressive complex 1 in normal and malignant hematopoiesis2018

    • Author(s)
      Atsushi Iwama
    • Organizer
      McCulloch & Till Lecture Award, The 47th Annual Scientific Meeting, International Society for Experimental Hematology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21751
  • [Presentation] 造血幹細胞のエイジングと加齢関連腫瘍2018

    • Author(s)
      岩間厚志
    • Organizer
      帝京大学アジア国際感染制御研究所創設5周年記念国際シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-26115001
  • [Presentation] 造血器腫瘍とエピジェネティクス2017

    • Author(s)
      岩間厚志
    • Organizer
      第76回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Presentation] 造血器腫瘍とエピジェネティクス2017

    • Author(s)
      岩間厚志
    • Organizer
      第76回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] 造血器腫瘍とエピジェネティクス2017

    • Author(s)
      岩間厚志
    • Organizer
      第76回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15498
  • [Presentation] ポリコーム群複合体による造血幹細胞のエピジェネティック制御2017

    • Author(s)
      岩間厚志
    • Organizer
      第65回 日本輸血・細胞治療学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15498
  • [Presentation] Ineffective erythropoiesis in myelodysplastic syndrome2017

    • Author(s)
      岩間厚志
    • Organizer
      第79回日本血液学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15498
  • [Presentation] 造血幹細胞のエピジェネティック制御2017

    • Author(s)
      岩間厚志
    • Organizer
      第27回 日本サイトメトリー学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] 造血幹細胞のエピジェネティック制御2017

    • Author(s)
      岩間厚志
    • Organizer
      第27回 日本サイトメトリー学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15498
  • [Presentation] ポリコーム群複合体による造血幹細胞のエピジェネティック制御2017

    • Author(s)
      岩間厚志
    • Organizer
      第65回 日本輸血・細胞治療学会総会
    • Invited
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] 造血幹細胞のエピジェネティック制御2017

    • Author(s)
      岩間厚志
    • Organizer
      第27回 日本サイトメトリー学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Presentation] Ineffective erythropoiesis in myelodysplastic syndrome2017

    • Author(s)
      岩間厚志
    • Organizer
      第79回日本血液学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Presentation] Ineffective erythropoiesis in myelodysplastic syndrome2017

    • Author(s)
      岩間厚志
    • Organizer
      第79回日本血液学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] ポリコーム群複合体による造血幹細胞のエピジェネティック制御2017

    • Author(s)
      岩間厚志
    • Organizer
      第65回 日本輸血・細胞治療学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Presentation] The loss of Ezh2 cooperates with an active JAK2 mutant in the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition2016

    • Author(s)
      Sashida G, Wang C, Oshima M, Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A
    • Organizer
      International Society for Experimental Hematology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-08-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461396
  • [Presentation] Deregulated polycomb function in the pathogenesis of MDS2016

    • Author(s)
      Iwama A
    • Organizer
      The 78th Annual Meeting of the Japanese Society of Hematology
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa
    • Year and Date
      2016-10-13
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Presentation] 造血幹細胞におけるバリアントPRC1複合体の機能2016

    • Author(s)
      岩間 厚志
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場、大阪府大阪市
    • Year and Date
      2016-03-17
    • Invited
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] Deregulated polycomb-group gene functions in hematological malignancies2016

    • Author(s)
      Iwama A
    • Organizer
      5th JCA-AACR Special Joint Conference.
    • Place of Presentation
      Tokyo Bay Maihama Hotel Club Restort, Urayasu, Chiba
    • Year and Date
      2016-07-13
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] Polycomb repressive complexes in hematological malignancies2016

    • Author(s)
      Iwama A
    • Organizer
      11th International Workshop on Melecular aspects of myeloid stem cell development and leukemia
    • Place of Presentation
      Cincinnati Children’s Hospital Medical Center,Ohio,U.S.A.
    • Year and Date
      2016-05-02
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15498
  • [Presentation] Dual inhibition of EZH2 and EZH1 sensitizes myeloma cells to bortezomib2016

    • Author(s)
      Ola Rizq、三村尚也、井関徹、中世古知昭、岩間厚志
    • Organizer
      第41回日本骨髄腫学会学術集会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2016-05-29
    • Data Source
      KAKENHI-PROJECT-26860719
  • [Presentation] Role of non-canonical polycomb repressive complex 1 in fate decision of hematopoietic stem cells.2016

    • Author(s)
      Iwama A
    • Organizer
      Annual Meeting of International Society of Stem Cell Research
    • Place of Presentation
      Moscone West, San Francisco,California, U.S.A.
    • Year and Date
      2016-06-22
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] Ezh2 loss promotes the transformation of ETP-ALL via suppressing T-cell differentiation regulators2016

    • Author(s)
      Sashida G, Wang C, Sato D, Oshima M, Matsui H, Nakajima-Takagi Y, Mochizuki-Kashio M, Iwama A
    • Organizer
      日本血液学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-26461396
  • [Presentation] PRC2 Inhibition Sensitizes Myeloma Cells to Proteasome Inhibitor.2016

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Changshan Wang, Tetsuhiro Chiba, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama.
    • Organizer
      The 5th Japanese Cancer Association (JCA) - American Association for Cancer Research (AACR) Special Joint Conference
    • Place of Presentation
      Tokyo Bay Maihama Hotel Club Resort(千葉県浦安市)
    • Year and Date
      2016-07-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] Molecular mechanism behind the synergistic activity of proteasome inhibition and PRC2 inhibition in the treatment of multiple myeloma.2016

    • Author(s)
      14.Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama.
    • Organizer
      The 58th Annual Meeting of the American Society of Hematology
    • Place of Presentation
      San Diego Convention Center, California, USA
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] Deregulated polycomb function in the pathogenesis of MDS2016

    • Author(s)
      Iwama A
    • Organizer
      The 78th Annual Meeting of the Japanese Society of Hematology
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa
    • Year and Date
      2016-10-13
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] Role of non-canonical polycomb repressive complex 1 in fate decision of hematopoietic stem cells.2016

    • Author(s)
      Iwama A
    • Organizer
      Annual Meeting of International Society of Stem Cell Research
    • Place of Presentation
      Moscone West, San Francisco,California, U.S.A.
    • Year and Date
      2016-06-22
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Presentation] Role of polycomb-group complexes in hematopoietic stem aging and disease2016

    • Author(s)
      Iwama A
    • Organizer
      1st International Symposium on Stem Cell Aging and Disease.
    • Place of Presentation
      Ito Hall, the University of Tokyo,Tokyo
    • Year and Date
      2016-06-29
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Presentation] Role of polycomb-group complexes in hematopoietic stem aging and disease2016

    • Author(s)
      Iwama A
    • Organizer
      1st International Symposium on Stem Cell Aging and Disease.
    • Place of Presentation
      Ito Hall, the University, of Tokyo, Tokyo
    • Year and Date
      2016-06-29
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] Polycomb repressive complexes in hematological malignancies2016

    • Author(s)
      Iwama A
    • Organizer
      11th International Workshop on Melecular aspects of myeloid stem cell development and leukemia.
    • Place of Presentation
      Cincinnati Children’s Hospital Medical Center,Ohio,U.S.A.
    • Year and Date
      2016-05-02
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] Combined inhibition of PRC2 and proteasome as a potential therapy for multiple myeloma2016

    • Author(s)
      Ola Rizq, 三村尚也, 大島基彦, 更屋敦則, 小出周平, 加藤裕子, 青山和正, 井関徹, 中世古知昭, 岩間厚志
    • Organizer
      第78回日本血液学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] Polycomb repressive complexes in hematological malignancies2016

    • Author(s)
      Iwama A
    • Organizer
      11th International Workshop on Melecular aspects of myeloid stem cell development and leukemia.
    • Place of Presentation
      Cincinnati Children’s Hospital Medical Center,Ohio,U.S.A.
    • Year and Date
      2016-05-02
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Presentation] 造血幹細胞におけるバリアントPRC1複合体の機能2016

    • Author(s)
      岩間 厚志
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場,大阪府大阪市
    • Year and Date
      2016-03-17
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Presentation] Deregulated polycomb-group gene functions in hematological malignancies2016

    • Author(s)
      Iwama A
    • Organizer
      5th JCA-AACR Special Joint Conference.
    • Place of Presentation
      Tokyo bay Maihama Hotel Club Resort, Urayasu, Chiba
    • Year and Date
      2016-07-13
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02544
  • [Presentation] EZH2・EZH1阻害剤は骨髄腫細胞のボルテゾミブ感受性を増強する2016

    • Author(s)
      Ola Rizq, 三村尚也, 井関徹, 中世古知昭, 岩間厚志
    • Organizer
      第41回日本骨髄腫学会学術集会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2016-05-28
    • Data Source
      KAKENHI-PROJECT-16K09839
  • [Presentation] ヒストンメチル化による肝幹細胞の分化制御機構の検討2015

    • Author(s)
      千葉哲博, 岩間厚志, 横須賀收
    • Organizer
      日本消化器関連学会週間
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-25460977
  • [Presentation] Synergistic activity of a novel EZH2 inhibitor UNC1999 and bortezomib in multiple myeloma2015

    • Author(s)
      Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuhei Koide, Tohru Iseki, Chiaki Nakaseko and Atsushi Iwama
    • Organizer
      第77回日本血液学会学術集会
    • Place of Presentation
      ホテル日航金沢(石川県金沢市)
    • Year and Date
      2015-10-16
    • Data Source
      KAKENHI-PROJECT-26860719
  • [Presentation] Ezh2 Loss Promotes the Transformation of Early T Cell Precursor Leukemia Via Suppressing Critical Genes for T-Cell Differentiation2015

    • Author(s)
      Goro Sashida, Changshan Wang, Daisuke Sato, Motohiko Oshima, Atsushi Iwama
    • Organizer
      アメリカ血液学会年次総会
    • Place of Presentation
      米国オーランド
    • Year and Date
      2015-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461396
  • [Presentation] EZH2阻害による多発性骨髄腫の新規治療戦略2015

    • Author(s)
      三村尚也、Ola Rizq、井関徹、中世古知昭、岩間厚志
    • Organizer
      第40回日本骨髄腫学会学術集会
    • Place of Presentation
      くまもと森都心プラザ(熊本県熊本市)
    • Year and Date
      2015-05-17
    • Data Source
      KAKENHI-PROJECT-26860719
  • [Presentation] EZH2 Inhibition and the Combination with Proteasome Inhibition Are Novel Potential Strategies for the Treatment of Multiple Myeloma2014

    • Author(s)
      Ola Rizq, Naoya Mimura, Shuhei Koide, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, Atsushi Iwama
    • Organizer
      第56回アメリカ血液学会年次総会
    • Place of Presentation
      Moscone Center (米国サンフランシスコ)
    • Year and Date
      2014-12-06
    • Data Source
      KAKENHI-PROJECT-26860719
  • [Presentation] Critical role of SOX17 in hematopoietic development from human embryonic stem cells2013

    • Author(s)
      Osawa M, Nakajima Y, Oshima M, Takagi H, Iwama A.
    • Organizer
      CiRA International Symposium
    • Place of Presentation
      Kyoto,Japan(oral)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] 「MDS発症におけるポリコーム遺伝子EZH2の」関 与」2013

    • Author(s)
      武藤朋也, 岩間厚志
    • Organizer
      第17回造血器腫瘍研究会兼、がん研究 開発費「がん幹細胞に対する新規分子法的治 療薬の開発を目指した基盤研究」班会議
    • Place of Presentation
      宮崎(オーラル)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders2013

    • Author(s)
      Iwama A.
    • Organizer
      The 72th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PUBLICLY-25130702
  • [Presentation] LR11 plays critical roles in leukemogenesis of AML by regulating cell adhesion and homing ability2013

    • Author(s)
      西居圭吾、中世古知昭、武内正博、清水直美、大和田千佳子、塚本祥吉、川口岳晴、姜美子、岩間厚志、武城英明
    • Organizer
      第75回日本血液学会総会
    • Year and Date
      2013-10-11
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] Critical role of SOX17 in hematopoietic development from human embryonic stem cells2013

    • Author(s)
      Osawa M, Nakajima Y, Oshima M, Takagi H, Iwama A.
    • Organizer
      Keystone Symposium : Hematopoiesis
    • Place of Presentation
      Corolado, U.S.A (poster)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders2013

    • Author(s)
      Iwama A.
    • Organizer
      The 72th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-24249054
  • [Presentation] Loss of Ezh2 promotes the development of mutant-RUNX1 induced MDS2012

    • Author(s)
      Sashida G, Tanaka S, Mochizuki-Kashio M, Saraya A, Muto T, Iwama A.
    • Organizer
      54^<th> ASH Annual Meeting and Exposition
    • Place of Presentation
      Atlanta, U.S.A. (Oral)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] ヒト造血幹細胞の体外増幅の可能性2012

    • Author(s)
      岩間厚志
    • Organizer
      第34回日本造血細胞移植学会総会
    • Place of Presentation
      大阪国際会議場(招待講演)
    • Year and Date
      2012-02-24
    • Data Source
      KAKENHI-PUBLICLY-23130502
  • [Presentation] Bmil confers resistance to oxidative stress on hematopoietic stem cells2012

    • Author(s)
      Oshima M, Nakamura S, Saraya A, Miyagi S, Koseki H, Iwama A
    • Organizer
      ISSCR the 10^<th> Annual Meeting.
    • Place of Presentation
      Yokohama,Japan(Poster)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] ヒト造血幹細胞の体外増幅の可能性2012

    • Author(s)
      岩間厚志
    • Organizer
      第34回日本造血細胞移植学会総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] Role of the polycomb group proteins in the maintenance of hematopoietic stem cells and restriction of tumor development.2012

    • Author(s)
      Iwama A
    • Organizer
      The 74th Annual Meeting of the Japanese Society of Hematology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2012-10-19
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-23130502
  • [Presentation] Critical role of SOX17 in the hematopoietic development from human embryonic stem cells2012

    • Author(s)
      Osawa M, Nakajima Y, Oshima M, Takagi H, Endoh M, Endo T, Iwama A
    • Organizer
      The 10^<th> Stem Cell Research Symposium.
    • Place of Presentation
      Awaji,Japan(Oral)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] Role of the polycomb group proteins in the maintenance of hematopoietic stem cells and restriction of tumor development2012

    • Author(s)
      Iwama A.
    • Organizer
      41^<st> Annual Scientific Meeting of the ISEH.
    • Place of Presentation
      Amsterdam, Netherlands(Oral)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] Role of the polycomb group proteins in the maintenance of hematopoietic stem cells and restriction of tumor development2012

    • Author(s)
      Iwama A.
    • Organizer
      The 74^<th> Annual Meeting of the Japanese Society of Hematology.
    • Place of Presentation
      Kyoto, Japan(Oral)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] Role of the polycomb group proteins in the maintenance of hematopoietic stem cells and restriction of tumor development2012

    • Author(s)
      Iwama A.
    • Organizer
      IMSUT & RCAST Global COE Program Mini-Symposium
    • Place of Presentation
      Tokyo,Japan(Oral)
    • Year and Date
      2012-06-18
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] Hbo1-Brd1/Brpf2複合体は、H3K14のローバルなアセチル化を引き起こし、胎生期肝における赤血球造血に必須である」2012

    • Author(s)
      宮城聡、岩間厚志
    • Organizer
      第8回麒麟塾
    • Place of Presentation
      東京(オーラル)
    • Year and Date
      2012-07-07
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes2012

    • Author(s)
      Iwama A.
    • Organizer
      The 10^<th> Stem Cell Research Symposium.
    • Place of Presentation
      Awaji,Japan(Oral)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] ヒト造血幹細胞の体外増幅の可能性2012

    • Author(s)
      岩間厚志
    • Organizer
      第34回日本造血細胞移植学会総会
    • Place of Presentation
      大阪国際会議場(招待講演)
    • Year and Date
      2012-02-24
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] ヒトES細胞からの造血細胞分化におけるSOX17の役割2012

    • Author(s)
      中島やえ子、岩間厚志
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都(オーラル)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] 胎生期の造血幹細胞と成体の造血幹細胞とでは、ポリコーム遺伝子Ezh2への依存性が異なる2012

    • Author(s)
      望月牧子、岩間厚志
    • Organizer
      第8回麒麟塾
    • Place of Presentation
      東京(オーラル)
    • Year and Date
      2012-07-07
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] Role of the polycomb group proteins in the maintenance of hematopoietic stem cells and restriction of tumor development2012

    • Author(s)
      Iwama A
    • Organizer
      41st Annual Scientific Meeting of the ISEH
    • Place of Presentation
      Amsterdam
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249054
  • [Presentation] Role of the polycomb group proteins in the maintenance of hematopoietic stem cells and restriction of tumor development.2012

    • Author(s)
      Iwama A
    • Organizer
      41st Annual Scientific Meeting of the ISEH
    • Place of Presentation
      Amsterdam, Netherland
    • Year and Date
      2012-08-23
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-23130502
  • [Presentation] Inhibition of TGF-BETA signaling in the early mesoderm stage promotes the development of hematopoietic progenitors from human embryonic stem cells2012

    • Author(s)
      Osawa M, Takagi H, Nakajima Y, Endoh M, Endo T, Iwama A
    • Organizer
      ISSCR 10^<th> Annual Meeting.
    • Place of Presentation
      Yokohama,Japan(Poster)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] The role of long intergenic non-coding RNAs in hematopoietic stem cells2012

    • Author(s)
      Wendt G, Iwama A
    • Organizer
      The 74th Annual Meeting of the Japanese Society of Hematology.
    • Place of Presentation
      Kyoto, Japan (Poster)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] Role of the polycomb group proteins in the maintenance of hematopoietic stem cells and restriction of tumor development.2012

    • Author(s)
      Iwama A
    • Organizer
      The 74th Annual Meeting of the Japanese Society of Hematology
    • Place of Presentation
      Kyoto
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249054
  • [Presentation] Radiation effects on human HSPCs in vivo2012

    • Author(s)
      Wang C, Nakamura S, Kusunoki Y, Kyoizumi S, Imai K, Nakachi K, Iwama A
    • Organizer
      The 74^<th> Annual Meeting of the Japanese Society ofHematology.
    • Place of Presentation
      Kyoto, Japan (Poster)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] The critical role of SOX17 in the development of early hematopoietic progenitors from human embryonic stem cells2012

    • Author(s)
      Nakajima-Takagi Y, Osawa M, Oshima M, Takagi H, Iwama A
    • Organizer
      ISSCR the 10^<th> Annual Meeting.
    • Place of Presentation
      Yokohama,Japan(Poster)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] Long-Term cell automomous effect of Tet2 loss in hematopoietic cells in mice2012

    • Author(s)
      Muto T, Sashida G, Oshima M, Nakaseko C, Yokote K, Shimoda K, Iwama A
    • Organizer
      54^<th> AHS Annual Meeting and Exposition
    • Place of Presentation
      Atlanta, U.S.A.(Poster)
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] 「ヒストン修飾による造血幹細胞の機能制御」シンポジウム「幹細胞の転写制御、エピジェネティック制御」2012

    • Author(s)
      岩間厚志
    • Organizer
      第33回日本炎症・再生医学会
    • Place of Presentation
      福岡(オーラル)
    • Year and Date
      2012-07-05
    • Data Source
      KAKENHI-PROJECT-23659483
  • [Presentation] 造血幹細胞のエピジェネティクス2011

    • Author(s)
      岩間厚志
    • Organizer
      第32回日本炎症・再生医学会
    • Place of Presentation
      京都
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] 教育講演「造血器腫瘍のエピゲノム」2011

    • Author(s)
      岩間厚志
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-14
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] ワークショップ「ヒト造血幹細胞の体外増幅の可能性」2011

    • Author(s)
      岩間厚志
    • Organizer
      第34回日本造血細胞移植学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2011-02-24
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] 教育講演「血液疾患とEpigenetics」2011

    • Author(s)
      岩間厚志
    • Organizer
      第96回近畿血液学地方会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-20
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] 造血幹細胞のエピジェネティクス2011

    • Author(s)
      岩間厚志
    • Organizer
      第32回日本炎症・再生医学会
    • Place of Presentation
      国立京都国際会館(招待講演)
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PUBLICLY-23130502
  • [Presentation] ヒト造血幹細胞の体外増幅の可能性2011

    • Author(s)
      岩間厚志
    • Organizer
      第21回日本サイトメトリー学会
    • Place of Presentation
      京都市国際交流会館(招待講演)
    • Year and Date
      2011-06-25
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] 造血幹細胞のエピジェネティクス2011

    • Author(s)
      岩間厚志
    • Organizer
      第32回 日本炎症・再生医学会
    • Place of Presentation
      国立京都国際会館(招待講演)
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] Regulation of liver cancer stem cells by polycomb group proteins.2011

    • Author(s)
      千葉哲博、岩間厚志、横須賀収
    • Organizer
      第3回JCA-AACR Special Joint Conference
    • Place of Presentation
      千葉県
    • Year and Date
      2011-03-04
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Presentation] 関連分野セミナー「エピジェネティクスupdate」2011

    • Author(s)
      岩間厚志
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] ヒト造血幹細胞の体外増幅の可能性2011

    • Author(s)
      岩間厚志
    • Organizer
      第21回日本サイトメトリー学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2011-06-25
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] Polycomb complexes in normal and abnormal hematopoiesis2011

    • Author(s)
      Iwama A
    • Organizer
      USA-Japan Cooperative Cancer Research Workshop
    • Place of Presentation
      Hayama
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] ヒト造血幹細胞の体外増幅の可能性2011

    • Author(s)
      岩間厚志
    • Organizer
      第21回日本サイトメトリー学会
    • Place of Presentation
      京都市国際交流会館(招待講演)
    • Year and Date
      2011-06-25
    • Data Source
      KAKENHI-PUBLICLY-23130502
  • [Presentation] 新規標的分子としてのポリコーム複合体2010

    • Author(s)
      岩間厚志
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-09-29
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] ポリコーム複合体による造血幹細胞の多能性維持機構2010

    • Author(s)
      岩間厚志
    • Organizer
      第9回日本再生医療学会総会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] Role of polycomb group proteins in the maintenance of self-renewal capacity and multipotency of hematopoietic stem cells.2010

    • Author(s)
      岩間厚志
    • Organizer
      第33回MCS23日本分子生物学会年会・第83回日本生化学会大会合同大会シンポジウム「発生・分化におけるエピジェネティクス制御」
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] Role of the polycomb proteins in normal and cancer stem cells.2010

    • Author(s)
      Iwama A.
    • Organizer
      The 15^<th>Samsung International Symposium on Molecular Medicine. "Cancer metastasis and cancer stem cell biology"
    • Place of Presentation
      Seoul
    • Year and Date
      2010-10-08
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] Role of polycomb group proteins in the maintenance of self-renewal capacity and multipotency of hematopoietic stem cells2010

    • Author(s)
      岩間厚志
    • Organizer
      第33回MCS23日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] Role of the polycomb proteins in normal and cancer stem cells2010

    • Author(s)
      Iwama A
    • Organizer
      The 15th Samsung International Symposium on Molecular Medicine
    • Place of Presentation
      Seoul
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] Regulation of hematopoietic stem cells by the polycomb repressive complexes2010

    • Author(s)
      Iwama A
    • Organizer
      International conference on stem cells and cancer (ICSCC-2010)
    • Place of Presentation
      Pune, India
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] 新規標的分子としてのポリコーム複合体2010

    • Author(s)
      岩間厚志
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] Brdl/Brpf2 is a core component of the Hbol HAT complex and regulates fetal liver erythropoiesis.2010

    • Author(s)
      Iwama A.
    • Organizer
      The 17th international Runx-workshop.
    • Place of Presentation
      Hiroshima
    • Year and Date
      2010-07-12
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] 幹細胞とエピジェネティクス2009

    • Author(s)
      岩間厚志
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20052009
  • [Presentation] 肝臓における正常幹細胞および癌幹細胞システムの制御機構2009

    • Author(s)
      千葉哲博、岩間厚志
    • Organizer
      第17回日本消化器病学会関連週間
    • Place of Presentation
      京都府
    • Year and Date
      2009-10-15
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Presentation] 癌幹細胞システムと癌治療2009

    • Author(s)
      岩間厚志
    • Organizer
      第27回日本口腔腫瘍学会総会教育講演
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-01-29
    • Data Source
      KAKENHI-PROJECT-20052009
  • [Presentation] 癌幹細胞システムと癌治療2009

    • Author(s)
      岩間厚志
    • Organizer
      第27回日本口腔腫瘍学会総会教育講演
    • Place of Presentation
      宇都宮
    • Year and Date
      2009-01-29
    • Data Source
      KAKENHI-PROJECT-19659463
  • [Presentation] 癌幹細胞のエピジェネティクスとポリコーム遺伝子2009

    • Author(s)
      岩間厚志
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] Bmil is essential for leukemic reprogramming of myeloid progenitor cells2009

    • Author(s)
      岩間厚志
    • Organizer
      51st ASH Annual Meeting and Exposition
    • Place of Presentation
      Ernest N.Morial Convention Center(USA)
    • Year and Date
      2009-11-09
    • Data Source
      KAKENHI-PROJECT-20052009
  • [Presentation] Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmil2009

    • Author(s)
      岩間厚志
    • Organizer
      2009 ISEH 38th Annual Scientific Meeting
    • Place of Presentation
      ATHENS Hotel Divani Caravel(ギリシャ)
    • Year and Date
      2009-09-12
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmil2009

    • Author(s)
      岩間厚志
    • Organizer
      2009 ISEH 38th Annual Scientific Meeting
    • Place of Presentation
      ATHENS Hotel Divani Caravel(ギリシャ)
    • Year and Date
      2009-09-12
    • Data Source
      KAKENHI-PROJECT-20052009
  • [Presentation] Regulatory machinery of Bmil in both normal and cancer stem cells in liver2009

    • Author(s)
      千葉哲博、青木竜太郎、横須賀収、岩間厚志
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      神奈川県
    • Year and Date
      2009-10-02
    • Data Source
      KAKENHI-PROJECT-21790649
  • [Presentation] Bmil is essential for leukemic reprogramming of myeloid progenitor cells2009

    • Author(s)
      岩間厚志
    • Organizer
      51st ASH Annual Meeting and Exposition
    • Place of Presentation
      Ernest N.Morial Convention Center(USA)
    • Year and Date
      2009-11-09
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] 新規標的分子としてのポリコーム複合体2009

    • Author(s)
      岩間厚志
    • Organizer
      第71回日本血液学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] 幹細胞とエピジェネティクス2009

    • Author(s)
      岩間厚志
    • Organizer
      第82回日本化学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] 新規標的分子としてのポリコーム複合体2009

    • Author(s)
      岩間厚志
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-21390289
  • [Presentation] 新規標的分子としてのポリコーム複合体2009

    • Author(s)
      岩間厚志
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-20052009
  • [Presentation] Regulation of cancer stem cell self-renewal by the polycomb gene Bmil2008

    • Author(s)
      Iwama A.
    • Organizer
      The 6th Annual Meeting of Japanese Society of Medical Oncology
    • Place of Presentation
      Fukuoka
    • Year and Date
      2008-03-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390277
  • [Presentation] ポリコーム複合体による幹細胞機能のエピジェネティック制御2008

    • Author(s)
      岩間厚志
    • Organizer
      第81回日本生化学会大会合同大会シンポジウム「翻訳後修飾系によるクロマチンの動態制御」
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-09
    • Data Source
      KAKENHI-PROJECT-19659463
  • [Presentation] 前駆細胞が癌幹細胞化する過程における自己複製制御分子Bmi1の機能2008

    • Author(s)
      岩間厚志
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-03-13
    • Data Source
      KAKENHI-PROJECT-18013008
  • [Presentation] The polycomb gene product Bmil is essential for the tumor-initiating capacity of hepatocellular carcinoma cells.2008

    • Author(s)
      岩間厚志
    • Organizer
      第5回国際幹細胞学会
    • Place of Presentation
      Cairns Convention Centre
    • Year and Date
      2008-06-17
    • Data Source
      KAKENHI-PROJECT-18055006
  • [Presentation] The polycomb gene product Bmil is essential for the tumor-initiating capacity of hepatocellular carcinoma cells2008

    • Author(s)
      岩間 厚志
    • Organizer
      第5回国際幹細胞学会
    • Place of Presentation
      Cairns Convention Centre
    • Year and Date
      2008-06-17
    • Data Source
      KAKENHI-PROJECT-18390277
  • [Presentation] ポリコーム遺伝子Bmilによる癌幹細胞の自己複製制御2008

    • Author(s)
      岩間厚志
    • Organizer
      第6回日本臨床腫瘍学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-03-20
    • Data Source
      KAKENHI-PROJECT-18055006
  • [Presentation] 前駆細胞が癌幹細胞化する過程における自己複製制御分子Bmilの機能2008

    • Author(s)
      岩間厚志
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-03-13
    • Data Source
      KAKENHI-PROJECT-18051005
  • [Presentation] 前駆細胞が癌幹細胞化する過程における自己複製制御分子Bmi1の機能2008

    • Author(s)
      岩間 厚志
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-03-13
    • Data Source
      KAKENHI-PROJECT-18390277
  • [Presentation] 前駆細胞が癌幹細胞化する過程における自己複製制御分子Bmilの機能2008

    • Author(s)
      岩間厚志
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-03-13
    • Data Source
      KAKENHI-PROJECT-18055006
  • [Presentation] Unexpected role for the polycomb gene Bmil in lymphocyte commitment2008

    • Author(s)
      岩間厚志
    • Organizer
      第38回日本免疫学会総会シンポジウム「Immunedevelopment」
    • Place of Presentation
      京都国際会場
    • Year and Date
      2008-12-02
    • Data Source
      KAKENHI-PROJECT-20052009
  • [Presentation] The polycomb gene product Bmil is essential for the tumor-initiating capacity of hepatocellular carcinoma cells.2008

    • Author(s)
      岩間厚志
    • Organizer
      第5回国際幹細胞学会
    • Place of Presentation
      Cairns Convention Centre
    • Year and Date
      2008-06-17
    • Data Source
      KAKENHI-PROJECT-18051005
  • [Presentation] ポリコーム複合体による幹細胞機能のエピジェネティック制御2008

    • Author(s)
      岩間厚志
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会シンポジウム「翻訳後修飾系によるクロマチンの動態制御」
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-09
    • Data Source
      KAKENHI-PROJECT-20052009
  • [Presentation] 肝臓における癌幹細胞システムの成立・維持メカニズム2008

    • Author(s)
      千葉哲博、横須賀收、岩間厚志
    • Organizer
      第16回日本消化器病学会関連週間
    • Place of Presentation
      東京都
    • Year and Date
      2008-10-01
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Presentation] ポリコーム遺伝子Bmilによる癌幹細胞の自己複製制御2008

    • Author(s)
      岩間厚志
    • Organizer
      第6回日本臨床腫瘍学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-03-20
    • Data Source
      KAKENHI-PROJECT-18051005
  • [Presentation] ポリコーム複合体による幹細胞機能のエピジェネティック制御2008

    • Author(s)
      岩間厚志
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-09
    • Data Source
      KAKENHI-PROJECT-19659463
  • [Presentation] Molecular machinery in the establishment and maintenance of liver cancer stem cell system.2008

    • Author(s)
      千葉哲博、宮城聡、横須賀收、岩間厚志
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      愛知県
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Presentation] Unexpected role for the polycomb gene Bmil in lymphocyte commitment2008

    • Author(s)
      岩間厚志
    • Organizer
      第38回日本免疫学会総会シンポジウム「Immune development」
    • Place of Presentation
      京都国際会場
    • Year and Date
      2008-12-02
    • Data Source
      KAKENHI-PROJECT-19659463
  • [Presentation] The polycomb gene product Bmil is essential for the tumor-initiating capacity of hepatocellular carcinoma cells.2008

    • Author(s)
      岩間厚志
    • Organizer
      第5回国際幹細胞学会
    • Place of Presentation
      Cairns Convention Centre
    • Year and Date
      2008-06-17
    • Data Source
      KAKENHI-PROJECT-18013008
  • [Presentation] ポリコーム遺伝子Bmi1による癌幹細胞の自己複製制御2008

    • Author(s)
      岩間 厚志
    • Organizer
      第6回日本臨床腫瘍学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-03-20
    • Data Source
      KAKENHI-PROJECT-18390277
  • [Presentation] 前駆細胞が癌幹細胞化する過程における自己複製制御分子Bmi1の機能2008

    • Author(s)
      岩間 厚志
    • Organizer
      第7回日本再生医療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-13
    • Data Source
      KAKENHI-PROJECT-19659463
  • [Presentation] ポリコーム遺伝子Bmi1による癌幹細胞の自己複製制御2008

    • Author(s)
      岩間厚志
    • Organizer
      第6回日本臨床腫瘍学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-03-20
    • Data Source
      KAKENHI-PROJECT-18013008
  • [Presentation] ポリコーム遺伝子Bmi1による癌幹細胞の自己複製制御2008

    • Author(s)
      岩間 厚志
    • Organizer
      第6回日本臨床腫瘍学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-20
    • Data Source
      KAKENHI-PROJECT-19659463
  • [Presentation] ポリコーム遺伝子Bmilこよる癌幹細胞の自己複製制御2008

    • Author(s)
      岩間厚志
    • Organizer
      第6回日本臨床腫瘍学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2008-03-20
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390277
  • [Presentation] Self-renewal machineries operating in both hematopoietic and leukemic stem cells2007

    • Author(s)
      Iwama A
    • Organizer
      The 69th Annual Meeting of Japanese Society of Hematology
    • Place of Presentation
      Pacifico Yokohama
    • Year and Date
      2007-10-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390277
  • [Presentation] A polycomb gene product Bmil regulates self-renewal of both normal tissue stem cells and cancer stem cells2007

    • Author(s)
      Iwama A
    • Organizer
      The 30th Annual Meeting of Japanese Society Molecular Biology
    • Place of Presentation
      Pacifico Yokohama
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390277
  • [Presentation] ポリコーム遺伝子Bmilによる組織幹細胞と癌幹細胞の自己複製制御2007

    • Author(s)
      岩間厚志
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-12-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390277
  • [Presentation] Investigation of cancer stem cell system in hepatocellular carcinoma.2007

    • Author(s)
      Chiba T, Miyagi S, Yokosuka O, Taniguchi H, Nakauchi H, Iwama A.
    • Organizer
      17th APASL conference
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2007-03-29
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Presentation] Self-renewing machineries operating in both hematopoietic and leukemic stem cells2007

    • Author(s)
      岩間厚志
    • Organizer
      第69回日本血液学会シンポジウム
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-12
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390277
  • [Presentation] The polycomb gene product BMI1 is required for the tumor-initiating capacity of hepatocellular carcinoma cells.2007

    • Author(s)
      千葉哲博、宮城聡、横須賀收、岩間厚志
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      神奈川県
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19790468
  • [Presentation] Role of polycomb group genes in hematological malignancies

    • Author(s)
      Atsushi Iwama
    • Organizer
      International Conference on the 19th Annual Meeting of Korean Society of Cancer Prevention
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-12-12 – 2014-12-13
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249054
  • [Presentation] Role of polycomb group genes in the pathogenesis of myeloid malignancies

    • Author(s)
      Atsushi Iwama
    • Organizer
      EMBO Workshop "Stem Cells and Epigenetics in Cancer"
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2014-10-16 – 2014-10-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249054
  • [Presentation] Epigenetic regulation of hematopoietic stem cells

    • Author(s)
      Atsushi Iwama
    • Organizer
      International Forum on Stem Cells
    • Place of Presentation
      Tianjin, China
    • Year and Date
      2014-11-01 – 2014-11-03
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249054
  • [Presentation] ヒストン修飾による造血幹細胞の機能制御

    • Author(s)
      岩間厚志
    • Organizer
      第36回MCS23日本分子生物学会年会ワークショップ「細胞系譜とエピゲノムダイナミクス」
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PUBLICLY-25130702
  • [Presentation] Role of polycomb group genes in hematological malignancies

    • Author(s)
      Atsushi Iwama
    • Organizer
      International Conference on the 19th Annual Meeting of Korean Society of Cancer Prevention
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-12-12 – 2014-12-13
    • Invited
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] Stem cell maintenance and amplification

    • Author(s)
      Atsushi Iwama
    • Organizer
      The 76th Annual Meeting of the Japanese Society of Hematology
    • Place of Presentation
      大阪国際会議場、大阪府大阪市
    • Year and Date
      2014-10-31 – 2014-11-02
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249054
  • [Presentation] Ezh2 loss accelerates JAK2V617F-driven primary myelofibrosis

    • Author(s)
      Sashida G, Tomioka T, Wang C, Shide K, Shimoda K, Iwama A.
    • Organizer
      日本血液学会総会
    • Place of Presentation
      大阪・大阪国際会議場
    • Year and Date
      2014-10-31 – 2014-11-02
    • Data Source
      KAKENHI-PROJECT-26461396
  • [Presentation] ヒストン修飾による造血幹細胞の機能制御

    • Author(s)
      岩間厚志
    • Organizer
      第36回MCS23日本分子生物学会年会ワークショップ「細胞系譜とエピゲノムダイナミクス」
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24249054
  • [Presentation] Stem cell maintenance and amplification

    • Author(s)
      Atsushi Iwama
    • Organizer
      The 76th Annual Meeting of the Japanese Society of Hematology
    • Place of Presentation
      大阪国際会議場、大阪府大阪市
    • Year and Date
      2014-10-31 – 2014-11-02
    • Invited
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] LR11 plays a critical role in leukemogenesis of AML by regulating cell adhes ion and homing ability

    • Author(s)
      西居桂吾、中世古知昭、武内正博、清水直美、大和田千桂子、塚本祥吉、川口岳晴、姜美子、岩間厚志 、武城英明
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23591368
  • [Presentation] Role of polycomb group genes in the pathogenesis of myeloid malignancies

    • Author(s)
      Atsushi Iwama
    • Organizer
      EMBO Workshop in Hong Kong
    • Place of Presentation
      Hong Kong University, China
    • Year and Date
      2014-10-16 – 2014-10-18
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25130702
  • [Presentation] Role of polycomb group genes in the pathogenesis of myeloid malignancies

    • Author(s)
      Atsushi Iwama
    • Organizer
      EMBO Workshop "Stem Cells and Epigenetics in Cancer”
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2014-10-16 – 2014-10-18
    • Invited
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] Epigenetic regulation of hematopoietic stem cells

    • Author(s)
      Atsushi Iwama
    • Organizer
      International Forum on Stem Cells
    • Place of Presentation
      Tianjin, China
    • Year and Date
      2014-11-01 – 2014-11-03
    • Invited
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] Epigenetic Regulation of Hematopoiesis and disease

    • Author(s)
      Atsushi Iwama
    • Organizer
      Keystone Symposia on “Hematopoiesis”
    • Place of Presentation
      Colorado, U.S.A.
    • Year and Date
      2015-02-22 – 2015-02-27
    • Invited
    • Data Source
      KAKENHI-PLANNED-26115002
  • [Presentation] Epigenetic Regulation of Hematopoiesis and disease

    • Author(s)
      Atsushi Iwama
    • Organizer
      Keystone Symposia on "Hematopoiesis"
    • Place of Presentation
      Colorado, U.S.A.
    • Year and Date
      2015-02-22 – 2015-02-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-24249054
  • 1.  NAKAUCHI Hiromitsu (40175485)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 1 results
  • 2.  CHIBA Tetsuhiro (00381583)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 19 results
  • 3.  SUDA Toshio (60118453)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  SASHIDA Goro (70349447)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 9 results
  • 5.  MIYAGI Satoru (20400997)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 20 results
  • 6.  OHSHIMA Motohiko (70506287)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 15 results
  • 7.  YAMAGUCHI Naoto (00166620)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  SHIBUYA Akira (80216027)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  SHIBUYA Kazuko (00302406)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  EMA Hideo (50344445)
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  • 11.  NAKASEKO Chiaki (30323398)
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  • 12.  中村 幸夫 (60231479)
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  • 13.  YOKOSUKA Osamu (90182691)
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  • 14.  MIMURA Naoya (00422220)
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  • 15.  TAKEUCHI Masahiro (50466702)
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    # of Collaborated Products: 2 results
  • 16.  OHWADA Chikako (80436352)
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  • 17.  Nitta Eriko (80401123)
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  • 18.  真田 昌 (20529044)
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  • 19.  田久保 圭誉 (50502788)
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  • 20.  波江野 洋 (70706754)
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  • 21.  Nishimura Emi
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  • 22.  Sato Toshiro
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  • 23.  Minamino Toru
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  • 24.  Nabeshima Yoichi
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  • 25.  KAWAMOTO Hiroshi (00343228)
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    # of Collaborated Products: 2 results
  • 26.  TANIUCHI Ichiro (20284573)
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  • 27.  BUJO Hideaki (80291300)
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    # of Collaborated Products: 2 results
  • 28.  TAKAKURA Nobuyuki (80291954)
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  • 29.  YAMAGUCHI Yuji (00220286)
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    # of Collaborated Products: 0 results
  • 30.  KOMATSU Norio (50186798)
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  • 31.  NAKAJIMA Yaeko (50749497)
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  • 32.  YOKOTE Koutaro (20312944)
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  • 33.  Iseki Tohru (10232365)
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  • 34.  西宗 義武 (80029793)
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  • 35.  神野 茂樹 (10251224)
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  • 36.  三浦 恭定 (60048965)
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  • 37.  羽地 達次 (50156379)
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  • 38.  松居 靖久 (40241575)
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  • 39.  江藤 浩之 (50286986)
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  • 40.  吉田 行貴 (90436402)
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  • 41.  石川 冬木 (30184493)
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  • 42.  小野寺 雅史 (10334062)
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  • 43.  北村 俊雄 (20282527)
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  • 44.  山崎 聡 (50625580)
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  • 45.  水野 直彬 (30815642)
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  • 46.  OGURO Hideyuki
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  • 47.  MOCHIZUKI Makiko
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  • 48.  Hara Eiji
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    # of Collaborated Products: 1 results
  • 49.  YAMASHITA Masayuki
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    # of Collaborated Products: 0 results
  • 50.  Ho Anthony
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  • 51.  HARADA Yuka
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  • 52.  UEDA Takeshi
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  • 53.  TAKIGUCHI Yuuichi
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  • 54.  TADA Yuji
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  • 55.  KUBUKI Yohko
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    # of Collaborated Products: 1 results
  • 56.  ITO Ryoji
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  • 57.  原田 浩徳
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  • 58.  稲葉 俊哉
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  • 59.  松井 啓隆
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  • 60.  下田 和哉
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  • 61.  北中 明
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    # of Collaborated Products: 2 results
  • 62.  金井 昭教
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  • 63.  小出 周平
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  • 64.  白髭 克彦
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  • 65.  SHARIF JAFAR
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  • 66.  増田 喬子
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  • 67.  三澤 園子
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    # of Collaborated Products: 1 results
  • 68.  小川 誠司
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    # of Collaborated Products: 1 results
  • 69.  篠原 隆司
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    # of Collaborated Products: 1 results
  • 70.  長尾 俊孝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 71.  増子 正義
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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